Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M2005/2006—Having specific accessories
  • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M2005/206—With automatic needle insertion
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M2005/2086—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically having piston damping means, e.g. axially or rotationally acting retarders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
  • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
  • A61M5/321—Means for protection against accidental injuries by used needles
  • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
  • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Definitions

• the present invention relates to the field of liquid product injection devices, in particular pharmaceutical, including automatic injection devices.
• An automatic injection device is generally a medical device for the automatic administration of a liquid drug requiring injection. These devices allow in particular that people, for example with rheumatoid arthritis, multiple sclerosis, diabetes or undergoing anaphylactic shock in case of allergy, themselves inject their drug dose autonomously.
• the device comprises an injection syringe which contains the liquid product to be injected and which is provided with a needle, and a syringe holder. It is usually sufficient to briefly press the device onto the patient's skin to trigger penetration of the needle into the skin, followed by injection of the liquid product, and then retraction of the needle into the device for avoid hurting someone with the needle.
• the injection device is automatic, it comprises an injection spring exerting a pressure on a piston rod via a control member which abuts against the piston rod, thanks to an outline keyed on the proximal end of the piston rod. The piston rod thus moves a piston, which injects the liquid product into the body of the patient.
• a relative rotation of the piston rod and the control member releases the polarizing contour, disabling the stop made by the control member against the piston rod , so that the piston rod is free to move back relative to the control member.
• a protective spring exerts pressure on the syringe body towards the proximal end of the automatic injection device, so that the injection syringe retracts within the automatic injection device so that that the injection needle is no longer accessible.
• the injection rate of the product is greater at the beginning of the injection than at the end because the injection spring exerts a greater force at the beginning of the injection, when it is more compressed.
• An excessive injection rate can be painful for the patient and can in some cases, by shearing molecules of the injected product, degrade this product.
• the injection device should inject the product at a constant rate.
• the invention aims to better control the injection rate at least at certain stages of this injection.
• the subject of the invention is a device for injecting liquid product, intended to receive an injection syringe comprising a syringe body, carrying an injection needle, and a piston mounted to slide axially in the body of the syringe.
• the invention can thus make it possible to slow the flow of product at the beginning and / or at the end of the injection, and thus to improve the quality of the injection.
• the injection axis corresponds to the axis of the injection device defined by the axis of the injection needle.
• the injection axis will be called X.
• the distal direction designates the direction farthest from the fingers of a user, that is to say the closest to the skin of a patient at the time of an injection
• the proximal direction designates the opposite direction.
• the distal direction and the distal direction are the direction and direction that go to the "front" of the injection device.
• the distal end of a patch corresponds to the end on the side of the injection needle, and the proximal end is the opposite end.
• the injection device provided herein is configured to provide automatic product injection, i.e.
• the movement of the piston to inject the product is controlled automatically, usually by a spring.
• the injection device is further configured to provide automatic insertion of the injection needle, i.e. the movement of the needle to penetrate the patient's body is also implemented automatically, by a spring.
• the injection device may further comprise one or more of the following features, taken alone or in combination:
• the slowing cam path comprises at least two slow sections
• the two slow sections have different inclinations so that the axial speed of the piston control member, when the retarding cam travels a first slow section, is less than the axial speed of this piston control member when the slowdown cam goes through a slow second section,
• the slow section of the injection part of the slow cam path coincides with a distal end or a proximal end of the injection portion of this slowing cam path, or with each of the distal and proximal ends,
• the slowing cam path comprises at least two different inclination sections so that the angular displacement of the slowing cam traveling therethrough successively in opposite directions of rotation,
• the slowing cam is carried by the slowing member and the slowing cam path is carried by the positioning control member;
• the device comprises a needle control member intended to cooperate axially, under the effect of an elastic force with a syringe holder, kinematically bonded to the syringe body,
• FIG. 1 is a perspective view of an injection device according to one embodiment of the invention
• FIG. 2 is an exploded perspective view of the injection device of FIG. 1;
• FIGS. 3, 4 and 6 are side perspective views respectively of a piston control member, a retaining ring and an outer casing of the injection device of FIG. 1,
• FIG. 5 is a sectional perspective view from the distal end of the outer casing of FIG. 6;
• FIGS. 7 and 8 are side perspective views respectively of a positioning ring and a piston rod of the injection device of FIG. 1,
• FIG. 10 is a view in axial section of the proximal end of the syringe holder with the elements that it contains when the injection device is mounted,
• FIG. 11 is a perspective side view of a needle control member of the injection device of FIG. 1,
• FIG. 12 is a side view of a positioning control member of the injection device of FIG. 1;
• FIG. 13 is a perspective view, in partial axial section, of several assembled elements of the injection device of FIG. 1;
• FIG. 14 is a perspective view of a positioning control member adapted to a second embodiment according to the invention of the injection device.
