EP4166884A1 - Cooling plate and method for manufacturing a cooling plate - Google Patents
Cooling plate and method for manufacturing a cooling plate Download PDFInfo
- Publication number
- EP4166884A1 EP4166884A1 EP21202961.5A EP21202961A EP4166884A1 EP 4166884 A1 EP4166884 A1 EP 4166884A1 EP 21202961 A EP21202961 A EP 21202961A EP 4166884 A1 EP4166884 A1 EP 4166884A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- component part
- recess
- cooling
- cooling plate
- hook
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000001816 cooling Methods 0.000 title claims abstract description 131
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 17
- 239000007788 liquid Substances 0.000 claims description 19
- 239000000853 adhesive Substances 0.000 claims description 16
- 230000001070 adhesive effect Effects 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 6
- 229960000074 biopharmaceutical Drugs 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 238000010257 thawing Methods 0.000 claims description 3
- 239000002826 coolant Substances 0.000 description 8
- 230000007797 corrosion Effects 0.000 description 6
- 238000005260 corrosion Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000003466 welding Methods 0.000 description 3
- 238000003801 milling Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229930091051 Arenine Natural products 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D31/00—Other cooling or freezing apparatus
- F25D31/001—Plate freezers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F3/00—Plate-like or laminated elements; Assemblies of plate-like or laminated elements
- F28F3/12—Elements constructed in the shape of a hollow panel, e.g. with channels
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
- F28D1/00—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators
- F28D1/02—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid
- F28D1/03—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid with plate-like or laminated conduits
- F28D1/0308—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid with plate-like or laminated conduits the conduits being formed by paired plates touching each other
- F28D1/035—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid with plate-like or laminated conduits the conduits being formed by paired plates touching each other with U-flow or serpentine-flow inside the conduits
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2275/00—Fastening; Joining
- F28F2275/02—Fastening; Joining by using bonding materials; by embedding elements in particular materials
- F28F2275/025—Fastening; Joining by using bonding materials; by embedding elements in particular materials by using adhesives
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2275/00—Fastening; Joining
- F28F2275/06—Fastening; Joining by welding
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2275/00—Fastening; Joining
- F28F2275/14—Fastening; Joining by using form fitting connection, e.g. with tongue and groove
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
- F28F2275/00—Fastening; Joining
- F28F2275/20—Fastening; Joining with threaded elements
Definitions
- the present invention concerns a cooling plate, a cooling device, a use of a cooling plate, and a method for manufacturing a cooling plate.
- Cooling plates are used in cooling devices, for example for cooling and freezing liquids occurring in or resulting from a bio-pharmaceutical production process.
- the resulting frozen liquid which represents a sizeable monetary value, can afterwards be transported or stored in such a way that the frozen liquid is protected from damage, stemming for example from mechanical impacts, and potentially resulting loss of sterile integrity.
- cooling plates for cooling liquids or other goods with a liquid content are also known from other areas, for example from the food industry.
- cooling plates include at least one cooling channel for a cooling medium which is disposed inside a plate body.
- the liquid to be cooled is placed adjacent to a cooling plate or between cooling plates, and a cooling medium of lower temperature than the liquid is pumped through the at least one cooling channel. Heat from the liquid is then conducted into the cooling medium, thereby cooling the liquid.
- a cooling device making use of cooling plates for use in the bio-pharmaceutical production process is known from unpublished European Patent Application no. 20181117.1 or from WO 2020/047571 A1 .
- Containers for liquids occurring in or resulting from a bio-pharmaceutical production process and which are adapted for freezing in a cooling device are known from WO 2018/129576 A1 .
- Cooling plates according to the prior art are for example manufactured by providing two steel sheets which are connected at their periphery by distance panels, e.g. by welding, such that a plate-like shape results.
- the cooling channel is realised by further panels which are welded into the inside in such a way as to create a meandering channel.
- a further problem is deformation of the surface of the cooling plate because it is difficult to weld the different panels with high enough accuracy such that the surfaces of the cooling plate are plane enough.
- a surface of the cooling plate which is as plane as possible is of course desired, because the larger the contact area between the cooling plate and the container of the liquid to be cooled is the better the heat transfer between the container and the cooling plate will be. Therefore, a cooling plate with precise geometrical shape directly contributes to an effective cooling.
- the object of the invention is therefore to provide a cooling plate and a method for manufacturing a cooling plate, wherein the properties regarding liquid tightness for the cooling medium, corrosion, and/or precise geometrical shape are improved compared to the prior art.
- a cooling plate with a plate body and at least one cooling channel which is disposed inside the plate body and which is at least partly delimited by the plate body, wherein the plate body comprises
- the object is achieved by a method according to claim 12, the method comprising the following steps:
- the invention provides a cooling plate and a method for manufacturing the same from significantly fewer component parts than in the prior art. Furthermore, the at least one cooling channel is easily delimited (at least in part) by two parts which are made up of full or mainly full material (i.e. reduced or no hollowness), such that potential leaks and corrosion automatically become much less likely.
- first part and the second part from full material blanks allows for much better geometrical precision of the cooling plate compared to a welded construction made up of sheet metal.
- the first component part can realise a first plane (i.e. flat) surface of the plate body and/or the second component part can realise a second plane (i.e. flat) surface of the plate body.
- first plane i.e. flat
- second plane i.e. flat
- the first component part and the second component part can preferably interface along a surface which is substantially parallel to the first plane surface and/or the second plane surface.
- the plate body is preferably of a plate-like base shape, preferably with a rectangular base area.
- the cooling plate could also have a different base shape, for example as a curved or bent plate-like shape.
- the at least one first recess and the at least one second recess can each be divided into separate recesses, which are themselves contiguous, resulting in more than one cooling channel which are at least in part delimited by the separate first and second recesses.
- the at least one first recess and/or the at least one second recess can each be a single contiguous recess.
