EP3720775A1

EP3720775A1 - Apparatus and system for blister-packaging medicinal products and method for operating same

Info

Publication number: EP3720775A1
Application number: EP18847234.4A
Authority: EP
Inventors: Lydia Six; Josef Artmann
Original assignee: As Medicals GmbH
Current assignee: As-Medicals GmbH
Priority date: 2017-12-04
Filing date: 2018-11-29
Publication date: 2020-10-14
Also published as: WO2019110047A1

Abstract

The invention relates to an apparatus (1) for blister-packaging medicinal products, in particular medicinal products that are individual to patients, said apparatus having: a supply store (2) for a plurality of different medicinal products, transport containers (10) for an individual combination of medicinal products, a transport system (12) for the transport containers (10), wherein the supply store (2) comprises a plurality of supply containers (3) which can be arranged statically on a storage frame (21) and can each be filled with individual medicinal products, the transport system (12) comprises at least one pathway (13-19) and the transport containers (10) can be moved successively in the at least one pathway (13-19) by means of the transport system (12) to below or next to each individual supply container (3) so that by means of gravity one or more separate medicinal products can each be fed to a transport container (10) from previously defined supply containers (3), and comprising a transfer station (40) for transferring the individual combination of medicinal products from the transport container (10) to a machine for individually packaging the combination of medicinal products.

Description

Device and system for drug blinding and

Method of operating for it

DESCRIPTION

background

Here, an apparatus and a system for a blistering of, in particular patient-specific, medicaments with a storage container for a multiplicity of different medicaments, with transport containers for an individual composition of medicaments and with a transport system for the transport containers are described. Likewise, a method for operating the device and the system, and a computer program product are described.

PRIOR ART WO 2013/0345404 describes a system for packaging metered quantities of solid medicament portions. The system has a large number of dosing stations, which are arranged in groups on one vertical guide channel each. Each guide channel is assigned a collecting container. The collection containers transfer the collected medication portions to a packing station. The medicine portions are packed in a vending machine either individually or together and form the metered amount. The vertical guide channels have inclined deflections with a maximum distance of 200mm, so that a fall height of the drugs is limited to a maximum of 200mm. This is intended to prevent bursting or damaging of the medicaments, since a larger amount of superimposed metering stations must be returned as a group from the medicaments to the collecting container. Another system for packaging metered amounts of drugs is known, in which the metering stations are arranged in a circle over several levels on a funnel. The funnel forms a central guide channel for the drugs from the dosing stations. At the funnel end a collection container is arranged, which feeds the collected drugs to a packaging machine.

In general, systems for packaging metered amounts of drugs have a common downcomer on which a plurality of metering stations are arranged in multiple levels and over which the metered quantities are fed to a collection container.

Problem to be solved

The aim is to create a device and a system, as well as a procedure and a computer program product, so that an error rate of packaging of metered amounts of individually composed medicaments is significantly reduced and the degree of purity of the assembled medicaments is improved.

Solution benefits and design

In a device described here for the blinding of, in particular patient-specific, medicaments, the supply store can fill a large number of reservoirs, which can be arranged statically on a storage stand, with respective individual medicaments. The transport system comprises at least one passage and the transport containers are successively movable in the at least one passage below or next to each individual storage container by means of the transport system, so that one or more separated medicaments can be fed by gravity to a transport container from previously defined storage containers are. At a transfer station, a transfer of the individual compilation of medicaments from the transport container to a machine for individual packaging of the composition of medicaments takes place. The packaging of the individual composition of medicinal products is called blinding. The packaging can be individually printed with recipient data and content data as well as a transmission protocol. One idea is therefore to transfer the drugs directly to a transport container and to omit a common guide channel or a common guide tube. This has many advantages, so that conventional contaminants from various drugs that occur in the conventional, common guide channel, for example, by popping or flaking various drugs and then being taken up by other drugs, can not be put into individual composition should be essentially ruled out.

Also, an incorrect composition of medicines can be more easily excluded if, for example, the medicaments hang or adhere to the conventional guide channel and are later released by another medicament for a different composition and, instead, medicines stuck in the guide channel instead or transport container is supplied as instead of the desired drug. In the worst case, the conventional system does not recognize such confusion at all.

It is understood that each individual storage container at a Versohl ussöff- tion may have its own guide channel for better dissipation of drugs to the receiving opening of a transport container.

