EP3917841A1 - Procédé et dispositif de fermeture stérile d'un récipient - Google Patents

Procédé et dispositif de fermeture stérile d'un récipient

Info

Publication number
EP3917841A1
EP3917841A1 EP20700884.8A EP20700884A EP3917841A1 EP 3917841 A1 EP3917841 A1 EP 3917841A1 EP 20700884 A EP20700884 A EP 20700884A EP 3917841 A1 EP3917841 A1 EP 3917841A1
Authority
EP
European Patent Office
Prior art keywords
cap
container
tongs
caps
lifting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20700884.8A
Other languages
German (de)
English (en)
Inventor
Harald Reber
Patrick Schösser
Marcus Schwarze
Wolfgang Emmert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Stroebel SE and Co KG
Original Assignee
Bausch and Stroebel Maschinenfabrik Ilshofen GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch and Stroebel Maschinenfabrik Ilshofen GmbH and Co KG filed Critical Bausch and Stroebel Maschinenfabrik Ilshofen GmbH and Co KG
Publication of EP3917841A1 publication Critical patent/EP3917841A1/fr
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • B65B7/2842—Securing closures on containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/46—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using grippers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B53/00—Shrinking wrappers, containers, or container covers during or after packaging
    • B65B53/02—Shrinking wrappers, containers, or container covers during or after packaging by heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/161—Sealing filled ampoules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D43/00—Lids or covers for rigid or semi-rigid containers
    • B65D43/02—Removable lids or covers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/003—Articles enclosed in rigid or semi-rigid containers, the whole being wrapped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/048—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical
    • B65D77/0486—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical the inner container being coaxially disposed within the outer container
    • B65D77/0493—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical the inner container being coaxially disposed within the outer container and retained at a distance of the inner side-wall of the outer container, e.g. within a bottle neck
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2220/00—Specific aspects of the packaging operation
    • B65B2220/16—Packaging contents into primary and secondary packaging

