EP3866779A4 - Traitement de maladies neurologiques - Google Patents

Traitement de maladies neurologiques Download PDF

Info

Publication number
EP3866779A4
EP3866779A4 EP19873913.8A EP19873913A EP3866779A4 EP 3866779 A4 EP3866779 A4 EP 3866779A4 EP 19873913 A EP19873913 A EP 19873913A EP 3866779 A4 EP3866779 A4 EP 3866779A4
Authority
EP
European Patent Office
Prior art keywords
treatment
neurological diseases
neurological
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19873913.8A
Other languages
German (de)
English (en)
Other versions
EP3866779A1 (fr
Inventor
Richard James Mead
Pamela Jean SHAW
Claude Ogoe
Ning SHAN
Laura FERRAIUOLO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sheffield
Aclipse One Inc
Original Assignee
University of Sheffield
Aclipse One Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Sheffield, Aclipse One Inc filed Critical University of Sheffield
Publication of EP3866779A1 publication Critical patent/EP3866779A1/fr
Publication of EP3866779A4 publication Critical patent/EP3866779A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP19873913.8A 2018-10-19 2019-10-18 Traitement de maladies neurologiques Pending EP3866779A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862747961P 2018-10-19 2018-10-19
PCT/US2019/056996 WO2020081973A1 (fr) 2018-10-19 2019-10-18 Traitement de maladies neurologiques

Publications (2)

Publication Number Publication Date
EP3866779A1 EP3866779A1 (fr) 2021-08-25
EP3866779A4 true EP3866779A4 (fr) 2022-07-06

Family

ID=70283153

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19874129.0A Pending EP3866795A4 (fr) 2018-10-19 2019-10-18 Traitement de maladies neurologiques
EP19873913.8A Pending EP3866779A4 (fr) 2018-10-19 2019-10-18 Traitement de maladies neurologiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP19874129.0A Pending EP3866795A4 (fr) 2018-10-19 2019-10-18 Traitement de maladies neurologiques

Country Status (9)

Country Link
US (2) US20220265635A1 (fr)
EP (2) EP3866795A4 (fr)
JP (2) JP2022512765A (fr)
KR (2) KR20210102208A (fr)
CN (2) CN113286588A (fr)
AU (2) AU2019362051A1 (fr)
CA (2) CA3117109A1 (fr)
IL (2) IL282361A (fr)
WO (2) WO2020081973A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA126950C2 (uk) 2018-08-20 2023-02-22 Янссен Фармацевтика Нв Інгібітори міжбілкової взаємодії keap1-nrf2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010046710A1 (fr) * 2008-10-24 2010-04-29 University Of Sheffield Agents thérapeutiques contre des troubles neurologiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2606658A1 (fr) * 2006-10-13 2008-04-13 Mike Tyers Compositions et methodes pour traiter les troubles ou les dommages neurologiques
US9517279B2 (en) * 2010-04-14 2016-12-13 The Mclean Hospital Corporation 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof
WO2016022538A1 (fr) * 2014-08-04 2016-02-11 Duke University Compositions et méthodes d'identification et de traitement d'états pathologiques impliquant l'activité hsf1

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010046710A1 (fr) * 2008-10-24 2010-04-29 University Of Sheffield Agents thérapeutiques contre des troubles neurologiques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BAKER R S ET AL: "The Effect of Apomorphine on Blink Kinematics in Subhuman Primates with and without Facial Nerve Palsy", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 43, no. 9, 1 September 2002 (2002-09-01), pages 2933 - 2938, XP002752662, ISSN: 0146-0404 *
KYRIAZIS M: "Neuroprotective, anti-apoptotic effects of apomorphine", JOURNAL OF ANTI-AGING MEDICINE, MARY ANN LIEBERT, LARCHMONT, NY, US, vol. 6, no. 1, 1 January 2003 (2003-01-01), pages 21 - 28, XP003017771, ISSN: 1094-5458, DOI: 10.1089/109454503765361551 *
POSTMA A G ET AL: "2.255 Effects of apomorphine on neuropsychiatric and cognitive function in patients with Parkinson's disease", PARKINSONISM AND RELATED DISORDERS, ELSEVIER SCIENCE, OXFORD, GB, vol. 13, 1 January 2007 (2007-01-01), pages S113, XP022635975, ISSN: 1353-8020, [retrieved on 20070101], DOI: 10.1016/S1353-8020(08)70667-9 *
RICHARD J. MEAD ET AL: "S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis", FREE RADICAL BIOLOGY & MEDICINE, vol. 61, 1 August 2013 (2013-08-01), US, pages 438 - 452, XP055465348, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2013.04.018 *
See also references of WO2020081973A1 *

Also Published As

Publication number Publication date
KR20210102208A (ko) 2021-08-19
WO2020081973A1 (fr) 2020-04-23
EP3866779A1 (fr) 2021-08-25
EP3866795A1 (fr) 2021-08-25
CN113301893A (zh) 2021-08-24
CA3117109A1 (fr) 2020-04-23
EP3866795A4 (fr) 2022-08-24
IL282360A (en) 2021-06-30
US20220265635A1 (en) 2022-08-25
IL282361A (en) 2021-06-30
KR20210102206A (ko) 2021-08-19
CN113286588A (zh) 2021-08-20
AU2019362052A1 (en) 2021-05-27
CA3117020A1 (fr) 2020-04-23
AU2019362051A1 (en) 2021-05-27
WO2020081975A1 (fr) 2020-04-23
US20210353613A1 (en) 2021-11-18
JP2022512765A (ja) 2022-02-07
JP2022508936A (ja) 2022-01-19

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Ipc: C07D 221/18 20060101ALI20220602BHEP

Ipc: A61P 25/28 20060101ALI20220602BHEP

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