EP4277709A1

EP4277709A1 - Dental care product

Info

Publication number: EP4277709A1
Application number: EP22700529.5A
Authority: EP
Inventors: Frederic Meyer; Joachim Enax; Erik Schulze Zur Wiesche
Original assignee: Dr Kurt Wolff GmbH and Co KG
Current assignee: Dr Kurt Wolff GmbH and Co KG
Priority date: 2021-01-15
Filing date: 2022-01-11
Publication date: 2023-11-22
Also published as: CA3205338A1; DE102021100811A1; WO2022152347A1

Abstract

The present invention relates to a dental care product, especially a toothpaste, comprising calcium phosphate compounds. In order to provide a biomimetic or bioinspired dental care product, especially for prophylaxis of caries and for gentle and simultaneously effective tooth cleaning, that avoids the disadvantages of the prior art, it is proposed in the context of the invention that the dental care product be free of fluorine compounds and free of silicon compounds and contain at least one surfactant selected from the group consisting of taurates, glycinates or sarcosinates. The dental care product advantageously remineralizes relatively small caries lesions and/or repairs microfine defects in the enamel, especially also in patients having a dry mouth/lack of saliva.

Description

DESCRIPTION

dentifrices

The present invention relates to a dentifrice, in particular a toothpaste, containing at least one calcium phosphate compound.

The term "dental care products" in the sense of the present patent application means toothpastes, tooth gels and polishing pastes.

A toothpaste, also referred to as toothpaste, can be used in combination with a toothbrush for mechanical tooth cleaning and is a soft or semi-solid composition for oral use, particularly on the teeth and/or gums.

Dental care is becoming more and more important, if only because of the increasingly carbohydrate-rich diet worldwide. In addition to aesthetic aspects, special emphasis is increasingly being placed on preventive care, with the focus here being primarily on reducing or even avoiding plaque, caries and/or halitosis (bad breath) and healthy gums.

The gums are characterized, among other things, by the fact that they cervically surround the teeth. The gums enclose the neck of the tooth, which seals the entry point of the tooth into the jawbone of the oral cavity. The gums serve, among other things, to protect and hold the tooth.

The different parts of a natural tooth are the tooth crown, tooth neck and tooth root, which are made up of several layers. Of these layers, one normally only sees the outer enamel (enamel), which encloses the dentine and other layers. For example, in order to be able to bite or grind food without damaging the teeth, the tooth enamel is very hard. It consists of about 97% by weight of hydroxyapatite (HAP), which has the empirical formula Cas(PO4)3(OH). The dentin is also considered to be the hard tooth substance and also consists of about two thirds of hydroxyapatite. In addition to hydroxylapatite, dentin also contains proteins (eg collagen) and water and is therefore softer than tooth enamel.

Dental diseases such as caries can be based on the formation of bacterial microfilms and/or on bacterial inflammation. Although preventive care is often preventable, caries remains one of the most common chronic diseases in children and there is a great need for products to prevent and cure teeth affected by caries, especially among poorer children worldwide.

It is documented that saliva has a remineralizing effect due to its oversaturation of Ca ²⁺ and PO4 ³ ' ions in bioavailable form. However, the remineralizing effect brought about by the saliva is not only slow, but also apparently insufficient to protect people from caries and/or to remineralize existing tooth lesions without the addition of remineralization-enhancing additives.

Caries is considered to be a disease dependent on several influences, in particular of tooth enamel and dentin, with the participation of microorganisms. In a first step, a precipitate, also called pellicle, can form on the tooth surface, including saliva protein. The rougher the tooth surface, the easier it is for the deposit to form or adhere to it. After some time, this pellicle forms a film that covers the tooth surface and is a few microns thick. Bacteria can then continue to multiply and spread on this film, whereby this film can be regarded as a biofilm. Furthermore, the bacteria mentioned can produce organic acids, such as gluconic and lactic acid, from the low-molecular carbohydrates frequently found in today's food. Both these organic acids produced by bacteria and the acids supplied through food, such as fruit acids, can cause erosion of the cause hard tooth substance. Here, among other things, calcium phosphates are dissolved from the tooth enamel. If this process is not stopped or preferably even reversed, demineralization of the tooth enamel and possibly also the dentin can occur after some time. A defect in the hard tooth substance that arises in this way is referred to as a carious lesion, with carious lesions on the dentin layer being recognizable, for example, by a yellow to brown discoloration of the corresponding part of the tooth. So while carious lesions on the tooth enamel can often be reduced or eliminated simply by renewed mineralization of the tooth enamel, in the case of carious lesions that affect other layers in addition to the tooth enamel, the damaged part of the tooth is usually removed and the resulting hole (caries lesion ) closed with a filling material. In summary, it can be said that caries formation can be favored by the interaction of the following factors:

- special bacteria sticking to the pellicle poor tooth quality or mineral quality of the tooth plaque

- food containing low molecular weight carbohydrates

- Time: Studies also indicate that the hydroxyapatite nanoparticles produced by the natural abrasion of tooth enamel can intervene in biofilm management, with this abrasion falling sharply when switching from protein-rich to carbohydrate-rich food.

One possibility for caries prophylaxis could accordingly lie in the supply of calcium phosphate compounds, in particular hydroxylapatite. In addition, there are different approaches, all aimed at preventing tooth decay, in order to avoid the above treatments. Caries prophylaxis with fluoride-containing dental care products can be regarded as the current standard. JM ten Cate: "Contemporary perspective on the use of fluoride products in caries prevention", British Dental Journal, February 23, 2013, vol. 214, no. 4, pp. 161-167, describes the use and mode of action in a review article of fluoride-containing dental care products such as toothpaste and mouthwash dental care products the reduction of tooth decay is achieved through their regular use. As a model, it is assumed that fluoride accelerates the natural remineralization from the saliva.

Various fluoride compounds, such as, for example, sodium fluoride, tin fluoride, amine fluorides and monofluorophosphates, are suitable as fluoride sources in the dental care products mentioned. J. M. ten Cate: "The Need for Antibacterial Approaches to Improve Caries Control", Adv Dent Res 21 :8-12, August 2009, pp. 8-12, deals with the fact that the provision of fluoride alone may not be enough to ensure adequate caries prevention because, as mentioned above, bacteria also play a crucial role in the formation of caries. However, the fluoride ion itself does not show a pronounced antimicrobial effect against bacteria that can cause caries should contain one or more antimicrobial substance(s), such as chlorhexidine (CHX), whose antimicrobial effect in the oral cavity has been investigated in many studies.

