EP3223876A1 - Procédé et appareil pour recueillir et mélanger du fluide hématique - Google Patents

Procédé et appareil pour recueillir et mélanger du fluide hématique

Info

Publication number
EP3223876A1
EP3223876A1 EP15823006.0A EP15823006A EP3223876A1 EP 3223876 A1 EP3223876 A1 EP 3223876A1 EP 15823006 A EP15823006 A EP 15823006A EP 3223876 A1 EP3223876 A1 EP 3223876A1
Authority
EP
European Patent Office
Prior art keywords
flow rate
weight
verification
volume
hematic fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15823006.0A
Other languages
German (de)
English (en)
Inventor
Norberto SALA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delcon Srl
Original Assignee
Delcon Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delcon Srl filed Critical Delcon Srl
Publication of EP3223876A1 publication Critical patent/EP3223876A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/024—Means for controlling the quantity of transfused blood, e.g. by weighing the container and automatic stopping of the transfusion after reaching a determined amount
    • A61M1/0245—Means for controlling the quantity of transfused blood, e.g. by weighing the container and automatic stopping of the transfusion after reaching a determined amount combined with blood container shaking means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/025—Means for agitating or shaking blood containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/025—Means for agitating or shaking blood containers
    • A61M1/0254—Means for agitating or shaking blood containers with a support plate moving only in one plane, e.g. horizontal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards

Definitions

  • Forms of embodiment described here concern a method and an apparatus to collect and mix a determinate volume or weight of a hematic fluid, usable in the medical field in particular to collect and mix blood, blood components and/or blood products, more in particular in the course of hematic fluid transfer/collection procedures.
  • the blood, or blood components can be taken from and/or respectively supplied to the patient using sacs, normally containing an anti-coagulant, connected to plastic tubes inside which the blood or its components flow.
  • the donor in the case of blood donations, the donor is made to lie on a bed, a hemostatic tourniquet is applied on one arm and a needle is inserted in a vein.
  • the needle is connected to a tube, in turn connected to a sac to collect the blood.
  • the blood flows spontaneously until it fills the collection sac in which an anti- coagulant solution or liquid are already contained, and also other substances or solutions useful for preserving the blood in the best possible way.
  • some test tubes are filled so that the tests laid down by law can be carried out.
  • the volume of blood removed is generally established by law, to guarantee an adequate preparation of the haemocomponents (concentrates of red corpuscles, platelets, plasma units), and also to prevent complications for the donor.
  • the volume of blood taken in a donation is established by the Ministerial Decree of 3/3/2005, and is 450 ml ⁇ 10%.
  • the Applicant has devised, tested and embodied the present invention to overcome the shortcomings of the state of the art and to obtain these and other purposes and advantages.
  • a method is provided to collect and mix a determinate volume or weight of a hematic fluid.
  • the method comprises:
  • the method provides to stop the mixing, if the verification of the last fraction of volume or weight is negative, the method continues repetitively from the first reading and display of the current volume or weight;
  • the method provides to stop the hematic fluid transfer, if the verification of the target volume or weight collected is negative, it continues repetitively from the second reading and display of the current volume or weight;
  • a movement unit configured to move the support plate to determine the mixing of the hematic fluid in the collection sac
  • the movement unit comprises a drive member, provided with a drive shaft, configured to determine the movement of the support plate and mounted on a motor support frame associated to the sensor unit.
  • - fig. 1 1 is an enlarged detail of fig. 10;
  • a tube as used in the forms of embodiment described here can be a tube for use in the field of medical blood transfusions, a flexible tube, a test tube, a pipe, a standard tube for disposable blood sacs or for plasmapheresis.
  • a tube as used in the forms of embodiment described here can be a plastic tube, in particular PVC.
  • a tube as used in the forms of embodiment described here can be an elongated hollow tubular body with a determinate diameter that can vary, by way of non-restrictive example, from about 2.7 mm to about 6 mm, and which has a lateral wall defining internally a passage channel.
  • the lateral wall can have a determinate thickness that can vary, for example, from about 0.4 mm to about 1.0 mm.
  • a collection sac is positioned on a support plate or tray, and a transfer tube is connected to the collection sac and clamped by means of a clamp;
  • a second signal of flow rate error 124 is provided and the method continues repetitively from the second reading and display of the current volume or weight 120, if the second verification of flow rate control 122 is negative, i.e. an error is not verified in the flow rate of hematic fluid, a verification is provided of the target volume or weight collected 126;
  • the method provides to stop the hematic fluid transfer 128, if the verification of the target volume or weight collected 126 is negative, the procedure continues repetitively from the second reading and display of the current volume or weight 120;
  • the method provides the end of hematic fluid transfer procedure 130.
  • the transfer of the hematic fluid starts by positioning the sac on the support plate and inserting the tube into the clamp to control the flow, and hence the flow rate.
  • the transfer proper starts at the moment the verifying start-up command 106 is positive and the hematic fluid transfer 108 starts.
  • the verification of the last fraction of volume or weight 1 16 controls that a determinate volume remains, before the conclusion of the transfer procedure, for example 25 ml or in any case a value from 5% to 10%, in particular from 5% to 7.5% of the value of the final target volume to be achieved in the collection sac.
  • the final target volume is in relation to the volumetric capacity of the sac as discussed above.
  • the mixing movement stops and the volume is read continuously until, for example, 450 ml is reached. Then the clamp closes and the acoustic and visual signal that the hematic fluid transfer has finished is activated.
  • the start of the hematic fluid transfer 108 can be a routine in the method according to the present description which can be implemented to manage the operations that allow to start the hematic fluid transfer.
  • fig. 2 is used to describe forms of embodiment of the start of the hematic fluid transfer 108 usable in combination with the forms of embodiment described using fig. 1.
  • the start of the hematic fluid transfer 108 can include:
  • the method provides to acquire the initial tare of the support plate and subsequently a drive member is started that makes the support plate move, for example rotate or oscillate, for mixing, and the clamp is opened to enable the flow of hematic fluid to the sac.
  • the method begins to acquire the volume or weight of the hematic fluid contained in the sac with the first reading and display of the current volume or weight and to calculate the mean flow rate of the hematic fluid.
  • the volume or weight is advantageously read when the support plate is in the horizontal position or as near as possible to horizontal ("HOME"). Therefore, reaching the "HOME” position is propaedeutic to reading the volume or weight and to making the reading as precise as possible.
