EP4333991A1

EP4333991A1 - Oral care agent

Info

Publication number: EP4333991A1
Application number: EP22722686.7A
Authority: EP
Inventors: Erik Schulze Zur Wiesche; Joachim Enax; Frederic Meyer
Original assignee: Dr Kurt Wolff GmbH and Co KG
Current assignee: Dr Kurt Wolff GmbH and Co KG
Priority date: 2021-05-03
Filing date: 2022-04-28
Publication date: 2024-03-13
Also published as: WO2022233361A1; US20240207157A1; CA3217835A1; DE102021111354A1

Abstract

The present invention relates to an oral care agent, in particular toothpaste or mouthwash. In order to produce a biomimetic or bioinspired oral care agent, in particular for preventing caries and gum diseases, and for gentle and simultaneously effective teeth cleaning, which oral care agent avoids the disadvantages of the prior art, according to the invention the oral care agent contains a methylxanthine, selected from the group consisting of caffeine, theobromine and theophylline, and a calcium phosphate compound, preferably in particulate form, selected from the group consisting of monocalcium phosphate monohydrate (MCPM), anhydrous monocalcium phosphate (AMCP), octacalcium phosphate (OCP), amorphous calcium phosphate (ACP), calcium-deficient hydroxyapatite (CDHA), hydroxyapatite (HA or HAP) and tetracalcium phosphate (TTCP), particularly preferably hydroxyapatite. According to the invention, it has surprisingly been found that the addition of methylxanthines, of which preferably caffeine is used, in combination with the other compounds achieves a synergistic effect.

Description

DESCRIPTION

oral care products

The present invention relates to an oral care product, in particular a toothpaste or mouthwash.

Toothpaste, also known as toothpaste, can be used in combination with a toothbrush to mechanically clean teeth and gums, and is a soft or semi-solid composition for oral use. An oral gel is applied in the same way, but has a gel-like composition.

A mouthwash, also known as a mouthwash, is a liquid formulation that can be used, among other things, to prevent tooth decay and other diseases in the oral cavity.

Dental care is becoming more and more important, if only because of the increasingly carbohydrate-rich diet worldwide. In addition to aesthetic aspects, special emphasis is increasingly being placed on preventive care, with the focus here being primarily on reducing or even avoiding plaque, caries and/or halitosis (bad breath) and healthy gums.

The gums are characterized, among other things, by the fact that they cervically surround the teeth. The gums enclose the neck of the tooth, which seals the entry point of the tooth into the jawbone of the oral cavity. The gums serve, among other things, to protect and hold the tooth.

The different parts of a natural tooth are the tooth crown, tooth neck and tooth root, which are made up of several layers. Of these layers, one normally only sees the outer enamel (enamel), which encloses the dentin and other layers. For example, in order to be able to bite or grind food without damaging the teeth, the tooth enamel is very hard. It consists of about 97% by weight of hydroxyapatite (HAP), which has the empirical formula CasCPC MOH). The dentin is also considered to be the hard tooth substance and also consists of about two thirds of hydroxyapatite. In addition to hydroxylapatite, dentin also contains proteins (eg collagen) and water and is therefore softer than tooth enamel.

Dental diseases such as caries can be based on the formation of bacterial microfilms and/or on bacterial inflammation. Although preventable in many cases, caries remains one of the most common chronic diseases in children and adults and there is a great need worldwide for products to prevent and heal caries-affected teeth.

It is documented that saliva has a remineralizing effect due to its oversaturation of Ca ²⁺ and P0 ₄ ³ ions in a bioavailable form. However, the remineralizing effect brought about by the saliva is not only slow, but also apparently insufficient to protect people from tooth decay and/or to remineralize existing tooth lesions without the addition of mineralization-enhancing additives.

Caries is considered to be a disease dependent on several influences, in particular of tooth enamel and dentin, with the participation of microorganisms. In a first step, a precipitate, also called pellicle, can form on the tooth surface, including saliva protein. The rougher the tooth surface, the easier it is for the deposit to form or adhere to it. After some time, this pellicle forms a film that covers the tooth surface and is a few microns thick. Bacteria can then continue to multiply and spread on this film, whereby this film can be regarded as a biofilm. Furthermore, the bacteria mentioned can produce organic acids, such as gluconic and lactic acid, from the low-molecular carbohydrates frequently found in today's food. Both these organic acids produced by bacteria and the acids supplied through food, such as fruit acids, can cause erosion of the tooth structure. Here, among other things, calcium phosphates are dissolved from the tooth enamel. Will this process not be stopped or preferred even vice versa, after a while, the enamel and possibly also the dentin can demineralize. A defect in the hard tooth substance that arises in this way is referred to as a carious lesion, with carious lesions on the dentin layer being recognizable, for example, by a yellow to brown discoloration of the corresponding part of the tooth. So while carious lesions on the tooth enamel can often be reduced or eliminated simply by renewed mineralization of the tooth enamel, in the case of carious lesions that affect other layers in addition to the tooth enamel, the damaged part of the tooth is usually removed and the resulting hole (caries lesion ) closed with a filling material. In summary, it can be said that caries formation can be favored by the interaction of the following factors:

- special bacteria sticking to the pellicle poor tooth quality or mineral quality of the tooth plaque

- food containing low molecular weight carbohydrates

- Time.

One possibility for caries prophylaxis could accordingly lie in the supply of calcium phosphate compounds, in particular hydroxylapatite. In addition, there are different approaches, all aimed at preventing tooth decay, in order to avoid the above treatments. Caries prophylaxis with fluoride-containing dental care products can be regarded as the current standard. J. M. ten Cate: "Contemporary perspective on the use of fluoride products in caries prevention", British Dental Journal, February 23, 2013, vol. 214, no. 4, pp. 161-167, describes the use and mode of action in a review article of fluoridated dental care products such as toothpaste and mouthwash. It is specifically noted that with these fluoridated dental care products, caries reduction is achieved through their regular use. As a model, it is assumed that fluoride accelerates the natural mineralization from the saliva.

Various fluoride compounds, such as sodium fluoride, stannous fluoride, amine fluorides and sodium monofluorophosphate). JM ten Cate: "The Need for Antibacterial Approaches to Improve Caries Control", Adv Dent Res 21 :8-12, August 2009, pp. 8-12, deals with the fact that the provision of fluoride alone may not be enough to ensure adequate caries prevention because, as mentioned above, bacteria also play a crucial role in the formation of caries. However, the fluoride ion itself does not show a pronounced antimicrobial effect against bacteria that can cause caries. For this reason, compositions for caries prevention are considered, which in addition to fluoride also contain should contain one or more antimicrobial substance(s), such as chlorhexidine (CFIX), whose antimicrobial effect in the oral cavity has been investigated in many studies.

