EP3641659A1

EP3641659A1 - Device for preparing a sample to be analyzed and method for preparing a sample to be analyzed

Info

Publication number: EP3641659A1
Application number: EP18733599.7A
Authority: EP
Inventors: Walter Franz
Original assignee: Gaudlitz GmbH
Current assignee: Gaudlitz GmbH
Priority date: 2017-06-23
Filing date: 2018-06-22
Publication date: 2020-04-29
Also published as: DE102017114032A1; AU2018287424A1; WO2018234566A1; US20200170626A1

Abstract

The invention relates to a device for preparing a sample to be analyzed, in particular a stool sample, comprising a first container, which has a first container opening and which forms an accommodating chamber for a suspension liquid, in which suspension liquid the sample is at least partially contained, a second container, which has a second container opening and which forms a second accommodating chamber, wherein the first container can be or is at least partially accommodated in the second accommodating chamber, and a sample holder for inserting into the first container opening. The invention is characterized in that, in the first container, a liquid passage is formed, and that the first container and the second container are designed in such a way that suspension liquid passes from the first accommodating chamber into the second accommodating chamber when the first container is moved out of the second accommodating chamber. The invention further relates to a method for preparing a sample to be analyzed.

Description

Apparatus for preparing a sample to be analyzed and method for preparing a sample to be analyzed

The present invention relates to a device for the preparation of a sample to be analyzed, in particular a stool sample, comprising a first container having a first container opening and a

A receiving space for a suspension liquid in which the sample is at least partially contained, forms a second container, the second

Container opening and forms a second receiving space, wherein the first container in the second receiving space at least partially

is receivable or received, and a sampler for insertion into the first container opening. The invention further relates to a method for preparing a sample to be analyzed.

An apparatus for the preparation of a sample to be analyzed is known from DE 10 2008 057 866 A1.

The object of the invention is to provide a device for the preparation of a sample to be analyzed, in particular a stool sample, whose handling is particularly simple and safe. The invention also has the task of providing a method for the preparation of a

indicate analyzing sample, which has improved handling.

The object is achieved in a device having the features of claim 1. Accordingly, it is provided in the device mentioned above that in the first container, a liquid passage is formed, and that the first and the second container are formed such that the suspension liquid from the first receiving space in the second Receiving space passes when the first container from the second

Recording room is moved out. This design makes it possible to prepare a sample in a particularly simple manner. In particular, the design allows the sample to be analyzed, such as

especially a stool sample, in a liquid that is in the first

Receiving space may be included, at least partially dissolved, to form the suspension liquid. Then, the first container can be moved out of the second container (in particular pulled out), wherein at least a part of the suspension liquid through the

Liquid passage passes into the second receiving space. In particular, insoluble constituents in the first receiving space

be withheld. This is essential for subsequent analysis in an analyzer. Especially at

Automated and / or sensitive analytical devices can cause insoluble components to interfere with the analysis process. Optionally, insoluble components can also lead to failure of the analyzer. With the invention, this can be reliably avoided. The handling is easy, whereby an unwanted contact with the sample material is avoided. The device allows hygienic handling, especially in a stool sample. In addition, adverse effects on the analysis result can be avoided. In addition to the preparation of the sample, the device can also be designed to carry out the sampling (in particular a stool sample).

The object is further achieved by a method for preparing a sample to be analyzed, in particular a stool sample, with the following steps:

Providing the described device for the preparation of the sample to be analyzed, with a first and a second one

Container; Introducing a liquid into the first receiving space;

Introducing the sample into the first receiving space; Mixing the sample with the liquid to produce a

Suspension liquid in the first receiving space;

Moving out of the first container from the second container, wherein suspension liquid passes through the liquid passage from the first receiving space into the second receiving space.

Hereinafter, further advantageous features of the device and the method are described, which form the subject of the invention individually or in any meaningful combination.