However, the use of fluorides in dental care products is also discussed controversially, as negative side effects are feared. One of these is called dental fluorosis, which is caused by excessive fluoride intake during tooth formation. Acute toxic effects include nausea, vomiting and diarrhea. Other examples are bone fluorosis, which manifests itself in the thickening of the outer bone layer and the associated loss of elasticity and resilience of the bones, and enamel fluorosis, which can be recognized by the appearance of whitish enamel spots on the tooth surface. In addition, it is reported that swallowing high-dose dental care products can trigger acute fluoride poisoning, especially in children, which can sometimes even be fatal (Bashash, M. et al. Prenatal fluoride exposure and cognitive outcomes in children at 4 and 6-12 years of age in Mexico. Environ. Health Perspect. 125, 097017 (2017)). Furthermore, it is reported that the WHO is not able to set a value for a daily fluoride requirement because fluoride is not an essential trace element and therefore it is not diagnostic parameters and no evidence for the existence of clinical symptoms of "fluoride deficiency".

The use of an antimicrobial substance such as chlorhexidine in dental care, especially in caries prophylaxis, is also controversial. It was reported that a relevant effect for caries prophylaxis is not always reproducible and only occurs in some of the cases examined. Furthermore, the antimicrobial effect of chlorhexidine is not limited to the bacteria in the mouth that contribute to caries formation, but also includes beneficial bacteria. In addition, long-term treatment with products containing chlorhexidine leads to undesirable side effects such as tooth discoloration and taste disorders. Biomimetic tooth and mouthwash solutions with artificial tooth enamel can contain zinc carbonate hydroxyapatite, for example. This zinc carbonate hydroxyapatite is also known commercially as Microrepair. Zinc-carbonate-hydroxyapatite-based products can reduce the initial bacterial colonization on the enamel surface without having antimicrobial properties that can disturb the ecological balance of the oral cavity. In addition, these products are intended to serve, among other things, for remineralization and the repair of microfine defects in tooth enamel and the formation of a protective layer.

Due to the above limitations in both the salivary homeostatic mechanism and fluoride-based approaches to caries prevention and remineralization, there is a need for alternative strategies that are at least equivalent to the efficiency of fluoride addition in remineralization without the corresponding undesirables show side effects.

There are also biometric dental care products based on the use of hydroxyapatite. For example, DE 10 2020 001 823 A1, WO 2018/024649 A1, DE 10 2017 009 626 A1 and DE 10 2018 102 365 describe oral care compositions which contain synthetic hydroxyapatite, as indicated above, hydroxyapatite is a bioactive and biocompatible material having a similar chemical composition to the apatite of human tooth enamel. However, these compositions contain cetylpyridinium chloride, which is disadvantageous because of its bitter taste.

However, there remains a need for the use of a dentifrice for the treatment or prevention of a variety of dental disorders which product can also be used to remineralize subsurface lesions. In other words, the use of the dentifrice should not only provide a way of preventing or treating numerous dental diseases, in particular caries, but also remineralization in deeper layers or cavities of the tooth enamel (deep mineralization), which cannot be guaranteed with conventional products, in particular those containing fluoride can.

Toothpaste according to the prior art contains abrasives, also referred to as cleaning bodies or abrasives, which remove plaque and harmful bacteria from the tooth surface during the tooth cleaning process, usually together with the toothbrush, and can also provide a brightening (whitening effect). Toothpastes contain abrasives or abrasives in an amount of up to 15% by weight or more, based on the total weight of the toothpaste. Examples of abrasives are whitewash, marble powder and/or silicate compounds such as silica. Polysilicic acids (Hydrated Silica I Silica) and calcium carbonate are most commonly used worldwide. The disadvantage is that, with the exception of calcium phosphate compounds (e.g. hydroxyapatite), all cleaning body types are foreign to the body and do not correspond to the natural tooth mineral (hydroxyapatite). For example, in the case of cleaning bodies with a high relative hardness, the hard tooth substance can be irreparably damaged. If the cleaning body is too low in hardness, the cleaning performance of the toothpaste formulation as a whole may be too low to effectively remove plaque during tooth brushing (increased risk of caries and periodontitis). Furthermore, when using the product, the ecological balance in the oral area should not be significantly disturbed and/or tooth discoloration or taste disturbances should not be at risk.

The object of the invention is to create a dental care product, in particular a toothpaste, with one or more biomimetic or bioinspired active ingredient(s), in particular for the prevention of caries, which avoids the disadvantages of the prior art described above. In particular, a dental care product, in particular a toothpaste, is to be provided which remineralizes existing, smaller caries lesions and/or repairs microfine defects in the tooth enamel. Furthermore, a protective layer should be applied to the tooth and/or open dentine tubules should be closed. To this end, the above-mentioned effects should be achieved, with the aim being to avoid the disadvantages that can be associated with the use of fluoride. Furthermore, the adhesion of bacteria on the tooth enamel should advantageously be reduced without significantly disturbing the ecological balance in the oral cavity and/or risking tooth discoloration or taste disturbance. The dental care product should also not have any irritating effect on the mucous membranes.

These objects are achieved with a dental care product, in particular a toothpaste, according to the generic term in that the dental care product is free from fluoride compounds and free from silicon compounds and contains at least one surfactant selected from the group consisting of taurates, glycinates and sarcosinates.

The dental care product according to the invention is preferably in the form of a toothpaste. It contains no fluoride compounds and is therefore fluoride-free. The problems of toothpastes containing fluoride described above (dental fluorosis, bone fluorosis, impairment of neuronal development in children in the womb (Bashash, M. et al. Prenatal fluoride exposure and cognitive outcomes in children at 4 and 6-12 years of age in Mexico. Environ. Health Perspect . 125, 097017 (2017)), etc.) are thus avoided. The dentifrice according to the invention is also free from silicon compounds (eg silica/polysilicic acid/hydrated silica). It has surprisingly been found within the scope of the invention that the calcium phosphate compounds alone fulfill an excellent cleaning function, so that the presence of silicon compounds in the dentifrice can be dispensed with entirely. With such a dental care product, excellent caries protection is achieved without mechanically damaging the teeth, such as with conventional cleaning agents in the form of polysilicic acids, aluminum oxide, perlite, titanium dioxide, etc.

Furthermore, the dental care product according to the invention contains at least one surfactant selected from the group consisting of taurates, glycinates and sarcosinates. Anionic, nonionic, cationic and zwitterionic surfactants can be used as surfactants, with nonionic surfactants often being avoided because of their adverse effects on the antibacterial compound; likewise, cationic and zwitterionic surfactants are often avoided as they stain or darken teeth.