Definitions

  • the present invention relates to a method and an apparatus for sterile enclosing a container.
  • Vials, syringes or the like are generally used as containers.
  • a mechanical method and a corresponding device would be particularly advantageous in order to enclose a single corresponding container completely and in a sterile manner.
  • the object of the present invention is therefore to provide a corresponding method and a corresponding device.
  • the method according to the invention for sterile enclosing a container with at least two caps comprises at least the following steps: c) gripping a first area of the container, which is already provided with a first cap in the first area, with a first pair of tongs by gripping and clamping the first cap; and e) pushing a second cap onto a second area of the container which is not yet provided with one of the caps, so that the second cap abuts the first cap and / or the second cap slips over the first cap and / or the second cap from of the first cap and / or such that the first and the second cap have complementary threads and / or projections
  • ge / recesses and / or engagement means are connected and / or so that between the second cap and the first cap a sterile sealing connection to the outside of the caps is formed or can be formed, for example by leaving a bridgeable distance between the caps; and preferably h) connecting the first and the second cap in a preferably sterile sealing manner, preferably by sticking a sealing film and / or a label onto the first and the second cap, so that the sealing film and / or the label provide an intermediate and / or or gaps area between the first and second cap seals sterile.
  • the intermediate area is to be understood as the area which, when fitted with one cap on the other, lies between the end of one cap and the outer wall of the other cap.
  • the gap area is to be understood as the area between the ends of the cap when no cap is put over the other and possibly even a distance between the ends of the caps remains.
  • the gap area means both the distance that results when the first and second caps are not long enough to come into contact, and the area with a possibly narrow gap when the caps are just abutting or as far as possible the second cap is pushed on.
  • the connection in a preferably sterile sealing manner should preferably be understood to mean that this intermediate and / or gap area is sealed to such an extent that its permeability is almost equal to or equal to the permeability of the cap. is pen material.
  • adhesive materials, swelling materials and / or also thermal treatment and / or treatment with pressure can be considered for this purpose, the latter for example if the cap material of a cap can be brought to this by appropriate heat and / or pressure to connect to the cap material of the other cap or to glue it.
  • Step h) can also take place spatially separately in a product manufacturing process. So that steps c) and e) are carried out, for example, in a plant / at a production location, the container is then moved to another location - the container provided with the caps may still be suitable and preferably sterile packed for transport - and then is carried out in a further plant / on a further production step h).
  • the sealing film or the outside of the cap can be provided with corresponding application instructions, date of manufacture or quality and / or degree of contamination prevention.
  • the method according to the invention can also be used in cases in which no sterile sealing takes place after the caps have been put on. This is because there is still the advantage that maximum sterility is ensured at least at the time the caps are put on. So the maintenance of sterility depends only on the subsequent flaming of the container.
  • the method according to the invention can at least ensure that the containers for this further processing are provided in a sufficiently sterile manner and avoid cross-contamination.
  • the sealing film and / or the label can also be applied for reasons other than indicating that cross-contamination has been avoided, for example product information, security features or the like can be applied to it. For example, to show the user a certain manufacturing standard or to make it difficult to counterfeit products. However, this can of course also be combined with the fact that the sealing sequence and / or the label simultaneously indicate that cross contamination was avoided during filling.
  • Such properties can be recognized by a user in particular by whether the sealing film and / or the label are undamaged.
  • caps should overlap, should be pushed open until they meet, or whether there is a distance between the ends of the caps essentially depends on how large the corresponding tolerance ranges have to be based on the expected deviations / inaccuracies in cap size / shape, container size / shape and / or pliers shape / movement.
  • the most advantageous is usually a configuration in which there is a small distance between the two ends of the caps.
  • the method according to the invention preferably further comprises one or more of the steps: a) lifting the container from a first conveying means by means of lifting tongs which do not grip and / or clamp the container in the first area, the lifting tongs preferably gripping the container in the second area and / or stuck; b) pushing the first cap onto the first area; c) releasing the lifting tongs from the container and preferably removing the lifting tongs from the container; f) gripping the second region of the container with a second pair of pliers by gripping and clamping the second cap; i) depositing the container on a second conveyor; and / or x) moving the container by means of one of the tongs gripping and / or clamping tongs along a process path and / or to / from the first conveying means, the second conveying means, a first cap placement station and / or a second cap placement station as an intermediate step between two other steps.
  • none of the lifting tongs, first tongs, second tongs, first conveying means and / or second conveying means has contact with both an outside of the container and an outside of a cap in the course of the method.
  • first funding, second funding, lifting tongs, first tongs and second tongs do not necessarily have to be physically completely separate objects.
  • a total funding a first section of which corresponds to the first funding that comes into contact with the outside of the container, while a second section of the total funding corresponds to the second funding that only comes into contact with the outside of the Caps coming.
  • the lifting tongs, the first tongs and / or the second tongs can be part of the same transport rake comprising several tongs and / or in other embodiments the lifting tongs, the first tongs and / or the second tongs can be part of different ones Be a transport rake.
  • first and second pliers namely that corresponding sections of a transport rake and / or the same transport rake are included
  • Pliers that correspond to the first or second pliers are only used as first or second pliers in the sense of the method and do not come into contact with the outside of the container and only come into contact with the caps.