According to an advantageous embodiment of the invention, it is provided that the first and the second container are designed such that when

Moving out of the first container from the second receiving space on the liquid passage, a negative pressure is created, so

Suspension liquid from the first container through the

Fluid passage is conveyed into the second container. In particular, in this way the suspension liquid through the

Liquid passage are sucked. According to an advantageous embodiment of the invention it is provided that between the first and the second container, a vacuum chamber

is formed, which communicates with the fluid passage. The vacuum chamber may in particular be sealed off from the environment by the seal described below. When pulling out of the vacuum chamber takes on the liquid that has passed through the fluid passage. According to an advantageous embodiment of the invention, it is provided that a seal is provided, which seals the first container relative to the second container such that when pulling out the first

Container from the second container at the liquid passage

Negative pressure is created, so that the suspension liquid is conveyed from the first container through the liquid passage in the second container.

According to an advantageous embodiment of the invention it is provided that the seal comprises at least one circumferential projection which is arranged on the first and / or the second container. Preferably, the circumferential projection is arranged on an outer side of the first container or on an inner side of the second container. The arrangement of the circumferential projection on the outside of the first container is preferred. The circumferential projection may be formed in particular by a radially outwardly projecting portion of the side wall or the bottom portion of the first container. Such a section can be produced in each case during the production of the first body by injection molding, wherein no additional installation effort arises. In addition, in the side wall or in the bottom portion of the first container, a receptacle for a sealing element (e.g., a sealing ring) may be provided which forms the circumferential projection. Such a receptacle is preferably formed groove-shaped circumferentially. According to a particularly preferred embodiment of the invention

provided that a filter is arranged on the fluid passage. The filter allows the suspension liquid as it passes through the

Filter fluid passage. This can be prevented particularly effectively that unwanted particles reach the second receiving space. The filter may include, for example, a fiber-containing filter material. Alternatively or additionally, the filter may have at least one filter opening, which may be arranged, for example, in a plastic part. In particular, the filter may be formed by a sieve, for example made of plastic.

Preferably, the first container has a side wall and a bottom portion. The liquid passage may be disposed in the bottom portion. It is preferred if the first container is tubular. In particular, the first container is elongated. Preferably, the first container has a circular cross-section. Preferably, the second container has a side wall and a bottom portion. It is preferred if the second container is tubular. In particular, the second container is elongated. Preferably, the second container has a circular cross-section. The bottom portion and the side wall of the second container may in particular be integrally formed.

Preferably, the second container has an inner contour which is slightly larger than an outer contour of the first container. In this way, the first container can be slidably received in the second container.

Preferably, the first container forms an inner sleeve and the second container forms an outer sleeve.

According to the invention, it is provided that the device has a

Includes sampler, which is insertable into the first container opening. Preferably, the sample receiver has one or more depressions in which a defined amount of the sample can be received. Preferably, the sample receiver is elongated. In particular, the sample receiver may be a sample receiver rod. The sampler can have a

Having connecting portion, with which it is inserted into a recess of the handle member. Depending on the requirement of the analysis, the sampler may be interchangeable. In each case depressions with a shape adapted to the shape and / or volume can be provided. It is preferably provided that on the first container a

Scraper for the sampler is provided. In particular, the stripping device can be designed as a stripping sleeve. This ensures that only the desired amount of sample in the first

Receiving space. When the sampler is introduced into the first receiving space, the stripping device can rest on the sampler in such a way that excess sample material is stripped off.

In particular, sample material which projects beyond the depressions can be stripped off. In this case, the stripping device preferably forms a calibration bore which enables an exact metering of the amount of sample introduced into the first receiving space. In addition, an additional seal can be achieved with the stripping device, in that the stripping device bears sealingly against the sampler. If, prior to insertion of the sample receiver into the first receiving space, the sample receiver has a slightly larger diameter than the elastically formed scraping device, it can rest against the sample receiver under prestress and thus ensure improved sealing.

It is preferably provided that a closure is provided which seals the container opening of the first container in a liquid-tight manner. Preferably, the closure comprises a cap. Preferably, the closure comprises a plug which is insertable or inserted into the container opening. On the closure extending in the radial direction sealing lips may be provided, which bear against an inner side of the first container.