In order to provide the highest possible number of different drugs in different storage containers with a compact space requirement, the transport system comprises at least two gears formed one above the other and the storage containers are arranged statically arranged over the at least two aisles, wherein the courses in the plan view as a circle , Further preferably formed as a slot circle and the transport system is further preferably designed as a continuous rail.

The passages of the transport system have a slope at the Kreisabschnit- in a preferred embodiment, to promote the transport containers in the superimposed passages. Thus, an endless conveyor system can be realized. The reservoir can be distributed over the slope and arranged statically at the circular sections. This significantly reduces the space requirement and increases the number of possible different drugs. Alternatively, the transport system comprises a lift system with the transport containers are conveyed in the superimposed passages. In order to ensure a continuous conveyance of the transport containers, a conveying elevator may preferably be provided. A screw conveyor system for the transport containers has the transport system in the case of, for example, a circular supply store.

In accordance with a further embodiment, each storage container has a closure opening which can be actuated by means of an actuator, in particular by means of a servomotor, in order to dispense with gravity the medicament for transfer to the transport container. The transport container has an opening, which is formed in particular in a funnel shape and has a bottom, wherein the height of fall of the medicaments from the closure opening to the bottom is at most approximately 200 mm, preferably at most approximately 150 mm, more preferably at most 80 mm. This prevents medicines from bursting or bursting due to excessive drop height.

More preferably, the device is formed with a cleaning station in the conveying path of the transport container. In particular, the cleaning station is a device with a brush and a suction device is formed. The cleaning station is further preferably designed with a particle filter for separating suspended particles from the air, the transport containers (preferably being turned reversibly by the transport system for cleaning in the cleaning station at least to the side, more preferably turned downwards by 180 °. Thus, the purity of each combination of drugs is significantly increased since the assembly is fed into cleaned transport containers, so contamination of drugs from a previous composition should no longer occur.

The transport system has a linear guide track, in which a conveyor belt runs, and the transfer station is designed as a 360 ° turning section perpendicular to the transport direction by means of the linear guide track. Thus, a transfer of the collected medicaments is continuously and inexpensively realized.

A system is described with a device for a blistering of medicaments, in particular patient-specific, described above, the system having a central computer which transmits the transport containers, which can be marked by means of a first marking system, over the container Moving controls system that controls the actuators of the markable by means of a second marking system reservoir and which in each case with at least one sensor of the marked reservoir, in particular and / or the transport container, via a data communication system is connected. The first marking system is a conventional marking system known from the prior art, which preferably comprises a known radio wave identification system (RFID). The storage containers can be arranged, for example, in an orderly storage store, so that the computer is assigned to each storage location an individual defined drug in a defined storage container. This can be a second marking system. The system has the advantage that combinations of medicines with a high degree of purity and a significantly reduced error rate can be automated and efficient.

In order to enable a so-called chaotic sorted warehouse, the storage bins in the storage warehouse on the storage tower are marked with a third marking system and the bins are in electronic contact with the computer in data contact. If a certain storage space is now occupied by a storage container with the second marking system, the marked storage container with a special drug is assigned to the specific storage location in the computer. The second marking system is also a conventional marking system known in the art. For example, it may again comprise a radio-wave indication system (RFID technology). Thus, a marked storage container with a certain drug can be used at any free storage space in the storage warehouse and the computer recognizes the previously determined drug at the new storage location.

According to a further developing system, sensors and actuators of the storage containers and at least one of the marking systems are connected to a data bus system and these are connected to the computer for data exchange and control. By means of a data bus system, the cabling effort is significantly reduced. The first marking system more preferably comprises a safety system in order to check the marked transport container for correctness of the marking and position in the transport system at least once during the run. Thus, the error rate is reduced to collect a wrong composition of drugs.

So that the system has an even lower error rate is at each Reservoir designed a recognition system as a security system of the first Marking system, which is in data communication with the computer. More preferably, the detection system is formed on each storage container as an electronic reading and / or data transmission or writing device, with the at least one defined position and a marker, in particular with RFID technology, the transport container readable and transmitted to the computer is. Thus, the quota of a proper compilation of medicines is significantly increased and ensured.

More preferably, the system is provided with a station for sorting out defective compositions of drugs in front of the transfer station, thus more effectively preventing erroneous compilations of drugs from being packaged. The erroneous combination of drugs is preferably recognized by the computer during the transport process with the method described below.

