EP4161548A4 - Extraction de composés psychoactifs d'un champignon psychédélique - Google Patents

Extraction de composés psychoactifs d'un champignon psychédélique

Info

Publication number
EP4161548A4
EP4161548A4 EP21827107.0A EP21827107A EP4161548A4 EP 4161548 A4 EP4161548 A4 EP 4161548A4 EP 21827107 A EP21827107 A EP 21827107A EP 4161548 A4 EP4161548 A4 EP 4161548A4
Authority
EP
European Patent Office
Prior art keywords
psychedelic
fungus
extraction
psychoactive compounds
psychoactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21827107.0A
Other languages
German (de)
English (en)
Other versions
EP4161548A1 (fr
Inventor
Benjamin Lightburn
Ryan Moss
Lisa Ranken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psilo Scientific Ltd
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Priority to EP24152237.4A priority Critical patent/EP4339200A3/fr
Publication of EP4161548A1 publication Critical patent/EP4161548A1/fr
Publication of EP4161548A4 publication Critical patent/EP4161548A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
EP21827107.0A 2020-06-17 2021-06-16 Extraction de composés psychoactifs d'un champignon psychédélique Pending EP4161548A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24152237.4A EP4339200A3 (fr) 2020-06-17 2021-06-16 Extraction d'ethanol de composes psychoactifs a partir de champignon psilocybine

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US202063046089P 2020-06-30 2020-06-30
CA3088384A CA3088384C (fr) 2020-06-17 2020-07-29 Extraction de composes psychoactifs de champignons psilocybines
CA3089455A CA3089455C (fr) 2020-06-17 2020-08-07 Extraction au methanol de composes psychoactifs de champignons
PCT/CA2021/050822 WO2021253123A1 (fr) 2020-06-17 2021-06-16 Extraction de composés psychoactifs d'un champignon psychédélique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP24152237.4A Division EP4339200A3 (fr) 2020-06-17 2021-06-16 Extraction d'ethanol de composes psychoactifs a partir de champignon psilocybine

Publications (2)

Publication Number Publication Date
EP4161548A1 EP4161548A1 (fr) 2023-04-12
EP4161548A4 true EP4161548A4 (fr) 2024-04-24

Family

ID=72895839

Family Applications (2)

Application Number Title Priority Date Filing Date
EP21827107.0A Pending EP4161548A4 (fr) 2020-06-17 2021-06-16 Extraction de composés psychoactifs d'un champignon psychédélique
EP24152237.4A Pending EP4339200A3 (fr) 2020-06-17 2021-06-16 Extraction d'ethanol de composes psychoactifs a partir de champignon psilocybine

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP24152237.4A Pending EP4339200A3 (fr) 2020-06-17 2021-06-16 Extraction d'ethanol de composes psychoactifs a partir de champignon psilocybine

Country Status (6)