• a liquid product injection device 10 allows the automatic administration of a liquid product requiring injection, more particularly a drug. It is intended to receive an injection syringe 12 (visible in particular in Figure 10) containing the liquid product.
• the injection device 10 is configured to provide automatic insertion of the injection needle into the patient's body and automatic injection of the liquid product.
• the injection device 10 comprises a certain number of parts, more precisely in this example a syringe holder 14, two protective springs at the front of the injection device 10, a sleeve of FIG.
• the piston 40 has a distal end oriented towards the injection needle 32 and a proximal end 40P in contact with the injection needle 32.
• piston rod 19 The distal end of the piston rod 19 may in particular be screwed into the piston 40.
• the syringe holder 14 is configured to house the injection syringe 12 so that it is fixedly mounted in the syringe holder 14 throughout the operation of the injection device 10.
• the syringe holder 14 has a distal end disposed on the side of the injection needle 32 and an opposite proximal end 14P.
• the syringe holder 14 has, at its proximal end 14P, an internal clearance 44 delimited by an internal shoulder, making it possible to receive the flange 38 of the syringe body 26 when the injection syringe 12 is inserted. in the syringe holder 14.
• Such internal clearance 44 allows the proximal end 14P to have an inside diameter larger than the rest of the syringe holder 14, and thus to receive, on the one hand, the flange 38, on the other hand
• the positioning ring 50 of the piston rod 19, these two elements having a greater diameter than the syringe body 26.
• the proximal end 14P of the syringe support 14 also has an external shoulder 45, arranged axially in the vicinity. internal clearance 44.
• This outer shoulder 45 forms a blocking relief of the needle control member 21. More specifically, the outer shoulder 45 makes it possible to hook the needle control member 21 on the proximal end 14P of the syringe holder 14 at the time of assembly of a proximal assembly with a distal assembly of the device.
• the control member of the needle 21 is kinematically connected and cooperates axially with the syringe holder 14 until the end of the insertion of the injection needle 32 into the skin of the patient.
• the syringe holder 14 allows the attachment of the end sleeve 16 to the injection device 10.
• the piston rod 19 is kinematically linked to the piston 40 and makes it possible to transmit a pressure on the piston 40 to inject the liquid product.
• the piston rod 19 comprises a distal end 19D and a proximal end 19P
• the piston rod 19 is furthermore configured to be movable between several configurations.
• the first configuration is a thrust configuration in which the piston rod 19 is able to move the piston 40 in the syringe body 26 under the effect of the injection spring 24 between an initial position and an end position. In the end position, the plunger 40 is at the bottom of the syringe body 26, i.e. towards the distal end of the syringe body 26.
• the second configuration is a release configuration in which the piston rod 19 is able to retract in the proximal direction of the injection device 10.
• transition from the thrust configuration to the release configuration is effected by a rotation of the piston control member 22 with respect to the piston rod 19. This rotation of the piston control member 22 and the link with the withdrawal of the injection needle 32 will be explained below.
• the piston rod 19 is generally cylindrical in shape around the injection pin X.
• Two sliding grooves 88 are formed on either side of the piston rod 19.
• Each sliding groove 88 may, for example, be formed by an axial groove.
• These sliding grooves 88 extend axially (parallel to the injection axis X) along the piston rod 19 and define a polarizing contour (visible in particular in Figure 9).