The invention relates to a method for operating a device for the individual compilation of medicaments, having a device, in particular explained above, wherein the device comprises a storage rack with a carrier framework, into which reservoirs which can be arranged in a static manner are filled with individual medicaments , A transport system is provided for transporting medicaments in transport containers in at least one passage, whereby each transport container is successively moved under or next to each storage container, so that one or more separated medicaments are respectively fed to a transport container from predefined storage containers by gravity and at one Transferring the individual collection of drugs from the transport container to a machine for individual packaging. Thus, the degree of purity is markedly increased, since guide channels can only be designed for a specific individual medicament on a defined storage container and the common guide channels according to the prior art are dispensed with.

It describes a method for operating a system shown above, wherein the transport containers are marked by or with a first marking system and / or defined with respect to their transport position and / or the identified transport position is transmitted to the computer, the reservoir with a second marking system marked and identified in the storage warehouse with respect to a storage location and the an assigned order storage position is transmitted to the computer, an order for the compilation of drugs is received by the computer, the order is assigned a defined transport container and defined storage containers are determined for later drug transfer, wherein an actuator for actuating the closure opening and separated drug delivery the defined storage container is driven, as soon as the defined transport container was transported under or next to the previously defined corresponding reservoir for the transfer of separated drugs, the transfer by means of an optical sensor, in particular on the transport container or more preferably to the reservoir, is detected and transmitted to the computer and at the end of the transport route the compilation of the medicaments is transferred to the automatic blistering machine. Thus, the quality of the composition is improved, since a likelihood of confusion of the drug is better excluded.

In order to increase the quality of the compilation, the method comprises a safety system with identification sensors on the defined storage container, which is provided for the transfer of medicaments to a defined transport container. The defined transport container is identified according to the method, in particular by means of Radio Frequency Identification RFID technology, and this identification is transmitted to the computer.

A further step of a further process is that for each order a tracking protocol is created from each transfer of a drug from an identified storage container to an identified transport container in the computer. Thus, the quality of the compilation can be proved and documented with great precision.

In order to clearly and obviously improve the proof of the compilation in the form of a further quality feature, according to a continuing procedure in the automatic blister machine, a photo is taken by means of a camera from the compilation of the medicaments, transmitted to the computer and communicated to the order added to the tracking protocol, and stored in particular in an external data archive.

According to a further developing method, each transport container is assigned an electronic order list for the compilation of medicaments, at each storage container a read and write or Data transfer system arranged by means of which the first mark, and in particular the electronic job list is read when passing through the transport container, the actuator of a specific reservoir for separate drug transfer, in particular actively decentralized, should be indicated by the order list, a specific drug requirement and a transfer of the drug is written in the order list, a transfer should be recognized by the specific optical sensor, in particular at the station for sorting, the order list is checked for errors and in the negative case, the composition from the transport container the transfer is emptied to the blistering machine. The order list is centrally managed by the computer according to a first variant of the method and in each of these the fulfillment of the supply of specific drugs is recorded.

According to an alternative method, the order list can be arranged locally on each transport container and entered into the local order list, the fulfillment of the respective order of reading and writing or data transmission system of the specific storage container. This reduces the data transfer to the centrally located computer.

A computer program product with program code means is described for carrying out a method explained above when the computer program product runs on a computer and / or is stored in a storage medium. Thus, resource-saving with standardized components, a method explained above is realized efficiently.

Brief description of the drawings

Possible embodiments will now be explained in more detail with reference to the attached schematic diagrams, of which show:

Fig. 1 is a schematic representation of a preferred apparatus and a preferred system;

Fig. 2. shows a flow of the method of the device and the system; Fig.3-7 different views of the transport system of the device and

Fig. 8 is a plan view of another embodiment of the device.

Detailed description of the drawings

FIG. 1 shows a device 1 for a blistering of, in particular patient-specific, medicaments with a storage store 2 for a multiplicity of different medicaments. The various drugs are arranged successively in a plurality of individual storage containers 3 on a storage frame 21 side by side and, in the illustrated embodiment of Figure 1 on seven levels, one above the other and each filled with different drugs. The storage containers 3 form seven passages 13-19 on the different levels of the storage stand 21. The bearing frame 21 is formed in the plan view as a slot. In order to simplify the illustration of the device 1, the storage containers 3 are shown only at a vertex of a semicircle from the storage store 2, arranged on the right in FIG. 1, via the seven-aisles 13-19.