However, the use of fluorides in dental care products is also discussed controversially, as negative side effects are feared. One of these is called dental fluorosis, which is caused by excessive fluoride intake during tooth formation. Acute toxic effects include nausea, vomiting and diarrhea. Other examples are bone fluorosis, which manifests itself in the thickening of the outer bone layer and the associated loss of elasticity and resilience of the bones, and enamel fluorosis, which can be recognized by the appearance of whitish enamel spots on the tooth surface. In addition, it is reported that swallowing high-dose dental care products can trigger acute fluoride poisoning, especially in children, which can sometimes even be fatal (Bashash, M. et al. Prenatal fluoride exposure and cognitive outcomes in children at 4 and 6-12 years of age in Mexico. Environ. Health Perspect. 125, 097017 (2017)). Furthermore, it is reported that the WFIO is not able to establish a value for a daily fluoride requirement because fluoride is not an essential trace element and thus there are no diagnostic parameters and no evidence for the existence of clinical symptoms of "fluoride deficiency".

The use of an antimicrobial substance such as chlorhexidine in dental care, especially in caries prophylaxis, is also controversial. It was reported that a relevant effect for caries prophylaxis is not always reproducible and only occurs in some of the cases examined. Furthermore, the antimicrobial effect of chlorhexidine is not limited to the bacteria in the mouth that contribute to caries formation, but also includes beneficial bacteria. In addition, long-term treatment with products containing chlorhexidine leads to undesirable side effects such as tooth discoloration and taste disorders.

Biomimetic tooth and mouthwash solutions with artificial tooth enamel can contain zinc carbonate hydroxyapatite, for example. This zinc carbonate hydroxyapatite is also known commercially as Microrepair. Zinc-carbonate-hydroxyapatite-based products can reduce the initial bacterial colonization on the enamel surface without having antimicrobial properties that can disturb the ecological balance of the oral cavity. In addition, these products are intended to serve, among other things, for remineralization and the repair of microfine defects in tooth enamel and the formation of a protective layer.

Due to the above limitations in both the salivary homeostatic mechanism and the fluoride addition-based approaches to caries prevention and mineralization, there is a need for alternative strategies that are at least equivalent to the efficiency of fluoride addition in mineralization without the corresponding undesirables show side effects.

There are also biometric dental care products based on the use of hydroxyapatite. For example, DE 102002001 823 A1, WO 2018/024649 A1, DE 102017009626 A1 and DE 102018 102365 describe oral care compositions which contain synthetic hydroxyapatite, where hydroxyapatite, as indicated above, is a bioactive and compatible material with a similar chemical composition to the apatite of human tooth enamel.

Methylxanthines, in particular caffeine, theobromine and theophylline, are also used in many areas of cosmetics and cosmetics due to their stimulating effect used personal hygiene.

DE 29806937 U1 describes a toothpaste to which one or more stimulating substances are added, which can be caffeine or nicotine, for example.

DE 201 19966 U1 also describes a toothpaste enriched with invigorating substances, with caffeine and/or theine or other stimulating substances being contained in the toothpaste formulation.

A toothpaste containing caffeine is also known from JP 2010/275261 A1.

It is also known from the publication "Neurophysiological effect of flavor and caffeine added to toothpaste", Sangyo Eiseigaku Zasshi, Vol fortify caffeine.

Compositions for oral hygiene products, in particular toothpastes, which contain caffeine and lysine-containing bitter blockers are known from WO 2021/013283 A1. Since oral hygiene products are usually not swallowed but spat out, the caffeine must be present in a sufficiently high concentration for it to be effective. The bitter blockers serve to achieve a pleasant taste experience even with these very high caffeine concentrations.

Finally, Johnson & Johnson also offers a mouthwash containing caffeine under the name "LISTERINE GREEN TEA".

The dwell time of toothpaste or mouthwash/mouthwash in the oral cavity is limited to approx. 30 seconds to a maximum of 3 minutes, so that only a little caffeine can interact with the gums during the period of dental care. These are then usually spat out and usually rinsed out with water. As a result, the effective concentration of caffeine in the oral cavity decreases very quickly. Such oral hygiene products serve to care, moisturize and kill bacteria, but have no long-term positive effect on the cells of the gums.

Caffeine has a positive effect on the cardiovascular system. In the study Spyridopoulos et al. (2008), Arterioscler Thromb Vase Biol, 28, 1967-1974, it was shown that after drinking four cups of coffee, a caffeine concentration of 20-50 micromoles/liter in blood serum is reached in humans, which corresponds to a total amount of 15-35 milligrams is equivalent to.

Caffeine in these physiological concentrations led to functional improvements in the cells of the innermost layer of the blood vessel wall, the endothelial cells, and their precursors. Interestingly, these phenomena were dependent on intact mitochondria, implying that these cell organelles play a central role in caffeine-induced enhancement of endothelial cell function.

Mitochondria provide the energy the body needs in the form of the molecule adenosine triphosphate (ATP). The substrates required for this, so-called reduction equivalents (NADFTFT and FADFI2), originate e.g. from the citric acid cycle and fatty acid oxidation, processes that also take place in the mitochondria.

The reduction equivalents are channeled into the respiratory chain where they are used to reduce oxygen to water. Oxygen radicals are constantly being produced as a by-product of the respiratory chain, which can damage macromolecules such as proteins, lipids and the DNA present in the mitochondria and ultimately damage the functioning of the mitochondria.

The production of oxygen radicals increases with advancing age and is also increased in cardiovascular diseases and type 2 diabetes mellitus, which explains the loss of function of the mitochondria both in old age and in the diseases mentioned.

Recent studies provide clues to the molecular mechanism of caffeine on mitochondria. According to recent studies, caffeine has a strengthening effect on the import of p27 (CDKNIB, “Cyclin Dependent Kinase Inhibitor IB”) into mitochondria. This was accompanied by an improvement in the functioning of various heart cell types. In this way, heart muscle cells were protected from cell death, such as that which occurs during a heart attack. Furthermore, connective tissue cells of the heart, cardiac fibroblasts, were better able to differentiate into myofibroblasts. Myofibroblasts compensate for dead heart muscle cells by forming scar tissue. Furthermore, endothelial cells showed an increased ability to migrate, which is essential for the healing of vascular damage. In mice, the functionality of the mitochondria from old animals could be brought back to the level of younger animals by administering caffeine as a function of p27. Ultimately, the administration of caffeine in the drinking water of mice, which had previously been brought to the physiological level of a type 2 diabetic by means of special diets, reduced the damage after an experimental heart attack. These studies support the findings from epidemiological studies, according to which moderate caffeine consumption has a positive effect on the cardiovascular system.

