Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/28—Materials for coating prostheses
  • A61L27/30—Inorganic materials
  • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/02—Inorganic materials
  • A61L27/10—Ceramics or glasses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/28—Materials for coating prostheses
  • A61L27/30—Inorganic materials
  • A61L27/32—Phosphorus-containing materials, e.g. apatite
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
  • A61L27/56—Porous materials, e.g. foams or sponges
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
  • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
  • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
  • A61F2002/30838—Microstructures
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
  • A61F2002/30934—Special articulating surfaces
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2420/00—Materials or methods for coatings medical devices
  • A61L2420/08—Coatings comprising two or more layers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2430/00—Materials or treatment for tissue regeneration
  • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2430/00—Materials or treatment for tissue regeneration
  • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Definitions

• the present invention relates to implants, processes for their preparation and their use.
• Implants for the partial renewal of joint surfaces are known and are implanted when irreparable cartilage damage, e.g. due to osteoarthritis of various joints in the human body and lead to impairments. If, for example, joint surfaces are damaged or destroyed by signs of wear, illness or injury, and if neither conservative non-operative treatment methods nor joint-preserving surgeries promise a successful cure, the implantation of a partial denture usually becomes necessary.
• These partial endoprosthetic implants are understood as a treatment concept in patients for whom the total arthroplasty is too massive a procedure or because of their active lifestyle is out of the question. In this way, to increase the mobility and quality of life in everyday life, work and leisure on the one hand, the pain in the affected joint eliminated or reduced in the long term and on the other the maximum possible mobility of this joint to be restored.
• prosthetic components are offered for hip, knee, shoulder and small joints, based on metallic materials such as titanium or cobalt-chromium, whereby the function of these implants is divided into two parts. They usually have a tribologically stressed part, which serves as an articulation surface, and an osseointegrating part, which grows into the bone tissue and ensures a secure anchorage.
• osteochondral implant which is based on human cartilage and bone tissue and can be minimally invasively implanted in the damaged areas.
• Potentially disadvantageous in such implants are the high wear, the low strengths, aging effects and an insufficient long-term behavior.
• the object of the present invention was to provide implants that do not have the disadvantages of the known solutions.
• the implants according to the invention should in particular have the following properties:
• the implant according to the invention should securely grow together with the bone tissue of the joint after implantation and ensure a sufficiently high anchoring and stability.
• the implant according to the invention should, after implantation, together with the rest of the joint surface, constitute a unit which, from a tribological point of view, is compact and securely and permanently in operative connection with the articulation partner.
• the implant according to the invention should function safely, durably and wear during articulation against a natural cartilage surface
• the implant of the invention should ideally be designed to promote and promote the formation of new, natural cartilage tissue
• the implant according to the invention should not cause any damage to health during its residence in the human body.
• it o o should produce no harmful abrasive particles o in interaction with the articulation partner, in particular with the natural cartilage tissue, this does not cause lasting damage o not be damaged or destroyed by the biomechanical conditions o offer no favorable conditions for infection-causing bacteria.
• the implant according to the invention comprises at least two different functional units (hereinafter also called layers):
• the first unit is an osseointegrating ceramic-based unit that forms a biologically active compound with underlying bone tissue beneath the cartilage.
• the second unit is also a ceramic-based unit, which is connected to the first and tribologically stressed and serve as articulation surface.
• the second unit may also serve as a substrate for an optional third unit.
• the implant may also comprise other units or layers, in particular an optional third unit.
• This optional third entity may be a polymer based entity, preferably based on PVA or hydrogels, which is in firm association with the second entity and which ensures tribological function in articulation with the natural cartilage.
• a hydrogel is a water-containing, but water-insoluble polymer whose molecules are chemically, e.g. By covalent or ionic bonds, or physically, e.g. B. by looping the polymer chains are linked to a three-dimensional network.
• the osseointegrative first unit has a ceramic with porous portions and open-pore, interconnecting structure. It can be prepared in a conventional manner, for example via
• Typical characteristics of such a structure are pore diameters in the order of 100 to 1000 ⁇ , especially between 300 and 700 ⁇ .
• Open porosities are on the order of between 50% and 90%, preferably between 60% and 80%.
• the moduli of elasticity should be on the order of 5 to 50 GPa, ideally in the range of human bone, to provide a beneficial mechanical stimulus for bone formation.
