EP3019012A1 - Use of selected pyridone carboxamides or salts thereof as active substances against abiotic plant stress - Google Patents

Use of selected pyridone carboxamides or salts thereof as active substances against abiotic plant stress

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Publication number
EP3019012A1
EP3019012A1 EP14737209.8A EP14737209A EP3019012A1 EP 3019012 A1 EP3019012 A1 EP 3019012A1 EP 14737209 A EP14737209 A EP 14737209A EP 3019012 A1 EP3019012 A1 EP 3019012A1
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Prior art keywords
substituted
unsubstituted
alkyl
alkoxy
haloalkoxy
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EP14737209.8A
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German (de)
French (fr)
Inventor
Lars ARVE
Frank Ziemer
Dirk Schmutzler
Jan Dittgen
Ines Heinemann
Martin Jeffrey Hills
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Bayer CropScience AG
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Bayer CropScience AG
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Priority to EP14737209.8A priority Critical patent/EP3019012A1/en
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Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention relates to the use of selected pyridone carboxamides or salts thereof as active substances against abiotic plant stress. The invention also relates to the use of substituted pyridone carboxamides of general formula (I) or the salts thereof, the groups in general formula (I) corresponding to the definitions cited in the description, for increasing the stress tolerance of plants to abiotic stress, for strengthening plant growth and/or for increasing the plant yield. The invention further relates to specific methods for producing said compounds.

Description

Verwendung ausgewählter Pyridoncarboxamide oder deren Salzen als Wirkstoffe gegen abiotischen Pflanzenstress  Use of selected pyridone carboxamides or their salts as active ingredients against abiotic plant stress
Beschreibung description
Die Erfindung betrifft substituierte Pyridoncarboxamide und deren Analoge, Verfahren zu deren Herstellung und ihre Verwendung zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, insbesondere zur Stärkung des The invention relates to substituted pyridone carboxamides and their analogues, to processes for their preparation and to their use for increasing the stress tolerance in plants to abiotic stress, in particular for strengthening the
Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags. Plant growth and / or increase the plant yield.
Es ist bekannt, dass bestimmte Pyridoncarboxamide nutzpflanzenschützende Wirkung gegen Agrochemikalien, welche allein appliziert Schäden an den Nutzpflanzen verursachen, entfalten können (vergl. EP 2008003016). Weiterhin sind Wirkstoffe aus der chemischen Klasse der Pyridone mit Pestiziden Eigenschaften aus der Literatur bekannt. Es werden unterschiedliche biologische Wirkungen beschrieben; so ist z.B. in WO 2001/014339 die fungizide Wirkung bestimmter substituierter Pyridoncarboxamide erwähnt, WO 2005/042492 und WO 2005/042493 beschreiben u.a. die fungizide Wirkung von Heterocyclylcarboxamiden. It is known that certain pyridone carboxamides can develop crop protection activity against agrochemicals which alone cause damage to the crop plants (see EP 2008003016). Furthermore, active substances from the chemical class of pyridones with pesticidal properties are known from the literature. Different biological effects are described; such as e.g. WO 2001/014339 mentions the fungicidal action of certain substituted pyridone carboxamides, WO 2005/042492 and WO 2005/042493 describe inter alia. the fungicidal action of heterocyclylcarboxamides.
EP-A-544151 beschreibt die Wirkung von hydroxysubstituierten Pyridoncarboxamiden als Herbizide.  EP-A-544151 describes the effect of hydroxy-substituted pyridone carboxamides as herbicides.
EP 1 987 717 beschreibt ausgewählte Pyridonderivate sowie deren Verwendung alsSafener, d.h. zur Reduktion phytotoxischer Wirkungen von Agrochemikalien, insbesondere von Herbiziden, an Nutzpflanzen.  EP 1 987 717 describes selected pyridone derivatives and their use as safeners, i. for the reduction of phytotoxic effects of agrochemicals, in particular of herbicides, on useful plants.
WO2001/14339 beschreibt ausgewählte heterocyclische aromatische Amide sowie deren fungizide Wirkung.  WO2001 / 14339 describes selected heterocyclic aromatic amides and their fungicidal action.
WO2013/037955 beschreibt die Verwendung von Verbindungen aus der Gruppe der Acylsulfonamide, insbesondere N-[4-(cyclopropylcarbamoyl)phenylsulfonyl]-2- methoxybenzamide (Cyprosulfamide) zur Ertragssteigerung in Kulturpflanzen, entweder in alleiniger Anwendung oder in kombinierter Anwendung mit Wirkstoffen unterschiedlicher Wirktstoffklassen. Pyridoncarboxamide werden in generischer Form als mögliche Mischungspartner genannt. Weiterhin sind Vertreter mit pharmakologischen Eigenschaften bekannt. So werden in WO 2001/0551 15 Nicotinanilide als Induktoren der Apoptose, in US 2004/01 16479 Dialkylnicotinamide als Inhibitoren der Angiogenese und in JP 2007186434 WO2013 / 037955 describes the use of compounds from the group of acylsulfonamides, in particular N- [4- (cyclopropylcarbamoyl) phenylsulfonyl] -2-methoxybenzamide (Cyprosulfamide) to increase the yield in crops, either alone or in combination with drugs of different classes of agents. Pyridone carboxamides are mentioned in generic form as possible mixing partners. Furthermore, representatives with pharmacological properties are known. Thus, WO 2001/0551 15 discloses nicotinanilides as inducers of apoptosis, in US 2004/01 16479 dialkylnicotinamides as inhibitors of angiogenesis and in JP 2007186434
Pyridinanaloge als vaskuläre endotheliale Stickoxid Promotoren beschrieben. Pyridine analogs described as vascular endothelial nitric oxide promoters.
Ferner beschreibt EP-A-522392 6-Trifluormethyl-substituierte Pyridoncarboxamide als Vorprodukte zur Synthese herbizid wirksamer Sulfonylharnstoffe. In Chemistry of Heterocyclic Compounds, Vol 40, No. 9, 2004, 1 155-1 161 wird N-Benzyl-5,6-dimethyl- 2-oxo-dihydropyridin-3-carboxamid als Reaktionsprodukt beschrieben. Eine Verwendung derartiger Verbindungen zur Erhöhung der Toleranz gegenüber abiotischem, nicht durch Pestizide, bevorzugt nicht durch Herbizide ausgelöstem Stress, in Pflanzen ist noch nicht bekannt. Furthermore, EP-A-522392 describes 6-trifluoromethyl-substituted pyridone carboxamides as precursors for the synthesis of herbicidally active sulfonylureas. In Chemistry of Heterocyclic Compounds, Vol. 9, 2004, 1 155-1 161 N-benzyl-5,6-dimethyl-2-oxo-dihydropyridine-3-carboxamide is described as a reaction product. A use of such compounds to increase the tolerance to abiotic, not by pesticides, preferably not caused by herbicides stress in plants is not yet known.
Es ist bekannt, dass Pflanzen auf natürliche, d.h. nicht durch Pestizide ausgelöste Stressbedingungen, wie beispielsweise Kälte, Hitze, Trockenheit, Verwundung, Pathogenbefall (Viren, Bakterien, Pilze, Insekten) etc. aber auch auf Herbizide mit spezifischen oder unspezifischen Abwehrmechanismen reagieren [Pflanzenbiochemie, S. 393-462 , Spektrum Akademischer Verlag, Heidelberg, Berlin, Oxford, Hans W. Heidt, 1996.; Biochemistry and Molecular Biology of Plants, S. 1 102-1203, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. It is known that plants are naturally, i. not caused by pesticides stress conditions, such as cold, heat, drought, wounding, pathogen infestation (viruses, bacteria, fungi, insects) etc. but also respond to herbicides with specific or nonspecific defense mechanisms [Plant Biochemistry, pp. 393-462, Spektrum Akademischer Verlag , Heidelberg, Berlin, Oxford, Hans W. Heidt, 1996; Biochemistry and Molecular Biology of Plants, p. 1 102-1203, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000].
In Pflanzen sind zahlreiche Proteine und die sie codierenden Gene bekannt, die an Abwehrreaktionen gegen abiotischen Stress (z.B. Kälte, Hitze, Trockenheit, Salz, Überflutung) beteiligt sind. Diese gehören teilweise zu Signaltransduktionsketten (z.B. Transkriptionsfaktoren, Kinasen, Phosphatasen) oder bewirken eine physiologische Antwort der Pflanzenzelle (z.B. lonentransport, Entgiftung reaktiver Sauerstoff- Spezies). Zu den Signalkettengenen der abiotischen Stressreaktion gehören u.a. In plants, numerous proteins and the genes encoding them are involved, which are involved in abiotic stress defense reactions (e.g., cold, heat, drought, salt, flooding). These partially belong to signal transduction chains (e.g., transcription factors, kinases, phosphatases) or cause a physiological response of the plant cell (e.g., ion transport, detoxification of reactive oxygen species). The signal chain genes of the abiotic stress reaction include, among others.
Transkriptionsfaktoren der Klassen DREB und CBF (Jaglo-Ottosen et al., 1998, Science 280: 104-106). An der Reaktion auf Salzstress sind Phosphatasen vom Typ ATPK und MP2C beteiligt. Ferner wird bei Salzstress häufig die Biosynthese von Osmolyten wie Prolin oder Sucrose aktiviert. Beteiligt sind hier z.B. die Sucrose- Synthase und Prolin-Transporter (Hasegawa et al., 2000, Annu Rev Plant Physiol Plant Mol Biol 51 : 463-499). Die Stressabwehr der Pflanzen gegen Kälte und Trockenheit benutzt z.T. die gleichen molekularen Mechanismen. Bekannt ist die Akkumulation von sogenannten Late Embryogenesis Abundant Proteins (LEA- Proteine), zu denen als wichtige Klasse die Dehydrine gehören (Ingram and Bartels, 1996, Annu Rev Plant Physiol Plant Mol Biol 47: 277-403, Close, 1997, Physiol Plant 100: 291 -296). Es handelt sich dabei um Chaperone, die Vesikel, Proteine und Transcription factors of classes DREB and CBF (Jaglo-Ottosen et al., 1998, Science 280: 104-106). The response to salt stress involves phosphatases of the ATPK and MP2C types. Furthermore, in salt stress the biosynthesis of osmolytes such as proline or sucrose is often activated. For example, sucrose synthase and proline transporters are involved here (Hasegawa et al., 2000, Annu Rev Plant Physiol Plant Mol Biol 51: 463-499). The stress control of plants against cold and Dryness partly uses the same molecular mechanisms. The accumulation of so-called Late Embryogenesis Abundant Proteins (LEA proteins), which include dehydrins as an important class, is known (Ingram and Bartels, 1996, Annu Rev Plant Physiol Plant Mol Biol 47: 277-403, Close, 1997, Physiol Plant 100: 291-296). These are chaperones, the vesicles, proteins and
Membranstrukturen in gestressten Pflanzen stabilisieren (Bray, 1993, Plant Physiol 103: 1035-1040). Außerdem erfolgt häufig eine Induktion von Aldehyd- Deydrogenasen, welche die bei oxidativem Stress entstehenden reaktiven Sauerstoff- Spezies (ROS) entgiften (Kirch et al., 2005, Plant Mol Biol 57: 315-332). Stabilize membrane structures in stressed plants (Bray, 1993, Plant Physiol 103: 1035-1040). Moreover, induction of aldehyde dehydrogenases, which detoxify the reactive oxygen species (ROS) produced by oxidative stress, is often used (Kirch et al., 2005, Plant Mol Biol 57: 315-332).
Heat Shock Faktoren (HSF) und Heat Shock Proteine (HSP) werden bei Hitzestress aktiviert und spielen hier als Chaperone eine ähnliche Rolle wie die Dehydrine bei Kälte- und Trockenstress (Yu et al., 2005, Mol Cells 19: 328-333). Heat Shock Factors (HSF) and Heat Shock Proteins (HSP) are activated by heat stress and act as chaperones in a similar role to dehydrins in cold and dry stress (Yu et al., 2005, Mol Cells 19: 328-333).
Eine Reihe pflanzenendogener Signalstoffe, die in die Stresstoleranz bzw. die A series of plant endogenous signaling substances that are in the stress tolerance or the
Pathogenabwehr involviert sind, sind bereits bekannt. Zu nennen sind hier Pathogen defense are already known. To call here are
beispielsweise Salicylsäure, Benzoesäure, Jasmonsäure oder Ethylen [Biochemistry and Molecular Biology of Plants, S. 850-929, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. Einige dieser for example, salicylic acid, benzoic acid, jasmonic acid or ethylene [Biochemistry and Molecular Biology of Plants, pp. 850-929, American Society of Plant Physiologists, Rockville, Maryland, eds. Buchanan, Gruissem, Jones, 2000]. Some of these
Substanzen oder deren stabile synthetische Derivate und abgeleitete Strukturen sind auch bei externer Applikation auf Pflanzen oder Saatgutbeizung wirksam und aktivieren Abwehrreaktionen, die eine erhöhte Stress- bzw. Pathogentoleranz der Pflanze zur Folge haben [Sembdner, and Parthier, 1993, Ann. Rev. Plant Physiol. Plant Mol. Biol. 44: 569-589]. Es ist weiter bekannt, dass chemische Substanzen die Toleranz von Pflanzen gegen abiotischen Stress erhöhen können. Derartige Substanzen werden dabei entweder durch Saatgut-Beizung, durch Blattspritzung oder durch Bodenbehandung appliziert. So wird eine Erhöhung der abiotischen Stresstoleranz von Kulturpflanzen durch Behandlung mit Elicitoren der Systemic Acquired Resistance (SAR) oder Substances or their stable synthetic derivatives and derived structures are also effective in external application to plants or seed dressing and activate defense reactions that result in an increased stress or pathogen tolerance of the plant [Sembdner, and Parthier, 1993, Ann. Rev. Plant Physiol. Plant Mol. Biol. 44: 569-589]. It is also known that chemical substances can increase the tolerance of plants to abiotic stress. Such substances are applied either by seed dressing, by foliar spraying or by soil treatment. Thus, increasing the abiotic stress tolerance of crops by treatment with systemic acquired resistance (SAR) or
Abscisinsäure-Derivaten beschrieben (Schading and Wei, WO-200028055, Abrams and Gusta, US-5201931 , Churchill et al., 1998, Plant Growth Regul 25: 35-45) oder Azibenzolar-S-methyl. Auch bei Anwendung von Fungiziden, insbesondere aus der Gruppe der Strobilurine oder der Succinat-Dehydrogenase-Inhibitoren werden ähnliche Effekte beobachtet, die häufig auch mit einer Ertragssteigerung einhergehen (Draber et al., DE-3534948, Bartlett et al., 2002, Pest Manag Sei 60: 309). Es ist ebenfalls bekannt, dass das Herbizid Glyphosat in niedriger Dosierung das Wachstum einiger Pflanzenarten stimuliert (Cedergreen, Env. Pollution 2008, 156, 1099). Desweiteren wurden Effekte von Wachstumsregulatoren auf die Stresstoleranz von Kulturpflanzen beschrieben (Morrison and Andrews, 1992, J Plant Growth Regul 1 1 : 1 13-1 17, RD-259027). Bei osmotischem Stress ist eine Schutzwirkung durch Abscisic acid derivatives (Schading and Wei, WO200028055, Abrams and Gusta, US 5201931, Churchill et al., 1998, Plant Growth Regul 25: 35-45) or azibenzolar-S-methyl. Even with the use of fungicides, in particular from the group of strobilurins or succinate dehydrogenase inhibitors similar effects are observed, which are often associated with an increase in yield (Draber et al., DE-3534948, Bartlett et al., 2002, Pest Management, 60: 309). It is also known that the low dose herbicide glyphosate stimulates the growth of some plant species (Cedergreen, Env. Pollution 2008, 156, 1099). Furthermore, effects of growth regulators on the stress tolerance of crop plants have been described (Morrison and Andrews, 1992, J Plant Growth Regul 1 1: 1 13-1 17, RD-259027). When osmotic stress is a protective effect through
Applikation von Osmolyten wie z.B. Glycinbetain oder deren biochemischen Vorstufen, z.B. Cholin-Derivate beobachtet worden (Chen et al., 2000, Plant Cell Environ 23: 609- 618, Bergmann et al., DE-4103253). Auch die Wirkung von Antioxidantien wie z.B.Application of osmolytes, e.g. Glycine betaine or its biochemical precursors, e.g. Choline derivatives have been observed (Chen et al., 2000, Plant Cell Environ 23: 609-618, Bergmann et al., DE-4103253). Also, the effect of antioxidants, e.g.
Naphtole und Xanthine zur Erhöhung der abiotischen Stresstoleranz in Pflanzen wurde bereits beschrieben (Bergmann et al., DD-277832, Bergmann et al., DD-277835). Die molekularen Ursachen der Anti-Stress-Wirkung dieser Substanzen sind jedoch weitgehend unbekannt. Naphtols and xanthines for increasing the abiotic stress tolerance in plants have already been described (Bergmann et al., DD-277832, Bergmann et al., DD-277835). However, the molecular causes of the anti-stress effects of these substances are largely unknown.
Es ist weiter bekannt, dass die Toleranz von Pflanzen gegenüber abiotischem Stress durch eine Modifikation der Aktivität von endogenen Poly-ADP-ribose Polymerasen (PARP) oder Poly-(ADP-ribose) glycohydrolasen (PARG) erhöht werden kann (de Block et al., The Plant Journal, 2005, 41 , 95; Levine et al., FEBS Lett. 1998, 440, 1 ; WO0004173; WO04090140). It is further known that the tolerance of plants to abiotic stress can be increased by a modification of the activity of endogenous poly-ADP-ribose polymerases (PARP) or poly (ADP-ribose) glycohydrolases (PARG) (de Block et al. , The Plant Journal, 2005, 41, 95; Levine et al., FEBS Lett. 1998, 440, 1, WO0004173, WO04090140).
Somit ist bekannt, dass Pflanzen über mehrere endogene Reaktionsmechanismen verfügen, die eine wirksame Abwehr gegenüber verschiedensten Schadorganismen und/oder natürlichem abiotischen Stress bewirken können. Thus, it is known that plants have a number of endogenous reaction mechanisms that can effect effective defense against a variety of harmful organisms and / or natural abiotic stress.
Da sich aber die ökologischen und ökonomischen Anforderungen an moderne But since the ecological and economic requirements of modern
Pflanzenbehandlungsmittel laufend erhöhen, beispielsweise was Toxizität, Selektivität, Aufwandmenge, Rückstandsbildung und günstige Herstellbarkeit angeht, besteht die ständige Aufgabe, neue Pflanzenbehandlungsmittel zu entwickeln, die zumindest in Teilbereichen Vorteile gegenüber den bekannten aufweisen. Constantly increase plant treatment, for example, as regards toxicity, selectivity, application rate, residue formation and cheap manufacturability, there is the constant task of developing new plant treatment agents that have advantages over the known at least in some areas.
Daher bestand die Aufgabe der vorliegenden Erfindung darin, weitere Verbindungen bereitzustellen, die die Toleranz gegenüber natürlichem, d.h. nicht durch Pestizide, bevorzugt nicht durch Herbizide ausgelöstem abiotischen Stress in Pflanzen erhöhen. Gegenstand der vorliegenden Erfindung ist demnach die Verwendung substituierter Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze Therefore, the object of the present invention was to provide further compounds that increase the tolerance to natural, ie not by pesticides, preferably not triggered by herbicides abiotic stress in plants. The present invention accordingly provides for the use of substituted pyridone carboxamides of the general formula (I) or salts thereof
zur Toleranzerhöhung gegenüber abiotischem Stress in Pflanzen, wobei R1 (Ci-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (Ci-C6)-Haloalkyl, (C2-C6)- to increase tolerance to abiotic stress in plants, wherein R 1 is (Ci-C 6) -alkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) -alkynyl, (Ci-C 6) -haloalkyl, ( C 2 -C 6 ) -
Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (Cs-CeJ-CycloalkyKCi-Ce)- alkyl, (Ci-C6)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy, (Ci-C6)-Haloalkoxy, (C2-C6)-Haloalkenyloxy, (C2-C6)-Haloalkinyloxy, Cyano, Halogen oder Haloalkenyl, (C2-C6) haloalkynyl, (C3-C6) cycloalkyl, (Cs-CeJ-CycloalkyKCi-Ce) - alkyl, (Ci-C 6) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6 ) -alkynyloxy, (C 1 -C 6 ) -haloalkoxy, (C 2 -C 6 ) -haloalkenyloxy, (C 2 -C 6 ) -haloalkynyloxy, cyano, halogen or
gegebenenfalls ein oder mehrfach substituiertes Phenyl bedeutet,  optionally mono- or polysubstituted phenyl,
R2 (Ci-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (Ci-C6)-Haloalkyl, (C2-C6)-R 2 is (Ci-C 6) -alkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) -alkynyl, (Ci-C 6) -haloalkyl, (C 2 -C 6) -
Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (Cs-CeJ-CycloalkyKCi-Ce)- alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy, (Ci-C6)-Haloalkoxy, (C2-C6)-Haloalkenyloxy, (C2-C6)-Haloalkinyloxy, Cyano, Halogen oder Haloalkenyl, (C2-C6) haloalkynyl, (C3-C6) cycloalkyl, (Cs-CeJ-CycloalkyKCi-Ce) - alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, ( C 2 -C 6 -alkynyloxy, (C 1 -C 6 ) -haloalkoxy, (C 2 -C 6 ) -haloalkenyloxy, (C 2 -C 6 ) -haloalkynyloxy, cyano, halogen or
gegebenenfalls ein oder mehrfach substituiertes Phenyl bedeutet,  optionally mono- or polysubstituted phenyl,
R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)- Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )- alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]- carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, R 3 and R 4 independently of one another are hydrogen, (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or halogen by one or more radicals , Hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, and di [(C 1 -C 4) -alkyl] -amino , Hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted , Heteroaryl which is unsubstituted or substituted or substituted heterocyclyl which is unsubstituted or substituted,
oder (C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten or (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) -cycloalkyl, which on one side of the ring with a 4 to 6-membered saturated or unsaturated
carbocyclischen Ring kondensiert ist, oder (C4-C6)-Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )- Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci- C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, carbocyclic ring, or (C 4 -C 6) -cycloalkenyl fused on one side of the ring with a 4- to 6-membered saturated or unsaturated carbocyclic ring, each of the latter 4 radicals being unsubstituted or substituted by one or more radicals the group halogen, hydroxy, cyano, (Ci-C) -alkyl, (Ci-C) -haloalkyl, (Ci-C) -alkoxy, (Ci-C) - haloalkoxy, (Ci-C) -alkylthio, (Ci -C) -alkylamino, di [(C 1 -C 4 ) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) Cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, or
R3 Wasserstoff oder (Ci-Ce)-Alkyl bedeutet und R 3 is hydrogen or (C 1 -C 6) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]- carbonyl und (Ci-C4)-Alkylthio substituiert ist, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or R 3 and R 4 together with the directly bonded N atom form a four- to eight-membered heterocyclic ring which, in addition to the N atom, may also contain further hetero ring atoms, preferably up to two further hetero ring atoms from the group consisting of N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, (Ci-C 4) alkyl, (Ci-C4) - haloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) - Haloalkoxy, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten, wobei -N = CR 5 -NR 6 R 7 , where
R5 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 5 is hydrogen or (C 1 -C 6) -alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-Ce)-Alkyl bedeuten, oder R6, R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6 ) -alkyl, or R 6 ,
R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bis siebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl . R 7 together with the directly attached N atom form a five- to seven-membered, preferably saturated heterocyclic ring, such as, for example, piperidinyl, pyrrolidinyl or morpholinyl.
Im Folgenden werden die Verbindungen der Formel (I) und ihre Salze in einigen Fällen auch kurz als erfindungsgemäß verwendete oder erfindungsgemäße„Verbindungen (I)" bezeichnet. In the following, the compounds of the formula (I) and their salts are in some cases also referred to briefly as "compounds (I)" used according to the invention or according to the invention.
Die Verbindungen der Formel (I) umfassen auch Tautomere, welche durch Wasserstoffverschiebung gebildet werden können und welche strukturell formal nicht unter die Formel (I) fallen. Gleichwohl gelten diese Tautomere als von der Definition der erfindergemäßen Verbindungen der Formel (I) umfasst. Insbesondere umfasst sind von der Definition der Verbindungen der Formel (I) die tautomeren Strukturen der The compounds of the formula (I) also include tautomers which can be formed by hydrogen displacement and which structurally formally do not fall under the formula (I). Nevertheless, these tautomers are considered to be encompassed by the definition of the compounds of the formula (I) according to the invention. In particular, the definition of the compounds of formula (I) includes the tautomeric structures of
Formel (la) (2-Hydroxy-pyridin-3-carboxamide) oder deren Salze,  Formula (Ia) (2-hydroxy-pyridine-3-carboxamide) or its salts,
worin wherein
R1, R2, R3 und R4 wie in Formel (I) definiert sind. Bevorzugt ist die erfindungsgemäße Verwendung von Verbindungen der allgemeinen Formel (I) oder deren Salze, worin R 1 , R 2 , R 3 and R 4 are as defined in formula (I). Preference is given to the use according to the invention of compounds of the general formula (I) or salts thereof, in which
R1 (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (Ci-Ce)-Alkoxy oder (Ci-C6)- Haloalkoxy bedeutet, R 1 is (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, (C 3 -C 6 ) -cycloalkyl, (C 1 -C 6 ) -alkoxy or (C 1 -C 6 ) -haloalkoxy,
R2 (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (Ci-C6)-Alkoxy, (Ci-C6)- Haloalkoxy oder Halogen bedeutet und R 2 is (Ci-C 6) -alkyl, (Ci-C 6) -haloalkyl, (C 3 -C 6) cycloalkyl, (Ci-C 6) alkoxy, (Ci-C6) - haloalkoxy or halogen and
R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)- Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )- alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]- carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder R 3 and R 4 independently of one another are hydrogen, (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or halogen by one or more radicals , Hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, and di [(C 1 -C 4) -alkyl] -amino , Hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted Heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted, or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) -cycloalkyl, which on one side of the ring with a 4 to 6-membered saturated or unsaturated
carbocyclischen Ring kondensiert ist, oder (C4-C6)-Cycloalkenyl, das an einercondensed carbocyclic ring, or (C 4 -C 6) cycloalkenyl attached to a
Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )- Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-Condensed side of the ring with a 4- to 6-membered saturated or unsaturated carbocyclic ring, each of the latter 4 radicals unsubstituted or by one or more radicals selected from the group halogen, hydroxy, cyano, (Ci-C) alkyl, (Ci -C) -haloalkyl, (Ci-C) -alkoxy, (Ci-C) - haloalkoxy, (Ci-C) -alkylthio, (Ci-C) -alkylamino, di [(Ci-C) -alkyl] -amino ,
C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, oder C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted is or substituted heterocyclyl which is unsubstituted or substituted, or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, or
R3 Wasserstoff oder (Ci-Ce)-Alkyl bedeutet und R 3 is hydrogen or (C 1 -C 6) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]- carbonyl und (Ci-C4)-Alkylthio substituiert ist oder form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( Ci-C 4) alkyl, (Ci-C4) - haloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) -haloalkoxy, hydroxycarbonyl, [(Ci-C 4) alkoxy] - carbonyl and (Ci-C 4 ) -Alkylthio is substituted or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten und wobei R5 für Wasserstoff oder (Ci-C6)-Alkylsteht und -N = CR 5 -NR 6 R 7 and wherein R 5 is hydrogen or (C 1 -C 6 ) -alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-C6)-Alkyl bedeuten, oder R6 und R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bissiebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl . R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6 ) -alkyl, or R 6 and R 7 together with the directly bonded N atom form a five-bissile-membered, preferably saturated heterocyclic ring, for example piperidinyl, pyrrolidinyl or morpholinyl ,
Besonders bevorzugt ist die erfindungsgemäße Verwendung von Verbindungen der allgemeinen Formel (I) oder deren Salze, worin Particular preference is given to the use according to the invention of compounds of the general formula (I) or salts thereof, in which
R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R2 (Ci-Ce)-Alkyl oder Halogen bedeutet, R 1 is (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl, R 2 is (C 1 -C 6 ) -alkyl or halogen,
R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)- Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )- alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]- carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, R 3 and R 4 independently of one another are hydrogen, (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or halogen by one or more radicals , Hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, and di [(C 1 -C 4) -alkyl] -amino , Hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted , Heteroaryl which is unsubstituted or substituted or substituted heterocyclyl which is unsubstituted or substituted,
oder  or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) -cycloalkyl, which on one side of the ring with a 4 to 6-membered saturated or unsaturated
carbocyclischen Ring kondensiert ist, oder (C4-C6)-Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )- Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci- C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, carbocyclic ring, or (C 4 -C 6) -cycloalkenyl fused on one side of the ring with a 4- to 6-membered saturated or unsaturated carbocyclic ring, each of the latter 4 radicals being unsubstituted or substituted by one or more radicals the group halogen, hydroxy, cyano, (Ci-C) -alkyl, (Ci-C) -haloalkyl, (Ci-C) -alkoxy, (Ci-C) - haloalkoxy, (Ci-C) -alkylthio, (Ci -C) -alkylamino, di [(Ci-C) -alkyl] -amino, [(CI) C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted is or substituted heterocyclyl which is unsubstituted or substituted,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder für Wasserstoff oder (Ci-Ce)-Alkyl steht und  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or denote hydrogen or (C 1 -C 6) -alkyl and
(Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy, or (Ci-C 6 ) -alkyl-SO 2 , or R 3 and R 4 together with the directly bonded N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)-form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( C 1 -C 4 -alkyl, (C 1 -C 4 ) -
Haloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]- carbonyl und (Ci-C4)-Alkylthio substituiert ist, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe Haloalkyl, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio, or R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten und wobei R5 für Wasserstoff oder (Ci-C6)-Alkyl steht und -N = CR 5 -NR 6 R 7 and wherein R 5 is hydrogen or (Ci-C 6 ) alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-Ce)-Alkyl bedeuten, oder R6, R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6 ) -alkyl, or R 6 ,
R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bis siebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl . R 7 together with the directly attached N atom form a five- to seven-membered, preferably saturated heterocyclic ring, such as, for example, piperidinyl, pyrrolidinyl or morpholinyl.
Ganz besonders bevorzugt ist die erfindungsgemäße Verwendung von Verbindungen der allgemeinen Formel (I) oder deren Salze, worin Very particular preference is given to the use according to the invention of compounds of the general formula (I) or salts thereof, in which
R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R2 (Ci-Ce)-Alkyl oder Halogen bedeutet, R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeuten, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci- C4)-alkyl]-amino, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3- C6)-Cycloalky, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, R 1 is (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl, R 2 is (C 1 -C 6 ) -alkyl or halogen, R 3 and R 4 are each independently hydrogen, (C 1 -C 16) -alkyl , (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals selected from the group consisting of halogen, hydroxy, cyano, (C 1 -C 4) -alkoxy, (Ci -C) haloalkoxy, (Ci-C) alkylthio, (Ci-C) alkylamino, di [(CI-C 4) -alkyl] amino, [(Ci-C 4) -alkoxy] carbonyl, [ (C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalky, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or substituted heterocyclyl which is unsubstituted or substituted,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, or
R3 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 3 is hydrogen or (Ci-Ce) alkyl and
R4 (Ci-C6)-Alkyl, (Ci-C6)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet oder R 4 is (Ci-C 6) -alkyl, (Ci-C 6) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy, or ( Ci-C 6 ) -alkyl-SO 2 means or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere form eight-membered heterocyclic ring, which in addition to the N atom also further
Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl und (Ci- C )-Alkylthio substituiert ist., Hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S may contain and unsubstituted or by one or more radicals from the group halogen, cyano, nitro, (Ci-C 4 ) alkyl, (Ci-C 4 ) - Haloalkyl, (Ci-C) -alkoxy, (Ci-C) -haloalkoxy, [(Ci-C) -alkoxy] -carbonyl and (Ci-C) -alkylthio is substituted.,
Im Wesentlichen sind die zuvor genannten substituierten Pyridoncarboxamide der allgemeinen Formel (I) ebenfalls noch nicht im Stand der Technik bekannt. In essence, the abovementioned substituted pyridone carboxamides of the general formula (I) are likewise not yet known in the prior art.
Somit gelten als weiterer Teil der Erfindung substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, Thus, as a further part of the invention, substituted pyridone carboxamides of the general formula (I) or salts thereof,
worin (Ci-Ce)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, (Ci-C6)-Alkyl oder Halogen bedeutet, wherein (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl, (C 1 -C 6 ) -alkyl or halogen,
Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C4)-Alkylthio, (Ci-C4)-Alkylamino, Di[(Ci-C4)-alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeutet, Hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxyl, Cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, di [(C 1 -C 4 ) -alkyl] - amino, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted is substituted,
oder or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) -cycloalkyl, which on one side of the ring with a 4 to 6-membered saturated or unsaturated
carbocyclischen Ring kondensiert ist, oder (C4-C6)-Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist bedeutet, carbocyclic ring is condensed, or (C 4 -C 6) -cycloalkenyl which is fused on one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring,
oder or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet und  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted, and
(Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6) -alkynyl, where each of the
letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Alkylthio, (Ci-C4)-Alkylamino, Di[(Ci-C4)-alkyl]-amino, Hydroxycarbonyl, [(Ci- C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeutet, the latter 3 radicals unsubstituted or by one or more radicals from the group halogen, hydroxy, cyano, (Ci-C 4 ) alkoxy, (Ci-C 4 ) -haloalkoxy, (Ci-C 4 ) alkylthio, (Ci-C 4 ) -alkylamino, di [(C 1 -C 4 ) -alkyl] -amino, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 4 ) -alkyl, C 6) cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted,
oder (C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten or (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) -cycloalkyl, which on one side of the ring with a 4 to 6-membered saturated or unsaturated
carbocyclischen Ring kondensiert ist, oder (C4-C6)-Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist bedeutet, carbocyclic ring is condensed, or (C 4 -C 6) -cycloalkenyl which is fused on one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet oder  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted, or
R3 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 3 is hydrogen or (C 1 -C 6) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]- carbonyl und (Ci-C4)-Alkylthio bedeuten, oder form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( Ci-C 4) alkyl, (Ci-C4) - haloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) -haloalkoxy, hydroxycarbonyl, [(Ci-C 4) alkoxy] - carbonyl and (C 1 -C 4 ) -alkylthio, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten, Mean -N = CR 5 -NR 6 R 7 ,
R5 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 5 is hydrogen or (C 1 -C 6) -alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-Ce)-Alkyl bedeuten, oder R6 und R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bis siebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl bedeuten, ausgenommen Verbindungen der allgemeinen Formel (I), in denen R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6 ) -alkyl, or R 6 and R 7 together with the directly bonded N atom form a five- to seven-membered, preferably saturated heterocyclic ring, such as piperidinyl, pyrrolidinyl or Morpholinyl, except compounds of general formula (I), in which
(a) R1 und R2 für Methyl, R3 für Wasserstoff und R4 für Benzyl steht, oder (a) R 1 and R 2 are methyl, R 3 is hydrogen and R 4 is benzyl, or
(b) wenn R1 für (Ci-C6)-Haloalkyl und R2 gleichzeitig für Halogen steht. (b) when R 1 is (C 1 -C 6) haloalkyl and R 2 is simultaneously halogen.
Ganz besonders bevorzugt sind substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, worin Very particular preference is given to substituted pyridone carboxamides of the general formula (I) or salts thereof, in which
R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R2 Methyl bedeutet, R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet R 1 is (Ci-C 6) -alkyl or (Ci-C 6) -haloalkyl, R 2 is methyl, R 3 is hydrogen, (Ci-C 6) -alkyl, (C 2 -C 6) alkenyl or ( C 2 -C 6) alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (Ci -C) -alkylthio, (C 1 -C 4) -alkylamino, di [(C 1 -C 4) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] - carbonyl, (C3-C6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or substituted heterocyclyl which is unsubstituted or substituted
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, und Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, and
R4 (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der R 4 is (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6) -alkynyl, wherein each of the
letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Al kylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet last 3 radicals being unsubstituted or substituted by one or more radicals from the group halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (CI-C 4) -alkyl alkylthio, (Ci- C) -alkylamino, di [(C 1 -C 4) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl , Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted, or heterocyclyl which is unsubstituted or substituted
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, oder  Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, or
R3 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 3 is hydrogen or (C 1 -C 6) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann, und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio substituiert ist, ausgenommen Verbindungen der allgemeinen Formel (I), in denen R1 und R2 für Methyl, R3 für Wasserstoff und R4 für Benzyl steht. Ebenfalls ganz besonders bevorzugt sind substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, worin form eight-membered heterocyclic ring, which in addition to the N atom also further Hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S may contain, and unsubstituted or by one or more radicals from the group halogen, cyano, nitro, (Ci-C 4 ) alkyl, (Ci-C 4) - haloalkyl, (Ci-C) alkoxy, (Ci-C) haloalkoxy, [(Ci-C) alkoxy] carbonyl and (Ci- C4) alkylthio is substituted, other than compounds of general formula ( I) in which R 1 and R 2 are methyl, R 3 is hydrogen and R 4 is benzyl. Also very particularly preferred are substituted Pyridoncarboxamide the general formula (I) or salts thereof, wherein
R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R2 Ethyl bedeutet, R 1 is (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl, R 2 is ethyl,
R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, R 3 is hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6 ) -alkynyl,
wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci- C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino,wherein each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 6) -haloalkoxy, (C 1 -C 4 ) -alkylthio, ( C) -alkylamino, di [(Ci-C) -alkyl] -amino,
[(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or Heterocyclyl, which is unsubstituted or substituted, means
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, und  Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, and
(Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Al kylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxyl, cyano, C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, di [(C 1 -C 4) -alkyl] -amino, [(ci] C) -alkoxy] -carbonyl, [(Ci-C 4 ) -haloalkoxy] -carbonyl, (C3-C6) -cycloalkyl, phenyl, the is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or substituted heterocyclyl which is unsubstituted or substituted
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, oder R3 für Wasserstoff oder (Ci-C6)-Alkyl steht und Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or R 3 is hydrogen or (C 1 -C 6 ) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or R 3 and R 4 together with the directly bonded N atom four - to
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl und (Ci-form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C -haloalkoxy, C 1 -C 4 -alkoxy-carbonyl and
C4)-Alkylthio subtstituiert ist. C 4 ) alkylthio is subtituted.
Ebenfalls ganz besonders bevorzugt sind substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, worin R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R2 n-Propyl bedeutet, Also very particularly preferred are substituted Pyridoncarboxamide the general formula (I) or salts thereof, wherein R 1 is (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl, R 2 is n-propyl,
R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, R 3 is hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6) -alkenyl or (C 2 -C 6) -alkynyl,
wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci- C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocydyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet oder wherein each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 6) -haloalkoxy, (C 1 -C 4 ) -alkylthio, ( C) -alkylamino, di [(C 1 -C 4 ) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) - Cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted, or heterocyclic which is unsubstituted or substituted, or denotes
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocydyl, das unsubstituiert oder substituiert ist, bedeutet, und  Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclic which is unsubstituted or substituted, and
R4 (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Al kylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocydyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet R 4 is (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6 ) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (CI-C 4) -alkyl alkylthio, (Ci-C) alkylamino, di [(Ci-C) alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclic which is unsubstituted or substituted
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocydyl, das unsubstituiert oder substituiert ist, bedeutet, oder R3 für Wasserstoff oder (Ci-C6)-Alkyl steht und R4 (Ci-C6)-Alkyl, (Ci-C6)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclic which is unsubstituted or substituted, or R 3 is hydrogen or (Ci-C 6) -alkyl and R 4 is (Ci-C 6) -alkyl, (Ci-C 6) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6 ) -Alkinyloxy or (C 2 -C 6 ) - haloalkoxy or (Ci-C 6 ) -alkyl-SO 2 , or R 3 and R 4 together with the directly attached N-atom of an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)-form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( C 1 -C 4 -alkyl, (C 1 -C 4 ) -
Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio bedeuten substituiert ist. Haloalkyl, (Ci-C) alkoxy, (Ci-C) haloalkoxy, [(Ci-C) alkoxy] carbonyl and (Ci- C 4) alkylthio substituted mean.