• These sliding grooves 88 are intended to cooperate with a passage opening 92 of the positioning ring 50.
• the piston rod 19 also comprises a distal abutment 90 of axial retention of the positioning ring 50, more precisely two distal stops 90 diametrically opposite.
• each distal stop 90 is formed by a transverse groove formed in a localized filling of the sliding grooves 88.
• the proximal end of the piston rod 19 is of generally cylindrical shape around the injection axis X on its distal portion and comprises four radial projections 87, angularly distributed about the injection axis X, intended to cooperate with the piston control member 22.
• the positioning ring 50 illustrated in Figure 7, is intended to cooperate with the piston rod 19 to allow both a good axial and angular position of the piston rod 19, and prevent the withdrawal of the piston rod 19 from the operating ring 50, or even from the injection device 10.
• the axial positioning makes it possible to ensure a correct position with respect to the piston 40 on the one hand and to the piston control member 22 on the other hand .
• the angular positioning not only prevents the piston rod 19 from rotating on itself during the activation of the piston rod 19 but also provides a predefined angular orientation with respect to the syringe holder 14, allowing abutment axial and then an axial release of the piston rod 19 and the piston control member 22, these configurations being implemented following a rotation of the piston control member 22 by relative to the piston rod 19.
• the positioning ring 50 is intended to be attached to the proximal end 14P of the syringe holder 14.
• the positioning ring 50 comprises angular setting means 98 of the positioning ring 50 on the proximal end 14P of the syringe holder 14.
• the axial positioning means of the piston rod 19 formed on the positioning ring 50 comprise an axial retaining stop 94 of the piston rod 19, here carried by an elastic tab 96 extending axially from a proximal washer 50P to a distal end 50D of the positioning ring 50. More precisely (see FIG.
• the positioning ring 50 comprises two diametrically opposite elastic tabs 96, each carrying an axial retaining stop 94, which is formed in this example by a retaining lug axial axial piston rod 19.
• Each axial retaining stop 94 prevents, by cooperation with the distal stop 90 (visible as in Figure 8) corresponding piston rod 19, that the latter can not be removed entirely (by traction in the proximal direction) of the positioning ring 50 before assembly, and the injection syringe 12 after assembly.
• the means for axial positioning of the piston rod 19 on the positioning ring 50 are moreover arranged so that, in the storage configuration of the injection device 10, a clearance is present between the distal end 19D of the rod of FIG. piston 19 and the proximal end 14P of the piston 40.
• the positioning ring 50 further comprises means for angular positioning of the piston rod 19 on the positioning ring 50, comprising a passage opening 92 (visible in particular in FIGS. 7 and 10) of the piston rod 19 having a complementary polarizer contour of that of the distal end 19D of the piston rod 19.
• the passage opening 92 provides a defined and controlled angular positioning of the piston rod 19 relative to the positioning ring 50 all throughout the operation of the injection device 10.
• the positioning control member 20 which comprises two parts, two half-shells intended to be snapped to one another around the syringe holder 14 by latching means 100 comprising various notches and lugs.
• the positioning control member 20 thus has a generally tubular shape along the injection axis X.
• the distal end of the positioning control member 20 is provided with means for retaining the end sleeve 16. Once assembled, the end sleeve 16 and the positioning control member 20 are fixed relative to one another throughout the operation of the injection device. 10. As shown in FIG. 12, the positioning control member 20 also includes needle control cam 102 and piston control 104 paths for cooperating respectively with needle control cams 46 and piston controller 106 respectively carried by the needle control member 21 and the piston controller 22 (Fig. 13).
• the needle control member 21 and the piston controller 22 are respectively associated with separate cam paths, so that they are each implemented in a precise manner, temporally controlled and adapted to the liquid product injected.
• either or both of the needle control and piston control cam paths are carried respectively by the needle control member and the piston control member, and accordingly, one or both of the needle control cam and piston control cams are carried by the positioning control member.
• the needle control cam 102 and piston control 104 paths each comprise two portions, one distal 102D and 104D and the other proximal 102P and 104P.