The dentifrice according to the invention is free from sodium lauryl sulphate and cetylpyridinium chloride and instead contains other surfactants which do not irritate the mucous membranes, such as taurates, preferably sodium methyl cocoyl taurate, glycinates, preferably sodium cocoyl glycinate and sarcosinates, preferably sodium lauroyl sarcosinate. The specification of the respective surfactants also includes all variants thereof (different alkyl chains, branches in the alkyl chains, counterions, etc.). Surfactants are important for a toothpaste because they help distribute the active ingredients in the oral cavity while brushing your teeth. Surfactants are also important for consumer convenience.

For example, sodium lauryl sulfate-free and cetylpyridinium chloride-free dentifrices may be important for people with sensitive or irritated gums (eg, children, gingivitis/periodontitis patients, people with xerostomia/hyposalivation). Sodium lauryl sulfate and silica are the most potent for fighting plaque Active ingredients in cosmetic oral care preparations. In the present invention, the disadvantages of these two active ingredients (sodium lauryl sulfate: irritating to the mucous membranes; silica: potentially damaging to teeth, not remineralizing) could be overcome for the first time; ie cleaning that is equally gentle on the mucous membrane and teeth, but effective at the same time as having an effective remineralising, antibacterial and caries-protecting effect.

In particular, it was unexpectedly found that the dental care product according to the invention advantageously remineralizes smaller caries lesions and/or repairs microfine defects in the tooth enamel, especially in patients with dry mouth/lack of saliva. Furthermore, the composition according to the invention can be used to apply a protective layer to the tooth, and it has also been found that the tooth enamel has advantageous solubility and resistance to acids after the composition according to the invention has been used. In addition, antimicrobial substances (e.g. chlorhexidine) as auxiliary substances can be dispensed with in the present composition. In this way, excellent caries prophylaxis can be guaranteed without, for example, disturbing/destroying the bacterial balance in the oral cavity and without risking unpleasant side effects.

In particular, it was unexpectedly found that the dental care product according to the invention prevents caries and lesions can also be remineralized down to the deeper layers of the tooth, in particular the tooth enamel. Furthermore, the dental care product according to the invention can be used to apply a protective layer to the tooth and over exposed dentin, and in particular to close open dentinal tubules. Furthermore, it was found that the tooth enamel after the application has a significantly reduced or no longer detectable structural damage. In addition, the use of fluoride can be completely dispensed with with the present dentifrice. In this way, the above positive aspects can be guaranteed without, for example, disturbing/destroying the bacterial balance in the oral cavity and without undesired side effects, which occur, for example, when using fluoride-containing Oral care products may occur at risk. The object of the present invention is a dentifrice for the mineralization of teeth, in particular tooth enamel, to a depth of 200 μm, preferably up to 100 μm (deep mineralization).

It is preferred that the at least one calcium phosphate compound is preferably in particulate form and is selected from the group consisting of monocalcium phosphate monohydrate (MCPM), monocalcium phosphate anhydrate (MCPA), dicalcium phosphate dihydrate (DCPD, brushite), dicalcium phosphate anhydrate (DCPA , monetite), octacalcium phosphate (OCP), a-tricalcium phosphate (a-TCP), ß-tricalcium phosphate (ß-TCP), amorphous calcium phosphate (ACP; also known as CPP-ACP complex = casein phosphopeptide - amorphous calcium phosphate), amorphous calcium phosphate ( ACP), calcium-deficient hydroxyapatite (CDHA), hydroxyapatite (HA or HAP), tetracalcium phosphate (TTCP) and calcium pyrophosphate, particularly preferably from hydroxyapatite and calcium pyrophosphate. The at least one calcium phosphate compound can be present in different crystal forms, also in the form of mixtures of these crystal forms, with more round crystal forms being preferred over more pointed crystal forms (e.g. needle-shaped crystals). They can also have different crystal and aggregate sizes, also in mixed form, and have different crystallinities, also in mixed form.

Hydroxyapatite (Cas(PO4)3(OH)) is also known as hydroxyapatite. It is a mineral from the mineral class of phosphates, which crystallizes in a hexagonal crystal system. In addition, hydroxyapatite is a member of the apatite group and forms a complete mixed series with chlorapatite and fluorapatite.

A Cas(PO4)3(OH) suitable according to the invention is described, for example, in DE 10 2016 114 189.5. The Cas(PO4)3(OH) used according to the invention is preferably produced synthetically. This means that the Cas(PO4)3(OH) used according to the invention is preferably not produced by burning out the organic Components derived from animal material such as bones.

The calcium phosphate compounds used according to the invention can be present both in pure form and in the form of substituted compounds and as mixtures thereof. A pure form is present according to the invention when the ions contained in the respective calcium phosphate compound are each less than 1%, preferably less than 0.5%, even more preferably less than 0.1% substituted by one or more other ions. For example, in pure hydroxyapatite, the Ca ²⁺ ions are substituted by, for example, Mg ²⁺ or Zn ²⁺ to an extent of less than 1%, preferably less than 0.5%, even more preferably less than 0.1%.

Furthermore, the calcium phosphate compounds according to the invention preferably contain no doping, such as, for example, a zinc carbonate doping. However, doped calcium phosphate compounds can also be used.

The Xso value of the volume-based particle size distribution of the calcium phosphate compounds is 1.0 nm to 100.0 pm, preferably 10 nm to 10.0 pm, more preferably 50 nm to 1 pm, particularly preferably 100 nm to 5500 nm, the Xso -Value of the volume-based particle size distribution is measured using laser diffraction.

For this purpose, a sample of the calcium phosphate compounds is first sonicated in an ultrasonic homogenizer with an energy output of 96 W for 9 minutes and then for a further 3 minutes in a device for sample preparation. The subsequent particle size distribution measurement (laser diffraction) is carried out in a particle size determination instrument at a temperature of 25°C ± 0.3°C and the corresponding values are calculated according to the Mie theory. The measuring instruments used are exclusively commercially available devices.

In a preferred embodiment of the invention, the calcium phosphate compound is Cas(PO4)3(OH) and has a hexagonal crystal lattice on, in which the length of the a-axis is 0.930 to 0.950 nm, preferably 0.933 to 0.948 nm, particularly preferably 0.936 to 0.945 nm and the length of the c-axis is 0.680 to 0.700 nm, preferably 0.682 to 0.696 nm, particularly preferably 0.685 to 0.692 is nm. The lengths of the a-axis and the c-axis are determined by a Rietveld evaluation of the corresponding X-ray powder diffractograms. The X-ray powder diffractograms themselves are obtained by means of a measurement using a conventional powder diffractometer with the routine settings.

In a preferred embodiment of the invention, the at least one calcium phosphate compound is in aggregated form. In this case, aggregation is understood to mean the accumulation of molecules or particles to form a larger association, the aggregate. This assembly or aggregation is brought about and held together by various forces and/or types of bonding, such as ionic bonding, van der Waals forces, intermolecular forces or other types of chemical bonding. The degree of aggregation and also the size of the aggregate can be determined using scanning electron microscopy.

