EP4377407A1 - Adhésif thermofusible détectable aux rayons x - Google Patents
Adhésif thermofusible détectable aux rayons xInfo
- Publication number
- EP4377407A1 EP4377407A1 EP22830611.4A EP22830611A EP4377407A1 EP 4377407 A1 EP4377407 A1 EP 4377407A1 EP 22830611 A EP22830611 A EP 22830611A EP 4377407 A1 EP4377407 A1 EP 4377407A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- hot melt
- melt adhesive
- adhesive according
- previous
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004831 Hot glue Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 25
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 14
- 229920005989 resin Polymers 0.000 claims abstract description 14
- 239000011347 resin Substances 0.000 claims abstract description 14
- 239000002872 contrast media Substances 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 11
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 17
- 239000004014 plasticizer Substances 0.000 claims description 14
- 239000013032 Hydrocarbon resin Substances 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 229920006270 hydrocarbon resin Polymers 0.000 claims description 6
- 229920000098 polyolefin Polymers 0.000 claims description 6
- 239000002530 phenolic antioxidant Substances 0.000 claims description 5
- HECLRDQVFMWTQS-RGOKHQFPSA-N 1755-01-7 Chemical compound C1[C@H]2[C@@H]3CC=C[C@@H]3[C@@H]1C=C2 HECLRDQVFMWTQS-RGOKHQFPSA-N 0.000 claims description 4
- ODJQKYXPKWQWNK-UHFFFAOYSA-N 3,3'-Thiobispropanoic acid Chemical compound OC(=O)CCSCCC(O)=O ODJQKYXPKWQWNK-UHFFFAOYSA-N 0.000 claims description 4
- 239000003490 Thiodipropionic acid Substances 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 235000019303 thiodipropionic acid Nutrition 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 3
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 claims description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 150000001336 alkenes Chemical group 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 claims description 2
- 229920001038 ethylene copolymer Polymers 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 2
- 239000010690 paraffinic oil Substances 0.000 claims description 2
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 claims description 2
- 229920001083 polybutene Polymers 0.000 claims description 2
- 229920005638 polyethylene monopolymer Polymers 0.000 claims description 2
- 229920005629 polypropylene homopolymer Polymers 0.000 claims description 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 2
- 150000007970 thio esters Chemical class 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 abstract description 12
- 238000000034 method Methods 0.000 description 14
- 239000000853 adhesive Substances 0.000 description 11
- 230000001070 adhesive effect Effects 0.000 description 11
- 239000000758 substrate Substances 0.000 description 10
- 229910052500 inorganic mineral Inorganic materials 0.000 description 8
- 239000011707 mineral Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000012467 final product Substances 0.000 description 5
- 229910052601 baryte Inorganic materials 0.000 description 4
- 239000010428 baryte Substances 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000008240 homogeneous mixture Substances 0.000 description 3
- 238000005191 phase separation Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000012943 hotmelt Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 229920006271 aliphatic hydrocarbon resin Polymers 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 229920006272 aromatic hydrocarbon resin Polymers 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000013527 degreasing agent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000012764 mineral filler Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J9/00—Adhesives characterised by their physical nature or the effects produced, e.g. glue sticks
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/04—Non-macromolecular additives inorganic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J1/00—Adhesives based on inorganic constituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/36—Surgical swabs, e.g. for absorbency or packing body cavities during surgery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
- C08K2003/3045—Sulfates
Definitions
- the present invention refers to a hot melt adhesive composition, more specifically, to a hot melt adhesive composition for disposable medical articles, specifically, to an X-rays detectable hot melt adhesive composition that allows the identification of non-woven material left inside the patient body during surgical procedures, therefore, avoiding additional surgery to remove it.
- the present invention refers to a hot melt adhesive composition.
- Hot melt adhesives are applied in a molten state, thus, at high temperatures, over a material surface and harden during the cooling process in which they bond, at least, two materials together. These adhesives are supplied in the solid state and are then melted and applied while fluid. Depending on its properties, the application temperatures can range from 100 °C to 200 °C.