In addition, it has long been known that caffeine increases the analgesic potency of acetylsalicylic acid or paracetamol.

Other uses of caffeine are, in addition to increasing alertness and eliminating signs of fatigue, circulatory and respiratory stimulation, prevention of bronchopulmonary dysplasia and other effects on skin and hair.

Caffeine-containing oral care products are also known, these oral care products being based on the above effects of caffeine.

DE 201 19966 U1 also describes one with invigorating substances fortified toothpaste containing caffeine and/or theine or other stimulating substances in the paste formulation.

A toothpaste containing caffeine is also known from JP 2010/275261 A1.

It is also known from the publication "Neurphysiological effect of flavor and caffeine added to toothpaste", Sangyo Eiseigaku Zasshi, Vol fortify caffeine.

Compositions for oral hygiene products, in particular toothpastes, which contain caffeine and lysine-containing bitter blockers are known from WO 2021/013283 A1. Since oral hygiene products are usually not swallowed but spat out and rinsed with water, the caffeine must be present in a sufficiently high concentration for it to be effective. The bitter blockers serve to achieve a pleasant taste experience even with high caffeine concentrations.

Johnson & Johnson offers a mouthwash containing green tea extract under the name "LISTERINE GREEN TEA".

The manufacturer Splat Global also offers a toothpaste under the name "Energy Mint Whitening Coffee Out Toothpaste", which contains, among other things, caffeine as well as tricalcium phosphate and calcium pyrophosphate as a cleaning agent.

The manufacturer Carbon & Clay offers a toothpaste under the name "Magical Mint CBD Hemp Oil + Silver Toothpaste", which contains theobromine, among other things.

The manufacturer dr. Kaschny Healthcare offers a mouthwash called "Mouthwash with Caffeine" that contains caffeine, among other things.

From the JP 2010-275261 A is a toothpaste, the xanthine derivatives selected from the group consisting of caffeine, theophylline, theobromine and their salts, water, glycerin and a binder. This toothpaste can also contain cleaning particles.

However, there continues to be a need for an oral care composition for the treatment or prevention of various dental disorders.

Toothpaste according to the prior art contains abrasives, also referred to as cleaning bodies or abrasives, which remove plaque and harmful bacteria from the tooth surface during the tooth cleaning process, usually together with the toothbrush, and can also provide a brightening (whitening effect). Toothpastes contain abrasives or abrasives in an amount of up to 15% by weight or more, based on the total weight of the toothpaste. Examples of abrasives are whitewash, marble powder and/or silicate compounds such as silica. Polysilicic acids (hydrated silica) and calcium carbonate are most commonly used worldwide. The disadvantage is that with the exception of calcium phosphate compounds (e.g. hydroxyapatite) - all cleaning body types are foreign to the body and do not correspond to the natural tooth mineral (hydroxyapatite). For example, in the case of cleaning bodies with a high relative hardness, the hard tooth substance can be irreparably damaged. If the cleaning body is not sufficiently hard, the cleaning performance of the overall toothpaste formulation may be too low to effectively remove plaque during tooth brushing (increased risk of caries and periodontitis).

Furthermore, when using the product, the ecological balance in the oral area should not be significantly disturbed and/or tooth discoloration or taste disturbances should not be at risk.

The object of the invention is to create an oral care product, in particular a toothpaste or a mouthwash, with one or more biomimetic or bioinspired active ingredient(s), in particular for the prevention of caries, which avoids the disadvantages of the prior art described above. In particular, an oral care product, in particular a toothpaste or a mouthwash, is to be provided which mineralizes existing, smaller caries lesions and/or repairs microfine defects in the tooth enamel. Furthermore, a protective layer should be applied to the tooth and/or open dentine tubules should be closed. To this end, the above-mentioned effects should be achieved, with the aim being to avoid the disadvantages that can be associated with the use of fluoride. Furthermore, the adhesion of bacteria on the tooth enamel should advantageously be reduced without significantly disturbing the ecological balance in the oral cavity and/or risking tooth discoloration or taste disturbance. The oral care product should also not have any irritating effect on the mucous membranes.

These objects are achieved with an oral care product according to the preamble in that the oral care product contains a methylxanthine selected from the group consisting of caffeine, theobromine and theophylline and a calcium phosphate compound, preferably in particulate form, selected from the group consisting of monocalcium phosphate monohydrate (MCPM), Monocalcium phosphate anhydrate (MCPA), octacalcium phosphate (OCP), amorphous calcium phosphate (ACP), calcium-deficient hydroxyapatite (CDHA), hydroxyapatite (HA or HAP) and tetracalcium phosphate (TTCP), particularly preferably hydroxyapatite.

It has surprisingly been found within the scope of the invention that methylxanthines bring about a synergistic effect in combination with the calcium phosphate compounds mentioned, which have a remineralizing effect and are not primarily intended for use as cleaning agents. The addition of methylxanthines, of which caffeine is preferred, significantly increases the binding of the calcium phosphate compounds mentioned to the teeth and/or the gums. Conversely, the calcium phosphate compounds mentioned also bind methylxanthines to the teeth and/or the gums, as a result of which a depot effect is achieved. In the present case, the methylxanthine is not because of its stimulating effect, but because of this synergistic effect, the oral care product and its gum regenerating effect added.

The calcium phosphate compound can exist in different crystal forms, also in the form of mixtures of these crystal forms, with more round crystal forms being preferred over more pointed crystal forms (e.g. needle-shaped crystals). They can also have different crystal and aggregate sizes, also in mixed form, and have different crystal minities, also in mixed form.

On the other hand, other calcium phosphate compounds that are used as cleaning agents, in particular calcium pyrophosphate, calcium diphosphate and tricalcium phosphate (α-TCP, ß-TCP), have surprisingly been selected in combination with a methylxanthine from the group consisting of caffeine,

Theobromine and theophylline proved to be significantly less effective in remineralization, reduction of biofilm formation and reduction of sensitive teeth and gum regeneration, so that the present oral care product is free of the aforementioned compounds. In an application study with 50 participants, the subjective perception of the use of methylxanthine-containing oral care products with remineralizing calcium phosphate compounds in terms of reducing pain-sensitive teeth and gum regeneration proved to be significantly better than that of methylxanthine-containing oral care products with calcium phosphate compounds that are used as cleaning agents.

Flydroxyapatite (CasCPC MOFI)) is also known as Hydroxyapatite. It is a mineral from the mineral class of phosphates, which crystallizes in a hexagonal crystal system. In addition, hydroxyapatite is a member of the apatite group and forms a complete mixed series with chlorapatite and fluorapatite.