  • the first reading and display of the current volume or weight 1 10 and the second reading and display of the current volume or weight 120 can be routines in the method according to the present description which can be implemented to manage the operations that allow to detect and monitor the development over time of the quantity of hematic fluid transferred to the collection sac.
  • fig. 3 is used to describe forms of embodiment of the first reading and display of the current volume or weight 1 10 usable in combination with the forms of embodiment described using figs. 1 and 2.
  • the description can be valid and applied also to the forms of embodiment of the second reading and display of the current volume or weight 120.
  • the first reading and display of the current volume or weight 1 10 can include:
  • the method continues with the reading of the current volume or weight 146, while if the verification of the support plate in reading position 144 is negative, it passes to the end of volume or weight reading 148.
  • the method 100 provides measures and strategies, implemented through the first verification of flow rate control 1 12 and the second verification of flow rate control 122 so that the flow rate of hematic fluid through the tube is comprised between a minimum limit and a maximum limit, otherwise the first signal of flow rate error 1 14 and the second signal of flow rate error 124 are activated.
  • the error signals can be for example visual and/or acoustic.
  • the first verification of flow rate control 1 12 and the second verification of flow rate control 122 can be routines of the method according to the present description which can be implemented to manage the operations that allow to control the flow of hematic fluid through the tube.
  • fig. 4 is used to describe forms of embodiment of the first verification of flow rate control 1 12 usable in combination with the forms of embodiment described using figs. 1, 2 and 3. The description can be valid and applied also to the forms of embodiment of the second verification of flow rate control 122.
  • the first verification of flow rate control 1 12 can include:
  • the calculation of current flow rate 152 is carried out by putting into relation the volume or weight of the hematic fluid contained in the collection sac, deriving from the first reading and display of the current volume or weight 1 10 or from the second reading and display of the current volume or weight 120, with the time that has passed since the start of the hematic fluid transfer 108.
  • the method provides that when a predefined fraction of volume is still to be transferred, as controlled by the verification of the last fraction of volume or weight 1 16 to complete the final weight or volume expected in the sac for the transfer of hematic fluid, the support plate is stopped in the HOME position (stop of mixing 1 18) to have a more precise reading of the quantity of hematic fluid collected.
  • the clamp is closed (stoppage of the hematic fluid transfer 128) and the end of hematic fluid transfer procedure 130 is signaled, for example by activating a visual and/or acoustic end- of-donation signal.
  • the stoppage of the transfer of hematic fluid 128 can be a routine in the method according to the present description which can be implemented to manage the operations that allow to finish the transfer of hematic fluid.
  • fig. 5 is used to describe forms of embodiment of the stoppage of the transfer of hematic fluid 128 usable in combination with the forms of embodiment described using figs. 1, 2, 3 and 4.
  • the stoppage of the transfer of hematic fluid 128 can include:
  • Forms of embodiment described here using figs. 6, 7 and 8 also concern an apparatus 200 to collect and mix a determinate volume or weight of hematic fluid according to the present description, usable in a possible procedure to transfer/collect a desired quantity, weight or volume of hematic fluid in a collection sac.
  • the apparatus 200 includes:
  • a support plate or tray 202 to receive and support a collection sac fluidically connected to a transfer tube of the hematic fluid
  • a sensor unit 204 configured to detect the weight force acting on the support plate 202, i.e. to detect the volume or weight of the hematic fluid contained in the sac that is gradually transferred into the sac;
  • a movement unit 206 configured to move the support plate or tray 202 to determine the mixing of the hematic fluid in the collection sac; - a clamp or closing pincer 208 to selectively stop the flow of hematic fluid in the transfer tube;
  • control card 210 configured to receive a signal of volume or weight from the sensor unit 204 and to calculate the current flow rate of hematic fluid
  • a user interface 212 provided with an insertion device 214 and a display device 216, both associated to the control card 210.
  • the sensor unit 204 can be configured to detect at least the weight force of the hematic fluid that gradually fills the collection sac, acting on the support plate or tray 202.
  • the sensor unit 204 can be set to detect a datum or signal of the weight force, or corresponding volume, by a suitable conversion, which can be programmable thanks to the control card 210.
  • the conversion of weight and volume can be carried out by the sensor unit 204 or the control card 210.
  • the weight force on the support plate or tray 202 can be detected by one or more load cells, one or more pressure sensors or one or more other sensors, which use an extensometer, a piezoelectric element, a piezo resistive element, a Hall effect element or suchlike.
  • a pressure is the force exerted per unitary surface, so that depending on whether one or more sensors are provided, such as pressure sensors or force sensors or load cells, it could be necessary to consider a conversion.
  • the sensor unit can also include at least a pressure sensor and at least a force sensor, for example a load cell.
  • the sensor unit 204 can include at least one sensor, like a pressure sensor or force sensor, for example a load cell, in which the at least one sensor is a sensor that is independent of an actuator that applies the pressure or force; for example the sensor does not activate, move or influence the collection sac, the support plate or tray 202 or any other part or portion of the apparatus 200.
  • the sensors included in the sensor unit 204 as used in the forms of embodiment described here can be at least a sensor element selected from the group comprising:
