EP3110795A4 - Neuartiges ökonomisches verfahren für vildagliptin - Google Patents

Neuartiges ökonomisches verfahren für vildagliptin Download PDF

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Publication number
EP3110795A4
EP3110795A4 EP15754784.5A EP15754784A EP3110795A4 EP 3110795 A4 EP3110795 A4 EP 3110795A4 EP 15754784 A EP15754784 A EP 15754784A EP 3110795 A4 EP3110795 A4 EP 3110795A4
Authority
EP
European Patent Office
Prior art keywords
vildagliptin
economic process
novel economic
novel
economic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15754784.5A
Other languages
English (en)
French (fr)
Other versions
EP3110795A1 (de
Inventor
Swapnil Surendra Mohile
Sandeep Rameshrao TAPKIR
Manoj Vinayak PATIL
Ashok Kumar Gangopadhyay
Peter David Nightingale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hikal Ltd
Original Assignee
Hikal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hikal Ltd filed Critical Hikal Ltd
Publication of EP3110795A1 publication Critical patent/EP3110795A1/de
Publication of EP3110795A4 publication Critical patent/EP3110795A4/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/26—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing carboxyl groups by reaction with HCN, or a salt thereof, and amines, or from aminonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EP15754784.5A 2014-02-28 2015-02-24 Neuartiges ökonomisches verfahren für vildagliptin Withdrawn EP3110795A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN708MU2014 2014-02-28
PCT/IB2015/000219 WO2015128718A1 (en) 2014-02-28 2015-02-24 Novel economic process for vildagliptin

Publications (2)

Publication Number Publication Date
EP3110795A1 EP3110795A1 (de) 2017-01-04
EP3110795A4 true EP3110795A4 (de) 2017-10-04

Family

ID=54008237

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15754784.5A Withdrawn EP3110795A4 (de) 2014-02-28 2015-02-24 Neuartiges ökonomisches verfahren für vildagliptin

Country Status (5)

Country Link
EP (1) EP3110795A4 (de)
JP (1) JP2017507934A (de)
KR (1) KR20160127025A (de)
CN (1) CN106029635A (de)
WO (1) WO2015128718A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106432026A (zh) * 2016-09-12 2017-02-22 重庆医科大学 一类对糖尿病具有潜在治疗活性的化合物
CN107033054A (zh) * 2017-06-19 2017-08-11 河北富格药业有限公司 一种维格列汀的合成方法
CN107325010A (zh) * 2017-08-14 2017-11-07 四川众邦制药有限公司 一种金刚烷醇的安全制备方法及装置
WO2021116897A1 (en) * 2019-12-10 2021-06-17 Optimus Drugs (P) Ltd Process for the preparation of vildagliptin
WO2022003405A1 (en) 2020-07-03 2022-01-06 Savoi Guilherme One-pot process to obtain a pyrrolidine-2-carbonitrile intermediate compound and industrial scale telescopic process to prepare (2s)-1-[n-(3-hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile (vildagliptin) using same
CN112279809A (zh) * 2020-09-23 2021-01-29 山东省海洋化工科学研究院 一种2-氰基-4-氟吡啶的制备方法
CN112939837B (zh) * 2021-02-03 2022-07-19 海南通用三洋药业有限公司 一种多相复式连续生产制备维格列汀的方法
CN115108939A (zh) * 2021-03-17 2022-09-27 成都施贝康生物医药科技有限公司 反式-4-[(2-氨基-3,5-二溴苄基)氨基]-金刚烷-1-醇的中间体及制法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008084383A2 (en) * 2007-01-10 2008-07-17 Medichem, S.A. Process for preparing vildagliptin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057144A2 (en) * 2001-12-26 2003-07-17 Guilford Pharmaceuticals Change inhibitors of dipeptidyl peptidase iv
WO2007078990A2 (en) * 2005-12-23 2007-07-12 Zealand Pharma A/S Modified lysine-mimetic compounds
GB2445746A (en) * 2007-01-17 2008-07-23 Texcontor Ets Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying
EP2145873A1 (de) * 2008-06-17 2010-01-20 Commissariat A L'energie Atomique Neue Verbindungen, die eine Schutzaktivität gegen die Wirkung von Toxinen und Viren über einen intrazellulären Wirkungsmechanismus entfalten
WO2011101861A1 (en) * 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
IT1400714B1 (it) * 2010-07-06 2013-06-28 Chemelectiva S R L Processo ed intermedi per la preparazione di un principio attivo.
ITMI20112224A1 (it) * 2011-12-06 2013-06-07 Chemelectiva S R L Nuovo processo ed intermedi per la sintesi di vildagliptin
CN103980175B (zh) * 2013-02-07 2016-06-01 山东威智医药工业有限公司 制备维达列汀的方法
CN103450083B (zh) * 2013-09-13 2015-12-23 杭州华东医药集团新药研究院有限公司 格尔德霉素衍生物及其制备方法和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008084383A2 (en) * 2007-01-10 2008-07-17 Medichem, S.A. Process for preparing vildagliptin

Also Published As

Publication number Publication date
KR20160127025A (ko) 2016-11-02
CN106029635A (zh) 2016-10-12
EP3110795A1 (de) 2017-01-04
WO2015128718A1 (en) 2015-09-03
JP2017507934A (ja) 2017-03-23

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