• the needle control 46 and piston control cams 106 are engaged in the proximal portions 102P and 104P of the needle control cam paths 102 and 102.
• the needle control 46 and piston control cams 106 are engaged in the distal portions 102D and 104D of the needle control cam paths 102. and the piston control 104.
• the distal portions 102D and 104D of the needle control cam 102 and piston control 104 paths are referred to as the injection portions 102D and 104D of the cam paths 102 and 104.
• the control member of the piston 22 is a slowing member 22.
• the piston control cam path 104 is a slowing cam path 104 and the piston control cam 106 is a deceleration cam 106.
• the injection portion 104D of the deceleration cam path 104 comprises two sections, one proximal, said fast section 104R and the other distal, said slow section 104L.
• the fast section 104R has an inclination identical to that of the proximal portion 104P of the slow cam path 104. It is therefore not possible, simply by observing the positioning control member 20, to distinguish the boundary between the distal portions 104D and proximal 104P of the deceleration cam path 104.
• the slow section 104L has an inclination with respect to the injection axis X greater than that of the fast section 104R.
• FIG. 12 shows that the proximal portion 102P of the needle control cam path 102 has a greater inclination with respect to the injection axis X than the remainder of the needle control cam path 102.
• proximal portion 102P is inclined at about 45 °, which allows advanced p r ogressive of the injection needle 32, and thus limits the patient's pain.
• the advancing speed of the injection needle 32 can be adjusted by changing the inclination of the needle control cam path 102.
• the end of the insertion of the injection needle 32 is done when the needle control member 21 reaches a given angle. At this time, the needle control member 21 disengages from the syringe holder 14, and the injection begins.
• the proximal portion 102P of the needle control cam path 102 rotates the needle control member 21 to this angular position.
• the slope and length of this proximal portion 102P of the needle control cam path 102 thus ensure that the injection needle 32 is inserted at the proper depth and velocity into the skin of the patient before the injection does not begin.
• the needle control member 21 which serves as a slowing member.
• the needle control cam path is a slowing cam path having an injection portion comprising a slow section and a fast section, the slow section having an inclination with respect to the axis. injection X greater than that of the fast section so, for example to obtain a slower injection at the beginning of injection and faster end of injection, or vice versa.
• the temporary coupling means 112 and complementary 114 comprise two complementary parts having a mutual engagement shape, for example two axially extending inverted hooks, the first carried by the proximal end of the control member of needle 21 and the second carried by the distal end of the piston control member 22.
• the needle control member 21 comprises a locking pin 107 (barely visible in Figure 13) protruding of its inner surface and having a funnel-shaped shape, the fine part of the funnel being oriented on the distal side.
• the locking pin 107 is intended to cooperate with the outer shoulder 45 of the proximal end 14P of the syringe holder 14. In fact, this outer shoulder 45 forms a locking relief of the needle control member 21 at the beginning.
• the piston control member 22, visible in particular in Figures 3 and 13 has a generally tubular shape. It is mounted displaceable in the positioning control member 20. It is configured to apply a force on the piston 40 (via the piston rod 19), under the action of the injection spring 24 (visible in Figure 2). This force allows the axial displacement (along the axis of injection X) of the piston 40 in the distal direction of the injection device 10, to inject the liquid product into the skin of the patient.
• the piston control member 22 carries a stop 118 which can be retracted between an active configuration for retaining the injection spring 24 in the compressed state and a retracted configuration for releasing the injection spring 24. More specifically, the organ Piston control 22 comprises two diametrically opposed semi-flexible semi-annular elastic tabs 116, each carrying a retractable stop 118 intended to cooperate with the locking member of the outer casing 25.
• Each of the semi-annular elastic tabs 116 carrying the stops retractable 118 extends axially (along the axis of injection X) towards the proximal end of the injection device 10, each semi-annular elastic tab 116 thus being deformable between a radially spaced rest configuration giving the retractable stop 118 its active configuration and a radially retracted configuration giving the retractable stop 118 its retracted configuration.