Ebenfalls ganz besonders bevorzugt sind substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, worin Also very particularly preferred are substituted Pyridoncarboxamide the general formula (I) or salts thereof, wherein
R1 (Ci-C6)-Alkyl bedeutet, R 1 is (C 1 -C 6 ) -alkyl,
R2 Chlor bedeutet, R 2 is chlorine,
R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Cie)-Alkinyl bedeutet, R 3 is hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -Cie) -alkynyl,
wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci- C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet wherein each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 6) -haloalkoxy, (C 1 -C 4 ) -alkylthio, ( C) -alkylamino, di [(Ci-C) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or Heterocyclyl, which is unsubstituted or substituted, means
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, und Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, and
R4 (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Al kylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet R 4 is (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6 ) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (CI-C 4) -alkyl alkylthio, (Ci-C) alkylamino, di [(Ci-C) alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, oder für Wasserstoff oder (Ci-Ce)-Alkyl steht und R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or is hydrogen or (C 1 -C 6 ) -alkyl and R 4 is (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxy, (C 2 -C 6 ) -alkenyloxy, (C 2 -C 6 ) -alkynyloxy or (C 2 -C 6 ) -haloalkoxy or (C 1 -C 6 ) -alkyl-SO 2 , or R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio substutiert ist., Ebenfalls ganz besonders bevorzugt sind substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, worin form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -haloalkyl, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkyl ) Alkylthio is substuted., Also very particularly preferred are substituted Pyridoncarboxamide the general formula (I) or salts thereof, wherein
R1 (Ci-C6)-Alkyl bedeutet, R2 Brom bedeutet, R 1 is (C 1 -C 6 ) -alkyl, R 2 is bromine,
R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, R 3 is hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6 ) -alkynyl,
wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci- C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino,wherein each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 6) -haloalkoxy, (C 1 -C 4 ) -alkylthio, ( C) -alkylamino, di [(Ci-C) -alkyl] -amino,
[(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or Heterocyclyl, which is unsubstituted or substituted, means
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, und R4 (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bedeutet, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Al kylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, and R 4 is (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6) -alkynyl, where each of the last-named 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy , cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (CI-C 4) -alkyl alkylthio, (Ci-C) alkylamino, di [(Ci-C) alkyl] - amino, [(C 1 -C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, oder für Wasserstoff oder (Ci-Ce)-Alkyl steht und  Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or is hydrogen or (C 1 -C 6) -alkyl and
(Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6) Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) haloalkoxy, or (Ci-C 6 ) -Alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or R 3 and R 4 together with the directly bonded N atom form a four - to
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( C 1 -C 4 -alkyl, (C 1 -C 4 ) - Haloalkyl, (Ci-C) alkoxy, (Ci-C) haloalkoxy, [(Ci-C) alkoxy] carbonyl
C4)-Alkylthio substitiert ist., C 4 ) -alkylthio is substituted.,
Ebenfalls ganz besonders bevorzugt sind substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, worin Also very particularly preferred are substituted Pyridoncarboxamide the general formula (I) or salts thereof, wherein
R1 (Ci-C6)-Alkyl bedeutet, R2 lod bedeutet, R 1 is (C 1 -C 6 ) -alkyl, R 2 is iodine,
R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bdeutet, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)- Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-R 3 denotes hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6 ) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or by one or more radicals from the group Halogen, hydroxy, cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, di [(C 1 -C 4) -alkyl] amino, [(ci
C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocydyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted, or heterocyclic which is unsubstituted or substituted, means
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocydyl, das unsubstituiert oder substituiert ist, bedeutet, und  Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and heterocyclic which is unsubstituted or substituted, and
R4 (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl bdeutet, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci- C4)-Al kylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocydyl, das unsubstituiert oder substituiert ist, substituiert ist, bedeutet R 4 is (C 1 -C 6 ) -alkyl, C 2 -C 6 -alkenyl or C 2 -C 6 -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (CI-C 4) -alkyl alkylthio, (Ci-C) alkylamino, di [(Ci-C) alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclic which is unsubstituted or substituted
oder Phenyl, das unsubstituiert oder substituiert ist, Hetaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet, oder für Wasserstoff oder (Ci-Ce)-Alkyl steht und or Phenyl which is unsubstituted or substituted, hetaryl which is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or is hydrogen or (C 1 -C 6) -alkyl and
(Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)- Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten oder (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) - haloalkoxy, or (Ci-C 6 ) -alkyl-SO 2 , or R 3 and R 4 together with the directly bonded N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)-form an eight-membered heterocyclic ring which may contain, in addition to the N atom, also further hetero ring atoms, preferably up to two further hetero ring atoms from the group N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, ( C 1 -C 4 -alkyl, (C 1 -C 4 ) -
Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, [(Ci-C )-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio substitiert ist., Haloalkyl, (C 1 -C 4) -alkoxy, (C 1 -C 4) -haloalkoxy, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio.
Somit gilt als weiterer Gegenstand der Erfindung auch eine Sprühlösung zur Thus, a further subject of the invention is also a spray solution for
Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge einer oder mehrer der zuvor genannten substituierten Pyridoncarboxamide mit Ausnahme der Verbindung der allgemeinen Formel (I), in der (a) gleichzeitig R1 und R2 für Methyl u R3 für Wasserstoff und R4 für Benzyl stehen und (b) Verbindungen der allgemeinen Formel (I), in denen gleichzeitig R1 für (Ci-C6)-Haloalkyl und R2 für Halogen stehen. Treatment of plants containing an amount of one or more of the abovementioned substituted pyridone carboxamides effective to increase the resistance of plants to abiotic stress factors, with the exception of the compound of general formula (I) wherein (a) simultaneously R 1 and R 2 are methyl and the like R 3 is hydrogen and R 4 is benzyl and (b) compounds of the general formula (I) in which at the same time R 1 is (Ci-C6) -haloalkyl and R 2 is halogen.
Im Hinblick auf die erfindungsgemäßen Verbindungen werden die vorstehend und weiter unten verwendeten Bezeichnungen erläutert. Diese sind dem Fachmann geläufig und haben insbesondere die im Folgenden erläuterten Bedeutungen: With regard to the compounds according to the invention, the terms used above and below are explained. These are familiar to the person skilled in the art and in particular have the meanings explained below:
Die Bezeichnung "Halogen" bedeutet beispielsweise Fluor, Chlor, Brom oder lod. Wird die Bezeichnung für einen Rest verwendet, dann bedeutet "Halogen" The term "halogen" means, for example, fluorine, chlorine, bromine or iodine. If the term is used for a remainder, then "halogen" means
beispielsweise ein Fluor-, Chlor-, Brom- oder lodatom. for example, a fluorine, chlorine, bromine or iodine atom.
Alkyl bedeutet erfindungsgemäß einen geradkettigen oder verzweigten offen kettigen, gesättigten Kohlenwasserstoffrest, der gegebenenfalls ein- oder mehrfach substituiert ist. Bevorzugte Substituenten sind Halogenatome, Alkoxy-, Haloalkoxy-, Cyano-, Alkylthio, Haloalkylthio- oder Nitrogruppen, besonders bevorzugt sind Fluor, Chlor, Brom oder lod. Alkyl means according to the invention a straight-chain or branched open-chain, saturated hydrocarbon radical which is optionally mono- or polysubstituted. Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio or nitro groups, particular preference is given to fluorine, chlorine, bromine or iodine.
Fluoralkyl bedeutet einen geradkettigen oder verzweigten offen kettigen, gesättigten und durch Fluor substituierten Kohlenwasserstoffrest, wobei sich mindestens ein Fluoratom an einer der möglichen Positionen befindet. Fluoroalkyl means a straight-chain or branched open-chain, saturated and fluorine-substituted hydrocarbon radical, at least one fluorine atom being in one of the possible positions.
Perfluoralkyl bedeutet einen geradkettigen oder verzweigten offen kettigen, gesättigten und vollständig durch Fluor substituierten Kohlenwasserstoffrest wie z.B. CF3, CF2CF3, Perfluoroalkyl means a straight-chain or branched, open-chain, saturated and completely fluorine-substituted hydrocarbon radical, for example CF 3, CF 2 CF 3,
Teilfluoriertes Alkyl bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der einfach oder mehrfach durch Fluor substituiert ist, wobei sich die entsprechenden Fluoratome als Substituenten an einem oder mehreren Partially fluorinated alkyl means a straight-chain or branched, saturated hydrocarbon which is monosubstituted or polysubstituted by fluorine, the corresponding fluorine atoms being present as substituents on one or more
verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten different carbon atoms of the straight-chain or branched
Kohlenwasserstoffkette befinden können, wie z. B. CHFCH3, CH2CH2F, CH2CH2CF3, CHF2, CH2F, CHFCF2CF3 Hydrocarbon chain can be located, such as. B. CHFCH3, CH2CH2F, CH2CH2CF3, CHF 2, CH 2 F, CHFCF2CF3
Teilfluoriertes Haloalkyl bedeutet einen geradkettigen oder verzweigten, gesättigten Kohlenwasserstoff, der durch verschiedenene Halogenatomen mit mindestens einem Fluoratom substituiert ist, wobei alle anderen gegebenenfalls vorhandenen Halogenatome ausgewählt sind aus der Gruppe Fluor, Chlor, Brom oder lod. Die entsprechenden Halogenatome können sich dabei als Substituenten an einem oder mehreren verschiedenen Kohlenstoffatomen der geradkettigen oder verzweigten Kohlenwasserstoffkette befinden. Teilfluoriertes Haloalkyl schließt auch die Partially fluorinated haloalkyl means a straight-chain or branched, saturated hydrocarbon which is represented by various halogen atoms having at least one Fluorine atom is substituted, all other optional halogen atoms are selected from the group fluorine, chlorine, bromine or iodine. The corresponding halogen atoms may be present as substituents on one or more different carbon atoms of the straight-chain or branched hydrocarbon chain. Partially fluorinated haloalkyl also includes the
vollständige Substitution der geradkettigen oder verzweigten Kette durch Halogen unter Beteiligung von mindestens einem Fluoratom ein. complete substitution of the straight-chain or branched chain by halogen with the participation of at least one fluorine atom.
Haloalkyl, -alkenyl und -alkinyl bedeuten durch gleiche oder verschiedene Haloalkyl, alkenyl and alkynyl mean the same or different
Halogenatome, teilweise oder vollständig substituiertes Alkyl, Alkenyl bzw. Alkinyl, z.B. Monohaloalkyl (= Monohalogenalkyl) wie z. B. CH2CH2CI, CH2CH2Br, CHCICH3, CH2CI, CH2F; Halogen atoms, partially or fully substituted alkyl, alkenyl or alkynyl, for example monohaloalkyl (= monohaloalkyl) such. CH 2 CH 2 Cl, CH 2 CH 2 Br, CHCICH 3 , CH 2 Cl, CH 2 F;
Perhaloalkyl wie z. B. CCI3, CCIF2, CFCI2,CF2CCIF2, CF2CCIFCF3; Polyhaloalkyl wie z. B. CH2CHFCI, CF2CCIFH, CF2CBrFH, CH2CF3; Der Begriff Perhaloalkyl umfasst dabei auch den Begriff Perfluoralkyl, und der Begriff Polyhaloalkyl umfasst auch die Begriffe teilfluoriertes Alkyl und teilfluoriertes Haloalkyl. Perhaloalkyl such. CCI 3 , CCIF 2 , CFCI 2 , CF 2 CCIF 2 , CF 2 CCIFCF 3 ; Polyhaloalkyl such. CH 2 CHFCI, CF 2 CCIFH, CF 2 CBrFH, CH 2 CF 3 ; The term perhaloalkyl also encompasses the term perfluoroalkyl, and the term polyhaloalkyl also encompasses the terms partially fluorinated alkyl and partially fluorinated haloalkyl.
Haloalkoxy ist z.B. OCF3, OCHF2, OCH2F, OCF2CF3, OCH2CF3 und OCH2CH2CI; Haloalkoxy is, for example, OCF 3 , OCHF 2 , OCH 2 F, OCF 2 CF 3 , OCH 2 CF 3 and OCH 2 CH 2 Cl;
Entsprechendes gilt für Haloalkenyl und andere durch Halogen substituierten Reste. The same applies to haloalkenyl and other halogen-substituted radicals.
Der Ausdruck "(Ci-C4)-Alkyl" bedeutet eine Kurzschreibweise für Alkyl mit einem bis vier Kohlenstoffatomen entsprechend der Bereichsangabe für C-Atome, d. h. umfasst die Reste Methyl, Ethyl, 1 -Propyl, 2-Propyl, 1 -Butyl, 2-Butyl, 2-Methylpropyl oder tert- Butyl. Allgemeine Alkylreste mit einem größeren angegebenen Bereich von C-Atomen, z. B. "(Ci-C6)-Alkyl", umfassen entsprechend auch gradkettige oder verzweigte The term "(C 1 -C 4 ) -alkyl" denotes a short notation for alkyl having one to four carbon atoms corresponding to the range given for C atoms, ie the radicals methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl or tert-butyl. General alkyl radicals having a larger specified range of carbon atoms, eg. As "(Ci-C6) -alkyl", accordingly also include straight-chain or branched
Alkylreste mit einer größeren Zahl von C-Atomen, d. h. gemäß Beispiel auch die Alkylreste mit 5 und 6 C-Atomen. Alkyl radicals having a larger number of C atoms, d. H. according to example, the alkyl radicals with 5 and 6 carbon atoms.
Wenn nicht speziell angegeben, sind bei den Kohlenwasserstoffresten wie Alkyl-, Alkenyl- und Alkinylresten, auch in zusammengesetzten Resten, die niederen Unless specifically stated, the hydrocarbon radicals such as alkyl, alkenyl and alkynyl radicals, even in assembled radicals, are lower
Kohlenstoffgerüste, z.B. mit 1 bis 6 C-Atomen bzw. bei ungesättigten Gruppen mit 2 bis 6 C-Atomen, bevorzugt. Alkylreste, auch in den zusammengesetzten Resten wie Alkoxy, Haloalkyl usw., bedeuten z.B. Methyl, Ethyl, n- oder i-Propyl, n-, i-, t- oder 2-Butyl, Pentyle, Hexyle, wie n-Hexyl, i-Hexyl und 1 ,3-Dimethylbutyl, Heptyle, wie n-Heptyl, 1 -Methylhexyl und 1 ,4-Dimethylpentyl; Alkenyl- und Alkinylreste haben die Bedeutung der den Alkylresten entsprechenden möglichen ungesättigten Reste, wobei mindestens eine Doppelbindung bzw. Dreifachbindung enthalten ist. Bevorzugt sind Reste mit einer Doppelbindung bzw. Dreifachbindung. Carbon skeletons, for example having 1 to 6 carbon atoms or in unsaturated groups having 2 to 6 carbon atoms, are preferred. Alkyl radicals, including in the assembled radicals such as alkoxy, haloalkyl, etc., mean, for example, methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls, such as n-hexyl, i Hexyl and 1, 3-dimethylbutyl, heptyls, such as n-heptyl, 1-methylhexyl and 1, 4-dimethylpentyl; Alkenyl and alkynyl radicals have the meaning of the possible unsaturated radicals corresponding to the alkyl radicals, wherein at least one double bond or triple bond is contained. Preference is given to radicals having a double bond or triple bond.
Alkenyl schließt insbesondere auch geradkettige oder verzweigte offenkettige Alkenyl in particular also includes straight-chain or branched open-chain
Kohlenwasserstoffreste mit mehr als einer Doppelbindung ein, wie 1 ,3-Butadienyl und 1 ,4-Pentadienyl, aber auch Allenyl- oder Kumulenyl-reste mit einer bzw. mehreren kumulierten Doppelbindungen, wie beispielsweise Allenyl (1 ,2-Propadienyl), 1 ,2- Butadienyl und 1 ,2,3-Pentatrienyl. Alkenyl bedeutet z.B. Vinyl, welches ggf. durch weitere Alkylreste substituiert sein kann, z.B. Prop-1 -en-1 -yl, But-1 -en-1 -yl, Allyl, 1 - Methyl-prop-2-en-1 -yl, 2-Methyl-prop-2-en-1 -yl, But-2-en-1 -yl, 1 -Methyl-but-3-en-1 -yl und 1 -Methyl-but-2-en-1 -yl, 2-Methylprop-1 -en-1 -yl, 1 -Methylprop-1 -en-1 -yl, Hydrocarbon radicals having more than one double bond, such as 1, 3-butadienyl and 1, 4-pentadienyl, but also allenyl or cumulene radicals having one or more cumulative double bonds, such as allenyl (1, 2-propadienyl), 1, 2-butadienyl and 1,2,3-pentatrienyl. Alkenyl means e.g. Vinyl, which may optionally be substituted by further alkyl radicals, e.g. Prop-1 -en-1-yl, but-1-en-1-yl, allyl, 1-methyl-prop-2-en-1-yl, 2-methyl-prop-2-en-1-yl, But-2-en-1-yl, 1-methylbut-3-en-1-yl and 1-methylbut-2-en-1-yl, 2-methylprop-1 -ene-1-yl, 1-methylprop-1-ene-1-yl,
1 - Methylprop-2-en-1 -yl, 2-Methyl-prop-2-en-1 -yl, But-2-en-1 -yl, But-3-en-1 -yl,  1-methylprop-2-en-1-yl, 2-methyl-prop-2-en-1-yl, but-2-en-1-yl, but-3-en-1-yl,
1 -Methyl-but-3-en-1 -yl oder 1 -Methyl-but-2-en-1 -yl, Pentenyl, 2-Methylpentenyl oder Hexenyl. 1-methyl-but-3-en-1-yl or 1-methyl-but-2-en-1-yl, pentenyl, 2-methylpentenyl or hexenyl.
Alkinyl schließt insbesondere auch geradkettige oder verzweigte offenkettige In particular, alkynyl also includes straight-chain or branched open-chain
Kohlenwasserstoffreste mit mehr als einer Dreifachbindung oder auch mit einer oder mehreren Dreifachbindungen und einer oder mehreren Doppelbindungen ein, wie beispielsweise 1 ,3-Butatrienyl bzw. 3-Penten-1 -in-1 -yl. (C2-C6)-Alkinyl bedeutet beispielsweise Ethinyl, Propargyl, 1 -Methyl-prop-2-in-1 -yl, 2-Butinyl, 2-Pentinyl oderHydrocarbon radicals having more than one triple bond or having one or more triple bonds and one or more double bonds, such as 1, 3-butatrienyl and 3-penten-1-yn-1-yl. For example, (C 2 -C 6) alkynyl means ethynyl, propargyl, 1-methyl-prop-2-yn-1-yl, 2-butynyl, 2-pentynyl or
2- Hexinyl, vorzugsweise Propargyl, But-2-in-1 -yl, But-3-in-1 -yl oder 2-hexynyl, preferably propargyl, but-2-yn-1-yl, but-3-yn-1-yl or
1 -Methyl-but-3-in-1 -yl. 1-methyl-but-3-yn-1-yl.
Der Begriff„Cycloalkyl" bedeutet ein carbocyclisches, gesättigtes Ringsystem mit vorzugsweise 3-8 Ring-C-Atomen, z.B. Cyclopropyl, Cyclobutyl, Cyclopentyl oder Cyclohexyl. The term "cycloalkyl" means a carbocyclic saturated ring system preferably having 3-8 ring C atoms, for example cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
Cycloalkenyl bedeutet ein carbocyclisches, nicht aromatisches, partiell ungesättigtes Ringsystem mit vorzugsweise 4-8 C-Atomen, z.B. 1 -Cyclobutenyl, 2-Cyclobutenyl, 1 - Cyclopentenyl, 2-Cyclopentenyl, 3-Cyclopentenyl, oder 1 -Cyclohexenyl, 2- Cyclohexenyl, 3-Cyclohexenyl, 1 ,3-Cyclohexadienyl oder 1 ,4-Cyclohexadienyl, Der Begriff„Aryl" bedeutet ein mono-, bi- oder polycyclisches aromatisches System mit vorzugsweise 6 bis 14, insbesondere 6 bis 10 Ring-C-Atomen, beispielsweise Phenyl, Naphthyl, Anthryl, Phenanthrenyl, und ähnliches, vorzugsweise gegebenenfalls einfach oder mehrfach mit einem Rest der Gruppe Halogen, Nitro, Hydroxy, Cyano, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylsulfoxy, (Ci-C )-Alkylsulfon, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]-carbonyl, [(Ci-C )-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, (C3-C6)- Cycloalkyl (Ci-C6)-alkyl, [(Ci-C )-Alkoxy]-carbonyl, [(Ci-C )-Alkoxy]-carbonyl-(Ci-C )- alkyl, Hydroxycarbonyl oder Hydroxycarbonyl-(Ci-C4)-alkyl substituiertesPhenyl. Cycloalkenyl means a carbocyclic, non-aromatic, partially unsaturated ring system preferably having 4-8 C atoms, for example 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl, 3-cyclopentenyl, or 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1, 3-cyclohexadienyl or 1, 4-cyclohexadienyl, The term "aryl" means a mono-, bi- or polycyclic aromatic system having preferably 6 to 14, in particular 6 to 10 ring C atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl, and the like, preferably optionally mono- or polysubstituted a radical from the group halogen, nitro, hydroxy, cyano, (C 1 -C 4) -alkyl, (C 1 -C 4) -haloalkyl, (C 1 -C 4) -alkoxy, (C 1 -C 4) -haloalkoxy, (C 1 -C 4) - Alkylthio, (Ci-C) alkylsulfoxy, (Ci-C) -alkylsulfone, (Ci-C) -alkylamino, di [(Ci-C) -alkyl] -amino, [(Ci-C) -alkoxy] -carbonyl , [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -cycloalkyl (C 1 -C 6 ) -alkyl, [(C 1 -C 4 ) -alkoxy] - carbonyl, [(C 1 -C 4) alkoxy] carbonyl (C 1 -C 4 ) alkyl, hydroxycarbonyl or hydroxycarbonyl (C 1 -C 4 ) alkyl substituted phenyl.
Vom Begriff„gegebenenfalls substituierte Aryl" sind auch mehrcyclische Systeme, wie Tetrahydronaphtyl, Indenyl, Indanyl, Fluorenyl, Biphenylyl, umfasst, wobei die The term "optionally substituted aryl" also includes polycyclic systems, such as tetrahydronaphthyl, indenyl, indanyl, fluorenyl, biphenylyl, wherein the
Bindungsstelle am aromatischen System ist. Binding site on the aromatic system is.
Von der Systematik her ist„Aryl" in der Regel auch von dem Begriff„gegebenenfalls substituiertes Phenyl" umfasst. As a rule, "aryl" is also encompassed by the term "optionally substituted phenyl".
Ein heterocyclischer Rest oder Ring (Heterocyclyl) kann gesättigt, ungesättigt oder heteroaromatisch und unsubstituiert oder beispielsweise mit einem Rest aus der Gruppe bestehend aus Halogen, Nitro, Hydroxy, Cyano, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylsulfoxy, (Ci-C )-Alkylsulfon, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl (C1-C6)- alkyl, [(Ci-C )-Alkoxy]-carbonyl, [(Ci-C )-Alkoxy]-carbonyl-(Ci-C )-alkyl, A heterocyclic radical or ring (heterocyclyl) can be saturated, unsaturated or heteroaromatic and unsubstituted or, for example, with a radical selected from the group consisting of halogen, nitro, hydroxy, cyano, (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) - Haloalkyl, (C 1 -C 4) -alkoxy, (C 1 -C 4) -haloalkoxy, (C 1 -C 4) -alkylthio, (C 1 -C 4) -alkylsulfoxy, (C 1 -C 4) -alkylsulfone, (C 1 -C 4) -alkylamino, Di [(C 1 -C 4) alkyl] amino, [(C 1 -C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl, (C 3 -C 6) ) -Cycloalkyl (C 1 -C 6) -alkyl, [(C 1 -C 4) -alkoxy] -carbonyl, [(C 1 -C 4) -alkoxy] -carbonyl (C 1 -C 4) -alkyl,
Hydroxycarbonyl oder Hydroxycarbonyl-(Ci-C4)-alkyl substituiert sein; er enthält vorzugsweise ein oder mehrere Heteroatome im Ring, vorzugsweise aus der Gruppe N, O und S; er ist ein aliphatischer Heterocyclylrest mit 3 bis 7 Ringatomen oder ein heteroaromatischer Rest mit 5 oder 6 Ringatomen und enthält 1 , 2 oder 3 Hydroxycarbonyl or hydroxycarbonyl- (C 1 -C 4 ) -alkyl; it preferably contains one or more heteroatoms in the ring, preferably from the group N, O and S; it is an aliphatic heterocyclyl radical having 3 to 7 ring atoms or a heteroaromatic radical having 5 or 6 ring atoms and contains 1, 2 or 3
Heteroatome. Der heterocyclische Rest kann z.B. ein heteroaromatischer Rest oder Ring (Heteroaryl) sein, wie z.B. ein mono-, bi- oder polycyclisches aromatisches System, in dem mindestens 1 Ring ein oder mehrere Heteroatome enthält, Hetero atoms. The heterocyclic radical may be e.g. a heteroaromatic radical or ring (heteroaryl), e.g. a mono-, bi- or polycyclic aromatic system in which at least one ring contains one or more heteroatoms,
beispielsweise Pyridyl, Pyrimidinyl, Pyridazinyl, Pyrazinyl, Triazinyl, Thienyl, Thiazolyl, Oxazolyl, Furyl, Pyrrolyl, Pyrazolyl und Imidazolyl, oder ist ein partiell oder vollständig hydrierter Rest wie Oxiranyl, Oxetanyl, Pyrrolidyl, Piperidyl, Piperazinyl, Dioxolanyl, Morpholinyl, Tetrahydrofuryl. Als Substituenten für einen substituierten For example, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, thienyl, thiazolyl, oxazolyl, furyl, pyrrolyl, pyrazolyl and imidazolyl, or is a partial or complete hydrogenated radical such as oxiranyl, oxetanyl, pyrrolidyl, piperidyl, piperazinyl, dioxolanyl, morpholinyl, tetrahydrofuryl. As substituents for a substituted
heterocyclischen Rest kommen die weiter unten genannten Substituenten in Frage, zusätzlich auch Oxo. Die Oxogruppe kann auch an den Heteroringatomen, die in verschiedenen Oxidationsstufen existieren können, z.B. bei N und S, auftreten. Heterocyclic radical are the substituents mentioned below in question, in addition also oxo. The oxo group may also be attached to the hetero ring atoms, which may exist in different oxidation states, e.g. at N and S, occur.
Alkoxy bedeutet ein über ein Sauerstoffatom gebundenen Alkylrest, Alkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkenylrest, Alkinyloxy bedeutet ein über ein Sauerstoffatom gebundenen Alkinylrest, Cycloalkyloxy bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkylrest und Cycloalkenyloxy bedeutet ein über ein Sauerstoffatom gebundenen Cycloalkenylrest. Alkoxy is an alkyl radical bonded via an oxygen atom, alkenyloxy is an alkynyl radical bonded via an oxygen atom, alkynyloxy is an alkynyl radical bound via an oxygen atom, cycloalkyloxy is a cycloalkyl radical bonded via an oxygen atom, and cycloalkenyloxy is a cycloalkenyl radical bonded via an oxygen atom.
Erfindungsgemäß steht "Alkylthio" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes S-Alkyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen, wie beispielsweise Methylthio, Ethylthio, n- Propylthio, Isopropylthio, n-Butylthio, Isobutylthio, sec-Butylthio und tert-Butylthio. Alkenylthio bedeutet ein über ein Schwefelatom gebundenen Alkenylrest, Alkinylthio bedeutet ein über ein Schwefelatom gebundenen Alkinylrest, Cycloalkylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkylrest und Cycloalkenylthio bedeutet ein über ein Schwefelatom gebundenen Cycloalkenylrest. According to the invention, "alkylthio" - alone or as part of a chemical group - represents straight-chain or branched S-alkyl, preferably having 1 to 8, or having 1 to 6 carbon atoms, such as, for example, methylthio, ethylthio, n-propylthio, isopropylthio, n- Butylthio, isobutylthio, sec-butylthio and tert-butylthio. Alkenylthio represents an alkenyl radical bonded via a sulfur atom, alkynylthio represents an alkynyl radical bonded via a sulfur atom, cycloalkylthio represents a cycloalkyl radical bonded via a sulfur atom, and cycloalkenylthio represents a cycloalkenyl radical bonded via a sulfur atom.
Erfindungsgemäß steht "AI kylsulfinyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes AI kylsulfinyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen wie beispielsweise Methylsulfinyl, Ethylsulfinyl, n-Propylsulfinyl, Isopropylsulfinyl, n-Butylsulfinyl, Isobutylsulfinyl, sec- Butylsulfinyl und tert-Butylsulfinyl. According to the invention "AI kylsulfinyl" - alone or as part of a chemical group - kylsulfinyl straight or branched Al, preferably having 1 to 8, or having 1 to 6 carbon atoms such as methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, isopropylsulfinyl, n-butylsulfinyl , Isobutylsulfinyl, sec-butylsulfinyl and tert-butylsulfinyl.
Erfindungsgemäß steht "AI kylsulfonyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für geradkettiges oder verzweigtes Alkylsulfonyl, vorzugsweise mit 1 bis 8, oder mit 1 bis 6 Kohlenstoffatomen wie beispielsweise Methylsulfonyl,According to the invention "Al kylsulfonyl" - alone or as part of a chemical group - is straight-chain or branched alkylsulfonyl, preferably having 1 to 8, or having 1 to 6 carbon atoms such as methylsulfonyl,
Ethylsulfonyl, n-Propylsulfonyl, Isopropylsulfonyl, n-Butylsulfonyl, Isobutylsulfonyl, sec- Butylsulfonyl und tert-Butylsulfonyl. Erfindungsgemäß steht "Cycloalkylsulfonyl" - in Alleinstellung oder als Bestandteil einer chemischen Gruppe - für gegebenenfalls substituiertes Cycloalkylsulfonyl, vorzugsweise mit 3 bis 6 Kohlenstoffatomen wie beispielsweise Cyclopropylsulfonyl, Cyclobutylsulfonyl, Cyclopentylsulfonyl oder Cyclohexylsulfonyl. Ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl and tert-butylsulfonyl. According to the invention "cycloalkylsulfonyl" - alone or as part of a chemical group - is optionally substituted Cycloalkylsulfonyl, preferably having 3 to 6 carbon atoms such as cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl or cyclohexylsulfonyl.
Erfindungsgemäß steht "Arylsulfonyl" für gegebenenfalls substituiertes Phenylsulfonyl oder gegebenenfalls substituiertes polycyclisches Arylsulfonyl, beispielsweise substituiert durch Halogen, Alkyl, Haloalkyl, Haloalkoxy oder Alkoxygruppen. Der Begriff„Sulfilimin" steht für eine Gruppe mit einer Stickstoff- Schwefeldoppelbindung, bei der Stickstoff und Schwefel weiter substituiert sind, das Stickstoffatom bevorzugt durch eine weiter substituierte Carbonylgruppe und der Schwefel bevorzugt durch zwei gleiche oder gemischte Alkyl, Aryl und According to the invention "arylsulfonyl" is optionally substituted phenylsulfonyl or optionally substituted polycyclic arylsulfonyl, for example substituted by halogen, alkyl, haloalkyl, haloalkoxy or alkoxy groups. The term "sulfilimine" means a group having a nitrogen-sulfur double bond in which nitrogen and sulfur are further substituted, the nitrogen atom preferably by a further substituted carbonyl group and the sulfur preferably by two identical or mixed alkyl, aryl and
Cycloalkylsubstituenten, beispielsweise in Form einer N-(Di-n-butyl-sulfanyliden), N- (Di-iso-propyl-sulfanyliden), N-(Di-n-propyl-sulfanyliden), N-(Di-n-pentyl-sulfanyliden), N-(Di-iso-butyl-sulfanyliden), N-(Cyclobutyl-iso-propyl-sulfanyliden), N-(n-Propyl-iso- propyl-sulfanyliden), N-(Cyclopropyl-iso-propyl-sulfanyliden) oder N-(lso-Butyl-iso- propyl-sulfanyliden) Einheit. Die Verbindungen der allgemeinen Formel (I) können je nach Art und Verknüpfung der Substituenten als Stereoisomere vorliegen. Die durch ihre spezifische Raumform definierten möglichen Stereoisomere, wie Enantiomere, Diastereomere, Z- und E- Isomere sind alle von der allgemeinen Formel (I) umfasst. Sind beispielsweise eine oder mehrere Alkenylgruppen vorhanden, so können Diastereomere (Z- und E- Isomere) auftreten. Sind beispielsweise ein oder mehrere asymmetrische Cycloalkyl substituents, for example in the form of an N- (di-n-butyl-sulfanylidene), N- (di-iso-propyl-sulfanyliden), N- (di-n-propyl-sulfanyliden), N- (di-n-pentyl -sulfanylidene), N- (diisobutylsulfanylidene), N- (cyclobutylisopropylsulfanylidene), N- (n-propylisopropylsulfanylidene), N- (cyclopropylisopropyl) sulfanylidene) or N- (iso-butylisopropylsulfanylidene) unit. Depending on the nature and linkage of the substituents, the compounds of the general formula (I) can exist as stereoisomers. The possible stereoisomers defined by their specific spatial form, such as enantiomers, diastereomers, Z and E isomers, are all encompassed by the general formula (I). If, for example, one or more alkenyl groups are present, diastereomers (Z and E isomers) can occur. For example, are one or more asymmetric
Kohlenstoffatome vorhanden, so können Enantiomere und Diastereomere auftreten. Stereoisomere lassen sich aus den bei der Herstellung anfallenden Gemischen nach üblichen Trennmethoden erhalten. Die chromatographische Trennung kann sowohl im analytischen Maßstab zur Feststellung des Enantiomerenüberschusses bzw. des Diastereomerenüberschusses, wie auch im präparativen Maßstab zur Herstellung von Prüfmustern für die biologische Ausprüfung erfolgen. Ebenso können Stereoisomere durch Einsatz stereoselektiver Reaktionen unter Verwendung optisch aktiver  Carbon atoms present, so enantiomers and diastereomers may occur. Stereoisomers can be obtained from the resulting mixtures in the preparation by conventional separation methods. The chromatographic separation can be carried out both on an analytical scale to determine the enantiomeric excess or the diastereomeric excess, as well as on a preparative scale for the preparation of test samples for the biological assay. Likewise, stereoisomers can be prepared by using stereoselective reactions using optically active
Ausgangs- und/oder Hilfsstoffe selektiv hergestellt werden. Die Erfindung betrifft somit auch alle Stereoisomeren, die von der allgemeinen Formel (I) umfasst, jedoch nicht mit ihrer spezifischen Stereoform angegeben sind, sowie deren Gemische. Starting and / or auxiliaries are selectively prepared. The invention thus relates also all stereoisomers, which comprises the general formula (I), but are not specified with their specific stereoform, and mixtures thereof.
Die oben angeführten allgemeinen oder in Vorzugsbereichen angeführten The general or preferred ones mentioned above
Restedefinitionen gelten sowohl für die Endprodukte der Formel (I) als auch  Residue definitions apply both to the end products of the formula (I) and
entsprechend für die jeweils zur Herstellung benötigten Ausgangs- und  accordingly for each required for the production of starting and
Zwischenprodukte. Diese Restedefinitionen können untereinander, als auch zwischen den angegebenen bevorzugten Bereichen vertauscht werden. Der Begriff„Nutzpflanzen", wie hier verwendet, bezeichnet Kulturpflanzen, die als Pflanzen für die Gewinnung von Nahrungsmitteln, Futtermitteln oder für technische Zwecke eingesetzt werden.  Intermediates. These residue definitions can be interchanged with each other as well as between the specified preferred ranges. The term "crops" as used herein refers to crops used as plants for the production of food, feed or for technical purposes.
Die Verbindungen der allgemeinen Formel (I) können hergestellt werden, indem man beispielsweise The compounds of the general formula (I) can be prepared by, for example,
(a) eine Carbonsäure der allgemeinen Formel (II) (a) a carboxylic acid of the general formula (II)
worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restedefinition definiert sind, wherein R 1 and R 2 are defined as in the compound of formula (I) to be prepared according to the above definition of the residue,
mit einem Amin der Formel (III) oder dessen Salz,  with an amine of the formula (III) or its salt,
R3 R 3
worin R3 und R4 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind, gegebenenfalls in Gegenwart eines carbonsäureaktivierenden Reagenzes, beispielsweise Ν,Ν-Carbonyldiimidazol (CDI), oder eines wasserentziehenden Mittels, beispielsweise Dicyclohexylcarbodiimid (DCC), zur Verbindung der Formel (I) umsetzt oder einen Carbonsäureester der allgemeinen Formel (IV) wherein R 3 and R 4 are defined as in the compound of formula (I) to be prepared according to the above definition of the radical, if appropriate in the presence of a carboxylic acid-activating reagent, for example Ν, Ν-carbonyldiimidazole (CDI), or of a dehydrating agent, for example dicyclohexylcarbodiimide (DCC), to give the compound of the formula (I) or a carboxylic ester of the general formula (IV)
worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind und„Alkyl" einen Alkylrest, beispielsweise Methyl oder Ethyl, bedeutet, mit einem Amin der Formel (III) oder dessen Salz, in which R 1 and R 2 are defined as in the compound of the formula (I) to be prepared according to the above definition and "alkyl" is an alkyl radical, for example methyl or ethyl, with an amine of the formula (III) or its salt,
R3 R 3
I  I
H %4 (MI) H % 4 (MI)
worin R3 und R4 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind, zur Verbindung der Formel (I) umsetzt oder ein Carbonsäurehalogenid oder -anhydrid der allgemeinen Formel (V), wherein R 3 and R 4 are as defined in the compound of formula (I) to be prepared according to the above definition, to give the compound of formula (I) or a carboxylic acid halide or anhydride of general formula (V),
worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind und Hai ein Halogenatom, beispielsweise Chlor, oder einen Acyloxyrest bedeutet, mit einem Amin der Formel (III) oder dessen Salz, wherein R 1 and R 2 are as defined in the compound of formula (I) to be prepared according to the above definition and Hai is a halogen atom, for example Chlorine, or an acyloxy radical, with an amine of the formula (III) or its salt,
R3 R 3
I  I
H %4 (Hl) worin R3 und R4 wie in der herzustellenden Verbindung der Formel (I) definiert sind, zur Verbindung der Formel (I) umsetzt, im Falle, dass R3 und R4 in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition jeweils Wasserstoff bedeutet, H% 4 (Hl) wherein R 3 and R 4 are as for the compound of formula (I) are defined, to give the compound of formula (I), in the event that R 3 and R 4 (for the compound of formula I) according to the above radical definition in each case hydrogen,
eine Verbindung der Formel (VI),  a compound of the formula (VI)
worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert ist und "AI kyl" einen Alkylrest, beispielsweise Methyl oder Ethyl, bedeutet, wherein R 1 and R 2 are as defined in the compound of formula (I) to be prepared according to the above definition of the radical and "AI kyl" is an alkyl radical, for example methyl or ethyl,
mit Malonsäurediamid zur Verbindung der Formel (I) umsetzt.  reacted with Malonsäurediamid to the compound of formula (I).
Die Amidbildungen nach Variante (a) können beispielsweise in einem inerten organischen Lösungsmittel in einem Temperaturbereich zwischen 0 °C und 150 °C, vorzugsweise 0 °C und 50 °C durchgeführt werden. Als organische Lösungsmittel eignen sich beispielsweise polare protische oder aprotische Lösungsmittel wie Ether, z. B. Diethylether, Tetrahydrofuran und Dioxan, oder Nitrile wie Acetonitril, oder Amide wie Dimethylformamid. The amide formations according to variant (a) can be carried out, for example, in an inert organic solvent in a temperature range between 0 ° C and 150 ° C, preferably 0 ° C and 50 ° C. Suitable organic solvents are, for example, polar protic or aprotic solvents such as ethers, eg. As diethyl ether, tetrahydrofuran and dioxane, or nitriles such as acetonitrile, or amides such as dimethylformamide.
Die Amidbildungen nach Variante (b) können beispielsweise in einem inerten organischen Lösungsmittel in einem Temperaturbereich zwischen 0 °C und 150 °C, vorzugsweise 50 °C und 100 °C durchgeführt werden. Als organische Lösungsmittel eignen sich beispielsweise polare protische oder aprotische Lösungsmittel wie Ether, z. B. Tetrahydrofuran und Dioxan, oder Nitrile wie Acetonitril, oder Amide wie The amide formations according to variant (b) can be carried out, for example, in an inert organic solvent in a temperature range between 0 ° C and 150 ° C, preferably 50 ° C and 100 ° C. Suitable organic solvents are, for example, polar protic or aprotic solvents such as ethers, z. For example, tetrahydrofuran and dioxane, or nitriles such as acetonitrile, or amides such as
Dimethylformannid. Bevorzugt ist jedoch die Amidbildung nach Variante (b) bei erhöhten Temperaturen durch Umsetzung der Reaktionspartner in Substanz. Dimethylformannid. Preferably, however, the amide formation according to variant (b) at elevated temperatures by reaction of the reactants in substance.
Die Amidbildungen nach Variante (c) können beispielsweise in Gegenwart eines säurebindenden Mittels in einem inerten organischen Lösungsmittel in einem The amide formations according to variant (c) can, for example, in the presence of an acid-binding agent in an inert organic solvent in a
Temperaturbereich zwischen 0 °C und 150 °C, vorzugsweise 0 °C und 50 °C Temperature range between 0 ° C and 150 ° C, preferably 0 ° C and 50 ° C.
durchgeführt werden. Als organische Lösungsmittel eignen sich beispielsweise polare protische oder aprotische Lösungsmittel wie Ether, z. B. Diethylether, Tetrahydrofuran und Dioxan, oder Nitrile wie Acetonitril, oder Amide wie Dimethylformamid. be performed. Suitable organic solvents are, for example, polar protic or aprotic solvents such as ethers, eg. As diethyl ether, tetrahydrofuran and dioxane, or nitriles such as acetonitrile, or amides such as dimethylformamide.
Säurebindende Mittel sind beispielsweise Alkali- oder Erdalkalimetallcarbonate wie z. B. Natrium-, Kalium- oder Calciumcarbonat, Alkali- oder Erdalkalimetallhydroxide, wie Natrium-, Kalium oder Calciumhydroxid, oder Alkalimetallhydride oder-amide, wie Natrium- oder Kaliumhydrid oder-amid, oder auch organische Basen, wie Triethylamin, Pyridin, Dimethylaminopyridin, DBU (1 ,8-Diazabicyclo[5.4.0]-undec-7-en), DBN (1 ,5- Diazabicyclo[4.3.0]non-5-en) und 1 ,4-Diazabicyclo[2.2.2]octan. Acid-binding agents are, for example, alkali metal or alkaline earth metal carbonates such as. Example, sodium, potassium or calcium carbonate, alkali metal or alkaline earth metal hydroxides such as sodium, potassium or calcium hydroxide, or alkali metal hydrides or amides such as sodium or potassium hydride or amide, or organic bases such as triethylamine, pyridine, dimethylaminopyridine, DBU (1,8-diazabicyclo [5.4.0] undec-7-ene), DBN (1,5-diazabicyclo [4.3.0] non-5-ene) and 1,4-diazabicyclo [2.2.2] octane ,
Die Amidbildungen nach Variante (d) können analog den Verfahren durchgeführt werden, wie sie in EP 522392 und Helv. Chim. Acta 71 (1988) 596-601 und GB The amide formations according to variant (d) can be carried out analogously to the methods described in EP 522392 and Helv. Chim. Acta 71 (1988) 596-601 and GB
2305174 beschrieben sind. Das Malonsäurediamid kann in der Regel in einem organischen wasserfreien polaren protischen oder aprotischen Lösungsmittel, beispielsweise in einem Alkohol, mit einer starken Base wie einem Alkalimetall, Alkalimetallhydrid oder Alkalimetallalkoholat in ein reaktives Salz überführt und dann mit der Verbindung der Formel (VI) umgesetzt werden. Die Umsetzung mit der 2305174 are described. The malonamide may typically be converted to a reactive salt in an organic anhydrous polar protic or aprotic solvent, for example in an alcohol, with a strong base such as an alkali metal, alkali metal hydride or alkali metal alcoholate and then reacted with the compound of formula (VI). The implementation with the
Verbindung (VI) kann in der Regel in einem Temperaturbereich zwischen 0 °C und dem Siedepunkt des Lösungsmittels (je nach Lösungsmittel etwa bis 150 °C) durchgeführt werden. Compound (VI) can be carried out usually in a temperature range between 0 ° C and the boiling point of the solvent (depending on the solvent about to 150 ° C).
