EP3367785A4 - Zusammensetzungen und verfahren zur chimären embryounterstützten organproduktion - Google Patents

Zusammensetzungen und verfahren zur chimären embryounterstützten organproduktion Download PDF

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Publication number
EP3367785A4
EP3367785A4 EP16860830.5A EP16860830A EP3367785A4 EP 3367785 A4 EP3367785 A4 EP 3367785A4 EP 16860830 A EP16860830 A EP 16860830A EP 3367785 A4 EP3367785 A4 EP 3367785A4
Authority
EP
European Patent Office
Prior art keywords
assisted
compositions
methods
chimeric embryo
organ production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16860830.5A
Other languages
English (en)
French (fr)
Other versions
EP3367785A2 (de
Inventor
Atsushi Asakura
Raj ARAVALLI
Maxim C. CHEERAN
James Dutton
Daniel J. GARRY
Mary G. GARRY
Melanie Graham
Ling Li
Walter Low
Angela Panoskaltsis-Mortari
Timothy O'brien
Clifford Steer
Jakub Tolar
Daniel F. Carlson
Scott C. Fahrenkrug
Naoko KOYANO-NAKAGAWA
Ann PARR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Recombinetics Inc
Original Assignee
University of Minnesota
Recombinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota, Recombinetics Inc filed Critical University of Minnesota
Publication of EP3367785A2 publication Critical patent/EP3367785A2/de
Publication of EP3367785A4 publication Critical patent/EP3367785A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
EP16860830.5A 2015-10-27 2016-10-27 Zusammensetzungen und verfahren zur chimären embryounterstützten organproduktion Withdrawn EP3367785A4 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562247118P 2015-10-27 2015-10-27
US201562246927P 2015-10-27 2015-10-27
US201562247096P 2015-10-27 2015-10-27
US201562247117P 2015-10-27 2015-10-27
US201562246947P 2015-10-27 2015-10-27
US201562247115P 2015-10-27 2015-10-27
US201562246929P 2015-10-27 2015-10-27
US201562247092P 2015-10-27 2015-10-27
US201562246926P 2015-10-27 2015-10-27
US201562247122P 2015-10-27 2015-10-27
PCT/US2016/059206 WO2017075276A2 (en) 2015-10-27 2016-10-27 Compositions and methods for chimeric embryo-assisted organ production

Publications (2)

Publication Number Publication Date
EP3367785A2 EP3367785A2 (de) 2018-09-05
EP3367785A4 true EP3367785A4 (de) 2019-08-14

Family

ID=58631806

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16860830.5A Withdrawn EP3367785A4 (de) 2015-10-27 2016-10-27 Zusammensetzungen und verfahren zur chimären embryounterstützten organproduktion

Country Status (7)

Country Link
EP (1) EP3367785A4 (de)
JP (1) JP2019502400A (de)
KR (1) KR20180100303A (de)
CN (1) CN108697067A (de)
AU (1) AU2016344152A1 (de)
CA (1) CA3003652A1 (de)
WO (1) WO2017075276A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2978457A1 (en) * 2015-03-03 2016-09-09 Regents Of The University Of Minnesota Etv2 and uses thereof
BR112017028608A2 (pt) 2015-06-30 2018-09-04 Univ Minnesota músculo cardíaco humanizado
JP2018522553A (ja) 2015-06-30 2018-08-16 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ヒト化骨格筋
CN109414002A (zh) * 2016-06-14 2019-03-01 里德尔再生医学研究所 使用体细胞核移植(scnt)和囊胚补足的器官再生方法
US20190045761A1 (en) 2017-08-11 2019-02-14 Recombinetics, Inc. Inducible disease models methods of making them and use in tissue complementation
CN109258575B (zh) * 2018-12-10 2021-07-06 广东工业大学 一种蛙类动物胚胎的孵育方法
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
US11859213B2 (en) 2019-05-16 2024-01-02 Regents Of The University Of Minnesota Development of superior chimerism by hiPSC engineering and embryo aggregation
EP3990627A4 (de) * 2019-06-26 2023-07-19 The Regents of The University of California Sirp-alpha-stillgelegte natürliche killerzellen (nk)
US11576889B2 (en) 2019-09-23 2023-02-14 The Board Of Regents Of The University Of Texas System Methods of identifying and treating patients with HIF-2 inhibitor resistance
CN116433652B (zh) * 2023-05-11 2024-02-23 中南大学 用于确定胚胎移植的妊娠结果的方法、处理器及装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100122360A1 (en) * 2007-02-22 2010-05-13 The University Of Tokyo Organ regeneration method utilizing blastocyst complementation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100122360A1 (en) * 2007-02-22 2010-05-13 The University Of Tokyo Organ regeneration method utilizing blastocyst complementation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Japan approves first human-animal embryo experiments", 26 July 2019 (2019-07-26), XP055643771, Retrieved from the Internet <URL:https://www.nature.com/articles/d41586-019-02275-3> [retrieved on 20191119] *
MADHUSUDANA GIRIJA SANAL: "Future of liver transplantation: Non-human primates for patient-specific organs from induced pluripotent stem cells", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 17, no. 32, 2011, CN, pages 3684, XP055602899, ISSN: 1007-9327, DOI: 10.3748/wjg.v17.i32.3684 *
PREETHI SWAMINATHAN: "Human Stem Cell Complementation in PITX3 Null Porcine Blastocysts: Lens Development", December 2014 (2014-12-01), XP055493473, Retrieved from the Internet <URL:https://conservancy.umn.edu/bitstream/handle/11299/185108/Swaminathan_umn_0130M_15713.pdf?sequence=1> [retrieved on 20180718] *
XIANLONG WANG ET AL: "Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs", SCIENTIFIC REPORTS, vol. 5, no. 1, 21 August 2015 (2015-08-21), XP055551206, DOI: 10.1038/srep13348 *
YUYU NIU ET AL: "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", CELL, vol. 156, no. 4, February 2014 (2014-02-01), AMSTERDAM, NL, pages 836 - 843, XP055422516, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.01.027 *

Also Published As

Publication number Publication date
CA3003652A1 (en) 2017-05-04
CN108697067A (zh) 2018-10-23
WO2017075276A2 (en) 2017-05-04
AU2016344152A1 (en) 2018-05-24
JP2019502400A (ja) 2019-01-31
WO2017075276A3 (en) 2017-06-01
KR20180100303A (ko) 2018-09-10
EP3367785A2 (de) 2018-09-05

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