A CasCPC MOFI suitable according to the invention is described, for example, in DE 10 2016 114 189.5. The CasCPC MOFI) used according to the invention is preferably produced synthetically. This means that the CasCPC MOFI) used according to the invention is preferably not produced by burning out the organic Components derived from animal material such as bones.

The calcium phosphate compounds used according to the invention can be present both in pure form and in the form of substituted compounds and as mixtures thereof. A pure form is present according to the invention when the ions contained in the respective calcium phosphate compound are each less than 1%, preferably less than 0.5%, even more preferably less than 0.1% substituted by one or more other ions. For example, in pure flydroxylapatite, the Ca ²⁺ ions are substituted by, for example, Mg ²⁺ or Zn ²⁺ to an extent of less than 1%, preferably less than 0.5%, even more preferably less than 0.1%.

Furthermore, the calcium phosphate compounds preferably contain no doping, such as, for example, a zinc carbonate doping. However, doped calcium phosphate compounds can also be used.

The X _ö o value of the volume-based particle size distribution of the calcium phosphate compounds is 1.0 nm to 100.0 pm, preferably 10 nm to 10.0 pm, more preferably 50 nm to 1 pm, particularly preferably 100 nm to 5500 nm, where the X5o value of the volume-based particle size distribution is measured using laser diffraction.

For this purpose, a sample of the calcium phosphate compounds is first sonicated in an ultrasonic homogenizer with an energy output of 96 W for 9 minutes and then for a further 3 minutes in a device for sample preparation. The subsequent particle size distribution measurement (laser diffraction) is carried out in a particle size determination instrument at a temperature of 25°C ± 0.3°C and the corresponding values are calculated according to the Mie theory. The measuring instruments used are exclusively commercially available devices.

In a preferred embodiment of the invention, the calcium phosphate compound is Cas(P0 ₄ ) ₃ (OH) and has a hexagonal crystal lattice in which the length of the a-axis is 0.930 to 0.950 nm, preferably 0.933 to 0.948 nm, particularly preferably 0.936 to 0.945 nm and the length of the c-axis is 0.680 to 0.700 nm, preferably 0.682 to 0.696 nm, particularly preferably 0.685 to 0.692 nm. The lengths of the a-axis and the c-axis are determined by a Rietveld analysis of the corresponding X-ray powder diffractograms. The X-ray powder diffractograms themselves are obtained by means of a measurement using a conventional powder diffractometer with the routine settings.

In a preferred embodiment of the invention, the at least one calcium phosphate compound is in aggregated form. In this case, aggregation is understood to mean the accumulation of molecules or particles to form a larger association, the aggregate. This assembly or aggregation is brought about and held together by various forces and/or types of bonding, such as ionic bonding, van der Waals forces, intermolecular forces or other types of chemical bonding. The degree of aggregation and also the size of the aggregate can be determined using scanning electron microscopy.

It has proven to be advantageous within the scope of the invention that the oral care product contains at least one compound selected from the group consisting of antibacterial substances, moisturizing or care substances, desensitizing substances and abrasives.

Furthermore, it has surprisingly been found within the scope of the invention that methylxanthines in combination with antibacterial substances, in particular tin salts, chlorhexidine, cetylpyridinium chloride, triclosan, o-cymen-5-ol, enzymes, proteins and citrus extract, have a synergistic effect.

It has also surprisingly been shown within the scope of the invention that methylxanthines in combination with moisturizing or caring substances, in particular hyaluron, hyaluron salts, allantoin, panthenol, natural extracts (eg ectoine) and amino acids (eg arginine) have a synergistic effect. Furthermore, it has surprisingly been found within the scope of the invention that methylxanthines in combination with desensitizing substances, in particular strontium salts, bring about a synergistic effect.

It has also surprisingly been found within the scope of the invention that methylxanthines bring about a synergistic effect in combination with cleaning bodies, in particular calcium carbonate and sodium bicarbonate.

In addition, it has surprisingly been found within the scope of the invention that methylxanthines show a synergistic effect in combination with soft cleaning bodies for plaque removal, in particular calcium carbonate and sodium bicarbonate.

The active ingredients and groups of active ingredients mentioned above can each be combined individually with one or more methylxanthines, or several of the active ingredients or groups of active ingredients mentioned above can be combined with one or more methylxanthines.

Furthermore, it surprisingly turned out within the scope of the invention that a significant activation of the cell metabolism and thus an effective treatment and/or prevention of periodontitis/gingivitis and receding gums is possible with the oral care product according to the invention.

The oral care product according to the invention is intended for daily use with one to two applications per day.

If it is in the form of an oral gel, it does not have to be spat out, but can also be absorbed over a longer period of more than 3 minutes, preferably between 5 minutes and 12 hours, particularly preferably between 10 minutes and 1 hour. Due to the gel-like composition, the adhesion of the methylxanthine directly to the gums or the gum line is supported, so that the methylxanthine is in direct contact with them over a longer period of time, as a result of which a high absorption rate is achieved. Here, the methylxanthine is dosed differently depending on the user group. A daily dose of 0.3 mg methylxanthine/kg body weight (EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies, 2015, Scientific opinion on the safety of caffeine, EFSA Journal 2015; 13 (5); 4102, 120 pp. Doi:10.2903/j.efsa.2015.4102) not to be exceeded, which can be ingested via a single application as well as multiple applications over the course of a day (with 1 to 3 applications per day being preferred).

The oral care product preferably contains methylxanthine in an amount of 0.00001 to 4.0 percent by weight, preferably from 0.0001 to 1.0 percent by weight and particularly preferably from 0.0005 to 0.001, in particular 0.005 percent by weight, based in each case on the total weight of the oral care product .

Anionic, nonionic, cationic and zwitterionic surfactants can be used as surfactants, with nonionic surfactants often being avoided because of their adverse effects on the antibacterial compound; likewise, cationic and zwitterionic surfactants are often avoided as they stain or darken teeth. Accordingly, anionic surfactants are used as the cleansing component in the oral composition, with sodium lauryl sulfate and other higher alkyl sulfates containing from 10 to 18 carbon atoms in the alkyl group being frequently used, although other known sulfated and sulfonated surfactants may be employed in part or in full as such.

The oral care composition preferably contains at least one surfactant selected from the group consisting of taurates, glycinates, sarcosinates and quaternary ammonium compounds, preferably sodium methyl cocoyl taurate, sodium cocoyl glycinate, sodium lauroyl sarcosinate, benzalkonium chloride or cetyl pyridinium chloride.