Preferably, the closure has a grip element. In particular, the handle element may have two opposite gripping surfaces. Then, the handle element can be particularly easily held with two fingers. The closure preferably has a knurled surface on its outer circumference.

Preferably, the closure has a seal which seals the closure against the first container. The seal may in particular comprise a cone-shaped sealing element.

Preferably, the closure can be brought into a partially opened position, in which the first receiving space is connected to the environment when the closure is attached. This way, air can be in the first

After receiving space, while the first container is pulled out of the second container and suspension liquid is conveyed from the first into the second receiving space. Furthermore, in a preferred manner to achieve an effective

Seal between the first container and the closure may be provided that an inner contour is formed conically on the first container. In particular, the first container at the first container opening may have a conical inner contour which forms a sealing edge.

Preferably, it is provided that the closure via a

Bayonet lock is connected to the first container. It is preferred if the way to move the closure from the closed to an open position of the bayonet is between 30 ° and 90 °, preferably between 50 ° and 70 °. Preferably, the

Bayonet lock on a locking function. For this purpose, the bayonet lock bayonet tabs, which each have a nose on a leading edge. As a result, unintentional opening can be avoided. Preferably, the bayonet lock has a recess which is arranged in a tab of the closure and cooperates with a projection which is formed on the side wall of the first container. It is preferably provided that the sample receiver is arranged on the closure.

It is preferably provided that a holding element is provided to fix the first container to the second container when it is arranged in the second receiving space. In particular, the holding element may comprise a bayonet closure. It is preferred if the

Bayonet closure comprises a projection on the outside of the first container, which is receivable in a recess which is formed in the side wall of the second container. Furthermore, the retaining element can also be a screw connection between the first and the second

Containers.

It is preferably provided that the bottom portion of the first container is formed by a separate element which bears sealingly against the side wall. This contributes to a simple manufacturability and allows a cost-effective production by injection molding. In particular, the separate element may comprise a plug. Furthermore, it is preferred if the separate element has a sealing portion for bearing against the inside of the second container. Preferably, the sealing portion as

Be formed sealing bead.

The bottom portion and the side wall of the first container may also be formed in one piece. In this way, the first container can be produced by injection molding in a single process step.

The second container preferably has an elastic material that can be pierced with a syringe, at least in one section. It is preferred if the portion is arranged with the pierceable material in the bottom portion. The production of the second container thus formed is particularly simple when the bottom portion is a separate part which is connected to the side wall of the first container. In this way The suspension solution can be safely and hygienically removed with a syringe from the second container. It is not necessary to remove the first container. It is preferably provided that the filter is arranged in the bottom portion of the first container.

Preferably, it is provided that the filter has a tapered in a direction away from the bottom portion of the element. In particular, the tapered element may be conical or pyramid-shaped.

It is preferably provided that the bottom portion of the first container has a base and a holding portion for the filter.

Preferably, it is provided that the holding portion is configured so that the upper end of the filter is spaced from the base. Preferably, an annular space is formed by the holding portion and the base. This improves the transfer of suspension liquid through the filter.

It is preferably provided that the device and the method are designed to carry out a diagnostic test. It is preferably provided that the device as

Stool sampling device is formed.

It is preferably provided that the first and the second container comprise plastic parts, which are produced by injection molding. In addition, it is advantageous if the sample pick-up and the closure are plastic parts which are produced by injection molding. Preferably, the device comprises a further closure for liquid-tight sealing of the second container. In this way, the second container can be closed after the first container has been removed. The further closure can also be provided with a bayonet closure.

Preferably, the liquid is introduced into the first receiving space in front of the sample. Preferably, an outwardly projecting annular retaining portion is provided on the first container. This facilitates handling and can be used in particular as a withdrawal aid when the first container is moved out of the second container. It is particularly preferred if the annular portion has a radially outwardly facing knurling, which can be easily grasped by a user. Furthermore, the protruding annular portion may have a corrugation on its side facing the second container.