- Hot melt adhesives are advantageous due to their solvent free formulation, fast setting since it occurs during the cooling process, can be repeatedly melted, and applied, extruded in several formats, and applied by different systems. These benefits combined with increased concern with energetic and environmental resources leverage the use of hot melt adhesives by several industrial sectors on a global scale. Besides their ability to correspond complex industrial requirements, hot melt adhesives can be formulated to possess high performance with a low cost. Due to their security and non-toxicity, hot melt adhesives are suitable for, but not exclusively, hygiene and the medical industry.
- a typical hot melt adhesive composition includes a polymeric component, a resin component, and a plasticizer component. Moreover, it can include wax, antioxidant, and mineral fillers, depending on the desired properties. Apart from the technical requirements, the component selection is dependent on the substrate that will be applied on. It is fundamental for the hot melt adhesives used in the medical industry to possess a high adhesion capacity with the different materials that are used in this sector, also referred to as substrates. Depending on the substrate, the chemical base of the hot melt adhesives that are used in the medical industry can be divided into polyolefins, thermoplastic elastomers, acrylates, and polyurethanes.
- the hot melt adhesive Due to the advanced production processes of the medical industry, including automatic processes and several nozzles, it is fundamental for the hot melt adhesive to be versatile in the operational window and to be able to adapt to the fast production speed. Last, the hot melt adhesive must resist the sterilization process to which the final product is submitted to.
- the surgical environment is largely composed of non-woven disposable articles, such as the protective garment, sponges, gauzes, and compresses. Furthermore, in a surgical environment, the surrounding area of the incision is in contact with non-woven material and these products must assure hygienic and sanitary security.
- the blood flow from the patient is inevitable and the incision area is often considered an area of high blood flow.
- disposable nonwoven materials are used to absorb the blood and clean the bleeding area.
- the surgical material that is used during a procedure is controlled to identify situations in where these are forgotten on the body of the patient.
- this control does not identify any missing material, the patient might present considerable discomfort and the possibility of forgotten surgical material inside its body needs to be discarded. For most of the cases, this can only be done by submitting the patient to another surgical procedure, that may or not be justifiable, and additional possible complications and discomfort.
- the present invention relates to a hot melt adhesive for the medical industry, specifically for disposable non-woven articles used in surgical procedures, that has in its composition minerals that are X-rays detectable, thus, making the hot melt adhesive composition X-rays detectable.
- This hot melt adhesive composition is incorporated on the disposable non-woven medical articles that might be in direct contact with the patient body.
- the hot melt ad hesive composition must present a good processability, so it is easily used on the production process of the disposable non-woven medical articles, and should not affect their absorption capacity, flexibility, and resistance to the sterilization process.
- Document CA2487674A1 describes an invention for the surgical field that comprehends a sewed woven sheet with X-rays detectable material (60% barite).
- Document CN101244287A refers to a disposable non-woven article for medical bandages, such as gauze and degreaser non-woven, containing an X-rays detectable material, composed from 40% to 70% barite. This X-rays detectable material is applied directly on the surface of the non-woven disposable articles.
- Document W02011/014907A1 refers to a surgical article with different non-woven layers with an X-rays detectable material that is hydraulically entangled in the non-woven material.
- Document WO2015/035282A1 refers to a polyurethane thermoplastic component combined with barite nanoparticles for the healthcare industry, namely hygiene disposable articles, such as catheters or others containing polyurethanes in its composition and associated with diagnostic means or therapeutic procedures, allowing the radiopacity of these articles.
- Document US2004127614A1 describes a polyolefin composition for several uses, namely hot melt adhesives. Although the polymeric chemical base that is used is the same as the present invention, compositions with antioxidants, resins or contrasting components are not referred in this document, being only mentioned as optional components. Additionally, there is no mention of using this invention for detectable X-rays articles, being the barium sulphate used as a filler and not for its X-rays detectable properties.