However, since sodium lauryl sulfate is also irritating to the mucous membranes, the oral care product according to the invention can also be free of sodium lauryl sulfate and instead contain other surfactants that cause less irritation to the mucous membranes than Bring sodium lauryl sulfate, like taurates, preferred

Sodium methyl cocoyl taurate, glycinates, preferably sodium cocoyl glycinate, sarcosinates, preferably sodium lauroyl sarcosinate, or quaternary ammonium compounds, preferably benzalkonium chloride or cetylpyridinium chloride. The specification of the respective surfactants also includes all variants thereof (different alkyl chains, branches in the alkyl chains, counterions, etc.). Surfactants are important for a toothpaste because they help distribute the active ingredients in the oral cavity while brushing your teeth. Surfactants are also important for consumer convenience.

For example, sodium lauryl sulfate-free oral care products may be important for people with sensitive or irritated gums (children, periodontitis patients, people with xerostomia/hyposalivation). Sodium lauryl sulfate and silica are the most potent active ingredients in cosmetic oral care preparations for fighting plaque. In the present invention, the disadvantages of these two active ingredients (sodium lauryl sulfate: irritating to the mucous membranes; silica: potentially damaging to teeth, not remineralizing) could be overcome for the first time; i.e. a gentle but effective cleaning for the mucous membrane and teeth with simultaneous effective remineralizing, antibacterial and anti-caries protective effect.

In particular, it was unexpectedly found that the oral care product according to the invention advantageously mineralizes smaller caries lesions and/or repairs microfine defects in the tooth enamel, especially in patients with dry mouth/lack of saliva. Furthermore, the composition according to the invention can be used to apply a protective layer to the tooth, and it has also been found that the tooth enamel has advantageous solubility and resistance to acids after the composition according to the invention has been used. In addition, antimicrobial substances (such as, for example, chlorhexidine) as auxiliary substances can be dispensed with in the present composition. In this way, excellent caries prophylaxis can be guaranteed without, for example, disturbing/destroying the bacterial balance in the oral cavity and without risking unpleasant side effects. In particular, it was unexpectedly found that the oral care product according to the invention prevents caries and lesions can also be mineralized down to the deeper layers of the tooth, in particular the tooth enamel. Furthermore, the oral care agent according to the invention can be used to apply a protective layer to the tooth and over exposed dentin, and in particular to close open dentinal tubules. Furthermore, it was found that the tooth enamel after the application has a significantly reduced or no longer detectable structural damage. In addition, the use of fluoride can be completely dispensed with with the present oral care product; this oral remedy is free from fluoride. In this way, the above positive aspects can be guaranteed without, for example, disturbing/destroying the bacterial balance in the oral cavity and without risking undesirable side effects, which can occur, for example, when using fluoride-containing oral care products. The subject matter of the present invention is an oral hygiene product for mineralizing teeth, in particular tooth enamel, down to a depth of 200 μm, preferably up to 100 μm (deep mineralization).

The oral care composition according to the invention comprises calcium phosphate compounds in an amount of 0.01 to 80% by weight, preferably 0.1 to 20% by weight, particularly preferably 1 to 10% by weight and in particular 1 to 5% by weight on the total weight of the oral care product. The preferred amount of calcium phosphate compounds is 1 to 5% by weight for mouthwashes and 10 to 20% by weight for toothpastes, based in each case on the total weight.

The oral care composition according to the invention preferably contains at least one calcium compound selected from the group consisting of calcium carbonate, calcium chloride, calcium bromide, calcium nitrate, calcium acetate, calcium gluconate, calcium lactate, calcium tartrate and their hydrates and mixtures thereof, preferably calcium carbonate.

In a preferred embodiment of the invention, the oral hygiene composition contains a stannous salt and/or chlorhexidine and/or triclosan and/or an amino acid and/or an enzyme and/or hyaluronic acid and/or a strontium salt and/or sodium bicarbonate.

The tin salt can be, for example, tin chloride. An example of an amino acid is arginine. Examples of possible enzymes are lactoferrin or lysozyme.

Alternatively, it is also possible that the oral care product is free from tin salts and/or chlorhexidine and/or cetylpyridinium chloride and/or triclosan.

The oral care product according to the invention preferably contains no perlite. Perlite is a abrasive with a high relative hardness and can damage teeth.

The oral care product according to the invention preferably does not contain any aluminum compounds. Aluminum compounds can be potentially toxic.

The oral care product according to the invention preferably contains no diamond particles. Diamond is a abrasive with a high relative hardness and can damage teeth.

The oral care product according to the invention preferably contains no cellulose fibers (microcrystalline cellulose=cleaning particles). Cellulose fibers often lead to an unpleasant feeling in the mouth, so that user compliance is severely limited.

The oral care product according to the invention preferably contains no sodium bicarbonate. Sodium bicarbonate has only a very low cleaning capacity.

The oral care product according to the invention preferably does not contain any glucosides. Glucosides can split off glucose, which favors the unwanted development of caries.

The oral care product according to the invention does not contain any abrasives Polymer particles fmicrobeads” (e.g. polyethylene beads). Such polymer particles can have harmful effects on the environment.

The oral care composition according to the invention preferably does not contain sulfates, such as sodium lauryl sulfate, or sulfonates.

Furthermore, the oral care product according to the invention preferably does not contain any tin salts, such as tin fluoride and tin chloride, since these can lead to discoloration of the teeth.

The oral care product according to the invention preferably also does not contain any peroxides, since these are irritating to the mucous membranes.

Furthermore, the oral care product according to the invention preferably also contains no enzymes and is therefore a vegan product.

The oral care product according to the invention is used for the mineralization of teeth down to a depth of 200 μm, preferably up to 150 μm, in particular up to 100 μm. Such mineralization of teeth down to these depths is referred to as deep mineralization, since in this case not only the tooth surface areas down to a depth of approx. 30 μm, as described in the prior art, but also deeper-lying areas of the tooth are mineralized.

It has been found that the oral care composition of the present invention can be used in the treatment and/or prevention of a variety of dental conditions.

In a preferred embodiment of the invention, the oral care composition according to the invention can be used to treat (dental) diseases/conditions selected from caries, tooth erosion, tooth abrasion, attrition, bruxism, molar incisor hypomineralization (MIH), amelogenesis imperfecta, dentinogenesis imperfecta and fluorosis. The term caries is familiar to those skilled in the art. Caries is generally understood to mean a destructive disease of hard tooth tissue, tooth enamel and dentine.

Tooth erosion is understood to mean damage to the tooth structure by acids, in other words defects in the enamel and/or dentin caused by dental erosion, which, if treated too late, can lead to irreversible damage.

(Tooth) abrasion is understood to mean the loss of tooth structure through friction. Attrition is a subtype of abrasion, namely the loss of tooth structure through reflective touching of the teeth.

