EP4172237A1 - Procédé d'alcoxylation amélioré - Google Patents
Procédé d'alcoxylation amélioréInfo
- Publication number
- EP4172237A1 EP4172237A1 EP21746073.2A EP21746073A EP4172237A1 EP 4172237 A1 EP4172237 A1 EP 4172237A1 EP 21746073 A EP21746073 A EP 21746073A EP 4172237 A1 EP4172237 A1 EP 4172237A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- acid
- formula
- compound
- fatty
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 54
- 230000008569 process Effects 0.000 title claims description 39
- 239000002253 acid Substances 0.000 claims abstract description 88
- 239000012429 reaction media Substances 0.000 claims abstract description 31
- 150000001875 compounds Chemical class 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 37
- 239000003054 catalyst Substances 0.000 claims description 28
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 21
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 20
- 150000007513 acids Chemical class 0.000 claims description 18
- -1 alkylpolyglycosides Chemical class 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 125000002947 alkylene group Chemical group 0.000 claims description 12
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- KLDXJTOLSGUMSJ-UNTFVMJOSA-N (3s,3ar,6s,6ar)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol Chemical compound O[C@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-UNTFVMJOSA-N 0.000 claims description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
- 239000000194 fatty acid Substances 0.000 claims description 8
- 229930195729 fatty acid Natural products 0.000 claims description 8
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 7
- 229940098779 methanesulfonic acid Drugs 0.000 claims description 7
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 235000021355 Stearic acid Nutrition 0.000 claims description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 6
- 150000002430 hydrocarbons Chemical group 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
- 229920005862 polyol Polymers 0.000 claims description 5
- 150000003077 polyols Chemical class 0.000 claims description 5
- 238000011084 recovery Methods 0.000 claims description 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 4
- 239000007848 Bronsted acid Substances 0.000 claims description 4
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 claims description 4
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical class CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims description 4
- 229960002479 isosorbide Drugs 0.000 claims description 4
- ZWRUINPWMLAQRD-UHFFFAOYSA-N nonan-1-ol Chemical class CCCCCCCCCO ZWRUINPWMLAQRD-UHFFFAOYSA-N 0.000 claims description 4
- 150000002989 phenols Chemical class 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims description 4
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 claims description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 3
- 235000013824 polyphenols Nutrition 0.000 claims description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 2
- JOLVYUIAMRUBRK-UHFFFAOYSA-N 11',12',14',15'-Tetradehydro(Z,Z-)-3-(8-Pentadecenyl)phenol Natural products OC1=CC=CC(CCCCCCCC=CCC=CCC=C)=C1 JOLVYUIAMRUBRK-UHFFFAOYSA-N 0.000 claims description 2
- YLKVIMNNMLKUGJ-UHFFFAOYSA-N 3-Delta8-pentadecenylphenol Natural products CCCCCCC=CCCCCCCCC1=CC=CC(O)=C1 YLKVIMNNMLKUGJ-UHFFFAOYSA-N 0.000 claims description 2
- 235000021357 Behenic acid Nutrition 0.000 claims description 2
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 claims description 2
- JOLVYUIAMRUBRK-UTOQUPLUSA-N Cardanol Chemical compound OC1=CC=CC(CCCCCCC\C=C/C\C=C/CC=C)=C1 JOLVYUIAMRUBRK-UTOQUPLUSA-N 0.000 claims description 2
- FAYVLNWNMNHXGA-UHFFFAOYSA-N Cardanoldiene Natural products CCCC=CCC=CCCCCCCCC1=CC=CC(O)=C1 FAYVLNWNMNHXGA-UHFFFAOYSA-N 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims description 2
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000002841 Lewis acid Substances 0.000 claims description 2
- 239000004435 Oxo alcohol Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 2
- 229940114079 arachidonic acid Drugs 0.000 claims description 2
- 235000021342 arachidonic acid Nutrition 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 229940116226 behenic acid Drugs 0.000 claims description 2
- QDHFHIQKOVNCNC-UHFFFAOYSA-N butane-1-sulfonic acid Chemical compound CCCCS(O)(=O)=O QDHFHIQKOVNCNC-UHFFFAOYSA-N 0.000 claims description 2
- BRXCDHOLJPJLLT-UHFFFAOYSA-N butane-2-sulfonic acid Chemical compound CCC(C)S(O)(=O)=O BRXCDHOLJPJLLT-UHFFFAOYSA-N 0.000 claims description 2
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims description 2
- PTFIPECGHSYQNR-UHFFFAOYSA-N cardanol Natural products CCCCCCCCCCCCCCCC1=CC=CC(O)=C1 PTFIPECGHSYQNR-UHFFFAOYSA-N 0.000 claims description 2
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 claims description 2
- 150000002028 dodecanols Chemical class 0.000 claims description 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 150000007517 lewis acids Chemical class 0.000 claims description 2
- 229930013686 lignan Natural products 0.000 claims description 2
- 150000005692 lignans Chemical class 0.000 claims description 2