- Document CN112266756A describes a hot melt adhesive that comprises an X-rays detectable material to allow the radiographic inspection in industrial assembly lines, in order to improve the quality control in which this adhesive is used.
- Document CN 103517692A refers an X-rays detectable adhesive bandage and a method of manufacturing an X-rays detectable adhesive bandage, wherein said X-rays detectable adhesive bandage has a high sensitivity to detection by an X-rays detection device as well as a high sensitivity to detection by a metal detector.
- barite/barium sulphate is widely used for being X-rays detectable.
- the present invention relates to a hot melt adhesive for the medical industry, specifically disposable non-woven articles to be used in surgical procedures.
- the hot melt adhesive composition comprises X-rays detectable minerals that are compatible and stable with the remaining components.
- This hot melt adhesive composition is suitable for any disposable nonwoven article that might be or not be in direct contact with the interior of the patient body.
- the hot melt adhesive is biocompatible, anti-irritating and no allergic. It is fundamental that the hot melt adhesive composition behaves as an inert when in contact with the patient body, to assure its comfort, and to comply with the legal requirements of the medical industry.
- This hot melt adhesive must possess a high adhesion to the substrates and during the medical procedure must not detach from the substrates, must resist direct contact with body fluids and the handling pressure.
- the hot melt adhesive composition should not have residual tackiness nor leave residues on the surfaces that it contacts.
- the present invention should guarantee that the properties of the disposable non-woven articles, such as absorption capacity, flexibility, and resistance to the sterilization process, are not affected.
- the hot melt adhesive should have a short open and setting time in order to be easily applied on fast industrial lines.
- the implementation of the present invention makes the disposable non-woven articles for medical procedures to be detectable by X-rays and, also, to maintain its original characteristics.
- the hot melt adhesive composition of the present invention is applied on the disposable non-woven articles and develops a strong adhesive bond that assures the quality of the final product and the patient security.
- the object of the present invention is a hot melt adhesive that is detectable by X-rays and is intended for application, namely, but not exclusively, in the medical industry, more specifically, in non-woven materials used in a surgical environment.
- Another object of the present invention is a hot melt adhesive that incorporates in its composition minerals that are detectable by X-rays in an effective and stable way for long periods of time, when subjected to high temperatures.
- Yet another object of the present invention is an X-rays detectable hot melt adhesive, in which properties such as viscosity, softening point, open time and setting time can be controlled by varying the composition of each element of the composition.
- contrast agent is meant one or a mixture of minerals that are radiopaque in X-rays.
- substrate is meant the material or surface of the material to which the hot melt adhesive is applied and/or directly contacts.
- substrates are polyethylene film and polypropylene non-woven fabric.
- open time is meant the maximum time period, after the hot melt adhesive is applied to the first substrate, in which it is possible to effectively bond a second substrate.
- setting time is meant the minimum time interval in which pressure is required for two substrates to bond effectively.
- the setting time is associated with the speed with which the adhesive recovers its cohesive forces.
- base polymer is meant the polymeric materials that contribute to the fundamental characteristics of the composition and form the foundation of the composition. Thus, the remaining components of the composition have the function of altering or improving properties of the polymeric base.
- the hot melt adhesive comprises:
- a polymeric component comprising of at least one polyolefin polymer, which due to its rheological properties is capable of forming a homogeneous mixture with the remaining components of an adhesive, controlling characteristics such as viscosity;
- contrast agent comprising of a mixture of minerals with defined particle size and compatible with the rest of the composition
- an antioxidant component comprising at least one phenolic antioxidant; and optionally:
- plasticizer component comprising at least one plasticizer capable of forming a homogeneous mixture with the contrast agent and the polymeric component, in cases where the polymeric component alone is not capable of doing so.
- the key component of the hot melt adhesive composition is the polymeric component, being responsible for the rheological behaviour of the final product.
- Suitable polymers for the adhesive of the present invention are selected, namely, but not exclusively, from: olefin block copolymers, isostatic propylene and ethylene copolymers, coupled amorphous polyolefins of butene and/or propylene, ethylene and octene copolymers, metallocene-catalyzed polypropylene or polyethylene homopolymer.
