EP3367785A4 - Compositions et procédés de production d'organe assisté par un embryon chimère - Google Patents

Compositions et procédés de production d'organe assisté par un embryon chimère Download PDF

Info

Publication number
EP3367785A4
EP3367785A4 EP16860830.5A EP16860830A EP3367785A4 EP 3367785 A4 EP3367785 A4 EP 3367785A4 EP 16860830 A EP16860830 A EP 16860830A EP 3367785 A4 EP3367785 A4 EP 3367785A4
Authority
EP
European Patent Office
Prior art keywords
assisted
compositions
methods
chimeric embryo
organ production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16860830.5A
Other languages
German (de)
English (en)
Other versions
EP3367785A2 (fr
Inventor
Atsushi Asakura
Raj ARAVALLI
Maxim C. CHEERAN
James Dutton
Daniel J. GARRY
Mary G. GARRY
Melanie Graham
Ling Li
Walter Low
Angela Panoskaltsis-Mortari
Timothy O'brien
Clifford Steer
Jakub Tolar
Daniel F. Carlson
Scott C. Fahrenkrug
Naoko KOYANO-NAKAGAWA
Ann PARR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Recombinetics Inc
Original Assignee
University of Minnesota
Recombinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota, Recombinetics Inc filed Critical University of Minnesota
Publication of EP3367785A2 publication Critical patent/EP3367785A2/fr
Publication of EP3367785A4 publication Critical patent/EP3367785A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
EP16860830.5A 2015-10-27 2016-10-27 Compositions et procédés de production d'organe assisté par un embryon chimère Withdrawn EP3367785A4 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562247117P 2015-10-27 2015-10-27
US201562246947P 2015-10-27 2015-10-27
US201562246926P 2015-10-27 2015-10-27
US201562246929P 2015-10-27 2015-10-27
US201562246927P 2015-10-27 2015-10-27
US201562247115P 2015-10-27 2015-10-27
US201562247096P 2015-10-27 2015-10-27
US201562247122P 2015-10-27 2015-10-27
US201562247118P 2015-10-27 2015-10-27
US201562247092P 2015-10-27 2015-10-27
PCT/US2016/059206 WO2017075276A2 (fr) 2015-10-27 2016-10-27 Compositions et procédés de production d'organe assisté par un embryon chimère

Publications (2)

Publication Number Publication Date
EP3367785A2 EP3367785A2 (fr) 2018-09-05
EP3367785A4 true EP3367785A4 (fr) 2019-08-14

Family

ID=58631806

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16860830.5A Withdrawn EP3367785A4 (fr) 2015-10-27 2016-10-27 Compositions et procédés de production d'organe assisté par un embryon chimère

Country Status (7)