- 235000009408 lignans Nutrition 0.000 claims description 2
- 229920005610 lignin Polymers 0.000 claims description 2
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims description 2
- 229930014626 natural product Natural products 0.000 claims description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 2
- 229940055577 oleyl alcohol Drugs 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 claims description 2
- 239000001593 sorbitan monooleate Substances 0.000 claims description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 2
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 2
- 239000001587 sorbitan monostearate Substances 0.000 claims description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 claims description 2
- 229940035048 sorbitan monostearate Drugs 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 150000008163 sugars Chemical class 0.000 claims description 2
- 229920001864 tannin Polymers 0.000 claims description 2
- 239000001648 tannin Substances 0.000 claims description 2
- 235000018553 tannin Nutrition 0.000 claims description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 2
- JSPLKZUTYZBBKA-UHFFFAOYSA-N trioxidane Chemical compound OOO JSPLKZUTYZBBKA-UHFFFAOYSA-N 0.000 claims description 2
- 229960002703 undecylenic acid Drugs 0.000 claims description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 2
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-UHFFFAOYSA-N 9,12-Octadecadienoic Acid Chemical compound CCCCCC=CCC=CCCCCCCCC(O)=O OYHQOLUKZRVURQ-UHFFFAOYSA-N 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 claims 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 1
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 1
- 229940049964 oleate Drugs 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 claims 1
- 239000012535 impurity Substances 0.000 description 26
- 238000009472 formulation Methods 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 13
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 10
- 150000002170 ethers Chemical class 0.000 description 10
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 9
- 238000003786 synthesis reaction Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 238000003379 elimination reaction Methods 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000008030 elimination Effects 0.000 description 6
- 238000010306 acid treatment Methods 0.000 description 5
- 150000001299 aldehydes Chemical class 0.000 description 5
- 235000019253 formic acid Nutrition 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000019645 odor Nutrition 0.000 description 5
- 239000008117 stearic acid Substances 0.000 description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
- 238000006555 catalytic reaction Methods 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 150000001241 acetals Chemical class 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 150000002373 hemiacetals Chemical class 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 2
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- KVVSCMOUFCNCGX-UHFFFAOYSA-N cardol Chemical compound CCCCCCCCCCCCCCCC1=CC(O)=CC(O)=C1 KVVSCMOUFCNCGX-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000007046 ethoxylation reaction Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000003337 fertilizer Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000009533 lab test Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 239000000565 sealant Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 description 2
- LEAQUNCACNBDEV-KHPPLWFESA-N (Z)-undec-1-en-1-ol Chemical compound CCCCCCCCC\C=C/O LEAQUNCACNBDEV-KHPPLWFESA-N 0.000 description 1
- 239000005968 1-Decanol Substances 0.000 description 1
- XCJGLBWDZKLQCY-UHFFFAOYSA-N 2-methylpropane-2-sulfonic acid Chemical compound CC(C)(C)S(O)(=O)=O XCJGLBWDZKLQCY-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- UFMJCOLGRWKUKO-UHFFFAOYSA-N cardol diene Natural products CCCC=CCC=CCCCCCCCC1=CC(O)=CC(O)=C1 UFMJCOLGRWKUKO-UHFFFAOYSA-N 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000005188 flotation Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000003165 hydrotropic effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/08—Saturated oxiranes
- C08G65/10—Saturated oxiranes characterised by the catalysts used
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2615—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen the other compounds containing carboxylic acid, ester or anhydride groups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/02—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the alkali- or alkaline earth metals or beryllium
- B01J23/04—Alkali metals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
- C08K5/41—Compounds containing sulfur bound to oxygen
- C08K5/42—Sulfonic acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics
Definitions
- the present invention relates to an improved alkoxylation process, more particularly a process for preparing alkoxylated compounds, in particular alkoxylated compounds of high molar masses, and more particularly alkoxylated compounds of high molar masses and comprising a fatty chain.
