EP4045146A1 - Nouvelle utilisation cosmétique de la n-méthylglycine pour augmenter la diversité de la flore microbienne cutanée - Google Patents
Nouvelle utilisation cosmétique de la n-méthylglycine pour augmenter la diversité de la flore microbienne cutanéeInfo
- Publication number
- EP4045146A1 EP4045146A1 EP20799775.0A EP20799775A EP4045146A1 EP 4045146 A1 EP4045146 A1 EP 4045146A1 EP 20799775 A EP20799775 A EP 20799775A EP 4045146 A1 EP4045146 A1 EP 4045146A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- methylglycine
- advantageously
- scalp
- skin
- staphylococcus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 235000005985 organic acids Nutrition 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
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- 150000003904 phospholipids Chemical class 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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- 208000017520 skin disease Diseases 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
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- 229940098760 steareth-2 Drugs 0.000 description 1
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- 150000003445 sucroses Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- YEFOAORQXAOVJQ-UHFFFAOYSA-N wuweizischun A Natural products C1C(C)C(C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-UHFFFAOYSA-N 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
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- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the skin includes the scalp.
- the term “cutaneous microbial flora” means the strains of bacteria and / or yeast and / or of beneficial and mutualistic commensal fungi and / or pathogenic opportunistic strains, in particular the beneficial and mutualistic commensal strains chosen from: the phylum of actinobacteria comprising the Corynebacteriacease family, in particular the Corynebacterium genus, bacteria of the Micrococcaceae family, in particular the Micrococcus and / or Kocuria genera, bacteria of the Propionibacteriaceae family with the propionibacterium or Cutibacterium genus, bacteria of the Brevibacteriaceae family in particular the genus Brevibacterium.
- the use of N-methylglycine is to increase the diversity of the cutaneous microbial flora to decrease and / or prevent the fall of the cutaneous appendages, preferably of the hair.
- N-methylglycine is to increase the diversity of the skin microbial flora, advantageously of the scalp, to prevent the appearance and / or reduce dandruff.
- N-methylglycine is considered to be in an effective amount for preventing the appearance and / or reducing dandruff when the concentration ratio of the strains of Staphylococcus (any species) / P. acnes is at least two times less, advantageously at least 3 times less important after application of a formulation comprising N-methylglycine, than said ratio measured after application of the same formulation not comprising N-methylglycine.
- this is a measurement of the concentration ratio of the strains of Staphylococcus (any species) / P.
- acceptable is understood to mean a cosmetic excipient which is non-irritant to the skin, does not induce an allergic response and is chemically stable.
- the cosmetic composition is applied to all or part of the scalp and / or of the skin appendages, advantageously of the scalp.
- the measurement of the percentage of adhesion of S. aureus is carried out in the presence of two distinct concentrations of N-methylglycine, at the level of human keratinocytes, under the conditions described in Example 3 .
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1911460A FR3101775A1 (fr) | 2019-10-15 | 2019-10-15 | Nouvelle utilisation cosmétique de la N-méthylglycine pour augmenter la diversité de la flore microbienne cutanée |
| FR1913955A FR3101776B1 (fr) | 2019-10-15 | 2019-12-09 | Nouvelle utilisation cosmétique de la N-méthylglycine pour augmenter la diversité de la flore microbienne cutanée |
| PCT/FR2020/051836 WO2021074532A1 (fr) | 2019-10-15 | 2020-10-15 | Nouvelle utilisation cosmétique de la n-méthylglycine pour augmenter la diversité de la flore microbienne cutanée |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4045146A1 true EP4045146A1 (fr) | 2022-08-24 |
Family
ID=69158103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP20799775.0A Pending EP4045146A1 (fr) | 2019-10-15 | 2020-10-15 | Nouvelle utilisation cosmétique de la n-méthylglycine pour augmenter la diversité de la flore microbienne cutanée |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4045146A1 (zh) |
| JP (1) | JP2022551825A (zh) |
| KR (1) | KR20220082832A (zh) |
| CN (1) | CN114555042B (zh) |
| FR (2) | FR3101775A1 (zh) |
| WO (1) | WO2021074532A1 (zh) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10217131A1 (de) * | 2001-07-31 | 2003-02-13 | Kuhs Kosmetik Gmbh & Co Kg | Topisch applizierbare Zusammensetzung sowie Werkstoffgemisch |
| US20040228822A1 (en) * | 2003-05-16 | 2004-11-18 | Khaiat Alain V. | Topical treatment of skin conditions |
| DE10333245C5 (de) * | 2003-07-21 | 2015-02-19 | Henkel Ag & Co. Kgaa | Präbiotisch wirksame Pflanzenextrakte |
| EP1736537A1 (en) * | 2005-06-22 | 2006-12-27 | OrganoBalance GmbH | Methods and means for protecting the skin against pathogenic microorganisms |
| ES2345671T3 (es) * | 2005-12-16 | 2010-09-29 | Unilever N.V. | Composiciones de tratamiento para el cabello. |
| DE102014211204A1 (de) * | 2014-06-12 | 2015-12-17 | Henkel Ag & Co. Kgaa | Verwendung kosmetischer Reinigungszusammensetzungen als Präbiotikum |
| FR3064473B1 (fr) * | 2017-04-03 | 2021-02-12 | Basf Beauty Care Solutions France Sas | Ingredient protecteur de l'equilibre de la flore microbienne cutanee et/ou mucosale |
-
2019
- 2019-10-15 FR FR1911460A patent/FR3101775A1/fr active Pending
- 2019-12-09 FR FR1913955A patent/FR3101776B1/fr active Active
-
2020
- 2020-10-15 EP EP20799775.0A patent/EP4045146A1/fr active Pending
- 2020-10-15 KR KR1020227012203A patent/KR20220082832A/ko unknown
- 2020-10-15 JP JP2022520030A patent/JP2022551825A/ja active Pending
- 2020-10-15 CN CN202080071282.8A patent/CN114555042B/zh active Active
- 2020-10-15 WO PCT/FR2020/051836 patent/WO2021074532A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114555042B (zh) | 2024-03-05 |
| FR3101776B1 (fr) | 2021-10-29 |
| KR20220082832A (ko) | 2022-06-17 |
| JP2022551825A (ja) | 2022-12-14 |
| FR3101775A1 (fr) | 2021-04-16 |
| FR3101776A1 (fr) | 2021-04-16 |
| CN114555042A (zh) | 2022-05-27 |
| WO2021074532A1 (fr) | 2021-04-22 |
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