EP3129027A4 - Modulateurs de caspase 6 - Google Patents
Modulateurs de caspase 6 Download PDFInfo
- Publication number
- EP3129027A4 EP3129027A4 EP15829650.9A EP15829650A EP3129027A4 EP 3129027 A4 EP3129027 A4 EP 3129027A4 EP 15829650 A EP15829650 A EP 15829650A EP 3129027 A4 EP3129027 A4 EP 3129027A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- caspase
- modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/28—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups acylated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461939922P | 2014-02-14 | 2014-02-14 | |
US201462033401P | 2014-08-05 | 2014-08-05 | |
PCT/IB2015/000144 WO2016020732A1 (fr) | 2014-08-05 | 2015-02-14 | Modulateurs de caspase 6 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3129027A1 EP3129027A1 (fr) | 2017-02-15 |
EP3129027A4 true EP3129027A4 (fr) | 2017-06-21 |
Family
ID=55263221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15829650.9A Withdrawn EP3129027A4 (fr) | 2014-02-14 | 2015-02-14 | Modulateurs de caspase 6 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3129027A4 (fr) |
JP (1) | JP2018522812A (fr) |
AU (1) | AU2015298491A1 (fr) |
CA (1) | CA2939655A1 (fr) |
DE (1) | DE112015001269T5 (fr) |
WO (1) | WO2016020732A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016144702A1 (fr) | 2015-03-06 | 2016-09-15 | Pharmakea, Inc. | Inhibiteurs de la lysyl oxydase-like 2 et utilisations desdits inhibiteurs |
KR102594441B1 (ko) | 2015-03-06 | 2023-10-25 | 파마케아, 인크. | 플루오르화된 리실 옥시다아제-유사 2 억제제 및 이의 용도 |
WO2017139274A1 (fr) | 2016-02-09 | 2017-08-17 | Pharmakea, Inc. | Inhibiteurs quinolinone de la lysyl oxydase-like 2 et utilisations desdits inhibiteurs |
KR20230162996A (ko) | 2016-09-07 | 2023-11-29 | 파마케아, 인크. | 리실 옥시다제 유사 2 억제제의 용도 |
SG11201901999XA (en) | 2016-09-07 | 2019-04-29 | Pharmakea Inc | Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making |
CN115335039A (zh) * | 2019-11-22 | 2022-11-11 | 加利福尼亚大学董事会 | 胱天蛋白酶6抑制剂和其用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010017408A1 (fr) * | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Inhibiteurs de caspase, et leurs utilisations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69700616T2 (de) * | 1996-07-02 | 2000-03-16 | Nisshin Flour Milling Co., Ltd. | Imid derivate |
US8410155B2 (en) * | 2006-12-15 | 2013-04-02 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors |
-
2015
- 2015-02-14 DE DE112015001269.9T patent/DE112015001269T5/de not_active Withdrawn
- 2015-02-14 AU AU2015298491A patent/AU2015298491A1/en not_active Abandoned
- 2015-02-14 CA CA2939655A patent/CA2939655A1/fr not_active Abandoned
- 2015-02-14 WO PCT/IB2015/000144 patent/WO2016020732A1/fr active Application Filing
- 2015-02-14 EP EP15829650.9A patent/EP3129027A4/fr not_active Withdrawn
- 2015-02-14 JP JP2016552512A patent/JP2018522812A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010017408A1 (fr) * | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Inhibiteurs de caspase, et leurs utilisations |
Non-Patent Citations (4)
Title |
---|
DIETER HUBMANN ET AL: "N-(3-Phenyl-2-propynoyl)benzamide", MOLECULES, 1 January 1999 (1999-01-01), pages M107, XP055372338, Retrieved from the Internet <URL:http://www.mdpi.org/molbank/m0107.htm> [retrieved on 20170512] * |
NILOUFAR ANSARI ET AL: "Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-B pathway and regulation of cellular redox status by an oxazine derivative", BIOCHIMIE, MASSON, PARIS, FR, vol. 93, no. 5, 20 November 2011 (2011-11-20), pages 899 - 908, XP028192107, ISSN: 0300-9084, [retrieved on 20110202], DOI: 10.1016/J.BIOCHI.2011.01.012 * |
OLGA PETINA ET AL: "Preparation of Arylpropynamides and Their Reaction with Malonyl Acid Derivatives", SYNTHESIS, vol. 45, no. 06, 15 February 2013 (2013-02-15), STUTTGART, DE., pages 803 - 809, XP055372325, ISSN: 0039-7881, DOI: 10.1055/s-0032-1316851 * |
RONA K GRAHAM ET AL: "Caspase-6 and neurodegeneration", TRENDS IN NEUROSCIENCE, vol. 34, no. 12, December 2011 (2011-12-01), pages 646 - 656, XP028119167, ISSN: 0166-2236, [retrieved on 20110917], DOI: 10.1016/J.TINS.2011.09.001 * |
Also Published As
Publication number | Publication date |
---|---|
JP2018522812A (ja) | 2018-08-16 |
AU2015298491A1 (en) | 2016-09-01 |
EP3129027A1 (fr) | 2017-02-15 |
WO2016020732A1 (fr) | 2016-02-11 |
CA2939655A1 (fr) | 2016-02-11 |
DE112015001269T5 (de) | 2017-06-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20160818 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20170523 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/535 20060101AFI20170517BHEP Ipc: A61P 25/14 20060101ALI20170517BHEP Ipc: C07D 265/06 20060101ALI20170517BHEP Ipc: A61K 31/165 20060101ALI20170517BHEP Ipc: C07C 251/28 20060101ALI20170517BHEP Ipc: A61P 25/28 20060101ALI20170517BHEP |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: GEFFKEN, DETLEF Inventor name: KHANKISCHPUR, MEDHI, MIKE Inventor name: HAYDEN, MICHAEL Inventor name: ERNHOEFER, DAGMAR Inventor name: PETINA, OLGA |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 251/28 20060101ALI20180122BHEP Ipc: A61P 25/28 20060101ALI20180122BHEP Ipc: A61P 25/14 20060101ALI20180122BHEP Ipc: A61K 31/165 20060101ALI20180122BHEP Ipc: A61K 45/06 20060101ALI20180122BHEP Ipc: C07D 265/06 20060101ALI20180122BHEP Ipc: A61K 31/535 20060101AFI20180122BHEP |
|
18W | Application withdrawn |
Effective date: 20180209 |