EP3691599A1 - Poche contenant un produit biopharmaceutique et port support de sonde pour un tel produit - Google Patents
Poche contenant un produit biopharmaceutique et port support de sonde pour un tel produitInfo
- Publication number
- EP3691599A1 EP3691599A1 EP18786004.4A EP18786004A EP3691599A1 EP 3691599 A1 EP3691599 A1 EP 3691599A1 EP 18786004 A EP18786004 A EP 18786004A EP 3691599 A1 EP3691599 A1 EP 3691599A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- end portion
- probe
- axial
- contact
- support port
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/70—Device provided with specific sensor or indicating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/70—Device provided with specific sensor or indicating means
- A61J2200/72—Device provided with specific sensor or indicating means for temperature
Definitions
- the invention relates to a pocket containing a biopharmaceutical product and a probe support port for such a product.
- the invention also relates to an assembly for containing a biopharmaceutical product, comprising a pocket and a probe support port.
- the invention relates to an assembly for the measurement of a biopharmaceutical product, the assembly comprising on the one hand an assembly intended to contain a biopharmaceutical product, comprising a pocket and a probe support port, and on the other hand a probe by contact.
- biopharmaceutical product is meant a product derived from biotechnology, such as culture media, cell cultures, buffer solutions, artificial nutrition liquids, or a pharmaceutical product or more generally a product for use in the medical field. Such a product is in liquid, pasty, powdery form, in one or more phases, homogeneous or not, able to flow through a valve, thus being qualified as a fluid.
- the invention also applies to products other than biopharmaceuticals, according to the definition that has just been given, but which are subject to similar requirements with regard to their storage or treatment.
- the bag can be adapted for a bioreactor or a fermenter.
- the contact probe is in this case a probe for measuring parameters relating to the contents of the bag, such as pressure, pH, temperature, colorimetry, conductimetry, etc.
- the bags In the field of biopharmacy, it is customary to use the bags as a place for carrying out chemical or biological reactions, and where appropriate to monitor and / or control them, or as a means of storage. To prevent the penetration of germs inside the pocket, it is important that the environment is closed, sterile and aseptic, without contact with the external environment.
- the reactions must, in general, take place under determined and controlled conditions (pressure, pH, temperature, colorimetry, conductimetry, etc.) or storage under controlled conditions. It is therefore necessary to carry out more or less frequently controls or measurements of parameters characterizing the product contained in the pocket. These measurements must be carried out under aseptic conditions, for the reasons indicated above.
- the sensor device may for example consist of a probe.
- document WO 2013/083759 A1 discloses a probe as a sensor device.
- the probe disclosed by this document is a dry storable probe.
- a dry storable probe thus has the advantage of being easily storable, without constraints due to a buffer solution.
- This characteristic of dry storage is particularly advantageous.
- it makes it possible to store the assembly formed of the pocket and the probe without buffer solution.
- the bag does not require to contain buffer solution once the probe assembled to the bag.
- the manipulation of this type of probe is delicate.
- the measurement end of the probe intended to be in direct contact with the biopharmaceutical product that fills the pocket, can be easily damaged. It is the same during transport or use of the assembly formed by the probe and the pocket.
- An object of the invention is to provide a pocket containing a biopharmaceutical product and a probe support port for such a product does not have at least some of the disadvantages of devices of the prior art.
- the subject of the invention is a bag adapted to contain a biopharmaceutical product, said bag comprising:
- a flexible plastic envelope provided with at least one biopharmaceutical fluid inlet / outlet port and a measurement opening remote from the biopharmaceutical fluid inlet / outlet port, a first attachment zone surrounding said at least one opening measuring,
- a probe support port made in the form of a piece of thin thickness, the probe support port comprising a body provided with a through axial bore and a peripheral collar comprising a second attachment zone and defining a fixing plane; the body extending from an outer side to the flexible plastic envelope relative to the attachment plane, the first and second fixing zones being assembled together in a sealed manner by bonding or welding,
- a contact probe extending in the axial through bore, being assembled to the probe support port in leaktight manner, the contact probe comprising an active measuring end portion disposed in contact with a biopharmaceutical product when the pocket is filled, and an end portion opposite to the measuring active end portion,
- the probe support port comprising a transition portion between the body and the peripheral collar, extending between a radially central end portion of the peripheral collar and a first axial end portion of the body, the first end portion axial axis of the body being the axial end portion of the body closest to the radially central end portion of the peripheral collar, the first axial end portion of the body being disposed on the outer side relative to the attachment plane; measuring active end portion being disposed axially on the outer side relative to the attachment plane.