• the locking pin 122 comprises two sections of different diameters causing the passage of the retractable stops retracted configuration by a support of the distal end of the injection device 10 on the skin of a patient.
• the piston control member 22 has, at its distal end, a generally cylindrical shape carrying the complementary coupling means 114 and the piston control cam 106, and delimiting a 115, the outer shoulder, forming a seat for the injection spring 24.
• the piston control member 22 also comprises a distal shoulder 117, the distal shoulder 117 is interrupted by notches, extending towards the proximal end of the piston control member 22 so as to form axial slots 119 (visible in Figure 3).
• the piston control cam 106 carried by the piston control member 22 is intended to cooperate with the piston control cam path 104 (visible in FIG. 12) provided in the positioning control member 20 to regulate the displacement of the elements of the injection device 10 under the effect of the injection spring 24 (see Figure 2).
• the rotation of the piston controller 22 is induced by the axial displacement of the piston control cam 106 in the piston control cam path 104.
• the relative angular displacement of the piston control member 22 relative to the piston rod 19 is during the advancement thereof in the syringe body 26, that is during the injection of the liquid product. .
• the relative angular displacement of the piston control member 22 (relative to the piston rod 19) is at a predetermined angle, for example close to 45 °.
• the second part of the angular displacement considered is preferably greater than 1 °, for example close to 2 °.
• This second patient of the movement of the piston control member 22 around the piston rod 19 essentially comprises an angular component.
• the slow section 104L of the distal portion 104D of the piston control cam path 104 takes into account the rotation that remains before alignment of the radial projections 87 with the axial slots 119 while the piston rod 19 has stopped s
• the piston control member 22 no longer abuts against the radial projections 87 of the piston rod 19 and releases a passage for the piston rod 19. that the piston rod 19 can retract in the proximal direction.
• the retaining ring 23 serves to retain the injection spring 24 in the compressed state (see FIGS.
• the injection device 10 presents itself the user in the form of a tube about ten centimeters long. Only the outer casing 25 and the removal member 18, or the end sleeve 16 if the removal member 18 is removed, are visible and accessible to the user.
• the injection needle 32 is protected by a cap not shown in the figures. This cap is removed by means of the withdrawal member 18 illustrated in FIG.
• a first operating step consists of holding the withdrawal member 18 with one hand and the outer casing 25 with the other hand and pulling on the withdrawal member 18 along the injection axis X in a distal direction in order to strip the injection needle 32.
• the injection needle 32 remains inaccessible because, as illustrated in FIG. 5, it is wrapped around the end sleeve 16.
• the end sleeve 16 in the form of the distal end and the injection device 10 is ready for use.
• the injection needle 32 is set back in the end sleeve 16, for example 3 mm (millimeters), to avoid accidental puncture.
• the distal end of the end sleeve 16 is placed against the patient's skin, where the injection of the medical liquid contained in the injection syringe 12 is desired.
• This step is followed by an unlocking step, during which a slight axial pressure is applied in the distal direction on the outer casing 25.
• This support of the distal end of the injection device 10 on the patient's skin triggers an axial displacement of the outer casing 25 towards the end sleeve 16.
• the end sleeve 16 slides slightly inside the outer casing 25 towards its proximal end, generating a sliding, to the inside the outer casing 25 and towards the proximal end of the outer casing 25, the positioning control member 20 and the retaining ring 23.
• This sliding results in the unlocking of the retractable abutment 118 carried by the proximal end. of the piston control member 22.
• the unlocking step is followed by a step of triggering the automatic injection, during which the user continues the axial pressure on the outer casing 25 by pressing on the skin of the patient, in the continuity of the axial pressure started. during the unlocking step.
• This additional pressure generates a compression of the protective springs (not shown) which allows, first of all, a axial approach (along the injection axis X) of the end sleeve 16 and the syringe holder 14.
• the end sleeve 16 slides further inside the outer casing 25 towards its proximal end, generating a additional sliding, inside the outer housing 25 and towards the proximal end of the outer housing 25, the positioning control member 20 and the piston control member 22.
