EP3129027A4 - Modulateurs de caspase 6 - Google Patents

Modulateurs de caspase 6 Download PDF

Info

Publication number
EP3129027A4
EP3129027A4 EP15829650.9A EP15829650A EP3129027A4 EP 3129027 A4 EP3129027 A4 EP 3129027A4 EP 15829650 A EP15829650 A EP 15829650A EP 3129027 A4 EP3129027 A4 EP 3129027A4
Authority
EP
European Patent Office
Prior art keywords
caspase
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15829650.9A
Other languages
German (de)
English (en)
Other versions
EP3129027A1 (fr
Inventor
Medhi Mike KHANKISCHPUR
Olga PETINA
Detlef Geffken
Dagmar ERNHOEFER
Michael Hayden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Universitaet Hamburg
Original Assignee
University of British Columbia
Universitaet Hamburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia, Universitaet Hamburg filed Critical University of British Columbia
Publication of EP3129027A1 publication Critical patent/EP3129027A1/fr
Publication of EP3129027A4 publication Critical patent/EP3129027A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/28—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups acylated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP15829650.9A 2014-02-14 2015-02-14 Modulateurs de caspase 6 Withdrawn EP3129027A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461939922P 2014-02-14 2014-02-14
US201462033401P 2014-08-05 2014-08-05
PCT/IB2015/000144 WO2016020732A1 (fr) 2014-08-05 2015-02-14 Modulateurs de caspase 6

Publications (2)

Publication Number Publication Date
EP3129027A1 EP3129027A1 (fr) 2017-02-15
EP3129027A4 true EP3129027A4 (fr) 2017-06-21

Family

ID=55263221

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15829650.9A Withdrawn EP3129027A4 (fr) 2014-02-14 2015-02-14 Modulateurs de caspase 6

Country Status (6)

Country Link
EP (1) EP3129027A4 (fr)
JP (1) JP2018522812A (fr)
AU (1) AU2015298491A1 (fr)
CA (1) CA2939655A1 (fr)
DE (1) DE112015001269T5 (fr)
WO (1) WO2016020732A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144702A1 (fr) 2015-03-06 2016-09-15 Pharmakea, Inc. Inhibiteurs de la lysyl oxydase-like 2 et utilisations desdits inhibiteurs
KR102594441B1 (ko) 2015-03-06 2023-10-25 파마케아, 인크. 플루오르화된 리실 옥시다아제-유사 2 억제제 및 이의 용도
WO2017139274A1 (fr) 2016-02-09 2017-08-17 Pharmakea, Inc. Inhibiteurs quinolinone de la lysyl oxydase-like 2 et utilisations desdits inhibiteurs
KR20230162996A (ko) 2016-09-07 2023-11-29 파마케아, 인크. 리실 옥시다제 유사 2 억제제의 용도
SG11201901999XA (en) 2016-09-07 2019-04-29 Pharmakea Inc Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
CN115335039A (zh) * 2019-11-22 2022-11-11 加利福尼亚大学董事会 胱天蛋白酶6抑制剂和其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017408A1 (fr) * 2008-08-06 2010-02-11 The Buck Institute For Age Research Inhibiteurs de caspase, et leurs utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69700616T2 (de) * 1996-07-02 2000-03-16 Nisshin Flour Milling Co., Ltd. Imid derivate
US8410155B2 (en) * 2006-12-15 2013-04-02 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017408A1 (fr) * 2008-08-06 2010-02-11 The Buck Institute For Age Research Inhibiteurs de caspase, et leurs utilisations

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIETER HUBMANN ET AL: "N-(3-Phenyl-2-propynoyl)benzamide", MOLECULES, 1 January 1999 (1999-01-01), pages M107, XP055372338, Retrieved from the Internet <URL:http://www.mdpi.org/molbank/m0107.htm> [retrieved on 20170512] *
NILOUFAR ANSARI ET AL: "Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-B pathway and regulation of cellular redox status by an oxazine derivative", BIOCHIMIE, MASSON, PARIS, FR, vol. 93, no. 5, 20 November 2011 (2011-11-20), pages 899 - 908, XP028192107, ISSN: 0300-9084, [retrieved on 20110202], DOI: 10.1016/J.BIOCHI.2011.01.012 *
OLGA PETINA ET AL: "Preparation of Arylpropynamides and Their Reaction with Malonyl Acid Derivatives", SYNTHESIS, vol. 45, no. 06, 15 February 2013 (2013-02-15), STUTTGART, DE., pages 803 - 809, XP055372325, ISSN: 0039-7881, DOI: 10.1055/s-0032-1316851 *
RONA K GRAHAM ET AL: "Caspase-6 and neurodegeneration", TRENDS IN NEUROSCIENCE, vol. 34, no. 12, December 2011 (2011-12-01), pages 646 - 656, XP028119167, ISSN: 0166-2236, [retrieved on 20110917], DOI: 10.1016/J.TINS.2011.09.001 *

Also Published As

Publication number Publication date
JP2018522812A (ja) 2018-08-16
AU2015298491A1 (en) 2016-09-01
EP3129027A1 (fr) 2017-02-15
WO2016020732A1 (fr) 2016-02-11
CA2939655A1 (fr) 2016-02-11
DE112015001269T5 (de) 2017-06-08

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A4 Supplementary search report drawn up and despatched

Effective date: 20170523

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/535 20060101AFI20170517BHEP

Ipc: A61P 25/14 20060101ALI20170517BHEP

Ipc: C07D 265/06 20060101ALI20170517BHEP

Ipc: A61K 31/165 20060101ALI20170517BHEP

Ipc: C07C 251/28 20060101ALI20170517BHEP

Ipc: A61P 25/28 20060101ALI20170517BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GEFFKEN, DETLEF

Inventor name: KHANKISCHPUR, MEDHI, MIKE

Inventor name: HAYDEN, MICHAEL

Inventor name: ERNHOEFER, DAGMAR

Inventor name: PETINA, OLGA

STAA Information on the status of an ep patent application or granted ep patent

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Ipc: C07C 251/28 20060101ALI20180122BHEP

Ipc: A61P 25/28 20060101ALI20180122BHEP

Ipc: A61P 25/14 20060101ALI20180122BHEP

Ipc: A61K 31/165 20060101ALI20180122BHEP

Ipc: A61K 45/06 20060101ALI20180122BHEP

Ipc: C07D 265/06 20060101ALI20180122BHEP

Ipc: A61K 31/535 20060101AFI20180122BHEP

18W Application withdrawn

Effective date: 20180209