Bruxism is unconscious grinding or clenching of the teeth, usually at night but also during the day, with the result that not only the teeth but also the periodontium and chewing muscles can be worn out.

The molar incisive flypomineralization (M IH), which is also known under the name "chalk teeth", is an enamel image disorder, i.e. structural damage to the enamel.

Amelogenesis imperfecta is considered to be a genetic disease in which tooth enamel formation is disrupted. As a result, the teeth have an increased risk of caries formation and are particularly sensitive to temperature.

Dentinogenesis imperfecta is an autosomal dominant inherited malformation/structural disorder of dental dentition, which occurs in approximately 1 in 8000 people and results in severe tooth abrasion.

Tooth (fluorosis) (also: dental fluorosis) is a non-inflammatory disease (“mottled teeth”), which is caused by excessive fluoride intake, particularly during the ontogenetic development of the teeth. It has been found that the above tooth (diseases) can be prevented and/or their progression at least significantly slowed down and/or complete restoration of the tooth substance, in particular the hard tooth substance, can be achieved by the use according to the invention. In particular, it was found that the use according to the invention or after its application shows significantly reduced or no longer detectable structural damage to the tooth enamel.

In a preferred embodiment, the oral care product according to the invention can be used to treat code 3 or code 4 caries, preferably code 3 caries, determined according to the International Caries Detection and Assessment System (ICDAS).

According to the International Caries Detection and Assessment System (ICDAS), caries is divided into different codes (levels), whereby the higher the code, the greater the caries infestation on the tooth and consequently its effects on this tooth.

With a code 0 caries, no signs of caries are visible after drying in the air stream for about 5 seconds.

In the case of code 1 caries, the first visual changes in the enamel surface are visible after the tooth has dried. The changes can be opacity, whitish or brownish discolouration.

In the case of code 2 caries, clear visual changes in the enamel surface are already present on the moist tooth. These changes can be opacity in the sense of a white spot lesion and/or brownish carious discolouration in the fissures/pits and must still be visible on the dried tooth.

In code 3 caries, there is demineralization or loss of the enamel structure without visible changes in the dentin. The opacities and/or brownish or black carious changes extend beyond the border of the fissures/pits and are visible even after the tooth has dried. If necessary, a WHO probe can be carefully passed over the enamel defect to palpate the discontinuity of the enamel surface.

In code 4 caries, there is shadowing in the dentin, with or without enamel collapse. Shadow formation can be greyish, bluish or brownish.

Code 5 caries shows clear cavity formation with visible dentine. The loss of enamel is clearly visible on the dried tooth. If necessary, the WHO probe can be used to palpate the exposed dentine.

With code 6 caries, there is extensive cavitation, with the dentine clearly visible in the width and depth of the tooth. At least half of the enamel surface has been destroyed by caries. The pulp can be affected.

In a preferred embodiment, the oral care product according to the invention can be used both for cosmetic and for medical purposes. This means that it can be used not only for the treatment of the above-mentioned (dental) diseases, but also for cosmetic purposes such as beautifying the appearance of the teeth.

In a preferred embodiment, the oral care product according to the invention is used in people of all ages, including children, in the case of children preferably in children aged 6 months to 14 years, in particular in children aged 10 months to 12 years.

In a preferred embodiment, the CasCPC MOH) contained in the oral care product according to the invention is the only apatite component of the oral care product. In a preferred embodiment, the oral care composition according to the invention comprises 0.01 to 80% by weight, preferably 0.2 to 40% by weight, more preferably 0.5 to 30% by weight, in particular 1.0 to 20% by weight, of calcium phosphate compounds in one In a preferred embodiment of the invention, the oral care product according to the invention can contain 1% by weight, 2% by weight, 3% by weight, 4% by weight, 5% by weight, 6% by weight, 7% by weight, 8% by weight, 9% by weight %, 10%, 11%, 12%, 13%, 14%, 15%, 20% or 25% by weight of calcium phosphate compounds.

In a preferred embodiment, the oral care product according to the invention comprises one or more calcium salts which have a solubility of at least 10 mg/l H2O at 20°C. The solubility is determined according to methods known to those skilled in the art or can be found in the relevant specialist literature.

In a preferred embodiment, the oral care product according to the invention can contain one or more pharmaceutical or cosmetic ingredients. These pharmaceutical or cosmetic ingredients are described, for example, in Toothpastes, Monographs in Oral Science, Vol. 23, Ist edition, 2013.

Preferably, the one or more pharmaceutical or cosmetic ingredients include xylitol, antimicrobials, pH regulators, abrasives, flavorings, and humectants, particularly xylitol, pH regulators, abrasives, and flavorings.

Xylitol can minimize the number of caries bacteria and inhibit their growth. Xylitol can also stimulate salivation. The increased amount of saliva produces an increased amount of phosphate. This phosphate can react with the calcium (ions) of the oral care product according to the invention to form hydroxyapatite. The oral care product according to the invention can contain xylitol in an amount of 0.5 to 15% by weight, preferably 1 to 10% by weight, in particular about 7.0% by weight, based on the total weight of the oral care product. In addition to xylitol, the oral care product according to the invention can contain other sugar alcohols such as sorbitol.

Antimicrobial substances are substances that can kill microorganisms, such as bacteria, or greatly reduce their reproduction. In addition to antimicrobial substances with a non-specific defense against bacteria and fungi, there are also those that only work against targeted bacteria, for example. The use of antimicrobial substances can also combat bad breath, for example. Antimicrobial substances can preferably be contained in the oral care product according to the invention in an amount of 0.01 to 2.0% by weight, preferably 0.05 to 1.0% by weight. Examples of the antimicrobial substances used in oral care are zinc compounds such as zinc chloride and zinc citrate, as well as cetylpyridinium chloride, essential oils and surfactants.

In a particularly preferred embodiment, the oral care composition according to the invention is free from fluorides and/or tin salts and/or chlorhexidine and/or cetylpyridinium chloride and/or triclosan. pH regulators are substances that can set a specific pH range, preferably a range from pH 5.5 to 8.0. If the composition was too acidic, there would be a risk of demineralization of the tooth structure (erosion).

Examples of pH regulators are acetic acid, acetates, lactic acid, lactates, malic acid, malates, fumaric acid, citric acid, citrates, tartaric acid, tartrates, orthophosphates, di-, tri- and polyphosphates, hydrochloric acid, chlorides, sulfuric acid, sulfates, hydroxides, oxides, Adipic acid, adipates, gluconic acid, gluconates, phosphoric acid, calcium carbonate or a hydrate thereof. A preferred example of a pH regulator that can be added when a lower pH is desired is phosphoric acid (H3PO4).

