EP4218802A3 - Conjugates for targeted cell surface editing - Google Patents

Conjugates for targeted cell surface editing Download PDF

Info

Publication number
EP4218802A3
EP4218802A3 EP23155976.6A EP23155976A EP4218802A3 EP 4218802 A3 EP4218802 A3 EP 4218802A3 EP 23155976 A EP23155976 A EP 23155976A EP 4218802 A3 EP4218802 A3 EP 4218802A3
Authority
EP
European Patent Office
Prior art keywords
conjugates
cell surface
targeted cell
surface editing
editing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23155976.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4218802A2 (en
Inventor
Melissa Gray
Elliot C. Woods
Han XIAO
Carolyn R. Bertozzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of EP4218802A2 publication Critical patent/EP4218802A2/en
Publication of EP4218802A3 publication Critical patent/EP4218802A3/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6815—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
EP23155976.6A 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing Pending EP4218802A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662357645P 2016-07-01 2016-07-01
PCT/US2017/040411 WO2018006034A1 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing
EP17821402.9A EP3478314B1 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP17821402.9A Division EP3478314B1 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing
EP17821402.9A Division-Into EP3478314B1 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing

Publications (2)

Publication Number Publication Date
EP4218802A2 EP4218802A2 (en) 2023-08-02
EP4218802A3 true EP4218802A3 (en) 2023-09-27

Family

ID=60787043

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23155976.6A Pending EP4218802A3 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing
EP17821402.9A Active EP3478314B1 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17821402.9A Active EP3478314B1 (en) 2016-07-01 2017-06-30 Conjugates for targeted cell surface editing

Country Status (14)

