EP3931106A1 - Ensemble formant machine et procédé pour remplir et fermer des récipients - Google Patents

Ensemble formant machine et procédé pour remplir et fermer des récipients

Info

Publication number
EP3931106A1
EP3931106A1 EP20716443.5A EP20716443A EP3931106A1 EP 3931106 A1 EP3931106 A1 EP 3931106A1 EP 20716443 A EP20716443 A EP 20716443A EP 3931106 A1 EP3931106 A1 EP 3931106A1
Authority
EP
European Patent Office
Prior art keywords
containers
lock
machine arrangement
housing
filled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20716443.5A
Other languages
German (de)
English (en)
Other versions
EP3931106B1 (fr
Inventor
Matthias Schwandt
Steffen Haefelein
Bjoern Krause
Christopher Klemm
Andreas Kuba
Sebastian GRAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntegon Technology GmbH
Original Assignee
Syntegon Technology GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntegon Technology GmbH filed Critical Syntegon Technology GmbH
Publication of EP3931106A1 publication Critical patent/EP3931106A1/fr
Application granted granted Critical
Publication of EP3931106B1 publication Critical patent/EP3931106B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/003—Packaging lines, e.g. general layout
    • B65B65/006—Multiple parallel packaging lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers

Definitions

  • the present invention relates to a machine arrangement and a method for filling and closing containers, in particular of
  • Machine arrangements for filling and closing containers are known from the prior art in different configurations.
  • pharmaceutical sector there is a clear trend towards small batch filling, as new or personalized oncology or autoimmune therapies require an individual combination of pharmaceutical products.
  • Previous machine concepts for filling and closing containers are usually based on a series arrangement in which the container passes through several processing stations in a row, with transport or handling steps being necessary between the individual stations.
  • Such a machine arrangement is known, for example, from EP 2280873 B1.
  • the area used by the machine arrangement is clear in comparison with the prior art reduced.
  • the cycle times for filling and closing the containers can be significantly reduced in comparison with the prior art.
  • empty journeys by handling devices are minimized or completely eliminated.
  • the machine arrangement according to the invention has increased flexibility and can in particular without
  • Closing of containers and a handling device for loading and unloading the containers into and out of the machine arrangement Closing of containers and a handling device for loading and unloading the containers into and out of the machine arrangement.
  • the handling device is set up to handle containers from one side of the
  • the processing station has at least one work area for receiving a container at which the container is filled and closed.
  • the processing station also has a storage area in which the filled and closed container is temporarily stored.
  • the handling device is set up to supply empty containers to the processing station and to remove filled and closed containers from the storage area. Since the
  • Handling device is set up to supply and remove the containers from one side of the machine arrangement, significantly reduced cycle times can be achieved and in particular empty runs can be avoided, and format parts and space requirements, in particular a footprint, can be optimized.
  • the processing station particularly preferably further comprises a weighing station for weighing empty and / or filled containers.
  • the weighing station is preferably arranged directly at the filling station, so that the weighing process can already be carried out during the filling process.
  • the processing station further preferably further comprises one
  • Inspection device for checking the condition of the empty and / or filled containers.
  • the inspection device is preferably a visual one
  • the machine arrangement further preferably comprises a format receptacle with several receptacle locations for individual containers. There are preferably four receiving spaces in the format receptacle. Particularly preferred are two receiving spaces for empty containers, which are filled and closed, and two receiving spaces for already filled and closed containers.
  • a number of processing stations in the is further preferred.
  • Processing station half the size of a number of mounting positions in the format holder. That is, if a total of four
  • the processing station has exactly two workstations.
  • the holding device also preferably has a plurality of individually controllable grippers, the number of grippers being equal to the number of
  • Processing station is. In this way, individual control of grippers and thus handling of individual containers can be implemented.
  • the handling device is preferably a robot arm or, alternatively, a transport slide.
  • One or more manipulator towers are preferably provided on the transport carriage.
  • the manipulator towers can also be arranged to be rotatable, in particular rotatable by 90 °.
  • a turning station with at least two,
  • the turning station is preferably set up to take up the entire format receptacle with multiple receptacles and to turn it through 180 °.
  • the machine arrangement further preferably comprises a closed housing with a first lock.
  • the empty containers are on top of the first
  • Lock is fed into the housing and the filled and closed containers are discharged via the first lock.
  • Such a one Machine arrangement is used in particular in the pharmaceutical sector. Possibly. the interior of the housing can be made sterile.
  • the machine arrangement further preferably comprises a second lock, empty containers being fed into the housing via the second lock and the filled and closed containers being discharged via the second lock. Containers can thus be fed into and removed from the housing from two sides.
  • the machine arrangement particularly preferably further comprises a
  • Control device which is set up as a function of a type of
  • Container and / or a type of feed to be operated in one of three operating modes A first operating mode is designed in such a way that empty containers pass through the first lock into the housing of the
  • Machine assembly are introduced and filled and closed containers through the first lock from the machine assembly
  • a second operating mode is designed in such a way that empty containers are channeled through this second lock into the housing of the machine arrangement and filled and closed containers are discharged from the machine assembly again through the second lock.
  • a third operating mode is also designed so that empty containers through one of the two locks into the housing of the
  • Machine assembly are introduced and filled and closed containers through the other of the two locks from the
