EP3129459A1 - Mischvorrichtung zum mischen eines inhalts eines behälters - Google Patents
Mischvorrichtung zum mischen eines inhalts eines behältersInfo
- Publication number
- EP3129459A1 EP3129459A1 EP15724173.8A EP15724173A EP3129459A1 EP 3129459 A1 EP3129459 A1 EP 3129459A1 EP 15724173 A EP15724173 A EP 15724173A EP 3129459 A1 EP3129459 A1 EP 3129459A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- removal
- container carrier
- carrier
- pivot axis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/46—Means for fastening
Definitions
- the present invention relates to a mixing device for mixing a content of a container.
- containers are used for mixing or circulating materials.
- culture media for microorganisms or controlled biotechnological processes such as cell cultivation of the mixing or the circulation of the container contents is of particular importance. Due to the different initial concentrations of the substances and the metabolic activity of the microorganisms during cultivation, there are local concentration changes of various chemical components in the media mixture or of nutrients, oxygen and the resulting metabolites during cultivation.
- concentration changes of various chemical components in the media mixture or of nutrients, oxygen and the resulting metabolites during cultivation.
- the use of flexible disposable bioreactors made of films is steadily increasing in importance, particularly in view of the ever increasing demands on the sterility of the processes in bioprocessing technology over rigid containers made of glass or stainless steel.
- the film bags offer further advantages such as cost-effective production, eirifache and space-saving storage, the greatest possible protection against contamination and the elimination of costly cleaning after use.
- stirrerless mixers are considered advantageous because no passages through the container wall for driving stirrers are necessary .
- such mixers are known as rockers, platform shakers, tumble mixers, orbital shakers, vibratory shakers, horizontal shakers, orbital shakers, etc.
- Flexible containers may vary in size depending on the application, with larger containers having volumes of several liters.
- the most previously filled containers are usually placed on plate-shaped or trough-shaped movable supports, e.g. be fixed by clamps or hooks or other releasable fasteners on the carriers.
- the carriers are driven and produce the mixing movement of the contents of the container.
- the carrier carries out, for example, a rocking movement about a horizontal position.
- the carriers In order to remove the contents of the bag, the carriers can be moved with the bags fixed thereon in a nearly vertical position. It may also be possible to fill the containers in the vertical position.
- WO 2012/115581 A1 discloses a bioreactor with a mixing device in which a container carrier performs a rocking motion about a horizontal rocking axis for mixing a content of a container.
- a set-up axis is arranged, about which the container carrier can be pivoted to set up the Benzoiter carrier, wherein the erecting axis is parallel to the rocking axis.
- the container carrier can be inclined in the erected state about a second tilting axis, which is perpendicular to the erection axis, to a corner of the container.
- a mixing apparatus for mixing a contents of a container, comprising: a container carrier for carrying the container; and a moving device connected to move the container carrier with the container carrier to mix the contents of the container in a mixing position; the container carrier having a positioning device adapted to position the container in a predetermined position on the container carrier such that a withdrawal side of the container is disposed substantially along a predetermined line of the container carrier the container carrier is pivotally mounted about a take-off pivot axis relative to the movement device for displacing the container positionable thereto into a removal position, wherein the removal pivot axis is at a pivot axis angle greater than 0 ° to 45 ° to the predetermined line of the container Carrier is arranged that the positionable container can be moved from the mixing position by means of a pivoting movement of the container carrier about the removal pivot axis in the removal position, in which the removal side located on the lower side of the container and inclined to a removal region of the container t is.
- the container may, in particular, be a bioreactor container, which may be made of a film material. Such a container may be designed as a bag with edges welded at least on two opposite sides.
- the container may have a predetermined bearing surface on which the container can be stored stably on a horizontal surface.
- the support surface may in particular be one of its largest surfaces or side surfaces.
- the support surface and / or the surface opposite the support surface passages and connections for Have supply and / or discharge lines and / or sensors. If the supply and / or discharge lines are located on the support surface, the container carrier also has corresponding passages for the connected lines.
- the container can be arranged with its bearing surface on the container carrier.
- the container may have in plan view a substantially quadrangular shape with four side edges.
- the container may be formed symmetrically in plan view, which is advantageous for a uniform movement of the contents of the container during mixing.
- At least the container has a removal side.