Country Link
EP (1) EP3367785A4 (fr)
JP (1) JP2019502400A (fr)
KR (1) KR20180100303A (fr)
CN (1) CN108697067A (fr)
AU (1) AU2016344152A1 (fr)
CA (1) CA3003652A1 (fr)
WO (1) WO2017075276A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2978457A1 (fr) 2015-03-03 2016-09-09 Regents Of The University Of Minnesota Etv2 et ses utilisations
EP3316899A4 (fr) 2015-06-30 2019-04-03 Regents of the University of Minnesota Muscle cardiaque humanisé
CN108135943A (zh) * 2015-06-30 2018-06-08 明尼苏达大学校董会 人源化的骨骼肌
MX2018015194A (es) * 2016-06-14 2020-01-20 Riddle Inst For Regenerative Medicine Metodo de regeneracion de organos que usa complementacion de celulas de transferencia nuclear de celulas somaticas (scnt) y blastocitos.
US20190045761A1 (en) 2017-08-11 2019-02-14 Recombinetics, Inc. Inducible disease models methods of making them and use in tissue complementation
CN109258575B (zh) * 2018-12-10 2021-07-06 广东工业大学 一种蛙类动物胚胎的孵育方法
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
US11859213B2 (en) 2019-05-16 2024-01-02 Regents Of The University Of Minnesota Development of superior chimerism by hiPSC engineering and embryo aggregation
US20220347215A1 (en) * 2019-06-26 2022-11-03 The Regents Of The University Of California SIRPalpha-SILENCED NATURAL KILLER (NK) CELLS
US11576889B2 (en) 2019-09-23 2023-02-14 The Board Of Regents Of The University Of Texas System Methods of identifying and treating patients with HIF-2 inhibitor resistance
CN116433652B (zh) * 2023-05-11 2024-02-23 中南大学 用于确定胚胎移植的妊娠结果的方法、处理器及装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100122360A1 (en) * 2007-02-22 2010-05-13 The University Of Tokyo Organ regeneration method utilizing blastocyst complementation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100122360A1 (en) * 2007-02-22 2010-05-13 The University Of Tokyo Organ regeneration method utilizing blastocyst complementation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MADHUSUDANA GIRIJA SANAL: "Future of liver transplantation: Non-human primates for patient-specific organs from induced pluripotent stem cells", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 17, no. 32, 2011, CN, pages 3684, XP055602899, ISSN: 1007-9327, DOI: 10.3748/wjg.v17.i32.3684 *
PREETHI SWAMINATHAN: "Human Stem Cell Complementation in PITX3 Null Porcine Blastocysts: Lens Development", December 2014 (2014-12-01), XP055493473, Retrieved from the Internet <URL:https://conservancy.umn.edu/bitstream/handle/11299/185108/Swaminathan_umn_0130M_15713.pdf?sequence=1> [retrieved on 20180718] *
XIANLONG WANG ET AL: "Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs", SCIENTIFIC REPORTS, vol. 5, no. 1, 21 August 2015 (2015-08-21), XP055551206, DOI: 10.1038/srep13348 *
YUYU NIU ET AL: "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", CELL, vol. 156, no. 4, February 2014 (2014-02-01), AMSTERDAM, NL, pages 836 - 843, XP055422516, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.01.027 *

Also Published As

Publication number Publication date
WO2017075276A3 (fr) 2017-06-01
JP2019502400A (ja) 2019-01-31
KR20180100303A (ko) 2018-09-10
CN108697067A (zh) 2018-10-23
WO2017075276A2 (fr) 2017-05-04
CA3003652A1 (fr) 2017-05-04
AU2016344152A1 (en) 2018-05-24
EP3367785A2 (fr) 2018-09-05

Similar Documents

Publication Publication Date Title
IL249982A0 (en) Oligosaccharide compounds and methods of producing them
EP3328363A4 (fr) Compositions et méthodes d&#39;immunomodulation
EP3240555A4 (fr) Compositions multi-compléments
EP3230441A4 (fr) Compositions et méthodes pour la production de scaav
EP3367785A4 (fr) Compositions et procédés de production d&#39;organe assisté par un embryon chimère
EP3316909A4 (fr) Anticorps anti-ntb-a ainsi que compositions et procédés associés
EP3119204A4 (fr) Compositions et procédés pour améliorer la production de tomates
EP3140305A4 (fr) Nouvelles compositions, leurs utilisations et leurs procédés de préparation
EP3224012A4 (fr) Procédés et compositions permettant de fabriquer du béton
EP3040326A4 (fr) Composition d&#39;halogéno-oléfine
EP3145312A4 (fr) Compositions pesticides et procédés associés
EP3186286A4 (fr) Compositions contenant de la cellulose et leurs procédés de production
AU2016291708B2 (en) Plinabulin compositions
EP3223628A4 (fr) Compositions de glycoside
EP3307786A4 (fr) Procédés et compositions de production d&#39;un polypeptide chimérique
EP3229849A4 (fr) Compositions d&#39;additifs pour la désinfection pigmentée et procédés correspondants
EP3442543A4 (fr) Compositions et méthodes pour la neurogenèse
EP3289087A4 (fr) Procédés et compositions pour produire des plants de maïs bachytiques
EP3166892A4 (fr) Compositions anti-calcaire et procédés de fabrication et d&#39;utilisation associés
EP3368077A4 (fr) Compositions et méthodes de transduction tumorale
EP3340808A4 (fr) Procédé de production de compositions édulcorantes et compositions édulcorantes
EP3096757A4 (fr) Compositions d&#39;apilimod et procédés pour les utiliser
EP3253389A4 (fr) Compositions d&#39;apilimod et procédés d&#39;utilisation correspondants
EP3207093A4 (fr) Compositions de résines et leurs procédés de fabrication et d&#39;utilisation
EP3221420A4 (fr) Compositions photochromes-électrochromes