Die Verbindungen der allgemeinen Formeln (II), (III), (IV) und (V) sind entweder kommerziell erhältlich oder können nach oder analog dem Fachmann bekannten Methoden hergestellt werden (z. B. Helv. Chim. Acta 71 (1988) 596; EP 502740; EP 522392). The compounds of the general formulas (II), (III), (IV) and (V) are either commercially available or can be prepared by methods analogous to those known to the person skilled in the art (for example Helv. Chim. Acta 71 (1988) 596 EP 502740; EP 522392).
So sind beispielsweise die Verbindungen der Formel (IVa), worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind , For example, the compounds of the formula (IVa) wherein R 1 and R 2 are defined as in the compound of formula (I) to be prepared according to the above definition of the radical,
durch Umsetzung von Alkoxyvinylethern der Formel (VI), worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind, mit Malonsäurealkylester-amiden der Formel (VII) zugänglich. by reaction of alkoxyvinyl ethers of the formula (VI) in which R 1 and R 2 are defined as described in the compound of the formula (I) according to the above definition, with malonic acid alkyl ester amides of the formula (VII).
(VI) (VII) Die Edukte der Formel (VI), worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind, sind entweder kommerziell erhältlich oder können nach bekannten Methoden hergestellt werden (z. B. Synthesis 2000, 738-742; J. Fluor. Chem., 107, 2001 , 285-300; Organometallics 15, 1996, 5374- 5379). (VI) (VII) The starting materials of formula (VI) wherein R 1 and R 2 are as for the compound of formula (I) are defined according to the above residue definition, are either commercially available or can be prepared (e.g. by known methods. Synthesis 2000, 738-742; J. Fluor. Chem., 107, 2001, 285-300; Organometallics 15, 1996, 5374-5379).
Die Verbindungen der Formel (IV), worin R2 ein Halogenatom bedeutet, lassen sich durch übliche Halogenierungen aus den Verbindungen der Formel (IVa) herstellen. Als Halogenierungsmittel für Pyridine finden beispielsweise Chlor (J. Org. Chem. 23, 1958, 1614), Brom (Synth. Commun. 19, 1989, 553-560; US P 2532055), lod The compounds of the formula (IV) in which R 2 is a halogen atom can be prepared by customary halogenations from the compounds of the formula (IVa). Chlorine (J. Org. Chem., 23, 1958, 1614), bromine (Synth., Commun., 19, 1989, 553-560, US Pat
(Tetrahedron Lett. 45, 2004, 6633-6636), Natriumhypochlorit (J. Org. Chem. 49, 1984, 4784-4786; J. Med. Chem. 36, 1993, 2676-2688, US P 4960896), Natriumhypobromit (J. Med. Chem. 32, 1989, 2178-2199), Thionylchlorid (Organic Letters, 6, 2004, 3-5), N-Chlorsuccinimid (J. Med. Chem. 46, 2003, 702-715), N-Bromsuccinimid (Chem. Pharm. Bull. 48, 2000, 1847-1853), N-Iodsuccinimid (J. Med. Chem. 36, 1993, 2676- 2788) Verwendung. (Tetrahedron Lett. 45, 2004, 6633-6636), sodium hypochlorite (J. Org. Chem. 49, 1984, 4784-4786; J. Med. Chem. 36, 1993, 2676-2688, USP 4960896), sodium hypobromite ( J. Med. Chem. 32, 1989, 2178-2199), thionyl chloride (Organic Letters, 6, 2004, 3-5), N-chlorosuccinimide (J. Med. Chem. 46, 2003, 702-715), N- Bromosuccinimide (Chem. Pharm. Bull. 48, 2000, 1847-1853), N-iodosuccinimide (J. Med. Chem. 36, 1993, 2676-2788).
Ferner können die Verbindungen der allgemeinen Formel (IV), worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind, aus den Verbindungen der allgemeinen Formel (IVa), worin R1 und R2 wie in der herzustellenden Verbindung der Formel (I) gemäß obiger Restdefinition definiert sind, sukzessive durch Nitrierung (z. B. J. Med. Chem. 36, 1993, 2676-2688; J. Heterocycl. Chem. 33, 1996, 287-294), Reduktion (z. B. J. Med. Chem. 33, 1990, 1859-1865), Diazotierung und anschließender Umsetzung der Diazoniumsalze mittels Sandmeyerbzw. Schiemannn-Reaktion hergestellt werden. Further, the compounds of the general formula (IV) wherein R 1 and R 2 may be as in for the compound of formula (I) are defined according to the above radical definition of the compounds of the general formula (IVa) wherein R 1 and R 2 are as for the compound of formula (I) are defined according to the above residue definition, successively (by nitration BJ Med Chem 36, 1993, 2676-2688, J. Heterocycl Chem 33, 1996, 287-294), reduction (eg J. Med. Chem subsequent implementation of the diazonium salts by means of Sandmeyerbzw. Schiemannn reaction are produced.
Die 1H-NMR-spektroskopischen Daten, die für die im nachfolgenden Abschnitt beschriebenen chemischen Beispiele angegeben sind (400 MHz bei 1H-NMR, The 1 H NMR spectroscopic data given for the chemical examples described in the following section (400 MHz at 1 H NMR,
Lösungsmittel CDCI3 oder DMSO-d6 (nachfolgend gleichermaßen auch als DMSO bezeichnet), interner Standard: Tetrametylsilan δ = 0.00 ppm), wurden mit einem Gerät der Firma Bruker erhalten. Die bezeichneten Signale haben die nachfolgend Solvent CDCl 3 or DMSO-d6 (hereinafter also referred to as DMSO), internal standard: tetramethylsilane δ = 0.00 ppm), were obtained with a device from Bruker. The designated signals have the following
aufgeführten Bedeutungen: br. = breit(es); s = Singulett, d = Dublett, t = Triplett, m = Multiplett, q = Quartett, sext = Sextett, sept = Septett. meanings listed: br. = broad (it); s = singlet, d = doublet, t = triplet, m = multiplet, q = quartet, sext = sextet, sept = septet.
Herstellungsbeispiele Preparation Examples
Beispiel 32, gemäß nachstehender Tabelle A 5,6-Dimethyl-2-oxo-N-(pentan-2-yl)-1 ,2-dihydropyridin-3-carboxamid Example 32, according to the following Table A 5,6-dimethyl-2-oxo-N- (pentan-2-yl) -1,2-dihydropyridine-3-carboxamide
32.1 ) (E/Z)-Natrium-2-methyl-3-oxobut-1 -en-1 -olat 32.1) (E / Z) -sodium-2-methyl-3-oxobut-1-en-1-olate
Unter einer Argonatmosphäre wurde Natrium (31 .9 g, 1 .39 mol) bei Raumtemperatur in Methanol (197.8 g, 250 ml, 6.17 mol) gelöst, mit 800 ml Diethylether versetzt und im Eisbad auf 0 °C abgekühlt. Dazu wurde eine Mischung aus 2-Butanon (100.0 g, 1 .39 mol) und Ameisensäureethylester (102.7 g, 1 .39 mol) getropft. Nachbeendeter Zugabe wurde die Reaktionsmischung für 16 h bei Raumtemperatur nachgerührt. Der ausgefallene Feststoff wurde abgesaugt, mit Diethylether nachgewaschen 2 h bei 55 °C im Vakuum getrocknet. Es wurden 81 .8 g (48% d. Th.) eines farblosen Feststoffs erhalten. Under an argon atmosphere, sodium (31 .9 g, 1 .39 mol) was dissolved in methanol (197.8 g, 250 ml, 6.17 mol) at room temperature, admixed with 800 ml of diethyl ether and cooled to 0 ° C. in an ice bath. For this purpose, a mixture of 2-butanone (100.0 g, 1 .39 mol) and ethyl formate (102.7 g, 1 .39 mol) was added dropwise. After completion of the addition, the reaction mixture was stirred for 16 h at room temperature. The precipitated solid was filtered off with suction, washed with diethyl ether for 2 h at 55 ° C dried in vacuo. 81.8 g (48% of theory) of a colorless solid were obtained.
1H-NMR (400 MHz, DMSO-de): δ = 9.07 (s, 1 H), 1 .89 (s, 3H), 1 .39 (s, 3H). 1 H-NMR (400 MHz, DMSO-de): δ = 9.07 (s, 1H), 1 .89 (s, 3H), 1 .39 (s, 3H).
32.2) 5,6-Dimethyl-2-oxo-1 ,2-dihydropyridin-3-carbonitril 32.2) 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Zu einer Lösung von (E/Z)-Natrium-2-methyl-3-oxobut-1 -en-1 -olat (77.6 g, 0.64 mol) in 480 ml Wasser wurde Cyanacetamid (49.0 g, 0.70 mol) gegeben. Die Mischung wurde mit einer Piperidinacetat-Lösung (hergestellt aus Essigsäure (9.16 g, 8.75 ml, 0.15 mol), 21 .2 ml Wasser und Piperidin (13.0 g, 15.1 ml, 0.15 mol)) versetzt, 4 h am Rückfluss erhitzt und 16 h bei Raumtemperatur nachgerührt. Die Reaktionsmischung wurde mit Essigsäure (75.5 g, 72 ml, 1 .26 mol) versetzt, wobei ein hellgelblicher Feststoff ausfiel. Dieser wurde abgesaugt, mit Wasser gewaschen und für 2 h bei 55 °C im Vakuum getrocknet. Es wurden 66.4 g (70% d. Th.) eines hellgelblichen To a solution of (E / Z) -sodium-2-methyl-3-oxobut-1-en-1-olate (77.6 g, 0.64 mol) in 480 ml of water was added cyanoacetamide (49.0 g, 0.70 mol). The mixture was treated with a piperidine acetate solution (prepared from acetic acid (9.16 g, 8.75 mL, 0.15 mol), 21 .2 mL water and piperidine (13.0 g, 15.1 mL, 0.15 mol)), refluxed for 4 h and 16 Stirred at room temperature. To the reaction mixture was added acetic acid (75.5 g, 72 ml, 1.26 mol), whereby a pale yellow solid precipitated. This was filtered off, washed with water and dried for 2 h at 55 ° C in a vacuum. There were 66.4 g (70% of theory) of a pale yellow
Feststoffs erhalten Solid obtained
1H-NMR (400 MHz, DMSO-de): δ = 7.87 (s, 1 H), 2.23 (s, 3H), 1 .97 (s, 3H). 1 H-NMR (400 MHz, DMSO-de): δ = 7.87 (s, 1H), 2.23 (s, 3H), 1 .97 (s, 3H).
32.3) 5,6-Dimethyl-2-oxo-1 ,2-dihydropyridin-3-carbonsäure 32.3) 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
Eine Mischung aus 5,6-Dimethyl-2-oxo-1 ,2-dihydropyridin-3-carbonitril (43.0 g, 0.29 mol) und 6 N Natronlauge (200 ml, 1 .20 mol) wurden in einem Autoklaven für 4 h auf 145 °C erhitzt. Nachbeendeter Reaktion wurde die Reaktionsmischung unter A mixture of 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (43.0 g, 0.29 mol) and 6N sodium hydroxide solution (200 ml, 1.20 mol) was added in an autoclave for 4 h Heated to 145 ° C. After completion of the reaction, the reaction mixture was added
Eisbadkühlung mit konz. Salzsäure auf pH 1 -2 eingestellt, wobei ein Feststoff ausfiel. Dieser wurde abgesaugt, mit Wasser gewaschen und für 2 h bei 55 °C im Vakuum getrocknet. Es wurden 34.8 g (68% d. Th.) eines farblosen Feststoffs erhalten. Ice bath cooling with conc. Hydrochloric acid adjusted to pH 1-2, wherein a solid precipitated. This was filtered off, washed with water and dried for 2 h at 55 ° C in a vacuum. There were obtained 34.8 g (68% of theory) of a colorless solid.
1H-NMR (400 MHz, DMSO-de): δ = 14.9 (s, 1 H), 13.2 (br.s, 1 H), 8.18 (s, 1 H), 2.34 (s, 3H), 2.1 (s, 3H). 32.4) 5,6-Dimethyl-2-oxo-N-(pentan-2-yl)-1 ,2-dihydropyridin-3-carboxannid 1H-NMR (400 MHz, DMSO-de): δ = 14.9 (s, 1H), 13.2 (br.s, 1H), 8.18 (s, 1H), 2.34 (s, 3H), 2.1 (s , 3H). 32.4) 5,6-dimethyl-2-oxo-N- (pentan-2-yl) -1,2-dihydropyridine-3-carboxannide
Eine Mischung von 5,6-Dimethyl-2-oxo-1 ,2-dihydropyhdin-3-carbonsäure (300 mg, 1 .80 mmol) und 1 ,1 -Carbonyldiimidazol (CDI, 162.2 mg, 1 .56 mmol) wurden in 3.00 ml THF vorgelegt und für 1 h bei 75 °C gerührt. Nach Abkühlen auf Raumtemperatur wurde 2-Pentylamin (312.9 mg, 5.00 ml, 3.59 mmol) zugegeben und die A mixture of 5,6-dimethyl-2-oxo-1,2-dihydropyhdine-3-carboxylic acid (300 mg, 1 .80 mmol) and 1,1-carbonyldiimidazole (CDI, 162.2 mg, 1.56 mmol) was added in Submitted 3.00 ml of THF and stirred for 1 h at 75 ° C. After cooling to room temperature, 2-pentylamine (312.9 mg, 5.00 ml, 3.59 mmol) was added and the
Reaktionsmischung für 16 h bei Raumtemperatur gerührt. Nach Zugabe von verd. Salzsäure (0.5 N) wurde die Mischung mit Dichlormethan extrahiert und die Reaction mixture stirred for 16 h at room temperature. After addition of dilute hydrochloric acid (0.5 N), the mixture was extracted with dichloromethane and the
organischen Phasen getrocknet. Nach Entfernen der Lösungsmittel i. Vak. und säulenchromatographischer Reinigung wurden 178.3 mg (40% d. Th.) eines farblosen Feststoffs erhalten. dried organic phases. After removal of the solvents i. Vak. and purified by column chromatography, 178.3 mg (40% of theory) of a colorless solid were obtained.
1H-NMR (400 MHz, CDCIs): δ = 12.7 (br.s, 1 H), 9.36 (br.s, 1 H), 8.42 (s, 1 H), 4.16, (sept., 1 H), 2.35 (s, 3H), 2.15 (s, 3H), 1 .60 - 1 .30 (m, 4H), 1 .21 (d, 3H), 0.97 (t, 3H). 1 H-NMR (400 MHz, CDCIs): δ = 12.7 (br.s, 1H), 9.36 (br.s, 1H), 8.42 (s, 1H), 4.16, (sept., 1H) , 2.35 (s, 3H), 2.15 (s, 3H), 1 .60 - 1 .30 (m, 4H), 1 .21 (d, 3H), 0.97 (t, 3H).
Beispiel 665, gemäß nachstehender Tabelle A Example 665, according to Table A below
N-Cyclopropyl-5-ethyl-2-oxo-6-(pentafluorethyl)-1 ,2-dihydropyridin-3-carboxamid 665.1 ) (E/Z)-4-(Ethoxymethylen)-1 ,1 ,1 ,2,2-pentafluorhexan-3-on N-cyclopropyl-5-ethyl-2-oxo-6- (pentafluoroethyl) -1,2-dihydropyridine-3-carboxamide 665.1) (E / Z) -4- (ethoxymethylene) -1, 1, 1, 2,2 -pentafluorhexan-3-one
(E/Z)-1 -Butenethylether (21 .0 g, 0.21 mol) wurde zusammen mit Pyridin (16.6 g, 17 ml, 0.21 mol) in 600 ml Acetonitril vorgelegt und auf 10 °C gekühlt. Zu der Mischung wurde langsam Pentafluoressigsäureanhydrid (65.0 g, 41 .4 ml, 0.21 mol) getropft und nach beendeter Zugabe noch 16 h bei Raumtemperatur nachgerührt. Die (E / Z) -1-Butenethyl ether (21 .0 g, 0.21 mol) was charged together with pyridine (16.6 g, 17 ml, 0.21 mol) in 600 ml of acetonitrile and cooled to 10 ° C. Pentafluoroacetic anhydride (65.0 g, 41.4 ml, 0.21 mol) was slowly added dropwise to the mixture and stirred for a further 16 h at room temperature after the end of the addition. The
Reaktionsmischung wurde mit Wasser versetzt und mit Dichlormethan extrahiert. Die org. Phasen wurden mit verd. Salzsäure und Wasser gewaschen, getrocknet und die Lösungsmittel abdestilliert. Man erhielt 50.5 g (98% d. Th.) als farbloses Öl.  The reaction mixture was treated with water and extracted with dichloromethane. The org. Phases were washed with dil. Hydrochloric acid and water, dried and the solvents distilled off. 50.5 g (98% of theory) were obtained as a colorless oil.
1H-NMR (400 MHz, CDCI3): δ = 7.60 (s, 1 H), 4.21 (q, 2H), 2.32 (q, 2H), 1 .41 (t, 3H), 0.95 (t, 3H). 1 H NMR (400 MHz, CDCl 3): δ = 7.60 (s, 1H), 4.21 (q, 2H), 2.32 (q, 2H), 1 .41 (t, 3H), 0.95 (t, 3H).
665.2) 5-Ethyl-2-oxo-6-(pentafluorethyl)-1 ,2-dihydropyridin-3-carbonsäuremethylester Unter einer Argonatmosphäre wurde Natrium (5.60 g, 0.24 mol) bei Raumtemperatur in 600 ml Methanol gelöst. Nach Zugabe von (E/Z)-4-(Ethoxymethylen)-1 ,1 ,1 ,2,2- pentafluorhexan-3-οη (50.0 g, 0.20 mol) und Methylmalonamat (23.8 g, 30 ml, 0.20 mol) wurde die Reaktionsmischung für 4 h am Rückfluss erhitzt. Nach beendeter Reaktion wurde das Methanol abdestilliert, der Rückstand mit Wasser versetzt und mit Dichlormethan extrahiert. Die wässrige Phase wurde mit verd. Salzsäure auf pH 2 eingestellt, wobei ein Feststoff ausfiel. Nach Absaugen des Feststoffs und Trocknung i. Vak. wurden 33.2 g (55% d. Th.) erhalten. 665.2) 5-ethyl-2-oxo-6- (pentafluoroethyl) -1,2-dihydropyridine-3-carboxylic acid methyl ester Under an argon atmosphere, sodium (5.60 g, 0.24 mol) was dissolved in 600 ml of methanol at room temperature. After addition of (E / Z) -4- (ethoxymethylene) -1,1,1,2,2-pentafluorohexan-3-one (50.0 g, 0.20 mol) and methylmalonamate (23.8 g, 30 ml, 0.20 mol) the reaction mixture heated at reflux for 4 h. After completion of the reaction, the methanol was distilled off, the residue was added with water and extracted with dichloromethane. The aqueous phase was adjusted to pH 2 with dilute hydrochloric acid, whereby a solid precipitated. After filtering off the solid and drying i. Vak. 33.2 g (55% of theory) were obtained.
1H-NMR (400 MHz, CDCIs): δ = 1 1 .9 (br.s, 1 H), 8.21 (s, 1 H), 3.86 (s, 3H), 2.74 - 2.71 (m, 2H), 1 .17 (t, 3H). 1 H-NMR (400 MHz, CDCIs): δ = 1 1 .9 (br.s, 1H), 8.21 (s, 1H), 3.86 (s, 3H), 2.74 - 2.71 (m, 2H), 1 .17 (t, 3H).
665.3) N-Cyclopropyl-5-ethyl-2-oxo-6-(pentafluorethyl)-1 ,2-dihydropyridin-3- carboxamid Eine Mischung aus 5-Ethyl-2-oxo-6-(pentafluorethyl)-1 ,2-dihydropyridin-3- carbonsäuremethylester (500 mg, 1 .67 mmol) und Cyclopropylamin (1 14 mg, 1 .00 ml, 2.00 mmol) in 5.00 ml Acetonitril wurde für 16 h bei Raumtemperatur gerührt. Nach beendeter Reaktion wurde mit verd. Salzsäure auf pH 2 eingestellt und der dabei ausgefallene Feststoff abgesaugt. Nach Trocknung i. Vak. wurden 346 mg (64% d. Th.) als farbloser Feststoff erhalten. 665.3) N-cyclopropyl-5-ethyl-2-oxo-6- (pentafluoroethyl) -1,2-dihydropyridine-3-carboxamide A mixture of 5-ethyl-2-oxo-6- (pentafluoroethyl) -1, 2- Methyl dihydropyridine-3-carboxylate (500 mg, 1.67 mmol) and cyclopropylamine (14 mg, 1 .00 mL, 2.00 mmol) in 5.00 mL acetonitrile were stirred for 16 h at room temperature. After the reaction had ended, it was adjusted to pH 2 with dilute hydrochloric acid and the precipitated solid was filtered off with suction. After drying i. Vak. 346 mg (64% of theory) were obtained as a colorless solid.
1H-NMR (400 MHz, DMSO-de): δ = 13.0 (br.s, 1 H), 8.73 (br.s, 1 H), 8.25 (s, 1 H), 2.90 - 2.82 (m, 1 H), 2.75 - 2.62 (m, 2H), 1 .17 (t, 3H), 0.80 - 0.70 (m, 2H), 0.61 - 0.55 (m, 2H). 1 H-NMR (400 MHz, DMSO-de): δ = 13.0 (br.s, 1H), 8.73 (br.s, 1H), 8.25 (s, 1H), 2.90 - 2.82 (m, 1 H), 2.75-2.62 (m, 2H), 1 .17 (t, 3H), 0.80-0.70 (m, 2H), 0.61-0.55 (m, 2H).
Beispiel 219, gemäß nachstehender Tabelle A Example 219, according to Table A below
N,5-Dimethyl-2-oxo-N-phenyl-6-(trifluormethyl)-1 ,2-dihydropyridin-3-carboxamid 2193.1 ) (E/Z)-4-Ethoxy-1 ,1 ,1 -trifluor-3-methylbut-3-en-2-on N, 5-Dimethyl-2-oxo-N-phenyl-6- (trifluoromethyl) -1,2-dihydropyridine-3-carboxamide 2193.1) (E / Z) -4-ethoxy-1,1,1-trifluoro-3 -methylbut-3-en-2-one
(E/Z)-1 -Ethylpropylether (25.0 g, 32.2 ml, 0.28 mol) wurde zusammen mit Pyridin (22.5 g, 23 ml, 0.28 mol) in 500 ml Chloroform vorgelegt und auf 5 °C gekühlt. Zu der Mischung wurde langsam Pentafluoressigsäureanhydrid (60.0 g, 40.3 ml, 0.28 mol) getropft und nach beendeter Zugabe noch 16 h bei Raumtemperatur nachgerührt. Die Reaktionsmischung wurde mit Wasser versetzt und mit Dichlormethan extrahiert. Die org. Phasen wurden mit verd. Salzsäure und Wasser gewaschen, getrocknet und die Lösungsmittel abdestilliert. Man erhielt 43.8 g (84% d. Th.) als farbloses Öl. (E / Z) -1-ethyl-propyl ether (25.0 g, 32.2 ml, 0.28 mol) was charged together with pyridine (22.5 g, 23 ml, 0.28 mol) in 500 ml of chloroform and cooled to 5 ° C. To the Mixture was slowly added dropwise pentafluoroacetic anhydride (60.0 g, 40.3 ml, 0.28 mol) and stirred for a further 16 h at room temperature after completion of the addition. The reaction mixture was added with water and extracted with dichloromethane. The org. Phases were washed with dil. Hydrochloric acid and water, dried and the solvents distilled off. 43.8 g (84% of theory) were obtained as a colorless oil.
1H-NMR (400 MHz, CDCIs): δ = 7.55 (s, 1 H), 4.20 (q, 2H), 1 .70 (s, 3H), 1 .40 (t, 3H). 1 H-NMR (400 MHz, CDCIs): δ = 7.55 (s, 1H), 4.20 (q, 2H), 1 .70 (s, 3H), 1 .40 (t, 3H).
2193.2) 5-Methyl-2-oxo-6-(trifluormethyl)-1 ,2-dihydropyridin-3-carbonsäuremethylester 2193.2) 5-Methyl-2-oxo-6- (trifluoromethyl) -1,2-dihydropyridine-3-carboxylic acid methyl ester
Unter einer Argonatmosphäre wurde Natrium (8.69 g, 0.38 mol) bei Raumtemperatur in 1 I Methanol gelöst. Nach Zugabe von (E/Z)-4-Ethoxy-1 ,1 ,1 -trifluor-3-methylbut-3- en-2-οη (66.1 g, 0.31 mol) und Methylmalonamat (36.9 g, 46.6 ml, 0.31 mol) wurde die Reaktionsmischung für 4 h am Rückfluss erhitzt. Nach beendeter Reaktion wurde das Methanol abdestilliert, der Rückstand mit Wasser versetzt und mit Dichlormethan extrahiert. Die wässrige Phase wurde mit verd. Salzsäure auf pH 2 eingestellt, wobei ein Feststoff ausfiel. Nach Absaugen des Feststoffs und Trocknung i. Vak. wurden 30.7 g (42% d. Th.) erhalten. Under an argon atmosphere, sodium (8.69 g, 0.38 mol) was dissolved at room temperature in 1 l of methanol. After addition of (E / Z) -4-ethoxy-1,1,1-trifluoro-3-methylbut-3-ene-2-one (66.1 g, 0.31 mol) and methylmalonamate (36.9 g, 46.6 ml, 0.31 mol ), the reaction mixture was heated at reflux for 4 h. After completion of the reaction, the methanol was distilled off, the residue was added with water and extracted with dichloromethane. The aqueous phase was adjusted to pH 2 with dilute hydrochloric acid, whereby a solid precipitated. After filtering off the solid and drying i. Vak. 30.7 g (42% of theory) were obtained.
1H-NMR (400 MHz, DMSO-de): δ = 12.0 (br.s, 1 H), 8.20 (s, 1 H), 3.85 (s, 3H), 2.34 (s, 3H). 1 H-NMR (400 MHz, DMSO-de): δ = 12.0 (br.s, 1H), 8.20 (s, 1H), 3.85 (s, 3H), 2.34 (s, 3H).
2193.3) 5-Methyl-2-oxo-6-(trifluormethyl)-1 ,2-dihydropyridin-3-carbonsäure 2193.3) 5-Methyl-2-oxo-6- (trifluoromethyl) -1,2-dihydropyridine-3-carboxylic acid
5-Methyl-2-oxo-6-(trifluormethyl)-1 ,2-dihydropyridin-3-carbonsäuremethylester (8.00 g, 34.0 mmol) wurde in 350 ml Methanol gelöst und mit 70 ml einer wässrigen Lösung von Lithiumhydroxid-Monohydrat (2.14 g, 51 .0 mmol) versetzt. Die Reaktionsmischung wurde für 16 h bei Raumtemperatur nachgerührt. Nachbeendeter Reaktion wurde die Reaktionsmischung unter Eisbadkühlung mit konz. Salzsäure auf pH 1 -2 eingestellt, wobei ein Feststoff ausfiel. Dieser wurde abgesaugt, mit Wasser gewaschen und für 2 h bei 55 °C im Vakuum getrocknet. Es wurden 6.30 g (84% d. Th.) eines farblosen Feststoffs erhalten. Methyl 5-methyl-2-oxo-6- (trifluoromethyl) -1,2-dihydropyridine-3-carboxylate (8.00 g, 34.0 mmol) was dissolved in 350 ml of methanol and washed with 70 ml of an aqueous solution of lithium hydroxide monohydrate (2.14 g , 51 .0 mmol). The reaction mixture was stirred for 16 h at room temperature. After completion of the reaction, the reaction mixture under ice bath cooling with conc. Hydrochloric acid adjusted to pH 1-2, wherein a solid precipitated. This was filtered off, washed with water and dried for 2 h at 55 ° C in a vacuum. There was obtained 6.30 g (84% of theory) of a colorless solid.
1H-NMR (400 MHz, DMSO-de): δ = 8.22 (s, 1 H), 2.35 (s, 3H). 2193.4) N,5-Dimethyl-2-oxo-N-phenyl-6-(trifluormethyl)-1 ,2-dihydropyridin-3- carboxamid 1 H-NMR (400 MHz, DMSO-de): δ = 8.22 (s, 1H), 2.35 (s, 3H). 2193.4) N, 5-dimethyl-2-oxo-N-phenyl-6- (trifluoromethyl) -1,2-dihydropyridine-3-carboxamide
5-Methyl-2-oxo-6-(trifluormethyl)-1 ,2-dihydropyridin-3-carbonsäure (150 mg, 0.69 mmol) wurde in 5 ml THF vorgelegt und mit 1 ,1 -Carbonyldiimidazol (CDI, 220.0 mg, 1 .36 mmol) versetzt. Die Reaktionsmischung wurde für 1 h bei Raumtemperatur gerührt. Nach Zugabe von N-Methylanilin (145.0 mg, 1 .36 mmol) wurde die Mischung für 16 h bei Raumtemperatur gerührt. Nach Zugabe Wasser wurde die Mischung mit Dichlormethan extrahiert und die organischen Phasen getrocknet. Nach Entfernen der Lösungsmittel i. Vak. und säulenchromatographischer Reinigung wurden 85.0 mg (40% d. Th.) eines farblosen Öls erhalten. 5-Methyl-2-oxo-6- (trifluoromethyl) -1,2-dihydropyridine-3-carboxylic acid (150 mg, 0.69 mmol) was initially charged in 5 ml of THF and treated with 1,1-carbonyldiimidazole (CDI, 220.0 mg, 1 .36 mmol). The reaction mixture was stirred for 1 h at room temperature. After addition of N-methylaniline (145.0 mg, 1 .36 mmol), the mixture was stirred for 16 h at room temperature. After adding water, the mixture was extracted with dichloromethane and the organic phases were dried. After removal of the solvents i. Vak. and purified by column chromatography, 85.0 mg (40% of theory) of a colorless oil were obtained.
1H-NMR (400 MHz, DMSO-de): δ = 1 1 .6 (br.s, 1 H), 7.67 (br.s, 1 H), 7.30 - 7.15 (br.m, 5H), 2.33 (br.s, 3H), 2.20 (br.s, 3H). Beispiel 1744, gemäß nachstehender Tabelle A 1 H-NMR (400 MHz, DMSO-de): δ = 1 1 .6 (bs, 1 H), 7.67 (br.s, 1 H), 7:30 to 7:15 (br.m, 5H), 2:33 (br.s, 3H), 2.20 (br.s, 3H). Example 1744, according to Table A below
1 - ({5'-chlor-6'-[chlor(difluor)methyl]-2'-oxo-1 ',2'-dihydropyridin-3'-yl}carbonyl)-piperidin-1 - ({5'-chloro-6 '- [chloro (difluoro) methyl] -2'-oxo-1', 2'-dihydropyridin-3'-yl} carbonyl) piperidine
2- carbonsäureethylester 1744.1 ) (E/Z)-4-Butoxy-1 -chlor-1 ,1 -difluorbut-3-en-2-on Ethyl 2-carboxylate 1744.1) (E / Z) -4-butoxy-1-chloro-1,1-difluorobut-3-en-2-one
(E/Z)-1 -Butenethylether (41 .2 g, 53 ml, 0.40 mol) wurde zusammen mit Pyridin (31 .9 g, 33 ml, 0.40 mol) in 990 ml Chloroform vorgelegt und auf 5 °C gekühlt. Zu der Mischung wurde langsam Chlordifluoressigsäureanhydrid (100.0 g, 71 .4 ml, 0.40 mol) getropft und nach beendeter Zugabe noch 16 h bei Raumtemperatur nachgerührt. Die (E / Z) -1-Butenethyl ether (41.2 g, 53 ml, 0.40 mol) was charged together with pyridine (31 .9 g, 33 ml, 0.40 mol) in 990 ml of chloroform and cooled to 5 ° C. Chlorodifluoroacetic anhydride (100.0 g, 71.4 ml, 0.40 mol) was slowly added dropwise to the mixture and stirred for a further 16 h at room temperature after the end of the addition. The
Reaktionsmischung wurde mit Wasser versetzt und mit Dichlormethan extrahiert. Die org. Phasen wurden mit verd. Salzsäure und Wasser gewaschen, getrocknet und die Lösungsmittel abdestilliert. Man erhielt 75.7 g (88% d. Th.) als farbloses Öl.  The reaction mixture was treated with water and extracted with dichloromethane. The org. Phases were washed with dil. Hydrochloric acid and water, dried and the solvents distilled off. 75.7 g (88% of theory) were obtained as a colorless oil.
1H-NMR (400 MHz, CDCIs): δ = 7.90 (d, 1 H), 5.87 (d, 1 H), 4.02 (t, 2H), 1 .73 (pent., 2H), 1 .43 (sext., 2H), 0.94 (t, 3H). 1744.2) 6-[Chlor(difluor)methyl]-2-oxo-1 ,2-dihydropyridin-3-carbonsäuremethylester 1H-NMR (400 MHz, CDCIs): δ = 7.90 (d, 1H), 5.87 (d, 1H), 4.02 (t, 2H), 1 .73 (pent., 2H), 1.43 (sec ., 2H), 0.94 (t, 3H). 1744.2) 6- [chloro (difluoro) methyl] -2-oxo-1,2-dihydropyridine-3-carboxylic acid methyl ester
Unter einer Argonatmosphäre wurde Natrium (7.02 g, 0.31 mol) bei Raumtemperatur in 750 ml Methanol gelöst. Nach Zugabe von (E/Z)-4-Butoxy-1 -chlor-1 ,1 -difluorbut-3- en-2-οη (54.1 g, 0.25 mol) und Methylmalonamat (29.8 g, 41 .4 ml, 0.25 mol) wurde die Reaktionsmischung für 4 h am Rückfluss erhitzt. Nach beendeter Reaktion wurde das Methanol abdestilliert, der Rückstand mit Wasser versetzt und mit Dichlormethan extrahiert. Die wässrige Phase wurde mit verd. Salzsäure auf pH 2 eingestellt, wobei ein Feststoff ausfiel. Nach Absaugen des Feststoffs und Trocknung i. Vak. wurden 42.4 g (70% d. Th.) erhalten. Under an argon atmosphere, sodium (7.02 g, 0.31 mol) was dissolved in 750 ml of methanol at room temperature. After addition of (E / Z) -4-butoxy-1-chloro-1, 1-difluorobut-3-ene-2-one (54.1 g, 0.25 mol) and methylmalonamate (29.8 g, 41.4 ml, 0.25 mol ), the reaction mixture was heated at reflux for 4 h. After completion of the reaction, the methanol was distilled off, the residue was added with water and extracted with dichloromethane. The aqueous phase was adjusted to pH 2 with dilute hydrochloric acid, whereby a solid precipitated. After filtering off the solid and drying i. Vak. 42.4 g (70% of theory) were obtained.
1H-NMR (400 MHz, CDCIs): δ = 12.5 (br.s, 1 H), 8.31 (d, 1 H), 7.38 (d, 2H), 3.85 (s, 3H). 1 H-NMR (400 MHz, CDCIs): δ = 12.5 (br.s, 1H), 8.31 (d, 1H), 7.38 (d, 2H), 3.85 (s, 3H).
1744.3) 5-Chlor-6-[chlor(difluor)methyl]-2-oxo-1 ,2-dihydropyridin-3- carbonsäuremethylester 1744.3) 5-Chloro-6- [chloro (difluoro) methyl] -2-oxo-1,2-dihydropyridine-3-carboxylic acid methyl ester
6-[Chlor(difluor)methyl]-2-oxo-1 ,2-dihydropyridin-3-carbonsäuremethylester (15.0 g, 63.1 mmol) wurde in 750 ml Ν,Ν-Dimethylformamid vorgelegt und portionsweise mit N- Chlorsuccinimid (12.6 g, 94.7 mmol) versetzt. Die Reaktionsmischung wurde für 16 h bei Raumtemperatur gerührt. Nach Zugabe von Wasser wurde der ausgefallene Feststoff abfiltriert und getrocknet. Es wurden 10.6 g (62% d. Th) erhalten. 6- [chloro (difluoro) methyl] -2-oxo-1,2-dihydropyridine-3-carboxylic acid methyl ester (15.0 g, 63.1 mmol) was initially charged in 750 ml of Ν, Ν-dimethylformamide and treated in portions with N-chlorosuccinimide (12.6 g, 94.7 mmol). The reaction mixture was stirred for 16 h at room temperature. After adding water, the precipitated solid was filtered off and dried. 10.6 g (62% of theory) were obtained.
1H-NMR (400 MHz, DMSO-de): δ = 12.7 (br.s, 1 H), 8.35 (s, 1 H), 3.85 (s, 3H). 1H-NMR (400 MHz, DMSO-de): δ = 12.7 (br.s, 1H), 8.35 (s, 1H), 3.85 (s, 3H).
1744.4) 5-Chlor-6-[chlor(difluor)methyl]-2-oxo-1 ,2-dihydropyridin-3-carbonsäure 1744.4) 5-Chloro-6- [chloro (difluoro) methyl] -2-oxo-1,2-dihydropyridine-3-carboxylic acid
5-Chlor-6-[chlor(difluor)methyl]-2-oxo-1 ,2-dihydropyridin-3-carbonsäuremethylester (5.00 g, 18.4 mmol) wurde in 50 ml Methanol gelöst und mit 50 ml einer wässrigen Lösung von Lithiumhydroxid-Monohydrat (1 .16 g, 27.6 mmol) versetzt. Die Methyl 5-chloro-6- [chloro (difluoro) methyl] -2-oxo-1,2-dihydropyridine-3-carboxylate (5.00 g, 18.4 mmol) was dissolved in 50 ml of methanol and treated with 50 ml of an aqueous solution of lithium hydroxide. Monohydrate (1 .16 g, 27.6 mmol) was added. The
Reaktionsmischung wurde für 16 h bei Raumtemperatur nachgerührt. Nachbeendeter Reaktion wurde die Reaktionsmischung unter Eisbadkühlung mit konz. Salzsäure auf pH 1 -2 eingestellt, wobei ein Feststoff ausfiel. Dieser wurde abgesaugt, mit Wasser gewaschen und für 2 h bei 55 °C im Vakuum getrocknet. Es wurden 4.03 g (81 % d. Th.) eines farblosen Feststoffs erhalten. Reaction mixture was stirred for 16 h at room temperature. After completion of the reaction, the reaction mixture under ice bath cooling with conc. Hydrochloric acid adjusted to pH 1-2, wherein a solid precipitated. This was sucked off, with water washed and dried for 2 h at 55 ° C in a vacuum. There was obtained 4.03 g (81% of theory) of a colorless solid.
1H-NMR (400 MHz, DMSO-de): δ = 8.30 (s, 1 H). 1H NMR (400 MHz, DMSO-de): δ = 8.30 (s, 1H).
1744.5) 1 -({5'-chlor-6'-[chlor(difluor)methyl]-2'-oxo-1 ',2'-dihydropyridin-3'-yl}carbonyl)- piperidin-2-carbonsäureethylester 1744.5) 1 - ({5'-chloro-6 '- [chloro (difluoro) methyl] -2'-oxo-1', 2'-dihydropyridin-3'-yl} carbonyl) -piperidine-2-carboxylic acid ethyl ester
5-Chlor-6-[chlor(difluor)methyl]-2-oxo-1 ,2-dihydropyridin-3-carbonsäure (200 mg, 0.78 mmol) wurde in 5 ml THF vorgelegt und mit 1 ,1 -Carbonyldiimidazol (CDI, 251 .0 mg, 1 .55 mmol) versetzt. Die Reaktionsmischung wurde für 1 h bei Raumtemperatur gerührt. Nach Zugabe von Piperidin-2-carbonsäureethylester (244.0 mg, 1 .55 mmol) wurde die Mischung für 16 h bei Raumtemperatur gerührt. Nach Zugabe Wasser wurde die Mischung mit Essigsäureethylester extrahiert und die organischen Phasen getrocknet. Nach Entfernen der Lösungsmittel i. Vak. und saulenchromatographischer Reinigung wurden 59.0 mg (19% d. Th.) eines farblosen Feststoffs erhalten. 5-Chloro-6- [chloro (difluoro) methyl] -2-oxo-1,2-dihydropyridine-3-carboxylic acid (200 mg, 0.78 mmol) was initially charged in 5 ml THF and treated with 1, 1-carbonyldiimidazole (CDI, 251 .0 mg, 1 .55 mmol). The reaction mixture was stirred for 1 h at room temperature. After addition of piperidine-2-carboxylic acid ethyl ester (244.0 mg, 1 .55 mmol), the mixture was stirred for 16 h at room temperature. After adding water, the mixture was extracted with ethyl acetate and the organic phases were dried. After removal of the solvents i. Vak. and column chromatography, 59.0 mg (19% of theory) of a colorless solid were obtained.
1H-NMR (400 MHz, DMSO-de): δ = 12.6 (s, 1 H), 7.93 (s, 1 H), 5.26 - 5.20 (m, 1 H), 4.22 - 4.13 (m, 2H), 3.20 - 3.10 (m, 1 H), 2.48 - 2.43 (m, 1 H), 2.21 - 2.12 (m, 1 H), 1 .74 - 1 .60 (m, 4H), 146 - 1 .35 (m, 1 H), 1 .23 (t, 3H). 1H NMR (400 MHz, DMSO-de): δ = 12.6 (s, 1H), 7.93 (s, 1H), 5.26-5.20 (m, 1H), 4.22-4.13 (m, 2H), 3.20 - 3.10 (m, 1H), 2.48 - 2.43 (m, 1H), 2.21 - 2.12 (m, 1H), 1 .74 - 1 .60 (m, 4H), 146 - 1 .35 (m, 1 H), 1 .23 (t, 3H).
In der nachfolgenden Tabelle A sind beispielhaft eine Reihe weiterer Verbindungen der allgemeinen Formel (I) aufgeführt, die in analoger Weise zu den obigen Beispielen und den weiter oben erwähnten Methoden erhalten werden können. Table A below lists by way of example a series of further compounds of the general formula (I) which can be obtained analogously to the above examples and the methods mentioned above.
