EP3458130A1 - Dispositif de distribution de fluide, procédé de fabrication et procédé d'utilisation d'un dispositif de distribution de fluide destiné à distribuer un fluide - Google Patents

Dispositif de distribution de fluide, procédé de fabrication et procédé d'utilisation d'un dispositif de distribution de fluide destiné à distribuer un fluide

Info

Publication number
EP3458130A1
EP3458130A1 EP17730676.8A EP17730676A EP3458130A1 EP 3458130 A1 EP3458130 A1 EP 3458130A1 EP 17730676 A EP17730676 A EP 17730676A EP 3458130 A1 EP3458130 A1 EP 3458130A1
Authority
EP
European Patent Office
Prior art keywords
fluid
force sensor
spring
release
released
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17730676.8A
Other languages
German (de)
English (en)
Inventor
Fabian Utermoehlen
Andreas Merz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of EP3458130A1 publication Critical patent/EP3458130A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/332—Force measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the spring 200 is tensioned between the release device 115 and the force sensor 205 and is designed to exert a restoring force F 'on the force sensor 205 when the fluid 105 is released.
  • the force sensor 205 is configured to sense the restoring force F 'acting on the force sensor 205 when the fluid 105 is released.
  • Translational movement executes: The larger the set rotation angle, the further the adjusting device is rotated in the form of the adjusting member 215 via an external thread 225 of an internal thread 227 of the housing member 210 away from the projection 222. A distance between the
  • the Dosisknopf 117 is attached to the end of a shaft in the form of the adjusting element 215 having the external thread 225. A counterpart of this
  • Fluid amount can be rotated.
  • the spring 200 is rigidly connected to the projection 222. According to this embodiment, the co-rotation of the spring 200 prevents a change in the number of turns of the spring 200 and there is only one in adjusting the amount of fluid according to this embodiment
  • the determination device 300 is designed to determine and store a released fluid quantity of the fluid using the restoring force F 'sensed by the force sensor 205.
  • Time detector 305 is designed to be at least one
  • the presented fluid dispenser 100 has, for example, with respect to dispensers, which determine the amount of fluid by an optical method by one or more light sources on one side of the fluid storage container and on the opposite side of the
  • a method of operating the presented fluid dispenser 100 is not based on an inductance change of the spring 200 when it is varied in its length, its cross-section or its number of turns.
  • the spring 200 does not have to be contacted on both sides, which would mean a considerable effort for the return of the spring 200 and there is no need for a sliding contact, which wears out mechanically and has a hysteresis.
  • the advantage of the approach presented here is the provision of a
  • Injection device in particular an insulin pen in the form of
  • Fluid dispenser 100 with a spring 200 the length or
  • the fluid delivery device 100 comprises, in addition to the spring 200 and the force sensor 205, a microcontroller for
  • Electronic components in the form of the communication interface 310 for communication with external devices such.
  • a sensor arrangement or dose sensor system for detecting the currently injected amount of insulin with the spring 200 which is either tensioned as described with reference to FIGS. 2 and 3, by its change in length, or, as described with reference to FIG. 4, by a Twist or an increase in the number of turns is stretched and thereby exerts a force on the force sensor 205.
  • the force measurement of the restoring force F ' is carried out when the injection is activated, that is, when the dose button 117 is pressed to release the fluid.
  • the restoring force F ' is then converted into the released amount of fluid, stored and on the integrated display in the form of
  • Display device 315 displayed and / or transferred to an external device.
  • FIG. 4 shows a cross-section of a component of a fluid dispenser 100 according to one embodiment. This may be one of the fluid dispensing devices 100 described with reference to FIGS. 2 to 3, with the difference that the spring 200 according to this embodiment is not rotatably fixed to the bearing surface of the protrusion by the side described with reference to FIG.
  • Force sensors 205 which always require the sweep of a certain angle of rotation to provide a signal.
  • FIG. 5 shows a flow chart of a method 500 for producing a fluid delivery device according to an exemplary embodiment. This may be a method 500 for producing a fluid dispensing device described with reference to FIGS. 2 to 4. In a step 505 of
  • Fluid storage container and a force sensor which is adapted to sense a force acting on the release device when releasing the fluid restoring force provided.
  • a spring is tensioned between the release device and the force sensor, wherein the spring is adapted to apply the restoring force to the force sensor upon release of the fluid.
  • 6 shows a flowchart of a method 600 for operating a fluid delivery device according to an exemplary embodiment. This may be a method 600 for operating one of the fluid dispensing devices described with reference to FIGS. 2 to 4.
  • a step 605 of releasing a fluid is released from a fluid storage container.
  • a 610 of the sensing a restoring force acting in step 605 of the release is sensed on a force sensor, the restoring force being exerted by a spring tensioned between the force sensor and a release device.
  • an exemplary embodiment comprises a "and / or" link between a first feature and a second feature, then this is to be read so that the embodiment according to one embodiment, both the first feature and the second feature and according to another embodiment either only first feature or only the second feature.

