EP3813687A4 - Pharmazeutische zusammensetzungen und verfahren zur behandlung von thrombosen und verabreichung durch medizinische vorrichtungen - Google Patents

Pharmazeutische zusammensetzungen und verfahren zur behandlung von thrombosen und verabreichung durch medizinische vorrichtungen Download PDF

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Publication number
EP3813687A4
EP3813687A4 EP19824845.2A EP19824845A EP3813687A4 EP 3813687 A4 EP3813687 A4 EP 3813687A4 EP 19824845 A EP19824845 A EP 19824845A EP 3813687 A4 EP3813687 A4 EP 3813687A4
Authority
EP
European Patent Office
Prior art keywords
thrombosis
delivery
treatment
methods
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19824845.2A
Other languages
English (en)
French (fr)
Other versions
EP3813687A1 (de
Inventor
Michael K. HANDLEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marizyme Inc
Original Assignee
Marizyme Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marizyme Biotech filed Critical Marizyme Biotech
Publication of EP3813687A1 publication Critical patent/EP3813687A1/de
Publication of EP3813687A4 publication Critical patent/EP3813687A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4806—Hydrolases (3) acting on peptide bonds (3.4) from animals other than mammals, e.g. snakes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21004—Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12036—Type of occlusion partial occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/1204—Type of occlusion temporary occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP19824845.2A 2018-06-28 2019-06-28 Pharmazeutische zusammensetzungen und verfahren zur behandlung von thrombosen und verabreichung durch medizinische vorrichtungen Withdrawn EP3813687A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862691319P 2018-06-28 2018-06-28
PCT/US2019/039878 WO2020006444A1 (en) 2018-06-28 2019-06-28 Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices

Publications (2)

Publication Number Publication Date
EP3813687A1 EP3813687A1 (de) 2021-05-05
EP3813687A4 true EP3813687A4 (de) 2022-03-23

Family

ID=68985200

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19824845.2A Withdrawn EP3813687A4 (de) 2018-06-28 2019-06-28 Pharmazeutische zusammensetzungen und verfahren zur behandlung von thrombosen und verabreichung durch medizinische vorrichtungen

Country Status (9)

Country Link
EP (1) EP3813687A4 (de)
JP (1) JP2022525713A (de)
CN (1) CN112638289A (de)
AU (1) AU2019292557A1 (de)
BR (1) BR112021004809A2 (de)
CA (1) CA3110779A1 (de)
CR (1) CR20210059A (de)
EA (1) EA202190494A1 (de)
WO (1) WO2020006444A1 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170115A1 (de) * 1984-07-20 1986-02-05 Kao Corporation Auflösungsmittel für Thrombus
WO2007080515A1 (en) * 2006-01-13 2007-07-19 Aker Biomarine Asa Thrombosis preventing krill extract

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7278094A (en) * 1994-06-07 1996-01-04 M D Serv Europe S.A. Intravasal thrombolysis
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
FR2797768B1 (fr) * 1999-09-01 2003-06-13 Ifremer Utilisation d'un polysaccharide sulfate de bas poids moleculaire pour l'obtention d'un medicament actif contre la thrombose vasculaire
US20040241249A1 (en) * 2001-06-18 2004-12-02 Tina Sampalis Krill and/or marine extracts for prevention and/or treatment of cardiovascular diseases arthritis, skin cancer diabetes, premenstrual syndrome and transdermal transport
CN1327893C (zh) * 2001-10-01 2007-07-25 布雷德利 胶原酶在促进导线在完全动脉闭塞内通过中的应用
CN1210036C (zh) * 2002-06-18 2005-07-13 蚌埠丰原医药科技发展有限公司 赖氨匹林的新用途
SE0303588D0 (sv) * 2003-12-30 2003-12-30 Bioactive Polymers Ab C O Lund Surface protection of exposed biological tissues
JP4677557B2 (ja) * 2005-05-11 2011-04-27 国立大学法人東北大学 超音波プローブ及びそれを用いたカテーテル並びにその製造方法
EP1726301A1 (de) * 2005-05-24 2006-11-29 Flamel Technologies Pharmazeutische Zusammensetzung zur Behandlung COX-2 vermittelter Krankheiten
DE102005042338B4 (de) * 2005-09-06 2007-07-05 Siemens Ag Kathetereinrichtung
US20130287757A1 (en) * 2011-01-13 2013-10-31 Medestea Internazionale S.P.A. Composition for the regeneration of atrophic tissues
EP3071125B1 (de) * 2013-11-18 2021-08-04 Koninklijke Philips N.V. Vorrichtungen zur thrombenstreuung
DE202015002060U1 (de) * 2015-03-17 2015-11-25 Gerhard-Friedrich Horak Infusions- und Aspirations- Catheter (IAC) (Katheter zur Entfernung von Thromben und Applikation von Medikamenten)
US10973681B2 (en) * 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
EP3554611A1 (de) * 2016-12-13 2019-10-23 Boston Scientific Scimed Inc. Thrombolysekathetersystem

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170115A1 (de) * 1984-07-20 1986-02-05 Kao Corporation Auflösungsmittel für Thrombus
WO2007080515A1 (en) * 2006-01-13 2007-07-19 Aker Biomarine Asa Thrombosis preventing krill extract

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SJODAHL JOHAN ET AL: "Characterization of proteinases from Antarctic krill (Euphausia superba)", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 26, no. 1, 1 October 2002 (2002-10-01), pages 153 - 161, XP002359070, ISSN: 1046-5928, DOI: 10.1016/S1046-5928(02)00519-3 *

Also Published As

Publication number Publication date
EP3813687A1 (de) 2021-05-05
WO2020006444A1 (en) 2020-01-02
BR112021004809A2 (pt) 2021-06-22
CN112638289A (zh) 2021-04-09
CA3110779A1 (en) 2020-01-02
JP2022525713A (ja) 2022-05-19
EA202190494A1 (ru) 2021-12-09
CR20210059A (es) 2021-12-23
AU2019292557A1 (en) 2021-04-01

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