In der Tabelle bedeuten: In the table mean:
Bu = Butyl Et = Ethyl  Bu = butyl Et = ethyl
Me = Methyl Ph = Phenyl  Me = methyl Ph = phenyl
Pr = Propyl Pr = propyl
i = iso s = sekundär i = iso s = secondary
t = tertiär c = cyclo Entsprechendes gilt für die zusammengesetzten Ausdrücke wie t = tertiary c = cyclo The same applies to the compound expressions such as
iPr = Isopropyl iPr = isopropyl
iBu = Isobutyl iBu = isobutyl
sBu = sec.-Butyl sBu = sec-butyl
tBu = tert.-Butyl tBu = tert-butyl
cPr = Cyclopropyl cPr = cyclopropyl
cPentyl = Cyclopentyl cpentyl = cyclopentyl
cHexyl = Cyclohexyl Ist in Tabelle A ein Alkylrest ohne weitere Kennzeichnung aufgeführt, so handelt es sich um den geradkettigen Alkylrest, d. h. beispielsweise Bu = n-Bu = n-Butyl. cHexyl = cyclohexyl If an alkyl radical without further labeling is listed in Table A, then it is the straight-chain alkyl radical, ie. H. for example, Bu = n-Bu = n-butyl.
Die Zahlenindizes in den Formelausdrücken sind in Tabelle A nicht tiefgestellt, sondern in derselben Zeilenhöhe und Schriftgröße wie die Atomsymbole angeordnet. The numeric indices in the formula expressions are not subscripted in Table A, but arranged in the same row height and font size as the atomic symbols.
Beispielsweise entspricht die Formel CF3 in der Tabelle der Formel CF3 gemäß üblicher Schreibweise mit tiefgestelltem Index oder die Formel CH2CH(CH2CH3)2 der Formel CH2CH(CH2CH3)2 mit tiefgestellten Indices. For example, the formula CF 3 in the table is of the formula CF3 according to conventional notation subscripted or the formula CH 2 CH (CH2CH3) 2 of the formula CH 2 CH (CH 2 CH 3) 2 with subscripts.
Tabelle A: Verbindungen der Formel (I) Table A: Compounds of the formula (I)
NMR-Daten ausgewählter in obiger Tabelle A genannter Verbindungen Die NMR-Daten ausgewählter, in Tabelle A genannter Verbindungen werden entweder in klassischer Form (δ-Werte, Anzahl der H-Atome, Multiplettaufspaltung) oder als NMR-Peak-Listen aufgeführt. Die Zuordnung der in Tabelle A genannten NMR data of selected compounds mentioned in Table A above. The NMR data of selected compounds listed in Table A are listed either in classical form (δ values, number of H atoms, multiplet splitting) or as NMR peak lists. The assignment of the mentioned in Table A.
Verbindungen erfolgt über die Beispielnummern gemäß Tabelle A. Connections are made using the example numbers according to Table A.
Wenn die 1H-NMR-Daten ausgewählter Beispiele in Form von 1H-NMR-Peaklisten notiert werden, wird zu jedem Signalpeak erst der δ-Wert in ppm und dann die When the 1 H-NMR data of selected examples are noted in the form of 1 H-NMR peak lists, the δ-value in ppm and then the
Signalintensität in runden Klammern aufgeführt. Die δ-Wert - Signal intensitäts- Zahlenpaare von verschiedenen Signalpeaks werden durch Semikolons voneinander getrennt aufgelistet. Die Peakliste hat daher die nachfolgend dargestellte Form: δι (Intensitäti); 82 (lntensität.2); ; δ, (Intensität,'; ; δη (lntensitätn) Signal intensity listed in parentheses. The δ-value-signal intensity-number pairs of different signal peaks are listed separated by semicolons. The peak list therefore has the following form: δι (intensity i); 82 (intensity.2); ; δ, (intensity, ';; δ η (intensity n )
Die Intensität scharfer Signale korreliert mit der Höhe der Signale in einem gedruckten Beispiel eines NMR-Spektrums in cm und zeigt die wirklichen Verhältnisse der Signalintensitäten. Bei breiten Signalen können mehrere Peaks oder die Mitte des Signals und ihre relative Intensität im Vergleich zum intensivsten Signal im Spektrum gezeigt werden. The intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. For broad signals, multiple peaks or the center of the signal and their relative intensity can be shown compared to the most intense signal in the spectrum.
Zur Kalibrierung der chemischen Verschiebung von 1H-NMR-Spektren wirf To calibrate the chemical shift of 1 H NMR spectra wirf
Tetramethylsilan und/oder die chemische Verschiebung des Lösungsmittels benutzt, besonders im Falle von Spektren, die in DMSO gemessen werden. Daher kann in NMR-Peaklisten der Tetramethylsilan-Peak vorkommen, muss es aber nicht. Tetramethylsilane and / or the chemical shift of the solvent used, especially in the case of spectra, which are measured in DMSO. Therefore, the tetramethylsilane peak can occur in NMR peaks, but it does not have to.
Die Listen der 1H-NMR-Peaks sind ähnlich den klassischen 1H-NMR-Ausdrucken und enthalten somit gewöhnlich alle Peaks, die bei einer klassischen NMR- Interpretation aufgeführt werden. The lists of 1 H NMR peaks are similar to the classical 1 H NMR prints and thus usually contain all the peaks listed in a classical NMR interpretation.
Darüber hinaus können sie wie klassische 1H-NMR-Ausdrucke Lösungsmittelsignale, Signale von Stereoisomeren der Zielverbindungen, die ebenfalls Gegenstand der Erfindung sind, und/oder Peaks von Verunreinigungen zeigen. Bei der Angabe von Verbindungssignalen im Delta-Bereich von Lösungsmitteln und/oder Wasser sind in den Listen von 1H-NMR-Peaks die gewöhnlichen Moreover, like classical 1 H NMR prints, they can show solvent signals, signals from stereoisomers of the target compounds, which are also the subject of the invention, and / or peaks of impurities. When indicating connection signals in the delta range of solvents and / or water, the lists of 1 H NMR peaks are the usual ones
Lösungsmittelpeaks, zum Beispiel Peaks von DMSO in DMSO- und der Peak von Wasser, gezeigt, die gewöhnlich im Durchschnitt eine hohe Intensität aufweisen. Die Peaks von Stereoisomeren der Targetverbindungen und/oder Peaks von Solvent peaks, for example peaks of DMSO in DMSO- and the peak of water, which are usually of high intensity on average. The peaks of stereoisomers of the target compounds and / or peaks of
Verunreinigungen haben gewöhnlich im Durchschnitt eine geringere Intensität als die Peaks der Zielverbindungen (zum Beispiel mit einer Reinheit von >90%). Impurities usually have on average a lower intensity than the peaks of the target compounds (for example with a purity of> 90%).
Solche Stereoisomere und/oder Verunreinigungen können typisch für das jeweilige Herstellungsverfahren sein. Ihre Peaks können somit dabei helfen, die Reproduktion unseres Herstellungsverfahrens anhand von "Nebenprodukt-Fingerabdrucken" zu erkennen. Such stereoisomers and / or impurities may be typical of the particular preparation process. Their peaks can thus help the reproduction of our manufacturing process by "by-product fingerprints".
Ein Fachmann, der die Peaks der Zielverbindungen mit bekannten Verfahren A person skilled in the art, the peaks of the target compounds by known methods
(MestreC, ACD-Simulation, aber auch mit empirisch ausgewerteten Erwartungswerten) berechnet, kann je nach Bedarf die Peaks der Zielverbindungen isolieren, wobei gegebenenfalls zusätzliche Intensitätsfilter eingesetzt werden. Diese Isolierung ist ähnlich dem betreffenden Peak-Picking bei der klassischen 1H-NMR-lnterpretation gegeben. (MestreC, ACD simulation, but also with empirically evaluated expected values), can isolate the peaks of the target compounds as needed, using additional intensity filters if necessary. This isolation is similar to peak picking in the classical 1 H NMR interpretation.
Verbindung Nr. 1212, Lösungsmittel: [DMSO], 400 MHz Compound No. 1212, solvent: [DMSO], 400 MHz
8,7623 (2,03); 8,434 (12,64); 8,433 (13,22); 7,1577 (0,37); 3,3649 (3,75); 3,3507 (5,06); 3,3469 (9,73); 3,3329 (10,53); 3,3289 (10,54); 3,3191 (4,46); 3,3148 (9,66); 3,31 1 (4,89); 3,301 1 (2,24); 3,2968 (3,67); 2,8418 (0,53); 2,8273 (0,55); 2,8236 (0,53); 2,8091 (0,53); 2,673 (0,31 ); 2,5266 (0,53); 2,5219 (0,73); 2,5132 (15,56); 2,5086 8.7623 (2.03); 8,434 (12,64); 8,433 (13,22); 7.1577 (0.37); 3.3649 (3.75); 3,3507 (5,06); 3.3469 (9.73); 3,3329 (10,53); 3,3289 (10,54); 3,3191 (4,46); 3,3148 (9,66); 3.31 1 (4.89); 3.301 1 (2.24); 3,2968 (3,67); 2.8418 (0.53); 2.8273 (0.55); 2.8236 (0.53); 2.8091 (0.53); 2,673 (0.31); 2.5266 (0.53); 2.5219 (0.73); 2,5132 (15.56); 2.5086
(35,14); 2,504 (50); 2,4994 (35,33); 2,4948 (15,84); 2,0873 (1 ,5); 2,0752 (0,57); 1 ,2806 (0,31 ); 1 ,1984 (0,47); 1 ,195 (0,31 ); 1 ,1601 (2,01 ); 1 ,1529 (16,88); 1 ,142 (4,22); 1 ,1349 (36,51 ); 1 ,1238 (2,23); 1 ,1 168 (16,39); 0,6742 (0,35); -0,0002 (5,99); Verbindung Nr. 2202, Lösungsmittel: [DMSO], 400 MHz (35.14); 2,504 (50); 2.4994 (35.33); 2,4948 (15,84); 2.0873 (1, 5); 2.0752 (0.57); 1, 2806 (0.31); 1, 1984 (0.47); 1, 195 (0.31); 1, 1601 (2.01); 1, 1529 (16,88); 1, 142 (4,22); 1, 1349 (36, 51); 1, 1238 (2.23); 1, 168 (16, 39); 0.6742 (0.35); -0,0002 (5.99); Compound No. 2202, solvent: [DMSO], 400 MHz
13,4417 (0,37); 9,0046 (0,5); 8,4124 (8,33); 7,206 (5,24); 7,0745 (13,79); 6,9429 (6,22); 3,4828 (0,56); 3,3619 (2,96); 3,3477 (3,4); 3,3439 (9,47); 3,3297 (9,62); 3,3258 (10,14); 3,31 17 (9,62); 3,3079 (3,94); 3,2937 (3,16); 2,5138 (1 1 ,84); 2,5092 (28,43); 2,5046 (41 ,41 ); 2,5 (30,07); 2,4953 (13,75); 1 ,1466 (22); 1 ,1286 (50); 1 ,1 105 (21 ,47); - 0,0002 (7,09);  13, 4417 (0.37); 9.0046 (0.5); 8.4124 (8.33); 7,206 (5:24); 7.0745 (13.79); 6,9429 (6,22); 3.4828 (0.56); 3.3619 (2.96); 3.3477 (3.4); 3.3439 (9.47); 3,3297 (9,62); 3,3258 (10,14); 3.31 17 (9.62); 3,3079 (3,94); 3,2937 (3,16); 2,5138 (1 1, 84); 2.5092 (28.43); 2.5046 (41, 41); 2.5 (30.07); 2.4953 (13.75); 1, 1466 (22); 1, 1286 (50); 1, 1 105 (21, 47); - 0.0002 (7.09);
Verbindung Nr. 2209, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2209, solvent: [CDCl3], 400 MHz
8,8346 (0,69); 8,6969 (8,07); 7,2663 (0,34); 7,262 (46,18); 5,3002 (2,24); 4,302 (0,56); 4,2856 (1 ,55); 4,2691 (2,23); 4,2663 (1 ,8); 4,2526 (1 ,81 ); 4,2498 (2,27); 4,2334 (1 ,68); 4,2171 (0,64); 1 ,2632 (50); 1 ,2467 (49,93); 0,921 1 (0,33); 0,0697 (0,52); 0,0081 (0,58); -0,0002 (23,9); -0,0085 (0,78); Verbindung Nr.2223, Lösungsmittel: [DMSO], 400 MHz 8.8346 (0.69); 8,6969 (8.07); 7.2663 (0.34); 7.262 (46.18); 5,3002 (2.24); 4.302 (0.56); 4,2856 (1, 55); 4,2691 (2.23); 4,2663 (1, 8); 4,2526 (1, 81); 4,2498 (2.27); 4,2334 (1, 68); 4.2171 (0.64); 1, 2632 (50); 1, 2467 (49.93); 0.921 1 (0.33); 0.0697 (0.52); 0.0081 (0.58); -0.0002 (23.9); -0.0085 (0.78); Compound No. 2223, solvent: [DMSO], 400 MHz
8,6658 (4,79); 8,6259 (0,75); 3,3465 (8,69); 3,1458 (4,55); 3,1302 (4,53); 2,6728 (0,3); 2,555 (0,31); 2,5131 (16,61); 2,5086 (36,23); 2,5041 (50); 2,4996 (35,61); 2,4951 (16,09); 2,4534 (0,32); 2,0875 (3,81); 0,955 (0,4); 0,9451 (4,23); 0,904 (49,74); 0,8532 (0,37); -0,0002 (3,76);  8,6658 (4.79); 8,6259 (0.75); 3.3465 (8.69); 3,1458 (4,55); 3,1302 (4,53); 2.6728 (0.3); 2,555 (0.31); 2.5131 (16.61); 2,5086 (36,23); 2,5041 (50); 2.4996 (35.61); 2.4951 (16.09); 2.4534 (0.32); 2.0875 (3.81); 0.955 (0.4); 0.9451 (4.23); 0.904 (49.74); 0.8532 (0.37); -0,0002 (3.76);
Verbindung Nr.1565, Lösungsmittel: [DMSO], 400 MHz Compound No. 1565, solvent: [DMSO], 400 MHz
8,8649 (1,47); 8,851 (2,71); 8,8375 (1,59); 8,3737 (13,08); 5,9356 (0,79); 5,9226 (1,74); 5,9098 (1,67); 5,8968 (2,07); 5,8817 (1,9); 5,8797 (2,16); 5,8668 (1,91); 5,8538 (2,13); 5,841 (1 ,01 ); 5,2502 (3,77); 5,2484 (3,81 ); 5,2462 (3,79); 5,2071 (3,33); 5,2053 8.8649 (1.47); 8,851 (2.71); 8.8375 (1.59); 8,3737 (13.08); 5.9356 (0.79); 5.9226 (1.74); 5.9098 (1.67); 5.8968 (2.07); 5.8817 (1.9); 5,8797 (2,16); 5.8668 (1.91); 5.8538 (2.13); 5,841 (1, 01); 5.2502 (3.77); 5.2484 (3.81); 5.2462 (3.79); 5,2071 (3,33); 5.2053
(3.36) ; 5,2031 (3,34); 5,1354 (4,06); 5,1317 (3,83); 5,1097 (3,81); 5,1083 (3,71); (3.36); 5,2031 (3,34); 5.1354 (4.06); 5.1317 (3.83); 5.1097 (3.81); 5,1083 (3.71);
5,1059 (3,62); 3,9556 (4,13); 3,9427 (7,68); 3,9284 (4,13); 3,9109 (0,84); 3,3412 (22,6); 2,6734 (0,32); 2,5066 (46,89); 2,5047 (50); 2,0767 (0,77); 2,0746 (1,11); 1,234 (0,49); 0,0019 (0,84); -0,0002 (1,09); 5,1059 (3.62); 3.9556 (4.13); 3.9427 (7.68); 3.9284 (4.13); 3.9109 (0.84); 3.3412 (22.6); 2.6734 (0.32); 2.5066 (46.89); 2,5047 (50); 2.0767 (0.77); 2.0746 (1.11); 1,234 (0.49); 0.0019 (0.84); -0.0002 (1.09);
Verbindung Nr.2224, Lösungsmittel: [DMSO], 400 MHz Compound No. 2224, solvent: [DMSO], 400 MHz
9,0276 (0,38); 9,0137 (0,77); 8,9996 (0,41); 8,7018 (2,82); 8,5105 (0,81); 4,1208 (2,6); 4,1066 (2,6); 3,837 (0,31); 3,6645 (10,33); 3,4379 (6,63); 2,6718 (0,34); 2,5023 (50); 2,0729 (0,43); 1,356 (1,07); 0,0017 (4,72); -0,0002 (4,79);  9.0276 (0.38); 9.0137 (0.77); 8.9996 (0.41); 8,7018 (2,82); 8.5105 (0.81); 4,1208 (2,6); 4.1066 (2.6); 3,837 (0.31); 3.6645 (10.33); 3.4379 (6.63); 2.6718 (0.34); 2.5023 (50); 2.0729 (0.43); 1.356 (1.07); 0.0017 (4.72); -0.0002 (4.79);
Verbindung Nr.2225, Lösungsmittel: [DMSO], 400 MHz Compound No. 2225, solvent: [DMSO], 400 MHz
8,6055 (3,29); 3,9028 (0,93); 3,8857 (1,08); 3,8798 (0,99); 3,8626 (0,92); 3,3173 8,6055 (3,29); 3.9028 (0.93); 3.8857 (1.08); 3.8798 (0.99); 3.8626 (0.92); 3.3173
(7.37) ; 2,5057 (35,73); 2,5018 (50); 2,4975 (37,71); 2,0738 (1,06); 1,3553 (0,47); (7.37); 2,5057 (35,73); 2.5018 (50); 2.4975 (37.71); 2.0738 (1.06); 1.3573 (0.47);
1,2334 (0,61); 1,0762 (8,19); 1,0592 (8,18); 0,8972 (45,37); 0,8579 (0,53); 0,8484 (0,42); -0,0002 (5,77); -0,0017 (4,97); 1.2334 (0.61); 1.0762 (8.19); 1.0592 (8.18); 0.8972 (45.37); 0.8579 (0.53); 0.8484 (0.42); -0.0002 (5.77); -0.0017 (4.97);
Verbindung Nr.1679, Lösungsmittel: [DMSO], 400 MHz Compound No. 1679, solvent: [DMSO], 400 MHz
8,3725 (0,53); 3,6269 (50); 2,5107 (2,79); 2,5075 (3,65); 2,5036 (2,74); 1,5003 (0,32); 1,1429 (0,91); 1,1264 (0,9); 0,884 (0,46); 0,8656 (0,92); 0,847 (0,4);  8.3725 (0.53); 3,6269 (50); 2.5107 (2.79); 2.5075 (3.65); 2.5036 (2.74); 1,5003 (0.32); 1.1429 (0.91); 1.1264 (0.9); 0.884 (0.46); 0.8656 (0.92); 0.847 (0.4);
Verbindung Nr.1688, Lösungsmittel: [DMSO], 400 MHz Compound No. 1688, solvent: [DMSO], 400 MHz
8,4737 (1,39); 8,4531 (1,41); 8,3891 (8,91); 3,8839 (0,99); 3,8676 (1,63); 3,8467 (1,61); 3,8304 (1); 3,3364 (6,91); 2,5428 (0,32); 2,5072 (36,58); 2,5032 (50); 2,499 (37,24); 2,3298 (0,32); 2,0747 (0,45); 1,7996 (0,4); 1,7828 (1,15); 1,7662 (1,95); 1 ,7495 (1 ,99); 1 ,7331 (1 ,23); 1 ,7161 (0,45); 1 ,1126 (13,68); 1 ,0958 (13,57); 0,9013 (22,11); 0,8843 (21,5); -0,0002 (5,66); -0,0015 (5,39); 8.4737 (1.39); 8.4531 (1.41); 8,3891 (8.91); 3.8839 (0.99); 3.8676 (1.63); 3.8467 (1.61); 3.8304 (1); 3.3364 (6.91); 2.5428 (0.32); 2.5072 (36.58); 2.5032 (50); 2,499 (37.24); 2.3298 (0.32); 2.0747 (0.45); 1.7996 (0.4); 1.7828 (1.15); 1.7662 (1.95); 1, 7495 (1, 99); 1, 7331 (1, 23); 1, 7161 (0.45); 1, 1126 (13.68); 1, 0958 (13.57); 0.9013 (22.11); 0.8843 (21.5); -0,0002 (5.66); -0.0015 (5.39);
Verbindung Nr.2001, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2001, solvent: [CDCl3], 400 MHz
8,5005 (6,96); 8,118 (0,35); 7,2608 (50); 3,3225 (5,44); 3,3074 (6,42); 3,3056 (6,96); 3,2904 (5,61); 2,009 (0,74); 1,9488 (0,91); 1,932 (1,84); 1,9151 (2,33); 1,8983 (1,9); 1,8815 (0,99); 1,8647 (0,31); 1,0717 (0,76); 1,0549 (0,72); 0,9931 (37,46); 0,9764 (36,24); 0,008 (0,67); -0,0002 (25,44); -0,0085 (0,68); Verbindung Nr.2007, Lösungsmittel: [CDCI3], 400 MHz 8,5005 (6.96); 8.118 (0.35); 7.2608 (50); 3.3225 (5.44); 3,3074 (6,42); 3,3056 (6,96); 3,2904 (5.61); 2,009 (0.74); 1.9488 (0.91); 1,932 (1.84); 1.9151 (2.33); 1.8983 (1.9); 1.8815 (0.99); 1.8647 (0.31); 1.0717 (0.76); 1.0549 (0.72); 0.9931 (37.46); 0.9764 (36.24); 0.008 (0.67); -0,0002 (25,44); -0.0085 (0.68); Compound No. 2007, solvent: [CDCl3], 400 MHz
8,5485 (10,65); 8,2909 (0,56); 7,2608 (50); 4,9202 (5,67); 4,9173 (10,78); 4,9142 (10,55); 4,9112 (5,67); 4,0378 (5,8); 4,023 (5,79); 2,0089 (6,04); 1,8713 (0,39); 1,7932 (20,42); 0,9913 (1,15); 0,9745 (1,11); 0,008 (0,59); -0,0002 (25,86); -0,0085 (0,77); Verbindung Nr.2009, Lösungsmittel: [CDCI3], 400 MHz  8.5485 (10.65); 8.2909 (0.56); 7.2608 (50); 4.9202 (5.67); 4.9173 (10.78); 4.9142 (10.55); 4.9112 (5.67); 4.0378 (5.8); 4.023 (5.79); 2,0089 (6.04); 1.8713 (0.39); 1.7932 (20.42); 0.9913 (1.15); 0.9745 (1.11); 0.008 (0.59); -0,0002 (25,86); -0.0085 (0.77); Compound No. 2009, solvent: [CDCl3], 400 MHz
8,4585 (5,62); 7,7568 (0,34); 7,3115 (0,74); 7,2608 (50); 7,2108 (1,19); 4,1531 (0,68); 4,1365 (1,48); 4,1197 (1,68); 4,1159 (1,53); 4,0993 (1,48); 4,0827 (0,72); 2,0089 (0,47); 1 ,6682 (0,31 ); 1 ,6505 (0,35); 1 ,6352 (1 ,24); 1 ,6166 (4,09); 1 ,5993 (5,66); 1 ,581 (4,61); 1,5627 (1,48); 1,3992 (0,42); 1,383 (0,4); 1,3071 (0,36); 1,256 (15,88); 1,2395 (15,64); 1 ,2058 (0,45); 1 ,1893 (0,44); 1 ,0382 (0,47); 1 ,0151 (0,33); 0,9826 (7,57); 0,9641 (15,59); 0,9454 (6,85); 0,9139 (0,43); 0,0504 (0,32); 0,0079 (0,68); -0,0002 (21,18); -0,0086 (0,75); -0,0503 (0,5);  8,4585 (5,62); 7.7568 (0.34); 7.3115 (0.74); 7.2608 (50); 7.2108 (1.19); 4.1531 (0.68); 4.1365 (1.48); 4.1197 (1.68); 4.1159 (1.53); 4.0993 (1.48); 4.0827 (0.72); 2,0089 (0.47); 1, 6682 (0.31); 1, 6505 (0.35); 1, 6352 (1, 24); 1, 6166 (4.09); 1, 5993 (5.66); 1, 581 (4.61); 1.5627 (1.48); 1.3992 (0.42); 1.383 (0.4); 1.3071 (0.36); 1,256 (15,88); 1.2395 (15.64); 1, 2058 (0.45); 1, 1893 (0.44); 1, 0382 (0.47); 1, 0151 (0.33); 0.9826 (7.57); 0.9641 (15.59); 0.9454 (6.85); 0.9139 (0.43); 0.0504 (0.32); 0.0079 (0.68); -0.0002 (21.18); -0.0086 (0.75); -0.0503 (0.5);
Verbindung Nr.2016, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2016, solvent: [CDCl3], 400 MHz
8,4341 (7,93); 7,6601 (2,26); 7,3047 (18,35); 7,2858 (24,53); 7,2606 (50); 5,2997 (3,97); 4,2928 (5,23); 1,6585(8,93); 1,511 (9,14); 1,3936 (8,21); 1,2486 (25,99); 8,4341 (7.93); 7.6601 (2.26); 7,3047 (18,35); 7.2858 (24.53); 7.2606 (50); 5.2997 (3.97); 4,2928 (5,23); 1.6585 (8.93); 1,511 (9,14); 1.3936 (8.21); 1.2486 (25.99);
1,2325 (18,68); 0,9459 (49,4); 0,9328 (34,96); -0,0002 (28,64); 1.2325 (18.68); 0.9459 (49.4); 0.9328 (34.96); -0.0002 (28.64);
Verbindung Nr.2020, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2020, solvent: [CDCl3], 400 MHz
0,146 (0,45); 0,0502 (0,54); 0,011 (0,57); 0,0101 (0,66); 0,0093 (0,9); 0,0082 (4,03); 0,0069 (1,59); 0,0061 (1,83); 0,0053 (1,43); 0,0044 (1,48); 0,0036 (2,31); 0,0028 (4,61); 0,0019 (7,29); 0 (179,38); -0,0019 (45,97); -0,0048 (2,9); -0,0057 (2,05); - 0,0065 (1,71); -0,0083 (5,22); -0,1496 (0,5); Verbindung Nr. 2023, Lösungsmittel: [CDCI3], 400 MHz 0.146 (0.45); 0.0502 (0.54); 0.011 (0.57); 0.0101 (0.66); 0.0093 (0.9); 0.0082 (4.03); 0.0069 (1.59); 0.0061 (1.83); 0.0053 (1.43); 0.0044 (1.48); 0.0036 (2.31); 0.0028 (4.61); 0.0019 (7.29); 0 (179.38); -0.0019 (45.97); -0.0048 (2.9); -0.0057 (2.05); - 0.0065 (1.71); -0.0083 (5.22); -0.1496 (0.5); Compound No. 2023, solvent: [CDCl3], 400 MHz
8,4635 (5,14); 8,0225 (0,4); 7,2625 (14,19); 4,5184 (1 ,49); 4,5059 (3,37); 4,4934 (1 ,53); 3,6466 (2,71 ); 3,6325 (3,88); 3,6195 (2,47); 3,4415 (50); 3,3907 (0,37); 3,3893 (0,39); 2,0107 (1 ,38); -0,0002 (7,96);  8,4635 (5:14); 8.0225 (0.4); 7,2625 (14:19); 4,5184 (1, 49); 4,5059 (3.37); 4,4934 (1, 53); 3.6466 (2.71); 3.6325 (3.88); 3.6195 (2.47); 3,4415 (50); 3,3907 (0.37); 3,3893 (0.39); 2,0107 (1, 38); -0,0002 (7,96);
Verbindung Nr. 1755, Lösungsmittel: [DMSO], 400 MHz Compound No. 1755, solvent: [DMSO], 400 MHz
12,5538 (1 ,28); 8,1739 (0,53); 8,0175 (8,7); 3,6181 (0,6); 3,6015 (1 ,23); 3,5954 (0,64); 3,5851 (0,77); 3,4502 (2,44); 3,001 (1 ,04); 2,971 1 (30,1 1 ); 2,8456 (1 ,14); 2,8285 (31 ,56); 2,8078 (0,42); 2,6713 (0,31 ); 2,5247 (0,6); 2,5201 (0,81 ); 2,51 12 (15,67);  12.5538 (1, 28); 8.1739 (0.53); 8.0175 (8.7); 3.6181 (0.6); 3,6015 (1, 23); 3.5954 (0.64); 3.5851 (0.77); 3,4502 (2.44); 3,001 (1, 04); 2,971 1 (30.1 1); 2.8456 (1, 14); 2,8285 (31,56); 2.8078 (0.42); 2.6713 (0.31); 2.5247 (0.6); 2.5201 (0.81); 2.51 12 (15.67);
2,5067 (35,26); 2,5022 (50); 2,4976 (35,64); 2,493 (16,2); 2,0736 (1 ,04); 1 ,7767 (0,37); 1 ,7689 (0,39); 1 ,7601 (1 ,15); 1 ,7514 (0,4); 1 ,7437 (0,4); 1 ,3558 (0,98); -0,0002 (3,81 ); 2,5067 (35,26); 2,5022 (50); 2.4976 (35.64); 2,493 (16.2); 2,0736 (1, 04); 1, 7767 (0.37); 1, 7689 (0.39); 1, 7601 (1, 15); 1, 7514 (0.4); 1, 7437 (0.4); 1, 3558 (0.98); -0.0002 (3.81);
Verbindung Nr. 1269, Lösungsmittel: [DMSO], 400 MHz Compound No. 1269, solvent: [DMSO], 400 MHz
9,031 1 (0,45); 9,017 (0,87); 9,0026 (0,46); 8,4052 (3,78); 8,4038 (4,12); 4,6207 (0,6); 4,2824 (0,68); 4,1307 (4,33); 4,1226 (1 ,01 ); 4,1 163 (4,33); 3,85 (0,32); 3,7271 (0,47); 3,6793 (1 ,69); 3,6666 (21 ,41 ); 3,3406 (4,06); 2,6708 (0,31 ); 2,5243 (0,62); 2,5196 (0,85); 2,5108 (15,64); 2,5063 (35,39); 2,5017 (50); 2,497 (35,26); 2,4924 (15,57); 2,0732 (1 ,41 ); 1 ,3556 (1 ,89); -0,0002 (4,95); Verbindung Nr. 2085, Lösungsmittel: [CDCI3], 400 MHz  9.031 1 (0.45); 9.017 (0.87); 9.0026 (0.46); 8,4052 (3.78); 8,4038 (4,12); 4.6207 (0.6); 4.2824 (0.68); 4,1307 (4,33); 4,1226 (1, 01); 4.1163 (4.33); 3.85 (0.32); 3.7271 (0.47); 3,6793 (1,669); 3,6666 (21, 41); 3,3406 (4.06); 2.6708 (0.31); 2.5243 (0.62); 2.5196 (0.85); 2,5108 (15,64); 2,5063 (35,39); 2.5017 (50); 2,497 (35,26); 2,4924 (15.57); 2.0732 (1, 41); 1, 3556 (1, 89); -0,0002 (4,95); Compound No. 2085, solvent: [CDCl3], 400 MHz
7,9751 (5,08); 7,2659 (0,33); 7,2651 (0,37); 7,2642 (0,55); 7,2634 (0,89); 7,2603 (50); 7,2567 (1 ); 7,2558 (0,73); 7,255 (0,53); 7,2542 (0,36); 3,1275 (29,16); 1 ,5851 (1 ,02); 0,0079 (0,5); -0,0002 (18,81 ); -0,0083 (0,57); Verbindung Nr. 1988, Lösungsmittel: [CDCI3], 400 MHz  7,9751 (5.08); 7.2659 (0.33); 7.2651 (0.37); 7.2642 (0.55); 7.2634 (0.89); 7.2603 (50); 7.2567 (1); 7.2558 (0.73); 7.255 (0.53); 7.2542 (0.36); 3,1275 (29,16); 1, 5851 (1, 02); 0.0079 (0.5); -0,0002 (18,81); -0.0083 (0.57); Compound No. 1988, solvent: [CDCl3], 400 MHz
8,3303 (0,95); 7,5185 (0,31 ); 7,2598 (50); 2,0062 (0,33); 1 ,5742 (0,43); 1 ,5531 (0,45); 1 ,474 (28,84); 1 ,3148 (0,32); 0,8819 (0,37); 0,008 (0,58); -0,0002 (22,15); -0,0085 (0,66); Verbindung Nr. 1687, Lösungsmittel: [CDCI3], 400 MHz  8,3303 (0.95); 7.5185 (0.31); 7,2598 (50); 2.0062 (0.33); 1, 5742 (0.43); 1, 5531 (0.45); 1, 474 (28,84); 1, 3148 (0.32); 0.8819 (0.37); 0.008 (0.58); -0.0002 (22.15); -0.0085 (0.66); Compound No. 1687, solvent: [CDCl3], 400 MHz
9,0593 (0,64); 9,0378 (0,67); 8,6077 (3,78); 7,2647 (0,48); 7,2615 (33,25); 7,2571 (0,65); 7,2563 (0,47); 7,2554 (0,37); 4,1269 (0,3); 4,1 1 (1 ,01 ); 4,0929 (1 ,12); 4,0862 (1 ,13); 4,0691 (1 ,04); 4,052 (0,34); 1 ,3213 (0,41 ); 1 ,3039 (0,8); 1 ,2866 (1 ); 1 ,2642 (3,74); 1 ,1826 (8,34); 1 ,1656 (8,33); 1 ,1 185 (0,35); 1 ,0138 (0,32); 0,9656 (50); 0,9256 (1,04); 0,8987 (2,23); 0,8879 (1,24); 0,882 (6,95); 0,8642 (2,84); 0,8484 (0,39); 0,8369 (0,31); 0,8076 (0,38); 0,0081 (0,43); -0,0002 (18,19); -0,0014 (7,13); -0,0085 (0,55); 9.0593 (0.64); 9.0378 (0.67); 8.6077 (3.78); 7.2647 (0.48); 7,2615 (33,25); 7.2571 (0.65); 7.2563 (0.47); 7.2554 (0.37); 4.1269 (0.3); 4.1 1 (1, 01); 4.0929 (1, 12); 4.0862 (1, 13); 4,0691 (1, 04); 4.052 (0.34); 1, 3213 (0.41); 1, 3039 (0.8); 1, 2866 (1); 1, 2642 (3.74); 1, 1826 (8.34); 1, 1656 (8.33); 1, 185 (0.35); 1, 0138 (0.32); 0.9656 (50); 0.9256 (1.04); 0.8987 (2.23); 0.8879 (1.24); 0.882 (6.95); 0.8642 (2.84); 0.8484 (0.39); 0.8369 (0.31); 0.8076 (0.38); 0.0081 (0.43); -0,0002 (18:19); -0.0014 (7.13); -0.0085 (0.55);
Verbindung Nr.1883, Lösungsmittel: [CDCI3], 400 MHz Compound No. 1883, solvent: [CDCl3], 400 MHz
9,0338 (0,93); 8,655 (7,86); 7,2629 (50); 6,5319 (0,55); 6,5199 (1,16); 6,5077 (0,58); 6,4001 (1,15); 6,388 (2,43); 6,3758 (1,22); 6,268 (0,57); 6,256 (1,24); 6,2438 (0,64); 3,3392 (5,33); 3,3255 (5,78); 3,3214 (6,05); 3,3077 (5,49); 2,1185 (5,02); 2,048 (0,94); 2,0114 (0,44); 1,2786 (0,39); 1,2607 (0,77); 1,2534 (0,74); 1,2428 (0,38); 1,1001 (0,41); 1,0925 (0,57); 1,0804 (1,15); 1,0741 (0,98); 1,0703 (0,77); 1,0622 (1,92); 9.0338 (0.93); 8,655 (7.86); 7,2629 (50); 6.5319 (0.55); 6.5199 (1.16); 6.5077 (0.58); 6,4001 (1.15); 6,388 (2.43); 6.3758 (1.22); 6.268 (0.57); 6.256 (1.24); 6.2438 (0.64); 3,3392 (5.33); 3,3255 (5.78); 3.3214 (6.05); 3.3077 (5.49); 2.1185 (5.02); 2.048 (0.94); 2.0114 (0.44); 1.2786 (0.39); 1.2607 (0.77); 1.2534 (0.74); 1.2428 (0.38); 1,1001 (0.41); 1.0925 (0.57); 1.0804 (1.15); 1.0741 (0.98); 1.0703 (0.77); 1.0622 (1.92);
1 ,0544 (0,82); 1 ,0501 (1 ,06); 1 ,0424 (1 ,32); 1 ,0304 (0,7); 1 ,0243 (0,5); 0,593 (1 ,51 ); 0,581 (4,28); 0,5783 (4,96); 0,5735 (2,28); 0,5666 (2,12); 0,5611 (4,76); 0,5583 (4,22); 0,5467 (1,89); 0,2974 (1,72); 0,2858 (5,57); 0,2739 (4,43); 0,2712 (5,82); 0,2591 (1,38); 0,008 (0,54); -0,0002 (22,1); -0,0085 (0,78); Verbindung Nr.1924, Lösungsmittel: [CDCI3], 400 MHz 1, 0544 (0.82); 1, 0501 (1, 06); 1, 0424 (1, 32); 1, 0304 (0.7); 1, 0243 (0.5); 0.593 (1, 51); 0.581 (4.28); 0.5783 (4.96); 0.5735 (2.28); 0.5666 (2.12); 0.5611 (4.76); 0.5583 (4.22); 0.5467 (1.89); 0.2974 (1.72); 0.2858 (5.57); 0.2739 (4.43); 0.2712 (5.82); 0.2591 (1.38); 0.008 (0.54); -0.0002 (22.1); -0.0085 (0.78); Compound No.1924, solvent: [CDCl3], 400 MHz
