EP3509956B1 - Housing for a flexible container - Google Patents
Housing for a flexible container Download PDFInfo
- Publication number
- EP3509956B1 EP3509956B1 EP18705541.3A EP18705541A EP3509956B1 EP 3509956 B1 EP3509956 B1 EP 3509956B1 EP 18705541 A EP18705541 A EP 18705541A EP 3509956 B1 EP3509956 B1 EP 3509956B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- housing
- foam
- container
- arrangement according
- flexible container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000006260 foam Substances 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000002441 reversible effect Effects 0.000 claims description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/10—Devices to locate articles in containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/16—Holders for containers
- A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/14—Linings or internal coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/02—Wrapped articles enclosed in rigid or semi-rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/06—Liquids or semi-liquids or other materials or articles enclosed in flexible containers disposed within rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/022—Containers made of shock-absorbing material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
- B65D81/107—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using blocks of shock-absorbing material
- B65D81/113—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using blocks of shock-absorbing material of a shape specially adapted to accommodate contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
Definitions
- the present invention relates to an arrangement made up of a housing and a flexible container arranged therein and filled with a liquid, in particular a drug.
- a liquid in particular a drug.
- other liquids that occur in the (bio)pharmaceutical production process can also be transported using a flexible container in such a housing.
- the DE 2258163 A1 discloses a flexible container according to the preamble of claim 1 which can be emptied while maintaining a vacuum.
- the EP 1 396 440 A1 discloses a carton in which packaging bags filled with liquid are stored. In order to cushion shocks, a thin layer of foam is provided in the box.
- Flexible containers with which medicines are transported in a housing are also referred to as “single use bags”. This is mostly done in the frozen state, with the flexible container being placed in the housing prior to freezing. The liquid is then frozen by cooling the assembly.
- the volume expansion during freezing (about 8%) creates a pressure on the housing and the flexible container that should not be underestimated. This introduces the risk of mechanical damage and consequent leakage of the mechanical container.
- the object of the present invention is to reduce the mechanical stress on the flexible container and the housing compared to the prior art when freezing.
- an elastic foam in other words: by at least one body made of elastic foam - with which the housing is lined. According to the invention, this essentially completely compensates for the volume expansion of the container arranged in the housing that occurs when it freezes.
- a housing according to the invention in which a liquid, in particular a drug, is filled into the flexible container, the filled container is placed in the housing and the liquid is frozen by cooling the assembly of housing and container.
- the flexible container does not have to be completely filled.
- Liquids that can be transported in flexible containers are e.g. B. Protein solutions, end products of a purification, antibody solutions and other high-quality intermediate products in the pharmaceutical production cycle, as well as of course drugs themselves.
- the foam has a decreasing elasticity with decreasing temperature below the freezing point. It can also be provided that the foam essentially cures at a temperature between 0°C and -30°C, preferably between -5°C and -25°C and particularly preferably between -10°C and -20°C .
- the foam is designed in such a way that the curing process is reversible.
- the elasticity of the foam is available again, thereby providing a degree of protection from impact on the flexible container when it is removed from the housing.
- the housing can in principle be reused if desired.
- the curing of the foam can also be referred to as setting. It is not a question of hardening during the production of the foam, but of changing the elasticity properties under the influence of cold.
- the housing is lined with the foam in such a way that the container—preferably including any add-on parts—is completely surrounded by the foam when the container is arranged in the housing. This means that not only the flexible container, but also the attachments can be better protected against damage.
- a foam block in the housing can be advantageous, which can accommodate the add-on parts (by deformation).
- the housing can be essentially cuboid. This can facilitate easy stacking of the housing, for example.
- the flexible container 2 is arranged inside the housing 1 .
- the housing 1 is lined with foam 3 and a foam block 5 . If the liquid within the container 2 freezes, the container 2 expands. This expansion in volume is absorbed by the foam 3 and the foam block 5, so that between the container 2 and the housing 1 no tension—or at least an insignificant tension—is created.
- Attachments 4, z. B. hoses and valves and the like are arranged above or within the foam block 5, which can accommodate them due to its elasticity or flexibility.
- the housing 1 is designed to be completely enclosing.
- the housing 1 can be made of plastic and/or metal.
- the cover layers are each made of stainless steel and the side walls are made of polyethylene (specifically: high-density polyethylene, HDPE).
- a closure or seal could also be attached, whereby manipulation during the transport process or in the warehouse can be ruled out or at least made visible.
