EP3344377A1 - Vorrichtung und verfahren zur herstellung einer lösung - Google Patents
Vorrichtung und verfahren zur herstellung einer lösungInfo
- Publication number
- EP3344377A1 EP3344377A1 EP16757563.8A EP16757563A EP3344377A1 EP 3344377 A1 EP3344377 A1 EP 3344377A1 EP 16757563 A EP16757563 A EP 16757563A EP 3344377 A1 EP3344377 A1 EP 3344377A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- medium
- solution
- static mixer
- container
- sterile filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 6
- 230000003068 static effect Effects 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 29
- 238000002156 mixing Methods 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 238000012544 monitoring process Methods 0.000 claims abstract description 3
- 238000004886 process control Methods 0.000 claims description 25
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 2
- 238000007599 discharging Methods 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 239000000243 solution Substances 0.000 description 18
- 238000005516 engineering process Methods 0.000 description 3
- 239000008174 sterile solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/49—Mixing systems, i.e. flow charts or diagrams
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/2201—Control or regulation characterised by the type of control technique used
- B01F35/2202—Controlling the mixing process by feed-back, i.e. a measured parameter of the mixture is measured, compared with the set-value and the feed values are corrected
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/80—After-treatment of the mixture
- B01F23/808—Filtering the mixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/2132—Concentration, pH, pOH, p(ION) or oxygen-demand
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/2133—Electrical conductivity or dielectric constant of the mixture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/2201—Control or regulation characterised by the type of control technique used
- B01F35/2207—Use of data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the computer programs, e.g. for manipulation, handling, production or compounding in mixing plants
Definitions
- the invention relates to a device for producing a solution comprising at least one liquid first medium and at least one further second medium, having a first container for the liquid first medium and a second container for the second medium, wherein the containers each have a controllable by a process control Pump are connected to a supply line of a static mixer, with a downstream of the static mixer in the flow direction connected to the process control sensors, and downstream of the static mixer in the flow direction and also controllable by the process control branch valve.
- the invention further relates to a method for producing a solution of at least one liquid first medium and at least one further second medium using a device according to one of claims 1 to 10.
- Static mixers are usually pipes or channels with fixed internals, which cause the mixing of fluid product streams using the flow energy. Compared with mixers with agitated stirrers, static mixers often have a smaller chamber volume and a very low power requirement. Static mixers are closed systems that require neither maintenance nor inertization. The scale-up risk of static mixers is very low due to the strictly defined geometry and flow control. In today's industrial applications, static mixers are widely used. In addition, the field of application of static mixers is very wide: Mixing of pumpable liquids, dispersing and emulsifying components insoluble in one another, mixing and homogenizing of plastic melts, gas / liquid and liquid / liquid contacting, material transfer, heat transfer and chemical reactions are, for example, applications for the static mixer technology.
- a first container for the liquid first medium and a second container for the second medium are each connected via a controllable by a process control pump with a supply line of a static mixer. Downstream of the static mixer is connected to a sensor for density measurement, with the
- Process control is connected.
- the sensor is downstream in the flow direction controlled by the process control branch valve.
- the disadvantage here is that the security to produce at least two different media a defined composite sterile solution is not sufficiently ensured.
- DE 101 65 007 B4 discloses a filtration device which has filters with RFI D tags for improving the safety of the filtration process.
- Downstream of a sterile filter is that the sterile filter has a RFI D tag, and that the RFID tag has stored process-relevant data which are at least readable by the process control.
- the static mixer downstream of a sterile filter it is ensured that the solution produced is formed as a sterile solution.
- the sterile filter has an RFID tag that has stored process-relevant data that is at least readable by the process control, the user is already enabled in advance to carry out a process control and to avoid faulty structures.
- Process-related data is understood to be data that includes the identity of the filter, the release status, the compatibility with buffer solutions, and
- the set mixing ratio can be controlled and controlled by controlling the pumps.
- the branch valve which can be controlled by the process control, in particular in the case of a mixing ratio exceeding a limit value, the branch valve can be opened and the solution to be discarded can be diverted.
- a third container for a third medium is connected via a controllable by the process control pump with the supply line of the static mixer. This makes it relatively easy and safe to mix in third solution component of the solution to be mixed. For better control of the mixing ratio to be produced, the sensor technology can be extended by a further parameter to be measured.