8,8401 (0,86); 8,4303 (4,54); 7,3135 (0,42); 7,2633 (35,51); 6,5831 (0,62); 6,571 (1,25); 6,5588 (0,63); 6,4511 (1,27); 6,439 (2,58); 6,4268 (1,3); 6,3192 (0,64); 6,307 (1 ,31 ); 6,2948 (0,66); 3,5955 (3,08); 3,58 (6,11 ); 3,5635 (11 ,29); 3,5489 (14,61 );  8.8401 (0.86); 8,4303 (4,54); 7.3135 (0.42); 7.2633 (35.51); 6.5831 (0.62); 6.571 (1.25); 6.5588 (0.63); 6.4511 (1.27); 6,439 (2.58); 6,4268 (1.3); 6.3192 (0.64); 6,307 (1, 31); 6.2948 (0.66); 3.5955 (3.08); 3.58 (6.11); 3.5635 (11, 29); 3.5489 (14.61);
3,5341 (6,59); 3,4464 (0,65); 3,3958 (50); 3,348 (0,37); 1,9355 (1,68); 1,9205 (5,03); 1 ,905 (6,44); 1 ,8893 (4,77); 1 ,8742 (1 ,52); 0,0079 (0,72); 0,0008 (14,44); -0,0002 (18,78); -0,0072 (0,45); -0,0086 (0,5); 3.5341 (6.59); 3.4464 (0.65); 3,3958 (50); 3,348 (0.37); 1.9355 (1.68); 1.9205 (5.03); 1, 905 (6,44); 1, 8893 (4,77); 1, 8742 (1, 52); 0.0079 (0.72); 0.0008 (14.44); -0,0002 (18,78); -0.0072 (0.45); -0.0086 (0.5);
Verbindung Nr.2215, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2215, solvent: [CDCl3], 400 MHz
8,7826 (0,49); 8,2616 (2,5); 7,262 (50); 6,5476 (0,46); 6,5356 (0,92); 6,5235 (0,45); 6,4155 (0,92); 6,4036 (1 ,89); 6,3915 (0,95); 6,2835 (0,46); 6,2715 (0,97); 6,2595 (0,5); 3,5986 (2,3); 3,5831 (4,19); 3,5683 (8,85); 3,5536 (11,04); 3,5393 (5,06); 3,3984 (43,07); 3,3694 (0,31); 1,9357 (1,23); 1,9208 (3,42); 1,9044 (4,29); 1,8895 (3,35); 1,8747 (1,18); 0,0079 (0,84); -0,0002 (30,48); -0,0086 (0,86); Verbindung Nr.2220, Lösungsmittel: [CDCI3], 400 MHz  8.7826 (0.49); 8.2616 (2.5); 7,262 (50); 6.5476 (0.46); 6.5356 (0.92); 6.5235 (0.45); 6.4155 (0.92); 6,4036 (1, 89); 6.3915 (0.95); 6.2835 (0.46); 6.2715 (0.97); 6.2595 (0.5); 3.5986 (2.3); 3,5831 (4,19); 3,5683 (8,85); 3.5536 (11.04); 3,5393 (5.06); 3,3984 (43.07); 3.3694 (0.31); 1.9357 (1.23); 1.9208 (3.42); 1,9044 (4,29); 1.8895 (3.35); 1.8747 (1.18); 0.0079 (0.84); -0,0002 (30,48); -0.0086 (0.86); Compound No. 2220, solvent: [CDCl3], 400 MHz
0,1464 (0,7); 0,0697 (1,57); 0,0524 (0,42); 0,019 (0,42); 0,0174 (0,47); 0,0157 (0,52); 0,0149 (0,54); 0,0141 (0,57); 0,0133 (0,62); 0,0124 (0,68); 0,0116 (0,79); 0,0108 (1,03); 0,0083 (5,31); 0,0059 (2,36); 0,0051 (2,85); 0 (174,28); -0,005 (1,82); -0,0058 (1,31); -0,0083 (4,88); -0,0515 (0,43); -0,149 (0,66); Verbindung Nr.2219, Lösungsmittel: [CDCI3], 400 MHz 0.1464 (0.7); 0.0697 (1.57); 0.0524 (0.42); 0.019 (0.42); 0.0174 (0.47); 0.0157 (0.52); 0.0149 (0.54); 0.0141 (0.57); 0.0133 (0.62); 0.0124 (0.68); 0.0116 (0.79); 0.0108 (1.03); 0.0083 (5.31); 0.0059 (2.36); 0.0051 (2.85); 0 (174,28); -0.005 (1.82); -0.0058 (1.31); -0.0083 (4.88); -0.0515 (0.43); -0.149 (0.66); Compound No. 2219, solvent: [CDCl3], 400 MHz
0,1461 (0,39); 0,0539 (0,28); 0,0105 (0,44); 0,0081 (2,8); 0,0056 (1,13); 0,0022 (11,59); 0 (102,98); -0,0053 (2,22); -0,0061 (1,79); -0,0085 (3,22); -0,0094 (2,01); - 0,0119 (0,68); -0,0127 (0,55); -0,0135 (0,5); -0,0151 (0,42); -0,0159 (0,4); -0,0168 (0,36); -0,0184 (0,33); -0,0477 (0,39); -0,0526 (0,47); -0,1494 (0,4); 0.1461 (0.39); 0.0539 (0.28); 0.0105 (0.44); 0.0081 (2.8); 0.0056 (1.13); 0.0022 (11.59); 0 (102.98); -0.0053 (2.22); -0.0061 (1.79); -0.0085 (3.22); -0.0094 (2.01); - 0.0119 (0.68); -0.0127 (0.55); -0.0135 (0.5); -0.0151 (0.42); -0.0159 (0.4); -0.0168 (0.36); -0.0184 (0.33); -0.0477 (0.39); -0.0526 (0.47); -0.1494 (0.4);
Verbindung Nr.2096, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2096, solvent: [CDCl3], 400 MHz
12,3751 (0,33); 9,3183 (1,64); 8,6946 (11,42); 8,6919 (11,21); 7,2667 (0,37); 7,2659 (0,52); 7,2612 (50); 7,2575 (1 ,05); 7,2566 (0,76); 7,2558 (0,58); 7,2549 (0,46); 7,2541 (0,38); 7,2533 (0,31); 6,1695 (0,83); 6,1559 (2,78); 6,1423 (2,96); 6,1285 (1); 6,0627 (0,81); 6,0492 (2,76); 6,0355 (3,02); 6,0218 (1,05); 3,4904 (0,43); 3,4746 (2,02);  12.3751 (0.33); 9,3183 (1.64); 8, 6946 (11:42); 8, 6919 (11,21); 7.2667 (0.37); 7.2659 (0.52); 7,2612 (50); 7,2575 (1, 05); 7.2566 (0.76); 7.2558 (0.58); 7.2549 (0.46); 7.2541 (0.38); 7.2533 (0.31); 6.1695 (0.83); 6.1559 (2.78); 6,1423 (2,96); 6,1285 (1); 6.0627 (0.81); 6.0492 (2.76); 6.0355 (3.02); 6.0218 (1.05); 3.4904 (0.43); 3.4746 (2.02);
3,4665 (1,98); 3,4568 (4,35); 3,4526 (2,75); 3,4488 (4,08); 3,4426 (4,11); 3,4386 (2,82); 3,4348 (4,38); 3,4246 (2,08); 3,4171 (2,13); 3,401 (0,46); 1,6257 (1,57); 1,6078 (4,87); 1 ,6016 (1 ,79); 1 ,5896 (6,36); 1 ,5838 (3,29); 1 ,5706 (5,41 ); 1 ,5522 (2,38); 3.4665 (1.98); 3.4568 (4.35); 3.4526 (2.75); 3.4488 (4.08); 3,4426 (4,11); 3.4386 (2.82); 3.4348 (4.38); 3.4246 (2.08); 3.4171 (2.13); 3.401 (0.46); 1.6257 (1.57); 1.6078 (4.87); 1, 6016 (1, 79); 1, 5896 (6,36); 1, 5838 (3,29); 1, 5706 (5.41); 1, 5522 (2.38);
1 ,4549 (1 ,29); 1 ,4364 (3,95); 1 ,4227 (2,22); 1 ,4174 (5,42); 1 ,4043 (2,32); 1 ,3982 (5,55); 1,3861 (1,02); 1,3802 (3,48); 1,3621 (1,09); 0,9653 (15,68); 0,947 (32,38); 0,9286 (13,57); 0,0078 (0,71); -0,0002 (28,52); -0,0057 (0,52); -0,0065 (0,44); -0,0083 (0,95); -0,0089 (0,93); 1, 4549 (1, 29); 1, 4364 (3.95); 1, 4227 (2.22); 1, 4174 (5.42); 1, 4043 (2.32); 1, 3982 (5,55); 1.3861 (1.02); 1.3802 (3.48); 1.3621 (1.09); 0.9653 (15.68); 0.947 (32.38); 0.9286 (13.57); 0.0078 (0.71); -0.0002 (28.52); -0.0057 (0.52); -0.0065 (0.44); -0.0083 (0.95); -0.0089 (0.93);
Verbindung Nr.2126, Lösungsmittel: [DMSO], 400 MHz Compound No. 2126, solvent: [DMSO], 400 MHz
8,4268 (1,22); 6,63 (0,3); 6,5251 (0,31); 3,3633 (0,42); 3,3171 (18,18); 3,1688 (0,37); 2,55 (0,46); 2,5456 (0,58); 2,5411 (0,42); 2,5237 (0,66); 2,519 (0,86); 2,5103 (15,4); 2,5057 (35,25); 2,5011 (50); 2,4964 (35,48); 2,4918 (16,07); 2,4624 (0,49); 2,458 (0,45); 1,4655(0,36); 1,4435(0,32); 1,3112(0,31); 1,2972(0,35); 1,2767(0,49); 1,145 (2,45); 1,1286 (2,41); 0,8863 (5,06); 0,8698 (5,14); -0,0002 (4,67);  8,4268 (1.22); 6.63 (0.3); 6.5251 (0.31); 3.3633 (0.42); 3,3171 (18,18); 3.1688 (0.37); 2.55 (0.46); 2.5456 (0.58); 2.5411 (0.42); 2.5237 (0.66); 2,519 (0.86); 2,5103 (15.4); 2,5057 (35,25); 2,5011 (50); 2.4964 (35.48); 2,4918 (16.07); 2.4624 (0.49); 2.458 (0.45); 1.4655 (0.36); 1.4435 (0.32); 1.3112 (0.31); 1.2972 (0.35); 1.2767 (0.49); 1,145 (2.45); 1.1286 (2.41); 0.8863 (5.06); 0.8698 (5.14); -0,0002 (4,67);
Verbindung Nr.2230, Lösungsmittel: [DMSO], 400 MHz Compound No. 2230, solvent: [DMSO], 400 MHz
8,5233 (0,92); 3,3137 (35,51); 3,1685 (0,41); 2,8574 (0,36); 2,8471 (0,37); 2,5234 (0,65); 2,5187 (0,85); 2,51 (15,41); 2,5054 (35,21); 2,5008 (50); 2,4961 (35,18); 2,4915 (15,65); 2,0721 (0,63); 0,7534 (0,63); 0,7479 (0,88); 0,7355 (0,88); 0,7298 (0,66); 0,7178 (0,3); 0,5698 (0,69); 0,5632 (0,65); 0,5588 (0,6); 0,5535 (0,6); -0,0002 (4,73) Verbindung Nr.2231, Lösungsmittel: [DMSO], 400 MHz 8.5233 (0.92); 3,3137 (35.51); 3.1685 (0.41); 2.8574 (0.36); 2.8471 (0.37); 2.5234 (0.65); 2.5187 (0.85); 2.51 (15.41); 2,5054 (35,21); 2,5008 (50); 2,4961 (35,18); 2,4915 (15,65); 2.0721 (0.63); 0.7534 (0.63); 0.7479 (0.88); 0.7355 (0.88); 0.7298 (0.66); 0.7178 (0.3); 0.5698 (0.69); 0.5632 (0.65); 0.5588 (0.6); 0.5535 (0.6); -0,0002 (4.73) Compound No. 2231, solvent: [DMSO], 400 MHz
8,5564 (1,06); 6,5033 (0,33); 6,488 (0,34); 6,3985 (0,32); 6,3833 (0,36); 5,7526 (1,26); 3,9721 (0,34); 3,317 (16,71); 3,1691 (0,46); 2,5239 (0,55); 2,5193 (0,74); 2,5106 (15,16); 2,506 (34,94); 2,5013 (50); 2,4967 (35,25); 2,4921 (15,87); 2,4531 (0,32); 1,4701 (0,5); 1,4516(0,31); 1,2783(1,05); 1,2707(1,18); 1,2614 (1,68); 1,2347 (0,51); 1,146 (2,68); 1,1303 (2,7); 0,8682 (0,83); 0,8517 (3,11); 0,8345 (1,03); -0,0002 (10,3); -0,0085 (0,32); Verbindung Nr.2232, Lösungsmittel: [DMSO], 400 MHz  8.5564 (1.06); 6.5033 (0.33); 6,488 (0.34); 6,3985 (0.32); 6.3833 (0.36); 5.7526 (1.26); 3.9721 (0.34); 3,317 (16.71); 3.1691 (0.46); 2.5239 (0.55); 2.5193 (0.74); 2,5106 (15,16); 2,506 (34.94); 2,5013 (50); 2,4967 (35,25); 2,4921 (15,87); 2.4531 (0.32); 1.4701 (0.5); 1.4516 (0.31); 1.2783 (1.05); 1.2707 (1.18); 1.2614 (1.68); 1.2347 (0.51); 1.146 (2.68); 1.1303 (2.7); 0.8682 (0.83); 0.8517 (3.11); 0.8345 (1.03); -0,0002 (10,3); -0.0085 (0.32); Compound No. 2232, solvent: [DMSO], 400 MHz
8,5637 (0,77); 6,3904 (0,31); 3,4784 (0,46); 3,4674 (0,82); 3,4575 (2,17); 3,4509 (1,13); 3,3143 (20,1); 3,2703 (10,86); 3,1685 (0,38); 2,5234 (0,58); 2,5187 (0,77); 2,51 (15,25); 2,5054 (34,86); 2,5007 (50); 2,4961 (35,24); 2,4915 (15,71); -0,0002 (1,61); Verbindung Nr.2233, Lösungsmittel: [DMSO], 400 MHz  8.5637 (0.77); 6.3904 (0.31); 3.4784 (0.46); 3.4674 (0.82); 3.4575 (2.17); 3.4509 (1.13); 3,3143 (20,1); 3,2703 (10,86); 3.165 (0.38); 2.5234 (0.58); 2.5187 (0.77); 2,51 (15,25); 2,5054 (34,86); 2,5007 (50); 2,4961 (35,24); 2,4915 (15,71); -0,0002 (1.61); Compound No. 2233, solvent: [DMSO], 400 MHz
8,5551 (1,32); 6,5024 (0,47); 6,4872 (0,52); 6,3976 (0,46); 6,3823 (0,52); 3,3998 (0,79); 3,3951 (1,79); 3,3848 (1,53); 3,3796 (4,04); 3,3735 (0,89); 3,3698 (1,11);  8.5551 (1.32); 6.5024 (0.47); 6.4872 (0.52); 6.3976 (0.46); 6.3823 (0.52); 3.3998 (0.79); 3,3951 (1.79); 3.3848 (1.53); 3,3796 (4.04); 3.3735 (0.89); 3.3698 (1.11);
3,3641 (2,08); 3,3567 (1,71); 3,3417 (1,94); 3,3166 (17,14); 3,2834 (0,34); 3,2381 (21,77); 3,1687 (0,42); 2,5239 (0,7); 2,5192 (0,92); 2,5105 (15,37); 2,5059 (35,13); 2,5013 (50); 2,4966 (35,35); 2,492 (15,92); 1 ,7895 (0,33); 1 ,7727 (0,62); 1 ,7563 (1 ,36); 1,7403 (1,92); 1,7242 (1,15); 1,7078 (0,33); -0,0002 (2,14); 3.3641 (2.08); 3.3567 (1.71); 3.3417 (1.94); 3,3166 (17,14); 3.2834 (0.34); 3,2381 (21.77); 3.1687 (0.42); 2.5239 (0.7); 2,5192 (0.92); 2,5105 (15.37); 2,5059 (35,13); 2,5013 (50); 2.4966 (35.35); 2,492 (15.92); 1, 7895 (0.33); 1, 7727 (0.62); 1, 7563 (1, 36); 1.7403 (1.92); 1.7242 (1.15); 1.7078 (0.33); -0,0002 (2,14);
Verbindung Nr.2128, Lösungsmittel: [DMSO], 400 MHz Compound No. 2128, solvent: [DMSO], 400 MHz
8,412 (1,92); 8,4095 (1,93); 6,6529 (0,36); 6,6374 (0,38); 6,548 (0,35); 6,5328 (0,37); 5,7527 (2,06); 3,8704 (0,42); 3,8494 (0,42); 3,8341 (0,33); 3,3306 (5,07); 3,1691 (0,57); 2,5239 (0,58); 2,5192 (0,77); 2,5105 (15,19); 2,5059 (35,08); 2,5013 (50);  8.412 (1.92); 8.4095 (1.93); 6.6529 (0.36); 6,6374 (0.38); 6.548 (0.35); 6.5328 (0.37); 5,7527 (2,06); 3.8704 (0.42); 3.8494 (0.42); 3.8341 (0.33); 3,3306 (5,07); 3.1691 (0.57); 2.5239 (0.58); 2.5192 (0.77); 2,5105 (15,19); 2,5059 (35.08); 2,5013 (50);
2,4966 (35,41); 2,492 (15,88); 1,7788 (0,35); 1,762 (0,55); 1,7465 (0,56); 1,7297 (0,39); 1,1076 (3,08); 1,1052 (3,24); 1,0907 (3,1); 1,0883 (3,21); 0,9007 (4,65); 0,8948 (4,35); 0,8837 (4,62); 0,8779 (4,18); -0,0002 (12,11); -0,0085 (0,35); 2.4966 (35.41); 2,492 (15,88); 1.7788 (0.35); 1,762 (0.55); 1.7465 (0.56); 1.7297 (0.39); 1,1076 (3,08); 1,1052 (3,24); 1.0907 (3.1); 1.0883 (3.21); 0.9007 (4.65); 0.8948 (4.35); 0.8837 (4.62); 0.8779 (4.18); -0,0002 (12.11); -0.0085 (0.35);
Verbindung Nr.2234, Lösungsmittel: [DMSO], 400 MHz Compound No. 2234, solvent: [DMSO], 400 MHz
3,3126 (40,61); 2,5233 (0,63); 2,5187 (0,86); 2,51 (15,25); 2,5054 (35,14); 2,5007 (50); 2,4961 (35,27); 2,4915 (15,71); 2,0721 (0,35); 1,5188 (0,46); 1,5005 (0,65); 1,483 (0,45); 1,154 (0,37); 1,1421 (1,44); 1,1401 (1,53); 1,1256 (1,42); 1,1236 (1,45); 0,8941 (0,47); 0,8894 (0,91); 0,8707 (1,8); 0,8524 (0,77); -0,0002 (4,93); 3,3126 (40,61); 2.5233 (0.63); 2.5187 (0.86); 2,51 (15,25); 2,5054 (35,14); 2,5007 (50); 2,4961 (35,27); 2,4915 (15,71); 2.0721 (0.35); 1.5188 (0.46); 1.5005 (0.65); 1,483 (0.45); 1.154 (0.37); 1.1421 (1.44); 1,1401 (1.53); 1.1256 (1.42); 1.1236 (1.45); 0.8941 (0.47); 0.8894 (0.91); 0.8707 (1.8); 0.8524 (0.77); -0.0002 (4.93);
Verbindung Nr.2235, Lösungsmittel: [DMSO], 400 MHz Compound No. 2235, solvent: [DMSO], 400 MHz
8,5434 (1 ,4); 6,5103 (0,31 ); 6,495 (0,33); 6,4057 (0,31 ); 6,3906 (0,31 ); 3,8671 (0,37); 3,846 (0,35); 3,3268 (3,6); 2,524 (0,57); 2,5194 (0,74); 2,5107 (15,16); 2,5061 (34,98); 2,5014 (50); 2,4968 (35,24); 2,4921 (15,63); 1,7731 (0,32); 1,7562 (0,47); 1,7411 (0,5); 1,7241 (0,34); 1,1017 (2,59); 1,0992 (2,9); 1,0848 (2,62); 1,0823 (2,85); 0,8973 (3,95); 0,8903 (3,5); 0,8803 (3,94); 0,8733 (3,32); -0,0002 (3,98); 8,5434 (1, 4); 6.5103 (0.31); 6,495 (0.33); 6,4057 (0.31); 6.3906 (0.31); 3.8671 (0.37); 3,846 (0.35); 3.3268 (3.6); 2,524 (0.57); 2.5194 (0.74); 2,5107 (15,16); 2.5061 (34.98); 2.504 (50); 2,4968 (35,24); 2.4921 (15.63); 1.7731 (0.32); 1.7562 (0.47); 1.7411 (0.5); 1.7241 (0.34); 1,1017 (2.59); 1.0992 (2.9); 1.0848 (2.62); 1.0823 (2.85); 0.8973 (3.95); 0.8903 (3.5); 0.8803 (3.94); 0.8733 (3.32); -0,0002 (3,98);
Verbindung Nr.2127, Lösungsmittel: [DMSO], 400 MHz Compound No. 2127, solvent: [DMSO], 400 MHz
8,3884 (3,9); 6,6602 (0,61); 6,6476 (0,62); 6,6448 (0,63); 6,5587 (0,62); 6,5559 (0,63); 8,3884 (3,9); 6.6602 (0.61); 6,6476 (0.62); 6.6448 (0.63); 6.5587 (0.62); 6.5559 (0.63);
6,5434 (0,69); 6,5404 (0,66); 5,7528 (0,86); 3,9199 (0,3); 3,9028 (1,07); 3,897 (0,39);6.5434 (0.69); 6.5404 (0.66); 5.7528 (0.86); 3.9199 (0.3); 3.9028 (1.07); 3.897 (0.39);
3,8857 (1,14); 3,8797 (1,12); 3,8687 (0,44); 3,8626 (1,09); 3,8455 (0,33); 3,8353 (0,33); 3,3824 (3,34); 3,256 (0,54); 3,24 (0,46); 3,1705 (0,84); 2,5252 (0,33); 2,52053.8857 (1.14); 3.8797 (1.12); 3.8687 (0.44); 3.8626 (1.09); 3.8455 (0.33); 3.8353 (0.33); 3,3824 (3,34); 3.256 (0.54); 3.24 (0.46); 3.170 (0.84); 2.5252 (0.33); 2.5205
(0,45); 2,5119 (13,2); 2,5073 (30,48); 2,5026 (43,96); 2,498 (31,34); 2,4934 (14,21);(0.45); 2,5119 (13.2); 2,5073 (30,48); 2.506 (43.96); 2,498 (31.34); 2,4934 (14,21);
2,0983 (0,47); 2,0733 (0,39); 1,7122 (0,42); 1,083 (5,45); 1,0794 (5,88); 1,0693 (2,41);2.0983 (0.47); 2.0733 (0.39); 1.7122 (0.42); 1,083 (5.45); 1.0794 (5.88); 1.0693 (2.41);
1,066 (5,6); 1,0624 (5,88); 1,0567 (1,78); 1,0092 (0,34); 0,9752 (0,82); 0,9711 (0,41);1.066 (5.6); 1.0624 (5.88); 1.0567 (1.78); 1,0092 (0.34); 0.9752 (0.82); 0.9711 (0.41);
0,9593 (0,83); 0,954 (0,61); 0,9512 (0,48); 0,9188 (1,34); 0,9031 (50); 0,8697 (0,51); 0,865 (0,51 ); 0,8532 (0,63); 0,8432 (0,51 ); 0,8374 (2,08); 0,824 (0,61 ); 0,8177 (0,61 );0.9593 (0.83); 0.954 (0.61); 0.9512 (0.48); 0.9188 (1.34); 0.9031 (50); 0.8697 (0.51); 0.865 (0.51); 0.8532 (0.63); 0.8432 (0.51); 0.8374 (2.08); 0.824 (0.61); 0.8177 (0.61);
0,8033 (4,27); -0,0002 (8,79); 0.8033 (4.27); -0,0002 (8,79);
Verbindung Nr.1445, Lösungsmittel: [CDCI3], 400 MHz Compound No. 1445, solvent: [CDCl3], 400 MHz
9,3978 (0,45); 8,6158 (3,29); 8,613 (3,22); 7,2609 (21,23); 6,1627 (0,82); 6,1491 (0,87); 6,0558 (0,82); 6,0421 (0,89); 6,0284 (0,31 ); 3,339 (0,77); 3,3228 (0,79); 3,3059 (1,73); 3,2897 (1,69); 3,2568 (1,67); 3,2415 (1,74); 3,2237 (0,79); 3,2084 (0,76);  9.3978 (0.45); 8,6158 (3,29); 8,613 (3,22); 7.2609 (21.23); 6.1627 (0.82); 6.1491 (0.87); 6.0558 (0.82); 6.0421 (0.89); 6.0284 (0.31); 3,339 (0.77); 3,3228 (0.79); 3.3059 (1.73); 3,2897 (1.69); 3.2568 (1.67); 3.2415 (1.74); 3.2237 (0.79); 3,2084 (0.76);
1,0976 (0,52); 0,9727 (50); -0,0002 (10,36); -0,0082 (0,33); 1.0976 (0.52); 0.9727 (50); -0.0002 (10.36); -0.0082 (0.33);
Verbindung Nr.1489, Lösungsmittel: [CDCI3], 400 MHz Compound No. 1489, solvent: [CDCl3], 400 MHz
9,7362 (0,94); 8,5617 (4,87); 8,5592 (4,88); 7,2621 (50); 6,1699 (0,38); 6,1564 (1,3); 6,1428 (1,38); 6,1293 (0,47); 6,0628 (0,39); 6,0494 (1,3); 6,0358 (1,4); 6,0221 (0,48); 4,2457 (4,03); 4,2418 (4,02); 4,2317 (4,14); 4,2278 (4,13); 4,0384 (0,66); 4,0261 (1,1); 3,7822 (28,47); 3,7554 (2,68); 3,7504 (0,73); 3,7356 (0,47); 3,7182 (0,96); 1,8554 (0,75); 1,8467 (0,31); 1,5889 (0,48); 1,4322 (2,32); 1,2539 (0,63); 0,008 (0,74); - 0,0002 (27,06); -0,0085 (0,99); 9.7362 (0.94); 8,5617 (4,87); 8,5592 (4,88); 7,2621 (50); 6.1699 (0.38); 6.1564 (1.3); 6,1428 (1,38); 6.1293 (0.47); 6.0628 (0.39); 6.0494 (1.3); 6.0358 (1.4); 6.0221 (0.48); 4.2457 (4.03); 4.2418 (4.02); 4,2317 (4,14); 4,2278 (4,13); 4.0384 (0.66); 4.0261 (1.1); 3,7822 (28,47); 3,7554 (2.68); 3.7504 (0.73); 3.7356 (0.47); 3.7182 (0.96); 1.8554 (0.75); 1.8467 (0.31); 1.5889 (0.48); 1.4322 (2.32); 1.2539 (0.63); 0.008 (0.74); - 0.0002 (27.06); -0.0085 (0.99);
Verbindung Nr.1462, Lösungsmittel: [CDCI3], 400 MHz Compound No. 1462, solvent: [CDCl3], 400 MHz
9,2378 (1,17); 9,2175 (1 ,2); 8,5984 (7,02); 8,5962 (7,34); 7,3115 (0,33); 7,261 (50); 6,1988 (0,56); 6,185 (1,83); 6,1713 (1 ,92); 6,1576 (0,66); 6,0917 (0,55); 6,0782 (1,81); 6,0645 (1,97); 6,0508 (0,7); 5,2986 (2,24); 4,2107 (0,67); 4,194 (1,33); 4,1737 (1,59); 4,1568 (1,4); 4,14 (0,72); 4,0216 (0,94); 1,5612 (1,02); 1,5502 (1,35); 1,5452 (1,37); 1,5309 (2,46); 1,5109 (3,93); 1,4939 (3,95); 1,478 (2,27); 1,4603 (0,92); 1,4456 (0,78); 1 ,4306 (0,83); 1 ,4082 (1 ,8); 1 ,3917 (2,69); 1 ,384 (2,1 ); 1 ,3764 (2,3); 1 ,3669 (1 ,95); 1,3582 (1,38); 1,3498 (1,23); 1,2559 (0,5); 1,222 (10,2); 1,2179 (10,37); 1,2056 (10,37); 1,2015 (10,26); 0,941 (10,07); 0,9228 (19,94); 0,9049 (8,24); 0,008 (0,57); - 0,0002 (22,8); -0,0084 (0,88); Verbindung Nr.1975, Lösungsmittel: [CDCI3], 400 MHz 9.2378 (1.17); 9,2175 (1, 2); 8,5984 (7.02); 8,5962 (7,34); 7.3115 (0.33); 7,261 (50); 6.1988 (0.56); 6.185 (1.83); 6,1713 (1, 92); 6.1576 (0.66); 6.0917 (0.55); 6.0782 (1.81); 6.0645 (1.97); 6.0508 (0.7); 5,2986 (2.24); 4,2107 (0.67); 4.194 (1.33); 4.1737 (1.59); 4.1568 (1.4); 4.14 (0.72); 4.0216 (0.94); 1.5612 (1.02); 1.5502 (1.35); 1.5452 (1.37); 1.5309 (2.46); 1.5109 (3.93); 1.4939 (3.95); 1.478 (2.27); 1.4603 (0.92); 1.4456 (0.78); 1, 4306 (0.83); 1, 4082 (1, 8); 1, 3917 (2.69); 1, 384 (2,1); 1, 3764 (2, 3); 1, 3669 (1, 95); 1.3582 (1.38); 1.3498 (1.23); 1.2559 (0.5); 1,222 (10,2); 1.2179 (10.37); 1,2056 (10,37); 1,2015 (10,26); 0.941 (10.07); 0.9228 (19.94); 0.9049 (8.24); 0.008 (0.57); - 0.0002 (22.8); -0.0084 (0.88); Compound No. 1975, solvent: [CDCl3], 400 MHz
7,9409 (2,4); 7,2595 (50); 6,6218 (0,35); 6,5029 (0,35); 6,4897 (0,73); 6,4765 (0,37); 6,3576 (0,34); 3,1367 (21,54); 1,5504 (2,88); 0,008 (0,73); -0,0002 (24,64); -0,0086 (1,05); Verbindung Nr.2239, Solvent: [DMSO], 400 MHz  7.9409 (2.4); 7,2595 (50); 6.6218 (0.35); 6,5029 (0.35); 6,4897 (0.73); 6,4765 (0.37); 6.3576 (0.34); 3,1367 (21.54); 1.5504 (2.88); 0.008 (0.73); -0.0002 (24.64); -0.0086 (1.05); Compound No. 2239, solvent: [DMSO], 400 MHz
8,7524 (6,37); 8,6706 (0,95); 8,649 (0,95); 7,0736 (0,53); 6,9576 (0,55); 6,944 (1,12); 6,9302 (0,55); 6,8143 (0,58); 6,8011 (0,31); 4,0309 (0,35); 4,0125 (0,76); 3,9956 (1,01); 3,9784 (0,75); 3,9606 (0,36); 3,343 (50); 3,1721 (0,4); 2,5132 (15,5); 2,5089 (34,58); 2,5044 (49,22); 2,4999 (35,88); 2,4955 (16,96); 1,5072 (0,89); 1,4912 (1,4); 1,4733 (1,22); 1,4567 (0,63); 1,2811 (3,22); 1,2656 (4,78); 1,16 (8,54); 1,1435 (8,48); 0,8706 (2,29); 0,8544 (6,77); 0,8372 (2,51); -0,0002 (8,13);  8,7524 (6,37); 8,6706 (0.95); 8,649 (0.95); 7.0736 (0.53); 6.9576 (0.55); 6,944 (1.12); 6.9302 (0.55); 6.8143 (0.58); 6.8011 (0.31); 4.0309 (0.35); 4.0125 (0.76); 3.9956 (1.01); 3.9784 (0.75); 3.9606 (0.36); 3,343 (50); 3.1721 (0.4); 2,5132 (15.5); 2.5089 (34.58); 2,5044 (49,22); 2.4999 (35.88); 2.4955 (16.96); 1.5072 (0.89); 1.4912 (1.4); 1.4733 (1.22); 1.4567 (0.63); 1.2811 (3.22); 1.2656 (4.78); 1.16 (8.54); 1.1435 (8.48); 0.8706 (2.29); 0.8544 (6.77); 0.8372 (2.51); -0,0002 (8,13);
Verbindung Nr.1790, Lösungsmittel: [CDCI3], 400 MHz Compound No. 1790, solvent: [CDCl3], 400 MHz
8,8072 (0,88); 8,6436 (7,69); 7,5188 (0,46); 7,26 (82,13); 6,996 (0,46); 3,6152 (1,05); 3,5957 (2,03); 3,5786 (2,06); 3,5588 (1 ,16); 1 ,659 (0,35); 1 ,6518 (0,35); 1 ,644 (0,36); 1,6379 (0,37); 1,6241 (0,38); 1,6126 (0,4); 1,587 (0,39); 1,5785 (0,4); 1,5442 (0,38); 1 ,5373 (0,36); 1 ,5244 (0,35); 1 ,4783 (0,39); 1 ,4618 (0,34); 1 ,3222 (16); 1 ,3057 (16); 0,9802 (0,33); 0,9674 (0,65); 0,9591 (1); 0,9469 (1,94); 0,9352 (1,36); 0,9264 (2,08); 0,9141 (1,19); 0,906 (0,85); 0,8938 (0,46); 0,6013 (0,49); 0,588 (0,78); 0,5782 (1,44); 0,566 (1,92); 0,5551 (1,82); 0,5446 (1,28); 0,5337 (1,07); 0,5267 (1,02); 0,5138 (1,57); 0,5021 (1,43); 0,4937 (2,06); 0,4806 (1,42); 0,4714 (0,83); 0,4595 (0,68); 0,4208 (0,73); 0,408 (1,51); 0,397 (1,98); 0,3848 (2,59); 0,3723 (2,05); 0,36 (0,78); 0,3083 (0,92); 0,296 (2,09); 0,2843 (2,49); 0,2723 (2,16); 0,2607 (1,33); 0,2491 (0,53); 0,0076 (0,86); 0 (33,52); 8.8072 (0.88); 8.6436 (7.69); 7.5188 (0.46); 7:26 (82:13); 6.996 (0.46); 3.6152 (1.05); 3.5957 (2.03); 3.5786 (2.06); 3,5588 (1, 16); 1, 659 (0.35); 1, 6518 (0.35); 1, 644 (0.36); 1.6379 (0.37); 1.6241 (0.38); 1.6126 (0.4); 1,587 (0.39); 1.5785 (0.4); 1.5442 (0.38); 1, 5373 (0.36); 1, 5244 (0.35); 1, 4783 (0.39); 1, 4618 (0.34); 1, 3222 (16); 1, 3057 (16); 0.9802 (0.33); 0.9674 (0.65); 0.9591 (1); 0.9469 (1.94); 0.9352 (1.36); 0.9264 (2.08); 0.9141 (1.19); 0.906 (0.85); 0.8938 (0.46); 0.6013 (0.49); 0.588 (0.78); 0.5782 (1.44); 0.566 (1.92); 0.5551 (1.82); 0.5446 (1.28); 0.5337 (1.07); 0.5267 (1.02); 0.5138 (1.57); 0.5021 (1.43); 0.4937 (2.06); 0.4806 (1.42); 0.4714 (0.83); 0.4595 (0.68); 0.4208 (0.73); 0.408 (1.51); 0.397 (1.98); 0.3848 (2.59); 0.3723 (2.05); 0.36 (0.78); 0.3083 (0.92); 0.296 (2.09); 0.2843 (2.49); 0.2723 (2.16); 0.2607 (1.33); 0.2491 (0.53); 0.0076 (0.86); 0 (33.52);
Verbindung Nr.1460, Lösungsmittel: [DMSO], 400 MHz Compound No. 1460, solvent: [DMSO], 400 MHz
8,0921 (1,4); 8,0899 (1,43); 6,4804 (0,37); 6,4649 (0,39); 6,3757 (0,39); 6,3601 (0,39); 3,2543 (0,36); 3,2354 (0,37); 3,0772 (1,58); 2,2679 (4,99); 2,2634 (11,3); 2,2588 (16); 2,2541 (11 ,79); 2,2496 (5,7); 1 ,1134 (1 ,46); 0,9853 (2,3); 0,9834 (2,42); 0,9687 (2,31 ); 0,9667 (2,37); 0,7505 (0,43); 0,7302 (0,46); 0,2359 (0,34); 0,2267 (0,34); 0,2227 (0,35); 0,2147 (0,49); 0,169 (0,39); 0,1586 (0,39); 0,1477 (0,39); 0,039 (0,47); 0,0272 (0,44); 0,0229 (0,35); 0,0142 (0,36); 0,0094 (0,48); 0 (0,44); Verbindung Nr.1901, Lösungsmittel: [DMSO], 400 MHz  8.0921 (1.4); 8.0899 (1.43); 6.4804 (0.37); 6,4649 (0.39); 6.3757 (0.39); 6.3601 (0.39); 3.2543 (0.36); 3.2354 (0.37); 3.0772 (1.58); 2.2679 (4.99); 2.2634 (11.3); 2,2588 (16); 2,2541 (11, 79); 2.2496 (5.7); 1, 1134 (1, 46); 0.9853 (2.3); 0.9834 (2.42); 0.9687 (2.31); 0.9667 (2.37); 0.7505 (0.43); 0.7302 (0.46); 0.2359 (0.34); 0.2267 (0.34); 0.2227 (0.35); 0.2147 (0.49); 0.169 (0.39); 0.1586 (0.39); 0.1477 (0.39); 0.039 (0.47); 0.0272 (0.44); 0.0229 (0.35); 0.0142 (0.36); 0.0094 (0.48); 0 (0.44); Compound No. 1901, solvent: [DMSO], 400 MHz
9,0841 (0,79); 8,3959 (10,95); 7,7958 (0,34); 7,0784 (0,61); 7,065 (1,23); 7,0514 (0,64); 6,9488 (1,25); 6,9355 (2,6); 6,9219 (1,28); 6,8194 (0,62); 6,806 (1,33); 6,7925 (0,66); 4,8724 (0,35); 4,855 (0,93); 4,836 (1,52); 4,8162 (1,46); 4,8041 (0,79); 4,7963 (0,94); 4,7846 (0,32); 4,7775 (0,37); 3,3496 (5,6); 3,1652 (1,17); 2,6756 (1,57); 2,6711 (2,19); 2,6667 (1 ,5); 2,5497 (0,53); 2,5451 (1 ,33); 2,5411 (1 ,72); 2,5246 (6,07); 2,5199 (8,36); 2,511 (124,4); 2,5066 (268,94); 2,5021 (367,92); 2,4975 (261,2); 2,4931 (120,09); 2,3334 (1,58); 2,3289 (2,12); 2,3244 (1,48); 2,0587 (1,92); 1,3517 (16);  9.0841 (0.79); 8,3959 (10,95); 7.7958 (0.34); 7.0784 (0.61); 7.065 (1.23); 7.0514 (0.64); 6.9488 (1.25); 6.9355 (2.6); 6,9219 (1,28); 6.8194 (0.62); 6.806 (1.33); 6.7925 (0.66); 4.8724 (0.35); 4,855 (0.93); 4,836 (1.52); 4.8162 (1.46); 4,8041 (0.79); 4.7963 (0.94); 4.7846 (0.32); 4.7775 (0.37); 3.3496 (5.6); 3,1652 (1.17); 2.6756 (1.57); 2.6711 (2.19); 2.6667 (1, 5); 2.5497 (0.53); 2.5451 (1, 33); 2.5411 (1, 72); 2.5246 (6.07); 2,5199 (8,36); 2,511 (124.4); 2.5066 (268.94); 2.5021 (367.92); 2.4975 (261.2); 2.4931 (120.09); 2.3334 (1.58); 2,3289 (2,12); 2.3244 (1.48); 2.0587 (1.92); 1.3517 (16);
1,3342 (15,89); 0,1462 (0,61); 0,0481 (0,4); 0,0082 (4,28); Verbindung Nr.1828, Lösungsmittel: [CDCI3], 400 MHz 1.3342 (15.89); 0.1462 (0.61); 0.0481 (0.4); 0.0082 (4.28); Compound No. 1828, solvent: [CDCl3], 400 MHz
8,9958 (1,96); 8,978 (1,98); 8,6874 (16); 8,6861 (15,52); 7,5199 (1,05); 7,3106 (1,28); 8.9958 (1.96); 8,978 (1.98); 8, 6874 (16); 8,6861 (15,52); 7.5199 (1.05); 7.3106 (1.28);
7,3079 (0,43); 7,3072 (0,37); 7,281 (0,33); 7,2802 (0,39); 7,2794 (0,41); 7,2786 (0,42);7.3079 (0.43); 7.3072 (0.37); 7.281 (0.33); 7.2802 (0.39); 7.2794 (0.41); 7.2786 (0.42);
7,2778 (0,49); 7,2769 (0,55); 7,2761 (0,58); 7,2753 (0,64); 7,2745 (0,7); 7,2737 (0,76);7.2778 (0.49); 7.2769 (0.55); 7.2761 (0.58); 7.2753 (0.64); 7.2745 (0.7); 7.2737 (0.76);
7,2729 (0,86); 7,272 (0,94); 7,2712 (1,07); 7,2704 (1,23); 7,2696 (1,49); 7,2687 (1,82); 7,2679 (2,33); 7,2671 (2,94); 7,2662 (3,74); 7,2654 (5,06); 7,2611 (192,25); 7,25477.2729 (0.86); 7,272 (0.94); 7.2712 (1.07); 7.2704 (1.23); 7.2696 (1.49); 7.2687 (1.82); 7.2679 (2.33); 7.2671 (2.94); 7.2662 (3.74); 7.2654 (5.06); 7.2611 (192.25); 7.2547
(3,81); 7,2538 (3,23); 7,253 (2,83); 7,2522 (2,43); 7,2514 (2,11); 7,2505 (1,87); 7,2497(3.81); 7.2538 (3.23); 7.253 (2.83); 7.2522 (2.43); 7.2514 (2.11); 7.2505 (1.87); 7.2497
(1,63); 7,2489 (1,46); 7,2481 (1,34); 7,2473 (1,19); 7,2464 (1,08); 7,2456 (0,98); (1.63); 7.2489 (1.46); 7.2481 (1.34); 7.2473 (1.19); 7.2464 (1.08); 7.2456 (0.98);
7,2448 (0,9); 7,244 (0,85); 7,2432 (0,8); 7,2424 (0,74); 7,2415 (0,69); 7,2407 (0,66); 7.2448 (0.9); 7.244 (0.85); 7.2432 (0.8); 7.2424 (0.74); 7.2415 (0.69); 7.2407 (0.66);