Country Link
US (2) US11459398B2 (hr)
EP (2) EP4218802A3 (hr)
JP (1) JP7187024B2 (hr)
KR (2) KR102581747B1 (hr)
CN (1) CN109641038A (hr)
AU (2) AU2017290554B2 (hr)
BR (1) BR112018077362A2 (hr)
CA (1) CA3027234A1 (hr)
DK (1) DK3478314T3 (hr)
ES (1) ES2947312T3 (hr)
IL (2) IL263617B2 (hr)
MX (1) MX2018016393A (hr)
SG (1) SG11201811719RA (hr)
WO (1) WO2018006034A1 (hr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3341411A1 (en) 2015-08-28 2018-07-04 Alector LLC Anti-siglec-7 antibodies and methods of use thereof
GB201616006D0 (en) * 2016-09-20 2016-11-02 Univ Court Of The Univ Of St Andrews The Cell modulation
WO2018231661A1 (en) * 2017-06-12 2018-12-20 Tianxin Wang Methods and reagents to treat tumor and cancer
CA3087529A1 (en) 2018-01-03 2019-07-11 Palleon Pharmaceuticals Inc. Recombinant human sialidases, sialidase fusion proteins, and methods of using the same
CA3100626A1 (en) * 2018-06-08 2019-12-12 Alector Llc Anti-siglec-7 antibodies and methods of use thereof
GB201811291D0 (en) * 2018-07-10 2018-08-29 Univ Dublin City A method of predicting response to treatment in cancer patients
EP3604551A1 (en) * 2018-07-31 2020-02-05 Université de Bretagne Occidentale Complement-dependent cytotoxicity and sialylation as biomarkers for predicting clinical response to cancer treatment with antibody or derivative mediating complement activation
GB201819920D0 (en) * 2018-12-06 2019-01-23 Pneumagen Ltd Cancer treatment
WO2020142727A1 (en) * 2019-01-03 2020-07-09 Palleon Pharmaceuticals Inc. Methods and compositions for treating cancer with immune cells
WO2020172072A1 (en) * 2019-02-21 2020-08-27 The General Hospital Corporation Glycoengineering immunoglobulin e
WO2021003469A2 (en) * 2019-07-03 2021-01-07 Palleon Pharmaceuticals Inc. Recombinant human sialidases, sialidase fusion proteins, and methods of using the same
WO2021003464A1 (en) * 2019-07-03 2021-01-07 Palleon Pharmaceuticals Inc. Sialidase-pd-l1-antibody fusion proteins and methods of use thereof
CA3145772A1 (en) * 2019-07-03 2021-01-07 Palleon Pharmaceuticals Inc. Recombinant sialidases and methods of using the same
US20220387616A1 (en) * 2019-07-03 2022-12-08 Palleon Pharmaceuticals Inc. Sialidase-her2-antibody fusion proteins and methods of use thereof
US20220380742A1 (en) * 2019-07-03 2022-12-01 Palleon Pharmaceuticals Inc. Sialidase-cd20-antibody fusion proteins and methods of use thereof
CA3191901A1 (en) * 2020-07-21 2022-01-27 The Scripps Research Institute Disruption of cd28-sialoside ligand complexes to enhance t cell activation
EP4255447A1 (en) * 2020-12-04 2023-10-11 Dyne Therapeutics, Inc. Antibody-oligonucleotide complexes and uses thereof
KR20240028335A (ko) 2021-04-23 2024-03-05 간엔에이 바이오, 인크. 글리칸 변형 핵산, 제조 방법 및 치료 용도
WO2023129822A2 (en) * 2021-12-28 2023-07-06 The Board Of Trustees Of The Leland Stanford Junior University Chemically modified bacterial peptidoglycan compositions and uses thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2620649C3 (de) 1976-05-11 1980-11-06 Behringwerke Ag, 3550 Marburg Immunologisches Adjuvans
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
FR2828386B1 (fr) 2001-08-10 2004-06-11 Jean Noel Acquaviva Ecran de vision coupe-vent
US7807174B2 (en) 2002-11-22 2010-10-05 Nexbio, Inc. Class of therapeutic protein based molecules
US8512710B2 (en) 2002-11-22 2013-08-20 Ansun Biopharma, Inc. Class of therapeutic protein based molecules
CN101804200A (zh) 2002-11-22 2010-08-18 余芒 广谱抗病毒的治疗和预防
JP5457680B2 (ja) 2006-01-24 2014-04-02 アンサン バイオファーマ，インコーポレイテッド 高分子マイクロスフェアの調製技術
EP2389946A1 (en) 2006-03-23 2011-11-30 Novartis AG Anti-tumor cell antigen antibody therapeutics
EP1938835A1 (en) 2006-12-29 2008-07-02 Pevion Biotech AG Non-specific immunostimulating agents
EP2496251A4 (en) 2009-11-06 2013-10-30 Nexbio Inc METHODS, COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF THE RESPIRATORY TRACT
AU2013274078A1 (en) * 2012-06-14 2015-01-29 Ambrx, Inc. Anti-PSMA antibodies conjugated to nuclear receptor ligand polypeptides
CN112587671A (zh) * 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
UA105278C2 (ru) * 2012-09-06 2014-04-25 Інститут Біології Клітини Нан України Способ получения каталитически активных антител (абзимов) с сиалидазной активностью
EP2970857A4 (en) 2013-03-15 2016-11-02 Ansun Biopharma Inc NEW PROTEIN PURIFICATION PROCESS
WO2014201034A2 (en) 2013-06-10 2014-12-18 Ansun Biopharma, Inc. Treatment for polyomavirus infection
WO2014201027A2 (en) 2013-06-10 2014-12-18 Ansun Biopharma, Inc. Treatment of merkel cell polyomavirus infection
US20170165334A1 (en) 2015-12-11 2017-06-15 Tianxin Wang Methods to Treat Diseases with Protein, Peptide, Antigen Modification and Hemopurification
US20170119859A1 (en) 2014-05-30 2017-05-04 Ansun Biopharma, Inc. Treatment of middle east respiratory syndrome coronavirus
US20170306014A1 (en) 2014-09-10 2017-10-26 Innate Pharma Cross reactive siglec antibodies
WO2016044656A1 (en) 2014-09-17 2016-03-24 Ansun Biopharma, Inc. Treatment of infection by human enterovirus d68
WO2016200916A1 (en) 2015-06-08 2016-12-15 Ansun Biopharma, Inc. Treatment of human metapneumovirus
AR107483A1 (es) 2016-01-29 2018-05-02 Hanmi Pharm Ind Co Ltd Conjugado de enzimas terapéuticas
US20180271997A1 (en) 2016-05-31 2018-09-27 Tianxin Wang Methods and Reagents to Treat Tumor and Cancer
GB201616006D0 (en) 2016-09-20 2016-11-02 Univ Court Of The Univ Of St Andrews The Cell modulation
BR112019013202A2 (pt) 2016-12-28 2019-12-10 Japan Chem Res formulação liofilizada
WO2018231661A1 (en) 2017-06-12 2018-12-20 Tianxin Wang Methods and reagents to treat tumor and cancer
WO2020018996A2 (en) 2018-07-20 2020-01-23 Ansun Biopharma, Inc. Delivery of sialidase to cancer cells, immune cells and the tumor microenvironment

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DAVID RABUKA ET AL: "Site-specific chemical protein conjugation using genetically encoded aldehyde tags", NATURE PROTOCOLS, vol. 7, no. 6, 10 May 2012 (2012-05-10), pages 1052 - 1067, XP055193459, ISSN: 1754-2189, DOI: 10.1038/nprot.2012.045 *
GRAY MELISSA A ET AL: "Targeted glycan degradation potentiates the anticancer immune response in vivo", NATURE CHEMICAL BIOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 16, no. 12, 17 August 2020 (2020-08-17), pages 1376 - 1384, XP037295456, ISSN: 1552-4450, [retrieved on 20200817], DOI: 10.1038/S41589-020-0622-X *
HAN XIAO ET AL: "Precision glycocalyx editing as a strategy for cancer immunotherapy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 113, no. 37, 22 August 2016 (2016-08-22), pages 10304 - 10309, XP055662294 *
TSENG HUI-CHUN ET AL: "Desialylation of human cancer cells leading apoptosis by treatment with purified and overexpressed nanI cloned from Clostridium perfringens ATCC 10543", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 41, no. 1-2, 10 May 2007 (2007-05-10), pages 5 - 12, XP022069874, ISSN: 0141-0229, DOI: 10.1016/J.ENZMICTEC.2006.11.020 *
VAN ROOIJEN N ET AL: "Monoclonal antibody mediated targeting of enzymes - A comparative study using the mouse spleen as a model system", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 151, no. 1-2, 6 July 1992 (1992-07-06), pages 149 - 155, XP023657583, ISSN: 0022-1759, [retrieved on 19920706], DOI: 10.1016/0022-1759(92)90113-8 *