- the measuring active end portion of the probe is protected from damage that may occur during handling of the probe and / or the pocket.
- the transition portion is of conical shape, the diameter of the transition portion on the side of the peripheral collar being greater than the diameter of the body side. In one embodiment, the height of the transition portion is between 5 mm and 20 mm.
- the contact probe comprises an intermediate portion between the measuring active end portion and the end portion opposite to the measuring active end portion, the intermediate portion comprising at least one O-ring being in contact. sealed with the axial bore through the body.
- the contact probe is assembled to the body of the probe support port permanently.
- the body comprises a second axial end portion, the second axial end portion of the body being opposed to the first axial end portion of the body, and wherein the end portion opposite the portion of the body is active measuring end of the contact probe is of external diameter equal to the outer diameter of the second axial end portion of the body.
- the outer diameter of the intermediate portion of the contact probe is smaller than the diameter of the end portion opposite to the active measuring end portion of the contact probe.
- the diameter of the axial through bore of the body of the probe support port decreases from the second axial end portion of the body toward the first end portion of the body.
- a locking element is disposed externally around the body and the end portion opposite to the active measuring end portion of the probe by contact.
- the body comprises on its outer surface a circular stop for holding the locking element, adapted to cooperate with the locking element.
- the locking element is of cylindrical and hollow shape and comprises an axial through bore axis coinciding with the axis of the axial bore through the body.
- the subject of the invention is an assembly intended to contain a biopharmaceutical product, the assembly comprising a pocket and a probe support port, said pouch comprising a flexible plastic casing provided with at least one biopharmaceutical fluid inlet / outlet port and a measurement aperture remote from the biopharmaceutical fluid inlet / outlet port, a first attachment area surrounding said at least one biopharmaceutical fluid inlet / outlet port; an opening of measurement,
- the probe support port being made in the form of a piece of thin thickness, the probe support port comprising a body provided with a through axial bore and a peripheral collar comprising a second attachment zone and defining a fastening plane, the body extending from an outer side to the flexible plastic envelope relative to the attachment plane, the first and second fixing zones being assembled together in a sealed manner by bonding or welding,
- the probe support port comprising a transition portion between the body and the peripheral collar, extending between a radially central end portion of the peripheral collar and a first axial end portion of the body, the first end portion axial axis of the body being the axial end portion of the body closest to the radially central end portion of the peripheral collar, the first axial end portion of the body being disposed on the outer side relative to the attachment plane; measuring active end portion being disposed axially on the outer side relative to the attachment plane.
- Figure 1 is an overview of a pouch containing a pharmaceutical product according to the invention.
- Figure 2 is a perspective view of a probe support port according to the invention.
- FIG. 3 is a sectional view of a probe support port and a contact probe according to the invention.
- FIG. 1 illustrates a pocket 11. Such a pocket 1 is adapted to contain a biopharmaceutical product.
- the pouch 11 comprises a flexible plastic envelope 12.
- the flexible plastic envelope 12 is provided with at least one input / output port 13 for the biopharmaceutical fluid.
- the bag 11 further comprises a measurement opening 14 and a first attachment zone 15 surrounding the measurement opening 14.
- the measuring opening 14 is designed to measure different parameters of the biopharmaceutical product, such as, for example, the pH of the product. .
- the measuring aperture 14 is remote from the input / output port 13. In other words, the measurement aperture 14 and the input / output port 13 are distinct from each other. 'other.
- the pocket 11 comprises, at the measurement opening 14, a contact probe 22 and a probe support port 16.
- the contact probe 22 is cylindrical in shape.
- the contact probe 22 is provided for measuring a parameter of the biopharmaceutical product contained in the pocket 11.
- the contact probe 22 makes it possible to measure the pH of the product.
- contact probe is meant here a probe that requires physical contact with the product to be measured (as opposed to for example an optical probe). It may also be possible to measure other parameters such as pressure, temperature, colorimetry etc.
- the contact probe 22 includes a measuring active end portion 23 and an opposite end portion 24.
- the opposite end portion 24 includes an outer diameter D24.
- the outer diameter D24 is between 21.5 mm and 27.5 mm.
- the external diameter D24 is 24.5 mm.
- the measuring active end portion 23 is placed in contact with a biopharmaceutical product when the bag 11 is filled with it.
- the measuring active end portion 23 comprises for example two electrodes.
- one of the two electrodes is standard and called reference electrode.