- the at least one cooling channel can be of circular cross-section. However, in particularly preferred embodiments the at least one cooling channel are somewhat flattened with flat inner surfaces parallel to the first plane surface and/or the second plane surface of the cooling plate.
- the at least one cooling channel can lead through the plate body in a meandering manner of fashion in order to cover as much of the area of the cooling plate and in order to achieve a heat transfer which is as homogeneous over the area of the cooling plate.
- the first component part and the second component part are attached to each other such that the at least one first recess and the at least one second recess face each other and such that the at least one first recess and the at least one second recess together realise at least part of the at least one cooling channel inside the plate body.
- one side of the cross section is given by the at least one first recess and the other side of the cross section is given by the at least one second recess.
- the at least one first recess and the at least one second recess are arranged on top of each other such that material around the recesses together delimits the at least one cooling channel.
- first blank body and the second blank body which are furnished with the first recess and the second recess can be made of full material blank bodies.
- the first component part, the second component part, the first blank body, and/or the second blank body can preferably be made of stainless steel.
- the at least one first recess and/or the at least one second recess can preferably be formed into the first blank body and/or the second blank body, respectively, by a cutting method in the engineering sense, in particular milling.
- first recess and the second recess correspond to each other geometrically does not necessarily mean that they have to be of equal geometrical shape. That the first recess and the second recess correspond to each other geometrically can interpreted in the sense that they are able to together delimit the at least one cooling channel in a state where the first component part and the second component part are attached to each other.
- Protected is also a cooling device comprising at least one cooling plate according to the invention.
- the cooling plate according to the invention or the cooling device according to the invention can both be used for cooling, in particular freezing, and for heating, in particular thawing, liquids or goods containing a liquid component.
- the cooling or heating is achieved by arranging the liquids or goods to be cooled or heated adjacent to the cooling plate according to the invention or between cooling plates according to the invention, and supplying a cooling or heating medium of higher or lower temperature than the liquids or goods, respectively, to the cooling plate(s).
- Protected is furthermore a use of a cooling plate according to the invention or a cooling device according to the invention in cooling, in particular freezing, and/or heating, in particular thawing, a liquid occurring in and/or resulting from a pharmaceutical production process, in particular a bio-pharmaceutical production process.
- a cooling plate according to the invention can be particularly advantageous as leaks, corrosion, as well as inhomogeneous or ineffective heat transfer can have a quite detrimental effect due to the valuable nature of the liquids to be frozen or thawed.
- the first component part and the second component part can be attached to each other with at least one mechanical connection and/or at least one adhesive bond.
- the at least one mechanical connection can be embodied as at least one thread and screw connection and/or at least one positive lock connection.
- a screw head of the at least one thread and screw connection is welded substantially flat, and a remaining substantially flat surface is polished and/or sanded.
- the screw head of a thread and screw connection can disturb the surfaces of the cooling plate, which as already mentioned contributes to an efficient heat transfer.
- welding the screw head flat e.g. by removing part of the screw head and/or filling a central recess of the screw head, can therefore be beneficial for a substantially flat or (first or second) plane surface of the cooling plate. This can be further improved by sanding and/or polishing the remaining surface.
- first and/or second plane surface can also be polished and/or sanded independently of the presence of a thread and screw connection.
- Positive lock connections are connections which fasten two component parts, here the first component part and the second component part, to each other by way of the shape of the objects or geometrical features realising the connection (in contrast to a frictional connection or a force closure).
- the at least one positive lock connection can comprise a hook component part (preferably more than one hook component part) which is separate from the first component part and/or the second component part, wherein the hook component part includes a first hook element and/or a second hook element, and wherein the first hook element is engaged with a first undercut in the first component part and/or the second hook element is engaged with a second undercut in the second component part.
- a hook component part preferably more than one hook component part
- hook component part and "hook elements” here are not be understood narrowly so as to have to have a shape of a commonly known hook.
- hooks should merely be understood as geometrical features which cooperate with an undercut or the like in order to achieve a positive lock.
- the hook component part and/or the first hook element and/or the second hook element can for example be embodied as a T-shaped sliding element cooperating with an undercut (in particular if viewed in a cross section).
- the hook component part can be embodied as double T-shaped sliding elements (T-shapes on opposing sides).
- the hook component part and/or the first hook element and/or the second hook element could also incorporate a conical shape instead of a (double) T-shape (in particular if viewed in a cross section).
- the hook component part can preferably be arranged on an inside of the plate body, i.e. not on the periphery of the plate body.
- the method according to the invention further comprises attaching the first component part and the second component part to each other using a positive lock connection, preferably additionally comprising
- Such embodiments can preferably additionally comprise engaging the first hook element with the undercut in the first component part, bringing the second component part into contact with the first component part, and moving the second component part relative to the first component part laterally along an interface between the first component part and the second component part until the second hook element of the hook component part engages with the second undercut of the second component part, or vice versa.
- a force closure can additionally be present when the second component part is moved laterally along the interface with the first component part (or vice versa). Then the first and second component parts are secured on the one hand against unwanted relative lateral movements by the force closure, and potentially another mechanical connection and/or adhesive bond, and are secured on the other hand against unwanted relative axial movements (i.e. parallel to a normal direction on the surface of the cooling plate) by the positive lock connection, and potentially another mechanical connection and/or adhesive bond.
- the at least one adhesive bond can for example be a metallic continuity bond, in particular a welded bond.
- Other adhesive bonds, for example with an adhesive substance (glue) are of course in principle conceivable.
- the first component part and the second component part can be bonded to each other through the adhesive bond along at least one peripheral side, preferably all peripheral sides, of the first component part and the second component part.
- first component part and the second component part are attached to each other by at least one positive lock connection, preferably with at least one hook component part as described before, and an adhesive bond, in particular a weld, wherein there is preferably no thread and screw connection.