- the polymeric component content should be up to 80% by weight of the hot melt adhesive, preferably between 10% and 70%, more preferably between 30% and 65%, even more precisely between 40% and 60%, more concretely between 50% and 55%.
- the main purpose of the resin component is to ensure effective adhesion to the materials used.
- the hot melt adhesive of the present invention is intended to be anti-irritant and anti-allergic, it must consist of a hydrocarbon resin, selected, in particular, but not exclusively, from among : C5 aliphatic, C9 aromatic, C5 aliphatic - C9 aromatic and dicyclopentadiene (DCPD), more preferably C5 and C9 resins and even more preferably hydrogenated C9 aromatic resins.
- a hydrocarbon resin selected, in particular, but not exclusively, from among : C5 aliphatic, C9 aromatic, C5 aliphatic - C9 aromatic and dicyclopentadiene (DCPD), more preferably C5 and C9 resins and even more preferably hydrogenated C9 aromatic resins.
- DCPD dicyclopentadiene
- the hydrocarbon resin content should be up to 40% by weight of the hot melt adhesive, preferably between 1% and 30%, more preferably between 2% and 20%, even more preferably between 3% and 15%, more concretely between 6% and 10%.
- plasticizer component simultaneously allows the melting of the polymer and the adjustment of the viscosity and softening point of the hot melt adhesives to values considered adequate, so that it can be easily applied in industrial lines of disposable articles.
- the hot melt adhesive of this invention presents a plasticizer component as an option, not being essential for its composition, and comprising at least one liquid plasticizer at room temperature, selected, in particular, but not exclusively, from saturated hydrocarbons, polybutenes, mineral oils, hydrotreated naphthenic or paraffinic oils, preferably highly hydrotreated naphthenic oils.
- the contrast agent comprises a barium sulfate compound precipitated with, namely, but not exclusively, 98,5% barium sulfate.
- Barium sulfate is an inert mineral, insoluble in water, acid base and organic solvents, free of impurities, and with a particle size between, but not exclusively, 0,001 and 6 pm in mean diameter.
- the contrast agent content should be up to 65% by weight of the hot melt adhesive, preferably between 10% and 60%, more preferably between 25% and 55%, even more precisely between 30% and 50%, more specifically between 35% and 45%, more concretely between 38% and 42%.
- the use of the antioxidant component aims to prevent the degradation of the hot melt adhesive by the action of heat, either during its production, during application or during storage of the final product.
- an antioxidant component comprising at least one primary, secondary or multifunctional antioxidants is particularly useful.
- selected antioxidants are considered suitable, namely, but not exclusively, from: phenolic antioxidants, phosphites, thioesters, dioctadecyl ester of thiodipropionic acid or a mixture of these, the combination of phenolic antioxidants and dioctadecyl ester of thiodipropionic acid being particularly suitable.
- the content of the antioxidant component suitable for the present invention corresponds to up to 15% by weight of the hot melt adhesive, preferably between 0,1% and 10% and more precisely between 0,2% and 2%, even more concretely between 0,2 % and 0,9%.
- the process for producing the hot melt adhesive detectable in X-rays which is intended for application, in particular, but not exclusively, in the medical industry, more specifically, in non-woven materials used in a surgical environment and which includes in its composition a contrast agent, comprises mixing, with constant agitation, the resin component and the antioxidant component at a temperature between 100 °C and 200 °C, more precisely between 120 °C and 180 °C, more specifically between 150 °C and 170 °C, until a paste with a homogeneous appearance is formed. To this paste, the contrast agent is gradually added. Finally, the polymeric component is mixed with this paste, with constant agitation, until it melts completely, and the paste presents a homogeneous, opaque, and fluid appearance.
- thermal stability test which verifies whether phase separation occurs, which, if so, indicates the incompatibility of the formulation.