  • a force sensor or transducer like a load cell, for example a load cell with extensometer, a hydraulic or hydrostatic load cell, a piezoelectric load cell, a vibrating wire load cell and a capacitive load cell,
  • a pressure sensor or transducer for example the electronic type generally used to collect a force to measure deformation or divergence caused by the force applied above an area, such as a sensor with a piezo resistive sensor, a capacitive sensor, an electromagnetic sensor, a piezoelectric sensor, an optical sensor or a potentiometric sensor.
  • the sensor unit 204 can include one or more sensors that can be a load cell.
  • the load cell can be equipped with a mechanical shut-down system for strain 245 and a mechanical shut-down system for compression 246 (see fig. 11 for example), so as to prevent damage caused by exceeding the maximum load defined by the construction specifications.
  • the movement unit 206 can be configured to determine an alternate motion of the support plate 202.
  • the movement unit 206 can be an oscillation or rotational unit, able to determine an alternate rotational or oscillatory motion of the support plate 202.
  • the movement unit 206 can be set to impart a desired movement speed, for example frequency of oscillation, which can be programmable thanks to the control card 210.
  • the movement unit 206 can be set to perform different movement cycles or phases, in particular oscillation, with different durations and speeds, for example with different frequencies of oscillation, in programmable mode thanks to the control card 210.
  • the movement unit 206 can be configured to determine a "two-dimensional" (2D) oscillation of the support plate 202, i.e. an oscillation around a single axis of oscillation so that the travel made by the support plate 202 always lies on a single oscillation plane to which the oscillation axis is transverse, in particular orthogonal (see arrow F in fig. 7 and figs. 10, 1 1 for example).
  • the oscillation axis can pass through the support plate 202, or be outside it.
  • the movement unit 206 can be configured to determine a "three-dimensional" (3D) oscillation of the support plate 202, i.e. an oscillation around two oscillation axes transverse to each other, in particular orthogonal, so that the travel made by the support plate 202 develops in space, and not on a single plane (see arrows F and G in fig. 8 and figs. 12, 13 for example).
  • the oscillation axes can pass through the support plate 202, or be outside it.
  • the movement unit 206 can include a drive member 207, provided with a drive shaft 213, and configured to determine the desired movement of the support plate 202.
  • the drive member 207 can be in particular a motor provided with an intrinsically rotational movement actuator or configured to convert a linear movement into a circular movement. The conversion can commonly be made using types of conversion mechanisms, for example screw actuators, ball screw actuators and roll screw actuators.
  • a drive member 207 as used in association with the forms of embodiment described here can be a drive member chosen from a group comprising: an electric motor, a step electric motor, a magnetic motor, a linear axle with a motor, a linear motor, such as a mechanical linear motor, a piezoelectric linear motor, an electromagnetic linear motor, an electromechanical motor, an electromagnet, a ratiometer, in particular a direct current ratiometer.
  • motors can be provided that use electromagnetism and magnetic fields for interaction between a first part formed by electric coils and a second part formed by other electric coils, or by permanent or energized magnets or a conductor.
  • the drive member can be configured as a linear motor, for example an induction linear motor, synchronous linear motor, brushless synchronous linear motor, homopolar linear motor, voice coil linear motor, tubular linear motor or also, as we said, a piezoelectric linear motor or an electromagnet.
  • the drive member 207 can be a direct current ratiometer with a nominal voltage of 12 V.
  • the clamp or closing pincer 208 can be an intelligent clamp which can be configured for example to automatically stop the flow when the set volume is reached.
  • the clamp 208 can be configured to define at least three conditions, which are:
  • the clamp 208 can be provided with a sensor to recognize the presence of the tube in the clamp.
  • the sensor to recognize the presence of the tube in the clamp can be used to implement an automatic closing of the clamp 208, i. e. to automatically assume the closed condition when the tube is inserted in the clamp 208.
  • the automatic closing can take place even if the expected volume or weight of the hematic fluid has been reached.
  • the clamp 208 can be implemented with a safety function, which can intervene in the event of electric power failure.
  • the clamp 208 can be driven for safety reasons to activate or maintain the closed condition of the tube, in which the flow of hematic fluid is prevented, also in the event of an electric power failure of the apparatus 200, for example thanks to the provision of a buffer feed system of the apparatus 200 (see hereafter).
  • control card 210 can include a central processing unit (CPU) 203, an electronic memory 205, possibly an electronic database and auxiliary circuits (or I/O) (not shown).
  • CPU central processing unit
  • the CPU 203 can be any type of controller, microcontroller, processor or microprocessor used in the field of control, automation and management of the work or computer cycle.
  • the electronic memory 205 can be connected to the CPU 203 and can be one or more of those commercially available, such as a random access memory (RAM), read only memory (ROM), an erasable programmable memory (EPROM), an electrically erasable programmable ROM memory (EEPROM), floppy disk, hard disk, optical disks, CD-ROM, optical-magnetic disks, optical or magnetic cards, mass memory, solid-state memory cards or microcards or any other form of digital storage, local or remote.
  • the software instructions and the data can be for example encoded and memorized in the electronic memory 205 to command the CPU 203.
  • the auxiliary circuits can also be connected to the CPU 203 to help the processor conventionally.
  • the auxiliary circuits can include for example at least one of: cache circuits, feed circuits, clock circuits, input/output circuits, subsystems and suchlike.