- the removal side may be a substantially straight side edge of the container, wherein a side edge of the container interior is meant.
- the withdrawal side refers to the side of the container which is provided for collection and removal of the contents of the container and in particular of the products which have formed in the container.
- the removal area of the container can be arranged in one of the two corners of the removal side. At the removal area, an outlet can be arranged, from which the contents of the container can be omitted.
- the container positioned on the container carrier is displaced together with the container carrier for removal into the removal position.
- a filling of the container is also possible in this position via the supply lines arranged on the container.
- the contents of the container may be a liquid or a suspension.
- the container may further contain a gas or gases.
- the contents of the container is mixed or circulated by means of the mixing device, whereby a good oxygen mixing can be ensured, in particular during cell cultivation.
- the container carrier is designed such that the container can be arranged thereon.
- the container carrier can be designed such that the container with its container carrier facing the largest surface or its support surface substantially completely rests against the upper surface of the container carrier.
- the upper surface of the container carrier may be referred to as a receiving surface.
- the container carrier can, for example, plate or be formed tub-shaped and executed in the plan view is substantially square.
- the trough-shaped container carriers serve to absorb the escaping fluid from the containers in the event of leaks in the containers.
- the size of the container carrier is not limited and may be selected depending on the container size.
- the shape and size of the container carrier in the plan view corresponds substantially to the shape and size of the container in plan view.
- the moving device is configured to move the container carrier to perform the mixing movement.
- the movement device preferably via a movable coupling element, connected to the container carrier.
- the container carrier When moving the container to mix the contents of the container, the container carrier is in a mixing position and the container positioned thereon is in a mixing position. In the mixed position, the container carrier, or the receiving surface thereof, is oriented substantially horizontally. More specifically, in the mixing layer for mixing, the container carrier performs motion around or in the horizontal plane.
- the mixing device may be referred to as rocker, platform shaker, tumble mixer, orbital shaker, vibratory shaker, horizontal shaker, orbital shaker, etc.
- the container carrier performs a tilting or rocking motion about a substantially horizontal axis, with the container carrier initially in a range of about 0-15 °, preferably in a range of about 0-10 °, is inclined to the horizontal plane, and then in the opposite direction in a range of about 0-15 °, preferably in a range of about 0-10 °, is inclined to the horizontal plane.
- This movement of the container carrier is transferred to the container, so that a wave movement of the contents of the container can be generated.
- the mixing movement of the container support does not necessarily include inclining to the horizontal plane, and instead the container support may be reciprocated linearly or circularly in the horizontal plane and / or horizontally reciprocated in the vertical direction be shaken.
- the mixed layer is thus changeable by the movement of the container carrier, but is substantially in the horizontal plane or differs only slightly from this.
- the container carrier has a predetermined or predeterminable rest position, which is assumed when the container carrier performs no mixing movement in the mixing position.
- the container disposed on the container carrier In the rest position, the container disposed on the container carrier is in a rest position. In the rest position or rest position, the container carrier or the container is preferably oriented approximately horizontally. The same applies to the mixing position of the arranged on the container carrier container.
- the container carrier has a positioning device, which can be provided in each case on one or more sides of the container carrier.
- the positioning device may, for example, terminals, clamping rails and / or Befestigüng hook.
- the positioning device can enable releasable positioning or fixing of the container to the container carrier.
- the positioning device is designed to position the container in a predetermined or predeterminable position on the container carrier / so that the removal side of the container is arranged substantially along a predetermined imaginary line of the container carrier.
- the predetermined line is an imaginary line and does not need to be visible on the container carrier.
- This imaginary line of the container carrier extends the removal side of the container, in particular the substantially straight side edge of the container interior, when the container is positioned by means of the positioning device on the container carrier.
- the predetermined line may coincide with, or parallel to, a side edge of the container carrier at the sampling side.
- the removal pivot axis can in this case also be defined with respect to the side edge of the container carrier, namely that the removal pivot axis at an angle of about 0 ° to 45 °, preferably about 1 ° to about 15 °, more preferably about 3 ° to about 0 °, is arranged to the side edge of the container carrier.
- the predetermined line can also coincide with the extension direction of a clamping rail of the positioning device or run parallel to it.
- the removal pivot axis can also be defined in this case with respect to the extension direction of the clamping rail, namely that the removal pivot axis at an angle of about 0 ° to 45 °, preferably about 1 ° to about 15 °, more preferably about 3 ° is arranged to about 10 °, to the extension direction of the clamping rail.
