EP3548041A1 - Composition pour le traitement du reflux gastro-oesophagien comprenant de l'acide hyaluronique - Google Patents
Composition pour le traitement du reflux gastro-oesophagien comprenant de l'acide hyaluroniqueInfo
- Publication number
- EP3548041A1 EP3548041A1 EP17817881.0A EP17817881A EP3548041A1 EP 3548041 A1 EP3548041 A1 EP 3548041A1 EP 17817881 A EP17817881 A EP 17817881A EP 3548041 A1 EP3548041 A1 EP 3548041A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- hyaluronic acid
- salt
- thickening agent
- natural molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 40
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 40
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- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 235000012243 magnesium silicates Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 102000006776 nephronectin Human genes 0.000 description 1
- 108010086803 nephronectin Proteins 0.000 description 1
- 108010008217 nidogen Proteins 0.000 description 1
- 210000003300 oropharynx Anatomy 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- -1 release retardants Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Definitions
- the object of the present invention is therefore to offer a practical and effective remedy, which is also well tolerated by patients, for the treatment of gastroesophageal reflux and disorders associated therewith.
- the present invention relates to a process for preparing the composition. In another aspect, the present invention relates to the use of said composition in the treatment of gastroesophageal reflux.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne une composition comprenant de l'acide hyaluronique, une molécule naturelle et des agents épaississants. Ladite composition a été démontrée pour contrer efficacement l'inconfort provoqué par le reflux gastro-oesophagien, empêcher ledit reflux et soulager les effets de celle-ci sur la muqueuse. En effet, la composition peut également jouer un rôle actif dans la régénération de tissu endommagé par le reflux précédent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102016000121617A IT201600121617A1 (it) | 2016-11-30 | 2016-11-30 | Composizione per il trattamento del reflusso gastroesofageo |
| PCT/IB2017/057293 WO2018100469A1 (fr) | 2016-11-30 | 2017-11-21 | Composition pour le traitement du reflux gastro-oesophagien comprenant de l'acide hyaluronique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP3548041A1 true EP3548041A1 (fr) | 2019-10-09 |
Family
ID=58402005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP17817881.0A Pending EP3548041A1 (fr) | 2016-11-30 | 2017-11-21 | Composition pour le traitement du reflux gastro-oesophagien comprenant de l'acide hyaluronique |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3548041A1 (fr) |
| IT (1) | IT201600121617A1 (fr) |
| WO (1) | WO2018100469A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000016531A1 (it) * | 2020-07-08 | 2022-01-08 | Italian Devices S R L | Composizioni mucoadesive e filmogene |
| IT202100011879A1 (it) * | 2021-05-10 | 2022-11-10 | Aurora Biofarma S R L | Composizione orale per il trattamento delle esofagiti |
| IT202100017528A1 (it) * | 2021-07-02 | 2023-01-02 | Ezio Abbiati | Composizione di tipo migliorato per il trattamento delle lesioni cutanee, mucosali e cartilaginee in genere |
| IT202100021992A1 (it) * | 2021-08-27 | 2023-02-27 | Neilos S R L | Composizione per la prevenzione e/o il trattamento delle patologie gastriche ed esofagee |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999063986A1 (fr) * | 1998-06-10 | 1999-12-16 | Reckitt & Colman Products Limited | Formulations pour le traitement du reflux gastro-oesophagien |
| WO2000067799A1 (fr) * | 1999-05-05 | 2000-11-16 | Reckitt Benckiser Healthcare (Uk) Limited | Compositions permettant le traitement de troubles de l'oesophage |
| WO2004073597A2 (fr) * | 2003-02-20 | 2004-09-02 | Reckitt Benckiser Healthcare (Uk) Limited | Ameliorations apportees a des compositions organiques |
| US20060040894A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid |
| US20140079814A1 (en) * | 2012-09-18 | 2014-03-20 | pH Science Holdings, Inc | Method and Composition for Treating Gastro-Esophageal Disorders |
| WO2014198605A1 (fr) * | 2013-06-14 | 2014-12-18 | Nestec S.A. | Bolus de liquide cohésif comprenant des molécules conférant une visco-élasticité |
| WO2016065083A1 (fr) * | 2014-10-21 | 2016-04-28 | Symic Biomedical, Inc. | Peptidoglycanes comprenant des peptides se fixant au collagène pour le traitement d'une lésion gastro-œsophagienne |
-