• these structures can be coated with osseoinductive coatings of any kind in a conventional manner, so that the effect of osseointegration is enhanced.
• Phosphating layers in particular covalently bound, monolayer phosphatings
• the second unit has a relatively dense ceramic, which is characterized in particular by its high hardness and strength. It is firmly connected to the first unit.
• the connection to the first unit can be made for example by applying a slurry in the green state and then cosintering, or depending on the method for producing the first unit in one piece.
• the side of the second unit facing the third unit is structured such that it represents an optimum substrate surface for the third unit. This side must then ensure not only a firm positive or non-positive connection, but also a flow apart during the biomechanical loading of the third unit or the lowest possible shear loads. In particular, it should be avoided that internal cracks or other damage to the crosslinked polymer occur.
• a third unit structures are provided in general, which increase the surface and thus provide a good connection between the second and the cartilage or the (optional) third unit, for example via adhesive forces or even medically suitable adhesive.
• defined depressions in the surface which could look like a golf ball structure, or also undercut or drop-shaped depressions in the range of a few ⁇ m up to mm, which provide optimal hold for the polymer materials of the third unit, and for self-stabilization or self-fixing, are suitable axial load or also web-like structures.
• the structure of the second unit, facing away from the second unit and facing a third unit has a very low microroughness in the range of a few ⁇ m, which can be achieved by blending or polishing, or at least those areas of the structure which are at a possible abrasion of the optional third unit exposed.
• the structuring of the ceramic of the second unit can be carried out by means of injection molding processes (ceramic injection molding, low pressure injection molding) or other molding technologies, also by machining in the green state or by laser processing or ultrasonically assisted mechanical processing in the sintered state, or by spark erosion or chemical etching.
• the ceramic material of the first and the second unit is preferably an oxide ceramic from the class of aluminum oxides or zirconium oxides, for example zirconium oxide-reinforced alumina or yttrium-stabilized zirconia, but also all variants thereof or composites with the general designations ZTA (Zirconia toughened alumina) or ATZ (Alumina toughened zirconia).
• zirconium oxide-reinforced alumina or yttrium-stabilized zirconia but also all variants thereof or composites with the general designations ZTA (Zirconia toughened alumina) or ATZ (Alumina toughened zirconia).
• Non-oxide ceramics such as e.g. Materials based on Si3N.
• three-dimensionally linked polymers have proven to be particularly suitable polymers which, in addition to their mechanical properties, in particular with regard to stiffness and shear resilience, also withstand the biomechanical stresses and which resemble those of natural cartilage material. Polymers also have the advantage that they can be loaded with functional groups with which the physical properties can be selectively adjusted.
• hydrogels can be used as carriers of biologically active substances which can produce antibacterial or chondrogenetic action. These biologically active substances favor the in vivo development of endogenous cartilage material.
• synthetic alginates are often used in combination with human stem cells in order to promote the development of the body's own cartilage tissue. This approach could also be integrated into the third unit.
• the internal structure of the polymers in particular of the hydrogels, is designed so that cartilage formation is promoted under mechanical pressure loading and corresponding loading with chondrogenetic substances. These mechanisms also act in natural cartilage, which relies on mechanical stimuli.
• a possible firm connection between the second and optional third unit can take place by positive or non-positive joining processes, but it is also conceivable - especially in the case of undercut structures - to melt the polymers or generally to apply them in the liquid phase.
• the thickness of the polymer or hydrogel layer provided according to the invention depends greatly on the properties of the polymer. Micro or nano coatings can be applied to the second unit or thick layers up to a few mm.
• the implants according to the invention are preferably used for the renewal of joint surfaces in the human body, for example joint surfaces from the shoulder, hip, knee and foot area.
• the implants according to the invention are suitable as joint surfaces for local cartilage defects, as partial joint replacement but also as full endoprostheses. They are particularly suitable for articulations against natural cartilage surfaces, so-called hemiprostheses, for example as a shoulder hemiprosthesis, also referred to as upper arm head prosthesis. This is a partial replacement of the shoulder joint, which preserves the natural shoulder socket (glenoid) and replaces only the humeral head with an endoprosthesis.
• the present invention accordingly relates to:
• Implants according to item 1 characterized in that they contain at least two different functional layers.
• Implants according to item 1 or 2 characterized in that the first layer is ceramic based.