- the container carrier may have a stop for the removal side of the container, in which case the predetermined line may coincide with the direction of extension of the stop or may be parallel thereto.
- the removal pivot axis can also be defined in this case with respect to the extension direction of the stop, namely that the removal pivot axis at an angle of about 0 ° to 45 °, preferably about 1 ° to about 15 °, more preferably about 3 ° is arranged to about 10 °, to the extension direction of the stop.
- the predetermined line may be parallel to an axis of symmetry of the container carrier.
- the removal pivot axis can also be defined in this case with respect to the symmetry axis of the container carrier, namely that the removal pivot axis at an angle of about 0 ° to 45 °, preferably about 1 ° to about 15 °, more preferably about 3 ° to about 10 °, is arranged to the axis of symmetry of the container carrier.
- the container carrier is pivotally mounted on the moving device and can be pivoted relative to the moving device. This pivoting movement is independent of the mixing movement of the container-carrier and is basically not carried out during the mixing movement.
- the pivotability of the container carrier relative to the movement device allows a displacement of the container carrier from the mixing layer into a removal position. Accordingly, the pivotability of the container carrier relative to the movement device allows a displacement of the arranged on the container carrier container from a mixing position to a removal position.
- the Relocating from the mixed layer or mixing position into the removal position or removal position can also be referred to as "erection".
- the container In the removal position, the container is oriented such that the removal side is located in the vertical direction on the lower side of the container and is inclined to a removal region of the container.
- the removal region may be located in the region of one of the lower corners of the container, wherein the removal region may be located directly in the corner itself or on the upper surface or support surface of the container near the corner.
- the support surface of the container In the removal position, the support surface of the container is inclined at a steep angle to the horizontal plane, and the withdrawal side of the container forms the lower side or edge of the container.
- the withdrawal side of the container is inclined to the horizontal plane, but at a shallower angle.
- the inclination angle of the extraction side to the horizontal plane approximately corresponds to the pivot axis angle between the extraction pivot axis and the predetermined line of the container support.
- the support surface is inclined less than 90 ° to the horizontal plane, the inclination angle of the extraction side to the horizontal plane is less than the pivot axis angle between the extraction pivot axis and the predetermined line of the container support.
- the support surface of the container may be inclined in the removal position at an angle of 30 ° to 90 °, preferably 35 ° to 55 ° to the horizontal plane.
- the receiving surface of the container carrier is inclined at a steep angle to the horizontal plane, and the predetermined line of the container carrier is also inclined to the horizontal plane, but at a shallower angle.
- the inclination angle of the predetermined line to the horizontal plane approximately corresponds to the pivot axis angle between the take-off pivot axis and the predetermined line.
- the inclination angle of the predetermined line to the horizontal plane is less than the pivot axis angle between the unloading pivot axis and the predetermined line.
- the receiving surface of the container carrier can in the Picking position at an angle of 30 ° to 90 °, preferably 35 ° to 55 °, be inclined to the horizontal plane.
- the take-off pivot axis is located at a pivot axis angle greater than 0 ° to 45 ° to the predetermined line of the container carrier, here meaning the smallest angle (ie, an angle between 0 ° and 90 °) between the take-off pivot axis and the predetermined line is.
- the pivot axis angle is to be determined as the angle between the direction vectors of the extraction pivot axis and the predetermined line.
- the pivot axis angle is the largest detectable angle between 0 ° and 90 ° between the projected lines of the extraction pivot axis and the predetermined line on all possible planes in space.
- the pivot axis angle corresponds to the angle between the lines projected on the horizontal plane of the extraction pivot axis and the predetermined line when the container support (or the receiving surface thereof) is aligned to the horizontal plane or if the container carrier in the Mischiage or restiage is.
- the take-off pivot axis is inclined within the horizontal plane from the predetermined line about the pivot axis angle, and has no inclination to the horizontal plane.
- the container carrier and / or the movement device may have a pivot bearing, which connects the container carrier with the movement device, wherein the pivot axis of the pivot bearing of the removal pivot axis corresponds.
- the oblique arrangement of the withdrawal Pivoting axis to the predetermined line of the container-carrier that the container carrier and the positionable container can be moved by means of a single pivoting movement in an advantageous removal position or removal position.