- the foam 3 can preferably be designed in such a way that it is relatively resilient and flexible at room temperature (and low negative temperatures) and hardens at lower temperatures ( ⁇ 15° C. and colder) and encloses the container 2 arranged in the housing 1 and protects it from relative movement .
- the container 2 protected in this way cannot be bent or compressed because the movement relative to the housing 1 is prevented. As a result, breakage and leaks in the container 2 made of plastic, for example, can be prevented.
- So-called visco-elastic foam for example, can be used as the foam, which hardens at certain negative temperatures.
- housing 1 and filled container 2 can be frozen, for example, by contact cooling systems or circulating air cooling systems or in some other way.
- contact cooling systems the top surfaces of the housing 1 (also referred to as the “shell”) lie on cooled surfaces.
- circulating air cooling systems the housing 1 is flushed with cooled air.
- the individual sides of the housing 1, in particular the top surfaces (that is to say at the top and bottom), can be made of relatively thin material, in particular steel, in order to achieve rapid heat conduction (or cold conduction).
- the housing 1 according to the invention can be reused, in particular if the foam 3 is designed in such a way that curing at low temperatures is reversible.
- the housing 1 can be easily dismantled for simple recycling measures.
Description
Die vorliegende Erfindung betrifft eine Anordnung aus einem Gehäuse und einem darin angeordneten mit einer Flüssigkeit, insbesondere einem Arzneimittel, befüllten flexiblen Behälter. Neben Arzneimitteln können auch andere Flüssigkeiten, die im (bio-)pharmazeutischen Produktionsprozess auftreten, mittels eines flexiblen Behälters in einem solchen Gehäuse transportiert werden.The present invention relates to an arrangement made up of a housing and a flexible container arranged therein and filled with a liquid, in particular a drug. In addition to pharmaceuticals, other liquids that occur in the (bio)pharmaceutical production process can also be transported using a flexible container in such a housing.
Die
Die
Flexible Behälter, mit denen Arzneimittel in einem Gehäuse transportiert werden, werden auch als "single use bag" bezeichnet. Dies geschieht zumeist in gefrorenem Zustand, wobei der flexible Behälter vor dem Einfrieren im Gehäuse angeordnet wird. Durch Kühlen der Anordnung wird dann die Flüssigkeit gefroren.Flexible containers with which medicines are transported in a housing are also referred to as "single use bags". This is mostly done in the frozen state, with the flexible container being placed in the housing prior to freezing. The liquid is then frozen by cooling the assembly.
Durch die Volumenausdehnung beim Gefrieren (etwa 8 %) entsteht ein nicht zu unterschätzender Druck auf das Gehäuse und den flexiblen Behälter. Dadurch wird die Gefahr von mechanischen Beschädigungen und in der Folge Undichtigkeiten des mechanischen Behälters eingeführt.The volume expansion during freezing (about 8%) creates a pressure on the housing and the flexible container that should not be underestimated. This introduces the risk of mechanical damage and consequent leakage of the mechanical container.
Aufgabe der vorliegenden Erfindung ist es, die mechanische Beanspruchung des flexiblen Behälters und des Gehäuses gegenüber dem Stand der Technik beim Einfrieren zu verringern.The object of the present invention is to reduce the mechanical stress on the flexible container and the housing compared to the prior art when freezing.
Diese Aufgabe wird durch eine Anordnung aus einem Gehäuse und einem darin angeordneten flexiblen Behältermit den Merkmalen des Anspruchs 1 gelöst.This object is achieved by an arrangement comprising a housing and a flexible container arranged therein, having the features of
Dies geschieht durch einen elastischen Schaumstoff - anders formuliert: durch zumindest einen Körper aus elastischem Schaumstoff -, mit dem das Gehäuse ausgekleidet ist. Dieser kompensiert erfindungsgemäß die beim Gefrieren auftretende Volumenausdehnung des im Gehäuse angeordneten Behälters im Wesentlichen vollständig.This is done by an elastic foam - in other words: by at least one body made of elastic foam - with which the housing is lined. According to the invention, this essentially completely compensates for the volume expansion of the container arranged in the housing that occurs when it freezes.