In a preferred embodiment, it is provided that a total length of the first container is more than 50% greater than an overall length of the second container.

Preferably, the bottom portion of the first container has a conical outer contour. Furthermore, it is preferred if the bottom portion of the second container has a conical inner contour, wherein the conical outer contour of the conical inner contour opposite, when the first container is inserted into the second container. In this way, a particularly efficient sample material yield is achieved. Other objects, features, advantages and applications of the present invention will become apparent from the following description of exemplary embodiments and the drawings. All form

described and / or illustrated features alone or in bbeelliieebbiiggeerr ssiinnnnvvoolllleerr KKoommbbiinnaattiioonn ddeenn GGeeggeennssttaanndd tthhee EErrffiinndduunngg ,, aauucchh uunnaabbhhäännggiigg ooff tthhee ZZuussaammmmeennffaassssuunngg iinn eeiinnzzeellnneenn AAnnsspprrüücchheenn ooddeerr ddeerreenn RRüücckkbbeezziieehhuunnggeenn .. In the drawings:

Fig. 1a: shows a device according to the invention from a first side; Fig. 1 b: shows the device of Figure 1 a from a second side;

FIG. 1 c: shows the device from FIG. 1 b in a longitudinal section along the

Line A-A of Figure 1 b;

Fig. 1 d: shows the device of Figure 1 c with suspension liquid and arranged with a rotated by 180 °

sampler;

Fig. 2a: shows the device of Figure 1 d with a partial

pulled out first container from a first side;

Fig. 2b: shows the container of Fig. 2a from a second side;

Fig. 2c: shows the container of Figure 2b in longitudinal section along the line

A-A;

Fig. 3a: shows the device of Figure 2a with a still further

pulled out first container from a first side;

Fig. 3b: shows the container of Fig. 3a from a second side;

Fig. 3c: shows the container of Figure 3b in longitudinal section along the line

A-A;

FIG. 4 a shows the second container of the device from FIG. 1 a with the further closure from a first side;

Fig. 4b shows the container of Fig. 4a from a second side;

Fig. 4c: shows the container of Figure 4b in a longitudinal section along the line A-A;

Fig. 4d: shows the container of Figure 4c with suspension liquid;

Fig. 5a: shows the side wall of the first container of the device of Figure 1 a from the side;

Fig. 5b: shows the side wall of Figure 5a in a longitudinal section; Fig. 6a: shows the closure of the first container of the device

Figure 1 a from the side;

Fig. 6b: shows the closure of Figure 6a in longitudinal section;

Fig. 7a: shows a separate element, the bottom portion of the first

Container of Figure 1 c forms, in a side view;

Fig. 7b: shows the separate element of Figure 7a in longitudinal section;

Fig. 8: shows the sampler of the device of Figure 1 c in one

Side view;

Fig. 9a: shows the second container of the device of Figure 1 c in one

Side view;

Fig. 9b: shows the second container of Figure 9a in a longitudinal section; FIG. 10a: shows the further closure of the device from FIG. 4a in a side view;

Fig. 10b: shows the further closure of Figure 10a in one

Longitudinal section;

Fig. 11a-c: the introduction of a stool sample with the sampler into the first container;

Fig. 12a-b: a further embodiment of an inventive

Device from the side and in longitudinal section;

Fig. 13a-b: another embodiment of an inventive

Device from the side and in longitudinal section;

Fig. 14a-b: a further embodiment of an inventive

Device from the side and in longitudinal section;

Fig. 15a-b: another embodiment of an inventive

Device from the side and in longitudinal section;

FIGS. 1 - 1 c show an apparatus for preparing a sample to be analyzed, which comprises a first container 1 and a second container 2. The first container 1 has a side wall 3 and a bottom portion 4, which has a first receiving space 5

limit. The second container 2 has a side wall 6 and a bottom section 7, which delimit a second receiving space 8. The first container 1 has a first container opening 9 and the second container 2 a second container opening 10. The first container 1 and the second container 2 are tubular in shape and each have an elongated shape. The illustrated device is particularly suitable for a stool sample. As can be seen in particular from FIGS. 5a, 5b, 9a and 9b, the first container 1 and the second container 2 are separate components which

In particular, by injection molding of plastic can be produced. The first container 1, as shown for example in Figures 1 a to 1 c, be arranged in the second container 2 slidably. In this case, the first container 1 forms an inner sleeve and the second container 2 forms an outer sleeve.