- alkoxylated compounds also called alkoxylates in the remainder of the description
- fatty chain alkoxylates are compounds which are increasingly used in particular as additives, adjuvants, chemical intermediates, surfactants.
- active agents nonionic surfactants
- others in various fields of application, such as for example in the chemical industry in general, in the pharmaceutical industry, cosmetics, food industry, phytosanitary, textile, in the industry of cleaning, ores, fertilizers, oil and gas extraction, road construction, coatings, adhesives, sealants, lubrication, paper, and others, to name just the main areas of application .
- the alkoxylated compounds must generally and most often have high purities, that is to say contain quantities as low as possible of impurities, and in particular of undesirable products, and more particularly those generated during the synthesis of said alkoxylated compounds.
- alkoxylated compounds in particular high molecular alkoxylates, and more particularly high molecular alkoxylates comprising a fatty chain, often remains difficult to carry out and in particular when it is desired to obtain products exhibiting a high purity, that is to say with the lowest possible quantities of by-products, with good manufacturing yields.
- This patent further indicates that the elimination of unpleasant odors is carried out by neutralization of the product of the propoxylation reaction with an acid of pK a less than 5, at a temperature between 80 ° C and 130 ° C then by brought into contact with water, at a temperature between 80 ° C and 130 ° C.
- the recovery of the final product, without bad odors, comprises the elimination of water and a stripping of the formed propionaldehyde or its derivatives.
- alkoxylated compounds in particular of alkoxylated compounds of high molar masses, and more particularly of alkoxylated compounds of high molar masses and comprising a fatty chain meeting the purity criteria of more and more severe imposed by industries which use such molecules, in particular as nonionic surfactants, synthetic intermediates and others, as indicated above.
- Another objective is to provide a process for the synthesis of alkoxylated compounds, in particular of alkoxylated compounds of high molar masses, and more particularly of alkoxylated compounds of high molar masses and comprising a fatty chain which can be easily industrialized and advantageously which can be used. easily adapted to the techniques and installations already existing and used for the synthesis of such compounds. It has now been discovered that the aforementioned objectives can be achieved, in whole or at least in part, by virtue of the present invention which will be described in more detail in the description which follows.
- the present invention relates to the process for preparing compounds of formula (1):
- - R represents a fatty hydrocarbon chain comprising from 8 to 60 carbon atoms, linear or branched, optionally comprising one or more saturated or unsaturated rings, and possibly comprising one or more oxygen atoms,
- - Ak represents an alkylene unit with 2, 3 or 4 carbon atoms, preferably with 2 or 3 carbon atoms, and
- - n is an integer between 10 and 250, preferably between 15 and 200, more preferably between 18 and 160, limits included, said process comprising at least the following steps: a) reaction of a compound of formula R-OH with at least one alkylene oxide, in presence of a catalyst, b) treatment of the reaction medium with an acid whose pK a is less than or equal to 3.5, and c) recovery of the compound of formula R- (Ak-0-) n H by treatment of the medium reaction thus neutralized.
- fatty chain R present in the compound of formula (1) and the compound of formula R-OH
- a hydrocarbon chain comprising from 8 to 60 carbon atoms , preferably 8 to 40 carbon atoms, more preferably 10 to 30 carbon atoms, limits included.
- This fatty chain R can comprise one or more rings, saturated or partially or totally unsaturated, said chain can also be saturated or comprise one or more unsaturations, most often in the form of double (s) bond (s), triple (s) ) bond (s), or combinations of these unsaturations.
- This fatty chain may be linear or branched and may contain one or more oxygen atoms, for example in the form of ether, alcohol, acid, ester functions, as well as the combinations of two or more of these oxygen-bearing functions, to name only the most common functions carrying at least one oxygen atom.
- the polyalkoxylated chains are not considered to be fatty chains within the meaning of the present invention, but the R fatty chains within the meaning of the invention can themselves comprise one or more polyalkoxylated chains.
- the compound of formula R-OH can be of any type well known to those skilled in the art and in particular can be chosen from fatty alcohols, fatty acids, poly fatty acids , alcohol-esters, sugar esters, glycerides (mainly mono- and di-fatty esters), fatty-chain phenol derivatives, but also polyols, such as sugars, alkylpolyglycosides, polyphenols, as well as mixtures of two or more of them, in all proportions. It is very particularly preferred to carry out the process from compounds of formula R-OH chosen from fatty alcohols, fatty acids, poly fatty acids, fatty-chain phenol derivatives, polyphenols, as well as mixtures of two or more. several of them, in all proportions and more preferably among fatty alcohols, fatty acids and fatty-chain phenol derivatives, as well as mixtures of two or more of them, in all proportions.