  • the control card 210 can include a timer 215, which can be dedicated or implemented using a clock circuit present in the auxiliary circuits of the control card 210 for this purpose.
  • the CPU 203 can calculate the current volume or weight of the hematic fluid in the collection sac during transfer, and perform the verifications of the volume or weight and controls of the flow rate as described above, which are necessary for the purposes of the method according to the present description.
  • a program (or computer instructions) readable by the control card 210 can determine which tasks are performable according to the method 100 according to the present description.
  • the program is a software readable by the control card 210.
  • the control card 210 can include a code to generate and memorize information and data introduced or generated during the method 100 according to the present description.
  • the electronic memory 205 can contain memorized and programmable information concerning, for example, the volume or weight of hematic fluid to be transferred/collected in the collection sacs, and also programmable information or data on the speed of movement, in particular for example oscillation, which the movement unit 206 can impart to the support plate or tray 202 to determine the desired mixing of the hematic fluid in the collection sac.
  • the insertion device 214 of the user interface 212 can be an alphanumerical keyboard, a pushbutton, pressure keys or buttons, touch keys or buttons, physical or virtual keys/buttons.
  • a start key 214a can be provided, activated to start the transfer of hematic fluid according to the method 100 described here.
  • the verification of the start-up command 106 cited above can be implemented to verify, for example electrically, electronically, mechanically or electromechanically, that the start key 214a has been activated, for example pressed.
  • the display device 216 of the user interface 212 can be a digital display, a liquid crystal display, a touchscreen.
  • the touchscreen can integrate the functions both of the insertion device 214 and the display device 216.
  • the apparatus 200 can include an external casing 201 (see figs. 7 and 8 for example) which contains and encloses inside it the sensor unit 204, the movement unit 206 and the control card 210.
  • the user interface 212 and the clamp 208 are disposed outside the casing 201.
  • the support plate 202 is positioned in an external seating 209 defined by the casing 201.
  • the external seating 209 can have an aperture to connect the support plate 202 to the movement unit 206 contained in the casing 201.
  • Fig. 9 is used to describe possible forms of embodiment, which can be combined with all the forms of embodiment described here, of an apparatus 200 which includes the support plate 202, the sensor unit 204, the movement unit 206 and the control card 210.
  • the sensor unit 204 can be a load cell.
  • the movement unit 206 can be a two-dimensional oscillation unit.
  • the apparatus 200 described using fig. 9 includes the control card 210 with CPU 203 and memory 205, the display device 216, for example a Liquid Crystal Display, the insertion device 214, for example a keyboard.
  • the apparatus 200 described using fig. 9 can also include a visual signaler 218, for example a state light, such as a LED (Light Emitting Diode), an acoustic signaler 220, for example an acoustic alarm or buzzer, which can be used to signal errors, or to signal the start or completion of one or more steps and/or operations of the method 100 described here.
  • a visual signaler 218 for example a state light, such as a LED (Light Emitting Diode)
  • an acoustic signaler 220 for example an acoustic alarm or buzzer, which can be used to signal errors, or to signal the start or completion of one or more steps and/or operations of the method 100 described here.
  • the movement unit 206 can be provided with the drive member 207, mounted on a motor support frame 211.
  • the motor support frame 211 can be for example C-shaped, formed in particular by two opposite lateral walls or blades 211a, between which the drive member 207 extends, and a transverse connection wall 21 lb.
  • the motor support frame 21 1 supports the drive member 207, cooperating with the respective drive shaft 213.
  • the drive member 207 is in particular disposed so that the drive axis of rotation defined by the drive shaft 213 is always parallel to the lying plane of the support plate 202.
  • the drive axis of rotation defined by the drive shaft 213 of the drive member 207 is disposed horizontal.
  • the support plate 202 is disposed to be in a horizontal position, when inactive, and can be subjected to alternate oscillations (positive and negative) with respect to the horizontal, as will be described in more detail hereafter, but without the drive axis of rotation defined by the drive shaft 213 of the drive member 207 intersecting the lying plane of the support plate 202.
  • the oscillation bar 236 has a sliding slit 238, with an elongated longitudinal shape, inside which the eccentric pin 234 is slidingly housed.
  • the eccentric pin 234 draws the oscillation bar 236 into oscillation, causing the alternate oscillation motion of the support plate 202 around a single axis defined by the oscillation pin 237.
  • the oscillation movement of the support plate 202 is therefore two-dimensional as defined above, following for example the arrow in fig. 7 and also represented in figs. 10 and 1 1.
  • a sensor member 244 can be provided, able to detect the HOME position of the support plate 202, in particular being configured to detect the presence of a reference element in movement associated with the rotary disc 232 in the immediate vicinity of the sensitive side of the sensor member 244, without there being an actual physical contact.
  • Figs. 12 and 13 are used to describe forms of embodiment of a movement unit 206 usable for example in combination with the forms of embodiment described using figs. 8 and 9, to determine a "three-dimensional" oscillation of the support plate 202.
  • the movement unit 206 can be provided with the drive member 207, mounted on the motor support frame 21 1.
  • the motor support frame 21 1 can be C-shaped, formed in particular by two opposite lateral walls or blades 211a and a transverse connection wall 211b, to which the drive member 207 is attached suspended (fig. 12).