- the containers likewise each have an RFID tag which can be read at least by the process controller and in which further process-relevant data are stored. This results in a further increased security for a previously performed process control. In particular, it is possible to identify the containers and their contents for compatibility and
- the sensor system is arranged between the static mixer and the sterile filter.
- Branch valve can be arranged between the sensor and the sterile filter. As far as the sensor is downstream of the sterile filter in the flow direction, the controllable branch valve of the sensor is downstream in the flow direction.
- the branch valve is connected to a branch line for branching from solution of insufficient quality.
- the controllable branch valve of the sensor is always downstream in the flow direction to ensure a test before the branch valve.
- the branch line can be connected via a second controllable branch valve with a return line to the first container.
- the static mixer, the sensor system and the sterile filter with RFID tag form a prefabricated one
- a defined composite sterile final fluid is produced with great certainty from at least two different liquids as a solution.
- the method according to the invention has the features and advantages already described above for the device.
- the solution from the branch line is returned via a return line into the first container for the liquid first medium. This makes it possible to bring the already discarded solution still to the desired quality.
- FIG. 1 shows a schematic representation of a device having a first and a second container and a sensor system arranged between a static mixer and a sterile filter
- FIG. 2 shows a schematic representation of a device according to FIG. 1 but with a third container for a third medium
- FIG. 3 shows a schematic view corresponding to FIG. 2, in which the containers each have an RFID tag
- Figure 4 a schematic representation of another device accordingly
- Figure 5 a schematic representation of another device accordingly
- FIG. 4 wherein the sensor system and the branch valve are arranged downstream of the sterile filter in the direction of flow
- FIG. 6 shows a further schematic representation of a device corresponding to that of FIG. 3, however, with a branch valve arranged between the sensor system and the sterile filter and FIG. 6
- Figure 7 a schematic representation of the mixer, the sensor and the
- Sterile filter of Figure 1 as a pre-assembled mixing system.
- a device 1 for producing a solution of at least one liquid first medium and at least one further second medium consists essentially of a first container 2, a second container 3, a first pump 4, a second pump 5, a process controller 6 and a prefabricated mixing system 7th
- the filled with a liquid first medium first container 2 is connected to the in
- Flow direction upstream first pump 4 connected. Accordingly, the second container 3 is connected to the upstream in the flow direction second pump 5.
- the pumps 4, 5 are connected via control lines 8 to the process controller 6.
- the mixing system 7 consists of a static mixer 9, a downstream of the mixer 9 in the flow direction Sensor 10 and a static mixer downstream of the static mixer 9 in the flow direction 11th
- the static mixer 9 has a supply line 12 and a discharge line 13.
- the sensor 10 may have one or more sensors, not shown. With the sensor 10 individual parameters can be determined. For example, by the sensor 10, the conductivity or the pH can be determined. Also, a pressure sensor or a volume sensor can be provided. The sensor 10 is connected via a signal line 14 with the
- the sterile filter 11 has an RFID tag 15 with a memory, not shown, which is read out by the process control 6.
- the memory of the RFI D tag 15 are process-relevant data (identity of the filter, release status, compatibility with
- Buffer solutions and test data stored and can be read out wirelessly from the process controller 6.
- the mixing system 7 has at its connection ends known sterile connectors 16 for the sterile connection.
- the mixing system 7 has a branch valve 17 for discharging rejected solution, which is connected via a further control line 18 to the process controller 6 and is controlled by the process controller 6.
- a third container 19 for a third medium is provided in addition to the first container 2 and the second container 3. Accordingly, the third container 19 upstream of a third pump 20 in the flow direction.
- the embodiment of the device 1 "" of Figure 5 corresponds substantially to the embodiment of Figure 4, but the sensor 10 is the sterile filter 11 in
- the branch valve 17 of the sensor 10 is downstream in the flow direction.