- the removal position of the container carrier is placed opposite the horizontal plane.
- the container is preferably mounted and removed in the horizontal position.
- the removal side of the container is inclined to a removal region, so that the removal region is always located at the lowest point of the container.
- the extraction pivot axis is disposed at a pivot axis angle of about 1 ° to about 15 °, more preferably about 3 ° to about 10 °, to the predetermined line.
- a pivot axis angle of about 1 ° to about 15 °, preferably about 3 ° to about 10 °, is particularly advantageous for the collection of products in the removal area and for easy positioning of the container on the container carrier.
- the moving device is designed to move the container carrier back and forth about a substantially horizontal rocking axis, wherein the rocking axis is arranged substantially parallel to the predetermined line.
- the container support is first about 2 ° to 15 ° to inclined horizontal plane, and then inclined in the opposite direction by about 2 ° to 15 ° to the horizontal plane.
- This movement of the container carrier may be carried out repeatedly and transferred to the container, so that a constant wave movement of the contents of the container can be generated.
- the rocking axis can be predetermined by the movement device.
- the rocking axis is preferably arranged centrally relative to the container carrier or the container positioned thereon so that the distance traveled in the vertical direction of the removal side during the tilting movement corresponds approximately to the distance traveled in the vertical direction of the removal side opposite side of the container.
- the rocking axis may be spaced from the receiving surface of the container carrier in the vertical direction.
- the rocking axis is arranged substantially parallel to the predetermined line, so that the removal pivot axis can also be defined with respect to the rocking axis, namely that the removal pivot axis at an angle of about 0 ° to 45 °, preferably about 1 ° to about 15 °, more preferably about 3 ° to about 10 °, is arranged to Wippachse.
- the movement device comprises a movable coupling element, which is connected for moving the container carrier with the container carrier, wherein the container carrier is pivotally mounted about the removal pivot axis on the coupling element, so that the container carrier by means of a pivoting movement can be moved from a mixed layer into a picking situation.
- the coupling element can be driven or moved by a drive of the movement device.
- the coupling member may project upwardly from a base of the moving device.
- the container carrier is connected via the coupling element with the movement device, so that the movement of the coupling element can be transferred to the container carrier and further to the container.
- the positioning device has at least one clamping rail, which extends substantially along the predetermined line or parallel thereto.
- one side of the container in particular in the case of a foil bag, can be fixed to the container carrier by means of the clamping rail.
- a clamping rail is provided on the withdrawal side of the container and a clamping rail on the side opposite the removal side of the container.
- the container may have at the appropriate locations tabs or rails that can cooperate with the clamping rails.
- the container has in its periphery on at least two sides via tabs inserted into tabs or rods which correspond to the clamping rails of the container carrier and are clamped by these. The container is held using the rods fixed in the clamping rails.
- the stable rods or rods are preferably made of plastic.
- the positioning device has at least one attachment hook, which is arranged substantially along the predetermined line or parallel thereto.
- the attachment hook enables a particularly simple fixing of one side of the container to the container carrier.
- the attachment hook may have a widthwise extending shape and / or a plurality of attachment hooks may be disposed along the predetermined line or parallel thereto.
- a fastening hook is provided on the withdrawal side of the container and a fastening hook on the side opposite the removal side of the container.
- the container may have recesses, in particular holes and / or slots, into which the attachment hook or hooks can be inserted.
- the container carrier is trough-shaped, and an inner edge of the trough-shaped container carrier extends substantially along the vorerirrimten line or parallel thereto.
- the trough shape of the container carrier allows a particularly good support in containers in the form of foil bags, since these in the filled and inflated Condition may have a support surface corresponding to the tub shape. Furthermore, the trough shape enables a good lateral support of the container, which is important during the mixing movement and when setting up. In the case of leaks, a closed tray offers additional security against further spreading contamination with the fluid from the container. Since the container in this case bears against the trough-shaped receiving surface of the container carrier, the inner edge of the container carrier extends along the predetermined line or parallel thereto. In a further embodiment, the trough-shaped container carrier is open at one or more corners, so that in these areas convenient supply and / or discharge lines and connections for various sensor elements can be performed.
- the coupling element has a support region which abuts against and supports a lower side of the container carrier when the container positionable on the container carrier is in the mixing position.