2016
- 2016-11-30 IT IT102016000121617A patent/IT201600121617A1/it unknown
-
2017
- 2017-11-21 WO PCT/IB2017/057293 patent/WO2018100469A1/fr unknown
- 2017-11-21 EP EP17817881.0A patent/EP3548041A1/fr active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999063986A1 (fr) * | 1998-06-10 | 1999-12-16 | Reckitt & Colman Products Limited | Formulations pour le traitement du reflux gastro-oesophagien |
| WO2000067799A1 (fr) * | 1999-05-05 | 2000-11-16 | Reckitt Benckiser Healthcare (Uk) Limited | Compositions permettant le traitement de troubles de l'oesophage |
| WO2004073597A2 (fr) * | 2003-02-20 | 2004-09-02 | Reckitt Benckiser Healthcare (Uk) Limited | Ameliorations apportees a des compositions organiques |
| US20060040894A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid |
| US20140079814A1 (en) * | 2012-09-18 | 2014-03-20 | pH Science Holdings, Inc | Method and Composition for Treating Gastro-Esophageal Disorders |
| WO2014198605A1 (fr) * | 2013-06-14 | 2014-12-18 | Nestec S.A. | Bolus de liquide cohésif comprenant des molécules conférant une visco-élasticité |
| WO2016065083A1 (fr) * | 2014-10-21 | 2016-04-28 | Symic Biomedical, Inc. | Peptidoglycanes comprenant des peptides se fixant au collagène pour le traitement d'une lésion gastro-œsophagienne |
Non-Patent Citations (11)
| Title |
|---|
| B PALMIERI ET AL: "Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux.", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 31 December 2013 (2013-12-31), XP055372748, Retrieved from the Internet <URL:http://www.europeanreview.org/wp/wp-content/uploads/3272-3278.pdf> [retrieved on 20170515] * |
| CASAS J?A ET AL: "Viscosity of guar gum and xanthan/guar gum mixture solutions", JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, vol. 80, no. 12, 1 January 2000 (2000-01-01), GB, pages 1722 - 1727, XP055961743, ISSN: 0022-5142, DOI: 10.1002/1097-0010(20000915)80:12<1722::AID-JSFA708>3.0.CO;2-X * |
| CEVIK MUAZEZ ET AL: "Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model", JOURNAL OF PEDIATRIC SURGERY, W. B. SAUNDERS COMPANY, US, vol. 48, no. 4, 12 April 2013 (2013-04-12), pages 716 - 723, XP028547632, ISSN: 0022-3468, DOI: 10.1016/J.JPEDSURG.2012.08.015 * |
| H.K BATCHELOR ET AL: "An in vitro mucosal model for prediction of the bioadhesion of alginate solutions to the oesophagus", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 238, no. 1-2, 1 May 2002 (2002-05-01), AMSTERDAM, NL, pages 123 - 132, XP055390591, ISSN: 0378-5173, DOI: 10.1016/S0378-5173(02)00062-5 * |
| KC KIRAN ET AL: "In Vitro Model for Studying Esophageal Epithelial Differentiation and Allergic Inflammatory Responses Identifies Keratin Involvement in Eosinophilic Esophagitis", PLOS ONE, vol. 10, no. 6, 3 June 2015 (2015-06-03), US, pages e0127755, XP093137265, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0127755 * |
| KHAN SY ET AL: "Studies on Rheological Behavior of Xanthan Gum Solutions in Presence of Additives Studies on Rheological Behavior of Xanthan Gum Solutions in Presence of Additives", PETROLEUM & PETROCHEMICAL ENGINEERING JOURNAL, 13 August 2018 (2018-08-13), XP055961501, Retrieved from the Internet <URL:https://medwinpublishers.com/PPEJ/PPEJ16000165.pdf> [retrieved on 20220915] * |
| RAMAKRISHNA CHETANA ET AL: "Rheological behavior of syrups containing sugar substitutes", EUROPEAN FOOD RESEARCH AND TECHNOLOGY, vol. 218, no. 4, 1 March 2004 (2004-03-01), pages 345 - 348, XP055086963, ISSN: 1438-2377, DOI: 10.1007/s00217-004-0876-7 * |
| See also references of WO2018100469A1 * |
| SHALU SURI ET AL: "Cell-Laden Hydrogel Constructs of Hyaluronic Acid, Collagen, and Laminin for Neural Tissue Engineering", TISSUE ENGINEERING PART A, vol. 16, no. 5, 1 May 2010 (2010-05-01), US, pages 1703 - 1716, XP055390775, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2009.0381 * |
| SNETKOV PETR ET AL: "Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer", POLYMERS, vol. 12, no. 8, 11 October 2020 (2020-10-11), CH, pages 1800, XP055961734, ISSN: 2073-4360, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/ivip/2073-4360/12/8/1800> DOI: 10.3390/polym12081800 * |
| YANG XIAO HONG ET AL: "Viscosity properties of sodium carboxymethylcellulose solutions", CELLULOSE, SPRINGER NETHERLANDS, NETHERLANDS, vol. 14, no. 5, 29 June 2007 (2007-06-29), pages 409 - 417, XP037829528, ISSN: 0969-0239, [retrieved on 20070629], DOI: 10.1007/S10570-007-9137-9 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IT201600121617A1 (it) | 2018-05-30 |
| WO2018100469A1 (fr) | 2018-06-07 |
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