  • Machine arrangement are discharged.
  • three different operating modes can be provided in which containers are fed and removed exclusively from a single side or are passed through the machine arrangement in the container using the continuous principle.
  • the machine arrangement particularly preferably comprises a first and a second additional module, the first additional module being arranged on the first lock and the second additional module being arranged on the second lock.
  • the first additional module is set up, format recordings for
  • the additional module is set up to handle only isolated containers.
  • Receipt of a large number of containers can be processed via the first additional module and individual or isolated containers can be processed further through the machine arrangement via the second additional module. It is thus possible with a single machine arrangement to process both larger batches and small batches by feeding them via the different additional modules.
  • each of the several machine arrangements were always necessary for this, each of the several machine arrangements either being able to process containers from format receptacles or being able to process individual containers.
  • the containers are preferably vials, syringes, cartridges, small containers, special containers or the like.
  • the present invention also relates to a method for filling
  • Closing of containers, in particular pharmaceutical containers, in a processing station which can be carried out in one of three operating modes.
  • a first operating mode is designed in such a way that
  • Containers are channeled through the first lock into the housing of the machine arrangement and filled and closed containers are discharged from the machine arrangement again through the first lock.
  • a second operating mode is designed to smuggle containers through the second lock into the housing of the machine arrangement and filled and closed containers out of the machine again through this second lock
  • a third operating mode is designed to channel empty containers through the first lock into the housing of the machine arrangement and to channel filled and closed containers out of the housing of the machine assembly again through the second lock. This can do that
  • both locks for clean room applications are understood, in which undesired contamination of the clean room inside the housing of the machine arrangement is to be avoided, as well as, in particular closable, openings in housings through which containers can be introduced into the housing and removed from the housing again can be.
  • the method further preferably has the step of arranging the filled and closed container on a storage area of the
  • Processing station from which the filled and closed container is then removed.
  • Figure 1 is a schematic representation of a machine arrangement according to a first preferred embodiment of the invention in a first state
  • FIG. 2 is a schematic representation of the machine arrangement from FIG.
  • FIG. 3 shows a schematic representation of a machine arrangement according to a second exemplary embodiment of the invention
  • FIG. 4 shows a schematic representation of a machine arrangement according to a third exemplary embodiment of the invention.
  • Machine arrangement 1 according to a first preferred embodiment of the invention described in detail.
  • the machine arrangement 1 comprises a
  • the machine arrangement 1 further comprises a closed housing 10 with four sides, a first lock 11 being arranged on one side. As indicated by arrows A and B in FIG. 1, the containers are only supplied and removed via the first lock 11.
  • the processing station 2 comprises a filling station 20 and a
  • Closure station 23 Depending on the type of container, a corresponding closure is applied to the container in the closure station 23 and the container is thus closed.
  • the machine arrangement 1 further comprises a work station area 4, which is arranged directly in front of the filling station 20 and the closing station 23.
  • the closing station 23 comprises a vibratory conveyor 24 which feeds the closing bodies, for example stoppers or the like, to the filled container so that they can be closed in the closing station 23.
  • the machine arrangement 1 further comprises a storage area 5 for the intermediate storage of filled and closed containers. These filled and closed containers are then carried out of the housing 10 of the machine arrangement 1 from the storage area 5 via the first lock 11.
  • the processing station 2 also includes a path station 7, which is arranged at the filling station 20.
  • An inspection station 8 is also provided.
  • the inspection station 8 of this embodiment is a visual inspection station. It should be noted, however, that additional
  • Inspection facilities e.g. for the closure, damage to the container, residual oxygen content in the container after filling,
  • a closed container can be provided.
  • a first processing station 21 and a second processing station 22 are provided in front of the filling station 20.
  • Each of the two processing stations 21 22 is set up to accommodate an empty container 9.
  • These empty containers 9 are then filled at the first and second processing stations.
  • the filled containers are then transported to the closing station 23.
  • the handling device 3 in the machine arrangement 1 comprises a slide 30.
  • Three manipulator towers 31, 32 and 33 are arranged on the slide 30.
  • Each of the manipulator towers 31, 32, 33 has two individually controllable grippers 34.
  • the grippers 34 can this container 9 from the
  • Remove format holder 6 and, for example, filled and / or
  • the first manipulator tower 31 can also remove containers 9 from the machine arrangement 1 via the first lock 11 and feed empty, new containers 9 into the machine arrangement 1 via the first lock 11.
  • the format receptacle 6 has four receptacles, namely a first
  • Receiving place 61 a second receiving place 62, a third
  • Receiving location 63 and a fourth receiving location 64 are provided for feeding the containers to the processing station, and the two third and fourth
  • Containers from the machine arrangement 1 are provided.
  • the machine arrangement 1 also comprises a turning station 50.
  • the turning station 50 is arranged in the parking area 5 in the machine arrangement 1.
  • the turning station 50 enables a turn by 180 °. This establishes a position for the reception areas Format recording 6, if this is located on the storage area 5 and is turned, interchanged.
  • the respective manipulator towers 31, 32, 33 can then transport the filled and closed containers 9 to the first lock 11 and discharge them out of the machine arrangement 1.