- the potential of this reference electrode is constant and known.
- the other of the two electrodes is of variable potential and called glass electrode.
- the potential of this glass electrode is a function of the pH. According to the example illustrated in particular in Figure 1, the two electrodes are separated. However, both electrodes can be combined.
- the measuring active end portion 23 is closer to the pocket 11 than the opposite end portion 24.
- the contact probe 22 further comprises an intermediate portion 28
- the intermediate portion 28 is arranged between the measuring active end portion 23 and the opposite end portion 24.
- the intermediate portion 28 includes an outer diameter D28.
- the outer diameter D28 is between 19.5 mm and 22.5 mm.
- the outer diameter D28 is 20.7 mm.
- the outer diameter D28 of the intermediate portion 28 is therefore smaller than the outer diameter D24 of the opposite end portion 24.
- the intermediate portion 28 comprises a bulge 29.
- the intermediate portion 28 may include several bulges 29.
- the intermediate portion 28 comprises two circular grooves. The first circular groove is disposed on the side of the measuring active end portion 23 with respect to the bulge 29, and the second circular groove is disposed on the side of the opposite end portion 24 with respect to the bulge 29. Each circular groove receives an O-ring 38.
- the probe support port 16 is in the form of a piece of thin thickness.
- the thickness of the probe support port 16 varies between 1 mm and 3 mm.
- the probe support port 16 is made by injection.
- the probe support port 16 comprises a body 17, a transition portion 25 and a peripheral flange 19.
- the body 17 is generally cylindrical in shape.
- the body 17 comprises on its outer surface a circular stop 32.
- the body 17 is provided with a through axial bore 18.
- the axial through bore 18 is provided for the passage of the probe by contact 22.
- the probe by contact 22 is thus assembled to the body 17.
- the contact probe 22 is assembled to the body 17 by casting a Resin between the contact probe 22 and the body 17.
- the contact probe 22 is force-fitted to the body 17. As a result, it is difficult to separate the contact probe 22 from the probe support port 16 once the contact probe 22 is assembled with the body 17.
- the bulge 29 of the contact probe 22 and the O-rings 38 are in sealing contact with the axial bore 18 passing through.
- the first axial end portion of the body 27 is the axial end portion of the body closest to the active end portion measurement 23 of the contact probe 22 when the contact probe 22 is inserted into the probe support port 16.
- the second axial end portion of the body 30 is opposite the first axial end portion of the body 17.
- the axial end portion portion of the body 30 includes an outer diameter D30.
- the outer diameter D30 is identical to the diameter D24 of the opposite end portion 24 of the contact probe 22.
- the outer surfaces of the second axial end portion of the body 30 and the opposite end portion 24 of the contact probe 22 are flush.
- the outer diameter D30 is between 21.5 mm and 27.5 mm.
- the external diameter D30 is 24.5 mm.
- the through axial bore 18 comprises a diameter D18.
- the diameter D18 is between 18 mm and 25 mm. More specifically, the diameter D18 is not constant over the entire length of the axial through bore 18. In fact, the diameter D18 decreases from the second axial end portion of the body 30 towards the first end portion For example, the distance measured between the two end portions 27 and 30 is 1.4 mm.
- the surface of the axial through bore is inclined by 2.3 ° to the second axial end portion 30.
- the surface of the axial through bore is inclined 0.5 ° to the first axial end portion 27.. This decrease facilitates in particular the assembly of the probe by contact 22 with the probe support port 16.
- the peripheral collar 19 extends perpendicular to the body 17. It comprises a first surface 19A and second surface 19B. The first surface 19A is oriented on the side of the body 17. The second surface 19B is opposite the first surface 19A.
- the peripheral collar 19 comprises a second attachment zone 20. The second attachment zone 20 defines a fastening plane 21.
- This second attachment zone 20 is circular, of external diameter D20 and of internal diameter D20 '.
- the external diameter D20 is between 80 mm and 90 mm.
- the outer diameter D20 is 85 mm.
- the internal diameter D20 ' is between 52 mm and 57 mm.
- the internal diameter D20 ' is 54.4 mm.
- the inner diameter D20 ' limits the radially central end portion 26 of the peripheral flange 19.
- the second attachment zone 20 corresponds to the first surface 19A.
- the second attachment zone 20 may correspond to the second surface 19B.
- the second attachment zone 20 is provided to be in contact with the first attachment zone 15 of the pocket 11.
- the first and second attachment zones 15, 20 are assembled together in a sealed manner.