Each storage container 3 has an actuator 4 in the form of a servo motor in order to separate the drugs into individual pieces and deliver them in a defined manner. Each storage container 3 comprises at a closure opening 5 nen, in particular optical, sensor 6, with which the delivery of a separated drug is detected. The optical sensor 6 is, for example, a light barrier, which is interrupted when a separated drug falls through. It is understood that preferably the light barrier is only activated when the actuator 4 is in operation or has been recently. Each storage container 3 has an individual identification mark 7 by means of a second marking system, which comprises, for example, a radio wave identification system known from the prior art, RFID transponder system. This individual identification mark 7 is assigned a specific drug. The optical sensor 6 is arranged in a guide channel 8.

The device 1 comprises a plurality of transport containers 10 with a Funnel opening 9. Each transport container 10 is equipped with a transport container identification mark 1 1 of a first marking system. The first marking system can also be a known radio wave identification system, RFID transponder system. The transport containers 10 each collect an individual compilation of medicaments in the device 1 in order to deliver them at a transfer station 40 to an automatic machine 60 for individual packaging of the compilation of medicaments. The automaton 60 comprises a packaging machine 61, which welds the assembly into a plastic bag and prints it with receiver data, as well as a camera 61 for quality assurance of the composition of the medicaments of the plastic bags and a winding device 62 for winding up the plastic bag.

The transport containers 10 are conveyed by a transport system 12 through the storage warehouse 2. The transport system 12 is a system known from the prior art and can be any transport system 12 that realizes the kinematics of the transport containers 10 described below and above. Each transport container 10 is successively moved by the transport system 12 under each guide channel 8 from each individual storage container 3 through each passage 13-19 of the stocker 2. To transport system 12 includes a conveyor elevator 23 to promote the transport container 10 from one gear to the next gear. Alternatively, the next course may be in the form of a screw.

The distance between a closure opening 5 and a bottom 24 of each transport container 10 is preferably at most 100 mm. This reliably prevents the medicaments from bursting or flaking off if the medicaments are fed by gravity to a transport container 10 from previously defined storage containers 3.

The device 1 has a cleaning station 30 in the conveying path of the transport system 12. The cleaning station 30 comprises a device with a brush 31 and a suction device 32 with a suspended matter filter for the separation of suspended matter from the air. The transport containers 10 are at least turned sideways for cleaning in the cleaning station 30. Alternatively or additionally, which is not shown in Fig. 1, the bottom 24 is rotated downwards by 180 °.

Fig. 1 also shows a system 100 with a device 1 and a Computer 20 as a control of the system for carrying out the method described for Fig. 2 for an individual compilation of drugs. The computer 20 is designed for data exchange and for the control and regulation of the transport system 12, as well as the individual storage container 3 with a real-time capable data bus system 22 according to the prior art. This real-time data bus system 22 may be, for example, an Ethernet bus with protocols according to the prior art.

The system 100 controls the transport containers 10 which can be marked by means of the first marking system via the transport system 12, wherein at least one synchronization point 25 is provided as a security system of the first marking system in the transport system 12 with the transport containers 10. The actuators 4 of the storage container 3 which can be marked by means of the second marking system and the respectively at least one sensor of the marked storage container 3 are connected to the computer 20 by the data bus system 22 as data communication system.

The storage bins 26n in the storage warehouse 2 on the storage stand 21 are marked with a third marking system, which are considered to be stationary. These storage bins are in electronic contact with the computer 20 in data contact. Thus, it is precisely known to the computer 20 at which storage location 26 n which drug is located in a storage container 3.

As a refined safety system of the first marking system, the system 100 has arranged on each storage container 3 a recognition system which is in data communication with the computer 20 via the data bus system 22. In the system 100, an electronic reading and / or data transmission or writing device is formed on each storage container 3 as a recognition system, with which at least one defined position and a mark, in particular with RFID technology, of the transport container 10 can be read and can be transmitted to the computer 20. Thus, a position-accurate tracking protocol for each transport container 10 in the computer 20 can be created.

The system 100 is additionally provided with a station 50 for sorting out defective assortments of drugs in front of the transfer station 40, which is supported by a camera 51 for better control and verification of the erroneous composition. The station 50 is also connected to the data bus system 22 and is controlled by the computer 20. FIG. 2 shows a diagram of a sequence of a method for operating the device 1 and the system 100 with a device 1.