- the support area of the coupling element constitutes a stop for the container carrier when the container carrier is moved from the removal position into the mixing position.
- the support area of the container carrier is aligned in the mixed position substantially horizontally.
- the container carrier is supported on the one hand by the pivot bearing between the container carrier and coupling element and by the support region of the coupling element.
- the coupling element is formed substantially plate-shaped, wherein the removal pivot axis is arranged at one end of the plate-shaped coupling element.
- Substantially plate-shaped means that the coupling element has a planar design.
- the coupling element may have recesses or be a frame construction.
- the plate-shaped coupling element is oriented substantially to the horizontal plane, and at one end of the coupling element, the removal pivot axis or the pivot bearing is arranged.
- the container carrier can with his Base on the coupling element, in particular the support area thereof, abut, wherein the container carrier is aligned parallel to the coupling element.
- the mixing device comprises an erection mechanism, which makes it possible to determine the container carrier in a predetermined or predeterminable setting angle relative to the movement device.
- the erection mechanism is preferably connected to the coupling element and makes it possible to set up and / or determine the container carrier in a predetermined or predeterminable setting angle relative to the coupling element.
- the erection mechanism can be hydraulically, pneumatically and / or electrically driven and allow setting up and / or fixing of the container carrier in a predetermined or predeterminable setting angle.
- the erection mechanism is preferably arranged between the coupling element and the container carrier.
- the deployment mechanism comprises a locking lever which is pivotally mounted on the moving device and which supports the container support when the container positionable on the container carrier is in the removal position.
- the locking lever is preferably arranged pivotably on the coupling element.
- the locking lever allows a particularly simple deployment mechanism, since the container support, in particular the underside thereof, does not need to be specially configured.
- the locking lever In the mixing position, the locking lever is aligned substantially horizontally and substantially in the same plane as the container carrier and / or the coupling element.
- pivoting the locking lever of the container support is raised and placed pivoting about the removal pivot axis, wherein the locking lever slides on the underside of the container support along.
- the pivot axis of the locking lever is arranged approximately parallel to the removal pivot axis.
- FIG. 1 shows a mixing device according to an embodiment in a perspective view.
- Fig. 5 the mixing device in a plan view.
- Fig. 1 shows a mixing device 1 according to an embodiment in a perspective view.
- the mixing device 1 comprises a container carrier 3, which is arranged on a movement device 5.
- the movement device 5 comprises a base 7 and a coupling element 9.
- the container carrier 3 is connected to the coupling element 9 and pivotally mounted on a removal pivot axis at this.
- the removal pivot axis is not shown in Fig. 1.
- the container support 3 is inclined to the horizontal plane and therefore not in the mixed position but in the removal position or a Eiseniage between the mixed layer and the removal position.
- the container carrier 3 is plate-shaped or trough-shaped and has in its lower and upper regions in each case a depression or recess 33.
- the recess 33 serves to receive sensors, but may also have passages for the passage of lines and / or cables.
- FIG. 2 and FIG. 3 each show the mixing device 1 in a front view, wherein a container 12 in the form of a foil bag or bioreactor bag on the Container carrier 3 is arranged.
- the positioning device 11 is shown, in Fig. 2, this is hidden.
- the container 12 is positioned with two opposite ends 15 by means of the positioning device 1 on the container carrier 3 or attached.
- the container 12 is fastened in the form of clamping bars by means of flexible rods 35 (also called “rods") which are inserted in tabs at the ends of the container 12 and the positioning device 11.
- the clamping bars 35 can be made in FIG
- the position of the container 12 on the container carrier 3 and the removal side 17 of the container 12 are predetermined by the positioning device 11, in particular in interaction with the clamping bars 35 is disposed along the predetermined line 19 of the container support 3.
- the removal pivot axis 21 is inclined with respect to the predetermined line 19 and the removal side 17. However, from the angle of view given in Figures 2 and 3, the exact pivot axis angle is not discernible This would only be recognizable if the container carrier 3 were positioned perpendicular to the horizontal plane w earth, that is perpendicular to the viewing direction in Fig. 2 and Fig. 3 would be arranged.
- the removal pivot axis 21 is aligned horizontally.
- the removal pivot axis 21 is predetermined by the pivot bearing between the container carrier 3 and the coupling element 9. If no mixing movement is carried out, the removal pivot axis 21 is fixed, in particular the removal pivot axis 21 does not move when the container carrier 3 is displaced from the mixing position into the removal position.