  • the format receptacle 6 By providing at least two different receiving spaces on the format receptacle 6, namely at least one space for an empty container that is to be filled and closed and one space for a filled and closed container, it is possible that the format receptacle as it passes through the machine arrangement 1 is never completely empty. Either both empty containers and filled and closed containers are arranged on the format holder 6 or only empty containers and empty spaces are provided for filled and closed containers to be received later or there are empty spaces for empty containers and occupied receiving spaces for filled and closed containers .
  • the machine arrangement 1 is particularly suitable for filling
  • Double arrow D indicated can be moved linearly in both directions.
  • the first manipulator tower 31 moves back and forth between the first lock 11 and the filling station 20, the second manipulator tower 32 between the
  • Manipulator tower 33 back and forth between the locking station 23 and the storage area 5. By turning through 180 ° at the turning station 50, the filled and closed containers can be transported back from the third
  • Manipulator tower to the first manipulator tower and from the first
  • Manipulator tower can be realized from the machine arrangement 1.
  • machine arrangement 1 can also have a second lock 12, which is shown in dashed lines in FIGS. 1 and 2. Containers could then also be fed in and removed through the second lock.
  • Figure 3 shows a machine arrangement 1 according to a second
  • Embodiment of the invention are identical or functionally identical parts denoted by the same reference numerals as in the first embodiment.
  • the same reference numerals as in the first embodiment.
  • Machine arrangement 1 of the second exemplary embodiment has a different handling device 3.
  • the handling device 3 this
  • the exemplary embodiment comprises three robots 301, 302 and 303.
  • the first robot 301 is responsible for feeding the containers into the machine arrangement 1 via the first lock 11 and removing them from the machine arrangement 1.
  • the second robot 302 takes over the format pick-up 6 from the first robot 301 and guides the empty containers to the filling station 20.
  • the third robot 303 takes the then filled containers from the filling station 20 and transfers them to the closing station 23, where they are closed.
  • the first robot 301 then takes the filled and closed containers from the storage area 5 and feeds them through the first lock 11 on the same side of the
  • Machine arrangement 1 from which the containers were also introduced.
  • Figure 4 shows a machine arrangement 1 according to a third
  • the machine arrangement 1 of the third exemplary embodiment comprises a
  • the handling device 3 comprises a total of three Scara robots 201, 202 and 203. All three Scara robots 201, 202, 203 have the same structure.
  • the Scara robots are constructed more simply than the robots shown in the second exemplary embodiment, the Scara robots 201, 202, 203 enabling handling essentially in a horizontal plane.
  • the machine arrangement of the third embodiment comprises, as can be seen from Figure 4, a first lock 11 and a second lock 12. Die Both locks are arranged opposite one another on the housing 10 of the machine arrangement.
  • the machine arrangement 1 of the third exemplary embodiment further comprises a first additional module 101 and a second
  • a control unit 100 is set up to control the three Scara robots 201, 202, 203.
  • the first additional module 101 is arranged on the first lock 11.
  • the first additional module is set up to handle format receptacles for receiving a large number of containers.
  • individual containers are removed from the format receptacle, which can be a tray or the like, for example, and channeled into the interior of the housing 10 of the machine arrangement 1 via the first lock 11.
  • the second additional module 102 is set up to handle isolated containers. These can be containers, for example, which are separated by means of a star wheel or robot.
  • the first additional module 101 is thus set up to handle a large number of containers.
  • the second additional module 102 is set up to handle only a small number of isolated containers.
  • the control unit 100 is set up to select one of three operating modes and to operate the machine arrangement accordingly.
  • a first operating mode is designed in such a way that empty containers are channeled through the first lock 11 into the housing 10 of the machine arrangement and filled and closed containers are discharged from the machine assembly again through the first lock 11.
  • the containers from the first additional module 101 are channeled into the interior of the housing 10 via the first lock 11 according to the arrow A and transported to the processing stations 21, 22 by turning them 90 ° according to the arrow C. After filling on the processing stations 21, 22, the filled containers are used
  • the closed containers are then fed to the turning station 50 (arrow E) and turned there. Then there is a return transport in accordance with the double arrows E, D and C for discharging again via the first lock 11 (arrow B) back to the first additional module 101.
  • the containers filled and closed in this way can then be stored in a format holder with a large number of spaces.
  • the second lock 12 is closed during the first operating mode.
  • a second operating mode of the control device 100 is designed in such a way that containers are introduced into the housing 10 of the machine arrangement 1 from the second additional module 102 via a second lock 12 in accordance with the arrow H. The empty containers are then transferred to the third Scara robot 203 and the second Scara robot 202
  • the filled containers are then conveyed to the closing station 23 (arrow D) and from there via the turning station 50 (arrow F) or alternatively or directly by means of the third Scara robot 203 via the second lock 12 back to the second additional module 102 (arrow G ).
  • the first lock 11 is closed during the second operating mode.
  • a third operating mode of the control device 100 is a
  • the operating mode only individual containers are fed from the additional module 102 into the processing station 2 and transported back to the second additional module.
  • the second operating mode is particularly suitable for use in small batches.
  • a continuous mode can then be carried out through the machine arrangement 1, in which, for example, a large number of containers are arranged in a format receptacle and, after filling and closing, individual containers are discharged via the second additional module 102.
  • a high degree of variability in the choice of the containers to be filled can thus be achieved, although different machine arrangements have always been necessary in the prior art.
  • Additional module 102 can be provided by the processing station 2 in the direction of the first additional module 101. Furthermore, the