- first and second attachment zones 15, 20 are assembled together by gluing or welding.
- the assembly between the first and second attachment zone 15, 20 is by welding. Unlike bonding, the weld does not potentially lead to contamination within the pocket 1 due to the sticky agent.
- the flexible plastic casing 12 is welded to the first surface 19A of the flange 19.
- the probe support port 16 is thus firmly attached to the pocket 11, and sealingly. Once the probe support port 16 is assembled to the pocket 11, the attachment plane 21 defines a side outside the pocket 11 and an inside.
- the biopharmaceutical product present in the pocket 11 extends on the inner side with respect to the fastening plane 21 while the probe support port 16 extends on the outer side with respect to the fastening plane 21, in its entirety when the second fixing zone 20 corresponds to the second surface 19B, or almost all of it when the second fixing zone 20 corresponds to the first surface 19A.
- the transition portion 25 is disposed between the body 17 of the probe support port 16 and the peripheral collar 9. More specifically, the transition portion 25 extends between the radially central end portion 26 of the peripheral collar 19 and the first axial end portion of the body 27. As shown in Figures 2 and 3, this transition portion 25 is conical. A conical shape has the advantage of avoiding sharp edges, which could be at the origin of a deterioration of the flexible plastic envelope 12 of the pocket 11. In addition, the transition portion 27 is sized to allow good circulation of the biopharmaceutical product within the conical portion. A good circulation of the pharmaceutical product thus makes it possible not to distort the measurements taken by the probe by contact 22.
- the diameter of the transition portion 25 is greater on the side of the attachment plane 21 than on the side of the first end portion
- the shape of the transition portion 27 makes it possible to protect the probe by contact 22 with the various degradations that it could undergo, in particular because of the transport or use of the pocket 1 or even when from the step of assembling the contact probe 22 to the pocket 11, the pocket 1 being previously provided with the probe support port 16.
- the height H25 of the transition portion 25 is between 5 mm and 20 mm.
- the height H25 is between 9.7 mm and 10.3 mm.
- the height H25 is 10 mm.
- the height H25 is measured between the plane 21 and the first axial end portion of the body 27, at the axial through bore 18.
- the first axial end portion of the body 27 is therefore distant from the plane 21.
- the active measuring end portion 23 of the contact probe 22 is distant from the plane 21.
- the height H25 thus makes it possible to move the active measuring portion 23 away from the plane 21.
- the probe support port 16 thus makes it possible to protect the probe by contact 22 while maintaining a simple configuration.
- the probe support port 16 makes it easier to mount the probe by contact 22 and also to protect it during the step of assembling the probe by contact 22 in the probe support port 16. Indeed the port probe support 16 is previously assembled to the pocket 11. For example, the probe support port 16 is inserted into the pocket 11.
- the probe support port 16 is passed through the measurement opening 14.
- the body 17 and the transition portion 25 extend from the outer side of the pocket 11 and the flange extends on the inner side of the pocket 11.
- the first and second attachment zone 15, 20 are then assembled together.
- the operator places the pocket 11 flat on a hard support, for example a table, making sure that the flange 19 is laid flat with respect to the support.
- the operator then inserts the contact probe 22 into the probe support port 16.
- the dedicated form of the probe support port 16 prevents the measurement end 23 of the contact probe 22 from being damaged by contact with the envelope flexible plastic 12 of the pocket 11 facing resting on the support.
- the operator can exert a force slightly greater than that necessary to introduce the probe by contact 22 in the probe support port 16 without the risk of damaging the latter.
- the pocket 11 comprises a locking member 31.
- the element locking 31 contributes to the assembly of the probe by contact 22 with the probe support port 16.
- the locking member 31 is held by elastic casing around the body 7 of the probe support port 16.
- the element locking member 31 comprises a cylindrical portion 33, a first end portion 34 and a second end portion 35.
- the locking member 31 is disposed externally around the body 17 and the end portion 24 opposite the portion active measuring end 23 of the probe by contact 22.
- the cylindrical portion 33 surrounds the body 17 and the end portion 24.
- the cylindrical portion 33 comprises an axial bore t
- the axis of the axial through bore 36 is coincident with the axis of the axial through bore 18 of the body 17.
- the cylindrical portion 33 further comprises an internal diameter D33.
- the first end portion 34 extends radially to the cylindrical portion 33.
- the first end portion 34 is disposed in contact with the opposite end portion 24 of the contact probe 22.
- the first end portion 34 further comprises an opening 37.