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20180516

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PANOSKALTSIS-MORTARI, ANGELA

Inventor name: PARR, ANN

Inventor name: ASAKURA, ATSUSHI

Inventor name: KOYANO-NAKAGAWA, NAOKO

Inventor name: O'BRIEN, TIMOTHY

Inventor name: GARRY, MARY, G.

Inventor name: DUTTON, JAMES

Inventor name: CHEERAN, MAXIN

Inventor name: CARLSON, DANIEL, F.

Inventor name: LOW, WALTER

Inventor name: FAHRENKRUG, SCOTT, C.

Inventor name: GARRY, DANIEL, J.

Inventor name: ARAVALLI, RAJ

Inventor name: GRAHAM, MELANIE

Inventor name: STEER, CLIFFORD

Inventor name: LI, LING

Inventor name: TOLAR, JAKUP

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHEERAN, MAXIM C.

Inventor name: PARR, ANN

Inventor name: STEER, CLIFFORD

Inventor name: TOLAR, JAKUB

Inventor name: O'BRIEN, TIMOTHY

Inventor name: GARRY, DANIEL, J.

Inventor name: KOYANO-NAKAGAWA, NAOKO

Inventor name: DUTTON, JAMES

Inventor name: CARLSON, DANIEL, F.

Inventor name: PANOSKALTSIS-MORTARI, ANGELA

Inventor name: GARRY, MARY, G.

Inventor name: LOW, WALTER

Inventor name: ASAKURA, ATSUSHI

Inventor name: ARAVALLI, RAJ

Inventor name: LI, LING

Inventor name: FAHRENKRUG, SCOTT, C.

Inventor name: GRAHAM, MELANIE

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/90 20060101ALI20190410BHEP

Ipc: A01K 67/027 20060101AFI20190410BHEP

Ipc: A01N 1/02 20060101ALI20190410BHEP

Ipc: C12N 15/85 20060101ALI20190410BHEP

Ipc: A61D 19/04 20060101ALI20190410BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20190712

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/85 20060101ALI20190708BHEP

Ipc: A01K 67/027 20060101AFI20190708BHEP

Ipc: C12N 15/90 20060101ALI20190708BHEP

Ipc: A61D 19/04 20060101ALI20190708BHEP

Ipc: A01N 1/02 20060101ALI20190708BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1260501

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20200702

RIN1 Information on inventor provided before grant (corrected)

Inventor name: O'BRIEN, TIMOTHY

Inventor name: ARAVALLI, RAJ

Inventor name: FAHRENKRUG, SCOTT, C.

Inventor name: PANOSKALTSIS-MORTARI, ANGELA

Inventor name: PARR, ANN

Inventor name: KOYANO, NAOKO

Inventor name: GARRY, MARY, G.

Inventor name: GARRY, DANIEL, J.

Inventor name: CHEERAN, MAXIM C.

Inventor name: LI, LING

Inventor name: ASAKURA, ATSUSHI

Inventor name: LOW, WALTER

Inventor name: GRAHAM, MELANIE

Inventor name: DUTTON, JAMES

Inventor name: CARLSON, DANIEL, F.

Inventor name: STEER, CLIFFORD

Inventor name: TOLAR, JAKUB

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20210113