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)

Abstract

L'invention concerne un ensemble formant machine, en particulier pour traiter des produits pharmaceutiques. L'ensemble formant machine comprend une station de traitement (2) pour remplir et fermer des récipients (9), en particulier avec des produits pharmaceutiques, un dispositif de manutention (3) pour amener et évacuer les récipients dans l'ensemble formant machine. Le dispositif de manutention (3) est mis au point pour amener depuis précisément un côté de l'ensemble formant machine des récipients dans l'ensemble formant machine et les évacuer. La station de traitement (2) comporte au moins une zone de travail (4) pour recevoir un récipient vide, sur laquelle le récipient vide est rempli et fermé. La station de traitement (2) comporte au moins une zone de rangement (5) pour entreposer temporairement des récipients remplis et fermés. Le dispositif de manutention (3) est mis au point pour amener à la station de traitement (2) des récipients (9) vides et pour évacuer de la zone de rangement (5) des récipients remplis et fermés.
EP20716443.5A 2019-05-18 2020-03-31 Agencement de machine et procédé de remplissage et d'étanchéité de récipients Active EP3931106B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102019207282.8A DE102019207282A1 (de) 2019-05-18 2019-05-18 Maschinenanordnung und Verfahren zum Füllen und Verschließen von Behältnissen
PCT/EP2020/059117 WO2020233881A1 (fr) 2019-05-18 2020-03-31 Ensemble formant machine et procédé pour remplir et fermer des récipients