The dentifrice according to the invention comprises calcium phosphate compounds in an amount of 0.01 to 80% by weight, preferably 0.1 to 20% by weight, particularly preferably 1 to 10% by weight and in particular 1 to 5% by weight on the total weight of the dentifrice. The preferred amount of calcium phosphate compounds is 1 to 5% by weight for mouthwashes and 10 to 20% by weight for toothpastes, based in each case on the total weight.

The at least one surfactant is preferably selected from the group consisting of sodium methyl cocoyl taurate, sodium cocoyl glycinate, sodium lauroyl sarcosinate and sodium myristoyl sarcosinate.

The dentifrice according to the invention preferably contains at least one calcium compound selected from the group consisting of calcium carbonate, calcium chloride, calcium bromide, calcium nitrate, calcium acetate, calcium gluconate, Calcium lactate, calcium tartrate and their hydrates and mixtures thereof, preferably calcium carbonate.

The dentifrice according to the invention preferably contains no perlite. Perlite is a abrasive with a high relative hardness and can damage teeth.

The dental care product according to the invention preferably contains no aluminum compounds. Aluminum compounds can be potentially toxic.

The dental care product according to the invention preferably contains no diamond particles. Diamond is a abrasive with a high relative hardness and can damage teeth.

The dental care product according to the invention preferably contains no cellulose fibers (microcrystalline cellulose=cleaning particles). Cellulose fibers often lead to an unpleasant feeling in the mouth, so that user compliance is severely limited.

The dentifrice according to the invention preferably contains no sodium bicarbonate. Sodium bicarbonate has only a very low cleaning capacity.

The dentifrice according to the invention preferably contains no glucosides. Glucosides can split off glucose, which favors the unwanted development of caries.

The oral care according to the invention does not contain any abrasive polymer particles/"microbeads" (e.g. polyethylene beads). Such polymer particles can have harmful effects on the environment.

The dentifrice according to the invention preferably contains no sulfates, such as sodium lauryl sulfate, or sulfonates. The dental care product according to the invention is used for the remineralization of teeth to a depth of 200 μm, preferably up to 150 μm, in particular up to 100 μm. Such a remineralization of teeth down to these depths is referred to as deep mineralization, since in this case not only the tooth surface areas down to a depth of approx. 30 μm, as described in the prior art, but also deeper areas of the tooth are remineralized.

It has been found that the dentifrice of the present invention can be used in the treatment and/or prevention of numerous dental disorders.

In a preferred embodiment of the invention, the dental care product according to the invention can be used to treat (dental) diseases/conditions selected from caries, tooth erosion, tooth abrasion/attrition, bruxism, molar incisor hypomineralization (MIH), amelogenesis imperfecta, dentinogenesis imperfecta and fluorosis.

The term caries is familiar to those skilled in the art. Caries is generally understood to be a destructive disease of hard tooth tissue, tooth enamel and dentine.

Tooth erosion is understood to mean damage to the tooth structure by acids, in other words defects in the enamel and/or dentin caused by dental erosion, which, if treated too late, can lead to irreversible damage.

(Tooth) abrasion is understood to mean the loss of tooth structure through friction. Attrition is a subtype of abrasion, namely the loss of tooth structure through reflective touching of the teeth.

Bruxism is the unconscious grinding or clenching of teeth, mostly at night, but also during the day Teeth but also the periodontium and chewing muscles can be worn out.

Molar incisive hypomineralization (MIH), also known as "chalk teeth", is an enamel disorder, i.e. structural damage to the enamel.

Amelogenesis imperfecta is considered to be a genetic disease in which tooth enamel formation is disrupted. As a result, the teeth have an increased risk of caries formation and are particularly sensitive to temperature.

Dentinogenesis imperfecta is an autosomal dominant inherited malformation/structural disorder of dental dentition, which occurs in approximately 1 in 8000 people and results in severe tooth abrasion.

Tooth (fluorosis) (also: dental fluorosis) is a non-inflammatory disease (“mottled teeth”), which is caused by excessive fluoride intake, particularly during the ontogenetic development of the teeth. It has been found that the above tooth (diseases) can be prevented and/or their progression at least significantly slowed down and/or complete restoration of the tooth substance, in particular the hard tooth substance, can be achieved by the use according to the invention. In particular, it was found that the use according to the invention or after its application shows significantly reduced or no longer detectable structural damage to the tooth enamel.

In a preferred embodiment, the dental care product according to the invention can be used to treat code 3 or code 4 caries, preferably code 3 caries, determined according to the International Caries Detection and Assessment System (ICDAS).

According to the International Caries Detection and Assessment System (ICDAS). Caries is divided into different codes (levels), whereby the higher the code, the stronger the caries infestation on the tooth and consequently its effects on this tooth.

With a code 0 caries, no signs of caries are visible after drying in the air stream for about 5 seconds.

In the case of code 1 caries, the first visual changes in the enamel surface are visible after the tooth has dried. The changes can be opacity, whitish or brownish discolouration.

In the case of code 2 caries, clear visual changes in the enamel surface are already present on the moist tooth. These changes can be opacity in the sense of a white spot lesion and/or brownish carious discolouration in the fissures/pits and must still be visible on the dried tooth.

In code 3 caries, there is demineralization or loss of the enamel structure without visible changes in the dentin. The opacities and/or brownish or black carious changes extend beyond the border of the fissures/pits and are visible even after the tooth has dried. If necessary, a WHO probe can be carefully passed over the enamel defect to palpate the discontinuity of the enamel surface.

In code 4 caries, there is shadowing in the dentin, with or without enamel collapse. Shadow formation can be greyish, bluish or brownish.

Code 5 caries shows clear cavity formation with visible dentin. The loss of enamel is clearly visible on the dried tooth. If necessary, the WHO probe can be used to palpate the exposed dentine. With code 6 caries, there is extensive cavitation, with the dentine clearly visible in the width and depth of the tooth. At least half of the enamel surface has been destroyed by caries. The pulp can be affected.

In a preferred embodiment, the dental care product according to the invention can be used both for cosmetic and for medical purposes. This means that it can be used not only for the treatment of the above-mentioned (dental) diseases, but also for cosmetic purposes such as beautifying the appearance of the teeth.

In a preferred embodiment, the dental care product according to the invention is used in people of all ages, including children, in the case of children preferably in children aged 6 months to 14 years, in particular in children aged 10 months to 12 years.

In a preferred embodiment, the Cas(PO4)3(OH) contained in the dental care product according to the invention is the only apatite component of the dental care product.