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un procédé (100) pour recueillir et mélanger un volume ou un poids déterminé d'un fluide hématique en vue d'une utilisation dans le domaine des transfusions de sang médicales, le procédé consistant à : initier une procédure de transfert (102), positionner une poche et un tube (104), commencer le transfert de fluide hématique (108) en commençant à mélanger le fluide hématique contenu dans la poche, lire et afficher une première valeur du volume ou du poids (110) de fluide hématique actuellement contenu dans la poche, effectuer une première vérification de la régulation du débit (112), vérifier la dernière fraction de volume ou de poids (116) pour compléter le volume ou le poids final dans la poche destinée au transfert de fluide hématique, arrêter de mélanger (118), lire et afficher une deuxième valeur du volume ou du poids (120) de fluide hématique actuellement contenu dans la poche, effectuer une seconde vérification de la régulation du débit (122), vérifier le volume ou le poids cible collecté (126), arrêter le transfert de fluide hématique (128) et terminer la procédure de transfert de fluide hématique (130).
EP15823006.0A 2014-11-25 2015-11-24 Procédé et appareil pour recueillir et mélanger du fluide hématique Withdrawn EP3223876A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20142030 2014-11-25
PCT/IB2015/059086 WO2016084001A1 (fr) 2014-11-25 2015-11-24 Procédé et appareil pour recueillir et mélanger du fluide hématique