The apparatus shown moreover has a sample receiver 11, which can be introduced into the first receiving space 5 with sample material as shown in FIGS. 11a-c. As shown in FIG. 1 d, a suspension liquid 12 can be introduced into the first receiving space 5. An introduced sample can be completely or partially dissolved in the suspension liquid 12. Figures 1 a - 3c further show that the first container 1 is provided with a closure 17. The closure 17 has a grip element 18. The sampler 1 1 is held on the shutter 17. The

Sample receiver 1 1 is arranged on the closure 17 in such a way that the sample receiver 1 1 is located in the first receiving space 5 when the closure 17 is placed on the first container 1.

To prepare the sample for analysis, the first container 1 can be pulled out of the second container 2. FIGS. 2a-2c show the partially withdrawn first container 1. Upon withdrawal, suspension liquid 12 containing soluble components of the sample is disposed through one in the first container 1

Fluid passage 13 is conveyed into the second receiving space 8. As shown, a seal 14 is provided, the first container. 1 seals against the second container 2. In this way, upon withdrawal of the first container 1 from the second container 2 effectively a negative pressure in the vacuum chamber 15 can be achieved. The first and the second container 1, 2 are thus designed so that when moving out of the first container 1 from the second receiving space 8 at the liquid passage 13, a negative pressure is created, so

Suspension liquid from the first container 1 through the

Liquid passage 13 can be promoted in the second container 2.

FIGS. 3 a - 3 c show the first container 1, which is pulled further out of the second container 2. As FIG. 3 c in particular shows, the suspension liquid 12 has now passed from the first receiving space 5 into the second receiving space 8. Undesirable particles (not shown) can be retained by the liquid passage 13 in the first receiving space 5. For this purpose, the

Liquid passage 13 may be provided with a filter 16.

The filter 16 makes it possible to filter the suspension liquid when passing through the liquid passage 13. The filter may include, for example, a fiber-containing filter material and / or be formed as a sieve.

The figures further show that the liquid passage is arranged in the bottom section 4. As shown, the bottom portion 4 is a separate component which is inserted into the side wall 3. In this way, the bottom portion 4 can be made separately with the liquid passage 13 and the filter 16 and then connected to the side wall 3, as shown.

Figures 4a - 4d show the second container 2 after the complete

Removing the first container 1. In order to avoid an undesired escape of the suspension liquid 12, the second container 2 with a removable closure 20 provided. The closure 20 is over a

Bayonet closure connected to the second container 2.

In particular, FIG. 5 a shows that the seal 14 comprises peripheral projections which are located on the outside of the first container 1

are arranged. In the illustrated embodiment, two circumferential projections are provided.

FIGS. 6a and 6b show the closure 17, which has the grip element 18 and the sealing element 22.

Figures 7a and 7b show an enlarged view of the bottom portion 4 of the first container. 1 In particular, it is easy to see that the

Bottom portion 4, the liquid passage 13 and the filter 16 disposed therein. In this case, the bottom section 4 has a base 31 and a holding section 32 for the filter 16. The holding portion 32 is designed such that the upper end of the filter 16 is spaced from the base 4. In this way, an annular space 33 is formed by the holding portion 32 and the base.

FIG. 8 shows that the sample receiver has recesses 19 in which a defined quantity of a sample can be received.

On the first container 1, a stripping device 21 is provided, which is designed as a stripper and includes a calibration hole. The stripping device 21 shown ensures that only the wells 19 are filled with the sample during insertion of the sampler provided with the sample 1 1, while excess sample material at the

Stripper 21 is retained and not in the first

Receiving space 5 passes.