In a preferred embodiment, the dental care product according to the invention comprises 0.01 to 80% by weight, preferably 0.2 to 40% by weight, more preferably 0.5 to 30% by weight, in particular 1.0 to 20% by weight of calcium phosphate compounds in one In a preferred embodiment of the invention, the dental care product according to the invention can contain 1% by weight, 2% by weight, 3% by weight, 4% by weight, 5% by weight, 6% by weight, 7% by weight, 8% by weight, 9% by weight %, 10%, 11%, 12%, 13%, 14%, 15%, 20% or 25% by weight of calcium phosphate compounds.

In a preferred embodiment, the dental care product according to the invention comprises one or more calcium salts which have a solubility of at least 10 mg/l H2O at 20°C. The solubility is according to the methods known to those skilled in the art or can be taken from the relevant technical literature.

In a preferred embodiment, the dental care product according to the invention can contain one or more pharmaceutical or cosmetic ingredients. These pharmaceutical or cosmetic ingredients are described, for example, in Toothpastes, Monographs in Oral Science, Vol. 23, 1st edition, 2013.

Preferably, the one or more pharmaceutical or cosmetic ingredients include xylitol, antimicrobials, pH regulators, abrasives, flavorings, and humectants, particularly xylitol, pH regulators, abrasives, and flavorings.

Xylitol can minimize the number of caries bacteria and inhibit their growth. Xylitol can also stimulate salivation. The increased amount of saliva produces an increased amount of phosphate. This phosphate can react with the calcium(ions) from the dental care product according to the invention to form hydroxyapatite. The dentifrice according to the invention can contain xylitol in an amount of 0.5 to 15% by weight, preferably 1 to 10% by weight, in particular about 7.0% by weight, based on the total weight of the dentifrice. In addition to xylitol, the dental care product according to the invention can contain other sugar alcohols such as sorbitol.

Antimicrobial substances are substances that can kill microorganisms, such as bacteria, or greatly reduce their reproduction. In addition to antimicrobial substances with a non-specific defense against bacteria and fungi, there are also those that only work against targeted bacteria, for example. The use of antimicrobial substances can also combat bad breath, for example. Antimicrobial substances can preferably be present in the dentifrice according to the invention in an amount of 0.01 to 2.0% by weight, preferably 0.05 to 1.0% by weight. Examples of the antimicrobial substances used in oral care are zinc compounds, such as zinc chloride and zinc citrate as well as essential oils and surfactants.

In a particularly preferred embodiment, the dental care product according to the invention contains no chlorhexidine.

In a particularly preferred embodiment, the dental care product according to the invention does not contain any triclosan. pH regulators are substances that can set a specific pH range, preferably a range from pH 6.5 to 7.5. If the composition was too acidic, there would be a risk of demineralization of the tooth structure (erosion). Examples of pH regulators are sodium hydroxide (NaOH) or phosphoric acid (H3PO4), which can be used according to the desired pH value. Sodium hydroxide can be added to raise too low a pH, while phosphoric acid can be added if the pH is too high. pH regulators can be up to 5% by weight, based on the total weight of the dental care product according to the invention.

In a preferred embodiment, the dental care product according to the invention contains one or more flavorings which can give it the desired taste. These one or more flavorings can be natural, nature-identical, synthetic flavorings and/or mixtures thereof. Examples of flavorings are limonene, geraniol, citronellol and eugenol. In addition, flavorings can stimulate saliva, whereby the moisture in the saliva can have a positive effect on the remineralization of the tooth. An example of a salivary flavorant is pellitorin, particularly trans-pellitorin.

Flavorings can be contained in the dental care product according to the invention, preferably in an amount of 0 to 5% by weight, preferably 0.1 to 3% by weight, based on the total weight of the dental care product according to the invention. Humectants are additives which prevent the dental care product according to the invention from drying out by binding water added during manufacture (ie preventing evaporation) or by attracting atmospheric moisture during storage. Examples of humectants are glycerin, propane-1,2-diol, hexane

1.2-diol, egg yolk, aloe vera gel, honey, molasses, especially glycerin and hexane

1,2-diol. Moisturizers can be contained in the dental care product according to the invention in an amount of 0 to 25% by weight, preferably 0.1 to 20% by weight, based on the total weight of the dental care product according to the invention.

In a preferred embodiment, the dental care product according to the invention contains

- 0.01 to 80% by weight, preferably 0.2 to 40% by weight, more preferably 0.5 to 30% by weight, in particular 1.01 to 20% by weight of calcium phosphate compounds, preferably hydroxyapatite,

- 0.3 to 3% by weight of surfactants, preferably about 1.0% by weight of sodium cocoylglycinate or sodium methyl cocoyltaurate,

- 0.5 to 15% by weight, preferably 1 to 10% by weight, in particular about 7.0% by weight xylitol,

- 0 to 2.0% by weight, preferably 0.01 to 2.0% by weight, more preferably 0.05 to 1.0% by weight, of antimicrobial substance, in particular zinc chloride,

- 0 to 5% by weight, preferably 0.3 to 2.0% by weight, pH regulator, in particular phosphoric acid,

- 0 to 5% by weight, preferably 0.1 to 3% by weight, flavoring agent,

- From 0 to 25% by weight, preferably 0.1 to 20% by weight, of humectants, in particular glycerol and/or hexane-1,2-diol, the information in % by weight being based on the total weight of the dentifrice. The remainder is distilled water, if any.

The pH is in a neutral range from pH 6.5 to 7.5. The invention is explained below using examples.

Embodiments of the composition of the invention

Dentifrices in the form of toothpastes (in % by weight):

study

A study was made on properties of a toothpaste according to the invention.

Example 1 :

A toothpaste not according to the invention was produced, which contains the following components: demineralized water 55.30% by weight,

Hydrogenated starch hydrolyzate 21.60% by weight,

Hydrated silica 2.00% by weight (Grace, SM 850 C)

hydroxyapatite 10.00% by weight,

Xylitol 7.00% by weight, sodium carboxymethyl cellulose 0.80% by weight,

hexane-1,2-diol 0.40% by weight,

Flavor 0.40% wt.

The toothpaste is a light beige, homogeneous, creamy paste with an average pH of 7.2. character list

1 shows a flowchart with the step-by-step methodology. This is a crossover study, so the 30 subjects who completed the study received the two procedures in a crossover design as Phase I & II.

Figure 2 shows representative microradiographic images of healthy tooth tissue before (A) and after (B) intra-oral exposure for demineralization while the subject uses a children's toothpaste (Karex) containing 10% hydroxyapatite in the form of microclusters.

Figure 3 shows representative microradiographic images of healthy tooth tissue before (A) and after (B) intra-oral exposure for demineralization while the subject used a children's toothpaste (Elmex) containing 500 ppm fluoride as amine fluoride.