- the at least one positive lock connection can be arranged in a central portion of the cooling plate and the adhesive bond is arranged around the peripheral sides of the cooling plate.
- the adhesive bond is arranged around the peripheral sides of the cooling plate.
- the cooling plates can have side lengths between 500mm and 1500mm, preferably between 700mm and 1200mm, and particularly preferably between 800mm and 1100mm.
- FIG. 1 shows an exemplary embodiment of a cooling plate 1 according to the invention.
- a plate body 2 of the cooling plate 1 comprises an internal cooling channel 3 (see Figures 3a, 3b and 6 ).
- Ports 19 can be used to connect tubing or piping for conveying a cooling medium through the at least one cooling channel 3.
- Silicone oil can be used as cooling (or heating) medium.
- the cooling plate 1 has dimensions of approximately 1074mm by 850mm.
- Fig. 2a, 2b, 3a, 3b, 4a, 4b, 5, and 6 schematically show steps of an embodiment of a manufacturing method for cooling plates 1 according to the invention.
- a first blank body 17 and a second blank body 18 are provided ( Fig. 2a and 2b , shown in top view).
- the blank bodies can for example be made of stainless steel.
- the blank bodies could be made of Aluminium or (other) materials which offer high heat transfer, resistance to corrosion and impermeability for a cooling or heating medium.
- the first blank body 17 and/or the second blank body 18 can be of substantially cuboidal base shape.
- the blank bodies are of substantially plate-like base shape, i.e. a height of the blank bodies may be much smaller than a width and a length of the blank bodies.
- the width and length are different from each other.
- embodiments with equal lengths and widths are in principle conceivable. Since the first blank body 17 and the second plate body 18 eventually make up the plate body 2, analogous statements are true for the plate body 2.
- At least one first recess 5 is formed in the first blank body 17 and at least one recess 7 is formed in the second blank body 18 ( Fig. 3a and 3b ), such that the first recess 5 and the second recess 7 correspond to each other geometrically.
- first blank body 17 becomes the first component part 4
- the second blank body 18 becomes the second component part 6.
- first recess 5 and the second recess 7 are depicted as geometrically substantially equal in Fig. 3a and 3b .
- first recess 5 and the second recess 7 can be of different geometrical shape while still able to together delimit the at least one cooling channel 3 in a state where the first component part 4 and the second component part 6 are attached to each other, as laid out previously.
- openings 20 can be formed into the first blank body 17 and/or the second blank body 18, which later allow attachment of the first component part 4 and the second component part 6 to each other.
- the forming of the first recess 5 and/or the second recess 7 and/or the openings 20 can be performed with a machining process, in particular a milling process.
- Fig. 4a and 4b (as well as Fig. 5 and 6 ) show the first component part 4 and the second component part 6 in a sectional view through the planes A indicated in Fig. 3a and 3b .
- first component part 4 and the second component part 6 are brought together with the sides comprising the first recess 5 and the second recess 7 facing each other at an interface ( Fig. 5 ).
- the first component part 4 and the second component part 6 are then attached to each other in this configuration.
- first component part 4 and the second component part 6 together become the plate body 2 of the cooling plate 1.
- the first component part 4 creates a first plane surface 15 of the plate body 2 and the second component part 6 creates a second plane surface 16 of the plate body 2.
- Attaching the first component part 4 and the second component part 6 to each other can for example be achieved using a positive lock, such as described in connection with Fig. 9 to 11 below, and/or a screw and thread connection, such as described in connection with Fig. 12 to 14 below, realising a mechanical connection.
- a positive lock such as described in connection with Fig. 9 to 11 below
- a screw and thread connection such as described in connection with Fig. 12 to 14 below
- first component part 4 and the second component part 6 can be attached to each other using an adhesive bond.
- first component part 4 and the second component part 6 can be welded to each other along the welded bond 14 depicted in Fig. 6 .
- an adhesive or the like can be used in order to facilitate the adhesive bond.
- Fig. 7 and 8 schematically depict a hook component part 9 which can be used to attach the first component part 4 and the second component part 6 to each other using one or more positive lock connections.
- Fig. 8 shows the hook component part 9 on its own. It comprises two first hook elements 11 and two second hook elements 12 on opposite sides. It would also be possible to only use one first hook element 11 and/or only one second hook element 12, or more than two of either.
- Fig. 7 shows the hook component part 9 hooked into the first component part 4 (the first component part 4 being depicted in a cutaway view).
- Several of these hook component parts 9 can be used for attaching the first component part 4 and the second component part 6 to each other (or a single one).
- the openings 20 in the first component part 4 and the second component part 6 have a wider area and a narrower area, where the narrower areas each comprise a first undercut 13 or a second undercut.
- the hook component parts 9 can be inserted into the wider area of the openings 20 and moved laterally into the narrower area such that the first hook elements 11 move under the first undercuts 13.
- a vertical movement of the hook component part 9 away from the first component part 4 is then impeded by the first undercut 13.
- the second component part 6 comprises second undercuts (not shown) through which the hook component parts 9 can be hooked into the second component part 6.
- the second undercuts can be embodied substantially equal to the first undercuts 13.
- the attachment operation for attaching the first component part 4 to the second component part 6 using the hook component part 9 is shown schematically in Fig. 9 to 11 .
- Fig. 9 shows the first component part 4 with the hook component parts 9 in the hooked state as shown in Fig. 7 .
- the first component part 4 and the second component part 6 are then brought into contact with each other with a lateral offset as depicted in Fig. 10 .
- the hook component parts 9 are thereby inserted into the wider areas of the openings 20 of the second component part 6 (see Fig. 3b ).
- an additional adhesive bond (like for example a welded connection) can then be used to inhibit also lateral movement so that the first component part 4 and the second component part 6 are completely fixed to each other.
- Fig. 12 to 14 schematically show an example where the first component part 4 and the second component part 6 are attached to each other using a screw and thread connection.
- the first component part 4 and the second component part 6 are provided ( Fig. 12 ), brought into contact with each other and screws are used to fix the first component part 4 and the second component part 6 to each other ( Fig. 13 ).
- screw heads 8 may protrude from the first plane surface 15 or the second plane surface 16.
- the screw heads 8 can then be welded substantially flat by removing the protruding parts of the screw heads 8 and/or filling up recesses in the screw heads 8 (build-up welding) resulting in the configuration depicted schematically in Fig. 14 .
- the first plane surface 15 and/or the second plane surface 16 can be polished or sanded in order to achieve a desired surface smoothness or surface structure.
- Fig. 15 shows the embodiment of the cooling plate 1 of Fig. 1 which was manufactured with the methods as described in connection with Fig. 2a, 2b, 3a, 3b, 4a, 4b, 5, 6 , 7, 8 , 9, 10, and 11 .
- a total of 28 hook component parts 9 have been used in a grid-like arrangement as indicated in Fig. 15 .
- Fig. 16 shows the embodiment of Fig. 15 in a sectional view through a plane parallel to the first plane surface 15 and/or the second plane surface 16.
- the layout of the cooling channel 3 in this embodiment is visible in Fig. 16 .
- Fig. 17 shows an example of a cooling device 10 with cooling plates 1 according to the invention. In this embodiment there are nine cooling plates 1 according to the invention.
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- Thermal Sciences (AREA)
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Abstract
- a first component part (4) with a at least one first recess (5), and
- a second component part (6) with at least one second recess (7), which second recess (7) geometrically corresponds to the first recess (5),
wherein the first component part (4) and the second component part (6) are attached to each other such that the at least one first recess (5) and the at least one second recess (7) face each other and such that the at least one first recess (5) and the at least one second recess (7) together realise at least part of the at least one cooling channel (3) inside the plate body (2).
Description
- The present invention concerns a cooling plate, a cooling device, a use of a cooling plate, and a method for manufacturing a cooling plate.
- Cooling plates are used in cooling devices, for example for cooling and freezing liquids occurring in or resulting from a bio-pharmaceutical production process. The resulting frozen liquid, which represents a sizeable monetary value, can afterwards be transported or stored in such a way that the frozen liquid is protected from damage, stemming for example from mechanical impacts, and potentially resulting loss of sterile integrity.
- In and of themselves, cooling plates for cooling liquids or other goods with a liquid content are also known from other areas, for example from the food industry.
- In the prior art, cooling plates include at least one cooling channel for a cooling medium which is disposed inside a plate body. The liquid to be cooled is placed adjacent to a cooling plate or between cooling plates, and a cooling medium of lower temperature than the liquid is pumped through the at least one cooling channel. Heat from the liquid is then conducted into the cooling medium, thereby cooling the liquid.
- A cooling device making use of cooling plates for use in the bio-pharmaceutical production process is known from unpublished
European Patent Application no. 20181117.1 WO 2020/047571 A1 . Containers for liquids occurring in or resulting from a bio-pharmaceutical production process and which are adapted for freezing in a cooling device are known fromWO 2018/129576 A1 . - Cooling plates according to the prior art are for example manufactured by providing two steel sheets which are connected at their periphery by distance panels, e.g. by welding, such that a plate-like shape results. The cooling channel is realised by further panels which are welded into the inside in such a way as to create a meandering channel.
- This has several disadvantages. Because of the many welds there is a large chance that one of the welds is not liquid-tight, such that leakage of the cooling medium is a regular occurrence. Such configurations also often suffer from corrosion.
- A further problem is deformation of the surface of the cooling plate because it is difficult to weld the different panels with high enough accuracy such that the surfaces of the cooling plate are plane enough. However, a surface of the cooling plate which is as plane as possible is of course desired, because the larger the contact area between the cooling plate and the container of the liquid to be cooled is the better the heat transfer between the container and the cooling plate will be. Therefore, a cooling plate with precise geometrical shape directly contributes to an effective cooling.
- The object of the invention is therefore to provide a cooling plate and a method for manufacturing a cooling plate, wherein the properties regarding liquid tightness for the cooling medium, corrosion, and/or precise geometrical shape are improved compared to the prior art.
- Regarding the cooling plate this object is achieved with the features of
claim 1, namely by a cooling plate with a plate body and at least one cooling channel which is disposed inside the plate body and which is at least partly delimited by the plate body, wherein the plate body comprises - a first component part with a at least one first recess, and
- a second component part with at least one second recess, which second recess geometrically corresponds to the first recess,
- Regarding the method the object is achieved by a method according to
claim 12, the method comprising the following steps: - forming at least one first recess into a first blank body yielding a first component part,
- forming at least one second recess into a second blank body yielding a second component part, such that the at least one second recess geometrically corresponds to the at least one first recess,
- attaching the first component part and the second component part to each other such that the at least one first recess and the at least one second recess face each other and such that the at least one first recess and the at least one second recess together realise at least part of the at least one cooling channel inside a plate body of the cooling plate.
- The invention provides a cooling plate and a method for manufacturing the same from significantly fewer component parts than in the prior art. Furthermore, the at least one cooling channel is easily delimited (at least in part) by two parts which are made up of full or mainly full material (i.e. reduced or no hollowness), such that potential leaks and corrosion automatically become much less likely.
- Furthermore, forming the first part and the second part from full material blanks allows for much better geometrical precision of the cooling plate compared to a welded construction made up of sheet metal.
- The first component part can realise a first plane (i.e. flat) surface of the plate body and/or the second component part can realise a second plane (i.e. flat) surface of the plate body. In other embodiments there can of course also be surfaces of the cooling plate with protrusions or other surface geometries as desired for the particular application.
- The first component part and the second component part can preferably interface along a surface which is substantially parallel to the first plane surface and/or the second plane surface.
- The plate body is preferably of a plate-like base shape, preferably with a rectangular base area. Of course, there can be other features present, such as fastenings for fastening the cooling plates in a cooling device and/or ports for connecting conducts for the cooling medium to the at least one cooling channel, such that cooling medium can be supplied to and discharged from the at least one cooling channel. The cooling plate could also have a different base shape, for example as a curved or bent plate-like shape.
- There can be one or more cooling channels delimited at least partly by the first component part and the second component part. In particular, the at least one first recess and the at least one second recess can each be divided into separate recesses, which are themselves contiguous, resulting in more than one cooling channel which are at least in part delimited by the separate first and second recesses. Of course, the at least one first recess and/or the at least one second recess can each be a single contiguous recess.
- The at least one cooling channel can be of circular cross-section. However, in particularly preferred embodiments the at least one cooling channel are somewhat flattened with flat inner surfaces parallel to the first plane surface and/or the second plane surface of the cooling plate.
- The at least one cooling channel can lead through the plate body in a meandering manner of fashion in order to cover as much of the area of the cooling plate and in order to achieve a heat transfer which is as homogeneous over the area of the cooling plate.
- According to the invention the first component part and the second component part are attached to each other such that the at least one first recess and the at least one second recess face each other and such that the at least one first recess and the at least one second recess together realise at least part of the at least one cooling channel inside the plate body.
- Formulated differently, viewed in a cross-section of the at least one cooling channel one side of the cross section is given by the at least one first recess and the other side of the cross section is given by the at least one second recess. In yet other words, the at least one first recess and the at least one second recess are arranged on top of each other such that material around the recesses together delimits the at least one cooling channel.
- As mentioned before, the first blank body and the second blank body which are furnished with the first recess and the second recess can be made of full material blank bodies.
- The first component part, the second component part, the first blank body, and/or the second blank body can preferably be made of stainless steel.
- The at least one first recess and/or the at least one second recess can preferably be formed into the first blank body and/or the second blank body, respectively, by a cutting method in the engineering sense, in particular milling.
- That the first recess and the second recess correspond to each other geometrically does not necessarily mean that they have to be of equal geometrical shape. That the first recess and the second recess correspond to each other geometrically can interpreted in the sense that they are able to together delimit the at least one cooling channel in a state where the first component part and the second component part are attached to each other.
- Protected is also a cooling device comprising at least one cooling plate according to the invention.
- It should be noted that the cooling plate according to the invention or the cooling device according to the invention can both be used for cooling, in particular freezing, and for heating, in particular thawing, liquids or goods containing a liquid component. The cooling or heating is achieved by arranging the liquids or goods to be cooled or heated adjacent to the cooling plate according to the invention or between cooling plates according to the invention, and supplying a cooling or heating medium of higher or lower temperature than the liquids or goods, respectively, to the cooling plate(s).
- Protected is furthermore a use of a cooling plate according to the invention or a cooling device according to the invention in cooling, in particular freezing, and/or heating, in particular thawing, a liquid occurring in and/or resulting from a pharmaceutical production process, in particular a bio-pharmaceutical production process.
- For these applications a cooling plate according to the invention can be particularly advantageous as leaks, corrosion, as well as inhomogeneous or ineffective heat transfer can have a quite detrimental effect due to the valuable nature of the liquids to be frozen or thawed.
- Further advantageous embodiments are defined in the dependent claims.
- The first component part and the second component part can be attached to each other with at least one mechanical connection and/or at least one adhesive bond.
- The at least one mechanical connection can be embodied as at least one thread and screw connection and/or at least one positive lock connection.
- It can be provided that a screw head of the at least one thread and screw connection is welded substantially flat, and a remaining substantially flat surface is polished and/or sanded. The screw head of a thread and screw connection can disturb the surfaces of the cooling plate, which as already mentioned contributes to an efficient heat transfer. By welding the screw head flat, e.g. by removing part of the screw head and/or filling a central recess of the screw head, can therefore be beneficial for a substantially flat or (first or second) plane surface of the cooling plate. This can be further improved by sanding and/or polishing the remaining surface.
- Of course, the first and/or second plane surface can also be polished and/or sanded independently of the presence of a thread and screw connection.
- Positive lock connections are connections which fasten two component parts, here the first component part and the second component part, to each other by way of the shape of the objects or geometrical features realising the connection (in contrast to a frictional connection or a force closure).
- The at least one positive lock connection can comprise a hook component part (preferably more than one hook component part) which is separate from the first component part and/or the second component part, wherein the hook component part includes a first hook element and/or a second hook element, and wherein the first hook element is engaged with a first undercut in the first component part and/or the second hook element is engaged with a second undercut in the second component part.
- The terms "hook component part" and "hook elements" here are not be understood narrowly so as to have to have a shape of a commonly known hook. For the purposes of this document "hooks" should merely be understood as geometrical features which cooperate with an undercut or the like in order to achieve a positive lock.
- As such, the hook component part and/or the first hook element and/or the second hook element can for example be embodied as a T-shaped sliding element cooperating with an undercut (in particular if viewed in a cross section). In particularly preferred embodiments the hook component part can be embodied as double T-shaped sliding elements (T-shapes on opposing sides).
- The hook component part and/or the first hook element and/or the second hook element could also incorporate a conical shape instead of a (double) T-shape (in particular if viewed in a cross section).
- The hook component part can preferably be arranged on an inside of the plate body, i.e. not on the periphery of the plate body.
- In a preferred manufacturing method for a cooling plate the method according to the invention further comprises attaching the first component part and the second component part to each other using a positive lock connection, preferably additionally comprising
- using a hook component part (preferably more than one hook component part) which is separate from the first component part and/or the second component part, wherein the hook component part includes a first hook element and/or a second hook element, and
- engaging the first hook element with a first undercut in the first component part and/or engaging the second hook element with a second undercut in the second component part.
- Such embodiments can preferably additionally comprise engaging the first hook element with the undercut in the first component part, bringing the second component part into contact with the first component part, and moving the second component part relative to the first component part laterally along an interface between the first component part and the second component part until the second hook element of the hook component part engages with the second undercut of the second component part, or vice versa.
- It should be mentioned that a force closure can additionally be present when the second component part is moved laterally along the interface with the first component part (or vice versa). Then the first and second component parts are secured on the one hand against unwanted relative lateral movements by the force closure, and potentially another mechanical connection and/or adhesive bond, and are secured on the other hand against unwanted relative axial movements (i.e. parallel to a normal direction on the surface of the cooling plate) by the positive lock connection, and potentially another mechanical connection and/or adhesive bond.
- The at least one adhesive bond can for example be a metallic continuity bond, in particular a welded bond. Other adhesive bonds, for example with an adhesive substance (glue) are of course in principle conceivable.
- The first component part and the second component part can be bonded to each other through the adhesive bond along at least one peripheral side, preferably all peripheral sides, of the first component part and the second component part.
- In particularly preferred embodiments the first component part and the second component part are attached to each other by at least one positive lock connection, preferably with at least one hook component part as described before, and an adhesive bond, in particular a weld, wherein there is preferably no thread and screw connection.
- In such particularly preferred embodiments the at least one positive lock connection can be arranged in a central portion of the cooling plate and the adhesive bond is arranged around the peripheral sides of the cooling plate. In test conducted by the Applicant such particularly preferred embodiments have shown themselves to be particularly advantageous as they are particularly resistant to leaks and corrosion while maintaining a particularly precise geometrical shape.
- The cooling plates can have side lengths between 500mm and 1500mm, preferably between 700mm and 1200mm, and particularly preferably between 800mm and 1100mm.
- Further details and advantages of the invention are apparent from the figures and the accompanying description of the figures. The figures show:
- Fig. 1
- an embodiment of a cooling plate according to the invention,
- Fig. 2a, 2b, 3a, 3b, 4a, 4b, 5, 6
- steps of an exemplary method of manufacturing a cooling plate according to the invention,
- Fig. 7, 8
- an embodiment of a hook component part,
- Fig. 9, 10, 11
- steps of another exemplary method of manufacturing a cooling plate according to the invention,
- Fig. 12, 13, 14
- steps of another exemplary method of manufacturing a cooling plate according to the invention,
- Fig. 15
- schematically an embodiment of a cooling plate according to the invention,
- Fig. 16
- a sectional view of the embodiment of
Fig. 15 , and - Fig. 17
- an embodiment of a cooling device with a cooling plate according to the invention.
-
Fig. 1 shows an exemplary embodiment of acooling plate 1 according to the invention. Aplate body 2 of thecooling plate 1 comprises an internal cooling channel 3 (seeFigures 3a, 3b and 6 ). -
Ports 19 can be used to connect tubing or piping for conveying a cooling medium through the at least onecooling channel 3. - Silicone oil can be used as cooling (or heating) medium.
- In this example the
cooling plate 1 has dimensions of approximately 1074mm by 850mm. -
Fig. 2a, 2b, 3a, 3b, 4a, 4b, 5, and 6 schematically show steps of an embodiment of a manufacturing method for coolingplates 1 according to the invention. - Initially, a first
blank body 17 and a secondblank body 18 are provided (Fig. 2a and 2b , shown in top view). The blank bodies can for example be made of stainless steel. Alternatively the blank bodies could be made of Aluminium or (other) materials which offer high heat transfer, resistance to corrosion and impermeability for a cooling or heating medium. - The first
blank body 17 and/or the secondblank body 18 can be of substantially cuboidal base shape. In preferred embodiments the blank bodies are of substantially plate-like base shape, i.e. a height of the blank bodies may be much smaller than a width and a length of the blank bodies. Preferably the width and length are different from each other. However, embodiments with equal lengths and widths are in principle conceivable. Since the firstblank body 17 and thesecond plate body 18 eventually make up theplate body 2, analogous statements are true for theplate body 2. - In a next step at least one
first recess 5 is formed in the firstblank body 17 and at least onerecess 7 is formed in the second blank body 18 (Fig. 3a and 3b ), such that thefirst recess 5 and thesecond recess 7 correspond to each other geometrically. Herewith, in the terminology of the invention the firstblank body 17 becomes thefirst component part 4 and the secondblank body 18 becomes thesecond component part 6. - In the depicted embodiment the
first recess 5 and thesecond recess 7 are depicted as geometrically substantially equal inFig. 3a and 3b . In other embodiments thefirst recess 5 and thesecond recess 7 can be of different geometrical shape while still able to together delimit the at least onecooling channel 3 in a state where thefirst component part 4 and thesecond component part 6 are attached to each other, as laid out previously. - Before, during or after the
first recess 5 is formed into the firstblank body 17 and/or thesecond recess 7 is formed into the secondblank body 18openings 20, preferably with undercuts or threads, can be formed into the firstblank body 17 and/or the secondblank body 18, which later allow attachment of thefirst component part 4 and thesecond component part 6 to each other. - The forming of the
first recess 5 and/or thesecond recess 7 and/or theopenings 20 can be performed with a machining process, in particular a milling process. - It will be understood that the particular geometry of the at least one
first recess 5, the at least onesecond recess 7, and consequently of the at least onecooling channel 3 depicted inFig. 3a and 3b is a mere example and the geometries can be adapted to achieve the desiredcooling plate 1, in particular the desired layout of the at least onecooling channel 3. -
Fig. 4a and 4b (as well asFig. 5 and 6 ) show thefirst component part 4 and thesecond component part 6 in a sectional view through the planes A indicated inFig. 3a and 3b . - In a next step the
first component part 4 and thesecond component part 6 are brought together with the sides comprising thefirst recess 5 and thesecond recess 7 facing each other at an interface (Fig. 5 ). Thefirst component part 4 and thesecond component part 6 are then attached to each other in this configuration. - Consequently, the
first component part 4 and thesecond component part 6 together become theplate body 2 of thecooling plate 1. Thefirst recess 5 and thesecond recess 7 together delimit the at least onecooling channel 3, as can be seen fromFig. 6 . - The