Publications (2)

Publication Number Publication Date
EP3931106A1 true EP3931106A1 (fr) 2022-01-05
EP3931106B1 EP3931106B1 (fr) 2024-05-29

Family

ID=70154404

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20716443.5A Active EP3931106B1 (fr) 2019-05-18 2020-03-31 Agencement de machine et procédé de remplissage et d'étanchéité de récipients

Country Status (6)

Country Link
US (1) US20220212818A1 (fr)
EP (1) EP3931106B1 (fr)
CN (1) CN113993787B (fr)
CA (1) CA3136505A1 (fr)
DE (1) DE102019207282A1 (fr)
WO (1) WO2020233881A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102020131098A1 (de) 2020-11-24 2022-05-25 Syntegon Technology Gmbh Vorrichtung zum Verschließen von pharmazeutischen Behältnissen
IT202100000311A1 (it) * 2021-01-11 2022-07-11 Pharma Integration S R L Dispositivo per spostare contenitori, apparato e metodo per produrre articoli farmaceutici o biotecnologici

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JP4768175B2 (ja) * 2001-09-27 2011-09-07 株式会社ミューチュアル 容器への薬液充填施栓システム
DE10330700A1 (de) * 2003-07-08 2005-01-27 Robert Bosch Gmbh Maschine zum Füllen und Verschließen von Verpackungen
DE102006039120B4 (de) * 2006-08-21 2017-11-23 Robert Bosch Gmbh Abfüllmaschine mit verbesserter Beschickung
US20090223592A1 (en) * 2008-03-04 2009-09-10 Vanrx Pharmaceuticals, Inc. Robotic filling systems and methods
DE102008001287A1 (de) * 2008-04-21 2009-10-22 Robert Bosch Gmbh Füll- und Verschließmaschine für Behälter
DE102009027452A1 (de) * 2009-07-03 2011-01-05 Robert Bosch Gmbh Vorrichtung zum Füllen und Verschließen von pharmazeutischen Bahältnissen
DE102009045947A1 (de) * 2009-10-23 2011-04-28 Robert Bosch Gmbh Vorrichtung zum Befüllen und Verschließen von Behältnissen
EP2420450A1 (fr) * 2010-08-17 2012-02-22 Aseptic Technologies Appareil de remplissage d'un produit dans un conteneur dans des conditions aseptiques
US20180072446A1 (en) * 2016-09-13 2018-03-15 Vanrx Pharmasystems Inc. Apparatus and method for asepticaly filling pharmaceutical containers with a pharmaceutical fluid using rotary stage
DE102013211526A1 (de) * 2013-06-19 2014-12-24 Robert Bosch Gmbh Vorrichtung und Verfahren zur Gewichtsbestimmung insbesondere eines mit Produkt befüllten Behältnisses
CA2921554C (fr) * 2013-08-16 2021-02-16 Vanrx Pharmasystems Inc. Procede, dispositif et systeme de remplissage de contenants pharmaceutiques
US10858132B2 (en) * 2013-10-18 2020-12-08 Pall Life Sciences Belgium Bvba Disposable production line for filling and finishing a product
DE102014214697A1 (de) * 2014-07-25 2016-01-28 Robert Bosch Gmbh Vorrichtung zum Befüllen eines Behältnisses
ES2750816T3 (es) * 2015-06-11 2020-03-27 Ima Spa Método y máquina de llenado y sellado de frascos, cartuchos, jeringas y similares
US10246202B2 (en) * 2016-07-06 2019-04-02 Khs Gmbh Container-treatment machine
DE102017100010A1 (de) * 2017-01-02 2018-07-05 Groninger & Co. Gmbh Vorrichtung und Verfahren zum Befüllen genesteter Gebinde
DE102017207307A1 (de) * 2017-03-13 2018-09-13 Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG System mit alternierender Füllung von Behältern und Verfahren hierzu

Also Published As

Publication number Publication date
EP3931106B1 (fr) 2024-05-29
WO2020233881A1 (fr) 2020-11-26
DE102019207282A1 (de) 2020-11-19
CN113993787B (zh) 2024-03-08
CA3136505A1 (fr) 2020-11-26
CN113993787A (zh) 2022-01-28
US20220212818A1 (en) 2022-07-07

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