EP3972984C0 - Verfahren zur herstellung von galnac-phosphoramidit-epimere - Google Patents

Verfahren zur herstellung von galnac-phosphoramidit-epimere

Info

Publication number
EP3972984C0
EP3972984C0 EP20725557.1A EP20725557A EP3972984C0 EP 3972984 C0 EP3972984 C0 EP 3972984C0 EP 20725557 A EP20725557 A EP 20725557A EP 3972984 C0 EP3972984 C0 EP 3972984C0
Authority
EP
European Patent Office
Prior art keywords
phosphoramitite
galnac
epimere
preparation
phosphoramitite epimere
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20725557.1A
Other languages
English (en)
French (fr)
Other versions
EP3972984A1 (de
EP3972984B1 (de
Inventor
Simon Adolf Breitler
Kurt Puentener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP3972984A1 publication Critical patent/EP3972984A1/de
Application granted granted Critical
Publication of EP3972984C0 publication Critical patent/EP3972984C0/de
Publication of EP3972984B1 publication Critical patent/EP3972984B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EP20725557.1A 2019-05-20 2020-05-18 Verfahren zur herstellung von galnac-phosphoramidit-epimere Active EP3972984B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19175309 2019-05-20
PCT/EP2020/063749 WO2020234208A1 (en) 2019-05-20 2020-05-18 Process for the preparation of galnac phosphoramidite epimers

Publications (3)

Publication Number Publication Date
EP3972984A1 EP3972984A1 (de) 2022-03-30
EP3972984C0 true EP3972984C0 (de) 2026-03-04
EP3972984B1 EP3972984B1 (de) 2026-03-04

Family

ID=66625050

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20725557.1A Active EP3972984B1 (de) 2019-05-20 2020-05-18 Verfahren zur herstellung von galnac-phosphoramidit-epimere

Country Status (13)

Country Link
US (1) US12139506B2 (de)
EP (1) EP3972984B1 (de)
JP (1) JP7558201B2 (de)
KR (1) KR20220010496A (de)
CN (1) CN113840828B (de)
AR (1) AR118949A1 (de)
AU (1) AU2020278797B2 (de)
CA (1) CA3134494A1 (de)
IL (1) IL288116B2 (de)
MX (1) MX2021014111A (de)
SG (1) SG11202110680PA (de)
TW (1) TWI869403B (de)
WO (1) WO2020234208A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250161461A1 (en) * 2022-01-30 2025-05-22 Rona Bioscience, Limited Targeting ligand containing n-acetylgalactosamine
WO2024075760A1 (ja) * 2022-10-05 2024-04-11 第一三共株式会社 ２分岐型ｎ－アセチル－ｄ－ガラクトサミン構造を有する化合物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3331892T3 (pl) * 2015-08-06 2019-11-29 Hoffmann La Roche Sposób wytwarzania pochodnych kwasu GalNAc
ES2848122T3 (es) * 2015-11-16 2021-08-05 Hoffmann La Roche Fosforamidita de agrupación de GalNAc
WO2018215049A1 (en) * 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates

Also Published As

Publication number Publication date
CN113840828A (zh) 2021-12-24
SG11202110680PA (en) 2021-10-28
TW202110483A (zh) 2021-03-16
AR118949A1 (es) 2021-11-10
CN113840828B (zh) 2024-01-16
JP2022533220A (ja) 2022-07-21
IL288116B2 (en) 2025-03-01
TWI869403B (zh) 2025-01-11
AU2020278797A1 (en) 2021-10-07
EP3972984A1 (de) 2022-03-30
KR20220010496A (ko) 2022-01-25
AU2020278797B2 (en) 2025-06-05
EP3972984B1 (de) 2026-03-04
WO2020234208A1 (en) 2020-11-26
IL288116B1 (en) 2024-11-01
MX2021014111A (es) 2021-12-10
CA3134494A1 (en) 2020-11-26
US12139506B2 (en) 2024-11-12
IL288116A (en) 2022-01-01
JP7558201B2 (ja) 2024-09-30
US20220259248A1 (en) 2022-08-18

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