• the retractable stop 118 carried by the piston control member 22 slides towards the proximal end of the outer casing 25, which generates its retraction out of the engagement of the retaining ring 23, by ramping effect between the retractable stop 118 and the proximal surface of the outer casing 25, so that the injection spring 24 is released.
• the release of the injection spring 24 triggers a series of cascading reactions which result in the penetration of the injection needle 32 into the patient's body and the injection of the liquid product contained in the syringe body 26.
• the stroke of the injection needle 32 is 9 mm, so that the injection needle 32 exceeds about 6 mm, corresponding to the depth of injection into the skin of the patient.
• the injection spring 24 thrusts in the distal direction on the piston control member 22 which is, at this stage, coupled with the needle control member 21 due to the entanglement of the means of The displacement of the needle control member 21, being integral with the syringe holder 14 via the outer shoulder 45, generates the displacement in the distal direction of the syringe holder 14.
• the injection syringe 12 is mounted integral with the syringe holder 14, the injection syringe 12 is also pushed towards the distal end of the injection device 10 and the injection needle 32 springs out of the end sleeve 16.
• This axial approximation of the end sleeve 16 and the syringe holder 14 is by sliding of the syringe holder 14 into the end sleeve 16.
• the relative axial advance of the needle control member 21 and the piston control member 22 is controlled by the cooperation of the needle control cams 46 and the piston control cams 106 with the paths. corresponding needle control cams 102 and piston control cams 104 of the positioning control member 20.
• the cooperation between the needle control cams 46, the piston control means 106, the control members Needle 21 and piston control 22 with the corresponding needle control cam 102 and piston control cam paths of the positioning control member 20 independently control the penetration of the injection needle. 32 in the skin of the patient and the injection of the medical liquid contained in the syringe body 26.
• the piston control member 22 completes its rotation about the piston rod 19 and the piston rod 19 is in the release configuration.
• the injection spring 24 is expanded and the two protective springs (not shown) can freely relax: in fact they are no longer subjected to the force exerted by the injection spring 24 and thus generate a protective position in which the syringe holder 14 is axially remote from the end sleeve 16. This axial distance results in the retraction of the injection needle 32 in the end sleeve 16, thus avoiding any risk of injury.
• the syringe holder 14 rises freely in the piston control member 22.
• FIG. 14 a positioning control device 20 adapted to a second embodiment according to the invention of the injection device will be described below.
• elements similar to the elements of the preceding figures are designated by identical references.
• the distal portions 102D and 104D, or injection portions, of the two slowing cam paths 102 and 104 comprise a section, said fast section 102R and 104R, interposed between first and second sections, said sections slow 102L and 104L.
• the rapid sections 102R and 104R and the first and second slow sections 102L and 104L have different inclinations with respect to the axis of injection X so that the axial speed of the needle control members 21 and the piston 22 is lower when their deceleration cams 46 and 106 traverse the slow sections 102L and 104L than when they traverse the 102R and 104R fast sections.
• the slowing cam paths 102 and 104 have sections 102R and 102L or 104R and 104L inclined relative to the injection axis X in opposite directions. These changes in direction of inclination allow to use shorter lengths on some sections, including slow 102L and 104L, without the angle traveled is too important and triggers the decoupling of the body of syringe 26 and the organ 21 or the decoupling of the piston rod 19 and the piston control member 22.
• the two most proximal slow sections 102L and 104L of the deceleration cam paths 102 and 104 coincide with the proximal ends of the distal portions 102D and 104D of these deceleration cam paths 102 and 104. These two sections thus impose a slow velocity in injection start. This slow speed makes it possible to make the flow rate during the injection more constant by preventing the flow rate from being greater at the beginning of the injection because of the greater compression of the injection spring 24.
• the needle control cam path 102 has four distinct sections, three sections 102L and 102R are located on the distal portion 102D of the needle control cam path 102 while the fourth is located on its part. proximal 102P.
• the section carried by the proximal portion 102P has an inclination relative to the injection axis X greater than that of the fast section 102R. This inclination is chosen so that the axial speed of the organs the needle control cam 46 of the needle control member 21 traverses the proximal portion 102P of the needle control cam path 102 when the needle control 21 and piston 22 are lower than when needle control cam 46 traverses the fast section 102R.
