CR20210059A - Composiciones farmacéuticas y métodos para el tratamientos de la trombosis y administración a través de dispositivos médicos - Google Patents

Composiciones farmacéuticas y métodos para el tratamientos de la trombosis y administración a través de dispositivos médicos

Info

Publication number
CR20210059A
CR20210059A CR20210059A CR20210059A CR20210059A CR 20210059 A CR20210059 A CR 20210059A CR 20210059 A CR20210059 A CR 20210059A CR 20210059 A CR20210059 A CR 20210059A CR 20210059 A CR20210059 A CR 20210059A
Authority
CR
Costa Rica
Prior art keywords
pharmaceutical composition
thrombosis
treatment
delivery
methods
Prior art date
Application number
CR20210059A
Other languages
English (en)
Inventor
Michael K Handley
Original Assignee
Marizyme Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marizyme Biotech filed Critical Marizyme Biotech
Publication of CR20210059A publication Critical patent/CR20210059A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4806—Hydrolases (3) acting on peptide bonds (3.4) from animals other than mammals, e.g. snakes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21004—Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12036—Type of occlusion partial occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/1204—Type of occlusion temporary occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Se proporcionan una composición farmacéutica y un método para el uso de la composición farmacéutica para el tratamiento de la trombosis. La composición farmacéutica puede incluir una mezcla de enzimas proteolíticas y, opcionalmente, compuestos adicionales. La composición farmacéutica puede incluir un compuesto antiagregante o antitrombótico, tal como Lisini racemici acetylsalicylase. El método puede incluir administrar la composición farmacéutica a un paciente que lo necesita, lo que incluye la administración de la composición farmacéutica a un trombo hasta que se disuelva el trombo. El método también puede incluir administrar uno o más catéteres con globo al paciente
CR20210059A 2018-06-28 2019-06-28 Composiciones farmacéuticas y métodos para el tratamientos de la trombosis y administración a través de dispositivos médicos CR20210059A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862691319P 2018-06-28 2018-06-28
PCT/US2019/039878 WO2020006444A1 (en) 2018-06-28 2019-06-28 Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices

Publications (1)

Publication Number Publication Date
CR20210059A true CR20210059A (es) 2021-12-23

Family

ID=68985200

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210059A CR20210059A (es) 2018-06-28 2019-06-28 Composiciones farmacéuticas y métodos para el tratamientos de la trombosis y administración a través de dispositivos médicos

Country Status (9)

Country Link
EP (1) EP3813687A4 (es)
JP (1) JP2022525713A (es)
CN (1) CN112638289A (es)
AU (1) AU2019292557A1 (es)
BR (1) BR112021004809A2 (es)
CA (1) CA3110779A1 (es)
CR (1) CR20210059A (es)
EA (1) EA202190494A1 (es)
WO (1) WO2020006444A1 (es)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6130527A (ja) * 1984-07-20 1986-02-12 Kao Corp 血栓溶解剤
WO1995033471A1 (en) * 1994-06-07 1995-12-14 Hellgren, Lars Intravasal thrombolysis
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
FR2797768B1 (fr) * 1999-09-01 2003-06-13 Ifremer Utilisation d'un polysaccharide sulfate de bas poids moleculaire pour l'obtention d'un medicament actif contre la thrombose vasculaire
DK1997498T3 (da) * 2001-06-18 2012-07-30 Neptune Technologies & Bioressources Inc Krillekstrakter til forebyggelse og/eller behandling af kardiovaskulære sygdomme
IL161137A0 (en) * 2001-10-01 2004-08-31 Bradley H Strauss Use of a formulation containing collagenase for degrading collagen in occluded arteries
CN1210036C (zh) * 2002-06-18 2005-07-13 蚌埠丰原医药科技发展有限公司 赖氨匹林的新用途
SE0303588D0 (sv) * 2003-12-30 2003-12-30 Bioactive Polymers Ab C O Lund Surface protection of exposed biological tissues
JP4677557B2 (ja) * 2005-05-11 2011-04-27 国立大学法人東北大学 超音波プローブ及びそれを用いたカテーテル並びにその製造方法
EP1726301A1 (en) * 2005-05-24 2006-11-29 Flamel Technologies Oral pharmaceutical composition for treating a COX-2 mediated condition
DE102005042338B4 (de) * 2005-09-06 2007-07-05 Siemens Ag Kathetereinrichtung
WO2007080515A1 (en) * 2006-01-13 2007-07-19 Aker Biomarine Asa Thrombosis preventing krill extract
WO2012095702A1 (en) * 2011-01-13 2012-07-19 Medestea Internazionale S.P.A. A composition for the regeneration of atrophic tissues
JP2017502715A (ja) * 2013-11-18 2017-01-26 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 血栓分散方法及び装置
DE202015002060U1 (de) * 2015-03-17 2015-11-25 Gerhard-Friedrich Horak Infusions- und Aspirations- Catheter (IAC) (Katheter zur Entfernung von Thromben und Applikation von Medikamenten)
CN110177527B (zh) * 2016-08-12 2022-02-01 科尼尔赛德生物医学公司 用于调节药剂递送用针的插入深度的装置和方法
EP3554611A1 (en) * 2016-12-13 2019-10-23 Boston Scientific Scimed Inc. Thrombolysis catheter system

Also Published As

Publication number Publication date
BR112021004809A2 (pt) 2021-06-22
JP2022525713A (ja) 2022-05-19
CA3110779A1 (en) 2020-01-02
CN112638289A (zh) 2021-04-09
EP3813687A1 (en) 2021-05-05
AU2019292557A1 (en) 2021-04-01
WO2020006444A1 (en) 2020-01-02
EA202190494A1 (ru) 2021-12-09
EP3813687A4 (en) 2022-03-23

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