- octanoic acid or caprylic
- acid nonanoic or pelargonic
- decanoic or capric
- undecanoic or undecylenic
- dodecanoic or lauric
- tetradecanoic or myristic
- hexadecanoic or palmitic
- octadecanoic or stearic
- 9-octadecenoic or oleic
- 9,12 -octadecadienoic or linoleic
- 9,12,15-octadecatrienoic or linolenic
- the alkylene oxide used in the process of the present invention can be of any type well known to those skilled in the art, and is advantageously chosen from ethylene oxide, propylene oxide and oxide of butylene, as well as their mixtures in all proportions, preferably from ethylene oxide and propylene oxide, as well as their mixtures in all proportions, more preferably the alkylene oxide is ethylene oxide or propylene oxide, advantageously the alkylene oxide is ethylene oxide.
- the number "n” of units (Ak-O-) present in the compound of formula (1) is between 10 and 250, preferably between 15 and 200, more preferably between 18 and 160, limits included, as indicated previously. In a very particularly preferred embodiment, the number “n” of units (Ak-O-) present in the compound of formula (1) is between 20 and 150, better still between 20 and 140, typically between 30 and 140. , more specifically between 40 and 130, for example between 50 and 100, or alternatively between 50 and 70, limits included. It must be understood that when several different alkylene oxides make up the (Ak-0-) n chain, they can be arranged in a random manner ("random"), alternately or in blocks, as well as all the combinations. of these various arrangements.
- the nature and the amount of catalyst used for the alkoxylation reaction can also vary widely, depending on the alkoxylation techniques well known to those skilled in the art.
- the catalyst is generally a basic or alkaline catalyst, such as for example sodium hydroxide (NaOH) or potassium hydroxide (KOH). This is referred to as soda or potash catalysis, respectively.
- catalysts can also be used and in particular those now known to those skilled in the art specializing in alkoxylation under the name of “narrow range” catalysts, and are for example chosen from among calcium-based catalysts, based on derivatives containing boron (for example of BF 3 type and derivatives), catalysts of hydrotalcites type, and catalysts of dimetallic cyanide type (“DiMetallic Cyanide” in English, or DMC).
- DMC dimetallic Cyanide
- DMC catalysts are for example described in patents US6429342, US6977236 and PL398518.
- the catalysts known and commercially available include zinc hexacyanocobaltate with one or more ligands, such as Arcol Catalyst ® marketed by the Company or Covestro MOE-DMC catalyst ® marketed by the company Mexeo.
- the amount of catalyst used for the alkoxylation reaction ranges from 1 ppm to 10000 ppm (weight) relative to the amount of compound of formula R-OH, of preferably from 10 ppm to 10,000 ppm (weight).
- the process implements a basic catalysis and the catalyst used is a basic or alkaline catalyst, advantageously sodium hydroxide (NaOH) or potassium hydroxide (KOH ), or alternatively sodium or potassium alcoholates, more advantageously sodium hydroxide or potassium hydroxide, most often potassium hydroxide.
- an acid generally a weak organic acid, for example chosen from acid formic acid, acetic acid and lactic acid, according to conventional techniques and well known to those skilled in the art.
- the treatment with an acid of pK a less than or equal to 3.5 has been shown to be particularly effective on the impurities generated during the preparation of compounds of formula (1), in particular ethoxylated or else ethoxylated and propoxylated.
- the acids of pK a less than or equal to 3.5 which can be used during step b) of the process of the present invention can be of any type known per se, acids organic or mineral, Bronsted acids or Lewis acids. However, it is preferred to use Bronsted acids, proton donor acids, having a pK a less than or equal to 3.5, preferably less than or equal to 3, more preferably less than or equal to 2.5, more preferably less or less. equal to 2, that is to say the strong proton-donating acids, also called labile hydrogen.
- acids very particularly suitable for the process of the present invention mention may be made without limitation of hydrochloric, sulfuric, nitric and phosphoric acids, but also sulfamic acid, para-toluenesulfonic acid, alkane acids -sulphonics, as well as mixtures of two or more of them in all proportions.