Abstract

L'invention concerne un dispositif de distribution de fluide (100) destiné à distribuer un fluide (105). Le dispositif de distribution de fluide (100) présente au moins un dispositif de libération (115) destiné à libérer le fluide (105) contenu dans un contenant de stockage de fluide (122). Le dispositif de distribution de fluide (100) présente également un ressort (200) tendu entre le dispositif de libération (115) et un capteur de force (205) et conçu pour exercer une force de rappel (F') sur le capteur de force (205) lors de la libération du fluide (105). Le dispositif de distribution de fluide (100) présente finalement le capteur de force (205) conçu pour détecter la force de rappel (F') agissant sur le capteur de force (205) lors de la libération du fluide (105).
EP17730676.8A 2016-05-19 2017-05-19 Dispositif de distribution de fluide, procédé de fabrication et procédé d'utilisation d'un dispositif de distribution de fluide destiné à distribuer un fluide Withdrawn EP3458130A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102016208622.7A DE102016208622A1 (de) 2016-05-19 2016-05-19 Fluidabgabevorrichtung, Verfahren zum Herstellen und Verfahren zum Betreiben einer Fluidabgabevorrichtung zum Abgeben eines Fluids
PCT/EP2017/062082 WO2017198809A1 (fr) 2016-05-19 2017-05-19 Dispositif de distribution de fluide, procédé de fabrication et procédé d'utilisation d'un dispositif de distribution de fluide destiné à distribuer un fluide

Publications (1)

Publication Number Publication Date
EP3458130A1 true EP3458130A1 (fr) 2019-03-27

Family

ID=59070596

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17730676.8A Withdrawn EP3458130A1 (fr) 2016-05-19 2017-05-19 Dispositif de distribution de fluide, procédé de fabrication et procédé d'utilisation d'un dispositif de distribution de fluide destiné à distribuer un fluide

Country Status (6)

Country Link
US (1) US20190209783A1 (fr)
EP (1) EP3458130A1 (fr)
JP (1) JP2019514629A (fr)
CN (1) CN109152886A (fr)
DE (1) DE102016208622A1 (fr)
WO (1) WO2017198809A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3675936B1 (fr) * 2017-08-31 2024-05-08 Eli Lilly and Company Détéction de dose avec détection piezoéléctrique pour dispositif d´administration de medicaments
EP3727511B1 (fr) * 2017-12-18 2023-08-16 Sanofi Capteur de rotation pour un dispositif d'injection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309993A (en) * 1980-03-06 1982-01-12 Baxter Travenol Laboratories, Inc. Liquid flow sensing apparatus
DE4220831C1 (de) * 1992-06-25 1994-04-14 Elektronik Vertrieb Gmbh Prüfvorrichtung für Druckinfusionspumpen
US6277099B1 (en) * 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
WO2007075677A2 (fr) * 2005-12-20 2007-07-05 Antares Pharma, Inc. Dispositif d’injection sans aiguille
WO2009039214A2 (fr) * 2007-09-17 2009-03-26 Satish Sundar Pompes à perfusion de haute précision
CN201735018U (zh) * 2010-05-12 2011-02-09 深圳圣诺医疗设备有限公司 注射泵压力检测装置
WO2012140097A2 (fr) * 2011-04-11 2012-10-18 Novo Nordisk A/S Dispositif d'injection incorporant une surveillance de dose
CA2872955A1 (fr) * 2012-05-25 2013-11-28 Smiths Medical Asd, Inc. Detection d'occlusion
CN203043167U (zh) * 2013-01-22 2013-07-10 纪柏 具有剂量记忆功能的胰岛素笔式自动注射器
US20140350517A1 (en) * 2013-05-23 2014-11-27 Allergan, Inc. Injection device with stress protection
WO2015074979A2 (fr) 2013-11-22 2015-05-28 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicament assisté par ressort
DE102015220905A1 (de) * 2015-10-27 2017-04-27 Robert Bosch Gmbh Fluidabgabevorrichtung, Verfahren zum Betreiben einer Fluidabgabevorrichtung und Steuergerät

Also Published As

Publication number Publication date
DE102016208622A1 (de) 2017-11-23
WO2017198809A1 (fr) 2017-11-23
JP2019514629A (ja) 2019-06-06
US20190209783A1 (en) 2019-07-11
CN109152886A (zh) 2019-01-04

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