BR112022025782A2 - Processo para obtenção de uma solução de alcaloide psicoativo purificada - Google Patents

Processo para obtenção de uma solução de alcaloide psicoativo purificada

Info

Publication number
BR112022025782A2
BR112022025782A2 BR112022025782A BR112022025782A BR112022025782A2 BR 112022025782 A2 BR112022025782 A2 BR 112022025782A2 BR 112022025782 A BR112022025782 A BR 112022025782A BR 112022025782 A BR112022025782 A BR 112022025782A BR 112022025782 A2 BR112022025782 A2 BR 112022025782A2
Authority
BR
Brazil
Prior art keywords
psychoactive
purified
extract
psychoactive alkaloid
alkaloid
Prior art date
Application number
BR112022025782A
Other languages
English (en)
Inventor
Benjamin Lightburn
Lisa Ranken
Ryan Moss
Original Assignee
Psilo Scient Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3097246A external-priority patent/CA3097246C/en
Priority claimed from PCT/CA2021/050813 external-priority patent/WO2021253116A1/en
Application filed by Psilo Scient Ltd filed Critical Psilo Scient Ltd
Publication of BR112022025782A2 publication Critical patent/BR112022025782A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

processo para obtenção de uma solução de alcaloide psicoativo purificada. uma fonte de alcaloide psicoativo é usada para obter um extrato de alcaloide psicoativo. a fonte pode ser cogumelos psicodélicos, animais ou plantas ou um extrato anterior dos mesmos. os alcaloides psicoativos no extrato são adsorvidos em um material adsorvente, do qual são então eluídos para fornecer uma solução de alcaloide psicoativo purificada. o processo pode ser repetido com diferentes materiais adsorventes, diferentes valores de ph e diferentes solventes de eluição. os sólidos presentes no extrato são removidos em vários estágios por filtração ou centrifugação. a solução de alcaloide psicoativo purificada pode então ser concentrada em uma pasta e, em seguida, padronizada pela adição de excipientes e evaporação do solvente. o extrato padronizado resultante tem uma concentração específica de alcaloide psicoativo.
BR112022025782A 2020-10-23 2021-10-23 Processo para obtenção de uma solução de alcaloide psicoativo purificada BR112022025782A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA3097246A CA3097246C (en) 2020-10-23 2020-10-23 Process for obtaining a purified psychoactive alkaloid solution
PCT/CA2021/050813 WO2021253116A1 (en) 2020-06-17 2021-06-14 Compositions comprising psychoactive compounds from psychoactive organisms
PCT/CA2021/051495 WO2022082320A1 (en) 2020-10-23 2021-10-23 Process for obtaining a purified psychoactive alkaloid solution

Publications (1)

Publication Number Publication Date
BR112022025782A2 true BR112022025782A2 (pt) 2024-01-30

Family

ID=81291112

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022025782A BR112022025782A2 (pt) 2020-10-23 2021-10-23 Processo para obtenção de uma solução de alcaloide psicoativo purificada

Country Status (4)

Country Link
EP (1) EP4161549A4 (pt)
BR (1) BR112022025782A2 (pt)
MX (1) MX2023004350A (pt)
WO (1) WO2022082320A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101491647A (zh) * 2007-04-18 2009-07-29 北京和润创新医药科技发展有限公司 一种从中药麦角提取液中分离麦角总生物碱的方法
JP2022529662A (ja) * 2019-04-26 2022-06-23 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 二重グリカン結合ａａｖ２．５ベクターのための方法および組成物
CA3124367C (en) * 2020-06-17 2022-04-26 Psilo Scientific Ltd. Aqueous extraction of psychoactive compounds from psilocybin fungus

Also Published As

Publication number Publication date
EP4161549A1 (en) 2023-04-12
EP4161549A4 (en) 2023-11-29
MX2023004350A (es) 2023-09-12
WO2022082320A1 (en) 2022-04-28

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