EP3129027A4 - Modulatoren von caspase-6 - Google Patents

Modulatoren von caspase-6 Download PDF

Info

Publication number
EP3129027A4
EP3129027A4 EP15829650.9A EP15829650A EP3129027A4 EP 3129027 A4 EP3129027 A4 EP 3129027A4 EP 15829650 A EP15829650 A EP 15829650A EP 3129027 A4 EP3129027 A4 EP 3129027A4
Authority
EP
European Patent Office
Prior art keywords
caspase
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15829650.9A
Other languages
English (en)
French (fr)
Other versions
EP3129027A1 (de
Inventor
Medhi Mike KHANKISCHPUR
Olga PETINA
Detlef Geffken
Dagmar ERNHOEFER
Michael Hayden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Universitaet Hamburg
Original Assignee
University of British Columbia
Universitaet Hamburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia, Universitaet Hamburg filed Critical University of British Columbia
Publication of EP3129027A1 publication Critical patent/EP3129027A1/de
Publication of EP3129027A4 publication Critical patent/EP3129027A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/28—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups acylated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP15829650.9A 2014-02-14 2015-02-14 Modulatoren von caspase-6 Withdrawn EP3129027A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461939922P 2014-02-14 2014-02-14
US201462033401P 2014-08-05 2014-08-05
PCT/IB2015/000144 WO2016020732A1 (en) 2014-08-05 2015-02-14 Modulators of caspase-6

Publications (2)

Publication Number Publication Date
EP3129027A1 EP3129027A1 (de) 2017-02-15
EP3129027A4 true EP3129027A4 (de) 2017-06-21

Family

ID=55263221

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15829650.9A Withdrawn EP3129027A4 (de) 2014-02-14 2015-02-14 Modulatoren von caspase-6

Country Status (6)

Country Link
EP (1) EP3129027A4 (de)
JP (1) JP2018522812A (de)
AU (1) AU2015298491A1 (de)
CA (1) CA2939655A1 (de)
DE (1) DE112015001269T5 (de)
WO (1) WO2016020732A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2977947A1 (en) 2015-03-06 2016-09-15 Pharmakea, Inc. Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
ES2872553T3 (es) 2015-03-06 2021-11-02 Pharmakea Inc Inhibidores de lisil oxidasa tipo-2 y usos de los mismos
CA3013917A1 (en) 2016-02-09 2017-08-17 Pharmakea, Inc. Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
EP4052707A1 (de) 2016-09-07 2022-09-07 Pharmakea, Inc. Verwendung eines lysyloxidase-ähnlichen 2-inhibitors
BR112019004517A2 (pt) 2016-09-07 2019-08-13 Pharmakea Inc formas cristalinas de um inibidor lisil-oxidase-semelhante 2 e métodos de preparação
KR20220159346A (ko) * 2019-11-22 2022-12-02 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 카스파제 6 억제제 및 이의 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017408A1 (en) * 2008-08-06 2010-02-11 The Buck Institute For Age Research Caspase inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0818439B1 (de) * 1996-07-02 1999-10-13 Nisshin Flour Milling Co., Ltd. Imid derivate
JP5342450B2 (ja) * 2006-12-15 2013-11-13 ブリストル−マイヤーズ スクイブ カンパニー 第ＸＩａ因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017408A1 (en) * 2008-08-06 2010-02-11 The Buck Institute For Age Research Caspase inhibitors and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIETER HUBMANN ET AL: "N-(3-Phenyl-2-propynoyl)benzamide", MOLECULES, 1 January 1999 (1999-01-01), pages M107, XP055372338, Retrieved from the Internet <URL:http://www.mdpi.org/molbank/m0107.htm> [retrieved on 20170512] *
NILOUFAR ANSARI ET AL: "Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-B pathway and regulation of cellular redox status by an oxazine derivative", BIOCHIMIE, MASSON, PARIS, FR, vol. 93, no. 5, 20 November 2011 (2011-11-20), pages 899 - 908, XP028192107, ISSN: 0300-9084, [retrieved on 20110202], DOI: 10.1016/J.BIOCHI.2011.01.012 *
OLGA PETINA ET AL: "Preparation of Arylpropynamides and Their Reaction with Malonyl Acid Derivatives", SYNTHESIS, vol. 45, no. 06, 15 February 2013 (2013-02-15), STUTTGART, DE., pages 803 - 809, XP055372325, ISSN: 0039-7881, DOI: 10.1055/s-0032-1316851 *
RONA K GRAHAM ET AL: "Caspase-6 and neurodegeneration", TRENDS IN NEUROSCIENCE, vol. 34, no. 12, December 2011 (2011-12-01), pages 646 - 656, XP028119167, ISSN: 0166-2236, [retrieved on 20110917], DOI: 10.1016/J.TINS.2011.09.001 *

Also Published As

Publication number Publication date
EP3129027A1 (de) 2017-02-15
JP2018522812A (ja) 2018-08-16
CA2939655A1 (en) 2016-02-11
DE112015001269T5 (de) 2017-06-08
WO2016020732A1 (en) 2016-02-11
AU2015298491A1 (en) 2016-09-01

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A4 Supplementary search report drawn up and despatched

Effective date: 20170523

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/535 20060101AFI20170517BHEP

Ipc: A61P 25/14 20060101ALI20170517BHEP

Ipc: C07D 265/06 20060101ALI20170517BHEP

Ipc: A61K 31/165 20060101ALI20170517BHEP

Ipc: C07C 251/28 20060101ALI20170517BHEP

Ipc: A61P 25/28 20060101ALI20170517BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GEFFKEN, DETLEF

Inventor name: KHANKISCHPUR, MEDHI, MIKE

Inventor name: HAYDEN, MICHAEL

Inventor name: ERNHOEFER, DAGMAR

Inventor name: PETINA, OLGA

STAA Information on the status of an ep patent application or granted ep patent

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RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 251/28 20060101ALI20180122BHEP

Ipc: A61P 25/28 20060101ALI20180122BHEP

Ipc: A61P 25/14 20060101ALI20180122BHEP

Ipc: A61K 31/165 20060101ALI20180122BHEP

Ipc: A61K 45/06 20060101ALI20180122BHEP

Ipc: C07D 265/06 20060101ALI20180122BHEP

Ipc: A61K 31/535 20060101AFI20180122BHEP

18W Application withdrawn

Effective date: 20180209