  • a first transport rake is used for the method, which includes lifting tongs in a first area and includes second tongs in a second area.
  • This first transport rake extends along one side of a total conveying means.
  • On the opposite side preferably extends a second transport rake, which generally comprises only half as many tongs, the tongs of which serve as the first tongs.
  • the transport rakes can also provide the propulsion along the conveying means, with the corresponding transfer from the lifting tongs to the first tongs of the opposite or second transport rakes, the containers are transported further by clamping the caps along the conveying direction, so that the second tongs accordingly of the first transport rake can clamp the container or the outside of the caps in the corresponding step.
  • the lifting tongs, the first tongs, the second tongs and / or a transport rake comprising the lifting tongs, the first tongs and / or the second tongs are preferably rotated away from the container before and / or after gripping / clamping the container and / or a cap.
  • This can be technically advantageous when implementing a specific machine be lateral movement, in particular if the turning away about an axis is parallel to a direction of longitudinal extension of the first conveying means, the second conveying means and / or the transport rake (s).
  • Transport rakes, lifting tongs, first tongs and / or second tongs are preferably movable along the conveying means.
  • the lifting tongs, the first tongs and / or the second tongs are preferably each formed by two jaws movable relative to one another, between which the container or the caps can be clamped.
  • the first and / or the second conveying means a conveyor belt, a combination of a transport surface and transport slides, transport rakes and / or a transport container, for example a tub or a nest, are preferred.
  • the container is preferably a vial, a syringe or a similar container that can be used for medical products.
  • the first and / or the second cap are preferably designed as a cylinder which is open on one side and preferably circular or rectangular with a diameter larger than a largest diameter of the container or in the first or in the second region.
  • the variant with cylinders open on one side is preferred, because then only the first and second cap have to be pushed on, if necessary, an intermediate area has to be sealed and the container is completely of the enclosed two caps and because of the sealed or isolating sealing connection between the two, the container is packaged in a sufficiently sterile manner.
  • This variant is particularly preferred since most of the corresponding loading containers are of such a simple shape that caps can simply be pushed onto a container from two directions.
  • an advantageous variant of the method according to the invention provides that only the first cap is designed as a cylinder that is open on one side and the second cap as a cylinder that is open on both sides the steps include: ey) pushing a further cap designed as a cylinder open on one or both sides onto a further area of the container which has not yet been provided with a cap, so that the further cap slips on the cap which was pushed on last and / or is slipped over by this cap and / or so that the further cap and the last cap pushed on previously via complementary threads and / or projections
  • ge / recesses and / or engagement means are connected and / or so that a sterile sealing connection to the outside of the caps is formed or can be formed between the further cap and the last previously pushed on cap, for example by a bridgeable distance between the caps remains; and hy) connecting the others and the ones previously deferred
  • Caps in a sterile sealing manner preferably by sticking a sealing film onto the other and the last one previously pushed on, so that the sealing film provides an intermediate and / or the gap area between the further cap and the cap which was pushed on last as a sterile seal, steps ey) and hy) preferably being carried out repeatedly after step h), at least one step ey) pushing on a cap designed as a cylinder open on one side includes before the last executed step ey).
  • the first cap is exposed as a cylinder open on one side at one end of a container and then second and further caps, which are designed as cylinders open on both sides, are pushed onto the container until the container is so is adequately covered with caps that a last cap, which is also formed as a cylinder that is only open on one side, can be pushed on and then the container is surrounded or enclosed by caps, if necessary, except for intermediate and / or gap areas that are still to be closed.
  • Corresponding pliers can be used between steps ey) and eh) according to step f) mentioned above.
  • the first and second pliers can also be designed such that they alternately clamp the successively placed further caps and move the container accordingly so that further caps can be pushed on.
  • the first, the second and / or further caps and / or the sealing film preferably comprise a plastic material and / or another easily moldable Material and / or walls which or which meet the sterility requirements of the sterility requirements of medical products contained or filled in the container.
  • a device according to the invention can be designed according to the technical features described above with regard to the method.
  • a configuration is particularly possible that does not include any means for carrying out step h). Because in appropriate systems for filling pharmaceutical products, labeling / sealing / packaging stations are often located in other systems / machines than the filling itself.
  • cap pen The avoidance of cross-contamination and provision of a sterile product provided with cap pen is still an advantageous property of the machine according to the invention, even if a user of the machine uses it in a system chain, in which, for example, the subsequent labeling or transport of the capped containers there is less sterile and / or does not completely avoid cross-contamination.
  • An advantage of an embodiment of the method according to the invention or the device / machine according to the invention without step h) or without means for this is also that the method according to the invention can then be used flexibly with regard to applications in which high importance is attached to sterility and avoidance of cross-contamination in Reference is made to the application of the label / sealing film, as well as with regard to application conditions where this is of minor importance. It is then not necessary to provide different devices for both cases.
  • a device according to the invention for performing a method according to the invention preferably comprises
  • At least one first cap placement station for pushing a first cap onto a container
  • At least one second cap placement station for pushing a second cap onto the container which is preferably fed with the first pliers or alternatively the first cap placement station is also laid out for pushing the second cap onto the container which is preferably handled with the first pliers;