Figures 9a and 9b show in detail the embodiment of the second container 2 with the second receiving space 8. Furthermore, at the open end of Container 1, the bayonet lock for connection with the first container clearly visible.

Figures 10a and 10b show an enlarged view of the closure 20, with which the second container 2 can be closed (see Figures 4a - 4c). Clearly visible here is the projection 34, which allows a closure according to the bayonet principle. The closure 20 has a

Sealing section 35 for conditioning the inside of the second container 2, which allows a media-tight closure.

The closure 17 comprises a cone-shaped sealing element 22. Figure 2c shows that the closure 17 can assume a partially opened position in which the first receiving space 5 is connected to the environment. The closure 17 has a tab 50, in which a recess 51 is arranged. The recess 51 can receive the projection 52 which is arranged on the outside of the first container 1 to form the bayonet closure 23.

In the figures (cf., in particular, 1a and 2a), the bayonet closure 23 of the first closure 17 can be clearly seen. Furthermore, the further bayonet closure 24 can be seen, with which the first container 1 is attached to the second container 2.

Figures 7a and 7b show the formed as a separate element

Bottom section 4 of the first container. These figures furthermore clearly show the filter 16 arranged therein.

FIGS. 11a-1c illustrate the introduction of a stool sample with the sample receiver 11 into the first container 1. First, the

Sampler 1 1 with a sample which adheres to this, brought into contact. Then, the sampler 1 1 is introduced with the sample in the first container 1. The stripping device 21 (see Figure 5b) ensures that the determined by the wells 19 of the sample 1 1 Quantity in the first receiving space 5 passes. After the closure 17 has been placed on the first container 1 in order to close it tightly, the sample can be dissolved in the suspension liquid (FIG. 11C) before the suspension liquid, as shown in FIGS. 2a-3c, into the second receiving space 8 is promoted.

Figures 12a-15b show further embodiments of

Devices according to the invention. The illustrated embodiments have substantial similarities with the embodiment shown in Figures 1 - 1 1 c. Therefore, for parts with

matching function below, the same reference numerals as in Figures 1 - 1 1 c used, even if the respective element is designed differently in the individual case. In addition, in order to avoid repetition, reference is made to the preceding description of the figures, which, as far as matches exist, also applies correspondingly to FIGS. 12a-15b. Below we lift the

Special features of the embodiments shown in Figures 12a -15b shown. FIGS. 12a and 12b in turn show a device for the

Preparation of a sample to be analyzed, which comprises a first and a second container 1, 2. Unlike the embodiment described above, no bayonet closure, but a screw 40 is provided for the connection of the first container 1 with the second container 2. The screw 40 is arranged in an extended region 41 of the second container 2. The configuration of the sample receiver 1 1 and the closure 17 is designed exactly as in the embodiment described above. The same goes for the

Bottom section 4 with the liquid passage thirteenth

Figures 13a and 13b show a configuration which largely corresponds to that of Figure 1 a. However, the device shown in FIGS. 13 a and 13 b is additionally provided with a securing element 46 Provided. The securing element 46 is arranged on the first and the second container 1, 2, that the first container 1 can only be detached from the second container 2 and pulled out of this, if previously the securing element 46 is removed. In the illustrated

Embodiment blocked the fuse element 46 the

Bayonet closure 24 between the first and second container 1, 2. After removal of the securing element 46, the device, as in

In connection with the figures 1 a - 1 1 c described, operated. The fuse element 46 is in the illustrated embodiment as

Safety clip formed. The fuse element 46 is a separate one

Component. To facilitate a decrease of the securing element 46, this may have a predetermined breaking point. In addition, a section of the

Fuse element 46, as shown, be designed as a tab 47, which facilitates removal of the securing element 46. The

Fuse 46 can ensure that improper handling of the device is detected. If the securing element 46 is present, the first container 1 may not have been deducted from the second container 2 yet. The embodiment illustrated in FIGS. 14a and 14b is particularly suitable for applications in which only a small amount is used