Publications (1)

Publication Number Publication Date
EP3223876A1 true EP3223876A1 (fr) 2017-10-04

Family

ID=52232331

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15823006.0A Withdrawn EP3223876A1 (fr) 2014-11-25 2015-11-24 Procédé et appareil pour recueillir et mélanger du fluide hématique

Country Status (3)

Country Link
EP (1) EP3223876A1 (fr)
CN (1) CN107206134B (fr)
WO (1) WO2016084001A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016212608B3 (de) * 2016-07-11 2018-01-11 B Medical Systems S.à r.l. Agitatoreinheit zur Verwendung mit einem Blutproduktlagersystem und Blutproduktlagersystem
WO2019152800A2 (fr) * 2018-02-02 2019-08-08 Helmer, Inc. Agitateur de plaquettes avec commandes d'entrée d'utilisateur discontinues
GB2581985B (en) * 2019-03-06 2021-09-15 Pplus Skin Care Ltd Apparatus for storing platelet-rich plasma
FR3094643B1 (fr) 2019-04-08 2022-09-02 Maco Pharma Sa Dispositif de pincement pour appareil médical
FR3094629B1 (fr) 2019-04-08 2021-03-19 Maco Pharma Sa Appareil pour la collecte de sang
WO2022132770A1 (fr) * 2020-12-15 2022-06-23 Global Life Sciences Solutions Usa Llc Système, procédé et appareil pour mélanger un fluide dans un système de biotraitement
CN112755864A (zh) * 2021-01-25 2021-05-07 肖尚峰 一种dna鉴定样品收集器及其使用方法
CN113101433B (zh) * 2021-05-20 2022-09-27 山东大学齐鲁医院(青岛) 一种血液科骨髓采集用处理方法
EP4169542A1 (fr) * 2021-10-25 2023-04-26 Fresenius Kabi Deutschland GmbH Dispositif oscillant pour déplacer une poche de sang et procédé de fonctionnement d'un dispositif oscillant
CN114258908A (zh) * 2021-11-18 2022-04-01 庄乐乐 一种脐带血干细胞医用储藏箱
CN114178059B (zh) * 2021-11-23 2023-10-03 辽阳友信制药机械科技有限公司 一种血液科病人血液分层离心设备

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3924700A (en) * 1974-11-29 1975-12-09 Lifeline Instr Inc Blood withdrawing device
FR2544220A2 (fr) * 1983-04-14 1984-10-19 Baudry Etienne Agitateur de sang
FR2574540B1 (fr) * 1984-12-10 1988-05-13 Henri Brunet Balance-agitateur pour prelevements sanguins
FR2603190A1 (fr) * 1986-08-29 1988-03-04 Rgl Transfusion Sanguine Centr Procede et appareil de controle quantitatif de prelevement, ainsi que procede et installation de prelevement pour traitement du sang d'un donneur
WO1995004557A1 (fr) * 1993-08-05 1995-02-16 Max-Medical Pty. Ltd. Appareil de surveillance pour don du sang
DE19623368A1 (de) * 1996-06-12 1997-12-18 Transmed Medtech Gmbh Blutentnahmegerät
ITMI20122026A1 (it) * 2012-11-28 2014-05-29 Delcon S R L Macchina e metodo per la miscelazione del contenuto di sacche ematiche
CN103758014B (zh) * 2014-01-15 2016-02-17 柳工无锡路面机械有限公司 具有定向振动和圆周振荡的多功能振动轮及其调节方法

Also Published As

Publication number Publication date
WO2016084001A1 (fr) 2016-06-02
CN107206134B (zh) 2020-11-17
CN107206134A (zh) 2017-09-26

Similar Documents

Publication Publication Date Title
WO2016084001A1 (fr) Procédé et appareil pour recueillir et mélanger du fluide hématique
JP5242626B2 (ja) 腹膜透析療法用ポータブル装置
CN105073158B (zh) 腹膜透析系统以及相关的装置和方法
CN103282062B (zh) 用于检测或验证连接至体外血液处理控制台的血液回路的方法和系统
AU2021206852B2 (en) Devices, methods, and systems for priming, separating, and collecting blood components
US20080177222A1 (en) Weight controlled dialysis system with accelerometer
EP2883557B1 (fr) Système de traitement sanguin extracorporel pour traitement individualisé
US20190046710A1 (en) Systems and methods for monitoring a fluid procedure using hydrostatic pressure
CA2456357C (fr) Methode et dispositif d'echantillonnage d'un liquide biologique auquel une solution est ajoutee afin de maintenir une concentration donnee
CN109152871A (zh) 体液排放装置
CN104334205B (zh) 血液处理装置、控制方法及计算机程序
JP2019523676A (ja) 体排液装置
EP3248627B1 (fr) Systèmes et procédés d'amorçage d'un circuit de fluide
CN110234372A (zh) 用于自动除气和填充导管的装置和方法
EP3198273B1 (fr) Appareil pour surveiller la coagulation du sang
WO2020091588A1 (fr) Système de dialyse péritonéale
US20230117917A1 (en) Hemodialysis system reservoir level sensor
CA2102941A1 (fr) Dispositif de prelevement et d'agitation de sang

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20170621

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20191024

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20220601