Außerdem wird Schutz für die Verwendung eines erfindungsgemäßen Gehäuses begehrt, wobei eine Flüssigkeit, insbesondere ein Arzneimittel, in den flexiblen Behälter gefüllt wird, der befüllte Behälter im Gehäuse angeordnet wird und die Flüssigkeit durch Kühlen der Anordnung aus Gehäuse und Behälter eingefroren wird. Der flexible Behälter muss dabei nicht vollständig gefüllt werden.In addition, protection is sought for the use of a housing according to the invention, in which a liquid, in particular a drug, is filled into the flexible container, the filled container is placed in the housing and the liquid is frozen by cooling the assembly of housing and container. The flexible container does not have to be completely filled.
Flüssigkeiten, die im flexiblen Behälter transportiert werden können, sind z. B. Proteinlösungen, Endprodukte einer Aufreinigung, Antikörperlösungen und andere hochwertige Zwischenprodukte im pharmazeutischen Produktionszyklus, sowie natürlich Arzneimittel selbst.Liquids that can be transported in flexible containers are e.g. B. Protein solutions, end products of a purification, antibody solutions and other high-quality intermediate products in the pharmaceutical production cycle, as well as of course drugs themselves.
Vorteilhafte Ausführungsformen der Erfindung sind in den abhängigen Ansprüchen definiert.Advantageous embodiments of the invention are defined in the dependent claims.
Bevorzugt kann eine Ausführungsform sein, bei der der Schaumstoff mit abnehmender Temperatur unter dem Gefrierpunkt eine abnehmende Elastizität aufweist. Es kann auch vorgesehen sein, dass der Schaumstoff bei einer Temperatur zwischen 0° C bis -30° C, bevorzugt zwischen -5° C und -25° C und besonders bevorzugt zwischen -10° C und -20° C, im Wesentlichen aushärtet.An embodiment can be preferred in which the foam has a decreasing elasticity with decreasing temperature below the freezing point. It can also be provided that the foam essentially cures at a temperature between 0°C and -30°C, preferably between -5°C and -25°C and particularly preferably between -10°C and -20°C .
Diese Maßnahmen können dazu beitragen, dass der flexible Behälter im Gehäuse in einem genau angepassten "Bett" im Gehäuse liegt. Sämtliche auf den flexiblen Behälter und das Gehäuse einwirkende Kräfte werden dadurch durch größere Flächen aufgenommen. Beschädigungen durch Klemmung oder dergleichen werden dadurch zumindest reduziert, wenn nicht gar vollständig ausgeschlossen.These measures can contribute to the flexible container lying in a precisely adapted "bed" in the housing. All of the forces acting on the flexible container and the housing are thus absorbed by larger surfaces. As a result, damage caused by jamming or the like is at least reduced, if not completely ruled out.
In einer besonders bevorzugten Ausführungsform ist der Schaumstoff so ausgebildet, dass der Prozess des Aushärtens reversibel ist. Beim Erhöhen der Temperatur der Anordnung nach dem Transport steht somit die Elastizität des Schaumstoffs wieder zur Verfügung und bietet dadurch einen gewissen Schutz vor Einwirkungen auf den flexiblen Behälter beim Herausnehmen aus dem Gehäuse. Außerdem kann durch den reversiblen Prozess prinzipiell das Gehäuse wiederverwendet werden, wenn dies gewünscht ist.In a particularly preferred embodiment, the foam is designed in such a way that the curing process is reversible. Thus, when the temperature of the assembly is increased after shipment, the elasticity of the foam is available again, thereby providing a degree of protection from impact on the flexible container when it is removed from the housing. In addition, due to the reversible process, the housing can in principle be reused if desired.
Das Aushärten des Schaumstoffs kann auch als Festwerden bezeichnet werden. Es handelt sich dabei nicht um das Aushärten bei der Herstellung des Schaumstoffs, sondern um die Veränderung der Elastizitätseigenschaften unter der Kälteeinwirkung.The curing of the foam can also be referred to as setting. It is not a question of hardening during the production of the foam, but of changing the elasticity properties under the influence of cold.
In einer besonders bevorzugten Ausführungsform kann es vorgesehen sein, dass das Gehäuse so mit dem Schaumstoff ausgekleidet ist, dass der Behälter - vorzugsweise samt etwaiger Anbauteile - vollständig vom Schaumstoff umgeben ist, wenn der Behälter im Gehäuse angeordnet ist. Damit können nicht nur der flexible Behälter, sondern auch die Anbauteile noch besser vor Beschädigungen geschützt werden.In a particularly preferred embodiment, it can be provided that the housing is lined with the foam in such a way that the container—preferably including any add-on parts—is completely surrounded by the foam when the container is arranged in the housing. This means that not only the flexible container, but also the attachments can be better protected against damage.
Da Anbauteile für derartige flexible Behälter oft von verschiedener Form sind, weil sie beispielsweise aus verformbaren Schläuchen und dergleichen bestehen, kann ein Schaumstoffblock im Gehäuse von Vorteil sein, der die Anbauteile (durch Verformung) aufnehmen kann.Since add-on parts for such flexible containers are often of different shapes, for example because they are made of deformable hoses and the like exist, a foam block in the housing can be advantageous, which can accommodate the add-on parts (by deformation).
Das Gehäuse kann im Wesentlichen quaderförmig ausgebildet sein. Dies kann beispielsweise ein leichtes Stapeln der Gehäuse erleichtern.The housing can be essentially cuboid. This can facilitate easy stacking of the housing, for example.
Es kann auch vorkommen, dass Behälter transportiert werden müssen, die nicht vollständig befüllt worden sind. In diesem Fall kann eine zusätzliche Lage an Schaumstoff eingesetzt werden, wodurch auch in diesem Fall ein das Volumen des Gehäuses ausfüllendes "Bett" für den flexiblen Behälter geschaffen wird.It can also happen that containers have to be transported that have not been completely filled. In this case, an additional layer of foam can be used, which also creates a "bed" for the flexible container that fills the volume of the housing.
Weitere Vorteile und Einzelheiten der Erfindung ergeben sich aus den Figuren sowie der dazugehörigen Figurenbeschreibung. Dabei zeigen:
- Fig. 1
- eine geschnittene Seitenansicht eines erfindungsgemäßen Gehäuses mit darin angeordnetem flexiblen Behälter, und
- Fig. 2
- eine geschnittene Draufsicht desselben.
- 1
- a sectional side view of a housing according to the invention with a flexible container arranged therein, and
- 2
- a sectional plan view of the same.
Wie aus den
Im vorliegenden Ausführungsbeispiel ist das Gehäuse 1 vollständig umschließend ausgeführt. Das Gehäuse 1 kann aus Kunststoffen und/oder Metall bestehen. Im vorliegenden Ausführungsbeispiel sind die Deckschichten jeweils aus rostfreiem Stahl und die Seitenwände aus einem Polyethylen (konkret: high density Polyethyle, HDPE) gefertigt.In the present exemplary embodiment, the
Durch die vollkommen geschlossene Ausführung des Gehäuses 1 ist ein Zugriffsschutz auf den Behälter 2 gewährleistet. Theoretisch könnte auch ein Verschluss bzw. ein Siegel angebracht werden, wodurch eine Manipulation während des Transportprozesses oder im Lager ausgeschlossen oder zumindest sichtbar gemacht werden kann.Due to the completely closed design of the
Der Schaumstoff 3 kann vorzugsweise so ausgeführt sein, dass er bei Raumtemperatur (und geringen negativen Temperaturen) relativ nachgiebig und flexibel ist und bei tieferen Temperaturen (- 15° C und kälter) aushärtet und den im Gehäuse 1 angeordneten Behälter 2 umschließt und vor Relativbewegung schützt. Der so geschützte Behälter 2 kann demnach nicht verbogen oder gestaucht werden, weil die Relativbewegung zum Gehäuse 1 ja verhindert ist. Dadurch können Brüche und Leckagen am beispielsweise aus Kunststoff gefertigten Behälter 2 verhindert werden.The
Als Schaumstoff kann beispielsweise sogenannter visko-elastischer Schaum eingesetzt werden, welcher bei gewissen negativen Temperaturen aushärtet.So-called visco-elastic foam, for example, can be used as the foam, which hardens at certain negative temperatures.