In a further preferred embodiment, the oral care product according to the invention contains a pH regulator in an amount of 0.05 to 3.0 Percent by weight, more preferably from 0.1 to 2.5 percent by weight, particularly preferably 0.2 to 1.5 percent by weight, based in each case on the total weight of the oral care product.

In a preferred embodiment, the oral care product according to the invention contains one or more flavorings which can give it the desired taste. These one or more flavorings can be natural, nature-identical, synthetic flavorings and/or mixtures thereof. Examples of flavorings are limonene, geraniol, citronellol and eugenol. In addition, flavorings can stimulate saliva, whereby the moisture in the saliva can have a positive effect on the remineralization of the tooth. An example of a salivary flavorant is pellitorin, particularly trans-pellitorin.

Flavorings can be contained in the oral care product according to the invention in an amount of 0 to 5% by weight, preferably 0.1 to 3% by weight, based on the total weight of the oral care product according to the invention.

Humectants are additives that prevent the oral care product according to the invention from drying out by binding water added during production (ie preventing evaporation) or by attracting atmospheric moisture during storage. Examples of humectants are glycerin, propane-1,2-diol, hexane

1.2-diol, egg yolk, aloe vera gel, honey, molasses, especially glycerin and hexane

1.2-diol. Moisturizers can be contained in the oral care product according to the invention in an amount of 0 to 25% by weight, preferably 0.1 to 20% by weight, based on the total weight of the oral care product according to the invention.

In a preferred embodiment, the oral care product according to the invention contains

- 0.01 to 80% by weight, preferably 0.2 to 40% by weight, more preferably 0.5 to 30% by weight, in particular 1.01 to 20% by weight of calcium phosphate compounds, preferably hydroxyapatite, - 0.00001 to 4.0% by weight, preferably 0.0001 to 1.0% by weight, particularly preferably 0.0005 to 0.1% by weight of methylxanthine, in particular caffeine,

- 0.3 to 3% by weight surfactants, preferably about 1.0% by weight sodium cocoyl glycinate or sodium methyl cocoyl taurate,

- 0.5 to 15% by weight, preferably 1 to 10% by weight, in particular about 7.0% by weight xylitol,

- 0 to 2.0% by weight, preferably 0.01 to 2.0% by weight, more preferably 0.05 to 1.0% by weight, of antimicrobial substance, in particular cetylpyridinium chloride and/or zinc chloride,

- 0 to 5% by weight, preferably 0.3 to 2.0% by weight, pH regulator, in particular phosphoric acid,

- 0 to 5% by weight, preferably 0.1 to 3% by weight, flavoring agent,

- From 0 to 25% by weight, preferably 0.1 to 20% by weight, of humectant, in particular glycerol and/or hexane-1,2-diol, the information in % by weight being based on the total weight of the oral care product. The remainder is distilled water, if any.

When the oral care product is in the form of an oral gel, it contains gelling agents, where the gelling agent consists of synthetic and/or natural polymeric materials.

It is advantageous here that the gelling agent is selected from the group containing cellulose and cellulose derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, agarose, agar, pectins, sclerotium gum, xanthan gum, guar gum, carrageenan, alginic acid , polyvinyl alcohol, polyvinylpyrrolidone and mixtures thereof.

Such an oral gel preferably contains gel formers in an amount of 1.0 to 4.0 percent by weight, particularly preferably 1.5 to 3.0 percent by weight and in particular about 2.0 percent by weight, based in each case on the total weight of the oral gel.

The pH is in the range of pH 5.0-9.0, preferably 6.5 to 7.5. The invention is explained below using examples.

Exemplary embodiments of the composition of oral care products according to the invention in the form of toothpastes (in % by weight):

Study 1: Effect of caffeine on the biological functions of human epidermal HaCaT keratinocytes (viability study) In order to investigate the effect of caffeine on the biological functions of human epidermal FlaCaT keratinocytes, cell experiments were carried out on human epidermal FlaCaT keratinocytes, with the following investigations being carried out :

1. P13-A biological test series 1 with two independent investigations 2. P13-B biological test series 2 with two independent investigations.

The initial cell number was 5,000 cells/well in 100 μl culture medium.

The culture medium was FlaCaT medium (DMEM supplemented with 10% FBS, 1% penicillin-streptomycin, 0.5% fungizone).

The treatment groups were as follows:

1. Control group (CTRL)

2. 0.00005% caffeine 3. 0.0001% caffeine

4. 0.0005% caffeine 5. 0.001% caffeine

6. 0.005% caffeine

The test duration was 24, 48 and 72 hours.

The investigation was carried out in the form of a colorimetric MTT investigation.

The results are in

Fig. 1 Results-P13-A Experiment 1

Fig. 2 Results-P13-A experiment 2

Fig. 3 Results - P13B experiment 1

Figure 4 Results - P13-B experiment 2 and shown.

The study found that none of the tested concentrations showed any cytotoxicity even when tested for 72 hours and that certain concentrations of caffeine increased the number of viable cells.

Study 2: Effect of caffeine on the biological functions of human epidermal FlaCaT keratinocytes (cell proliferation study)

In order to investigate the effect of caffeine on the cell proliferation of human epidermal FlaCaT keratinocytes, human FlaCaT keratinocytes were subjected to a CyQUANT viability test, with the following test series being carried out:

1. P22 Experiment 1 (biological test series 1)

2. P24 Experiment 2 (biological series 2).

The initial cell number was 5,000 cells/well in 1,500 µl culture medium.

The culture medium was FlaCaT medium (DMEM supplemented with 10% FBS, 1% penicillin-streptomycin, 0.5% fungizone). The treatment groups were as follows:

1. Control group (CTRL)

2. 0.00005% caffeine

3. 0.0005% caffeine

4. 0.005% caffeine

The test duration was 24, 48 or 72 hours.

The investigation was carried out using a fluorimetric CyQUANT assay, measuring the DNA content, which reflects cell proliferation.

The results are in

Fig. 5 Results CyQuant experiment 1&2 caffeine shown.

The study shows that caffeine appears to promote cell proliferation; the best proliferation-enhancing effects were seen after 72 hours.

Study 3: Effect of caffeine on the biological functions of human epidermal HaCaT keratinocytes (cell proliferation study)

To investigate the effect of caffeine on the biological functions of human epidermal HaCaT keratinocytes, human HaCaT keratinocytes were subjected to Q-PCR and ELISA, with the following series of experiments being carried out:

1. For Q-PCR: Determination of VEGF, HGF and EGF mRNA expression in cell lysates

2. For ELISA: Determination of VEGF, HGF and EGF protein synthesis/secretion in the culture medium

The initial cell count was

1. for Q-PCR: 140,000 cells/well in 1,500 μl culture medium

2. for ELISA: 140,000 cells/well in 1,500mI culture medium. The culture medium was HaCaT medium (DMEM supplemented with 10% FBS, 1% penicillin-streptomycin, 0.5% fungizone).