- the opening 37 is able to pass the connective elements connected to the probe by contact 22.
- the second end portion 35 extends radially to the cylindrical portion 33.
- the second portion of end 35 cooperates with the circular stop 32 of the body 17 of the probe support port 16.
- the circular stop 32 holds the locking member 31 in position around the contact probe 22 and the probe support port 16.
- the invention is not limited to the examples described above but is capable of numerous variants accessible to those skilled in the art.
- the above description refers to a probe by contact 'the probe support port may be adapted to any measuring device such as for example optical sensors, temperature sensors, pressure sensors.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1771039A FR3071724A1 (fr) | 2017-10-02 | 2017-10-02 | Poche contenant un produit biopharmaceutique et port support de sonde pour un tel produit |
PCT/FR2018/000224 WO2019068964A1 (fr) | 2017-10-02 | 2018-09-26 | Poche contenant un produit biopharmaceutique et port support de sonde pour un tel produit |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3691599A1 true EP3691599A1 (fr) | 2020-08-12 |
Family
ID=61913344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18786004.4A Pending EP3691599A1 (fr) | 2017-10-02 | 2018-09-26 | Poche contenant un produit biopharmaceutique et port support de sonde pour un tel produit |
Country Status (4)
Country | Link |
---|---|
US (1) | US11633328B2 (fr) |
EP (1) | EP3691599A1 (fr) |
FR (1) | FR3071724A1 (fr) |
WO (1) | WO2019068964A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD959656S1 (en) | 2020-04-17 | 2022-08-02 | Fresenius Medical Care Holdings, Inc. | Injection site with trifurcated connector |
USD956966S1 (en) | 2020-04-17 | 2022-07-05 | Fresenius Medical Care Holdings, Inc. | Injection site with frangible connector |
CN116569030A (zh) * | 2020-06-19 | 2023-08-08 | 平多技术有限公司 | 用于生物技术工艺袋的传感器配件 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004015703B4 (de) * | 2004-03-29 | 2023-03-02 | Sartorius Stedim Biotech Gmbh | Vorrichtung für das Einbringen von Sensoren in eine sterile Umgebung |
CN101983324B (zh) * | 2008-03-31 | 2014-02-26 | Atmi包装公司 | 用于柔性容器完整性测试的设备和方法 |
US8838395B2 (en) * | 2010-09-09 | 2014-09-16 | S.E.A. Medical Systems, Inc. | Systems and methods for intravenous drug management using immittance spectroscopy |
FR2978131B1 (fr) * | 2011-07-19 | 2013-09-13 | Sartorius Stedim Biotech Sa | Perfectionnement au raccordement d'un accessoire a un recipient. |
US20130145818A1 (en) | 2011-12-09 | 2013-06-13 | Mettler-Toledo Ag | Sensor unit utilizing a clamping mechanism |
US8534120B1 (en) * | 2012-09-14 | 2013-09-17 | Advanced Scientifics, Inc. | Test system and method for flexible containers |
US10557811B2 (en) * | 2013-12-06 | 2020-02-11 | Pendotech | Sensor fitting for biotech process bag |
EP3076917B2 (fr) * | 2013-12-06 | 2021-06-02 | Pendo TECH | Armature de capteur pour sac de traitement biotechnique |
US9606037B2 (en) * | 2015-01-23 | 2017-03-28 | Aesynt Incorporated | Fluid container with fluid identification sensor and method |
FR3033696B1 (fr) * | 2015-03-19 | 2017-04-21 | Sartorius Stedim Fmt Sas | Poche multi-enveloppes et systemes et procedes de detection d'une eventuelle perte d'integrite d'une telle poche |
EP3719474A1 (fr) * | 2019-04-02 | 2020-10-07 | Sartorius Stedim Fmt Sas | Procédé et système utilisant un indicateur colorimétrique pour détecter une perte possible d'intégrité d'un sac flexible pour un produit biopharmaceutique |
-
2017
- 2017-10-02 FR FR1771039A patent/FR3071724A1/fr active Pending
-
2018
- 2018-09-26 EP EP18786004.4A patent/EP3691599A1/fr active Pending
- 2018-09-26 US US16/652,846 patent/US11633328B2/en active Active
- 2018-09-26 WO PCT/FR2018/000224 patent/WO2019068964A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
US20200230023A1 (en) | 2020-07-23 |
FR3071724A1 (fr) | 2019-04-05 |
US11633328B2 (en) | 2023-04-25 |
WO2019068964A1 (fr) | 2019-04-11 |
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