• the piston control cam 106 will progressively traverse the slow sections 104L, fast 104R and slow 104L, leading to a successively slow injection speed, then fast and then slow again.
• the different fast and slow sections are not carried by the two slowing cam paths 102 and 104, for example only one of the two needle control cam paths 102 or the piston control 104 of the member positioning control 20 comprises sections whose inclinations are different.
• two slow sections 102L or 104L carried by the same slow-down cam path 102 or 104 may have different inclinations.
• piston control and needle control cam paths meet to form a single cam path.
• the assembly of the injection device 10 comprises four main steps:
• a step of insertion of the injection syringe 12 into the syringe holder 14 from its proximal end 14P a step of insertion of the preassembled positioning ring 50 with the piston rod 19 on the proximal end 14P of the syringe support 14, preferably being positioned relative to one another axially by means of axial positioning 94,
• a first step for this comprises the interlocking of the end sleeve 16 with the withdrawal member 18.
• the step is followed by a step of snap-fitting the syringe holder 14 with the end sleeve 16, by the through the interlocking of radial projections 52 of the syringe holder 14 in proximal windows 80 of the end sleeve 16.
• the protective springs are threaded onto guide rods of the syringe holder 14 and the end sleeve 16 and held in place by snapping the two pieces together.
• proximal subset For this purpose, the positioning control member 20, the needle control member 21, the piston control member 22, the retaining ring 23, the injection spring 24 and the outer casing 25 are assembled. More precisely, the injection spring 24 is first assembled on the proximal end of the piston control member 22. These elements are then placed in one of the two half-shells of the piston member. positioning control 20, by additionally adding the needle control member 21 in the coupling position with the piston control member 22. The second half-shell of the positioning control member 20 is then secured. on the first half-shell, then the outer casing 25 is threaded around these elements, terminating the assembly by snapping the distal end of the outer casing 25 and that of the positioning control member. 20, this snapping nevertheless leaving the possibility of a axial sliding, allowing the positioning control member 20 to move back relative to the outer casing 25.
• This intermediate subassembly comprises the piston rod 19 provided with the positioning ring 50.
• the injection device 10 is assembled by inserting, in the distal subassembly, the injection syringe 12, by inserting the latter into the syringe holder 14 from its proximal end. Once the injection syringe 12 and the distal subassembly have been assembled, the intermediate subassembly is brought back into the proximal end of the syringe body 26, by cooperation of the positioning ring 50 with the syringe holder 14.
• the invention is not limited to the embodiments presented and other embodiments will become apparent to those skilled in the art.
• the positioning ring is assembled while being in the retracted position on the piston rod, then the piston rod is screwed on and the positioning ring is then slid to wedge it on the syringe support and activate. the axial positioning means.
• an injection device 10 configured to provide both automatic insertion of the injection needle 32 into the patient's body and automatic injection of the liquid product once the inserted needle, it is possible to provide a slowing device as described above on an injection device ensuring only an automatic injection of the product and whose injection needle is configured to be manually inserted into the body of the patient.

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• Health & Medical Sciences (AREA)
• Vascular Medicine (AREA)
• Engineering & Computer Science (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)

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• 2015
  • 2015-12-24 FR FR1563313A patent/FR3046079B1/fr not_active Expired - Fee Related
• 2016
  • 2016-12-13 EP EP16826372.1A patent/EP3393553A1/de not_active Withdrawn
  • 2016-12-13 US US16/063,551 patent/US20190001061A1/en not_active Abandoned
  • 2016-12-13 CN CN201680061654.2A patent/CN108348683A/zh active Pending
  • 2016-12-13 JP JP2018522079A patent/JP2018538029A/ja active Pending
  • 2016-12-13 BR BR112018003834A patent/BR112018003834A2/pt not_active Application Discontinuation
  • 2016-12-13 WO PCT/FR2016/053368 patent/WO2017109333A1/fr unknown

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