Also Published As

Publication number Publication date
ES2947312T3 (es) 2023-08-04
US11459398B2 (en) 2022-10-04
MX2018016393A (es) 2019-08-12
US20230287140A1 (en) 2023-09-14
JP2022176981A (ja) 2022-11-30
IL305907A (en) 2023-11-01
IL263617B2 (en) 2024-02-01
KR102581747B1 (ko) 2023-09-22
CN109641038A (zh) 2019-04-16
AU2017290554B2 (en) 2020-10-08
BR112018077362A2 (pt) 2019-10-01
SG11201811719RA (en) 2019-01-30
US20190248919A1 (en) 2019-08-15
AU2020289739A1 (en) 2021-01-21
AU2017290554A1 (en) 2019-01-17
EP3478314B1 (en) 2023-03-22
WO2018006034A1 (en) 2018-01-04
EP3478314A4 (en) 2020-05-27
EP3478314A1 (en) 2019-05-08
CA3027234A1 (en) 2018-01-04
KR20190025925A (ko) 2019-03-12
IL263617A (en) 2019-02-03
NZ749410A (en) 2021-01-29
EP4218802A2 (en) 2023-08-02
IL263617B1 (en) 2023-10-01
JP7187024B2 (ja) 2022-12-12
DK3478314T3 (da) 2023-06-19
JP2019531697A (ja) 2019-11-07
KR20230142631A (ko) 2023-10-11

Similar Documents

Publication Publication Date Title
EP4218802A3 (en) Conjugates for targeted cell surface editing
AU2018320870A1 (en) RNA targeting methods and compositions
MX2021007376A (es) Moléculas bifuncionales para el direccionamiento lisosómico y composiciones y métodos relacionados.
WO2018191278A3 (en) Targeted compositions
AU2018236742B2 (en) Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
NZ747138A (en) Targeted nucleic acid conjugate compositions
MX2017010746A (es) Composicion y metodos para la expresion regulada de un complejo de arn guia/endonucleasa cas.
WO2018109170A3 (en) Il-11ra antibodies
WO2019090148A3 (en) Compositions and methods related to therapeutic cell systems for tumor growth inhibition
WO2018109174A3 (en) Il-11 antibodies
WO2019089884A3 (en) Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy
MX2018009085A (es) Conjugados de anticuerpos anti-cd74, composiciones que comprenden conjugados de anticuerpos anti-cd74 y metodos de uso de congujados de anticuerpos anti-cd74.
CR11427A (es) 2-fluoro-2 - desoxitetrahidrouridinas como inhibidores de citidina desaminasa
EA029818B8 (ru) Цитотоксические и антимитотические соединения и способы их применения
BR112019000693A2 (pt) composições de muc1- car e métodos para uso
MX2021014663A (es) Il-23a y tnf-alfa orientados y compuesto y sus usos.
MX2022010515A (es) Conjugacion mediada por transglutaminasa.
MX2017003476A (es) Compuestos citotoxicos y anti-mitoticos, y metodos para usar los mismos.
WO2012075117A3 (en) Small molecule-polymer conjugates and methods of making same
WO2016164743A3 (en) Cd38 ligand-drug conjugates for targeted cancer therapy
GB2568181A (en) Wheat
AU2018337947A1 (en) Compositions and methods for predicting response to NaPi2b-targeted therapy
WO2019092618A3 (en) Glp-1 receptor ligand moiety conjugated oligonucleotides and uses thereof
EP3663397A4 (en) NEW PSICOSE-6-PHOSPHATE-PHOSPHATASE, COMPOSITION FOR THE MANUFACTURING OF PSICOSE INCLUDING THIS ENZYME, PROCESS FOR MANUFACTURING PSICOSE USING THIS ENZYME
SA518390788B1 (ar) مركب يستهدف إنترلوكين- 23 أ وعامل تنشيط الخلايا البائية واستخداماته

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 3478314

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 47/68 20170101ALI20230824BHEP

Ipc: A61K 39/395 20060101ALI20230824BHEP

Ipc: C07K 14/47 20060101ALI20230824BHEP

Ipc: A61K 39/00 20060101AFI20230824BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240327

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR