EP3509636A4 - Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc - Google Patents
Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc Download PDFInfo
- Publication number
- EP3509636A4 EP3509636A4 EP17848290.7A EP17848290A EP3509636A4 EP 3509636 A4 EP3509636 A4 EP 3509636A4 EP 17848290 A EP17848290 A EP 17848290A EP 3509636 A4 EP3509636 A4 EP 3509636A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cns
- injury
- disease
- activity
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000027418 Wounds and injury Diseases 0.000 title 1
- 230000006378 damage Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 208000014674 injury Diseases 0.000 title 1
- 210000003289 regulatory T cell Anatomy 0.000 title 1
- 230000009885 systemic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Manipulator (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP23184844.1A EP4269439A3 (fr) | 2016-09-10 | 2017-09-08 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/261,945 US10519237B2 (en) | 2014-03-12 | 2016-09-10 | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
PCT/IB2016/001433 WO2017042633A2 (fr) | 2015-09-10 | 2016-09-10 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
PCT/IL2017/051011 WO2018047178A1 (fr) | 2016-09-10 | 2017-09-08 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23184844.1A Division EP4269439A3 (fr) | 2016-09-10 | 2017-09-08 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3509636A1 EP3509636A1 (fr) | 2019-07-17 |
EP3509636A4 true EP3509636A4 (fr) | 2020-12-16 |
Family
ID=61561788
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23184844.1A Pending EP4269439A3 (fr) | 2016-09-10 | 2017-09-08 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
EP17848290.7A Withdrawn EP3509636A4 (fr) | 2016-09-10 | 2017-09-08 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23184844.1A Pending EP4269439A3 (fr) | 2016-09-10 | 2017-09-08 | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP4269439A3 (fr) |
JP (2) | JP7074662B2 (fr) |
KR (2) | KR20190050931A (fr) |
CN (2) | CN116492457A (fr) |
AU (2) | AU2017322656B2 (fr) |
CA (1) | CA2997578A1 (fr) |
IL (4) | IL300982B1 (fr) |
MX (1) | MX2018003028A (fr) |
WO (1) | WO2018047178A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
CN117736325A (zh) | 2016-08-09 | 2024-03-22 | 科马布有限公司 | 分离抗体及其应用 |
WO2018083248A1 (fr) | 2016-11-03 | 2018-05-11 | Kymab Limited | Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés |
GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
US11629189B2 (en) | 2017-12-19 | 2023-04-18 | Kymab Limited | Bispecific antibody for ICOS and PD-L1 |
WO2019227090A1 (fr) * | 2018-05-25 | 2019-11-28 | Memorial Sloan Kettering Cancer Center | Diagnostic et traitement d'une neurotoxicité induite par une immunothérapie |
US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
CN111956799A (zh) * | 2020-09-18 | 2020-11-20 | 生物抗素公司 | 抗pd-1抗体和/或pd-l1抗体在制备治疗帕金森病药物中的应用 |
CN112569351B (zh) * | 2020-12-16 | 2021-10-15 | 南通大学 | Cd44抗体在制备治疗帕金森疾病的药物中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017040301A1 (fr) * | 2015-08-28 | 2017-03-09 | Alector Llc | Anticorps anti-siglec-7 et leurs méthodes d'utilisation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050106586A1 (en) * | 2003-06-13 | 2005-05-19 | Mount Sinai Hospital | Detection of neurodegenerative diseases |
CN1838950A (zh) * | 2003-06-23 | 2006-09-27 | 神经化学(国际)有限公司 | 治疗蛋白质聚集疾病的方法 |
ES2437491T3 (es) * | 2003-10-10 | 2014-01-10 | Alchemia Oncology Pty Limited | Modulación de la síntesis y degradación de hialuronano en el tratamiento de enfermedad |
CA2791930A1 (fr) * | 2010-03-11 | 2011-09-15 | Kerry Louise Tyson | Anticorps pd-1 |
CN102492038B (zh) | 2011-12-09 | 2014-05-28 | 中国人民解放军军事医学科学院基础医学研究所 | 抗人Tim-3的中和性单克隆抗体L3D及其用途 |
EP3013355B1 (fr) * | 2013-06-25 | 2019-08-07 | ICM - Institut du Cerveau et da la Moelle Epinière | Il-2 pour utilisation dans le traitement de la maladie d'alzheimer et de troubles associes |
US9394365B1 (en) * | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
KR20230097209A (ko) * | 2014-03-12 | 2023-06-30 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
WO2017042633A2 (fr) * | 2015-09-10 | 2017-03-16 | Yeda Research And Development Co. Ltd | Réduction des quantités ou de l'activité de cellules t régulatrices systémiques pour le traitement de maladie et de lésion du snc |
TWI664190B (zh) * | 2014-06-27 | 2019-07-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
-
2017
- 2017-09-08 EP EP23184844.1A patent/EP4269439A3/fr active Pending
- 2017-09-08 IL IL300982A patent/IL300982B1/en unknown
- 2017-09-08 EP EP17848290.7A patent/EP3509636A4/fr not_active Withdrawn
- 2017-09-08 AU AU2017322656A patent/AU2017322656B2/en active Active
- 2017-09-08 CN CN202310632161.1A patent/CN116492457A/zh active Pending
- 2017-09-08 JP JP2018512191A patent/JP7074662B2/ja active Active
- 2017-09-08 CN CN201780003867.4A patent/CN108348607B/zh active Active
- 2017-09-08 IL IL311841A patent/IL311841A/en unknown
- 2017-09-08 KR KR1020187010034A patent/KR20190050931A/ko not_active IP Right Cessation
- 2017-09-08 WO PCT/IL2017/051011 patent/WO2018047178A1/fr active Application Filing
- 2017-09-08 MX MX2018003028A patent/MX2018003028A/es unknown
- 2017-09-08 CA CA2997578A patent/CA2997578A1/fr active Pending
- 2017-09-08 KR KR1020247014183A patent/KR20240064742A/ko active Search and Examination
-
2018
- 2018-03-05 IL IL257885A patent/IL257885B/en unknown
-
2022
- 2022-03-29 IL IL291784A patent/IL291784B2/en unknown
- 2022-05-12 JP JP2022078512A patent/JP7451596B2/ja active Active
-
2024
- 2024-05-09 AU AU2024203073A patent/AU2024203073A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017040301A1 (fr) * | 2015-08-28 | 2017-03-09 | Alector Llc | Anticorps anti-siglec-7 et leurs méthodes d'utilisation |
Non-Patent Citations (2)
Title |
---|
E. D. HUEY ET AL: "A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia", NEUROLOGY, vol. 66, no. 1, 9 January 2006 (2006-01-09), pages 17 - 22, XP055092755, ISSN: 0028-3878, DOI: 10.1212/01.wnl.0000191304.55196.4d * |
JOSEPHS ET AL: "Argyrophilic grains: A distinct disease or an additive pathology?", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 29, no. 4, 3 March 2008 (2008-03-03), pages 566 - 573, XP022509460, ISSN: 0197-4580, DOI: 10.1016/J.NEUROBIOLAGING.2006.10.032 * |
Also Published As
Publication number | Publication date |
---|---|
KR20240064742A (ko) | 2024-05-13 |
EP4269439A2 (fr) | 2023-11-01 |
EP4269439A3 (fr) | 2024-01-17 |
JP7451596B2 (ja) | 2024-03-18 |
WO2018047178A1 (fr) | 2018-03-15 |
KR20190050931A (ko) | 2019-05-14 |
CN108348607A (zh) | 2018-07-31 |
CN116492457A (zh) | 2023-07-28 |
JP2019530635A (ja) | 2019-10-24 |
AU2017322656A1 (en) | 2018-04-19 |
MX2018003028A (es) | 2018-05-28 |
IL300982B1 (en) | 2024-04-01 |
IL291784A (en) | 2022-06-01 |
AU2017322656B2 (en) | 2024-02-29 |
IL311841A (en) | 2024-05-01 |
JP2022106983A (ja) | 2022-07-20 |
IL291784B1 (en) | 2023-05-01 |
CA2997578A1 (fr) | 2018-03-10 |
AU2024203073A1 (en) | 2024-05-30 |
IL300982A (en) | 2023-04-01 |
IL257885A (en) | 2018-06-28 |
JP7074662B2 (ja) | 2022-05-24 |
EP3509636A1 (fr) | 2019-07-17 |
IL291784B2 (en) | 2023-09-01 |
CN108348607B (zh) | 2023-06-23 |
IL257885B (en) | 2022-05-01 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 27/00 20060101ALI20200714BHEP Ipc: A61P 25/28 20060101ALI20200714BHEP Ipc: A61K 39/395 20060101AFI20200714BHEP Ipc: C07K 16/28 20060101ALI20200714BHEP |
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A4 | Supplementary search report drawn up and despatched |
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