Das Einfrieren der Anordnung aus Gehäuse 1 und befülltem Behälter 2 kann beispielsweise durch Kontaktkühlanlagen oder Umluftkühlanlagen oder auf andere Art geschehen. Bei Kontaktkühlanlagen liegen die Deckflächen des Gehäuses 1 (auch als "Schale" bezeichnet) an gekühlten Flächen auf. Bei Umluftkühlanlagen werden die Gehäuse 1 mit gekühlter Luft umspült.The arrangement of
Die einzelnen Seiten des Gehäuses 1, insbesondere die Deckflächen (also oben und unten), können aus relativ dünnem Material, insbesondere Stahl, hergestellt sein, um eine schnelle Wärmeleitung (bzw. Kälteleitung) zu erreichen.The individual sides of the
Die erfindungsgemäßen Gehäuse 1 können - wie bereits erwähnt - wiederverwendet werden, insbesondere, wenn der Schaumstoff 3 so ausgebildet ist, dass das Aushärten bei niedrigen Temperaturen reversibel ist. Natürlich ist auch eine Einfach-Verwendung des Gehäuses 1 denkbar. Hierfür kann das Gehäuse 1 für einfache Recycling-Maßnahmen leicht zu zerlegen sein.As already mentioned, the
Claims (9)
- Arrangement comprising a housing (1) and a flexible container (2) arranged therein filled with a liquid, in particular a medicine, wherein the housing (1) is at least partially lined with an elastic foam (3, 5), characterized in that the housing (1) is lined with the foam (3, 5) in such a way that an increase in volume of the container (2) arranged in the housing (1) that occurs upon freezing is substantially completely compensated by the foam (3, 5).
- Arrangement according to claim 1 characterised in that the foam (3, 5) has a decreasing elasticity with decreasing temperature below the freezing point.
- Arrangement according to one of the preceding claims characterised in that the foam (3, 5) is chosen in such a way that it substantially hardens at a temperature between 0°C to -30°C, preferably between - 5°C and -25°C and particularly preferably between -10°C and -20°C.
- Arrangement according to claim 3 characterised in that the foam is chosen in such a way that the hardening process is reversible.
- Arrangement according to one of the preceding claims characterised in that the housing (1) is lined with the foam (3, 5) in such a way that the container (2) - preferably together with any attachments (4) - is completely surrounded by the foam (3, 5) when the container (2) is arranged in the housing (1).
- Arrangement according to claim 5 characterised in that a foam block (5) is provided in the housing (1) for receiving the attachments (4).
- Arrangement according to one of the preceding claims characterised in that the housing (1) is of a substantially cuboidal shape.
- Use of an arrangement according to one of claims 1 to 7 wherein a liquid, in particular a medicine, is put into the flexible container (2), the filled container (2) is arranged in the housing (1) and the liquid is cooled by cooling the arrangement comprising the housing (1) and the container (2).
- Use according to claim 8 characterised in that at least one additional layer of foam (3, 5) is arranged in the container (2) when the flexible container (2) is filled only to a part of its capacity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP22153960.4A EP4032824A1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT600042017 | 2017-01-16 | ||
ATGM50100/2017U AT15857U1 (en) | 2017-01-16 | 2017-05-24 | Housing for a flexible container |
PCT/AT2018/060010 WO2018129576A1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22153960.4A Division-Into EP4032824A1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
EP22153960.4A Division EP4032824A1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3509956A1 EP3509956A1 (en) | 2019-07-17 |
EP3509956B1 true EP3509956B1 (en) | 2022-03-09 |
Family
ID=62839098
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22153960.4A Pending EP4032824A1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
EP18705541.3A Active EP3509956B1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22153960.4A Pending EP4032824A1 (en) | 2017-01-16 | 2018-01-15 | Housing for a flexible container |
Country Status (5)
Country | Link |
---|---|
US (3) | US11207239B2 (en) |
EP (2) | EP4032824A1 (en) |
CN (1) | CN109890716B (en) |
DK (1) | DK3509956T3 (en) |
WO (1) | WO2018129576A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT521596A1 (en) | 2018-09-05 | 2020-03-15 | Single Use Support Gmbh | Cooling plate assembly and method |