Amount of liquid is used. In particular, the

Embodiment for use in laboratories. FIGS. 14a and 14b clearly show that the second container 2 'in this embodiment is considerably shorter than the first container 1. In the illustrated

Embodiment, a total length of the second container 2 'is less than 50% of an overall length of the first container. 1 In addition, there is a difference in the configuration of the bottom section 4 of the first container 1. This has a conical outer contour. In addition, the bottom portion 7 of the second container 2 has a conical inner contour. In the bottom section 4, in turn, the fluid passage 13

formed, which may be provided with the filter 16. As in FIGS. 14a and 14b, the connection between the first and second containers 1, 2 can be made without a bayonet closure.

In the embodiment shown in Figures 15a and 15b, an outwardly projecting annular portion 48 is additionally provided on the first container 1. This facilitates handling and can be used in particular as a withdrawal aid when the first container 1 is to be moved out of the second container 2. As shown, the annular portion 48 has a radially outwardly facing knurl. At the portion 48, a projection 49 for abutment with the second container 2 is provided. The projection 49 is formed as a nose. It increases the security against rotation of the first and second containers 1, 2

to each other. A particularly good positioning is achieved when the second container 2 has a recess in which the projection 49

is included.

Claims

claims

1 . Device for the preparation of a sample to be analyzed,

in particular a stool sample, comprising a first container (1) having a first container opening (9) and a receiving space (5) for a suspension liquid (12) in which the sample is at least partially contained forms a second container (2) who a second

Container opening (10) and a second receiving space (8), wherein the first container (1) in the second receiving space (8) is at least partially receivable or received, and a Probenaufnehmer (1 1) for insertion into the first container opening (9 ), characterized in that in the first container (1)

Liquid passage (13) is formed, and that the first container (1) and the second container (2) are formed such that

Suspension liquid (12) from the first receiving space (5) in the second receiving space (8) passes when the first container (1) from the second receiving space (8) is moved out.

2. Apparatus according to claim 1, characterized in that a

Seal (14) is provided, which seals the first container (1) relative to the second container (2), that upon withdrawal of the first container (1) from the second container (2) on the

Fluid passage (13) creates a negative pressure to the

Suspension liquid from the first container (1) through the

Liquid passage (13) in the second container (2) to promote.

3. Apparatus according to claim 1 or 2, characterized in that the seal (14) comprises at least one circumferential projection which is arranged on the first and / or the second container (1, 2).

4. Device according to one of claims 1 to 3, characterized in that on the liquid passage (13), a filter (16) is arranged to to filter the suspension liquid as it passes through the fluid passage (13).

5. The device according to claim 4, characterized in that the first container (1) has a side wall (3) and a bottom portion (4), wherein the bottom portion (4) with the filter (16) arranged therein is formed by a separate element , which bears sealingly against the side wall (3).

6. Device according to one of claims 1 to 5, characterized in that the sample receiver (1 1) one or more recesses (19), in which a defined amount of the sample is receivable.

7. Device according to one of claims 1 to 6, characterized in that on the first container (1) a stripping device (21) for the

Sample receiver (1 1) is provided.

8. Device according to one of claims 1 to 7, characterized in that a closure (17) is provided to liquid-tightly close the first container opening (9), wherein the closure (17) can be brought into a partially open position, in the the first

Receiving space (8) with attached closure (17) is connected to the environment.

9. Device according to one of claims 1 to 8, characterized in that a connecting means (24) is provided to fix the first container (1) on the second container (2) when it is arranged in the second receiving space.

10. A method for preparing a sample to be analyzed, in particular a stool sample, comprising the following steps:

- Providing a device according to one of claims 1 to 9; Introducing a liquid into the first receiving space (5);

Introducing the sample into the first receiving space (5);

Mixing the sample with the liquid to produce a

Suspension liquid (12) in the first receiving space (5);

Moving out of the first container (1) from the second container (2), wherein suspension liquid (12) passes through the liquid passage (13) from the first receiving space (5) in the second receiving space (8).