The treatment groups were as follows:

1. Control group (CTRL)

2. 0.00005% caffeine

3. 0.0005% caffeine

4. 0.005% caffeine

The test duration was for

1. Q-PCR 24 hours (simple treatment at time point 0 hours)

2. ELISA 48 hours (duplicate treatment at 0 h and 24 h without changing media).

The investigation took place

1. for Q-PCR by determining VEGF mRNA expression in cell lysates

2. for ELISA by determining VEGF protein synthesis/secretion in the culture medium.

The results are in

Fig. 6 Results-Experiment 1-Q-PCR-VEGF-24h Fig. 7 Results-Experiment 2-Q-PCR-VEGF-24h Fig. 8 Results-Experiment 1&2-ELISA-VEGF-48h Fig. 9 Results-Experiment 1 -Q-PCR-TGFß1-24h Fig. 10 Results-Experiment 2-Q-PCR-TGFß1 -24h Fig. 11 Results-Experiment 1-Q-PCR-TGFß2-24h Fig. 12 Results-Experiment 2-Q-PCR- TGFβ2 -24h Fig. 13 Results-Experiment 1-Q-PCR-GM-CSF-24h Fig. 14 Results-Experiment 2-Q-PCR-GM-CSF-24h Fig. 15 Results-Experiment 1&2-ELISA-GM-CSF -48h shown.

The study found - Q-PCR (24 hours treatment time) - Experiments 1 and 2: All caffeine concentrations seem to increase the mRNA expression of VEGF compared to the control group.

- ELISA (48 hours treatment time) - Experiments 1 and 2: 0.0005%

Caffeine increased the production/secretion of VEGF protein compared to the control group in both experiments. In Experiment 2, 0.005% caffeine was also effective.

Taken together, these data suggest that certain concentrations of caffeine increase the synthesis and production/secretion of VEGF in cultured human epidermal HaCaT keratinocytes.

The expression of HGF-specific mRNA, HGF-specific protein, TNFa-specific mRNA, TNFa-specific protein and TGFβ1-specific protein was below the detection limit in both experiments.

The experiments on GM-CSF show

- Q-PCR experiment (24 h treatment time) - Experiments 1 and 2: All caffeine concentrations tested apparently increased the mRNA expression of VEGF compared to the control group.

- ELISA (48 h treatment time) - Experiments 1 and 2: 0.0005% caffeine increased the production/secretion of VEGF protein compared to the control group in both experiments. In Experiment 2, 0.005% caffeine also showed an effect.

Taken together, these data strongly suggest that certain concentrations of caffeine increase the synthesis/production/secretion of VEGF in cultured human epidermal HaCaT keratinocytes.

Q-PCR experiment (24 h treatment time) - Experiments 1 and 2: None of the tested caffeine concentrations changed the mRNA expression of TGFß1 However, in experiment 2 certain caffeine concentrations evidently increase the mRNA expression of TGFß2.

- ELISA (48 h treatment time) - Experiments 1 and 2: The level of the TGFβ1-specific protein was below the detection limit in both experiments.

Taken together, these data suggest - despite the conflicting results in the two Q-PCR experiments - that caffeine most likely does not alter the synthesis/production/secretion of TGFß2 in cultured human epidermal HaCaT keratinocytes.

The experiments on TGFβ1 showed

- Q-PCR experiment (24 h treatment time) - Experiments 1 and 2: None of the tested caffeine concentrations changed the mRNA expression of TGFβ1

Taken together, these data suggest that caffeine does not alter TGFβ1 synthesis/production/secretion in cultured human epidermal HaCaT keratinocytes.

Claims

EXPECTATIONS

1. Oral care product, in particular toothpaste or mouthwash, characterized in that the oral care product contains a methylxanthine selected from the group consisting of caffeine, theobromine and theophylline and a calcium phosphate compound, preferably in particulate form, selected from the group consisting of monocalcium phosphate monohydrate (MCPM), Monocalcium phosphate anhydrate (MCPA), octacalcium phosphate (OCP), amorphous calcium phosphate (ACP), calcium-deficient hydroxyapatite (CDHA), hydroxyapatite (HA or HAP) and tetracalcium phosphate (TTCP), particularly preferably hydroxyapatite.

2. Oral care product, characterized in that the oral care product contains at least one compound selected from the group consisting of antibacterial substances, moisturizing or caring substances, desensitizing substances and abrasives.

3. Oral care product according to claim 1, characterized in that the oral care product contains methylxanthine in an amount of 0.00001 to 4.0 percent by weight, preferably 0.0001 to 1.0 percent by weight and particularly preferably 0.0005 to 0.1 percent by weight , each based on the total weight of the oral care product.

4. Oral care preparation according to one of the preceding claims, characterized in that the antibacterial substances include tin salts, chlorhexidine, cetylpyridinium chloride, triclosan, o-cymen-5-ol, enzymes, proteins and citrus extract.

5. Oral care product according to one of the preceding claims, characterized in that the moisturizing or caring substances are hyaluronic acid, hyaluronic acid salts, allantoin, panthenol, natural extracts and amino acids include.

6. Oral care products according to any one of the preceding claims, characterized in that the desensitizing substances include strontium salts.

7. Oral care product according to any one of the preceding claims, characterized in that the cleaning bodies comprise calcium carbonate and sodium bicarbonate.

8. Oral care product according to one of the preceding claims, characterized in that the oral care product contains at least one surfactant selected from the group consisting of taurates, glycinates, sarcosinates and quaternary ammonium compounds, preferably sodium methyl cocoyl taurate, sodium cocoyl glycinate, sodium lauroyl sarcosinate, benzalkonium chloride or cetyl piridinium chloride.

9. Oral care product according to one of the preceding claims, characterized in that the oral care product contains calcium phosphate compounds in an amount of 0.01 to 80% by weight, preferably 0.1 to 20% by weight, particularly preferably 1 to 10% by weight and in particular 1 to 5% by weight based on the total weight of the oral care product.

10. Oral care product according to one of the preceding claims, characterized in that the oral care product contains at least one calcium compound selected from the group consisting of calcium carbonate, calcium chloride, calcium bromide, calcium nitrate, calcium acetate, calcium gluconate, calcium lactate, calcium tartrate and their hydrates and mixtures thereof, preferably calcium carbonate .

11. Oral care product according to one of the preceding claims, characterized in that the oral care product is free from fluorides and/or tin salts and/or chlorhexidine and/or cetylpyridinium chloride and/or triclosan.