EP4050997A4 - Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline - Google Patents

Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline Download PDF

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Publication number
EP4050997A4
EP4050997A4 EP20881057.2A EP20881057A EP4050997A4 EP 4050997 A4 EP4050997 A4 EP 4050997A4 EP 20881057 A EP20881057 A EP 20881057A EP 4050997 A4 EP4050997 A4 EP 4050997A4
Authority
EP
European Patent Office
Prior art keywords
treatment
receptor antagonists
endothelin receptor
ocular diseases
ocular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20881057.2A
Other languages
German (de)
English (en)
Other versions
EP4050997A1 (fr
Inventor
Sevgi GURKAN
David Floyd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perfuse Therapeutics Inc
Original Assignee
Perfuse Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perfuse Therapeutics Inc filed Critical Perfuse Therapeutics Inc
Priority to EP22176530.8A priority Critical patent/EP4094759A1/fr
Publication of EP4050997A1 publication Critical patent/EP4050997A1/fr
Publication of EP4050997A4 publication Critical patent/EP4050997A4/fr
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP20881057.2A 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline Pending EP4050997A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22176530.8A EP4094759A1 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962928092P 2019-10-30 2019-10-30
US202063068215P 2020-08-20 2020-08-20
PCT/US2020/058411 WO2021087399A1 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP22176530.8A Division-Into EP4094759A1 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline
EP22176530.8A Division EP4094759A1 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline

Publications (2)

Publication Number Publication Date
EP4050997A1 EP4050997A1 (fr) 2022-09-07
EP4050997A4 true EP4050997A4 (fr) 2022-11-30

Family

ID=75715356

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20881057.2A Pending EP4050997A4 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline
EP22176530.8A Pending EP4094759A1 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP22176530.8A Pending EP4094759A1 (fr) 2019-10-30 2020-10-30 Traitement de maladies oculaires à l'aide d'antagonistes du récepteur de l'endothéline

Country Status (9)

Country Link
US (3) US11738007B2 (fr)
EP (2) EP4050997A4 (fr)
JP (1) JP2022554277A (fr)
CN (2) CN114786480B (fr)
AU (1) AU2020373065A1 (fr)
CA (1) CA3158767A1 (fr)
IL (1) IL292350A (fr)
MX (1) MX2022005063A (fr)
WO (1) WO2021087399A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114786480B (zh) 2019-10-30 2024-03-29 珀弗斯治疗股份有限公司 使用内皮素受体拮抗剂治疗眼部疾病
WO2021158663A1 (fr) 2020-02-06 2021-08-12 Perfuse Therapeutics, Inc. Compositions pour le traitement de maladies oculaires
IL307997A (en) 2021-04-30 2023-12-01 Perfuse Therapeutics Inc Pharmaceutical preparations and intravitreal drug delivery systems for the treatment of eye diseases
CA3218398A1 (fr) * 2021-04-30 2022-11-03 Perfuse Therapeutics, Inc. Traitement de maladies oculaires a l'aide d'antagonistes du recepteur de l'endotheline

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20030176356A1 (en) * 2001-04-24 2003-09-18 University Of North Texas Health Science Center Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma
WO2016156639A1 (fr) * 2015-03-27 2016-10-06 Retinset, S.L. Formulation ophtalmique topique d'antagonistes du récepteur de l'endothéline
WO2021158663A1 (fr) * 2020-02-06 2021-08-12 Perfuse Therapeutics, Inc. Compositions pour le traitement de maladies oculaires

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US6162927A (en) 1994-08-19 2000-12-19 Abbott Laboratories Endothelin antagonists
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US6639082B2 (en) 2000-10-17 2003-10-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
CA2437085A1 (fr) * 2001-02-02 2002-08-15 Merck Patent Gesellschaft Mit Beschraenkter Haftung Preparation pharmaceutique comprenant des pyrazolo[4,3-d]pyrimidines et des antagonistes du recepteur de l'endotheline ou des thienopyrimidines et des antagonsites du recepteur del'endotheline
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
US20070260203A1 (en) 2006-05-04 2007-11-08 Allergan, Inc. Vasoactive agent intraocular implant
CA2904447C (fr) 2007-08-22 2017-01-03 Abbvie Deutschland Gmbh & Co Kg Therapie pour complications du diabete
CN102548553B (zh) 2009-04-30 2016-07-13 美国中西部大学 用于治疗糖尿病酮酸中毒的方法和组合物
WO2010144477A2 (fr) 2009-06-12 2010-12-16 Auspex Pharmaceuticals, Inc. Modulateurs sulfonylurée du récepteur de l'endothéline
EP2558104A4 (fr) 2010-04-12 2013-12-11 R Tech Ueno Ltd Procédé et composition ophtalmique pour traiter une maladie rétinienne
US20160331712A1 (en) * 2013-12-19 2016-11-17 Tassos Georgiou Compositions of omega 3 fatty acids to treat diseases which involve damage to the nervous system
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WO2019018350A1 (fr) * 2017-07-17 2019-01-24 Keith Roizman Administration topique d'agents thérapeutiques comprenant des peptides de pénétration cellulaire, destinés à être utilisés pour le traitement de la dégénérescence maculaire liée à l'âge et autres maladies oculaires
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CN114786480B (zh) 2019-10-30 2024-03-29 珀弗斯治疗股份有限公司 使用内皮素受体拮抗剂治疗眼部疾病
IL307997A (en) 2021-04-30 2023-12-01 Perfuse Therapeutics Inc Pharmaceutical preparations and intravitreal drug delivery systems for the treatment of eye diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030176356A1 (en) * 2001-04-24 2003-09-18 University Of North Texas Health Science Center Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma
WO2016156639A1 (fr) * 2015-03-27 2016-10-06 Retinset, S.L. Formulation ophtalmique topique d'antagonistes du récepteur de l'endothéline
WO2021158663A1 (fr) * 2020-02-06 2021-08-12 Perfuse Therapeutics, Inc. Compositions pour le traitement de maladies oculaires

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Also Published As

Publication number Publication date
US20220257505A1 (en) 2022-08-18
AU2020373065A1 (en) 2022-05-26
MX2022005063A (es) 2022-08-04
CA3158767A1 (fr) 2021-05-06
US20240189288A1 (en) 2024-06-13
US20220257568A1 (en) 2022-08-18
CN114786480A (zh) 2022-07-22
EP4050997A1 (fr) 2022-09-07
US11738007B2 (en) 2023-08-29
CN118203574A (zh) 2024-06-18
EP4094759A1 (fr) 2022-11-30
CN114786480B (zh) 2024-03-29
JP2022554277A (ja) 2022-12-28
IL292350A (en) 2022-06-01
WO2021087399A1 (fr) 2021-05-06

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