7,2399 (0,64); 7,2391 (0,6); 7,2383 (0,57); 7,2375 (0,53); 7,2367 (0,45); 7,2359 (0,42); 7,235 (0,4); 7,2342 (0,37); 7,2334 (0,36); 6,9972 (1,04); 3,4954 (0,62); 3,3334 (2,82); 3,3134 (7,05); 3,2924 (7,11); 3,2724 (2,95); 2,0065 (4,84); 1,0509 (1,6); 1,0382 (3,54); 1,0308 (5); 1,0258 (2,89); 1,0181 (9,87); 1,0108 (6,1); 1,0056 (6,36); 0,998 (10,45); 0,991 (2,94); 0,9855 (6); 0,978 (4,34); 0,9654 (2,19); 0,6018 (2,95); 0,5931 (3,92); 0,5896 (4,37); 0,5806 (10,36); 0,5718 (7,82); 0,5688 (7,26); 0,5673 (7,47); 0,5595 (8,59); 0,5575 (7,86); 0,5514 (5); 0,5467 (5,83); 0,5368 (5,23); 0,4868 (3,8); 0,476 (6,02); 0,473 (5,9); 0,4666 (4,43); 0,4622 (7,93); 0,4557 (7,7); 0,4528 (7,61); 0,4508 (5,62); 0,4416 (11,14); 0,4383 (6,12); 0,4349 (4,86); 0,4304 (4,6); 0,4246 (6,85); 0,421 (6,58); 0,415 (8,63); 0,4109 (4,81); 0,4022 (13,33); 0,3918 (11,99); 0,3891 (8,96); 0,3849 (8,61); 0,3792 (7,43); 0,376 (8,08); 0,3721 (11,26); 0,3629 (10,11); 0,3588 (5,94); 0,3498 (7,54); 0,3403 (4,09); 0,327 (2,11); 0,0495 (0,38); 0,0082 (1,65); 0 (60,44); 7.2399 (0.64); 7.2391 (0.6); 7.2383 (0.57); 7.2375 (0.53); 7.2367 (0.45); 7.2359 (0.42); 7.235 (0.4); 7.2342 (0.37); 7.2334 (0.36); 6.9972 (1.04); 3.4954 (0.62); 3.3334 (2.82); 3,3134 (7.05); 3,2924 (7,11); 3.2724 (2.95); 2,0065 (4,84); 1.0509 (1.6); 1.0382 (3.54); 1.0308 (5); 1.0258 (2.89); 1.0181 (9.87); 1.0108 (6.1); 1,0056 (6,36); 0.998 (10.45); 0.991 (2.94); 0.9855 (6); 0.978 (4.34); 0.9654 (2.19); 0.6018 (2.95); 0.5931 (3.92); 0.5896 (4.37); 0.5806 (10.36); 0.5718 (7.82); 0.5688 (7.26); 0.5673 (7.47); 0.5595 (8.59); 0.5575 (7.86); 0.5514 (5); 0.5467 (5.83); 0.5368 (5.23); 0.4868 (3.8); 0.476 (6.02); 0.473 (5.9); 0.4666 (4.43); 0.4622 (7.93); 0.4557 (7.7); 0.4528 (7.61); 0.4508 (5.62); 0.4416 (11.14); 0.4383 (6.12); 0.4349 (4.86); 0.4304 (4.6); 0.4246 (6.85); 0.421 (6.58); 0.415 (8.63); 0.4109 (4.81); 0.4022 (13.33); 0.3918 (11.99); 0.3891 (8.96); 0.3849 (8.61); 0.3792 (7.43); 0.376 (8.08); 0.371 (11.26); 0.3629 (10.11); 0.3588 (5.94); 0.3498 (7.54); 0.3403 (4.09); 0.327 (2.11); 0.0495 (0.38); 0.0082 (1.65); 0 (60,44);
Verbindung Nr.1760, Lösungsmittel: [DMSO], 400 MHz Compound No. 1760, solvent: [DMSO], 400 MHz
12,6667 (1 ,42); 12,6321 (0,74); 7,9501 (3,49); 7,8416 (2,08); 4,2547 (6,73); 4,0786 (3,51); 3,692 (16); 3,6253 (9,73); 3,3395 (7,36); 3,1678 (0,83); 2,9968 (8,75); 2,9052 (15,5); 2,6703 (0,59); 2,5237 (1,54); 2,519 (2,35); 2,5104 (32,37); 2,5058 (70,23); 2,5011 (97,68); 2,4965 (68,11); 2,4919 (30,19); 2,328 (0,58); -0,0002 (5,74); Verbindung Nr.1744, Lösungsmittel: [DMSO], 400 MHz 12, 6667 (1, 42); 12.6321 (0.74); 7.9501 (3.49); 7.8416 (2.08); 4.2547 (6.73); 4.0786 (3.51); 3,692 (16); 3.6253 (9.73); 3.3395 (7.36); 3.1687 (0.83); 2.9968 (8.75); 2,9052 (15.5); 2,6703 (0.59); 2.5237 (1.54); 2,519 (2.35); 2,5104 (32,37); 2,5058 (70,23); 2.5011 (97.68); 2,4965 (68.11); 2,4919 (30,19); 2.328 (0.58); -0,0002 (5.74); Compound No. 1744, solvent: [DMSO], 400 MHz
12,6022 (2,04); 12,5494 (1,06); 7,9287 (3,24); 7,8172 (1,13); 5,2344 (1,23); 5,2224 (1,11); 4,365 (0,75); 4,353 (0,78); 4,203 (1,09); 4,199 (1,03); 4,1852 (3,67); 4,1813 (3,21); 4,1763 (0,74); 4,1674 (3,9); 4,1636 (3,13); 4,1582 (1,48); 4,1495 (1,33); 4,146 (1,04); 4,1403 (1,43); 4,1365 (0,78); 4,1224 (0,55); 4,1185 (1,52); 4,1007 (1,38);  12, 6022 (2.04); 12.5494 (1.06); 7,9287 (3,24); 7.8172 (1.13); 5.2344 (1.23); 5.2224 (1.11); 4,365 (0.75); 4,353 (0.78); 4,203 (1.09); 4,199 (1.03); 4,1852 (3,67); 4,1813 (3,21); 4,1763 (0.74); 4,1674 (3,9); 4,1636 (3,13); 4,1582 (1.48); 4.140 (1.33); 4.146 (1.04); 4.1403 (1.43); 4.1365 (0.78); 4,1224 (0.55); 4.1185 (1.52); 4,1007 (1,38);
4,0916 (0,65); 4,0739 (0,66); 3,3452 (49,88); 3,3109 (1 ,59); 3,1808 (0,57); 3,1678 (0,89); 3,1563 (0,79); 3,1492 (0,8); 2,675 (0,72); 2,6703 (0,98); 2,6657 (0,7); 2,5238 (2,88); 2,5191 (4,05); 2,5104 (53,76); 2,5058 (116,61); 2,5012 (162,08); 2,4966 (113,24); 2,492 (50,12); 2,4718 (0,61); 2,4672 (0,99); 2,4624 (1,02); 2,4558 (1,44); 2,4512 (1,68); 2,4466 (1,14); 2,4421 (0,52); 2,3327 (0,69); 2,328 (0,97); 2,3234 (0,68); 2,1858 (0,67); 2,1556 (0,68); 2,0735 (0,63); 1,6969 (1,61); 1,6719 (2,09); 1,6439 (0,73); 1,5403 (0,77); 1,4344 (0,53); 1,4024 (0,61); 1,3904 (0,54); 1,3652 (0,71); 4.0916 (0.65); 4.0739 (0.66); 3,3452 (49,88); 3,3109 (1, 59); 3.188 (0.57); 3.1687 (0.89); 3.1563 (0.79); 3.1492 (0.8); 2,675 (0.72); 2,6703 (0.98); 2.6657 (0.7); 2,5238 (2,88); 2.5191 (4.05); 2.5104 (53.76); 2,5058 (116.61); 2.5012 (162.08); 2,4966 (113,24); 2,492 (50.12); 2.4718 (0.61); 2.4672 (0.99); 2.4624 (1.02); 2.4558 (1.44); 2.4512 (1.68); 2.4466 (1.14); 2.4421 (0.52); 2.3327 (0.69); 2,328 (0.97); 2.3234 (0.68); 2.1858 (0.67); 2.1556 (0.68); 2.0735 (0.63); 1.6969 (1.61); 1.6719 (2.09); 1.6439 (0.73); 1.5403 (0.77); 1.4344 (0.53); 1.4024 (0.61); 1.3904 (0.54); 1.3652 (0.71);
1,3381 (0,63); 1,3208 (0,56); 1,303 (0,64); 1,2852 (0,68); 1,2819 (0,68); 1,251 (7,56); 1,2333 (16); 1,2155(7,23); 1,2089(4,57); 1,1911 (9,37); 1,1734 (4,2); -0,0002 (12,43); Verbindung Nr.1759, Lösungsmittel: [DMSO], 400 MHz 1.3381 (0.63); 1.3208 (0.56); 1.303 (0.64); 1.2852 (0.68); 1.2819 (0.68); 1.251 (7.56); 1,2333 (16); 1.2155 (7.23); 1.2089 (4.57); 1,1911 (9,37); 1.1734 (4.2); -0,0002 (12,43); Compound No. 1759, solvent: [DMSO], 400 MHz
12,3685 (6,98); 8,0101 (8,23); 7,4186 (0,79); 7,2856 (7,55); 7,2666 (16); 7,2191 (3,15); 7,2018 (3,77); 3,3721 (0,87); 3,345 (27,53); 3,3183 (275,19); 3,2846 (1,77); 3,2677 (1,76); 3,169 (0,93); 2,6752 (1,48); 2,6705 (2,03); 2,6659 (1,42); 2,5326 (0,71); 2,524 (5,3); 2,5193 (8,13); 2,5106 (121,54); 2,506 (265,32); 2,5014 (371,76); 2,4968  12.3685 (6.98); 8.0101 (8.23); 7.4186 (0.79); 7.2856 (7.55); 7.2666 (16); 7.2191 (3.15); 7,2018 (3,77); 3.371 (0.87); 3,345 (27.53); 3,3183 (275,19); 3.2846 (1.77); 3,2677 (1.76); 3.169 (0.93); 2.6752 (1.48); 2.6705 (2.03); 2.6659 (1.42); 2.5326 (0.71); 2,524 (5.3); 2,5193 (8,13); 2,5106 (121.54); 2,506 (265.32); 2.504 (371.76); 2.4968
(257,76); 2,4922 (112,48); 2,4723 (1,26); 2,4677 (1,5); 2,4632 (0,85); 2,4555 (0,94); 2,4507 (1,6); 2,4462 (1,49); 2,3329 (1,45); 2,3282 (2,05); 2,3237 (1,64); 2,0735 (1,31); 0,0079 (0,73); -0,0002 (26,08); -0,0085 (0,74); Verbindung Nr.1429, Lösungsmittel: [DMSO], 400 MHz  (257.76); 2,4922 (112,48); 2,4723 (1.26); 2.4677 (1.5); 2.4632 (0.85); 2,4555 (0.94); 2.4507 (1.6); 2.4462 (1.49); 2.3329 (1.45); 2.3282 (2.05); 2.3237 (1.64); 2.0735 (1.31); 0.0079 (0.73); -0,0002 (26.08); -0.0085 (0.74); Compound No. 1429, solvent: [DMSO], 400 MHz
12,3898 (4,34); 8,0289 (5,63); 7,4321 (0,59); 7,3011 (1,81); 7,2808 (5,98); 7,2643 (16); 12.3898 (4.34); 8.0289 (5.63); 7.4321 (0.59); 7.3011 (1.81); 7.2808 (5.98); 7,2643 (16);
7,2167 (2,19); 7,2009 (2,51 ); 3,349 (22,41 ); 3,3181 (110,81 ); 3,1894 (0,54); 2,67557.2167 (2.19); 7.2009 (2.51); 3,349 (22.41); 3,3181 (110,81); 3.1894 (0.54); 2.6755
(0,75); 2,6709 (1,06); 2,6663 (0,76); 2,5411 (0,61); 2,5243 (3,17); 2,5196 (4,85); (0.75); 2.6709 (1.06); 2.6663 (0.76); 2.5411 (0.61); 2,5243 (3,17); 2.5196 (4.85);
2,5109 (58,69); 2,5064 (124,7); 2,5018 (171,94); 2,4972 (120,81); 2,4927 (54,65); 2,4691 (0,61 ); 2,4567 (0,57); 2,4519 (0,56); 2,3332 (0,74); 2,3286 (1 ,04); 2,324 (0,74); 2.5109 (58.69); 2.5064 (124.7); 2.5018 (171.94); 2.4972 (120.81); 2,4927 (54,65); 2.4691 (0.61); 2.4567 (0.57); 2.4519 (0.56); 2.3332 (0.74); 2,3286 (1, 04); 2.324 (0.74);
2,0738 (6,83); 0,008 (1,39); -0,0002 (41,66); -0,0086 (1,25); 2.0738 (6.83); 0.008 (1.39); -0.0002 (41.66); -0.0086 (1.25);
Verbindung Nr.1414, Lösungsmittel: [DMSO], 400 MHz Compound No. 1414, solvent: [DMSO], 400 MHz
12,5934 (0,87); 7,9437 (2,85); 7,826 (1); 5,2375 (1,3); 5,2264 (1,15); 4,41 (0,51); 4,374 (0,76); 4,3627 (0,83); 4,2059 (1,03); 4,2017 (1 ,07); 4,188 (3,41); 4,184 (3,27); 4,1701 (3,64); 4,1663 (3,27); 4,1632 (1,73); 4,157 (0,53); 4,1523 (1,25); 4,1485 (1,13); 4,1452 (1,48); 4,1405 (0,68); 4,1272 (0,53); 4,1229 (1,51); 4,1052 (1,4); 4,0961 (0,67); 4,0783 (0,68); 3,3226 (40,15); 3,1853 (0,58); 3,16 (0,82); 3,1532 (0,82); 2,5257 (0,66); 2,521 (0,97); 2,5123 (12,82); 2,5078 (27,71); 2,5032 (38,53); 2,4986 (26,92); 2,494 (11,99); 2,189 (0,7); 2,1559 (0,7); 2,0746 (0,94); 1,7023 (1,76); 1,6906 (1,49); 1,6766 (2,23); 1,6579 (1,06); 1,6481 (0,73); 1,6428 (0,79); 1,634 (0,5); 1,5772 (0,51); 1,5452 (0,78); 1,436 (0,58); 1,4036 (0,7); 1,3938 (0,65); 1,3708 (0,81); 1,3627 (0,74); 1,3454 (0,65); 1 ,3208 (0,53); 1 ,2863 (0,71 ); 1 ,2534 (7,71 ); 1 ,2357 (16); 1 ,2179 (7,31 ); 1 ,2105 (4,6); 1,1927 (9,44); 1,175 (4,24); -0,0002 (12,05);  12.5934 (0.87); 7.9437 (2.85); 7,826 (1); 5.2375 (1.3); 5.2264 (1.15); 4.41 (0.51); 4,374 (0.76); 4.3627 (0.83); 4,2059 (1.03); 4,2017 (1, 07); 4,188 (3.41); 4,184 (3,27); 4,1701 (3,64); 4,1663 (3:27); 4.1632 (1.73); 4.157 (0.53); 4,1523 (1,25); 4.1485 (1.13); 4.1452 (1.48); 4.140 (0.68); 4.1272 (0.53); 4,1229 (1.51); 4,1052 (1.4); 4.0961 (0.67); 4.0783 (0.68); 3,3226 (40,15); 3.1853 (0.58); 3.16 (0.82); 3.1532 (0.82); 2.5257 (0.66); 2,521 (0.97); 2.5123 (12.82); 2.5078 (27.71); 2.5032 (38.53); 2.4986 (26.92); 2,494 (11.99); 2,189 (0.7); 2.1559 (0.7); 2.0746 (0.94); 1.7023 (1.76); 1.6906 (1.49); 1.6766 (2.23); 1.6579 (1.06); 1.6481 (0.73); 1.6428 (0.79); 1,634 (0.5); 1.5772 (0.51); 1.5452 (0.78); 1,436 (0.58); 1.4036 (0.7); 1.3938 (0.65); 1.3708 (0.81); 1.3627 (0.74); 1.3454 (0.65); 1, 3208 (0.53); 1, 2863 (0.71); 1, 2534 (7.71); 1, 2357 (16); 1, 2179 (7,31); 1, 2105 (4,6); 1,1927 (9.44); 1,175 (4.24); -0,0002 (12.05);
Verbindung Nr.1430, Lösungsmittel: [DMSO], 400 MHz Compound No. 1430, solvent: [DMSO], 400 MHz
12,6611 (1 ,57); 12,62 (0,81 ); 7,9667 (2,97); 7,8518 (1 ,72); 4,2585 (6,39); 4,0837 (3,19); 3,6932 (16); 3,6262 (9,49); 3,321 (36,53); 2,997 (8,57); 2,9043 (14,86); 2,5241 (1,23); 2,5193 (1,86); 2,5107 (27,45); 2,5061 (60,41); 2,5015 (84,12); 2,4969 (58,33); 2,4923 (25,83); 0,0081 (0,77); -0,0002 (26,39); -0,0085 (0,75); 12, 6611 (1, 57); 12.62 (0.81); 7.9667 (2.97); 7,8518 (1, 72); 4,2585 (6,39); 4.0837 (3.19); 3,6932 (16); 3.6262 (9.49); 3,321 (36.53); 2,997 (8.57); 2.9043 (14.86); 2.5241 (1.23); 2.5193 (1.86); 2,5107 (27,45); 2.5061 (60.41); 2.5015 (84.12); 2,4969 (58,33); 2,4923 (25,83); 0.0081 (0.77); -0.0002 (26.39); -0.0085 (0.75);
Verbindung Nr.1304, Lösungsmittel: [DMSO], 400 MHz Compound No. 1304, solvent: [DMSO], 400 MHz
12,6305 (2,24); 12,5773 (1 ,45); 7,95 (2,75); 7,8344 (1 ,01 ); 5,2351 (1 ,31 ); 4,444 (0,58); 4,359 (0,91); 4,2031 (1,11); 4,1853 (3,71); 4,1812 (3,07); 4,1675 (3,95); 4,1636 (2,93); 4,1586 (1,5); 4,1499 (1,34); 4,1408 (1,34); 4,1154 (1,43); 4,0978 (1,51); 4,0881 (0,68); 4,0709 (0,73); 3,3746 (1,5); 3,3233 (286,83); 3,2736 (2,27); 3,1672 (3,68); 3,1507 (0,83); 2,6747 (1,4); 2,6701 (1,88); 2,6654 (1,49); 2,5566 (1,19); 2,5519 (1 ,24); 2,5404 (0,96); 2,5237 (4,12); 2,5189 (6,1); 2,5102 (108,85); 2,5056 (240,21); 2,501 (335,73); 2,4964 (234,64); 2,4918 (103,77); 2,4556 (2,09); 2,451 (2,81); 2,4462 (2,1); 2,3326 (1,42); 2,3279 (1,91); 2,3232 (1,39); 2,1885 (0,71); 2,1499 (0,74); 2,0733 (1,16); 12.6305 (2.24); 12.5773 (1, 45); 7.95 (2.75); 7, 8344 (1, 01); 5,2351 (1, 31); 4,444 (0.58); 4.359 (0.91); 4,2031 (1.11); 4,1853 (3.71); 4,1812 (3,07); 4,1675 (3.95); 4.1636 (2.93); 4.1586 (1.5); 4,1499 (1,34); 4,1408 (1,34); 4.1154 (1.43); 4.0978 (1.51); 4.0881 (0.68); 4.0709 (0.73); 3.3746 (1.5); 3,3233 (286,83); 3.2736 (2.27); 3,1672 (3,68); 3.1507 (0.83); 2.6747 (1.4); 2,6701 (1.88); 2.6654 (1.49); 2.5566 (1.19); 2.5519 (1, 24); 2.5404 (0.96); 2,5237 (4,12); 2.5189 (6.1); 2,5102 (108.85); 2,5056 (240,21); 2,501 (335.73); 2,4964 (234,64); 2.4918 (103.77); 2.4556 (2.09); 2,451 (2.81); 2.4462 (2.1); 2.3326 (1.42); 2.3279 (1.91); 2.3232 (1.39); 2,1885 (0.71); 2,1499 (0.74); 2.0733 (1.16);
1,6973 (1,63); 1,6709 (2,06); 1,5328 (0,82); 1,3992 (0,72); 1,3634 (0,84); 1,2844 (0,79); 1,2507 (7,45); 1,233 (16); 1,2152 (7,19); 1,2092 (4,89); 1,1914(9,87); 1,1736 (4,39); 0,008 (3,05); -0,0002 (112,88); -0,0085 (3,45); -0,0503 (1 ,04); 1.6973 (1.63); 1.6709 (2.06); 1.5328 (0.82); 1.3992 (0.72); 1.3634 (0.84); 1.2844 (0.79); 1,2507 (7.45); 1,233 (16); 1.2152 (7.19); 1,2092 (4,89); 1.1914 (9.87); 1.1736 (4.39); 0.008 (3.05); -0.0002 (112.88); -0.0085 (3.45); -0.0503 (1, 04);
Verbindung Nr.112, Lösungsmittel: [DMSO], 400 MHz Compound No.112, solvent: [DMSO], 400 MHz
13,0274 (1,41); 8,2688 (10,45); 3,3672 (2,14); 3,3528 (2,87); 3,3491 (6,77); 3,3391 (3,28); 3,335 (7,71); 3,3311 (7,95); 3,3212 (3,67); 3,317 (7,61); 3,3133 (3,59); 3,3032 (1 ,48); 3,299 (2,6); 2,525 (0,43); 2,5204 (0,61 ); 2,5116 (15,72); 2,507 (35,22); 2,5024 (50); 2,4978 (35,4); 2,4933 (16,12); 2,3568 (12,34); 2,3513 (12,48); 2,3294 (0,63); 2,0864 (0,41); 1,2335 (0,37); 1,1581 (1,09); 1,151 (14,93); 1,1399 (2,35); 1,133 (31 ,76); 1 ,1217 (1 ,41 ); 1 ,115 (14,55); -0,0002 (0,91 ); Verbindung Nr.552, Lösungsmittel: [DMSO], 400 MHz  13.0274 (1.41); 8.2688 (10.45); 3,3672 (2,14); 3.3528 (2.87); 3,3491 (6.77); 3,3391 (3,28); 3,335 (7.71); 3.3311 (7.95); 3.3212 (3.67); 3,317 (7.61); 3,3133 (3.59); 3,3032 (1, 48); 3,299 (2.6); 2,525 (0.43); 2.5204 (0.61); 2.5116 (15.72); 2,507 (35,22); 2.5024 (50); 2.4978 (35.4); 2,4933 (16,12); 2.3568 (12.34); 2,3513 (12,48); 2.3294 (0.63); 2.0864 (0.41); 1.2335 (0.37); 1.1581 (1.09); 1,151 (14.93); 1.1399 (2.35); 1,133 (31, 76); 1, 1217 (1, 41); 1, 115 (14.55); -0,0002 (0.91); Compound No. 552, solvent: [DMSO], 400 MHz
8,3079 (1 ,3); 3,409 (0,4); 3,3612 (50); 3,3393 (1 ,6); 3,3355 (1 ,38); 3,3211 (1 ,03); 2,7 (0,42); 2,6797 (0,45); 2,5138 (3,11); 2,5094 (6,86); 2,5048 (9,58); 2,5003 (6,8); 2,4958 (3,05); 1,1932 (1,03); 1,1745(2,2); 1,1545 (2,35); 1,1362 (3,39); 1,1181 (1,54);- 0,0002 (0,7);  8,3079 (1, 3); 3.409 (0.4); 3,3612 (50); 3,3393 (1, 6); 3,3355 (1, 38); 3,3211 (1, 03); 2.7 (0.42); 2.6797 (0.45); 2,5138 (3,11); 2.5094 (6.86); 2.5048 (9.58); 2,5003 (6.8); 2.4958 (3.05); 1.1932 (1.03); 1.1745 (2.2); 1.1545 (2.35); 1.1362 (3.39); 1.1181 (1.54); - 0.0002 (0.7);
Verbindung Nr.445, Lösungsmittel: [CDCI3], 400 MHz Compound No.445, solvent: [CDCl3], 400 MHz
9,4566 (0,52); 8,4679 (3,52); 7,2604 (47,18); 7,2597 (50); 3,0201 (0,5); 3,0101 (0,59); 3,0019 (1,03); 2,9918 (1,07); 2,9836 (0,59); 2,9736 (0,52); 2,3725 (3,77); 2,3665 (7,99); 2,3603 (4,12); 1,552 (0,83); 0,8935 (0,69); 0,8795 (1,65); 0,8758 (2,34); 0,8626 (2,28); 0,8578 (1 ,84); 0,8448 (0,92); 0,6536 (0,82); 0,6435 (1 ,66); 0,6406 (1 ,76); 9.4566 (0.52); 8,4679 (3,52); 7.2604 (47.18); 7,2597 (50); 3.0201 (0.5); 3.0101 (0.59); 3.0019 (1.03); 2.9918 (1.07); 2.9836 (0.59); 2.9736 (0.52); 2.3725 (3.77); 2.3665 (7.99); 2,3603 (4,12); 1,552 (0.83); 0.8935 (0.69); 0.8795 (1.65); 0.8758 (2.34); .8626 (2.28); 0.8578 (1, 84); 0.8448 (0.92); 0.6536 (0.82); 0.6435 (1, 66); 0.6406 (1, 76);
0,6369 (1 ,71 ); 0,6307 (1 ,76); 0,6269 (1 ,65); 0,6133 (0,64); 0,0005 (1 1 ,23); -0,0002 (1 1 ,34); -0,0077 (0,36); Verbindung Nr. 476, Lösungsmittel: [DMSO], 400 MHz 0.6369 (1, 71); 0.6307 (1, 76); 0.6269 (1, 65); 0.6133 (0.64); 0.0005 (1 1, 23); -0,0002 (1 1, 34); -0.0077 (0.36); Compound No. 476, solvent: [DMSO], 400 MHz
13,0388 (0,79); 8,2434 (5,53); 4,1403 (0,31 ); 4,1 19 (0,63); 4,1037 (0,88); 4,0879 (0,67); 4,0668 (0,32); 3,3383 (40,8); 2,5261 (0,44); 2,5125 (16,29); 2,5082 (36,06); 2,5037 (50); 2,4993 (35,83); 2,4951 (16,59); 2,3753 (6); 2,3305 (0,37); 1 ,652 (0,38); 1 ,6355 (0,71 ); 1 ,6158 (0,88); 1 ,5995 (0,85); 1 ,583 (0,54); 1 ,5067 (0,67); 1 ,492 (0,56); 1 ,4841 (0,7); 1 ,4724 ( ,1 1 ); ,4583 (0,81 ); 1 ,4504 (0,94); 1 ,4358 (0,75); 1 ,3126 (0,98); 1 ,2988 (1 ,06); 1 ,2918 (0,95); 1 ,2783 (1 ,57); 1 ,2648 (0,75); 1 ,258 (0,72); 1 ,2441 (0,66); 1 ,1485 (9,94); 1 ,1321 (9,88); 0,8876 (19,3); 0,871 1 (19,03); 0,0008 (5,94); -0,0002 (6,66); Verbindung Nr. 221 , Lösungsmittel: [DMSO], 400 MHz  13.0388 (0.79); 8.2434 (5.53); 4.1403 (0.31); 4.1 19 (0.63); 4.1037 (0.88); 4.0879 (0.67); 4.0668 (0.32); 3,3383 (40,8); 2.5261 (0.44); 2.5125 (16.29); 2,5082 (36.06); 2,5037 (50); 2.4993 (35.83); 2.4951 (16.59); 2,3753 (6); 2.3305 (0.37); 1, 652 (0.38); 1, 6355 (0.71); 1, 6158 (0.88); 1, 5995 (0.85); 1, 583 (0.54); 1, 5067 (0.67); 1, 492 (0.56); 1, 4841 (0.7); 1, 4724 (, 11); , 4583 (0.81); 1, 4504 (0.94); 1, 4358 (0.75); 1, 3126 (0.98); 1, 2988 (1, 06); 1, 2918 (0.95); 1, 2783 (1, 57); 1, 2648 (0.75); 1, 258 (0.72); 1, 2441 (0.66); 1, 1485 (9.94); 1, 1321 (9,88); 0.8876 (19.3); 0.871 1 (19.03); 0.0008 (5.94); -0.0002 (6.66); Compound No. 221, solvent: [DMSO], 400 MHz
12,968 (0,34); 8,7347 (0,35); 8,5995 (0,64); 8,2534 (5,03); 3,678 (1 ,81 ); 3,464 (1 ,9); 2,8409 (8,22); 2,8316 (8,26); 2,8292 (8,62); 2,6721 (0,32); 2,5531 (0,37); 2,5059 (43,69); 2,5031 (50); 2,499 (35,9); 2,3773 (7,2); 2,3303 (0,34); 2,076 (0,46); 0,0025 (0,64); -0,0002 (0,87);  12,968 (0.34); 8.7347 (0.35); 8.5995 (0.64); 8,2534 (5,03); 3,678 (1, 81); 3,464 (1, 9); 2,8409 (8,22); 2,8316 (8,26); 2,8292 (8,62); 2.6721 (0.32); 2.5531 (0.37); 2,5059 (43,69); 2.5031 (50); 2,499 (35.9); 2.3773 (7.2); 2.3303 (0.34); 2.076 (0.46); 0.0025 (0.64); -0.0002 (0.87);
Verbindung Nr. 771 , Lösungsmittel: [DMSO], 400 MHz Compound No. 771, solvent: [DMSO], 400 MHz
13,0386 (0,83); 8,2817 (6,7); 3,3375 (18,09); 2,8459 (10,28); 2,8346 (10,85); 2,7386 (2,31 ); 2,7203 (2,37); 2,6723 (0,43); 2,5033 (50); 2,0761 (0,58); 1 ,2097 (4,54); 1 ,191 (9,28); 1 ,1724 (4,47); 0,002 (2,91 ); -0,0002 (3,26);  13.0386 (0.83); 8,2817 (6,7); 3.3375 (18.09); 2.8459 (10.28); 2.8346 (10.85); 2.7386 (2.31); 2,7203 (2.37); 2.6723 (0.43); 2,5033 (50); 2.0761 (0.58); 1, 2097 (4,54); 1, 191 (9,28); 1, 1724 (4:47); 0.002 (2.91); -0.0002 (3.26);
Verbindung Nr. 777, Lösungsmittel: [DMSO], 400 MHz Compound No. 777, solvent: [DMSO], 400 MHz
13,0215 (0,62); 8,2677 (5,39); 4,4369 (0,57); 4,4165 (1 ,12); 4,3971 (1 ,13); 4,3765 (0,59); 3,3317 (50); 2,7322 (1 ,67); 2,7145 (1 ,72); 2,6958 (0,69); 2,6721 (0,33); 2,5027 (46,72); 2,4988 (36,24); 2,2947 (0,38); 2,2675 (1 ,39); 2,258 (1 ,33); 2,2488 (1 ,47); 2,2283 (0,7); 2,221 1 (0,57); 2,076 (1 ,12); 2,0535 (1 ,3); 2,0301 (1 ,72); 2,003 (1 ,15); 13.0215 (0.62); 8.2677 (5.39); 4,4369 (0.57); 4,4165 (1, 12); 4, 3971 (1, 13); 4.3765 (0.59); 3,3317 (50); 2,7322 (1, 67); 2,7145 (1, 72); 2.6958 (0.69); 2.6721 (0.33); 2.5027 (46.72); 2,4988 (36,24); 2.2947 (0.38); 2.2675 (1, 39); 2.258 (1, 33); 2.2488 (1, 47); 2.2283 (0.7); 2,221 1 (0.57); 2.076 (1, 12); 2.0535 (1, 3); 2,0301 (1, 72); 2,003 (1, 15);
1 ,9793 (0,36); 1 ,741 1 (0,83); 1 ,7274 (1 ,35); 1 ,7172 (1 ,5); 1 ,7065 (1 ,61 ); 1 ,7008 (1 ,86); 1 ,6828 (1 ,12); 1 ,6751 (0,93); 1 ,6566 (0,37); 1 ,2095 (3,39); 1 ,191 (7,1 ); 1 ,1723 (3,34); - 0,0002 (3,77); -0,0019 (3,46); Verbindung Nr.783, Lösungsmittel: [DMSO], 400 MHz 1, 9793 (0.36); 1, 741 1 (0.83); 1, 7274 (1, 35); 1, 7172 (1, 5); 1, 7065 (1, 61); 1, 7008 (1, 86); 1, 6828 (1, 12); 1, 6751 (0.93); 1, 6566 (0.37); 1, 2095 (3.39); 1, 191 (7.1); 1, 1723 (3.34); - 0.0002 (3.77); -0.0019 (3.46); Compound No.783, solvent: [DMSO], 400 MHz
12,8482 (0,77); 8,0788 (8,67); 3,1459 (0,34); 3,0965 (42,3); 2,9793 (4,08); 2,9636 (6,42); 2,948 (4,2); 2,5036 (2,59); 2,4853 (2,66); 2,4676 (1,19); 2,4545 (0,71); 2,4355 (0,88); 2,2657 (50); 2,2621 (38,93); 1,8375 (0,65); 0,9742 (5,55); 0,9556 (11,57);  12.8482 (0.77); 8.0788 (8.67); 3.1459 (0.34); 3.0965 (42.3); 2.9793 (4.08); 2.9636 (6.42); 2,948 (4.2); 2.5036 (2.59); 2.4853 (2.66); 2.4676 (1.19); 2.4545 (0.71); 2.4355 (0.88); 2,2657 (50); 2.2621 (38.93); 1.8375 (0.65); 0.9742 (5.55); 0.9556 (11.57);
0,9369 (5,47); 0,8331 (0,52); 0,8208 (1 ,04); 0,8132 (0,95); 0,8018 (1 ,57); 0,78980.9369 (5.47); 0.8331 (0.52); 0.8208 (1, 04); 0.8132 (0.95); 0.8018 (1, 57); .7898
(0,99); 0,7835 (1,12); 0,7709 (0,63); 0,7482 (0,3); 0,3076 (0,68); 0,2918 (0,64); 0,2405 (1,26); 0,2296 (4,26); 0,2256 (4,47); 0,2152 (1,92); 0,2091 (4,28); 0,2059 (4,23); (0.99); 0.7835 (1.12); 0.7709 (0.63); 0.7482 (0.3); 0.3076 (0.68); 0.2918 (0.64); 0.2405 (1.26); 0.2296 (4.26); 0.2256 (4.47); 0.2152 (1.92); 0,2091 (4,28); 0,2059 (4,23);
0,1959 (1,5); 0,0774 (0,82); 0,0627 (0,92); 0,0507 (0,32); 0,025 (1,52); 0,0129 (5,49); - 0,0002 (5,24); -0,0118 (1,16); -0,2377 (3,96); -0,2395 (4); 0.1959 (1.5); 0.0774 (0.82); 0.0627 (0.92); 0.0507 (0.32); 0.025 (1.52); 0.0129 (5.49); - 0.0002 (5.24); -0.0118 (1.16); -0.2377 (3.96); -0.2395 (4);
Verbindung Nr.793, Lösungsmittel: [DMSO], 400 MHz Compound No.793, solvent: [DMSO], 400 MHz
13,0433 (0,44); 8,2789 (3,27); 3,3815 (1,21); 3,3559 (0,73); 3,3286 (50); 3,3069 (1,38); 3,2781 (1 ,55); 2,7363 (1,15); 2,7179 (1 ,2); 2,6715 (0,4); 2,5577 (1,11); 2,5026 (49,8); 2,4523 (1,51); 2,0755 (0,58); 1,6506 (0,33); 1,6335 (0,68); 1,617 (0,91); 1,6 (0,81); 1 ,5838 (0,47); 1 ,4527 (0,91 ); 1 ,435 (2,18); 1 ,4168 (2,12); 1 ,3995 (0,84); 1 ,2093 (2,17); 1,1907 (4,53); 1,1721 (2,18); 0,9664 (0,34); 0,9132 (12,44); 0,8967 (11,9); 0,874 (0,87); 0,863 (0,39); 0,8465 (0,39); 0,0022 (2,22); -0,0002 (2,91);  13.0433 (0.44); 8,2789 (3:27); 3.3815 (1.21); 3.3559 (0.73); 3,3286 (50); 3.3069 (1.38); 3,2781 (1, 55); 2,7363 (1.15); 2,7179 (1, 2); 2.6715 (0.4); 2.5577 (1.11); 2.506 (49.8); 2.4523 (1.51); 2.0755 (0.58); 1.6506 (0.33); 1.6335 (0.68); 1,617 (0.91); 1.6 (0.81); 1, 5838 (0.47); 1, 4527 (0.91); 1, 435 (2:18); 1,4168 (2,12); 1, 3995 (0.84); 1, 2093 (2,17); 1.1907 (4.53); 1.1721 (2.18); 0.9664 (0.34); 0.9132 (12.44); 0.8967 (11.9); 0.874 (0.87); 0.863 (0.39); 0.8465 (0.39); 0.0022 (2.22); -0,0002 (2.91);
Verbindung Nr.795, Lösungsmittel: [DMSO], 400 MHz Compound No.795, solvent: [DMSO], 400 MHz
9,0032 (0,34); 8,3124 (7,83); 8,1074 (0,66); 5,9531 (0,51); 5,9403 (1,12); 5,9273 (1,08); 5,9188 (0,71); 5,9145 (1,28); 5,9128 (1,29); 5,8955 (1,59); 5,8843 (1,23); 9.0032 (0.34); 8.3124 (7.83); 8,1074 (0.66); 5.9531 (0.51); 5.9403 (1.12); 5.9273 (1.08); 5.9188 (0.71); 5.9145 (1.28); 5.9128 (1.29); 5.8955 (1.59); 5.8843 (1.23);
5,8773 (1,09); 5,8715 (1,38); 5,8587 (0,74); 5,8508 (0,78); 5,8358 (0,37); 5,4019 (1,55); 5,4006 (1,53); 5,3586 (1,31); 5,326 (1,52); 5,3241 (1,71); 5,2998 (1,41); 5,2979 (1,59); 5,2315 (2,3); 5,229 (2,37); 5,1902 (1,91); 5,1884 (2,01); 5,186 (2,06); 5,1342 (2,24); 5,1324 (2,48); 5,1303 (2,39); 5,1084 (2,1 ); 5,1067 (2,3); 5,1045 (2,24); 3,9707 (2,59); 3,9573 (4,89); 3,9441 (2,65); 3,6691 (13,41); 3,473 (0,62); 3,4582 (1,65); 5.8773 (1.09); 5.8715 (1.38); 5.8887 (0.74); 5.8508 (0.78); 5.8358 (0.37); 5.4019 (1.55); 5,4006 (1.53); 5.3586 (1.31); 5.326 (1.52); 5.3241 (1.71); 5.2998 (1.41); 5.2979 (1.59); 5.2315 (2.3); 5.299 (2.37); 5.1902 (1.91); 5.1884 (2.01); 5.186 (2.06); 5,1342 (2.24); 5.134 (2.48); 5,1303 (2.39); 5,1084 (2,1); 5,1067 (2,3); 5,1045 (2.24); 3.9707 (2.59); 3,9573 (4,89); 3.9441 (2.65); 3,6691 (13,41); 3,473 (0.62); 3.4582 (1.65);
3,4436 (2,38); 3,4292 (1,63); 3,4146 (0,52); 2,7587 (0,93); 2,7398 (2,78); 2,7213 (2,86); 2,7029 (1,04); 2,6741 (0,32); 2,5083 (38,65); 2,5055 (50); 2,5014 (38,46); 3.4436 (2.38); 3.4292 (1.63); 3.4146 (0.52); 2,7587 (0.93); 2,7398 (2.78); 2.7213 (2.86); 2.7029 (1.04); 2.6741 (0.32); 2.5083 (38.65); 2,5055 (50); 2.504 (38.46);
2,3315 (0,3); 2,0771 (0,48); 2,0753 (0,44); 1,7615 (1,1); 1,7599 (1,08); 1,2106 (5,53); 1 ,192 (11 ,74); 1 ,1733 (5,48); -0,0002 (2,42); -0,0019 (2,08); 2.3315 (0.3); 2.0771 (0.48); 2.0753 (0.44); 1.7615 (1.1); 1.7599 (1.08); 1.2106 (5.53); 1, 192 (11, 74); 1, 1733 (5.48); -0,0002 (2.42); -0.0019 (2.08);
Verbindung Nr.798, Solvent: [DMSO], 400 MHz Compound No. 798, solvent: [DMSO], 400 MHz
12,9867 (0,35); 8,2831 (3,28); 4,1211 (1 ,84); 4,1148 (2,15); 4,1073 (2,24); 4,1013 (1,91); 3,3266 (48,45); 3,2756 (0,34); 3,1791 (1,04); 3,1741 (2,25); 3,1678 (1,14); 2,7396 (1,13); 2,7212 (1,16); 2,703 (0,46); 2,6712 (0,32); 2,5051 (36,99); 2,5017 (50); 2,4977 (38,47); 2,4467 (0,31); 2,0862 (0,46); 2,0751 (0,51); 1,2047 (2,44); 1,1862 (5,17); 1,1675 (2,41); -0,0002 (3,28); -0,0018 (2,87); Verbindung Nr.222, Lösungsmittel: [DMSO], 400 MHz 12.9867 (0.35); 8,2831 (3,28); 4,1211 (1, 84); 4,1148 (2,15); 4,1073 (2.24); 4.1013 (1.91); 3,3266 (48.45); 3.2756 (0.34); 3.1791 (1.04); 3,1741 (2.25); 3,1678 (1.14); 2,7396 (1.13); 2.7212 (1.16); 2,703 (0.46); 2.6712 (0.32); 2,5051 (36.99); 2.5017 (50); 2,4977 (38,47); 2.4467 (0.31); 2.0862 (0.46); 2.0751 (0.51); 1,2047 (2.44); 1,1862 (5:17); 1.1675 (2.41); -0.0002 (3.28); -0.0018 (2.87); Compound No. 222, solvent: [DMSO], 400 MHz
8,2559 (1,03); 3,3364 (27,06); 2,5511 (0,36); 2,5062 (37,48); 2,5029 (50); 2,499 (38,89); 2,3777 (1,27); 2,3301 (0,31); 1,1486 (1,01); 1,1306 (1,99); 1,1126 (0,95); 0,0013 (2,83); -0,0002 (2,87); Verbindung Nr.222, Lösungsmittel: [DMSO], 400 MHz  8.2559 (1.03); 3,3364 (27.06); 2.5511 (0.36); 2.5062 (37.48); 2.509 (50); 2,499 (38.89); 2.3777 (1.27); 2.3301 (0.31); 1.186 (1.01); 1.1306 (1.99); 1.1126 (0.95); 0.0013 (2.83); -0,0002 (2,87); Compound No. 222, solvent: [DMSO], 400 MHz
8,2487 (0,88); 3,6615 (0,34); 3,4433 (50); 3,3638 (0,53); 3,3461 (0,79); 3,3287 (0,82); 3,3138 (0,65); 2,5078 (9,99); 2,3821 (0,86); 2,3749 (1,44); 2,3665 (0,74); 2,071 (0,66); 8.2487 (0.88); 3.6615 (0.34); 3,4433 (50); 3.3638 (0.53); 3.3461 (0.79); 3.3287 (0.82); 3,3138 (0.65); 2.5078 (9.99); 2.3821 (0.86); 2.3749 (1.44); 2.3665 (0.74); 2.071 (0.66);