- the container carrier 3 in the removal position or the intermediate layer, ie, the container 12 is in the removal position or in a pregnantsteiiung.
- the removal side 17 is inclined to the horizontal plane, in particular inclined to the removal region 23 out.
- Fig. 4 shows the mixing device 1 in a further perspective view from another angle.
- the coupling element 9 is plate-shaped and is mounted about the tilting axis 25 pivotally mounted on the base 7 of the moving device 5.
- the drive 27 generates a tilting movement of the coupling element 9 about the tilting axis 25 for generating the mixing movement.
- the removal pivot axis 21 is arranged on a cross to the Tilting axis 25 lying end of the coupling element 9.
- the removal pivot axis 21 and the tilt axis 25 are thus in the same horizontal plane.
- the removal pivot axis 21, however, is inclined about the pivot axis angle to the tilt axis 25.
- the removal pivot axis 21 is also inclined to the predetermined line, not shown, about the pivot axis angle.
- the mixing device 1 In the mixed position, the predetermined line and the tilting axis 25 are arranged parallel to each other.
- the underside of the container carrier 3 rests on the support region 31 of the coupling element 9 and is supported by it.
- the mixing device 1 has an erection mechanism 29 in the form of a gas pressure spring 29.
- the gas spring 29 is attached at one end to the coupling element 9 and at the other end to the underside of the container carrier 3.
- Fig. 5 shows the mixing device 1 in a plan view.
- the removal pivot axis 21 is arranged inclined to the tilt axis 25 about the pivot axis angle.
- the gas spring 29 is oriented such that by linear method of the gas spring 29, the container carrier 3 can be moved from the mixed layer into the removal position.
- the gas spring 29 in the initial position ie when the container carrier 3 is in the mixed position and the gas spring 29 is arranged parallel to the coupling element 9 in the horizontal plane, inclined approximately to the pivot axis angle to a line which is perpendicular to the tilt axis 25 and / or the predetermined line is.
- the gas spring-pivot axis is arranged approximately parallel to the removal pivot axis 21.
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14002424.1A EP2975111B1 (de) | 2014-07-14 | 2014-07-14 | Mischvorrichtung zum Mischen eines Inhalts eines Behälters |
PCT/EP2015/000992 WO2016008556A1 (de) | 2014-07-14 | 2015-05-13 | Mischvorrichtung zum mischen eines inhalts eines behälters |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3129459A1 true EP3129459A1 (de) | 2017-02-15 |
Family
ID=51211482
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14002424.1A Active EP2975111B1 (de) | 2014-07-14 | 2014-07-14 | Mischvorrichtung zum Mischen eines Inhalts eines Behälters |
EP15724173.8A Withdrawn EP3129459A1 (de) | 2014-07-14 | 2015-05-13 | Mischvorrichtung zum mischen eines inhalts eines behälters |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14002424.1A Active EP2975111B1 (de) | 2014-07-14 | 2014-07-14 | Mischvorrichtung zum Mischen eines Inhalts eines Behälters |
Country Status (4)
Country | Link |
---|---|
US (1) | US10428299B2 (de) |
EP (2) | EP2975111B1 (de) |
CN (1) | CN106574219B (de) |
WO (1) | WO2016008556A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10617070B2 (en) * | 2014-10-06 | 2020-04-14 | Life Technologies Corporation | Methods and systems for culturing microbial and cellular seed cultures |
EP3620506A1 (de) | 2018-09-05 | 2020-03-11 | Sartorius Stedim Switzerland AG | Erntevorrichtung und verfahren zum ernten des inhalts eines bioreaktorbeutels |
US20200148987A1 (en) * | 2018-11-13 | 2020-05-14 | Ge Healthcare Bio-Sciences Corp. | Apparatus, system and method for bioprocessing |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2667393B1 (fr) * | 1990-10-01 | 1994-12-23 | Alain Fillaud | Dispositif de pesee et d'agitation simultanee. |