  • At least one sealing device for the sterile sealing connection of the first and second cap or alternatively the first and / or the second cap fitting station are also designed for such a sterile sealing connection of the first and second cap.
  • the device according to the invention preferably further comprises:
  • At least one lifting tongs suitable for lifting the container from the conveying means and / or for feeding to the first cap placement station;
  • At least a second pair of pliers for gripping the container after pushing on the second cap by clamping the second cap pushed onto the container;
  • At least one second conveyor for further transport of the before supplied by the second pliers and with at least the first and the second cap coated container.
  • a device according to the invention can preferably also be designed such that several lifting clamps, first clamps or second clamps comprising transport rakes are provided in each case.
  • a transport rake comprising lifting tongs and second tongs is particularly suitable and a further transport rake opposite to be provided on the other side of a conveyor which comprises the first tongs.
  • the first cap, second cap and / or further caps are preferably not rigid. So in particular elastic and / or resilient to the extent that the caps give way to the clamping so far that the inside of the caps contacts the container at some points and thus the clamping force is transmitted to the container via the cap.
  • Figures 1 .1 -1 .15 show the implementation of a first embodiment of the method according to the invention using a device according to the invention in each case in a schematic view in the direction of view along the conveyor; and FIGS. 2.1 and 2.2 show the steps corresponding to FIGS. 1.8 and 1.10 of a second embodiment of the method according to the invention using the same device according to the invention as in FIGS. 1.1-1.15, but using different caps.
  • Figure 1 .1 shows the situation at the beginning of an embodiment of the inventive method using an embodiment of the inventive device.
  • the container (40) has been brought to the working area of the lifting tongs (14) by means of a first conveying means (10), which is part of the device according to the invention, but can also be separate therefrom.
  • the lifting tongs (14) are aligned with their mutually movable jaws (16, 18) on a second region (44) of the container (40).
  • the container (40) was raised by means of the lifting tongs (14) and removed from the first conveying means (10).
  • 1 .3 shows how the first cap (52) is lowered from the top of FIG. 1 .3 onto the first region (42) of the container (40) located at the top.
  • the cap (52) can be held on the tube (60) by means of a negative pressure during the lowering process.
  • the lowering process has ended, the suppression has ended, and the cap (52) thus remains on the now covered first area (42) of the container (40).
  • the cap (52) is dimensioned and the attachment point of the lifting tongs (14) is selected so that there is no contact between the first cap pe (52) and the lifting tongs (14) and their jaws (16, 18).
  • Figures 1.5 and 1.6 show how the first pliers (22) are brought up and the first cap (52) with the help of their similar to the jaws (16, 18) of the lifting tongs (14) constructed jaws.
  • the first pliers (22) now clamp the container (40), and only by contacting the cap (52) and without contact with the actual body of the container (40).
  • FIGS. 1.7 and 1.8 show how the lifting tongs (14) are subsequently removed from the container (40) and how the container (40) is moved with the aid of the first tongs (22) relative to the first conveyor means (10), which is designed, for example, as a conveyor belt, so that in a similar way as before, the first cap (52) was fed from above with the help of the tube (62), the second cap (54) from below to the container (40) and directed towards the second area (44 ) can be introduced.
  • the first conveyor means (10) which is designed, for example, as a conveyor belt
  • the cap (54) has an engagement means (56) on the outside, which can interact with a complementary engagement means on the inside or on the inner circumference of the cap (52).
  • the engagement means (56) can be, for example, an annular projection.
  • the second cap (54) Since the diameter of the second cap (54) is slightly smaller than the diameter of the first cap (52), the second cap (54) is slipped over by the first cap (52) and the engagement means (56) engage in one another.
  • the second pliers (24) are brought up to clamp the second cap (54), as a result of which the container (40), which is now completely covered by the two caps (52, 54), is moved by the second pliers (24) can be held.
  • the setting tube (62) is now moved down.
  • the first pliers (22) are removed from the cap (52) and moved away.
  • FIG. 1.11 shows how the sealing film (58) is now pushed over the first cap (52) from above with the aid of the setting ring (59) until the state shown in FIG. 1.12 is reached that the sealing film (58) exactly the over Corridor area or gap area between the first cap (52) and the second cap (54) covered.
  • the sealing film (58) is pressed onto the two caps (52, 54) with the aid of the setting ring (59) and glued to them in a sterile, sealing manner, for example by heat.
  • the sealing film or a label can also be applied to the gap area by unrolling. Both a movement of a corresponding rolling device around the container and a rotation of the container and / or a combination of both is conceivable for this.
  • the container may have to be moved onto a turntable or the like using the second pair of pliers.
  • the application of the sealing film can also be omitted at this point and the provision of means for this, such as the setting ring (59) or unrolling devices, can be dispensed with.
  • the sealing film can, for example, also be applied subsequently using another machine.
  • FIGS. 1.13 to 1.15 it is now shown how the setting ring (59) is moved up again and with the aid of the second pliers (24) the completely covered container (40) in a second conveying means (12), here for example a trough of a nest that is set down.
  • a second conveying means (12) here for example a trough of a nest that is set down.
  • the caps are dimensioned such that they are slipped on. In other embodiments, however, the caps can also be dimensioned such that they have an almost identical diameter and the two ends of the caps come into contact or there is a certain distance between the cap ends after the attachment, which is then bridged, for example, by the sealing film.
  • FIGS. 2.1 and 2.2 show such a case of using caps 52, 54 of different dimensions, with the caps also shown in FIGS. showed machine.
  • Figure 2.1 corresponds to Figure 1.8
  • Figure 2.2 corresponds to Figure 1.10.
  • the first cap 52 is of the same design, but the second cap 54 is of less length and has a diameter similar to that of the first.
  • caps 52, 54 are already connected in the contact area by pressure and / or flashing, preferably in a sterile sealing manner.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closing Of Containers (AREA)