I, 1483 (0,96); 1,1303(1,95); 1,1122 (0,89); Verbindung Nr.223, Lösungsmittel: [DMSO], 400 MHz I, 1483 (0.96); 1.1303 (1.95); 1.1122 (0.89); Compound No. 223, solvent: [DMSO], 400 MHz
8,2515 (1,84); 3,6604 (0,37); 3,375 (50); 3,2947 (1,27); 3,2779 (1,67); 3,2618 (1,56); 3,2452 (0,8); 2,5046 (31,98); 2,3776 (2,61); 2,0747 (0,57); 1,5642 (0,58); 1,5463 (1,17); 1,5282 (1,21); 1,5101 (0,63); 1,081 (0,43); 0,915 (1,78); 0,8965 (3,5); 0,878 (1,55); 0,0016 (1,8); -0,0002 (2,07);  8.2515 (1.84); 3.6604 (0.37); 3,375 (50); 3.2947 (1.27); 3.2779 (1.67); 3.2618 (1.56); 3.2452 (0.8); 2.5046 (31.98); 2.3776 (2.61); 2.0747 (0.57); 1.5642 (0.58); 1.5463 (1.17); 1.5282 (1.21); 1.5101 (0.63); 1.081 (0.43); 0.915 (1.78); 0.8965 (3.5); 0.878 (1.55); 0.0016 (1.8); -0,0002 (2.07);
Verbindung Nr.224, Lösungsmittel: [DMSO], 400 MHz Compound No.224, solvent: [DMSO], 400 MHz
13,0023 (0,37); 8,6127 (0,33); 8,5562 (1,59); 8,275 (6,18); 8,1862 (0,37); 4,1384 (0,34); 4,1216 (0,93); 4,1051 (1,42); 4,0865 (1,48); 4,07 (0,99); 4,0533 (0,37); 3,8559 (2,28); 3,61 (3,3); 3,3468 (13,49); 2,5301 (0,49); 2,5165 (15,05); 2,512 (34,71); 2,5074 (50); 2,5028 (36,11 ); 2,4982 (16,7); 2,3893 (4,39); 2,3812 (8,23); 2,3725 (4,44); 2,3343 (0,33); 2,0782 (0,89); 1,1942 (29,69); 1,1874(10,73); 1,1777(29,95); 1,1711 (10,29);  13,0023 (0.37); 8.6127 (0.33); 8.5562 (1.59); 8,275 (6:18); 8, 1862 (0.37); 4.1384 (0.34); 4,1216 (0.93); 4,1051 (1.42); 4.0865 (1.48); 4.07 (0.99); 4.0533 (0.37); 3.8559 (2.28); 3.61 (3.3); 3,3468 (13,49); 2,5301 (0.49); 2.5165 (15.05); 2,512 (34.71); 2,5074 (50); 2.5028 (36.11); 2.4982 (16.7); 2,3893 (4.39); 2,3812 (8,23); 2.3725 (4.44); 2.3343 (0.33); 2.0782 (0.89); 1.1942 (29.69); 1.1874 (10.73); 1.1777 (29.95); 1.1711 (10.29);
Verbindung Nr.225, Lösungsmittel: [DMSO], 400 MHz Compound No. 225, solvent: [DMSO], 400 MHz
II, 133 (0,61); 7,8959 (6,09); 3,33 (2,14); 2,832 (0,6); 2,8222 (0,88); 2,8139 (1,35); 2,8038 (1 ,4); 2,7953 (0,96); 2,7856 (0,7); 2,5465 (0,75); 2,5354 (1 ,08); 2,5285 (1 ,23); II, 133 (0.61); 7,8959 (6.09); 3.33 (2.14); 2,832 (0.6); 2.8222 (0.88); 2.8139 (1.35); 2,8038 (1, 4); 2,7953 (0.96); 2,7856 (0.7); 2.5465 (0.75); 2,5354 (1, 08); 2.5285 (1, 23);
2,5271 (1,31); 2,5187 (3,25); 2,511 (15,64); 2,5064 (34,22); 2,5017 (50); 2,4971 (35,68); 2,4925 (17,34); 2,3286 (0,31); 2,2192 (5,41); 2,2101 (11,43); 2,2009 (6,18); 2,0728 (0,96); 0,7214 (1,28); 0,709 (3,51); 0,704 (4,48); 0,6914 (4,34); 0,6863 (3,86); 0,6744 (2,21); 0,6574 (1,73); 0,6546 (3,46); 0,6519 (2,7); 0,6484 (3,68); 0,6439 (2,84); 0,6368 (3,53); 0,6312 (7,49); 0,6272 (6,48); 0,6239 (3,25); 0,6206 (6,04); 0,6167 (5,46); 0,6146 (3,33); 0,6112 (3,67); 0,6008 (0,78); 0,5897 (0,47); 0,452 (1,5); 0,4406 (4,05); 0,4355 (3,87); 0,4303 (3,79); 0,4255 (4,02); 0,4135 (1,43); Verbindung Nr.226, : Lösungsmittel: [DMSO], 400 MHz 2.5271 (1.31); 2.5187 (3.25); 2,511 (15,64); 2.5064 (34.22); 2.5017 (50); 2.4971 (35.68); 2.4925 (17.34); 2.3286 (0.31); 2.2192 (5.41); 2.2101 (11.43); 2,2009 (6,18); 2.0728 (0.96); 0.7214 (1.28); 0.709 (3.51); 0.704 (4.48); 0.6914 (4.34); 0.6863 (3.86); 0.6744 (2.21); 0.6574 (1.73); 0.6546 (3.46); 0.6519 (2.7); 0.6484 (3.68); 0.6439 (2.84); 0.6368 (3.53); 0.6312 (7.49); 0.6272 (6.48); 0.6239 (3.25); 0.6206 (6.04); 0.6167 (5.46); 0.6146 (3.33); 0.6112 (3.67); 0.6008 (0.78); 0.5897 (0.47); 0.452 (1.5); 0.4406 (4.05); 0.4355 (3.87); 0.4303 (3.79); 0.4255 (4.02); 0.4135 (1.43); Compound No. 266,: Solvent: [DMSO], 400 MHz
12,992 (0,31); 8,8052 (0,33); 8,5871 (0,46); 8,2755 (5,66); 7,8157 (0,59); 3,6542 (1,38); 3,4157 (4,58); 3,3311 (2,21); 3,3139 (3,94); 3,2988 (3,81); 3,2818 (1,85);  12,992 (0.31); 8,8052 (0.33); 8,5871 (0.46); 8.2755 (5.66); 7.8157 (0.59); 3.6542 (1.38); 3.4157 (4.58); 3.3311 (2.21); 3,3139 (3.94); 3,2988 (3.81); 3.2818 (1.85);
3,1687 (0,35); 2,7867 (0,8); 2,7711 (1,26); 2,75 (1,29); 2,7349 (0,88); 2,5089 (36,4); 2,5048 (50); 2,5005 (37,53); 2,3842 (3,97); 2,3762 (7,43); 2,3678 (4,2); 2,3316 (0,34); 2,0877 (1 ,3); 2,0775 (0,71 ); 1 ,5545 (0,51 ); 1 ,5368 (1 ,31 ); 1 ,5273 (2,31 ); 1 ,5169 (2,45); 1,5095 (3,66); 1,4915 (2,79); 1,4789 (0,9); 1,4722 (0,98); 1,376 (0,52); 1,3703 (0,47); 1,3572 (1,95); 1,3522 (1,69); 1,3377 (3,43); 1,3192 (3,4); 1,3015 (1,82); 1,296 (1,38); 1,2839 (0,48); 1,2776 (0,37); 0,918 (6,19); 0,8998 (12,67); 0,8859 (9,32); 0,8816 (6,14); 0,8676 (3,86); -0,0002 (7,56); 3.1687 (0.35); 2.7867 (0.8); 2.7711 (1.26); 2.75 (1.29); 2.7349 (0.88); 2.5089 (36.4); 2.5048 (50); 2,5005 (37.53); 2.3842 (3.97); 2.372 (7.43); 2.3678 (4.2); 2.3316 (0.34); 2.0877 (1, 3); 2.0775 (0.71); 1, 5545 (0.51); 1, 5368 (1, 31); 1, 5273 (2.31); 1, 5169 (2.45); 1.5095 (3.66); 1.4915 (2.79); 1.4789 (0.9); 1.4722 (0.98); 1.376 (0.52); 1.3703 (0.47); 1.3572 (1.95); 1.3522 (1.69); 1.3377 (3.43); 1.3192 (3.4); 1.3015 (1.82); 1.296 (1.38); 1.2839 (0.48); 1.2776 (0.37); 0.918 (6.19); 0.8998 (12.67); 0.8859 (9.32); 0.8816 (6.14); 0.8676 (3.86); -0,0002 (7.56);
Verbindung Nr.227, Lösungsmittel: [DMSO], 400 MHz Compound No. 227, solvent: [DMSO], 400 MHz
8,6259 (0,33); 8,2521 (2,54); 8,2216 (1,54); 4,434 (0,34); 4,4141 (0,63); 4,3939 (0,64); 4,3728 (0,37); 3,717 (1,7); 3,5604 (2,26); 2,6725 (0,31); 2,5516 (0,82); 2,5032 (50); 2,4992 (39,34); 2,4593 (0,83); 2,3977 (1,24); 2,3888 (2,72); 2,3806 (2,82); 2,3747 (3,53); 2,3659 (1 ,9); 2,3295 (0,37); 2,2608 (0,72); 2,2416 (0,77); 2,2218 (0,41 ); 2,179 (0,39); 2,1559 (0,51); 2,0845 (0,61); 2,0757 (0,68); 2,0592 (1,08); 2,0338 (1,21);  8.6259 (0.33); 8.2521 (2.54); 8.2216 (1.54); 4,434 (0.34); 4,4141 (0.63); 4.3939 (0.64); 4.3728 (0.37); 3.717 (1.7); 3.5604 (2.26); 2.6725 (0.31); 2.5516 (0.82); 2.5032 (50); 2.4992 (39.34); 2,4593 (0.83); 2.3977 (1.24); 2.3888 (2.72); 2.3806 (2.82); 2.3747 (3.53); 2,3659 (1, 9); 2.3295 (0.37); 2.2608 (0.72); 2.2416 (0.77); 2.2218 (0.41); 2,179 (0.39); 2.1559 (0.51); 2.0845 (0.61); 2.0757 (0.68); 2.0592 (1.08); 2.0338 (1.21);
2,0113 (0,7); 1 ,786 (0,42); 1 ,7579 (0,45); 1 ,7367 (0,58); 1 ,724 (0,63); 1 ,7133 (0,82); 1,7036 (0,84); 1,6965 (0,96); 1,679 (0,54); 1,6708 (0,48); -0,0002 (5,17); -0,0019 (4,75); 2.0113 (0.7); 1, 786 (0.42); 1, 7579 (0.45); 1, 7367 (0.58); 1, 724 (0.63); 1, 7133 (0.82); 1.7036 (0.84); 1.6965 (0.96); 1.679 (0.54); 1.6708 (0.48); -0.0002 (5.17); -0.0019 (4.75);
Verbindung Nr.233, Lösungsmittel: [DMSO], 400 MHz Compound No. 233, solvent: [DMSO], 400 MHz
12,7621 (0,64); 8,0452 (5,6); 5,5192 (0,32); 3,1408 (0,32); 3,087 (15,43); 2,9787 (3,2); 2,962 (4,05); 2,9474 (3,28); 2,4355 (0,31); 2,322 (0,36); 2,3175 (0,31); 2,289 (0,34); 2,2844 (0,51); 2,2756 (15,38); 2,271 (35,18); 2,2664 (50); 2,2618 (35,59); 2,2572 (16,07); 2,221 (0,38); 2,2164 (0,53); 2,2118 (0,41); 2,154 (3,39); 2,1457 (6,5); 2,137 (3,61); 2,0977 (0,33); 2,0934 (0,36); 1,8383 (0,5); 0,829 (0,31); 0,8169 (0,65); 0,8116 (0,63); 0,8077 (0,51); 0,7996 (1,22); 0,7914 (0,51); 0,7874 (0,68); 0,7824 (0,66);  12,7621 (0.64); 8.0452 (5.6); 5.5192 (0.32); 3.140 (0.32); 3,087 (15.43); 2.9787 (3.2); 2,962 (4.05); 2.9474 (3.28); 2.4355 (0.31); 2.322 (0.36); 2.3175 (0.31); 2.289 (0.34); 2.2844 (0.51); 2,2756 (15,38); 2,271 (35.18); 2.2664 (50); 2.2618 (35.59); 2.2572 (16.07); 2,221 (0.38); 2.2164 (0.53); 2.2118 (0.41); 2,154 (3.39); 2,1457 (6.5); 2.137 (3.61); 2.0977 (0.33); 2.0934 (0.36); 1.8383 (0.5); 0.829 (0.31); 0.8169 (0.65); 0.8116 (0.63); 0.8077 (0.51); 0.7996 (1.22); 0.7914 (0.51); 0.7874 (0.68); 0.7824 (0.66);
0,7797 (0,74); 0,7677 (0,39); 0,7624 (0,3); 0,24 (1,08); 0,2293 (3,15); 0,225 (3,34); 0,2201 (1,38); 0,2148 (1,56); 0,2092 (3,43); 0,2046 (3,11); 0,1948 (1,39); 0,0259 (1,3); 0,0155 (3,48); 0,01 18 (3,58); 0,0037 (3,15); -0,0002 (3,75); -0,01 12 (0,94); -0,2360.7797 (0.74); 0.7677 (0.39); 0.7624 (0.3); 0.24 (1.08); 0.2293 (3.15); 0.225 (3.34); 0.2201 (1.38); 0.2148 (1.56); 0.2092 (3.43); 0.2046 (3.11); 0.1948 (1.39); 0.0259 (1.3); 0.0155 (3.48); 0.0118 (3.58); 0.0037 (3.15); -0,0002 (3.75); -0.01 12 (0.94); -0.236
(1 .47) ; (1 .47);
Verbindung Nr. 243, Lösungsmittel: [DMSO], 400 MHz Compound No. 243, solvent: [DMSO], 400 MHz
12,9731 (0,41 ); 8,251 (3,21 ); 3,6158 (0,41 ); 3,363 (3,77); 3,352 (3,83); 3,3357 (3,14); 3,3175 (2,36); 3,3008 (1 ,31 ); 2,5069 (38,1 ); 2,5032 (50); 2,4997 (38,49); 2,3839 (2,12); 2,3761 (3,99); 2,3675 (2,38); 2,33 (0,34); 1 ,6514 (0,38); 1 ,6345 (0,81 ); 1 ,6178 (1 ,07); 1 ,6012 (0,94); 1 ,5844 (0,53); 1 ,449 (0,99); 1 ,4313 (2,3); 1 ,413 (2,23); 1 ,3957 (0,82); 0,9105 (12,69); 0,8938 (12,64); 0,8734 (2,91 ); 0,0015 (7,1 ); 0,0004 (6,65); -0,0002 (7,27); 12.9731 (0.41); 8.251 (3.21); 3.6158 (0.41); 3,363 (3.77); 3.352 (3.83); 3,3357 (3,14); 3,3175 (2.36); 3,3008 (1, 31); 2.5069 (38.1); 2.5032 (50); 2.4997 (38.49); 2.3839 (2,12); 2.3761 (3.99); 2.3675 (2.38); 2.33 (0.34); 1, 6514 (0.38); 1, 6345 (0.81); 1, 6178 (1, 07); 1, 6012 (0.94); 1, 5844 (0.53); 1, 449 (0.99); 1, 4313 (2, 3); 1,413 (2,23); 1, 3957 (0.82); 0.9105 (12.69); 0.8938 (12.64); 0.8734 (2.91); 0.0015 (7.1); 0.0004 (6.65); -0,0002 (7,27);
Verbindung Nr. 245, Lösungsmittel: [DMSO], 400 MHz Compound No. 245, solvent: [DMSO], 400 MHz
12,9256 (0,6); 8,8875 (0,57); 8,264 (1 1 ,72); 8,1541 (0,47); 5,9471 (1 ,08); 5,9341 (2,44); 5,9213 (2,29); 5,9083 (2,75); 5,9041 (1 ,44); 5,8954 (1 ,33); 5,891 1 (2,96);  12.9256 (0.6); 8.8875 (0.57); 8,264 (1 1, 72); 8.1541 (0.47); 5,9471 (1, 08); 5.9341 (2.44); 5.9213 (2.29); 5,9083 (2.75); 5,9041 (1,44); 5,8954 (1, 33); 5,891 1 (2.96);
5,8782 (2,69); 5,8654 (2,97); 5,8525 (1 ,36); 5,756 (0,57); 5,2409 (1 ,47); 5,2366 (4,54); 5,2323 (4,79); 5,228 (1 ,64); 5,1979 (1 ,31 ); 5,1936 (4,05); 5,1893 (4,21 ); 5,185 (1 ,45); 5,1374 (1 ,63); 5,1334 (4,89); 5,1294 (4,71 ); 5,1255 (1 ,53); 5,1 1 16 (1 ,51 ); 5,1077 (4,56); 5,1037 (4,46); 5,0997 (1 ,45); 3,9716 (2,45); 3,9675 (4,5); 3,9632 (3,04); 3,9574 (4,93); 3,9537 (7,66); 3,9444 (3,2); 3,9401 (4,62); 3,9359 (2,41 ); 3,4657 (0,78); 3,3667 (3,05); 2,6735 (0,31 ); 2,527 (0,58); 2,5223 (0,79); 2,5136 (15,95); 2,5091 (35,67); 5.8782 (2.69); 5,8654 (2,97); 5.8525 (1, 36); 5,756 (0.57); 5,2409 (1,47); 5.2366 (4.54); 5,2323 (4,79); 5,228 (1, 64); 5, 1979 (1, 31); 5.1936 (4.05); 5,1893 (4,21); 5.185 (1, 45); 5,1374 (1, 63); 5,1334 (4,89); 5.1294 (4.71); 5,1255 (1, 53); 5.1 1 16 (1, 51); 5,1077 (4,56); 5,1037 (4,46); 5,0997 (1,45); 3.9716 (2.45); 3.9675 (4.5); 3.9632 (3.04); 3.9574 (4.93); 3.9537 (7.66); 3.9444 (3.2); 3.9401 (4.62); 3.9359 (2.41); 3.4657 (0.78); 3.3667 (3.05); 2.6735 (0.31); 2,527 (0.58); 2.5223 (0.79); 2,5136 (15.95); 2.5091 (35.67);
2,5045 (50); 2,4999 (35,19); 2,4953 (15,63); 2,3882 (7,8); 2,3796 (15,38); 2,37072,5045 (50); 2.4999 (35.19); 2.4953 (15.63); 2.3882 (7.8); 2,3796 (15,38); 2.3707
(8.48) ; 2,3314 (0,32); 2,0875 (0,99); 2,0757 (0,67); -0,0002 (1 ,47); (8.48); 2.3314 (0.32); 2.0875 (0.99); 2.0757 (0.67); -0.0002 (1, 47);
Verbindung Nr. 247, Lösungsmittel: [DMSO], 400 MHz Compound No. 247, solvent: [DMSO], 400 MHz
12,9086 (0,38); 8,8968 (0,51 ); 8,6098 (1 ,87); 8,2584 (10,84); 4,8631 (5,16); 4,8612 (5,55); 4,8593 (4,93); 4,826 (4,36); 4,8223 (5,58); 4,8186 (4,21 ); 3,8865 (6,34); 3,872 (6,58); 3,6943 (4,81 ); 3,4504 (2,83); 3,148 (0,33); 2,673 (0,33); 2,5266 (0,67); 2,5218 (0,95); 2,5131 (15,95); 2,5086 (35,36); 2,5039 (50); 2,4993 (34,98); 2,4947 (15,22); 2,4474 (0,43); 2,4428 (0,45); 2,3885 (7,4); 2,38 (14,34); 2,3713 (7,54); 2,0749 (0,55); 1 ,7604 (0,6); 1 ,7256 (23,96); 1 ,7245 (24,57); 0,9096 (1 ,48); 0,8929 (1 ,41 ); -0,0002 (0,72); Verbindung Nr.248, Lösungsmittel: [DMSO], 400 MHz 12,9086 (0.38); 8.8968 (0.51); 8,6098 (1, 87); 8.2584 (10.84); 4,8631 (5,16); 4.8612 (5.55); 4,8593 (4.93); 4,826 (4,36); 4,8223 (5.58); 4,8186 (4,21); 3,8865 (6,34); 3,872 (6.58); 3,6943 (4,81); 3.4504 (2.83); 3.148 (0.33); 2,673 (0.33); 2.5266 (0.67); 2.5218 (0.95); 2.5131 (15.95); 2,5086 (35,36); 2.5039 (50); 2,4993 (34.98); 2,4947 (15,22); 2.4474 (0.43); 2.4428 (0.45); 2.3885 (7.4); 2.38 (14.34); 2.3713 (7.54); 2.0749 (0.55); 1, 7604 (0.6); 1, 7256 (23,96); 1, 7245 (24.57); 0.9096 (1, 48); 0.8929 (1, 41); -0,0002 (0.72); Compound No. 248, solvent: [DMSO], 400 MHz
8,3011 (1,32); 8,0237 (0,69); 7,6598 (0,51); 7,5785 (0,55); 7,5139 (0,43); 7,4915 (0,51); 7,3044 (0,62); 7,2819 (0,45); 7,2582 (2,44); 7,2385 (5,15); 7,2189 (3,28);  8.3011 (1.32); 8.0237 (0.69); 7.6598 (0.51); 7.5785 (0.55); 7.5139 (0.43); 7.4915 (0.51); 7.3044 (0.62); 7.2819 (0.45); 7.2582 (2.44); 7.2385 (5.15); 7.2189 (3.28);
7,1995 (0,63); 7,1765 (0,34); 7,0748 (5,12); 7,0693 (5,19); 7,0638 (4,5); 7,0446 (3,12); 7,0108 (0,32); 6,8625 (2,64); 6,8588 (2,62); 6,8442 (2,38); 6,8384 (2,41 ); 4,0574 (0,94); 4,0396 (2,89); 4,0218 (2,92); 4,004 (0,99); 3,8377 (0,32); 3,7943 (0,38); 3,745 (4,68); 3,7019 (5,62); 3,68 (0,44); 3,6358 (0,47); 3,4015 (0,64); 3,3576 (1,1); 3,3317 (6,83); 3,2886 (5,58); 3,1638 (0,54); 3,1196 (0,44); 2,6727 (0,31); 2,5082 (37,45); 2,5038 (50); 2,4993 (36,11 ); 2,3305 (0,33); 1 ,9873 (12,41 ); 1 ,9091 (6,68); 1 ,5881 (2,39); 1 ,569 (2,38); 1 ,5524 (28,49); 1 ,2371 (0,58); 1 ,1964 (3,35); 1 ,1786 (6,69); 7.1995 (0.63); 7.1765 (0.34); 7,0748 (5:12); 7,0693 (5:19); 7.0638 (4.5); 7.0446 (3.12); 7.0108 (0.32); 6.8625 (2.64); 6.8588 (2.62); 6.8442 (2.38); 6.8384 (2.41); 4.0574 (0.94); 4.0396 (2.89); 4.0218 (2.92); 4,004 (0.99); 3.8377 (0.32); 3.7943 (0.38); 3,745 (4.68); 3.7019 (5.62); 3.68 (0.44); 3.6658 (0.47); 3.4015 (0.64); 3.3576 (1.1); 3.3317 (6.83); 3,2886 (5.58); 3.1638 (0.54); 3.1996 (0.44); 2.6727 (0.31); 2.5082 (37.45); 2.5038 (50); 2.4993 (36.11); 2.3305 (0.33); 1, 9873 (12,41); 1, 9091 (6.68); 1, 5881 (2.39); 1, 569 (2.38); 1, 5524 (28.49); 1, 2371 (0.58); 1, 1964 (3,35); 1, 1786 (6.69);
1,1608 (3,29); 0,9141 (0,35); 0,9055 (0,43); 0,8887 (0,47); 0,8274 (0,39); 0,8214 (0,38); 0,8047 (0,35); -0,0002 (2,99); 1,1608 (3,29); 0.9141 (0.35); 0.9055 (0.43); 0.8888 (0.47); 0.8274 (0.39); 0.8214 (0.38); 0.8047 (0.35); -0,0002 (2.99);
Verbindung Nr.249, Lösungsmittel: [DMSO], 400 MHz Compound No. 249, solvent: [DMSO], 400 MHz
8,5933 (0,78); 8,2694 (3,47); 3,974 (0,31 ); 3,9574 (0,65); 3,9405 (0,73); 3,9206 (0,67); 3,9035 (0,32); 3,8559 (1,09); 3,6684 (1,68); 3,3741 (9,33); 2,5164 (15,24); 2,5119 (34,89); 2,5072 (50); 2,5026 (36,47); 2,498 (17,07); 2,3922 (2,29); 2,3837 (4,45); 8.5933 (0.78); 8,2694 (3,47); 3,974 (0.31); 3.9574 (0.65); 3.9405 (0.73); 3.9206 (0.67); 3.9035 (0.32); 3.8559 (1.09); 3.6684 (1.68); 3,3741 (9,33); 2,5164 (15,24); 2.5119 (34.89); 2,5072 (50); 2.506 (36.47); 2,498 (17.07); 2.3922 (2.29); 2.3837 (4.45);
2,3751 (2,49); 2,3342 (0,31); 2,0783 (0,71); 1,5997 (0,32); 1,5605 (0,51); 1,5418 (1,87); 1,5238 (2,57); 1,5062 (2,02); 1,488 (0,56); 1,4615 (0,42); 1,4427 (0,3); 1,1625 (8,17); 1,1459 (8,14); 0,9187 (1,43); 0,9041 (3,79); 0,9 (3,59); 0,8857 (7,88); 0,867 (3,28); 2.3751 (2.49); 2.3342 (0.31); 2.0783 (0.71); 1.5997 (0.32); 1.5605 (0.51); 1.5418 (1.87); 1.5238 (2.57); 1.5062 (2.02); 1.488 (0.56); 1.4615 (0.42); 1.4427 (0.3); 1,1625 (8,17); 1,1459 (8,14); 0.9187 (1.43); 0.9041 (3.79); 0.9 (3.59); 0.8857 (7.88); 0.867 (3.28);
Verbindung Nr.256, Lösungsmittel: [DMSO], 400 MHz Compound No. 256, solvent: [DMSO], 400 MHz
8,5969 (0,93); 8,2677 (3,34); 4,1141 (0,55); 4,0988 (0,43); 3,6729 (2,07); 3,3883 (8,21 ); 2,5569 (0,4); 2,5159 (17,58); 2,5114 (37,24); 2,5068 (50); 2,5022 (34,86);  8.5969 (0.93); 8.2677 (3.34); 4.1141 (0.55); 4.0988 (0.43); 3.6729 (2.07); 3,3883 (8,21); 2.5569 (0.4); 2.5159 (17.58); 2,5114 (37,24); 2,5068 (50); 2.5022 (34.86);
2,4977 (15,48); 2,4575 (0,35); 2,382 (4,22); 2,3734 (2,33); 2,3339 (0,31); 2,0779 2,4977 (15,48); 2.4575 (0.35); 2,382 (4,22); 2.374 (2.33); 2.3339 (0.31); 2.0779
(0,89); 1,6602 (0,49); 1,6434 (0,61); 1,6246 (0,66); 1,6077 (0,56); 1,5924 (0,34); (0.89); 1.6602 (0.49); 1.6434 (0.61); 1.6246 (0.66); 1.6077 (0.56); 1.5924 (0.34);
1,5205 (0,44); 1,5059 (0,37); 1,4985 (0,46); 1,4867 (0,73); 1,4721 (0,54); 1,4642 1.5205 (0.44); 1.5059 (0.37); 1.4985 (0.46); 1.4867 (0.73); 1.4721 (0.54); 1.4642
(0,61); 1,4496 (0,53); 1,4203 (0,38); 1,4053 (0,34); 1,3396 (0,31); 1,3179 (0,83); (0.61); 1.4496 (0.53); 1.4203 (0.38); 1.4053 (0.34); 1.3396 (0.31); 1.3179 (0.83);
1 ,3035 (0,93); 1 ,2965 (0,63); 1 ,2832 (1 ,02); 1 ,2693 (0,61 ); 1 ,2628 (0,47); 1 ,24871, 3035 (0.93); 1, 2965 (0.63); 1, 2832 (1, 02); 1, 2693 (0.61); 1, 2628 (0.47); 1, 2487
(0,43); 1,1723 (2,76); 1,1559 (8,97); 1,1395 (6,27); 0,9068 (3,09); 0,8928 (15,35);(0.43); 1.1723 (2.76); 1.1559 (8.97); 1,1395 (6,27); 0.9068 (3.09); 0.8928 (15.35);
0,8764 (14,08); 0,8711 (4,01); 0,8546 (2,95); Verbindung Nr. 258, Lösungsmittel: [DMSO], 400 MHz 0.8764 (14.08); 0.8711 (4.01); 0.8546 (2.95); Compound No. 258, solvent: [DMSO], 400 MHz
8,5998 (0,82); 8,2564 (3,86); 3,9055 (0,57); 3,8892 (0,82); 3,884 (0,66); 3,8676 (0,81 ); 3,8562 (1 ,41 ); 3,8519 (0,64); 3,6789 (1 ,82); 3,3864 (5); 2,53 (0,44); 2,5253 (0,61 ); 2,5165 (14,91 ); 2,512 (34,65); 2,5074 (50); 2,5027 (36,15); 2,4981 (16,68); 2,3897 (2,76); 2,3818 (4,99); 2,3733 (2,72); 2,3343 (0,3); 2,0784 (0,73); 1 ,7904 (0,61 ); 1 ,7737 (1 ); 1 ,7574 (1 ,03); 1 ,741 (0,66); 1 ,1623 (0,63); 1 ,1458 (0,68); 1 ,1 189 (8,63); 1 ,102 (8,58); 0,9268 (0,64); 0,9097 (9,6); 0,907 (9,63); 0,8996 (1 ,85); 0,8927 (8,98); 0,8901 (9,23); 0,8677 (0,33); Verbindung Nr. 266, Lösungsmittel: [DMSO], 400 MHz  8.5998 (0.82); 8.2564 (3.86); 3.9555 (0.57); 3.8892 (0.82); 3.884 (0.66); 3.8676 (0.81); 3,8562 (1, 41); 3.8519 (0.64); 3,6789 (1, 82); 3,3864 (5); 2.53 (0.44); 2.5253 (0.61); 2.5165 (14.91); 2,512 (34.65); 2,5074 (50); 2,5027 (36,15); 2.4981 (16.68); 2.3897 (2.76); 2.3818 (4.99); 2.373 (2.72); 2.3343 (0.3); 2.0784 (0.73); 1, 7904 (0.61); 1, 7737 (1); 1, 7574 (1, 03); 1, 741 (0.66); 1, 1623 (0.63); 1, 1458 (0.68); 1, 189 (8.63); 1, 102 (8, 58); 0.9268 (0.64); 0.9097 (9.6); 0.907 (9.63); 0.8996 (1, 85); 0.8927 (8.98); 0.8901 (9.23); 0.8677 (0.33); Compound No. 266, solvent: [DMSO], 400 MHz
8,2867 (3,35); 3,6241 (0,44); 3,5031 (0,46); 3,4919 (1 ,37); 3,4812 (2,22); 3,4713 (5,9); 3,4635 (2,84); 3,4516 (0,69); 3,3971 (0,48); 3,3409 (35,55); 3,274 (14,91 ); 3,2725 (14,52); 2,6705 (0,31 ); 2,5053 (37,53); 2,5019 (50); 2,498 (38,45); 2,3849 (2,23);  8,2867 (3,35); 3.6241 (0.44); 3.5031 (0.46); 3,4919 (1, 37); 3.4812 (2.22); 3.4713 (5.9); 3.4635 (2.84); 3.4516 (0.69); 3.3971 (0.48); 3,3409 (35,55); 3,274 (14.91); 3,2725 (14,52); 2.6705 (0.31); 2,5053 (37.53); 2.5019 (50); 2,498 (38.45); 2.3849 (2.23);
2,3772 (4,1 1 ); 2,3688 (2,32); 2,3286 (0,31 ); -0,0002 (3,49); -0,002 (3,24); 2.3772 (4.1 1); 2.3688 (2.32); 2.3286 (0.31); -0,0002 (3.49); -0.002 (3.24);
Verbindung Nr. 272, Lösungsmittel : [DMSO], 400 MHz Compound No. 272, solvent: [DMSO], 400 MHz
12,9871 (0,54); 8,2768 (3,79); 4,2082 (0,53); 4,1914 (0,66); 4,1719 (0,52); 3,4269 (1 ,05); 3,4129 (1 ,06); 3,4028 (2,03); 3,3888 (1 ,96); 3,3662 (0,39); 3,3573 (1 ,8); 3,3443 (2,01 ); 3,333 (1 ,65); 3,3148 (31 ,37); 3,2814 (25,74); 3,2647 (0,53); 3,2314 (0,36); 2,6708 (0,31 ); 2,5617 (0,35); 2,5573 (0,49); 2,5527 (0,45); 2,5243 (0,3); 2,5196 (0,47); 2,5109 (15,37); 2,5064 (35,17); 2,5017 (50); 2,4971 (35,56); 2,4926 (16,03); 2,4564 (0,47); 2,4518 (0,67); 2,4472 (0,51 ); 2,386 (2,27); 2,3777 (4,36); 2,3691 (2,43); 2,3287 (0,37); 2,0738 (0,73); 1 ,1664 (8,48); 1 ,1495 (8,47); -0,0002 (2,42); Verbindung Nr. 274, Lösungsmittel: [DMSO], 400 MHz  12.9871 (0.54); 8.2768 (3.79); 4,2082 (0.53); 4.1914 (0.66); 4.1719 (0.52); 3,4269 (1, 05); 3,4129 (1, 06); 3.4028 (2.03); 3,3888 (1, 96); 3.3662 (0.39); 3,3573 (1, 8); 3,3443 (2.01); 3,333 (1,65); 3,3148 (31, 37); 3,2814 (25,74); 3,2647 (0.53); 3.2314 (0.36); 2.6708 (0.31); 2.5617 (0.35); 2.5573 (0.49); 2.5527 (0.45); 2.5243 (0.3); 2.5196 (0.47); 2,5109 (15,37); 2.5064 (35.17); 2.5017 (50); 2,4971 (35,56); 2,4926 (16.03); 2.4564 (0.47); 2.4518 (0.67); 2.4472 (0.51); 2.386 (2.27); 2.3777 (4.36); 2.3691 (2.43); 2.3287 (0.37); 2.0738 (0.73); 1, 1664 (8.48); 1, 1495 (8.47); -0,0002 (2.42); Compound No. 274, solvent: [DMSO], 400 MHz
12,9397 (0,33); 8,2519 (2,85); 3,6289 (0,38); 3,4035 (2,13); 3,3879 (4,42); 3,3717 12.9397 (0.33); 8.2519 (2.85); 3.6289 (0.38); 3.4035 (2.13); 3,3879 (4,42); 3.3717
(4,63); 3,3455 (29,66); 3,2435 (9,67); 3,2412 (13,02); 2,6718 (0,31 ); 2,5027 (50); (4.63); 3,3455 (29,66); 3,2435 (9,67); 3,2412 (13.02); 2.6718 (0.31); 2.5027 (50);
2,4476 (0,48); 2,3783 (3,84); 2,3293 (0,34); 2,0864 (0,35); 2,075 (0,43); 1 ,7849 (0,39); 2.4476 (0.48); 2.3783 (3.84); 2.3293 (0.34); 2.0864 (0.35); 2.075 (0.43); 1, 7849 (0.39);
1 ,7692 (1 ,44); 1 ,7526 (2,12); 1 ,7368 (1 ,39); 1 ,7202 (0,36); 0,0023 (3,29); -0,0002 (4,22); 1, 7692 (1, 44); 1, 7526 (2,12); 1, 7368 (1, 39); 1, 7202 (0.36); 0.0023 (3.29); -0,0002 (4,22);
Verbindung Nr. 661 , Lösungsmittel: [DMSO], 400 MHz Compound No. 661, solvent: [DMSO], 400 MHz
13,0033 (0,79); 8,7891 (0,41 ); 8,303 (6,25); 3,3367 (5,33); 2,8494 (1 1 ,19); 2,8377 (1 1 ,05); 2,7178 (2,13); 2,6996 (2,15); 2,51 19 (21 ,59); 2,5075 (40,38); 2,503 (50); 2,4984 (34,59); 2,0866 (0,45); 2,0744 (0,4); 1,2029 (4,42); 1,1843 (9,35); 1,1657 (4,28); -0,0002 (6,37); 13,0033 (0.79); 8,7891 (0.41); 8,303 (6,25); 3.3367 (5.33); 2,8494 (1 1, 19); 2,8377 (1 1, 05); 2,7178 (2,13); 2,6996 (2.15); 2.51 19 (21, 59); 2.5075 (40.38); 2,503 (50); 2,4984 (34.59); 2.0866 (0.45); 2.0744 (0.4); 1,2029 (4:42); 1.1843 (9.35); 1,1657 (4,28); -0,0002 (6,37);
Verbindung Nr.662, Lösungsmittel: [DMSO], 400 MHz Compound No.662, solvent: [DMSO], 400 MHz
13,0264 (0,52); 8,3123 (3,14); 3,3726 (0,83); 3,3551 (1,56); 3,337 (2,22); 3,316413.0264 (0.52); 8,3123 (3,14); 3.376 (0.83); 3.3551 (1.56); 3.377 (2.22); 3.3164
(26,5); 3,2666 (0,41); 2,7174 (1,06); 2,699 (1,07); 2,5568 (0,96); 2,5524 (0,99); 2,5058 (39,26); 2,5015 (50); 2,4972 (36,04); 2,4511 (0,64); 1,2046 (2,18); 1,1862 (4,6); 1,1673 (2,24); 1,1572 (3,17); 1,1392 (6,35); 1,1212 (2,98); -0,0002 (4,68); Verbindung Nr.663, Lösungsmittel: [DMSO], 400 MHz (26.5); 3.2666 (0.41); 2.7174 (1.06); 2,699 (1.07); 2.5568 (0.96); 2.5524 (0.99); 2,5058 (39,26); 2.5015 (50); 2.4972 (36.04); 2.4511 (0.64); 1,2046 (2:18); 1,1862 (4,6); 1.1673 (2.24); 1.1572 (3.17); 1.1392 (6.35); 1.1212 (2.98); -0,0002 (4,68); Compound No.663, solvent: [DMSO], 400 MHz
13,0064 (0,5); 8,3049 (3,28); 3,3181 (22,78); 3,285 (1,91); 3,2701 (1,84); 3,2525 (0,94); 2,7167 (1,03); 2,6988 (1,06); 2,5109 (20,03); 2,5065 (38,97); 2,5019 (50);  13,0064 (0.5); 8.3049 (3.28); 3,3181 (22,78); 3,285 (1.91); 3.2701 (1.84); 3.2525 (0.94); 2.7167 (1.03); 2,6988 (1.06); 2.5109 (20.03); 2.5065 (38.97); 2.5019 (50);
2,4973 (35,14); 2,4929 (16,17); 2,0736 (0,3); 1,5728 (0,96); 1,5544 (1,87); 1,5367 (1,9); 1,5185 (1,08); 1,2036 (2,25); 1,185 (4,8); 1,1665 (2,18); 0,9204 (3,45); 0,902 (7,2); 0,8834 (3,04); -0,0002 (5,97); 2,4973 (35,14); 2,4929 (16,17); 2.0736 (0.3); 1.5728 (0.96); 1.5544 (1.87); 1.5367 (1.9); 1.5185 (1.08); 1,2036 (2.25); 1.185 (4.8); 1.1665 (2.18); 0.9204 (3.45); 0.902 (7.2); 0.8834 (3.04); -0,0002 (5,97);
Verbindung Nr.664, Solvent: [DMSO], 400 MHz  Compound No.664, solvent: [DMSO], 400 MHz
8,3088 (1,27); 4,1058 (0,32); 4,0891 (0,32); 3,3946 (50); 2,7128 (0,49); 2,6946 (0,49); 2,5106 (9,3); 2,5063 (11,76); 2,5023 (8,46); 2,07 (0,35); 1,1962 (4,53); 1,1798 (4,69); 1,1664 (0,98);  8.3088 (1.27); 4,1058 (0.32); 4.0891 (0.32); 3, 3946 (50); 2.7128 (0.49); 2.6946 (0.49); 2,5106 (9.3); 2.5063 (11.76); 2.5023 (8.46); 2.07 (0.35); 1.1962 (4.53); 1.1798 (4.69); 1.1664 (0.98);
Verbindung Nr.665, Lösungsmittel: [DMSO], 400 MHz Compound No.665, solvent: [DMSO], 400 MHz
12,9601 (1,09); 8,8178 (0,69); 8,2676 (9,4); 3,3309 (8,3); 2,8946 (1,19); 2,8848 (1,59); 2,8764 (2,56); 2,8664 (2,56); 2,8581 (1,67); 2,8483 (1,22); 2,8384 (0,45); 2,7072 (3,31); 2,6884 (3,36); 2,5134 (20,06); 2,509 (39,01); 2,5044 (50); 2,4999 (35,2); 2,4955 (16,28); 2,0876 (0,4); 1,1999 (6,86); 1,1813 (14,69); 1,1626 (6,66); 0,7817 (1,5);  12.9601 (1.09); 8.8178 (0.69); 8.2676 (9.4); 3,3309 (8,3); 2.8946 (1.19); 2.8848 (1.59); 2.8764 (2.56); 2.8664 (2.56); 2,8581 (1.67); 2.8483 (1.22); 2.8384 (0.45); 2.7072 (3.31); 2,6884 (3.36); 2.5134 (20.06); 2,509 (39.01); 2,5044 (50); 2.4999 (35.2); 2.4955 (16.28); 2.0876 (0.4); 1.1999 (6.86); 1.1813 (14.69); 1.1626 (6.66); 0.7817 (1.5);
0,7691 (4,68); 0,7637 (5,92); 0,7512 (6,07); 0,7457 (4,52); 0,7339 (2,02); 0,7142 (0,56); 0,6901 (0,73); 0,6781 (0,63); 0,6093 (1,94); 0,5988 (5,49); 0,592 (5,31); 0,5829 (4,5); 0,5703 (1,39); -0,0002 (7,95); Verbindung Nr.666, Lösungsmittel: [DMSO], 400 MHz 0.7691 (4.68); 0.7637 (5.92); 0.7512 (6.07); 0.7457 (4.52); 0.7339 (2.02); 0.7142 (0.56); 0.6901 (0.73); 0.6781 (0.63); 0.6093 (1.94); 0.5988 (5.49); 0.592 (5.31); 0.5829 (4.5); 0.5703 (1.39); -0,0002 (7,95); Compound No.666, solvent: [DMSO], 400 MHz
13,0076 (0,57); 8,3039 (4,37); 3,321 (22,36); 3,2897 (1,51); 2,7162 (1,4); 2,6981 (1,42); 2,5115 (20,6); 2,5071 (39,52); 2,5025 (50); 2,498 (34,87); 2,4936 (15,98);  13,0076 (0.57); 8.3039 (4.37); 3,321 (22.36); 3,2897 (1.51); 2.7162 (1.4); 2.6981 (1.42); 2.5115 (20.6); 2.5071 (39.52); 2.5025 (50); 2,498 (34.87); 2.4936 (15.98);