- the static mixer 9, the sensor 10 and the sterile filter 11, which has the RFID tag 15, together with the sterile connectors 6 form connections for connection to the containers 2, 3 or to the containers 2, 3 associated pumps 4, 5, the pre-assembled mixing system. 7
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Software Systems (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Accessories For Mixers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102015114766.1A DE102015114766B4 (de) | 2015-09-03 | 2015-09-03 | Vorrichtung und Verfahren zur Herstellung einer Lösung |
PCT/EP2016/001455 WO2017036589A1 (de) | 2015-09-03 | 2016-08-29 | Vorrichtung und verfahren zur herstellung einer lösung |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3344377A1 true EP3344377A1 (de) | 2018-07-11 |
EP3344377B1 EP3344377B1 (de) | 2019-08-14 |
Family
ID=56802442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP16757563.8A Active EP3344377B1 (de) | 2015-09-03 | 2016-08-29 | Vorrichtung und verfahren zur herstellung einer lösung |
Country Status (5)
Country | Link |
---|---|
US (1) | US11351513B2 (de) |
EP (1) | EP3344377B1 (de) |
CN (1) | CN107847881A (de) |
DE (1) | DE102015114766B4 (de) |
WO (1) | WO2017036589A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102018103634B3 (de) * | 2018-02-19 | 2019-07-04 | Sartorius Stedim Biotech Gmbh | Medienfiltrationsvorrichtung und Verfahren zur Medienfiltration |
CN112835389A (zh) * | 2019-11-22 | 2021-05-25 | 中国人民解放军军事科学院军事医学研究院 | 化学淋浴控制方法及实施该方法的化学淋浴控制装置 |
CN113718375B (zh) * | 2021-10-14 | 2023-06-16 | 山东永成新材料有限公司 | 一种碳纤维生产原液后处理的方法及其装置 |
CN114011322B (zh) * | 2021-11-13 | 2023-09-22 | 江西辙炜新材料科技有限公司 | 一种自洁型水性漆搅拌装置 |
WO2023107667A1 (en) * | 2021-12-10 | 2023-06-15 | 3M Innovative Properties Company | Adhesive dispensing systems and methods |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69432167T2 (de) * | 1993-10-28 | 2003-07-24 | Medrad Inc | System zur Kontrastmittelabgabe |
DE10165007B4 (de) | 2001-11-27 | 2009-08-27 | Sartorius Stedim Biotech Gmbh | Filtrationssystem zur Durchführung und Überwachung eines Filtrationsprozesses von Fluiden |
NL1023520C2 (nl) | 2003-05-23 | 2004-11-24 | Sgt Singapore Holdings Pte Ltd | Snelwisselfiltersysteem alsmede een basis en een snelwisselfilter bestemd voor een dergelijk systeem. |
DE102004054172A1 (de) | 2004-11-10 | 2006-05-18 | Hydac Filtertechnik Gmbh | Filterelement und zugehörige Datenübertragungsvorrichtung |
US20100312174A1 (en) | 2009-06-06 | 2010-12-09 | Hoffman Josef C A | Peritoneal Dialysis System |
CN202199281U (zh) * | 2011-08-16 | 2012-04-25 | 甘肃华羚酪蛋白股份有限公司 | 一种自动配酸装置 |
US9199202B2 (en) * | 2011-09-15 | 2015-12-01 | Sartorius Stedim Biotech Gmbh | Filter element attachment, filter cartridge, and filter system |
JP5828726B2 (ja) | 2011-09-27 | 2015-12-09 | サンスター株式会社 | 液体混合装置 |
EP2682168A1 (de) * | 2012-07-02 | 2014-01-08 | Millipore Corporation | Reinigung biologischer Moleküle |
US10010663B2 (en) | 2013-02-01 | 2018-07-03 | Medtronic, Inc. | Fluid circuit for delivery of renal replacement therapies |
-
2015
- 2015-09-03 DE DE102015114766.1A patent/DE102015114766B4/de active Active
-
2016
- 2016-08-29 EP EP16757563.8A patent/EP3344377B1/de active Active
- 2016-08-29 CN CN201680044668.3A patent/CN107847881A/zh active Pending
- 2016-08-29 WO PCT/EP2016/001455 patent/WO2017036589A1/de active Application Filing
- 2016-08-29 US US15/755,708 patent/US11351513B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
DE102015114766A1 (de) | 2017-03-09 |
EP3344377B1 (de) | 2019-08-14 |
CN107847881A (zh) | 2018-03-27 |
US11351513B2 (en) | 2022-06-07 |
DE102015114766B4 (de) | 2019-04-25 |
US20190022614A1 (en) | 2019-01-24 |
WO2017036589A1 (de) | 2017-03-09 |
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