Abstract

L'invention concerne un procédé de fermeture stérile d'un récipient (40) comportant au moins deux capuchons (52, 54), le procédé comprenant les étapes suivantes, de préférence dans l'ordre alphabétique, consistant : c) à saisir, à l'aide d'une première pince (22), une première zone (42) du récipient (40) qui est déjà pourvue d'un premier capuchon (52) dans la première zone (42), par saisie et serrage du premier capuchon (52) ; et e) à faire coulisser le second capuchon (54) sur une seconde zone (44) du récipient (40) qui n'est pas encore pourvue de l'un des capuchons (52, 54), de façon à ce que le second capuchon (54) recouvre le premier capuchon (52) et/ou soit recouvert par le premier capuchon (52), et/ou à ce que les premier et second capuchons (52, 54) soient reliés par l'intermédiaire de filetages complémentaires et/ou de saillies/d'évidements (56) et/ou de moyens de mise en prise (56), et/ou à ce que, entre le second capuchon (54) et le premier capuchon (52), une liaison assurant une étanchéité stérile vers la face externe des capuchons soit réalisée ou puisse être réalisée ; et de préférence h) à relier les premier et second capuchons (52, 54) à étanchéité stérile, de préférence par collage d'un film de scellement (58) sur les premier et second capuchons (52, 54), de façon à ce que le film de scellement étanchéifie stérilement une zone intermédiaire et/ou de vide située entre les premier et second capuchons (52, 54).
EP20700884.8A 2019-01-28 2020-01-14 Procédé et dispositif de fermeture stérile d'un récipient Pending EP3917841A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102019201028.8A DE102019201028A1 (de) 2019-01-28 2019-01-28 Verfahren und Vorrichtung zum sterilen Umschließen eines Behälters
PCT/EP2020/050817 WO2020156803A1 (fr) 2019-01-28 2020-01-14 Procédé et dispositif de fermeture stérile d'un récipient

Publications (1)

Publication Number Publication Date
EP3917841A1 true EP3917841A1 (fr) 2021-12-08

Family

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Family Applications (1)

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EP20700884.8A Pending EP3917841A1 (fr) 2019-01-28 2020-01-14 Procédé et dispositif de fermeture stérile d'un récipient

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US (1) US20220097879A1 (fr)
EP (1) EP3917841A1 (fr)
CN (1) CN113272226B (fr)
DE (1) DE102019201028A1 (fr)
WO (1) WO2020156803A1 (fr)

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AU671478B2 (en) * 1992-08-19 1996-08-29 British Nuclear Fuels Plc Apparatus for dispensing substances which are biologically hazardous
US6189292B1 (en) * 1998-03-13 2001-02-20 Becton Dickinson And Company Method and apparatus for manufacturing, filling and packaging medical devices and medical containers
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CA2607449C (fr) * 2005-05-16 2014-11-25 Intelligent Hospital Systems Ltd. Systeme de melange automatise de produits pharmaceutiques
ATE441582T1 (de) * 2006-09-25 2009-09-15 Mettler Toledo Ag Dosiervorrichtung für pulver- oder pastenfírmiges dosiergut
EP2140236A1 (fr) * 2007-04-10 2010-01-06 Mettler-Toledo AG Unité récipient destinée à la conservation et à la protection de substances de laboratoire
PE20151989A1 (es) * 2013-05-30 2016-01-20 Dalwick Continental Corp Metodo para la fabricacion de envases de vidrio para uso farmaceutico
DE102013114896B4 (de) * 2013-12-27 2015-08-27 Schott Ag Verpackungsstruktur und Verfahren zur sterilen Verpackung von Behältern für Substanzen für medizinische, pharmazeutische oder kosmetische Anwendungen sowie Verfahren zur Weiterverarbeitung von Behältern unter Verwendung der Verpackungsstruktur
RU2620979C2 (ru) * 2014-09-16 2017-05-30 Бреветти Анджела С.Р.Л. Способ изготовления контейнера
US10206852B2 (en) * 2014-12-18 2019-02-19 Orbit Biomedical Limited Vial holder devices and systems

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WO2020156803A1 (fr) 2020-08-06
US20220097879A1 (en) 2022-03-31
CN113272226A (zh) 2021-08-17
CN113272226B (zh) 2022-09-02
DE102019201028A1 (de) 2020-07-30

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