In a first method step S1, each transport container 10 is marked with the first marking system 11, for example an RFID transponder, in an electronically recognizable manner, and with respect to its transport position, the identified transport position is transmitted to the computer 20.

In a second method step S2, each storage container 3 with a second marking system 7 and an electronic detection system, which is recognizable for example in a data bus system 22, marked and identified with respect to a storage location of the storage bin 26n in the storage warehouse 2 and the identified storage position of the storage bin 26n to the computer 20 transmitted. The storage containers 3, filled with individual medicaments in each case, are inserted statically into the storage stand 21.

In step S3, an order for the individual compilation of medicaments is received by the computer 20 from an input unit 27.

In step S4, a defined transport container 10 is assigned to the order and defined storage containers 3 are determined for later transfer of the medicament. For this purpose, an individual electronic order list is assigned to each transport container 10 on the basis of the order for the compilation of medicaments in the computer 20.

In step S5, the transport system 12 is actuated by the computer 20, so that each transport container 10 below or next to each storage container 3 is successively moved through all the passages 13-19, so that by gravity one or more separated drugs each from a transport container 10 from the previously defined storage containers 3 are supplied.

Arranged on each storage container 3 is a reading and writing or data transfer system by means of which the first mark 11, and in particular, alternatively the electronic order list, is read when the transport container 10 passes.

In step S6, an actuator 4 for actuating the closure opening 5 and separate drug transfer of the defined storage container 3 triggered as soon as the defined and marked transport container 10 was transported under or next to the previously defined corresponding reservoir 3 for the transfer of separated drugs. Alternatively, the actuator 4 of a specific storage container 3 is actively decentrally activated for the separate transfer of medication, should a specific drug requirement of the storage container 3 be displayed from the order list.

In step S7, the transfer by means of the optical sensor 6 to the storage container 3 is detected and transmitted to the computer 20 via the data bus system 22. In the job list in the computer 20, a transfer of the drug is written. Thus, for each order, a tracking protocol is created in the order list of each transfer of a drug from an identified storage container 3 to an identified transport container 10 in the computer 20. Alternatively, this could also be done decentrally on the specific transport container 10.

The steps S5 to S7 are repeated successively until the transport container 10 has been carried out under all storage containers 3. This is done by a query step A57.

In the optional step S8, the transport container 10 is guided into the station 50 for sorting out in case of incorrect composition. The processed order list or the tracking protocol is checked for errors, and in the negative case, the composition of the drugs from the transport container is emptied before being transferred to the automatic blistering machine 60.

In step S9, the individual compilation of medicaments from the transport container 10 to an automatic machine 60 for individual packaging will be transferred to a transfer station 40.

In the automatic blistering machine 60, optionally in step S10, a photograph is taken by means of a camera 61 of the composition of the medicaments and transmitted to the computer 20 and added to the order with the tracking protocol, and stored in particular in an external data archive 28.

In step S10, the transport container 10 is turned at least to the side and in the cleaning station 30 by means of at least one brush 31 and a Suction device 32 cleaned.

The method is carried out partly with a computer program product with program code means when the computer program product runs on the computer 20 and / or is stored in a storage medium.

FIGS. 3-7 show various views of the transport system of the device with a linear guide track in which a conveyor belt runs. The transfer station is designed as a 360 ° turning section perpendicular to the transport direction by means of the linear guide track.

Further preferably, the transport system 12 has at least one drive spindle with teeth substantially in the vertical, preferably in the horizontal direction, which is designed in particular as a screw to a screw conveyor system, and the teeth engage in a transport chain or a conveyor belt to the transport chain or belt with the transport containers in each gear to move forward. In order to even better reduce slippage of the conveyor belt or the transport chain via the passage and to distribute the conveying forces more evenly, a drive spindle with teeth, which are driven synchronously with one another, is preferably provided at both ends of the passages of the transport system become.

FIG. 8 shows a plan view of a further particular embodiment of the device 1. At least three preferably at least four spindles 71 - 74 comprise the transport system 12 in order to form the storage stand 21 with a circulating transport chain. Thus, the spindles 71-74, wherein at least one spindle serves as a drive spindle for the transport system 12, in particular the transport chain, are built minimized in a resource-saving manner, and the storage stand 21 can be formed individually to the available installation space. The transfer station 40 and the cleaning station 30 are shown abstracted in the transport path behind the storage frame 21.