Figure 4 shows representative microradiographic images of subsurface enamel lesions (initial caries lesions) before (A) and after (B) in situ remineralization by treatment of a children's toothpaste (Karex) containing 10% hydroxyapatite in the form of microclusters. Figure 5 shows representative microradiographic images of subsurface enamel lesions (initial carious lesions) before (A) and after (B) in situ remineralization by treatment of a children's toothpaste (Elmex) containing 500 ppm fluoride as amine fluoride.

way of study

In a randomized, double-blind, single-center, in situ controlled, crossover study, two children's toothpaste formulations containing either 10% hydroxyapatite in the form of microclusters or 500 ppm fluoride provided as amine fluoride (AMF) were evaluated for their ability to induce remineralization and the development of initial caries lesions to prevent, compared with each other.

T est person selection

The study enrolled 32 people of mixed races, ages 18 to 60, who were not taking antibiotics or drugs that affect salivation, had at least 20 natural, uncapped teeth, and who had a history of tooth decay, but who were beginning to study had no clinically active caries. In addition, the subjects had no dental and/or gum disease, were not pregnant or breastfeeding, and did not smoke tobacco products.

Creation of artificial initial caries and fabrication of the in situ device

32 freshly extracted human deciduous teeth without caries, cracks or enamel defects were selected and cleaned. Four tooth blocks were prepared from the buccal and lingual surfaces of each of the selected teeth, each of the blocks being approximately 2mm in length, 2mm in width and 1.5mm in depth. Two blocks were retained as healthy blocks for demineralization prevention assessment, while the two blocks designated for remineralization assessment were artificially induced to begin with. All sides of each block were coated in two coats of acid-resistant nail polish except for the buccal and lingual surfaces, respectively, on which an initial carious lesion (demineralization) was created by subjecting the exposed surface to an acidified gel system (0.1 M lactic acid, 0. 1 M sodium hydroxide, 60% w/v hydroxyethyl cellulose, pH 4.5). The nail polish was then carefully removed with acetone. A tooth section approximately 150 µm thick was cut from each tooth block to measure the baseline mineral loss (Az-i) and lesion depth (LD1 ) of each induced initial carious lesion and to select the lesions suitable for remineralization evaluation. Sections were prepared for transverse microradiography as follows. Both sides of the coupons were polished using lapping film in a MultiPrep ^™ precision polishing machine Allied High Tech polishes to create plane-parallel surfaces and reduces section thickness to 100 pm. Sections were then microradiographed on a Type 1A high resolution glass X-ray plate from Microchrome Technology, CA, USA using a Philips X-ray generator with the appropriate settings. The plates were exposed to radiation for 10 minutes at an anode voltage of 20 kV and a tube current of 10 mA and then further processed, the further processing consisting of a 5-minute development in a Kodak HR developer, a 15-minute fix with a fixing agent (Kodak Rapid-fixer ) and a thirty minute wash. After drying, the microradiographs were examined under an optical microscope (Leica DMR) connected to a PC via a camera (Sony; model XC-75 CE CCTV). Using image analysis software (TMR2006 version 3.0.0.11; Inspector Research Systems, Amsterdam), the magnified image of the microradiographs was analyzed under standard conditions of light intensity and magnification together with the image of a step wedge described in the literature. Then the images were only used to select the lesions suitable for the comparison experiment. Only those samples that had caries-like surface lesions that displayed a reasonably uniform width along their length were selected for the remineralization process. Their blocks were used for the in situ application device.

As mentioned above, the four blocks from each tooth were distributed as follows: two blocks with lesions for remineralization assessment and two blocks for demineralization inhibition assessment. These blocks were used to fabricate the in situ device as follows. Each block was covered with a polyester blanket (Bard Peripheral Vascular, Inc. Tempe, AZ, USA) and mounted in an orthodontic fixture. The appliance consists of a mesh-lined orthodontic molar pad (American Orthodontics Corp., Sheboygan, USA) with a ring of 0.7 mm orthodontic wire bent so that the ring snugly encircles each trial block. Each device was gamma irradiated prior to delivery to the Subject sterilized.

Carrying out the study

The study was conducted in two different treatment phases, in which the subjects were subjected to one of the following two treatments in a randomised, crossover comparison: (A) Toothpaste containing 10% hydroxyapatite in the form of microclusters (Kinder Karex, Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany and (B) toothpaste containing 500 ppm of fluoride provided as amine fluoride (AMF) (Elmex Kinderzahnpaste, GABA GmbH, Hamburg, Germany) A one-week rinsing phase was followed by a four-week treatment phase consisting of two two-week phases, during which each subject applied his/her assigned treatment under the following conditions: the first two-week phase for the subjects wearing the healthy enamel block in situ device, and the two-week phase for the subjects wearing the enamel block in situ device lesions.

For the one-week rinsing phase, the test persons who met the inclusion criteria were given a specially made rinsing toothpaste that contained neither hydroxyapatite nor fluoride for two minutes of use twice a day (morning and evening).

After the rinsing phase, the test subjects were assigned to either the group using hydroxyapatite or the group using amine fluoride by the coordinator, who assigned random numbers generated by a computer program. However, to ensure that both the testers and the testers were blind to the product, all toothpaste tubes were packaged and coded the same way by the manufacturing/packaging company. After randomization, the four block-bearing in situ appliances derived from one tooth were assigned to one subject. Thereafter, in accordance with accepted principles of orthodontic practice, the first of the four associated appliances was qualified dentist on the buccal surface of the selected lower molar. To secure the appliance, the buccal surface of the selected tooth was gently etched for 30 seconds, washed with water, dried for 30 seconds and isolated using cotton rolls. The underside of the device was coated with Transbond™ XT easy setting adhesive paste (3M Unitek, Monrovia, Ca, USA) and carefully placed. The excess material emerging from the sides was used to mask the sides and the adhesive paste was cured for 20 seconds using an Ortholux XT (3M Unitek, Monrovia, CA, USA). After attaching the device, each subject was given his/her corresponding test toothpaste and a special soft toothbrush. Subjects were instructed to continue their routine of brushing their teeth twice a day for two minutes using only 10 milliliters of water for rinsing. In addition, specific instructions were given for dispensing the toothpaste, and subjects were asked not to brush the device directly, not to eat or drink for at least 30 minutes after brushing, and to use other oral hygiene products (e.g., mouthwash, chewing gum etc.) to waive. As a control, a diary was provided to each subject to record the time of each brushing phase, and the weight of the toothpaste tubes was determined. After two weeks, without using the test toothpaste that morning, the subjects had the device removed and sent to the laboratory for analysis. The device for the second two-week treatment phase was attached. Upon completion of the second two-week treatment phase, subjects were removed from the second device and given a rinse toothpaste and soft-bristled toothbrush, allowing them to undergo a device-less rinse for seven days in preparation for Phase 2 of the study. After completing this flushing phase, the Phase 1 procedure was repeated to complete the second two-week treatment, so that each subject had progressed through both arms of the study.