- acids whose pK a is greater than 3.5 do not allow satisfactory chemical transformation of the unsaturated ether type impurities generated during the preparation of fatty chain alkoxylates of high molecular weight, in particularly ethoxylation or ethoxylation / propoxylation products of fatty chain and high molecular weight compounds.
- high molecular weight is meant within the meaning of the present a molecular weight, as measured by gel permeation chromatography (GPC) generally between 500 g mol 1 and 20,000 g mol 1 , preferably between 750 g mol 1 and 15,000 g mol 1 , better still between 1000 g mol 1 and 15000 g mol 1 , more particularly between 1000 g mol 1 and 10,000 g mol 1 .
- GPC gel permeation chromatography
- the process of the present invention further comprises a step a2) between step a) and step b), said step a2) co-occurring adding an acid to the crude reaction medium resulting from step a).
- the acid used for step a2) can be any type of acid well known to those skilled in the art, strong or weak, organic or menial, or the acid used in step b) as will be explained. below.
- step b) of optionally neutralized reaction treatment of the process according to the present invention it is preferred to use acids with pK a less than or equal to 3.5 which are perfectly miscible in the reaction medium, that is, that is to say poorly, or even not able, to form a separate phase in the reaction medium.
- the preferred acids of pK a less than or equal to 3.5 are those whose environmental impact is as low as possible.
- alkanesulphonic acid is understood to mean preferably the alkanesulfonic acids of formula R a -S0 3 H, where R a represents a saturated, linear or branched hydrocarbon chain comprising from 1 to 4 carbon atoms.
- the preferred alkanesulphonic acids for use in the context of the present invention are chosen from methanesulphonic acid, ethanesulphonic acid, n-propanesulphonic acid, / so acid -propanesulphonic acid, n-butanesulphonic acid, / so-butanesulphonic acid, sec-butanesulphonic acid, tert-butanesulphonic acid, and mixtures of two or more d 'between them in all proportions.
- the alkanesulphonic acid used in the context of the present invention is methanesulphonic acid or ethanesulphonic acid, most preferably the acid used is methanesulfonic acid.
- the process according to the present invention implements, in step b) of treatment of the reaction medium, at least one alkanesulphonic acid chosen from linear or branched chain alkanesulphonic acids comprising 1 to 4 carbon atoms, and preferably at least methanesulfonic acid, more commonly designated by its acronym AMS.
- at least one alkanesulphonic acid chosen from linear or branched chain alkanesulphonic acids comprising 1 to 4 carbon atoms, and preferably at least methanesulfonic acid, more commonly designated by its acronym AMS.
- Said at least one alkanesulfonic acid which can be used in the process of the present invention can be used as such, or in combination with one or more other components, that is to say in formulation.
- Any type of formulation comprising at least one alkanesulphonic acid may be suitable.
- the formulation comprises from 0.01% to 100% by weight of alkanesulfonic acid, more generally from 0.05% to 90% by weight, in particular from 0.5% to 75% by weight, limits included, of alkanesulfonic acid (s)), relative to the total weight of said formulation. It is for example possible to use formulations comprising from 0.01% to 40% by weight of alkanesulfonic acid, better still from 0.05% to 30% by weight, more specifically from 0.5% to 20% by weight.
- alkanesulphonic acid limits included, of alkanesulphonic acid (s), relative to the total weight of said formulation
- the formulation is for example an aqueous, organic, or even hydro-organic formulation.
- the formulation can be prepared as a concentrated mixture, said concentrated mixture can be diluted by the end user.
- the formulation can also be a ready-to-use formulation, i.e. it does not need to be diluted.
- the formulation can be a pure alkanesulphonic acid, or a mixture of pure alkanesulphonic acids, that is to say that the formulation can contain only one or several sulfonic acids, without any other formulation additive or other solvent or diluent.
- the concentration of alkanesulfonic acid (s) in the formulation can vary widely. Those skilled in the art will know how to adapt, without undue effort, the appropriate concentration of acid in the formulation.
- concentrated solutions for example from 60% to 100%, preferably about 70% to 100% by weight of alkanesulfonic acid (s), relative to the weight total of said formulation, or less concentrated solutions of 0.01% to 60%, preferably from 0.05% to 45%, advantageously from 0.1% to 40% by weight of alkane- acid (s) sulphonic (s), relative to the total weight of said formulation.
- the acid of pK a less than or equal to 3.5 used is methanesulphonic acid (pK a of -1, 9).