It is understood that a safety clutch with a correspondingly defined raw slip force between the electric drive motor and the at least one drive spindle can be provided in order to protect the electric drive from blockage and destruction if the transport system unexpectedly blocks due to an error could be. The variants of the method and the device described above merely serve to better understand the structure, the mode of operation and the properties of the solution presented; they do not limit the revelation to the exemplary embodiments. The figures are schematic, with essential properties and effects being shown, in some cases, significantly enlarged in order to clarify the functions, operating principles, technical features and features. In this case, every mode of operation, every principle, every technical embodiment and every feature which is / are disclosed in the figures or in the text can be combined with all claims, every feature in the text and in the other figures, other modes of operation, principles. pien, technical features and features contained in or resulting from this disclosure are freely and arbitrarily combined, so that all conceivable combinations attributable to the described solution. In this case, combinations are also included between all individual implementations in the text, that is to say in each section of the description, in the claims and also combinations between different variants in the text, in the claims and in the figures.

The device and method details explained above are shown in context; It should be noted, however, that they are independent of each other and can also be freely combined with each other. The ratios of the individual parts and sections thereof to one another and their dimensions and proportions shown in the figures are not to be understood as limiting. Rather, individual dimensions and proportions may differ from those shown.

The claims also do not limit the disclosure and thus the possibilities of combining all the features shown with each other. All listed features are also explicitly disclosed individually and in combination with all other features herein.

Claims

PATENT APPLICATIONS

1. Device (1) for a blistering of, in particular patient-individual, medicaments with a storage store (2) for a multiplicity of different medicaments, with transport containers (10) for an individual combination of medicaments, with a transport system (12) for the transport containers (10), wherein the storage warehouse (2) comprises a plurality of storage containers (3) which can be arranged statically on a storage stand (21), each with individual medicaments, the transport system (12) has at least one passage (13-19) comprises and the transport container (10) below or next to each individual storage container (3) by means of the transport system (12) successively in the at least one passage (13-19) are movable, so that by gravity one or more separated drugs in each case a transport container (10 ) from previously defined storage containers (3) can be fed directly and with a transfer station (40) for the transfer of the individual assembling medicaments from the transport container (10) to a blistering machine (60) for individually packaging the composition of medicaments.

2. Device (1) according to claim 1, wherein the transport system (12) comprises at least two superimposed passages (13-19), and the storage container (3) statically arranged over the at least two courses (14) are formed, wherein the aisles (14) in the plan view as a circle, further preferably formed as a slot circle and the transport system (12) is further preferably designed as a continuous rail.

3. Device (1) according to claim 2, wherein the aisles (14) of the transport system (12) have a slope at the circular sections, further preferred is a lift system or a conveyor lift or a screw conveyor system for the transport containers (10) Transport system (12) to promote the transport container (10) in the superposed passages.

4. Device (1) according to claim 3, wherein the transport system (12) at least one drive spindle with teeth substantially in vertical preferably in the horizontal direction, which is designed in particular as a worm to a screw conveyor system, and the teeth engage in a transport chain or a conveyor belt to move them forward in each passage.

5. Device (1) according to claim 4, wherein at least three preferably at least four spindles (71-74) comprise the transport system (12) to form the storage frame (21) with a circulating transport chain.

6. Device (1) according to claim 1 or 2, wherein each storage container (3) by means of an actuator (4), in particular by means of a servo motor, controllable closure opening (5), in order by means of gravity, the drugs for handover a defined transport container (10) is dispensed separately, and wherein the transport container (10) has a funnel opening (9), in particular funnel shape, and a bottom (24), the height of fall of the medicaments being from the closure opening (5) to the bottom (24) a maximum of about 200 mm, preferably a maximum of about 150 mm, more preferably a maximum of 80 mm.

7. Device (1) according to any one of the preceding claims, wherein a cleaning station (30) in the conveying path of the transport container (10) is formed and in particular the cleaning station (30) comprises a device with a brush (31) and a suction device (32). , more preferably with a Schwebstofffilter for the separation of suspended matter from the air is formed, wherein preferably the transport container (10) for cleaning in the cleaning station at least to the side, more preferably with the bottom (24) down 180 ° rotated by the transport system (12) are reversibly formed.