Post-study procedure and study exit After inter-oral exposure, an approximately 150 µm thick section was cut from each healthy and lesion-containing dental block and processed for microradiography as previously described for baseline control sections. Although the lesion-containing control sections were microradiographed to select appropriate lesions, they were microradiographed again along with post-test sections to quantify Az and LD of the lesions as with the baseline sections. This step allows control and test sections from the same block to be microradiographed and analyzed under the same conditions. For the lesion-containing sections, this process yielded the mineral loss (Az1) and lesion depth (LD1) before the test, the mineral loss (Az2) and lesion depth (LD2) after the test, and the microradiograms for the lesions before and after the test. For the healthy sections, this process yielded the mineral loss (Az) and lesion depth (LD) after the test and the microradiograms before and after the test. Using the microradiographs, the pattern and extent of remineralization in each lesion produced by treatment by each treatment arm was examined by comparing the images before and after the test. For each subject, the post-treatment mineral loss was subtracted from the pre-treatment mineral loss, and then standardized among subjects by dividing this difference by the pre-treatment mineral loss to obtain percent remineralization. The depth of lesions before and after treatment were managed in the same way to obtain the % reduction in lesion depth. The two toothpastes used were compared using these values.

Analysis and calculation of sample size

Sample size calculations were performed using nQuery Advisor software (Statistical Solutions, Cork, Ireland). Based on previous studies in which the mean percent remineralization was 30.3 with a standard deviation of 16.3, and assuming that each of the two toothpaste compositions promotes remineralization and a reduction in lesion depth significantly greater than zero, a effective sample size of 30 subjects has a power of 0.95 with a one-sided 0.05 significance level. Using a two-tailed t-test from two independent means, a difference between a This text was adopted by the DPMA from the original sources. It contains no drawings. Presentation of tables and formulas may be unsatisfactory, stating hypothetical means of zero and a sample mean of remineralization equal to or greater than 10%. However, to provide a 5% dropout, 32 subjects were included.

Statistical analysis

Three endpoints were used to determine mineral loss and lesion depth (1). The mean amount of remineralization and mean amount of lesion depth reduction was determined for the hydroxyapatite toothpaste (Karex) as a percentage of pre-treatment mineral loss and pre-treatment lesion depth, respectively. These percentages were compared to a value of 0, which is the expected value of a toothpaste with no effect. The statistical test used was a one-tailed t-test of a group mean. (2) In the same way, the mean amount of remineralization and the mean amount of lesion depth reduction for the amine fluoride-containing toothpaste (Elmex) were determined and also compared to 0. (3) The primary endpoint was taken using the two-tailed t-test of two independent means to compare the hydroxyapatite toothpaste (Karex) means to the amine fluoride toothpaste (Elmex) means. Equivalence was established when the difference between the two toothpaste compositions was considered clinically irrelevant and A<20% for each measurement method, using the statistical package R, version 3.5.0 for the analysis.

Results

As can also be seen from FIG. 1, two subjects dropped out of the study, one during/after the rinsing phase and one in the first two-week treatment phase while wearing the device. The study 30 subjects (19 female and 11 male) of various ethnic origins with a mean age of 39.5 years completed the study.

The mean rate of remineralization and lesion depth reduction is shown in Table 1 below.

Table 1: Mean rates of remineralization and lesion depth reduction in % for each toothpaste

As can be seen from the table above, each of the toothpastes exhibited greater than 50% remineralization and greater than 25% lesion depth reduction.

For both toothpastes, the mean remineralization and mean reduction in lesion depth was statistically significantly greater than 0. When compared with each other, there was no statistically significant difference in remineralization (p=0.81) or reduction in lesion depth (p=0.68). The 95% confidence interval of the difference between HAP (Karex) and amine fluoride (Elmex) for the mineralization ranged from -8.8% up to 6.5% and the 95% confidence interval of the difference between HAP (Karex) and amine fluoride (Elmex) for lesion depth reduction ranged from -6.8% to 4.1%. Consequently, this study confirms that a HAP-containing toothpaste is not inferior in effectiveness to a fluoride-containing toothpaste.

In the analysis of the healthy tooth blocks evaluated for the ability of the two toothpastes to prevent demineralization of healthy tooth surfaces, there was no evidence of demineralization in any of the tooth blocks after intra-oral exposure to either toothpaste, as shown in Figure 2A & Fig. 2B as can also be seen from Fig. 3A & Fig. 3B. A differentiated comparison of the microradiograms of the lesion-containing samples exposed to the treatment of the toothpastes with HAP (Fig. 4A & Fig. 4B) and amine fluoride (Fig. 5A & Fig. 5B) with the corresponding control microradiograms, the following could be established . While the HAP-containing toothpaste caused more homogeneous remineralization throughout the thickness of the subsurface lesion (Fig. 4B), the remineralization caused by the amine fluoride-containing toothpaste was more dense in the outer half (surface area), so that two areas are clearly visible in Fig. 5B can be seen with different densities. Overall, no incidents of adverse effects were reported by the subjects or clinically noted.

In summary, it can be stated that a HAP-containing toothpaste is on a par with a fluoride-containing toothpaste in terms of remineralization and lesion depth reduction, but without the mentioned negative side effects that can be associated with the use of a fluoride-containing toothpaste.

In addition, unlike a fluoride-containing toothpaste, which prevents demineralization and causes remineralization in the surface area up to about 30 μm, a HAP-containing toothpaste can be used to prevent demineralization and also subsurface areas, such as shown in FIG Fall of about 100 pm to remineralize. This can improve the resistance of the teeth to dental diseases. The abrasiveness of the toothpaste according to Example 1 was then compared with a corresponding toothpaste in which the hydrated silica component (abrasive) was replaced by glycerol (non-abrasive) and which otherwise had the same composition as that of Example 1:

Example 2:

A toothpaste according to the invention was produced, which contains the following components:

Demineralized water 55.30% by weight,

Hydrogenated starch hydrolyzate 21.60% by weight,

Glycerin 2.00% by weight

hydroxyapatite 10.00% by weight,

xylitol 7.00% by weight,

sodium cocoyl glucinate 0.80% by weight,

hexane-1,2-diol 0.40% by weight,

Flavor 0.40% wt.

The toothpaste is a light beige, homogeneous, creamy paste with an average pH of 7.2.