CN112955007A (en) * | 2018-11-12 | 2021-06-11 | 斯玛特弗雷兹有限公司 | Thermal insulation for preventing damage and rupture of containers caused by freezing aqueous solutions containing biological materials |
EP3926277A1 (en) | 2020-06-19 | 2021-12-22 | Single Use Support GmbH | Plate freezer |
EP3964453A1 (en) | 2020-09-02 | 2022-03-09 | Single Use Support GmbH | Container for receiving a bag, method and usage |
EP4014947A1 (en) | 2020-12-16 | 2022-06-22 | Single Use Support GmbH | Method for protecting tubing |
EP4166884A1 (en) | 2021-10-15 | 2023-04-19 | Single Use Support GmbH | Cooling plate and method for manufacturing a cooling plate |
EP4169499A1 (en) | 2021-10-19 | 2023-04-26 | Single Use Support GmbH | Method and device for cooling or heating bio-pharmaceutical fluids |
Family Cites Families (19)
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DE2258163C3 (en) * | 1972-11-28 | 1975-05-28 | Fridolin 7717 Immendingen Wais | Device for sterile filling, pressure-proof storage and handling as well as for any frequency with which liquids are withdrawn |
NL8501555A (en) * | 1985-05-30 | 1986-12-16 | Nutricia Nv | Material package for medical tube feeding - comprises flexible plastics vessel in box enclosed by laminar material forming barrier |
US4723974A (en) * | 1985-07-26 | 1988-02-09 | Ammerman Stephen W | Transporting container for an amputated extremity |
US4738364A (en) * | 1987-03-24 | 1988-04-19 | Medicool, Inc. | Portable medicine protector |
IT220372Z2 (en) * | 1989-04-03 | 1993-09-20 | Qts Srl | PORTABLE THERMAL CONTAINER FOR INSULIN AMPOULES AND OTHER MATERIALS REQUIRED FOR INJECTIONS WITH DIABETICS AND SIMILAR MEDICINAL PRODUCTS. |
US6401484B2 (en) * | 1999-09-30 | 2002-06-11 | Gano, Iii John Henry | Transport container |
US6554133B1 (en) * | 2000-07-11 | 2003-04-29 | Hewlett-Packard Development Company, L.P. | Container package for packaging electronic devices including multimedia devices such as entire computer system including a computer case, a monitor, and a printer |
US6381981B1 (en) * | 2001-05-02 | 2002-05-07 | Advanced Tissue Sciences, Inc. | Container for shipping and storing frozen products |
GB2383402A (en) * | 2001-08-10 | 2003-06-25 | Adrian Peter Copeland | Heat-insulated container |
DE10155150C2 (en) | 2001-11-12 | 2003-09-11 | Ghassan Sowan | Mailing bag for thermally sensitive material and the transport packaging built up with it |
EP1396440A1 (en) * | 2002-09-05 | 2004-03-10 | The Procter & Gamble Company | Packaged product comprising flexible, liquid-filled pouches |
US7278278B2 (en) * | 2003-06-12 | 2007-10-09 | 21St Century Medicine, Inc. | Cryogenic storage system |
US7240513B1 (en) * | 2004-04-12 | 2007-07-10 | Conforti Carl J | Thermally-controlled package |
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US9950830B2 (en) * | 2007-04-23 | 2018-04-24 | Coldkeepers, Llc | Insulated liners and containers |
US9301520B2 (en) * | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
US8177123B2 (en) * | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
US20150305978A1 (en) * | 2012-11-20 | 2015-10-29 | Ohio State Innovation Foundation | Insulation device for blood bag |
CN203959080U (en) * | 2014-05-22 | 2014-11-26 | 青岛市中心医院 | Temperature-constant transfusion bag catcher |
-
2018
- 2018-01-15 EP EP22153960.4A patent/EP4032824A1/en active Pending
- 2018-01-15 WO PCT/AT2018/060010 patent/WO2018129576A1/en unknown
- 2018-01-15 CN CN201880003960.XA patent/CN109890716B/en active Active
- 2018-01-15 DK DK18705541.3T patent/DK3509956T3/en active
- 2018-01-15 EP EP18705541.3A patent/EP3509956B1/en active Active
-
2019
- 2019-04-02 US US16/373,177 patent/US11207239B2/en active Active
-
2021
- 2021-10-22 US US17/508,008 patent/US11602487B2/en active Active
-
2023
- 2023-01-10 US US18/095,082 patent/US20230157928A1/en active Pending
Non-Patent Citations (1)
Title |
---|
None * |
Also Published As
Publication number | Publication date |
---|---|
US20220047457A1 (en) | 2022-02-17 |
US11207239B2 (en) | 2021-12-28 |
EP3509956A1 (en) | 2019-07-17 |
CN109890716A (en) | 2019-06-14 |
US20230157928A1 (en) | 2023-05-25 |
US11602487B2 (en) | 2023-03-14 |
CN109890716B (en) | 2022-04-26 |
DK3509956T3 (en) | 2022-04-11 |
WO2018129576A1 (en) | 2018-07-19 |
US20190224074A1 (en) | 2019-07-25 |
EP4032824A1 (en) | 2022-07-27 |
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