8. Device (1) according to one of the preceding claims, wherein the transport system (12) has a linear guide track in which a conveyor belt runs, and the transfer station (40) as a 360 ° turning section perpendicular to the transport direction by means of the linear guide track is trained.

9. System (100) with a device (1) for blinding of, in particular patient-specific, medicaments according to one of the preceding claims 1 to 5, wherein the system (100) comprises a central computer (20), which by means of a first marking system (11) markable transport container (10) via the transport system (12), the actuates the actuators of the reservoir (3) which can be marked by means of a second marking system (7) and which is connected to at least one sensor (6) of the marked reservoir (3), in particular and / or the transport container, via a data communication system ,

10. System (100) according to claim 7, wherein the storage bins (26n) in the storage rack (2) on the storage frame (21) are marked with a third marking system and these are in electronic contact with the computer (20) in data contact.

1 1. System (100) according to claim 7 or 8, wherein the sensors (6) and actuators (4) of the storage container (2) and at least one of the marking systems with a data bus system (22) and these with the computer (20) for data ten exchange and connected to the controller, wherein in particular the first marking system (1 1) comprises a security system.

12. System (100) according to any one of the preceding claims 7 to 9, wherein at each reservoir (3) a detection system is designed as a security system of the first marking system, which is in data communication with the computer (20).

13. System (100) according to one of the preceding claims 7 to 10, wherein at each storage container (3) an electronic reading and / or Datenzustungs- mediation or writing device is formed with the at least one defined position and a marker, in particular with RFID technology, the transport container (10) is readable and can be transmitted to the computer (20).

14. System (100) according to one of the preceding claims 7 to 1 1, wherein the system is formed with a station (50) for sorting out defective compositions of medicaments in front of the transfer station (40).

15. A method for operating a device (1) for the individual compilation of medicaments, with a device, in particular according to one of claims 1 to 5, wherein the device comprises a supply store (2) with a storage frame (21) the statically arranged storage container (3) is filled with individual medicaments and a transport system is provided for transporting medicaments in transport containers (10) in at least one passage (14), each transport container (10) below or next to each one storage containers is moved successively, so that by gravity one or more separated drugs each to a transport container (10) from previously defined storage containers (3) are supplied and at a transfer station (40) the individual compilation of drugs from the transport container ( 10) to a blister machine for individual packaging.

16. The method of claim 13 for operating a system according to any one of claims 7 to 12, wherein the transport containers (10) are marked by or with a first marking system and / or defined with respect to their transport position and / or the identified transport position the computer is transmitted, the storage container (3) marked with a second marking system and identified with respect to a storage location in the storage and the identified storage position is transmitted to the computer, an order for the collection of drugs is received by the computer, the order a defined Transportbehäl A defined reservoir for later drug transfer will be determined, with an actuator for actuating the closure opening and separated drug delivery of the defined storage container is controlled as soon as the defined transport container under or next to the previously defined the transfer by means of an optical sensor, in particular on the transport container or more preferably on the storage container, is detected and transmitted to the computer and at the end of the transport route, the compilation of the drug to the Blistering machine is handed over.

17. The method according to the previous claim 14, wherein from a security system with identification sensors on the defined storage container, which is provided for the transfer of drugs to a defined transport container, the defined transport container, in particular by means of Radio Frequency Identification RFID technology identified and this is transmitted to the computer. Alternatively, the position of the defined transport container is checked once in the transport run.

18. The method of claim 15, wherein for each order a racking protocol is created by each transfer of a drug from an identified storage container to an identified transport container in the computer.

19. The method according to any one of the preceding claims, wherein in the automatic tweeting a photo is taken by means of a camera of the composition of the drug and transmitted to the computer and is added to the order with the tracking protocol, and in particular in an external data archive is filed.

20. The method according to claim 1, wherein each transport container is assigned an electronic order list for the compilation of pharmaceuticals, a read and write or data transmission system is arranged at each storage container, by means of which the first mark, and in particular electronic Order list, when reading the transport container is read, the actuator of a specific reservoir for separate transfer of medicines, in particular actively decentralized, should be indicated from the order list, a specific drug need to be displayed and the order list a transfer of the drug is written be detected by the specific optical sensor handover, in particular at the station for sorting, the order list is checked for errors and emptied in the negative case, the composition of the transport container prior to transfer to the automatic blister becomes.

21. Computer program product with program code means for carrying out a method according to claim 15, wherein the computer program product runs on a computer and / or is stored in a storage medium.