first component part 4 creates afirst plane surface 15 of theplate body 2 and thesecond component part 6 creates asecond plane surface 16 of theplate body 2. - Attaching the
first component part 4 and thesecond component part 6 to each other can for example be achieved using a positive lock, such as described in connection withFig. 9 to 11 below, and/or a screw and thread connection, such as described in connection withFig. 12 to 14 below, realising a mechanical connection. - Alternatively or additionally, the
first component part 4 and thesecond component part 6 can be attached to each other using an adhesive bond. For example thefirst component part 4 and thesecond component part 6 can be welded to each other along the weldedbond 14 depicted inFig. 6 . Alternatively or additionally, an adhesive or the like can be used in order to facilitate the adhesive bond. - In the embodiment depicted in
Fig. 6 all four peripheral sides of thefirst component part 4 and thesecond component part 6 are attached to each other via the weldedbond 14. -
Fig. 7 and 8 schematically depict ahook component part 9 which can be used to attach thefirst component part 4 and thesecond component part 6 to each other using one or more positive lock connections. -
Fig. 8 shows thehook component part 9 on its own. It comprises twofirst hook elements 11 and twosecond hook elements 12 on opposite sides. It would also be possible to only use onefirst hook element 11 and/or only onesecond hook element 12, or more than two of either. -
Fig. 7 shows thehook component part 9 hooked into the first component part 4 (thefirst component part 4 being depicted in a cutaway view). Several of thesehook component parts 9 can be used for attaching thefirst component part 4 and thesecond component part 6 to each other (or a single one). - As can be seen from
Fig. 3a and 3b theopenings 20 in thefirst component part 4 and thesecond component part 6 have a wider area and a narrower area, where the narrower areas each comprise a first undercut 13 or a second undercut. Thehook component parts 9 can be inserted into the wider area of theopenings 20 and moved laterally into the narrower area such that thefirst hook elements 11 move under the first undercuts 13. In the view depicted inFig. 7 a vertical movement of thehook component part 9 away from thefirst component part 4 is then impeded by the first undercut 13. - Likewise, the
second component part 6 comprises second undercuts (not shown) through which thehook component parts 9 can be hooked into thesecond component part 6. The second undercuts can be embodied substantially equal to the first undercuts 13. - The attachment operation for attaching the
first component part 4 to thesecond component part 6 using thehook component part 9 is shown schematically inFig. 9 to 11 . -
Fig. 9 shows thefirst component part 4 with thehook component parts 9 in the hooked state as shown inFig. 7 . - The
first component part 4 and thesecond component part 6 are then brought into contact with each other with a lateral offset as depicted inFig. 10 . Thehook component parts 9 are thereby inserted into the wider areas of theopenings 20 of the second component part 6 (seeFig. 3b ). - By moving the
second component part 6 laterally relative to thefirst component part 4 thesecond hook elements 12 of thehook component parts 9 move into the narrower areas of theopenings 20 such that thesecond hook elements 12 move over the second undercuts (Fig. 11 ). In the configuration depicted inFig. 11 a vertical movement of thesecond component part 6 away from thefirst component part 4 is then impeded by thefirst hook elements 11 being arranged under the first undercuts 13 and the second hook elements being arranged above the second undercuts. - As mentioned before, an additional adhesive bond (like for example a welded connection) can then be used to inhibit also lateral movement so that the
first component part 4 and thesecond component part 6 are completely fixed to each other. -
Fig. 12 to 14 schematically show an example where thefirst component part 4 and thesecond component part 6 are attached to each other using a screw and thread connection. At first, thefirst component part 4 and thesecond component part 6 are provided (Fig. 12 ), brought into contact with each other and screws are used to fix thefirst component part 4 and thesecond component part 6 to each other (Fig. 13 ). - As can be seen from
Fig. 13 screw heads 8 may protrude from thefirst plane surface 15 or thesecond plane surface 16. - The screw heads 8 can then be welded substantially flat by removing the protruding parts of the screw heads 8 and/or filling up recesses in the screw heads 8 (build-up welding) resulting in the configuration depicted schematically in
Fig. 14 . - After attaching the
first component part 4 and thesecond component part 6 to each other with one of the methods described above (or combinations thereof) thefirst plane surface 15 and/or thesecond plane surface 16 can be polished or sanded in order to achieve a desired surface smoothness or surface structure. -
Fig. 15 shows the embodiment of thecooling plate 1 ofFig. 1 which was manufactured with the methods as described in connection withFig. 2a, 2b, 3a, 3b, 4a, 4b, 5, 6 ,7, 8 ,9, 10, and 11 . However, instead of using six hook component parts 9 a total of 28hook component parts 9 have been used in a grid-like arrangement as indicated inFig. 15 . -
Fig. 16 shows the embodiment ofFig. 15 in a sectional view through a plane parallel to thefirst plane surface 15 and/or thesecond plane surface 16. The layout of the coolingchannel 3 in this embodiment is visible inFig. 16 . - It will be understood that the number and arrangement of the
hook component parts 9 described herein are mere examples. They can be adapted to the particular cooling plate to be manufactured. -
Fig. 17 shows an example of acooling device 10 withcooling plates 1 according to the invention. In this embodiment there are nine coolingplates 1 according to the invention. -
- 1
- Cooling plate
- 2
- Plate body
- 3
- At least one cooling channel
- 4
- First component part
- 5
- First recess
- 6
- Second component part
- 7
- Second recess
- 8
- Screw head
- 9
- Hook component part
- 10
- Cooling device
- 11
- First hook element
- 12
- Second hook element
- 13
- First undercut
- 14
- Welded bond
- 15
- First plane surface
- 16
- Second plane surface
- 17
- First blank body
- 18
- Second blank body
- 19
- Ports
- 20
- Openings
Claims (15)
- Cooling plate comprising a plate body (2) and at least one cooling channel (3) which is disposed inside the plate body (2) and which is at least partly delimited by the plate body (2), wherein the plate body (2)comprises- a first component part (4) with a at least one first recess (5), and- a second component part (6) with at least one second recess (7), which second recess (7) geometrically corresponds to the first recess (5),wherein the first component part (4) and the second component part (6) are attached to each other such that the at least one first recess (5) and the at least one second recess (7) face each other and such that the at least one first recess (5) and the at least one second recess (7) together realise at least part of the at least one cooling channel (3) inside the plate body (2).