With the toothpastes according to example 1 and according to example 2, the abrasion behavior on polymethyl methacrylate plates was determined as described in “The use of a profilometer for both quantitative and qualitative measurements of toothpaste abrasion”, Int. J.Dent. Hygiene 8, 2010, 237-243.

In the context of this study, it was surprisingly found that the values for the removed volume for the toothpaste according to example 2 are within the standard deviation of those of example 1 and the abrasiveness of both toothpastes is therefore comparable.

With the toothpastes according to example 1 and according to example 2, both the abrasiveness of the dentine and the abrasiveness of the enamel were determined as in “Dental Medicine - Dentifrices - Requirements, test methods and labelling”, EN ISO 11609.

As part of this study, it was surprisingly found that both the RDA values (radioactive dentin abrasion; dentin abrasion) and the REA values (radioactive enamel abrasion; enamel abrasion) of both toothpastes according to Example 2 are within the standard deviation of those of Example 1 and thus the Abrasiveness of both toothpastes on dentine and enamel is comparable.

A comparative study as described in “In vitro removal of stains with dentifrices”, J. Dent. Res. 61, 1982, 1236-1239.

As part of this study, it was surprisingly found that the values for the cleaning performance (pellicle cleaning ratio; PCR) for the toothpaste according to example 2 are within the standard deviation of those of example 1 and the cleaning performance of both toothpastes is therefore comparable.

Example 3:

Four toothpastes were produced with the following recipes:

Recipe 1 :

Demineralized water 55.30% by weight,

Hydrogenated starch hydrolyzate 21.60% by weight,

Glycerin 2.00% by weight

hydroxyapatite 10.00% by weight,

xylitol 7.00% by weight,

cetylpyridinium chloride 0.80% by weight,

hexane-1,2-diol 0.40% by weight,

Flavor 0.40% wt.

The toothpaste is a light beige, homogeneous, creamy paste with average pH of 7.2.

Recipe 2:

Demineralized water 55.30% by weight,

Hydrogenated starch hydrolyzate 21.60% by weight,

Glycerin 2.00% by weight

hydroxyapatite 10.00% by weight,

xylitol 7.00% by weight,

sodium methyl cocoyltaurate 0.80% by weight,

hexane-1,2-diol 0.40% by weight,

Flavor 0.40% wt.

Recipe 3:

Demineralized water 55.30% by weight,

Hydrogenated starch hydrolyzate 21.60% by weight,

Glycerin 2.00% by weight

hydroxyapatite 10.00% by weight,

xylitol 7.00% by weight,

sodium methylglycinate 0.80% by weight,

hexane-1,2-diol 0.40% by weight,

Flavor 0.40% wt.

Recipe 4:

Demineralized water 55.30% by weight,

Hydrogenated starch hydrolyzate 21.60% by weight,

Glycerin 2.00% by weight

hydroxyapatite 10.00% by weight,

xylitol 7.00% by weight, sodium myristoyl sarcosinate 0.80% w/w,

hexane-1,2-diol 0.40% by weight,

Flavor 0.40% wt.

The study enrolled 100 people of various races, ages 18 to 60, who were not taking antibiotics or drugs that affect salivation, who had at least 20 natural, uncapped teeth, and who had a history of dental caries but were beginning to study had no clinically active caries. In addition, the subjects had no dental and/or gum disease, were not pregnant or breastfeeding, and did not smoke tobacco products.

Groups of 25 people each used one of the toothpastes from formulations 1 to 4 at least twice a day for a month. They then assessed the taste, the mouthfeel, the hydroxyapatite distribution during use and the effect on pain sensitivity and foaming behavior. From the evaluation results, the table shown in Fig. 6 was prepared. It shows that taurates, glycinates and sarcosinates achieve significantly better results in terms of taste, mouthfeel, sensitivity to pain and foaming behavior compared to cetylpyridinium chloride.

Claims

36

CLAIMS Dental care product, in particular toothpaste, containing at least one calcium phosphate compound, characterized in that the dental care product is free from fluoride compounds and free from silicon compounds and contains at least one surfactant selected from the group consisting of taurates, glycinates and sarcosinates. Dentifrice according to claim 1, characterized in that the at least one calcium phosphate compound is preferably present in particulate form and is selected from the group consisting of monocalcium phosphate monohydrate (MCPM), monocalcium phosphate anhydrate (MCPA), dicalcium phosphate dihydrate (DCPD, brushite), dicalcium phosphate - Anhydrate (DCPA, monetite), octacalcium phosphate (OCP), a- tricalcium phosphate (a-TCP), ß-tricalcium phosphate (ß-TCP), amorphous calcium phosphate (ACP; also known as CPP-ACP complex = casein phosphopeptide - amorphous calcium phosphate) , amorphous calcium phosphate (ACP), calcium-deficient hydroxyapatite (CDHA), hydroxyapatite (HA or HAP), tetracalcium phosphate (TTCP) and calcium pyrophosphate, particularly preferably from hydroxyapatite and calcium pyrophosphate. Dentifrice according to Claim 1 or Claim 2, characterized in that the dentifrice contains calcium phosphate compounds in an amount of 0.01 to 80% by weight, preferably 0.1 to 20% by weight, particularly preferably 1 to 10% by weight and in particular 1 to 5% by weight, based on the total weight of the dentifrice. Dentifrice according to one of the preceding claims, characterized in that the at least one surfactant is selected from the group consisting of sodium methyl cocoyl taurate, sodium cocoylglycinate, sodium lauroyl sarcosinate and sodium myristoyl sarcosinate. 37

5. Dental care product according to one of the preceding claims, characterized in that the dental care product contains at least one calcium compound selected from the group consisting of calcium carbonate, calcium chloride, calcium bromide, calcium nitrate, calcium acetate, calcium gluconate, calcium lactate, calcium tartrate and their hydrates and mixtures thereof, preferably calcium carbonate.

6. Dentifrice according to one of the preceding claims, characterized in that the dentifrice contains no perlite.

7. Dentifrice according to one of the preceding claims, characterized in that the dentifrice does not contain any aluminum compounds.

8. Dentifrice according to one of the preceding claims, characterized in that the dentifrice does not contain any diamond particles.

9. Dental care product according to one of the preceding claims, characterized in that the dental care product contains no cellulose fibers (microcrystalline cellulose).

10. Dental care product according to one of the preceding claims, characterized in that the dental care product contains no sodium bicarbonate.

11. Dental care product according to one of the preceding claims, characterized in that the dental care product does not contain any glucosides.

12. Dental care product according to one of the preceding claims, characterized in that the dental care product contains no abrasive polymer particles. Dental care product according to one of the preceding claims, characterized in that the dental care product contains no sulfates, in particular no sodium lauryl sulfate, or sulfonates.