• Implants according to one or more of the preceding points characterized in that the second layer is also ceramic based and bonded to the first layer. Implants according to one or more of the preceding points, characterized in that the first layer has an osseointegrating property.
• Implants according to one or more of the preceding points characterized in that the second layer ensures the tribological function in the articulation with the natural cartilage.
• Implants according to one or more of the preceding points characterized in that the first layer contains a ceramic with porous portions.
• Implants according to one or more of the preceding points characterized in that the first layer contains a ceramic with porous portions and open-pore, interconnecting structure.
• Implants according to one or more of the preceding points characterized in that the first layer pore diameter in the order of 100 to 1000 m, preferably between 300 and 700 ⁇ has.
• Implants according to one or more of the preceding points characterized in that the first layer has open porosities in the order of between 50% and 90%, preferably between 60% and 80%.
• Implants according to one or more of the preceding points characterized in that the elastic moduli of the first layer are of the order of magnitude of between 5 and 50 GPa, preferably in the range of the human bone.
• Implants according to one or more of the preceding points characterized in that the first layer is coated with osseoinduktiven coatings.
• Implants according to one or more of the preceding points characterized in that the first layer is coated with osseoinduktiven coatings, wherein the layer is selected from Biogläsern, hydroxyapatite coatings, phosphating layers, and / or metallic coatings.
• Implants according to one or more of the preceding points characterized in that the first layer is coated with osseoinduktiven coatings, wherein the layer is selected from Biogläsern, preferably from the Bioglas the composition 45S5, from hydroxyapatite coatings, preferably from nanostructured and biomimetic acting hydroxyapatite , from phosphating layers, in particular from covalently bonded, monolayer phosphatings and / or metallic coatings, in particular from metallic coatings, based on tantalum or titanium.
• the layer is selected from Biogläsern, preferably from the Bioglas the composition 45S5, from hydroxyapatite coatings, preferably from nanostructured and biomimetic acting hydroxyapatite , from phosphating layers, in particular from covalently bonded, monolayer phosphatings and / or metallic coatings, in particular from metallic coatings, based on tantalum or titanium.
• Implants according to one or more of the preceding points characterized in that the second layer comprises a relatively dense ceramic.
• Implants according to one or more of the preceding points characterized in that the second layer has high hardness and strength.
• Implants according to one or more of the preceding points characterized in that the second layer has structures which increase the surface.
• Implants according to one or more of the preceding points characterized in that the second layer structures which increase the surface, preferably defined depressions in the surface (golf ball structure), undercut or drop-shaped depressions in the range of a few ⁇ up to mm or web-like structures having.
• Implants according to one or more of the preceding points characterized in that the second layer faces away from the second layer Side has, which has a very low micro-roughness in the range of a few ⁇ .
• Implants according to one or more of the preceding points characterized in that the ceramic material of the first and the second layer contains an oxide ceramic from the class of aluminum oxides or zirconium oxides or a non-oxide ceramic, for example materials based on Si 3 N.
• Embodiment 1 Ceramic-based implant.
• Embodiment 2 Implant according to embodiment 1, characterized in that it contains at least two different functional layers.
• Embodiment 3 Implant according to embodiment 1 or 2, characterized in that the first layer is ceramic-based.
• Embodiment 4 Implant according to one or more of the preceding embodiments, characterized in that the second layer is also ceramic-based and is connected to the first layer.
• Embodiment 5 Implant according to one or more of the preceding embodiments, characterized in that the first layer has an osseointegrating property.
• Embodiment 6 Implant according to one or more of the preceding embodiments, characterized in that the second layer ensures the tribological function in the articulation with the natural cartilage.
• Embodiment 7 Implant according to one or more of the preceding embodiments, characterized in that the first layer contains a ceramic with porous portions.
• Embodiment 8 Implant according to one or more of the preceding embodiments, characterized in that the first layer contains a ceramic with porous portions and open-pore, interconnecting structure.
• Embodiment 9 Implant according to one or more of the preceding embodiments, characterized in that the first layer pore diameter in the order of 100 to 1000 m, preferably between 300 and 700 ⁇ has.
• Embodiment 10 Implant according to one or more of the preceding embodiments, characterized in that the first layer has open porosities in the order of between 50% and 90%, preferably between 60% and 80%.