US6190913B1 (en) * | 1997-08-12 | 2001-02-20 | Vijay Singh | Method for culturing cells using wave-induced agitation |
CH697035A5 (de) * | 1999-05-04 | 2008-03-31 | Marcel Roell | Bioreaktor. |
BE1016538A3 (fr) * | 2004-02-20 | 2007-01-09 | Cesco Bioengineering Co Ltd | Appareil et procede pour la preparation et la mise en culture de cellules. |
US9738863B2 (en) * | 2011-02-23 | 2017-08-22 | Ge Healthcare Bio-Sciences Ab | Bioreactor including a rocking device |
EP2639294A1 (de) * | 2012-03-15 | 2013-09-18 | CellProthera | Automat und automatisiertes Verfahren zur Herstellung von Zellkulturen |
-
2014
- 2014-07-14 EP EP14002424.1A patent/EP2975111B1/de active Active
-
2015
- 2015-05-13 EP EP15724173.8A patent/EP3129459A1/de not_active Withdrawn
- 2015-05-13 CN CN201580038081.7A patent/CN106574219B/zh active Active
- 2015-05-13 WO PCT/EP2015/000992 patent/WO2016008556A1/de active Application Filing
- 2015-05-13 US US15/325,520 patent/US10428299B2/en active Active
Non-Patent Citations (2)
Title |
---|
None * |
See also references of WO2016008556A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2016008556A1 (de) | 2016-01-21 |
EP2975111A1 (de) | 2016-01-20 |
EP2975111B1 (de) | 2018-05-16 |
US20170159001A1 (en) | 2017-06-08 |
CN106574219A (zh) | 2017-04-19 |
US10428299B2 (en) | 2019-10-01 |
CN106574219B (zh) | 2018-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE102006062714B4 (de) | Vorrichtung zum Mischen von Laborgefäß-Inhalten | |
EP1715312B1 (de) | Waage mit einem Windschutz | |
EP2205716B1 (de) | Mikroreaktor | |
EP2388561B1 (de) | Laborgerät zur Probenvorbereitung | |
DE60211760T2 (de) | Vorrichtung und Verfahren zum parallelen Verarbeiten einer Vielzahl von Reaktionsgemischen | |
EP1110609B1 (de) | System zur Bearbeitung von Proben in einer Mehrkammeranordnung | |
EP2117691B1 (de) | Mehrplatzmischvorrichtung zum mischen von laborgefässinhalten | |
EP2975111B1 (de) | Mischvorrichtung zum Mischen eines Inhalts eines Behälters | |
DE102006030056B3 (de) | Mikrotiterplatte mit Rührelementen | |
EP1445307B1 (de) | Schüttel-Inkubator | |
DE10232202B4 (de) | Probenbehandlungsstation | |
DE3836216A1 (de) | Verfahren und vorrichtung zum mischen von pulverfoermigen bis koernigen schuettguetern | |
EP3479894B1 (de) | Schüttler | |
EP3080614B1 (de) | Probenmanipulationseinrichtung | |
EP1478793B1 (de) | Vorrichtung zur erzeugung von hängenden tropfen und zugehöriges verfahren | |
DE102020000046A1 (de) | Rührvorrichtung | |
DE2913989C2 (de) | Probenbehälteranordnung mit einem Probenbehälterträger, in welchem mehrere Probenbehälter entnehmbar an bestimmten Plätzen angeordnet sind | |
EP3927454A1 (de) | Verfahren und vorrichtung zur durchführung von reaktionsprozessen | |
EP3932532A1 (de) | Mischapparat, mischanlage und verfahren zum mischen von substanzen in geschlossenen behältern | |
LU100170B1 (de) | Verfahren zum Prozessieren einer flüssigen Probe | |
WO1998057740A1 (de) | Vorrichtung zur temperierung von gasen, flüssigkeiten und/oder feststoffen in einem reaktionsgefäss | |
DE102010019776B4 (de) | Klimaschrank mit mehreren Ein- und Ausgabestationen | |
DE102006011371A1 (de) | Vorrichtung zum Mischen insbesondere von Laborgefäß-Inhalten | |
DE3346003A1 (de) | Wanne oder becken, insbesondere fuer mit hilfe von sogenannten mehrfachpipetten zu pipettierende bzw. zu entnehmende fluessigkeiten | |
DE102021200359A1 (de) | Halteklemme zum halten einer eckigen flasche auf einer schüttelplattform einer laborschütteleinrichtung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20161109 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ROELL, MARCEL Inventor name: HOEPLI, DANIEL |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20181127 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20190409 |