- the methanesulfonic acid can advantageously be that marketed in aqueous solution by the company Arkema under the name Scaleva ® , or also under the name Lutropur ® marketed by the company BASF, ready for use or diluted with water in the proportions indicated above.
- the present invention relates to the use of an acid of pK a less than or equal to 3.5, preferably of an alkanesulphonic acid, and more preferably of methanesulphonic acid. , for the treatment of an alkoxylation reaction medium of a fatty chain compound of formula R-OH, where R is as defined above, and more particularly for the treatment of an alkoxylation reaction medium for the preparation of a compound of formula (1) as defined above.
- Step b) of treatment with an acid of pK a less than or equal to 3.5 can be carried out at various temperatures and pressures.
- the treatment temperature is advantageously between room temperature and 130 ° C, and more generally the roof temperature is between 30 ° C and 120 ° C, for example between 40 ° C and 100 ° C.
- the duration of treatment with the acid of pK a less than or equal to 3.5 can also vary widely.
- the duration of contact with said acid is generally short and is generally between a few minutes and a few hours, preferably between 5 minutes and 1 hour, for example approximately 30 minutes.
- the amount of acid required can vary within large proportions but is generally between 4.10 -3 and 0.1 mol per kg of reaction medium, preferably between 5.10 3 and 9.10 2 mol per kg of reaction medium, better still between 6.10 3 and 8.10 2 mol per kg of reaction medium.
- the acid of pK a less than or equal to 3.5 is a proton donor acid and therefore requires the presence of a small amount of water which, if it is not present in the within the reaction medium or provided by the acid formulation, can advantageously be added to the reaction medium, for example during the acid treatment.
- This amount of water, already present or added during the process of the invention can vary widely and is generally between a few ppm by weight and a few% by weight relative to the total weight of the reaction medium treated with the. acid of pK a less than 3.5.
- Step c) of recovering the alkoxylation product consists of treating the neutralized reaction medium as has just been defined above, that is to say the reaction medium resulting from step b) treated with an acid whose pK a is less than or equal to 3.5.
- the treatment of step c) corresponds to the elimination in whole or at least to a very large part, according to conventional techniques well known to those skilled in the art, of the impurities chemically transformed in step b) of the process of 'invention.
- the chemically transformed impurities are easily removed, in whole or at least in very large part, according to conventional techniques well known to those skilled in the art.
- inert gas in particular nitrogen
- water vapor or alternatively by distillation, optionally under reduced pressure
- step c) of recovering the compound of formula R- (Ak-0-) n H does not include the additional addition of water and / or other solvent, nor the separation of solid particles (salts or other residues) formed during the alkoxylation process of invention.
- Step c) of recovery of the compound of formula R- (Ak-0-) n H comprises the elimination in whole or at least in large part, of the compounds resulting from the acid treatment of the reaction crude which included impurities generally resp A nsables bad odors of alkoxylated compounds of high molecular weight, as defined above.
- step c) of recovering the compound of formula (1) comprises, and preferably consists of, removing the products formed during step b ) treatment with an acid of pK a less than or equal to 3.5, by steam stripping.
- This operation is generally carried out at a temperature between 50 ° C and 150 ° C, for example between 70 ° C and 125 ° C, at a pressure generally between 5 kPa and atmospheric pressure (i.e. approximately 100 kPa), preferably between 5 kPa and 50 kPa, for a period generally between a few tens of minutes and a few hours, more generally between one hour and 7 hours.
- Removal operations, other than stripping, of the undesirable products formed during step b) are of course possible, as long as they lead to the desired result, without however adversely affecting the purity and the quality of the alkoxylates synthesized. , and by responding to appropriate economic and environmental constraints.
- the process of the present invention has very many advantages and more particularly in that it makes it possible to achieve in a simple and efficient manner on the industrial level fatty chain alkoxylates of high molecular weight with high degrees of purity. , and in particular making it possible to meet increasingly stringent regulatory specifications, in particular in the fields of cosmetics and human and animal health in general.
- the method of the present invention is moreover simple to implement, economically inexpensive both in terms of operation and also of implementation.
- the process of the present invention is easily adaptable to existing equipment, in that it requires only minor adaptations compared to existing installations, in particular by adding a system making it possible to treat the reaction medium with an acid of pK a less than or equal to three and elimination of impurities including those formed during said acid treatment.
- the process of the present invention does not penalize, or at least to a negligible extent, the overall synthesis process, in terms of productivity.