- Example 1 The embodiment of Example 1 is presented regarding the composition of a hot melt adhesive for the construction of disposable non-woven articles in the medical industry, with technical properties, namely viscosity and softening point considered appropriate. However, this composition does not include minerals, so it is not considered suitable for the present invention and is presented for comparison purposes only.
- Example 2 The embodiment of Example 2 is presented regarding the composition of a hot melt adhesive for the construction of disposable non-woven articles in the medical industry with technical properties, namely viscosity and softening point considered appropriate.
- This embodiment contains a mineral component in its composition.
- this composition contains a polymeric component different from that described in the invention, more specifically, a copolymer of ethylene and butyl acrylate, and a plasticizer component, so it is not considered suitable for the present invention and is presented only for the purposes of comparison.
- This composition due to the different polymeric component and to the presence of a plasticizer component, does not present adequate thermal stability, verifying phase separation after exposure to 180 °C for an extended period.
- Example 3 refers to the optimization of the properties referred in Example 2, which was obtained by replacing the polymeric component of ethylene vinyl acetate copolymer by a polymeric component of polyolefin and, furthermore, removing the plasticizer component. All desirable technical characteristics were maintained: excellent adhesive capacity, flexibility, resistance to sterilization processes, softening point and viscosity that allow easy application in the final product.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne une composition adhésive thermofusible pour articles médicaux jetables, spécifiquement, une composition adhésive thermofusible détectable aux rayons X qui permet d'identifier un matériau non tissé laissé à l'intérieur du corps du patient pendant des interventions chirurgicales, ce qui permet d'éviter une chirurgie supplémentaire pour le retirer. L'adhésif thermofusible comprend un composant polymère, un composant de résine, un composant antioxydant et un agent de contraste détectable aux rayons X.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT117611A PT117611B (pt) | 2021-11-29 | 2021-11-29 | Cola termofusível detetável em raios x |
PCT/IB2022/061493 WO2023119015A1 (fr) | 2021-11-29 | 2022-11-28 | Adhésif thermofusible détectable aux rayons x |
Publications (1)
Publication Number | Publication Date |
---|---|
EP4377407A1 true EP4377407A1 (fr) | 2024-06-05 |
Family
ID=84627341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22830611.4A Pending EP4377407A1 (fr) | 2021-11-29 | 2022-11-28 | Adhésif thermofusible détectable aux rayons x |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP4377407A1 (fr) |
CO (1) | CO2024004102A2 (fr) |
PT (1) | PT117611B (fr) |
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JP4972284B2 (ja) | 2002-10-15 | 2012-07-11 | エクソンモービル・ケミカル・パテンツ・インク | オレフィン重合のための複数触媒系及びそれらから生成されたポリマー |
US20050109347A1 (en) | 2003-11-25 | 2005-05-26 | Falls William H.Jr. | Surgical towel with x-ray detectable material |
CN101244287B (zh) | 2008-01-28 | 2011-06-15 | 稳健实业(深圳)有限公司 | 一种表面有x光显影物的医用敷料的制作方法 |
DE102008045802A1 (de) * | 2008-09-05 | 2010-03-11 | Henkel Ag & Co. Kgaa | Schmelzklebstoff auf Basis von Metallocene-katalysierten Olefin-α-Olefin Copolymeren |
WO2011014907A1 (fr) | 2009-08-03 | 2011-02-10 | Multigate Medical Products Pty Limited | Produit chirurgical |
JP5271388B2 (ja) | 2011-07-04 | 2013-08-21 | ピアック株式会社 | X線検知用絆創膏およびx線検知用絆創膏の製造方法 |
WO2015035282A1 (fr) | 2013-09-06 | 2015-03-12 | Polyone Corporation | Composés thermoplastiques radio-opaques et optiquement translucides |
CN112266756A (zh) | 2020-11-03 | 2021-01-26 | 杭州三联油墨化学有限公司 | 一种用于射线检测的热熔胶 |
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WO2023119015A1 (fr) | 2023-06-29 |
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PT117611B (pt) | 2024-01-12 |
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