Country Link
EP (2) EP4161548A4 (fr)
AU (1) AU2021291583B2 (fr)
BR (1) BR112022025777A2 (fr)
CA (6) CA3124367C (fr)
MX (1) MX2022016531A (fr)
WO (2) WO2021253123A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022550463A (ja) 2019-10-01 2022-12-01 エンピリアン ニューロサイエンス， インコーポレイテッド トリプタミン発現を調整する真菌の遺伝子操作
US20230219889A1 (en) 2020-05-19 2023-07-13 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
IL299453A (en) 2020-06-17 2023-02-01 Psilo Scient Ltd Extraction and composition of psychoactive alkaloids with inhibited dephosphorylation
BR112022025782A2 (pt) * 2020-10-23 2024-01-30 Psilo Scient Ltd Processo para obtenção de uma solução de alcaloide psicoativo purificada
CA3197443A1 (en) 2020-12-28 2022-06-28 Psilo Scientific Ltd. Processes for extracting psychoactive alkaloids and preparation thereof into transmucosal forms
CA3127180C (fr) * 2021-08-06 2024-03-05 Psilo Scientific Ltd. Normalisation de l'evaporation preliminaire des composes psychoactifs extraits
WO2023055860A1 (fr) * 2021-09-28 2023-04-06 Joseph Girardi Procédés d'extraction de jus glacé et produits utilisant des champignons psychédéliques et fonctionnels
CA3133547A1 (fr) * 2021-10-07 2023-04-07 Psilo Scientific Ltd. Extraction liquide-liquide d'alcaloides psychoactifs purifies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB911946A (en) * 1958-02-21 1962-12-05 Sandoz Ltd Psilocybin and psilocin and processes for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU36879A1 (fr) 1958-02-21
CN101292727A (zh) * 2008-05-30 2008-10-29 曹晋忠 菌类乙醇提取物的粉体制备方法
US20190142851A1 (en) * 2017-11-16 2019-05-16 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid
GB2571696B (en) * 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB911946A (en) * 1958-02-21 1962-12-05 Sandoz Ltd Psilocybin and psilocin and processes for their preparation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JANIS FRICKE ET AL: "Production Options for Psilocybin: Making of the Magic", CHEMISTRY - A EUROPEAN JOURNAL, vol. 25, no. 4, 18 January 2019 (2019-01-18), DE, pages 897 - 903, XP055766088, ISSN: 0947-6539, DOI: 10.1002/chem.201802758 *
PELLEGRINI MANUELA ET AL: "Magic truffles or Philosopher's stones: a legal way to sell psilocybin?", vol. 5, no. 3, 28 February 2013 (2013-02-28), pages 182 - 185, XP009547892, ISSN: 1942-7611, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1400> [retrieved on 20120809], DOI: 10.1002/DTA.1400 *
PIOTR PAWEL WIECZOREK ET AL: "Bioactive Alkaloids of Hallucinogenic Mushrooms", 30 November 2015 (2015-11-30), XP009545779, ISBN: 978-0-444-63462-7, Retrieved from the Internet <URL:https://ebookcentral.proquest.com/lib/epo-ebooks/reader.action?docID=2036175&ppg=148> [retrieved on 20150427] *
PSILOCYBIN EXERT: "Formulating New 'Magic Mushroom' compositions", INTERNET CITATION, 13 February 2018 (2018-02-13), pages 1 - 7, XP009542154, Retrieved from the Internet <URL:https://web.archive.org/web/20200704105500/https://psilocybintechnology.com/formulating-new-magic-mushroom-compositions/> [retrieved on 20230305] *
See also references of WO2021253123A1 *
TSUJIKAWA KENJI ET AL: "Morphological and chemical analysis of magic mushrooms in Japan", vol. 138, no. 1-3, 30 November 2003 (2003-11-30), pages 85 - 90, XP009547895, ISSN: 0379-0738, Retrieved from the Internet <URL:https://api.elsevier.com/content/article/PII:S0379073803003785?httpAccept=text/plain> [retrieved on 20230919], DOI: 10.1016/J.FORSCIINT.2003.08.009 *

Also Published As

Publication number Publication date
EP4339200A3 (fr) 2024-03-27
CA3198238A1 (fr) 2021-12-23
CA3124367C (fr) 2022-04-26
WO2021253123A1 (fr) 2021-12-23
CA3123908C (fr) 2022-03-22
CA3089455A1 (fr) 2021-09-14
EP4161548A1 (fr) 2023-04-12
CA3124367A1 (fr) 2020-10-07
CA3088384C (fr) 2021-08-03
CA3089455C (fr) 2022-07-05
AU2021291583A1 (en) 2023-02-02
CA3161623A1 (fr) 2021-12-23
CA3123908A1 (fr) 2020-10-07
MX2022016531A (es) 2023-09-12
AU2021291583B2 (en) 2023-12-07
EP4339200A2 (fr) 2024-03-20
WO2021253124A1 (fr) 2021-12-23
CA3161623C (fr) 2023-04-04
CA3088384A1 (fr) 2020-10-07
BR112022025777A2 (pt) 2023-01-10

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RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PSILO SCIENTIFIC LTD

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20240326

RIC1 Information provided on ipc code assigned before grant

Ipc: C12P 17/10 20060101ALI20240320BHEP

Ipc: A61P 25/00 20060101ALI20240320BHEP

Ipc: A61K 45/06 20060101ALI20240320BHEP

Ipc: C12P 17/00 20060101ALI20240320BHEP

Ipc: C07F 9/572 20060101ALI20240320BHEP

Ipc: C07D 209/16 20060101ALI20240320BHEP

Ipc: B01D 11/02 20060101ALI20240320BHEP

Ipc: A61K 31/675 20060101ALI20240320BHEP

Ipc: A61K 31/4045 20060101ALI20240320BHEP

Ipc: A23L 31/00 20160101ALI20240320BHEP

Ipc: A61K 36/07 20060101AFI20240320BHEP