- the process of the present invention thus makes it possible to achieve fatty chain alkoxylates of high molecular weight, and in particular compounds of formula (1) as defined above, with very low levels of impurities.
- all of the species of unsaturated ether type are transformed into chemical species (in particular aldehydes, hemi-acetals and acetals as indicated above), which are easily eliminated. by virtue of the treatment carried out in step c) of the method according to the present invention.
- the fatty chain alkoxylates of high molecular weight obtained according to the process of the present invention most often have a quantity of impurities originating from the treatment with the acid of pK a of less than 3.5, less than 500 ppm by weight, more generally less than 300 ppm by weight and most often less than 100 ppm by weight.
- the process of the present invention has made it possible to limit the presence of the impurities defined above to a value less than 50 ppm, or even 10 ppm, and even less than 5 ppm.
- the process of the invention thus allows the preparation, on an industrial scale, of compounds of interest which are the fatty-chain high molecular weight alkoxylates, with high degrees of purity. It is thus possible to envisage the use of said high purity alkoxylates as additives, chemical intermediates, surfactants, emulsifiers, demulsifiers, dispersants, detergents, accountants, hydrotropic agents, wetting agents, water control agents.
- Example 1 Industrial Synthesis of Stearic Acid at 120 EO (According to the Invention)
- 287.5 kg (1000 moles) of stearic acid (Radiacid 0417 from the company Oleon) are charged.
- the acid is melted by heating to 80 ° C.
- 2.5 kg of potassium hydroxide (85% KOH, in the form of granules (“prills”)) are then added.
- the reaction medium is dried at 110 ° C. under 40 mm of Hg (ie approximately 5.33 kPa).
- the reaction medium is then brought to 170 ° C.
- Example 1 the procedure is as in Example 1, for the preparation of 500 g of stearic acid at 120 EO, by reaction of stearic acid with ethylene oxide, and the catalyst of the reaction (potassium hydroxide). At the end of the reaction, cooking is carried out, and the catalyst is neutralized, as indicated in Example 1 with formic acid.
- Example 1 A new industrial test is carried out, as in Example 1, using AMS to neutralize the catalyst and to treat impurities of unsaturated ether type.
- AMS stearic acid
- the total amount of methanesulfonic acid used to neutralize the catalyst and treat unsaturated ether-type impurities is 9.25 kg of AMS 70% or 0.175 and 0.115% (6.25 kg) of water%.
- the steam stripping operation at 105-110 ° C, for 5 hours under reduced pressure of 100 mm of mercury (ie 13.33 kPa)
- the final product is drained. Unsaturated ether-type impurity is no longer detected and the final acetaldehyde content measured by NMR is 2 ppm.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2006854A FR3111901B1 (fr) | 2020-06-30 | 2020-06-30 | PROCÉdÉ D’ALCOXYLATION AMÉLIORÉ |
PCT/FR2021/051189 WO2022003288A1 (fr) | 2020-06-30 | 2021-06-29 | Procédé d'alcoxylation amélioré |
Publications (1)
Publication Number | Publication Date |
---|---|
EP4172237A1 true EP4172237A1 (fr) | 2023-05-03 |
Family
ID=72709570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21746073.2A Pending EP4172237A1 (fr) | 2020-06-30 | 2021-06-29 | Procédé d'alcoxylation amélioré |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230235119A1 (fr) |
EP (1) | EP4172237A1 (fr) |
CN (1) | CN115734978A (fr) |
BR (1) | BR112022024416A2 (fr) |
FR (1) | FR3111901B1 (fr) |
WO (1) | WO2022003288A1 (fr) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5410399A (en) * | 1977-06-24 | 1979-01-25 | Nippon Oil & Fats Co Ltd | Preparation of polyalkylene glycol derivative |
IS4687A (is) | 1998-03-13 | 1998-04-06 | Shell Internationale Research Maatschappij B.V. | Aðferð við framleiðslu á lyktarlitlum pólýeter pólýólum |
