EP4236924A4 - Arzneimitteldosierformen zur magenretention - Google Patents

Arzneimitteldosierformen zur magenretention Download PDF

Info

Publication number
EP4236924A4
EP4236924A4 EP21885357.0A EP21885357A EP4236924A4 EP 4236924 A4 EP4236924 A4 EP 4236924A4 EP 21885357 A EP21885357 A EP 21885357A EP 4236924 A4 EP4236924 A4 EP 4236924A4
Authority
EP
European Patent Office
Prior art keywords
dosage forms
drug dosage
gastric retention
gastric
retention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21885357.0A
Other languages
English (en)
French (fr)
Other versions
EP4236924A1 (de
Inventor
Feihuang DENG
Yu Zheng
Xiaoling Li
Senping CHENG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Triastek Inc
Original Assignee
Triastek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triastek Inc filed Critical Triastek Inc
Publication of EP4236924A1 publication Critical patent/EP4236924A1/de
Publication of EP4236924A4 publication Critical patent/EP4236924A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP21885357.0A 2020-10-30 2021-11-01 Arzneimitteldosierformen zur magenretention Pending EP4236924A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2020125333 2020-10-30
PCT/CN2021/127852 WO2022089631A1 (en) 2020-10-30 2021-11-01 Drug dosage forms for stomach retention

Publications (2)

Publication Number Publication Date
EP4236924A1 EP4236924A1 (de) 2023-09-06
EP4236924A4 true EP4236924A4 (de) 2024-10-09

Family

ID=81381894

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21885357.0A Pending EP4236924A4 (de) 2020-10-30 2021-11-01 Arzneimitteldosierformen zur magenretention

Country Status (7)

Country Link
US (1) US20230398066A1 (de)
EP (1) EP4236924A4 (de)
JP (1) JP7858645B2 (de)
KR (1) KR20230098220A (de)
CN (1) CN116456971A (de)
TW (1) TW202233162A (de)
WO (1) WO2022089631A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4512394A3 (de) 2015-06-03 2025-10-22 Triastek, Inc. Darreichungsform und verwendung davon
CA3051614A1 (en) 2017-01-26 2018-08-02 Triastek, Inc. Dosage forms of controlled release at specific gastrointestinal sites
US11571391B2 (en) 2018-01-09 2023-02-07 Triastek, Inc. Oral drug dosage forms compromising a fixed-dose of an ADHD non-stimulant and an ADHD stimulant
US20250360081A1 (en) * 2022-10-18 2025-11-27 Triastek, Inc. Oral drug dosage forms for stomach retention
WO2025124483A1 (en) * 2023-12-13 2025-06-19 Triastek, Inc. Oral drug dosage form for targeted drug delivery based on tracking marker and methods of design and use thereof
TW202600188A (zh) * 2024-03-15 2026-01-01 大陸商南京三迭紀醫藥科技有限公司 用於體內滯留的藥物劑型

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038650A1 (en) * 1998-12-23 2000-07-06 Alza Corporation Gastric retention dosage form having multiple layers
CA2412671A1 (en) * 2000-06-20 2001-12-27 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US20130149379A1 (en) * 2001-10-25 2013-06-13 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735804A (en) * 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
JPS6226215A (ja) * 1985-05-10 1987-02-04 メルク　エンド　カムパニ−　インコ−ポレ−テツド 一定に制御した時間内胃中に保持できる薬剤移送装置
JPH0624959A (ja) * 1991-10-04 1994-02-01 Bayer Yakuhin Kk 胃内浮遊型薬物徐放性固形製剤
US6797283B1 (en) * 1998-12-23 2004-09-28 Alza Corporation Gastric retention dosage form having multiple layers
GB0214013D0 (en) * 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
TWI336260B (en) * 2002-07-25 2011-01-21 Glaxo Group Ltd Dosage form suitable for retaining drug substance
PE20080907A1 (es) * 2006-08-31 2008-08-22 Novartis Ag Sistema de suministro de farmaco oral gastro-retentivo de liberacion extendida para valsartan
CA2949372C (en) * 2014-06-02 2023-08-22 Teva Pharmaceutical Industries Ltd. Expandable gastroretentive dosage form
RU2766335C2 (ru) * 2014-06-11 2022-03-15 Массачусетс Инститьют Оф Текнолоджи Удерживаемые структуры и связанные способы
CN107847398B (zh) * 2016-05-05 2019-05-07 南京三迭纪医药科技有限公司 控制释放的药物剂型
CA3051614A1 (en) * 2017-01-26 2018-08-02 Triastek, Inc. Dosage forms of controlled release at specific gastrointestinal sites
US10350822B1 (en) * 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038650A1 (en) * 1998-12-23 2000-07-06 Alza Corporation Gastric retention dosage form having multiple layers
CA2412671A1 (en) * 2000-06-20 2001-12-27 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US20130149379A1 (en) * 2001-10-25 2013-06-13 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KLAUSNER E A ET AL: "Expandable gastroretentive dosage forms", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 90, no. 2, 24 June 2003 (2003-06-24), pages 143 - 162, XP004431308, ISSN: 0168-3659, DOI: 10.1016/S0168-3659(03)00203-7 *
See also references of WO2022089631A1 *

Also Published As

Publication number Publication date
EP4236924A1 (de) 2023-09-06
CN116456971A (zh) 2023-07-18
KR20230098220A (ko) 2023-07-03
TW202233162A (zh) 2022-09-01
JP2023548216A (ja) 2023-11-15
US20230398066A1 (en) 2023-12-14
JP7858645B2 (ja) 2026-05-14
WO2022089631A1 (en) 2022-05-05

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A4 Supplementary search report drawn up and despatched

Effective date: 20240911

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/20 20060101ALI20240905BHEP

Ipc: A61K 9/00 20060101ALI20240905BHEP

Ipc: A61K 9/24 20060101ALI20240905BHEP

Ipc: A61K 9/22 20060101AFI20240905BHEP