- Cooling plate according to claim 1, wherein the first component part (4) and the second component part (6) are attached to each other with at least one mechanical connection and/or at least one adhesive bond.
- Cooling plate according to claim 2, wherein the at least one mechanical connection is at least one thread and screw connection and/or at least one positive lock connection.
- Cooling plate according to claim 2 or 3, wherein a screw head (8) of the at least one thread and screw connection is welded substantially flat, and a remaining substantially flat surface is polished and/or sanded.
- Cooling plate according to claim 3 or 4, wherein the at least one positive lock connection comprises a hook component part (9) which is separate from the first component part (4) and/or the second component part (6), wherein the hook component part (9) includes a first hook element (11) and/or a second hook element (12), and wherein the first hook element (11) is engaged with a first undercut (13) in the first component part (4) and/or the second hook element (12) is engaged with a second undercut in the second component part (6).
- Cooling plate according to at least one of the claims 2 to 5, wherein the at least one adhesive bond is a metallic continuity bond, in particular a welded bond (14).
- Cooling plate according to at least one of the claims 2 to 6, wherein the first component part (4) and the second component part (6) are bonded to each other through the adhesive bond along at least one peripheral side, preferably all peripheral sides, of the first component part (4) and the second component part (6).
- Cooling plate according to one of the preceding claims, wherein the first component part (4) realises a first plane surface (15) of the plate body (2) and/or the second component part (6) realises a second plane surface (16) of the plate body (2).
- Cooling plate according to claim 8, wherein the first component part (4) and the second component part (6) interface along a surface which is substantially parallel to the first plane surface (15) and/or the second plane surface (16).
- Cooling device comprising at least one cooling plate (1) according to at least one of the previous claims.
- Use of a cooling plate (1) according to one of the claims 1 to 9 or of a cooling device (10) according to claim 10 in cooling, in particular freezing, and/or heating, in particular thawing, a liquid occurring in and/or resulting from a pharmaceutical production process, in particular a bio-pharmaceutical production process.
- Method of manufacturing a cooling plate, in particular according to one of the claims 1 to 9, comprising the following steps:- forming at least one first recess (5) into a first blank body (17) yielding a first component part (4),- forming at least one second recess (7) into a second blank body (18) yielding a second component part (6), such that the at least one second recess (7) geometrically corresponds to the at least one first recess (5),- attaching the first component part (4) and the second component part (6) to each other such that the at least one first recess (5) and the at least one second recess (7) face each other and such that the at least one first recess (5) and the at least one second recess (7) together realise at least part of the at least one cooling channel (3) inside a plate body (2) of the cooling plate (1).
- Method according to claim 12, wherein the method further comprises attaching the first component part (4) and the second component part (6) to each other using a positive lock connection.
- Method according to claim 13, wherein the method further comprises- using a hook component part (9) which is separate from the first component part (4) and/or the second component part (6), wherein the hook component part (9) includes a first hook element (11) and/or a second hook element (12), and- engaging the first hook element (11) with a first undercut (13) in the first component part (4) and/or engaging the second hook element (12) with a second undercut in the second component part (6).
- Method according to claim 14, wherein the method further comprises engaging the first hook element (11) with the first undercut (13) in the first component part (4), bringing the second component part (6) into contact with the first component part (4), and moving the second component part (6) relative to the first component part (4) laterally along an interface between the first component part (4) and the second component part (6) until the second hook element (12) of the hook component part (9) engages with the second undercut of the second component part (6), or vice versa.
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EP21202961.5A EP4166884A1 (en) | 2021-10-15 | 2021-10-15 | Cooling plate and method for manufacturing a cooling plate |
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EP21202961.5A EP4166884A1 (en) | 2021-10-15 | 2021-10-15 | Cooling plate and method for manufacturing a cooling plate |
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KR20180015503A (en) * | 2016-08-03 | 2018-02-13 | 한국원자력연구원 | Heat exchanger and nuclear power plant having the same |
WO2018129576A1 (en) | 2017-01-16 | 2018-07-19 | Single Use Support Gmbh | Housing for a flexible container |
TWI640742B (en) * | 2017-11-07 | 2018-11-11 | 奇鋐科技股份有限公司 | Airtight penetration structure for heat dissipation device |
WO2020047571A1 (en) | 2018-09-05 | 2020-03-12 | Single Use Support Gmbh | Cooling plate assembly and method |
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2021
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WO2003001136A1 (en) * | 2001-06-20 | 2003-01-03 | Showa Denko K.K. | Cooling plate and method of producing the same |
JP2004093127A (en) * | 2003-09-16 | 2004-03-25 | Furukawa Electric Co Ltd:The | Heat plate formed by joining metal members |
CN203810844U (en) * | 2014-02-27 | 2014-09-03 | 武汉佰美斯医疗科技有限公司 | Plasma quick-freezing refrigeration plate and plasma quick-freezing device |
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