ES2257302T3 (es) | 1999-07-09 | 2006-08-01 | Dow Global Technologies Inc. | Polimerizacion de oxido de etileno utilizando catalizadores de cianuro metalico. |
US6977236B2 (en) | 2002-06-14 | 2005-12-20 | Shell Oil Company | Preparation of a double metal cyanide catalyst |
US9012695B2 (en) * | 2009-06-18 | 2015-04-21 | Huntsman International Llc | Process for neutralizing an unneutralised polyether polyol |
PL398518A1 (pl) | 2012-03-19 | 2013-09-30 | Hreczuch Wieslaw Mexeo | Sklad i sposób otrzymywania katalizatora oksyalkilenowania |
EP3587386B1 (fr) * | 2018-06-22 | 2023-04-19 | L'air Liquide, Société Anonyme Pour L'Étude Et L'exploitation Des Procédés Georges Claude | Procédé de production d'éthoxylates d'alcools gras |
-
2020
- 2020-06-30 FR FR2006854A patent/FR3111901B1/fr active Active
-
2021
- 2021-06-29 US US17/999,657 patent/US20230235119A1/en active Pending
- 2021-06-29 BR BR112022024416A patent/BR112022024416A2/pt unknown
- 2021-06-29 CN CN202180045857.3A patent/CN115734978A/zh active Pending
- 2021-06-29 WO PCT/FR2021/051189 patent/WO2022003288A1/fr unknown
- 2021-06-29 EP EP21746073.2A patent/EP4172237A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
FR3111901A1 (fr) | 2021-12-31 |
WO2022003288A1 (fr) | 2022-01-06 |
FR3111901B1 (fr) | 2023-02-17 |
US20230235119A1 (en) | 2023-07-27 |
CN115734978A (zh) | 2023-03-03 |
BR112022024416A2 (pt) | 2023-01-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0110749B1 (fr) | Procédé de préparation de produits d'addition d'époxydes et de composés hydroxyles | |
EP2760816B1 (fr) | Procede de preparation d'alkoxyphenol et d'alkoxyhydroxybenzaldehyde | |
FR2534923A1 (fr) | Ethers polyoxyalkyleniques du glycerol ou du 1,2-propanediol esterifies par un acide gras et/ou par l'acide isostearique, leur procede de fabrication ainsi que leur application comme epaississants ou solubilisants | |
RU2189375C2 (ru) | Получение сложных эфиров сорбитана и жирных кислот в качестве поверхностно-активных веществ | |
CA3079918C (fr) | Alcool secondaire alcoxyle | |
EP1062197A1 (fr) | Rectification d'acide (meth)acrylique avec addition d'un tensioactif | |
CA3079986A1 (fr) | Sulfates d'alcools secondaires alcoxyles | |
WO2022003288A1 (fr) | Procédé d'alcoxylation amélioré | |
EP0804399B1 (fr) | Procede d'hydroformylation d'une olefine en milieu biphasique | |
CN111253278A (zh) | 一种超高含量烷基醇酰胺、合成工艺及应用 | |
EP0373978A1 (fr) | Dispersions de résols phénoliques à basse teneur en formol | |
CA3038306C (fr) | Procede de fabrication de polyphenols alcoxyles | |
EP3060539A1 (fr) | Utilisation d'acide alcane-sulfonique pour la préparation d'alcool phénolique | |
EP4045476A1 (fr) | Alcools alcoxylés et coiffés | |
RU2684930C2 (ru) | Составы катализаторов, способы их приготовления и способы алкоксилирования спиртов с использованием этих катализаторов | |
FR2972191A1 (fr) | Procede de preparation d'une composition tensioactive a base de bio-tensioactifs non-ioniques d'origine naturelle | |
FR2594435A1 (fr) | Procede pour la fabrication d'hydroxylamines et produits ainsi obtenus | |
FR2702482A1 (fr) | Nouveau procede de preparation d'alkylpolyosides faiblement colores et a faible teneur en produits de degradation acide. | |
EP0047206B1 (fr) | Procédé de préparation d'aminoalcools polyoxaalkylés ou polyoxaarylés et leur application comme agents de complexation de cations | |
WO2018189495A1 (fr) | Procédé de greffage de polyphénols | |
EP0983777B1 (fr) | Procédé de traitement de fruits et légumes après récolte avec purification de produits phytosanitaires contaminés par des amines primaires aromatiques | |
FR2540104A1 (fr) | Synthese des ethers de polyols | |
FR2573067A1 (fr) | Procede de preparation de produits d'addition d'epoxydes et de composes organiques comprenant un atome d'hydrogene actif | |
WO2023232427A1 (fr) | Synthese de l'acide levulinique par hydratation d'alcool furfurylque en presence d'un catalyseur homogene acide et d'un solvant a base d'ether et/ou d'acetals | |
BE591635A (fr) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20221212 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20240305 |