EP4171232A4 - Formulierungen mit modifizierter freisetzung von modifizierten formen von trimetazidin - Google Patents

Formulierungen mit modifizierter freisetzung von modifizierten formen von trimetazidin Download PDF

Info

Publication number
EP4171232A4
EP4171232A4 EP21832842.5A EP21832842A EP4171232A4 EP 4171232 A4 EP4171232 A4 EP 4171232A4 EP 21832842 A EP21832842 A EP 21832842A EP 4171232 A4 EP4171232 A4 EP 4171232A4
Authority
EP
European Patent Office
Prior art keywords
modified
trimetazidine
release formulations
forms
modified release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21832842.5A
Other languages
English (en)
French (fr)
Other versions
EP4171232A1 (de
Inventor
Andrew D. LEVIN
Jaikrishna Patel
George MOONEY
Scott Herbig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imbria Pharmaceuticals Inc
Original Assignee
Imbria Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imbria Pharmaceuticals Inc filed Critical Imbria Pharmaceuticals Inc
Publication of EP4171232A1 publication Critical patent/EP4171232A1/de
Publication of EP4171232A4 publication Critical patent/EP4171232A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP21832842.5A 2020-06-30 2021-06-28 Formulierungen mit modifizierter freisetzung von modifizierten formen von trimetazidin Pending EP4171232A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063046117P 2020-06-30 2020-06-30
US202063046115P 2020-06-30 2020-06-30
US202163183299P 2021-05-03 2021-05-03
US202163183294P 2021-05-03 2021-05-03
PCT/US2021/039303 WO2022005926A1 (en) 2020-06-30 2021-06-28 Modified release formulations of modified forms of trimetazidine

Publications (2)

Publication Number Publication Date
EP4171232A1 EP4171232A1 (de) 2023-05-03
EP4171232A4 true EP4171232A4 (de) 2024-07-24

Family

ID=79315460

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21832842.5A Pending EP4171232A4 (de) 2020-06-30 2021-06-28 Formulierungen mit modifizierter freisetzung von modifizierten formen von trimetazidin

Country Status (8)

Country Link
EP (1) EP4171232A4 (de)
JP (1) JP2023531802A (de)
KR (1) KR20230028535A (de)
CN (1) CN116234555A (de)
AU (1) AU2021299197A1 (de)
CA (1) CA3187827A1 (de)
IL (1) IL299544A (de)
WO (1) WO2022005926A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250035269A (ko) * 2023-09-05 2025-03-12 주식회사 뉴캔서큐어바이오 트리메타지딘을 포함하는 코팅정 조성물 및 이의 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200138963A1 (en) * 2017-06-20 2020-05-07 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4743321B2 (ja) * 2006-06-09 2011-08-10 ウーツェーベー ファルマ ゲーエムベーハー フェソテロジンを含む安定した医薬組成物
PE20080669A1 (es) * 2006-09-08 2008-07-18 Drugtech Corp Composicion de liberacion sostenida que comprende levodopa
ITFI20130184A1 (it) * 2013-08-01 2015-02-02 Valpharma Internat S P A Una formulazione farmaceutica di gliclazide a rilascio modificato, somministrabile per via orale, e suo metodo di produzione.
ES2884973T3 (es) * 2016-03-09 2021-12-13 Nls Pharmaceutics Ag Comprimido multicapa de mazindol de IR/SR y su utilización para el tratamiento del trastorno por déficit de atención/hiperactividad (ADHD)
US10980747B2 (en) * 2017-11-27 2021-04-20 Shin-Etsu Chemical Co., Ltd. Composition for solid preparation, solid preparation, and method for producing the same
CN109908096A (zh) * 2017-12-12 2019-06-21 武汉武药科技有限公司 一种盐酸曲美他嗪缓释片及其制备方法
WO2020081361A1 (en) * 2018-10-17 2020-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200138963A1 (en) * 2017-06-20 2020-05-07 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism

Also Published As

Publication number Publication date
IL299544A (en) 2023-02-01
JP2023531802A (ja) 2023-07-25
KR20230028535A (ko) 2023-02-28
CN116234555A (zh) 2023-06-06
CA3187827A1 (en) 2022-01-06
WO2022005926A1 (en) 2022-01-06
AU2021299197A1 (en) 2023-02-02
EP4171232A1 (de) 2023-05-03

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