• Embodiment 1 1 Implant according to one or more of the preceding embodiments, characterized in that the elastic moduli of the first layer are of the order of magnitude of between 5 and 50 GPa, preferably in the region of the human bone.
• Embodiment 12 Implant according to one or more of the preceding embodiments, characterized in that the first layer is coated with osseoinductive coatings.
• Embodiment 13 Implant according to one or more of the preceding embodiments, characterized in that the first layer is coated with osseoinduktiven coatings, wherein the layer is selected from Biogläsern, hydroxyapatite coatings, phosphating layers, and / or metallic coatings.
• Embodiment 14 Implant according to one or more of the preceding embodiments, characterized in that the first layer is coated with osseoinduktiven coatings, wherein the layer is selected from Biogläsern, preferably from the bioglass composition 45S5, from hydroxyapatite coatings, preferably from nanostructured and biomimetic-acting hydroxylapatite layers, of phosphating layers, in particular of covalently bound, monolayer phosphatings and / or metallic coatings, in particular of metallic coatings, based on tantalum or titanium.
• the layer is selected from Biogläsern, preferably from the bioglass composition 45S5, from hydroxyapatite coatings, preferably from nanostructured and biomimetic-acting hydroxylapatite layers, of phosphating layers, in particular of covalently bound, monolayer phosphatings and / or metallic coatings, in particular of metallic coatings, based on tantalum or titanium.
• Embodiment 15 Implant according to one or more of the preceding embodiments, characterized in that the second layer comprises a relatively dense ceramic.
• Embodiment 16 Implant according to one or more of the preceding embodiments, characterized in that the second layer has high hardness and strength.
• Embodiment 17 Implant according to one or more of the preceding embodiments, characterized in that the second layer has structures which increase the surface.
• Embodiment 18 Implant according to one or more of the preceding embodiments, characterized in that the second layer structures which increase the surface, preferably defined depressions in the surface, (golf ball structure), undercut or drop-shaped depressions in the range of a few ⁇ up to mm or web-like structures.
• Embodiment 19 Implant according to one or more of the preceding embodiments, characterized in that the second layer has a side facing away from the second layer, which has a very low microroughness in the range of a few ⁇ .
• Embodiment 20 Implant according to one or more of the preceding embodiments, characterized in that the ceramic material of the first and the second layer contains an oxide ceramic from the class of aluminum oxides or zirconium oxides or a non-oxide ceramic, for example materials based on Si 3 N.
• the present invention relates to the use of the implant according to one or more of the preceding embodiments for the renewal of joint surfaces in the human body, for example, joint surfaces of the shoulder, hip, knee and foot area.
• Embodiment 22 Use of the implant according to one or more of the preceding embodiments as joint surfaces for local cartilage defects, as a partial joint replacement but also as a complete endoprosthesis.
• Embodiment 23 Use of the implant according to one or more of the preceding embodiments in articulations against natural cartilage surfaces.

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• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Transplantation (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Public Health (AREA)
• Medicinal Chemistry (AREA)
• Epidemiology (AREA)
• Dermatology (AREA)
• Inorganic Chemistry (AREA)
• Dispersion Chemistry (AREA)
• Engineering & Computer Science (AREA)
• Ceramic Engineering (AREA)
• Orthopedic Medicine & Surgery (AREA)
• Cardiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Vascular Medicine (AREA)
• Prostheses (AREA)
• Materials For Medical Uses (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

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Family Applications (1)

Country Status (8)

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• 2016
  • 2016-08-31 RU RU2018111492A patent/RU2018111492A/ru not_active Application Discontinuation
  • 2016-08-31 EP EP16759747.5A patent/EP3344300A1/de not_active Withdrawn
  • 2016-08-31 BR BR112018003226-3A patent/BR112018003226A2/pt not_active Application Discontinuation
  • 2016-08-31 US US15/755,949 patent/US20180250445A1/en not_active Abandoned
  • 2016-08-31 DE DE102016216414.7A patent/DE102016216414A1/de not_active Withdrawn
  • 2016-08-31 KR KR1020187009329A patent/KR20180050353A/ko unknown
  • 2016-08-31 CN CN201680049934.1A patent/CN107921176A/zh active Pending
  • 2016-08-31 WO PCT/EP2016/070482 patent/WO2017037098A1/de active Application Filing

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