2,0865 (0,44); 2,0741 (0,39); 1,5528 (0,47); 1,5347 (1,42); 1,5171 (2,17); 1,4987 (1,73); 1,4801 (0,68); 1,3823(0,39); 1,3641 (1,33); 1,3449(1,96); 1,3261 (1,88); 1,3084 (1,13); 1,2035 (3,02); 1,185 (6,4); 1,1662 (2,91); 0,9227 (4,56); 0,9043 (9,56); 0,886 (3,94); -0,0002 (5,02); 2.0865 (0.44); 2.0741 (0.39); 1.5528 (0.47); 1.5347 (1.42); 1.5171 (2.17); 1.4987 (1.73); 1.4801 (0.68); 1.3823 (0.39); 1.3641 (1.33); 1.3449 (1.96); 1.3261 (1.88); 1.3084 (1.13); 1.2035 (3.02); 1.185 (6.4); 1.1662 (2.91); 0.9227 (4.56); 0.9043 (9.56); 0.886 (3.94); -0.0002 (5.02);
Verbindung Nr.667, Lösungsmittel: [DMSO], 400 MHz Compound No.667, solvent: [DMSO], 400 MHz
12,9695 (1,15); 8,9642 (0,58); 8,2934 (9,63); 4,4423 (0,98); 4,4222 (1 ,94); 4,4025 (1,89); 4,3816 (1,02); 3,3303 (6,99); 2,7153 (3,04); 2,6967 (3,13); 2,5133 (19,76); 12.9695 (1.15); 8.9642 (0.58); 8,2934 (9,63); 4.4423 (0.98); 4,4222 (1, 94); 4.4025 (1.89); 4.3816 (1.02); 3,3303 (6.99); 2,7153 (3.04); 2.6967 (3.13); 2,5133 (19,76);
2,5088 (38,74); 2,5043 (50); 2,4997 (35,02); 2,4953 (15,86); 2,3311 (0,33); 2,2998 (0,78); 2,2733 (2,47); 2,2667 (2,42); 2,2618 (2,44); 2,2545 (2,6); 2,2436 (2,15); 2,2332 (1,26); 2,2253 (1,03); 2,0948 (0,69); 2,0876 (1,01); 2,0712 (2,23); 2,0464 (3,08); 2.5088 (38.74); 2,5043 (50); 2.4997 (35.02); 2.4953 (15.86); 2.3311 (0.33); 2.2998 (0.78); 2.2733 (2.47); 2.2667 (2.42); 2.2618 (2.44); 2.2545 (2.6); 2.2436 (2.15); 2.2332 (1.26); 2.2253 (1.03); 2.0948 (0.69); 2.0876 (1.01); 2.0712 (2.23); 2.0464 (3.08);
2,0237 (2,16); 2,0176 (2,14); 1,9948 (0,69); 1,7485(1,35); 1,7341 (2,21); 1,7247(2,6); 1,715 (3); 1,708 (3,45); 1,6904 (1,88); 1,6824 (1,67); 1,6637 (0,7); 1,207 (6,51); 1,1884 (13,95); 1,1697 (6,28); -0,0002 (8,28); 2.0237 (2.16); 2.0176 (2.14); 1.9948 (0.69); 1.7485 (1.35); 1.7341 (2.21); 1.7247 (2.6); 1,715 (3); 1,708 (3.45); 1.6904 (1.88); 1.6824 (1.67); 1.6637 (0.7); 1,207 (6:51); 1,1884 (13.95); 1.1697 (6.28); -0,0002 (8,28);
Verbindung Nr.685, Lösungsmittel: [DMSO], 400 MHz Compound No.685, solvent: [DMSO], 400 MHz
12,9591 (0,79); 8,9431 (0,41 ); 8,3183 (7,09); 5,9517 (0,61 ); 5,9387 (1 ,4); 5,9259 (1,22); 5,9129 (1,58); 5,9087 (0,84); 5,9 (0,97); 5,8956 (1,67); 5,8828 (1,39); 5,8699 (1,63); 5,857 (0,74); 5,2441 (2,72); 5,2398 (2,64); 5,201 (2,42); 5,1968 (2,34); 5,1388 (2,93); 5,1348 (2,68); 5,1131 (2,7); 5,109 (2,46); 3,9738 (2,59); 3,9604 (4,41); 3,9508 (2,21); 3,9465 (2,55); 3,3279 (13,67); 2,7205 (2,28); 2,7019 (2,34); 2,5127 (20,18); 2,5081 (39,26); 2,5035 (50); 2,499 (35,07); 2,4945 (15,82); 2,087 (0,43); 2,0749 (0,32); 1,2041 (4,97); 1,1855 (10,72); 1,1668 (4,82); -0,0002 (13,59); 12.9591 (0.79); 8.9431 (0.41); 8,3183 (7.09); 5.9517 (0.61); 5.9387 (1, 4); 5.9259 (1.22); 5.9129 (1.58); 5.9087 (0.84); 5.9 (0.97); 5.8956 (1.67); 5.8828 (1.39); 5.8699 (1.63); 5.857 (0.74); 5.2441 (2.72); 5.2398 (2.64); 5.201 (2.42); 5.1968 (2.34); 5.1388 (2.93); 5.1348 (2.68); 5,1131 (2,7); 5.109 (2.46); 3.9738 (2.59); 3.9604 (4.41); 3.9508 (2.21); 3.9465 (2.55); 3,3279 (13,67); 2,7205 (2.28); 2.7019 (2.34); 2,5127 (20,18); 2,5081 (39,26); 2,5035 (50); 2,499 (35.07); 2.4945 (15.82); 2,087 (0.43); 2.0749 (0.32); 1,2041 (4,97); 1.1855 (10.72); 1.1668 (4.82); -0,0002 (13.59);
Verbindung Nr.688, Lösungsmittel: [DMSO], 400 MHz Compound No.688, solvent: [DMSO], 400 MHz
12,8955 (0,36); 9,0916 (0,56); 8,305 (6,79); 4,1254 (4,3); 4,1192 (4,79); 4,1115 (4,95); 4,1054 (4,04); 3,7405 (0,45); 3,6084 (0,62); 3,326 (15,72); 3,1821 (3,21); 3,1758 (6,24); 3,1696 (2,75); 2,7197 (2,35); 2,7011 (2,38); 2,5126 (21,19); 2,5082 (40,02); 2,5037 (50); 2,4991 (35,01); 2,4948 (16,22); 2,3309 (0,3); 2,087 (1,32); 2,075 (0,49); 1,1993 (4,82); 1,1807 (10,26); 1,1622 (4,6); -0,0002 (7,4); Verbindung Nr.689, Lösungsmittel: [DMSO], 400 MHz  12.8955 (0.36); 9.0916 (0.56); 8,305 (6.79); 4,1254 (4,3); 4,1192 (4,79); 4,1115 (4,95); 4,1054 (4.04); 3.7405 (0.45); 3.6084 (0.62); 3,326 (15,72); 3,1821 (3,21); 3,1758 (6,24); 3.1696 (2.75); 2,7197 (2.35); 2.7011 (2.38); 2,5126 (21,19); 2.5082 (40.02); 2,5037 (50); 2.4991 (35.01); 2,4948 (16,22); 2.3309 (0.3); 2.087 (1.32); 2.075 (0.49); 1,1993 (4.82); 1,1807 (10,26); 1.1622 (4.6); -0,0002 (7,4); Compound No.689, solvent: [DMSO], 400 MHz
13,0222 (0,71); 8,3117 (6,54); 3,9765 (0,5); 3,9596 (1,16); 3,9427 (1,38); 3,9234 (1,1); 3,9071 (0,49); 3,3278 (16,62); 2,7169 (2,13); 2,6985 (2,17); 2,5081 (39,01); 2,5036 (50); 2,4991 (35,82); 2,0872 (0,46); 2,0753 (0,42); 1,5627 (0,79); 1,5444 (2,93); 1,5265 (4,32); 1,5087 (3,19); 1,4906 (0,91); 1,2064 (4,46); 1,1878 (9,51); 1,1659(13,17); 1,1493 (11,55); 0,9048 (5,73); 0,8863 (11,73); 0,8677 (5,04); -0,0002 (6,35); 13.0222 (0.71); 8,3117 (6,54); 3.9765 (0.5); 3.9596 (1.16); 3.9427 (1.38); 3.9234 (1.1); 3.9071 (0.49); 3,3278 (16.62); 2,7169 (2,13); 2.6985 (2.17); 2.5081 (39.01); 2,5036 (50); 2.4991 (35.82); 2.0872 (0.46); 2.0753 (0.42); 1.5627 (0.79); 1.5444 (2.93); 1.5265 (4.32); 1,5087 (3,19); 1.4906 (0.91); 1,2064 (4:46); 1.1878 (9.51); 1.1659 (13.17); 1,1493 (11.55); 0.9048 (5.73); 0.8863 (11.73); 0.8677 (5.04); -0,0002 (6,35);
Verbindung Nr.712, Lösungsmittel: [DMSO], 400 MHz Compound No. 712, solvent: [DMSO], 400 MHz
8,3262 (1 ,58); 4,1961 (0,38); 3,4336 (0,73); 3,3652 (50); 3,2838 (5,76); 2,7133 (0,69); 2,6961 (0,7); 2,5034 (21,58); 2,0704 (0,38); 1,1987(1,21); 1,1742 (3,04); 1,1576 (2,97); -0,0002 (0,36); 8,3262 (1,158); 4.1961 (0.38); 3.4336 (0.73); 3,3652 (50); 3.2838 (5.76); 2,7133 (0.69); 2.6961 (0.7); 2.5034 (21.58); 2.0704 (0.38); 1.1987 (1.21); 1.1742 (3.04); 1.1576 (2.97); -0.0002 (0.36);
Verbindung Nr.714, Lösungsmittel: [DMSO], 400 MHz Compound No. 714, solvent: [DMSO], 400 MHz
12,9731 (0,58); 8,3074 (4,05); 3,4084 (2,5); 3,3929 (6,15); 3,3774 (4,49); 3,360712.9731 (0.58); 8.3074 (4.05); 3.4084 (2.5); 3,3929 (6,15); 3,3774 (4,49); 3.3607
(2,71); 3,3434 (2,03); 3,3224 (20,38); 3,2444 (24,3); 3,2399 (3,8); 2,718 (1,24); 2,6996(2.71); 3.3434 (2.03); 3,3224 (20,38); 3,2444 (24.3); 3.2399 (3.8); 2,718 (1.24); 2.6996
(1.3) ; 2,5115 (20,18); 2,507 (39,1); 2,5024 (50); 2,4978 (34,84); 2,4934 (15,68); 2,074 (0,32); 1 ,7938 (0,56); 1 ,7781 (1 ,88); 1 ,7614 (2,83); 1 ,7454 (1 ,77); 1 ,7287 (0,52); (1.3); 2.5115 (20.18); 2,507 (39.1); 2.5024 (50); 2,4978 (34,84); 2,4934 (15,68); 2.074 (0.32); 1, 7938 (0.56); 1, 7781 (1, 88); 1, 7614 (2,83); 1, 7454 (1, 77); 1, 7287 (0.52);
1,2023 (2,77); 1,1836 (5,91); 1,1649 (2,67); -0,0002 (6,59); 1,2023 (2,77); 1.1836 (5.91); 1.1649 (2.67); -0,0002 (6.59);
Verbindung Nr.700, Lösungsmittel : [DMSO], 400 MHz Compound No. 700, solvent: [DMSO], 400 MHz
13,0035 (1,16); 8,3017 (4,29); 3,8286 (2,12); 3,3573 (18,18); 2,7196 (4,64); 2,5777 13,0035 (1.16); 8:30 (4,29); 3.8286 (2.12); 3:3573 (18:18); 2,7196 (4,64); 2.5777
(4.04) ; 2,508 (50); 1,5765 (4,17); 1,4738 (4,2); 1,2065 (7,34); 1,1891 (8,58); 0,8912 (15,33); 0,8737 (17,75); 0,8557 (8,83); -0,0002 (3,72); (4.04); 2,508 (50); 1.5765 (4.17); 1.4738 (4.2); 1,2065 (7,34); 1.1891 (8.58); 0.8912 (15.33); 0.8737 (17.75); 0.8557 (8.83); -0,0002 (3.72);
Verbindung Nr.697, Lösungsmittel: [DMSO], 400 MHz Compound No.697, solvent: [DMSO], 400 MHz
13,0051 (1,24); 8,3008 (3,99); 3,889 (2,2); 3,3374 (24,01); 2,7128 (4,65); 2,5075 (50); 1,7743 (2,07); 1,182 (8,92); 1,1206 (10,37); 1,1041 (7,4); 0,9071 (18,7); 0,8915 (12,96); -0,0002 (3,57);  13,0051 (1.24); 8,3008 (3.99); 3,889 (2,2); 3,3374 (24.01); 2,7128 (4.65); 2.5075 (50); 1.7743 (2.07); 1,182 (8.92); 1,1206 (10,37); 1,1041 (7,4); 0.9071 (18.7); 0.8915 (12.96); -0.0002 (3.57);
Verbindung Nr.696, Lösungsmittel: [DMSO], 400 MHz Compound No.696, solvent: [DMSO], 400 MHz
13,0419 (2,04); 8,5883 (1,28); 8,3079 (6,12); 4,1323 (2,81); 3,3359 (25,49); 2,7164 (6,74); 2,5091 (50); 1,6274 (2,85); 1,4976 (3,09); 1,2913 (3,82); 1,1882 (18,08); 1,161 (16,92); 1,1445 (11,47); 0,8934 (30,47); 0,8773 (21,45); -0,0002 (6,23);  13.0419 (2.04); 8,5883 (1.28); 8,3079 (6,12); 4,1323 (2,81); 3,3359 (25,49); 2,7164 (6,74); 2,5091 (50); 1.6274 (2.85); 1.4976 (3.09); 1.2913 (3.82); 1,1882 (18.08); 1,161 (16.92); 1,1445 (11,47); 0.8934 (30.47); 0.8773 (21.45); -0,0002 (6,23);
Verbindung Nr.265, Lösungsmittel: [DMSO], 400 MHz Compound No. 265, solvent: [DMSO], 400 MHz
13,0208 (0,34); 8,5755 (0,35); 8,3064 (5,08); 3,6445 (0,87); 3,5729 (0,35); 3,5594 (0,33); 3,5373 (2,23); 3,5226 (5,72); 3,5085 (3,62); 3,4086 (2,81); 3,3948 (5,59);  13.0208 (0.34); 8.5755 (0.35); 8,3064 (5,08); 3.6445 (0.87); 3.5729 (0.35); 3.5594 (0.33); 3.5373 (2.23); 3.5226 (5.72); 3.5085 (3.62); 3.4086 (2.81); 3.3948 (5.59);
3,3806 (5,65); 3,3658 (3,68); 2,5249 (0,4); 2,5202 (0,57); 2,5114 (14,84); 2,5069 (34,81); 2,5023 (50); 2,4976 (35,84); 2,493 (16,17); 2,3889 (3,01); 2,3807 (5,74); 3,3806 (5.65); 3,3658 (3.68); 2.5249 (0.4); 2.5202 (0.57); 2.5114 (14.84); 2.5069 (34.81); 2.5023 (50); 2,4976 (35,84); 2,493 (16,17); 2.3889 (3.01); 2.3807 (5.74);
2,3721 (3,22); 2,3291 (0,33); 2,0738 (0,38); -0,0002 (4,93); 2,3721 (3,22); 2.3291 (0.33); 2.0738 (0.38); -0.0002 (4.93);
Verbindung Nr.807, Lösungsmittel: [DMSO], 400 MHz Compound No.807, solvent: [DMSO], 400 MHz
13,0396 (0,37); 8,285 (4,75); 3,9244 (0,84); 3,9074 (1 ); 3,9014 (0,88); 3,8906 (0,47); 3,8842 (0,83); 3,3172 (4,64); 2,7516 (0,46); 2,7335 (1,34); 2,7149 (1,4); 2,6967 (0,54); 2,5134 (5,87); 2,5089 (13,58); 2,5042 (19,63); 2,4996 (14,07); 2,495 (6,37); 1,2024 (3,42); 1,1838 (7,61); 1,1651 (3,42); 1,0884 (9,3); 1,0714 (9,29); 0,9602 (0,56); 0,9093 (50); 0,8594 (0,57); -0,0002 (2,84); 13.0396 (0.37); 8.285 (4.75); 3.9244 (0.84); 3,9074 (1); 3.9014 (0.88); 3.8906 (0.47); 3.8842 (0.83); 3,3172 (4,64); 2.7516 (0.46); 2.7335 (1.34); 2.7149 (1.4); 2.6967 (0.54); 2,5134 (5.87); 2,5089 (13.58); 2.5042 (19.63); 2.4996 (14.07); 2,495 (6.37); 1,2024 (3.42); 1.1838 (7.61); 1.1651 (3.42); 1.0884 (9.3); 1.0714 (9.29); 0.9602 (0.56); 0.9093 (50); 0.8594 (0.57); -0,0002 (2,84);
Verbindung Nr.325, Lösungsmittel: [DMSO], 400 MHz Compound No. 325, solvent: [DMSO], 400 MHz
11,8151 (0,65); 7,7169 (1,31); 3,3315 (50); 2,9705 (5,95); 2,8053 (6,17); 2,5118 (3,81); 2,5073 (8,52); 2,5027 (12,06); 2,4981 (8,52); 2,4935 (3,75); 2,3595 (1,15); 2,3508 (2,23); 2,3419 (1,2); -0,0002 (0,38);  11.8151 (0.65); 7.7169 (1.31); 3,3315 (50); 2.9705 (5.95); 2,8053 (6,17); 2.5118 (3.81); 2.5073 (8.52); 2.5027 (12.06); 2.4981 (8.52); 2.4935 (3.75); 2.3595 (1.15); 2.3508 (2.23); 2,3419 (1,2); -0.0002 (0.38);
Verbindung Nr.328, Lösungsmittel: [DMSO], 400 MHz Compound No. 328, solvent: [DMSO], 400 MHz
11,7329 (1,26); 7,6992 (4,23); 3,4525 (1,05); 3,4349 (3,46); 3,4172 (3,54); 3,3995 (1,23); 3,3879 (0,58); 3,3368 (50); 3,2869 (0,64); 3,1247 (0,95); 3,107 (3,06); 3,0892 (3,13); 3,0716 (1,01); 2,5123 (7,61); 2,5078 (17,32); 2,5032 (24,58); 2,4986 (17,63); 2,494 (7,99); 2,3617 (3,55); 2,353 (7,09); 2,3439 (3,83); 2,3303 (0,31 ); 2,0743 (0,42); 1,1432 (3,77); 1,1256 (8,41); 1,1078 (3,76); 1,0931 (0,33); 1,0329 (3,54); 1,0153 (7,94); 0,9975 (3,46);  11.7329 (1.26); 7.6992 (4.23); 3.4525 (1.05); 3.4349 (3.46); 3.4172 (3.54); 3.3995 (1.23); 3.3879 (0.58); 3,3368 (50); 3,2869 (0.64); 3.1247 (0.95); 3.107 (3.06); 3.0892 (3.13); 3.0716 (1.01); 2.5123 (7.61); 2.5078 (17.32); 2.5032 (24.58); 2.4986 (17.63); 2,494 (7.99); 2.3617 (3.55); 2.353 (7.09); 2.3439 (3.83); 2.3303 (0.31); 2.0743 (0.42); 1.1432 (3.77); 1.1256 (8.41); 1,1078 (3.76); 1.0931 (0.33); 1.0329 (3.54); 1.0153 (7.94); 0.9975 (3.46);
Verbindung Nr.875, Lösungsmittel: [DMSO], 400 MHz Compound No. 875, solvent: [DMSO], 400 MHz
11 ,8949 (1 ,33); 7,7346 (4,5); 3,6678 (0,38); 3,6016 (0,56); 3,3792 (0,36); 3,3308 (50); 2,9721 (15,73); 2,8083 (16,27); 2,7422 (0,64); 2,7235 (1,93); 2,7049 (2); 2,6864 (0,73); 2,5209 (0,33); 2,5121 (7,02); 2,5076 (15,92); 2,503 (22,59); 2,4984 (16,08); 2,4939 (7,25); 1,76 (0,69); 1,3556 (2,02); 1,1907 (4,55); 1,1721 (9,98); 1,1534 (4,45); -0,0002 (1,15); 11, 8949 (1, 33); 7,7346 (4,5); 3.6678 (0.38); 3.6016 (0.56); 3,3792 (0.36); 3,3308 (50); 2.9721 (15.73); 2,8083 (16,27); 2.7422 (0.64); 2.7235 (1.93); 2,7049 (2); 2.6864 (0.73); 2.5209 (0.33); 2.5121 (7.02); 2.5076 (15.92); 2,503 (22.59); 2.4984 (16.08); 2,4939 (7.25); 1.76 (0.69); 1.3556 (2.02); 1.1907 (4.55); 1.1721 (9.98); 1.1534 (4.45); -0,0002 (1.15);
Verbindung Nr.883, Lösungsmittel: [DMSO], 400 MHz Compound No.883, solvent: [DMSO], 400 MHz
12,9766 (0,98); 8,2908 (5,01); 3,7814 (0,42); 3,3361 (4,49); 3,2996 (1,43); 3,2826 (2,83); 3,2672 (2,82); 3,25 (1,42); 2,7306 (0,39); 2,7157 (0,7); 2,698 (1,26); 2,6778 (1,38); 2,526 (0,56); 2,5211 (0,88); 2,5124 (16,85); 2,508 (36,46); 2,5035 (50); 2,499 (36,38); 2,4946 (17,42); 2,4522 (0,38); 2,4478 (0,51); 2,3304 (0,3); 1,5859 (0,34); 12.9766 (0.98); 8,2908 (5.01); 3.7814 (0.42); 3.3361 (4.49); 3,2996 (1.43); 3.2826 (2.83); 3,2672 (2,82); 3.25 (1.42); 2.7306 (0.39); 2.7157 (0.7); 2,698 (1.26); 2.6778 (1.38); 2,526 (0.56); 2.5211 (0.88); 2.5124 (16.85); 2,508 (36.46); 2,5035 (50); 2,499 (36,38); 2,4946 (17.42); 2.4522 (0.38); 2,4478 (0.51); 2.3304 (0.3); 1.5859 (0.34);
1,5674 (1,54); 1,5492 (2,97); 1,5315(3,08); 1,5134(1,69); 1,4953 (0,4); 1,1918(3,06); 1,1733 (6,49); 1,1546 (2,96); 0,918 (5,34); 0,8995 (10,98); 0,8809 (4,73); 0,0079 (0,6); -0,0002 (19,78); -0,0085 (0,87); 1.5674 (1.54); 1.5492 (2.97); 1.5315 (3.08); 1.5134 (1.69); 1.4953 (0.4); 1.1918 (3.06); 1.1733 (6.49); 1.1546 (2.96); 0.918 (5.34); 0.8995 (10.98); 0.8809 (4.73); 0.0079 (0.6); -0.0002 (19.78); -0.0085 (0.87);
Verbindung Nr.885, Lösungsmittel: [DMSO], 400 MHz Compound No.885, solvent: [DMSO], 400 MHz
8,2255 (3,8); 3,7782 (0,41); 3,333 (22,2); 2,8834 (0,51); 2,8737 (0,7); 2,8652 (1,13); 2,8552 (1,14); 2,8467 (0,72); 2,837 (0,55); 2,6811 (1,45); 2,6627 (1,49); 2,5536 (0,44); 2,5477 (0,38); 2,5258 (0,77); 2,521 (1,07); 2,5123 (16,43); 2,5078 (36,11); 2,5032 (50); 2,4987 (36,29); 2,4942 (17,11); 1,1829 (3,09); 1,1644 (6,73); 1,1458 (2,99); 0,7734 (0,69); 0,7608 (1,97); 0,7555 (2,72); 0,743 (2,68); 0,7374 (2,08); 0,7257 (0,95); 0,7115 (0,32); 0,6868 (0,35); 0,6676 (0,44); 0,6643 (0,38); 0,5894 (0,82); 0,5786 (2,32);  8.2255 (3.8); 3.7782 (0.41); 3,333 (22.2); 2.8834 (0.51); 2.8737 (0.7); 2.8652 (1.13); 2,8552 (1.14); 2.8467 (0.72); 2,837 (0.55); 2.6811 (1.45); 2.6627 (1.49); 2.5536 (0.44); 2.5477 (0.38); 2.5258 (0.77); 2,521 (1.07); 2,5123 (16.43); 2.5078 (36.11); 2.5032 (50); 2,4987 (36.29); 2.4942 (17.11); 1.1829 (3.09); 1.1644 (6.73); 1.1458 (2.99); 0.7734 (0.69); 0.7608 (1.97); 0.7555 (2.72); 0.743 (2.68); 0.7374 (2.08); 0.7257 (0.95); 0.7115 (0.32); 0.6868 (0.35); 0.6676 (0.44); 0.6643 (0.38); 0.5894 (0.82); 0.5786 (2.32);
0,5724 (2,24); 0,5681 (2,07); 0,5628 (2,07); 0,5505 (0,66); 0,008 (0,34); -0,0002 (12,95); -0,0086 (0,56); 0.5724 (2.24); 0.5681 (2.07); 0.5628 (2.07); 0.5505 (0.66); 0.008 (0.34); -0,0002 (12,95); -0.0086 (0.56);
Verbindung Nr.908, Lösungsmittel: [DMSO], 400 MHz Compound No.908, solvent: [DMSO], 400 MHz
9,2675 (0,32); 8,2686 (6,28); 4,1214 (3,79); 4,1153 (4,25); 4,1077 (4,24); 4,1016 (3,8); 3,7801 (0,61); 3,7547 (0,46); 3,7484 (0,51); 3,6088 (0,32); 3,336 (10,88); 3,1789 (2,67); 3,1727 (5,58); 3,1665 (2,63); 2,6928 (2,26); 2,6738 (2,53); 2,5265 (0,9); 2,5129 (17,64); 2,5086 (36,99); 2,5041 (50); 2,4996 (36,17); 2,4952 (17,15); 2,331 (0,31); 1,1833 (5,04); 1,1648 (10,74); 1,1461 (4,76); 0,0077 (0,32); -0,0002 (9,55); -0,0084 (0,42);  9.2675 (0.32); 8,2686 (6,28); 4,1214 (3,79); 4,1153 (4,25); 4,1077 (4,24); 4,1016 (3,8); 3.7801 (0.61); 3.7547 (0.46); 3.7484 (0.51); 3.6088 (0.32); 3,336 (10.88); 3.1789 (2.67); 3,1727 (5,58); 3.1665 (2.63); 2.6928 (2.26); 2.6738 (2.53); 2.5265 (0.9); 2.5129 (17.64); 2.5086 (36.99); 2,5041 (50); 2.4996 (36.17); 2.4952 (17.15); 2.331 (0.31); 1.1833 (5.04); 1.1648 (10.74); 1.1461 (4.76); 0.0077 (0.32); -0,0002 (9.55); -0.0084 (0.42);
Verbindung Nr.926, Lösungsmittel: [DMSO], 400 MHz Compound No.926, solvent: [DMSO], 400 MHz
12,9978 (0,38); 8,3225 (7,85); 3,7821 (0,67); 3,5171 (0,48); 3,5077 (0,85); 3,4984 (3,01); 3,4871 (4,18); 3,4837 (3,95); 3,4762 (10,19); 3,4666 (5,99); 3,4544 (1,37); 12.9978 (0.38); 8,3225 (7,85); 3.7821 (0.67); 3.5171 (0.48); 3.5077 (0.85); 3.4984 (3.01); 3.4871 (4.18); 3.4837 (3.95); 3,4762 (10,19); 3.4666 (5.99); 3.4544 (1.37);
3,3412 (25,55); 3,3068 (1,18); 3,2769 (44,06); 3,1703 (0,43); 2,6993 (1,83); 2,682 (1,95); 2,5269 (0,67); 2,5222 (0,97); 2,5134 (16,63); 2,509 (36,22); 2,5045 (50); 2,4999 (36,32); 2,4954 (17,24); 2,3313 (0,31); 1,1878 (4,66); 1,1693 (9,99); 1,1507 (4,49); 1 ,0451 (0,32); -0,0002 (6,42); 3.3412 (25.55); 3.3068 (1.18); 3,2769 (44.06); 3.1703 (0.43); 2,6993 (1.83); 2,682 (1.95); 2.5269 (0.67); 2.5222 (0.97); 2.5134 (16.63); 2,509 (36,22); 2,5045 (50); 2.4999 (36.32); 2.4954 (17.24); 2.3313 (0.31); 1.1878 (4.66); 1.1693 (9.99); 1.1507 (4.49); 1, 0451 (0.32); -0,0002 (6,42);
Verbindung Nr.912, Lösungsmittel: [DMSO], 400 MHz Compound No. 912, solvent: [DMSO], 400 MHz
12,9886 (0,36); 8,2881 (7,65); 5,7588 (0,31); 4,0632 (0,48); 4,0447 (1,02); 4,0281 (1,42); 4,0116 (1,06); 3,9926 (0,5); 3,7831 (0,64); 3,7045 (0,31); 3,3558 (8,62); 3,1711 (0,4); 2,6978 (2,08); 2,6791 (2,27); 2,561 (0,46); 2,5566 (0,48); 2,5277 (0,64); 2,5141 (17,01); 2,5098 (36,54); 2,5053 (50); 2,5009 (36,26); 2,4966 (17,22); 2,4552 (0,42); 1,5437 (0,3); 1,5352 (0,35); 1,525 (0,86); 1,5106 (0,91); 1,5016 (1,31); 1,4961 (1,02); 1 ,487 (1 ,35); 1 ,4819 (1 ,76); 1 ,475 (1 ,25); 1 ,4675 (1 ,3); 1 ,4634 (1 ,52); 1 ,4595 (1 ,68); 1 ,4434 (1 ,32); 1 ,4259 (0,63); 1 ,4108 (0,52); 1 ,3924 (0,31 ); 1 ,3779 (0,54); 1 ,36 (1 ,24); 1,3456 (1,84); 1,3414 (1,71); 1,328 (2,17); 1,3232 (1,89); 1,3111 (1,48); 1,3055 (1,78); 1,2878 (1,05); 1,2722 (0,49); 1,2545 (0,31); 1,2342 (0,36); 1,1944 (4,85); 1,1759 (10,55); 1,1628 (14,54); 1,1579 (6,57); 1,1464 (13,25); 1,0462 (0,34); 0,9029 (7,31); 0,8846 (15,05); 0,8665 (6,21); 0,0079 (0,41); -0,0002 (13,75); 12.9886 (0.36); 8.2881 (7.65); 5.7588 (0.31); 4.0632 (0.48); 4.0447 (1.02); 4.0281 (1.42); 4.0116 (1.06); 3.9926 (0.5); 3.7831 (0.64); 3.7045 (0.31); 3,3558 (8,62); 3.1711 (0.4); 2.6978 (2.08); 2.6791 (2.27); 2,561 (0.46); 2.5566 (0.48); 2.5277 (0.64); 2.5141 (17.01); 2.5098 (36.54); 2,5053 (50); 2,5009 (36,26); 2.4966 (17.22); 2,4552 (0.42); 1.5437 (0.3); 1.5352 (0.35); 1.525 (0.86); 1.5106 (0.91); 1.5016 (1.31); 1.4961 (1.02); 1, 487 (1, 35); 1, 4819 (1, 76); 1, 475 (1, 25); 1, 4675 (1, 3); 1, 4634 (1, 52); 1, 4595 (1, 68); 1, 4434 (1, 32); 1, 4259 (0.63); 1, 4108 (0.52); 1, 3924 (0.31); 1, 3779 (0.54); 1, 36 (1, 24); 1.3456 (1.84); 1.3414 (1.71); 1,328 (2,17); 1.3232 (1.89); 1.3111 (1.48); 1.305 (1.78); 1.2878 (1.05); 1.2722 (0.49); 1.2545 (0.31); 1.2342 (0.36); 1.1944 (4.85); 1.1759 (10.55); 1.1628 (14.54); 1.1579 (6.57); 1,1464 (13,25); 1.0462 (0.34); 0.9029 (7.31); 0.8846 (15.05); 0.8665 (6.21); 0.0079 (0.41); -0.0002 (13.75);
Verbindung Nr.331, Lösungsmittel: [DMSO], 400 MHz Compound No. 331, solvent: [DMSO], 400 MHz
8,23 (3,8); 3,3432 (8,53); 3,1705 (0,49); 2,8409 (9,79); 2,829 (9,8); 2,6714 (0,3);  8.23 (3.8); 3.3432 (8.53); 3.170 (0.49); 2,8409 (9.79); 2,829 (9.8); 2.6714 (0.3);
2,5251 (0,63); 2,5204 (0,86); 2,5117 (15,63); 2,5071 (35,55); 2,5025 (50); 2,4978 (35,63); 2,4932 (15,96); 2,3841 (0,99); 2,3688 (4,93); 2,3599 (2,6); 2,3294 (0,34); 2,0861 (0,86); -0,0002 (10,56); -0,0086 (0,34); 2.5251 (0.63); 2.5204 (0.86); 2.5117 (15.63); 2.5071 (35.55); 2.5025 (50); 2.4978 (35.63); 2.4932 (15.96); 2.3841 (0.99); 2.3688 (4.93); 2.3599 (2.6); 2.3294 (0.34); 2.0861 (0.86); -0.0002 (10.56); -0.0086 (0.34);
Verbindung Nr.353, Lösungsmittel: [DMSO], 400 MHz Compound No. 353, solvent: [DMSO], 400 MHz
12,9211 (0,31); 8,225 (4,04); 3,3659 (0,35); 3,3508 (1,38); 3,3325 (2,94); 3,3167 (50); 3,3006 (2,35); 2,5246 (0,62); 2,5198 (0,83); 2,5112 (15,37); 2,5066 (34,52); 2,5021 (48,79); 2,4975 (34,88); 2,493 (16,13); 2,367 (4,1 ); 2,3587 (2,42); 2,3289 (0,34);  12.9211 (0.31); 8.225 (4.04); 3,3659 (0.35); 3,3508 (1.38); 3.3325 (2.94); 3,3167 (50); 3,3006 (2.35); 2.5246 (0.62); 2.5198 (0.83); 2.5112 (15.37); 2.5066 (34.52); 2.5021 (48.79); 2,4975 (34,88); 2,493 (16,13); 2,367 (4,1); 2,3587 (2.42); 2.3289 (0.34);
1,6499 (0,44); 1,6332 (0,91); 1,6165 (1,22); 1,5997 (1,06); 1,5831 (0,59); 1,4473 (1 ,39); 1 ,4297 (2,79); 1 ,4111 (2,8); 1 ,3938 (1,13); 0,9099 (21 ,69); 0,8934 (20,74); - 0,0002 (11,13); -0,0085 (0,35); Verbindung Nr.354, Lösungsmittel: [DMSO], 400 MHz 1.6499 (0.44); 1.6332 (0.91); 1.6165 (1.22); 1.5997 (1.06); 1.5831 (0.59); 1.4473 (1, 39); 1, 4297 (2.79); 1,4111 (2,8); 1, 3938 (1.13); 0.9099 (21, 69); 0.8934 (20.74); - 0.0002 (11.13); -0.0085 (0.35); Compound No. 354, solvent: [DMSO], 400 MHz
8,243 (3,1); 5,9459 (0,38); 5,9329 (0,86); 5,9201 (0,75); 5,9072 (0,94); 5,9028 (0,49); 8,243 (3,1); 5.9459 (0.38); 5.9329 (0.86); 5.9201 (0.75); 5,9072 (0.94); 5.9028 (0.49);
5,8942 (0,44); 5,8899 (1,02); 5,877 (0,88); 5,8641 (1,01); 5,8512 (0,43); 5,2362 (0,49);5.8942 (0.44); 5.8899 (1.02); 5.877 (0.88); 5.8641 (1.01); 5.8512 (0.43); 5.2362 (0.49);
5,2318 (1,48); 5,2275 (1,53); 5,2231 (0,53); 5,1931 (0,42); 5,1887 (1,29); 5,18455.2318 (1.48); 5.2275 (1.53); 5.2231 (0.53); 5.1931 (0.42); 5.1887 (1.29); 5.1845
(1,36); 5,18 (0,48); 5,1344 (0,53); 5,1304 (1,63); 5,1263 (1,56); 5,1224 (0,5); 5,1086 (0,49); 5,1046 (1 ,52); 5,1006 (1 ,49); 5,0966 (0,48); 3,9698 (0,73); 3,9655 (1 ,32); (1.36); 5.18 (0.48); 5.1344 (0.53); 5.1304 (1.63); 5.1263 (1.56); 5.1224 (0.5); 5,1086 (0.49); 5,1046 (1, 52); 5,1006 (1, 49); 5.0966 (0.48); 3.9698 (0.73); 3,9655 (1, 32);
3,9612 (0,87); 3,9519 (2,11); 3,9423 (0,89); 3,9381 (1,33); 3,9339 (0,73); 3,3193 (50); 3.9612 (0.87); 3,9519 (2,11); 3.9423 (0.89); 3.9381 (1.33); 3.9339 (0.73); 3,3193 (50);
2,5248 (0,54); 2,52 (0,73); 2,5114 (14,1); 2,5068 (32,37); 2,5022 (45,89); 2,49752.5248 (0.54); 2.52 (0.73); 2.5114 (14.1); 2,5068 (32,37); 2.502 (45.89); 2.4975
(32,74); 2,4929 (14,7); 2,3788 (1,85); 2,3704 (3,46); 2,3617 (1,98); -0,0002 (7,45); Verbindung Nr.338, Lösungsmittel: [DMSO], 400 MHz (32.74); 2,4929 (14,7); 2.3788 (1.85); 2.3704 (3.46); 2.3617 (1.98); -0,0002 (7,45); Compound No. 388, solvent: [DMSO], 400 MHz
8,2123 (3,64); 3,3202 (20,81); 2,5249 (0,53); 2,5111 (13,12); 2,5069 (26,66); 2,5024 (35,37); 2,4978 (24,88); 2,4933 (11,13); 2,3525 (3,9); 2,3294 (0,41); 1,3744 (50);  8.2123 (3.64); 3,3202 (20,81); 2.5249 (0.53); 2.5111 (13.12); 2.5069 (26.66); 2.5024 (35.37); 2.4978 (24.88); 2,4933 (11,13); 2.3525 (3.9); 2.3294 (0.41); 1.3744 (50);
1,3563 (0,97); 1,3401 (0,31); 1,2565 (2,08); 1,2472 (1,66); 1,1882 (1,07); 0,008 (0,35); 0,0025 (2,48); -0,0002 (11 ,42); -0,0086 (0,38); 1.3563 (0.97); 1.3401 (0.31); 1.2565 (2.08); 1.2472 (1.66); 1.1882 (1.07); 0.008 (0.35); 0.0025 (2.48); -0,0002 (11, 42); -0.0086 (0.38);
Verbindung Nr.365, Lösungsmittel: [DMSO], 400 MHz Compound No. 365, solvent: [DMSO], 400 MHz
8,2314 (3,59); 4,12 (0,42); 4,1038 (0,59); 4,0884 (0,48); 3,37 (0,47); 3,3172 (42,77); 3,266 (0,45); 2,5245 (0,45); 2,5107 (16); 2,5064 (35,34); 2,5019 (50); 2,4973 (36,96); 2,4928 (17,97); 2,4465 (0,32); 2,3687 (3,83); 2,3289 (0,38); 1 ,6391 (0,47); 1 ,6187 (0,59); 1,6027 (0,58); 1,5865 (0,36); 1,5086 (0,45); 1,4942 (0,39); 1,4862 (0,49);  8.2314 (3.59); 4.12 (0.42); 4.1038 (0.59); 4.0884 (0.48); 3.37 (0.47); 3,3172 (42,77); 3,266 (0.45); 2.5245 (0.45); 2,5107 (16); 2.5064 (35.34); 2.5019 (50); 2,4973 (36,96); 2,4928 (17,97); 2.4465 (0.32); 2.3687 (3.83); 2.3289 (0.38); 1, 6391 (0.47); 1, 6187 (0.59); 1.6027 (0.58); 1.5865 (0.36); 1.5086 (0.45); 1.4942 (0.39); 1.4862 (0.49);
1,4744 (0,76); 1,46 (0,57); 1,4523 (0,63); 1,4378 (0,53); 1,3129 (0,66); 1,2991 (0,73); 1,292 (0,64); 1,2785 (1,05); 1,2651 (0,5); 1,2583 (0,48); 1,2441 (0,42); 1,1492 (6,71);1.4744 (0.76); 1.46 (0.57); 1.4523 (0.63); 1.4378 (0.53); 1.3129 (0.66); 1.2991 (0.73); 1,292 (0.64); 1.2785 (1.05); 1.2651 (0.5); 1.2583 (0.48); 1.2441 (0.42); 1.1492 (6.71);
I, 1329 (6,7); 0,8881 (14,62); 0,8716 (14,33); -0,0002 (4,23) I, 1329 (6,7); 0.8881 (14.62); 0.8716 (14.33); -0,0002 (4,23)
Verbindung Nr.2253, Lösungsmittel: [DMSO], 400 MHz Compound No. 2253, solvent: [DMSO], 400 MHz
II, 4283 (0,67); 8,0816 (3,1); 3,3318 (1,11); 2,6537 (1,19); 2,6358 (2,06); 2,6163 (1,31); 2,5054 (34,64); 2,501 (50); 2,4965 (37,14); 2,3408 (0,96); 2,0719 (1,61); 1,5837 (1 ,09); 1 ,5644 (1 ,96); 1 ,5455 (1 ,99); 1 ,5268 (1 ,19); 0,9647 (0,63); 0,9543 (1 ,3); 0,9468 (3,07); 0,9334 (5,88); 0,927 (3,18); 0,915 (9,55); 0,8964 (6,63); 0,8852 (3,05); 0,8775 (2,08); 0,8655 (0,74); -0,0002 (14,49);  II, 4283 (0.67); 8.0816 (3.1); 3.3318 (1.11); 2.6537 (1.19); 2,6358 (2.06); 2.6163 (1.31); 2,5054 (34,64); 2,501 (50); 2,4965 (37,14); 2.3408 (0.96); 2.0719 (1.61); 1,5837 (1, 09); 1, 5644 (1, 96); 1, 5455 (1, 99); 1, 5268 (1, 19); 0.9647 (0.63); 0.9543 (1, 3); 0.9468 (3.07); 0.9334 (5.88); 0.927 (3.18); 0.915 (9.55); 0.8964 (6.63); 0.8852 (3.05); 0.8775 (2.08); 0.8655 (0.74); -0,0002 (14,49);
Verbindung Nr.1095, Lösungsmittel: [DMSO], 400 MHz Compound No. 1095, solvent: [DMSO], 400 MHz
11,894 (0,52); 7,7305 (1,31); 3,3021 (20,16); 3,2789 (0,6); 2,9697 (5,86); 2,7998 (6); 2,6687 (0,32); 2,646 (0,47); 2,6263 (0,82); 2,6089 (0,51 ); 2,5547 (0,32); 2,5502 (0,41 ); 2,5219 (0,61); 2,508 (16,4); 2,5041 (35,23); 2,4998 (50); 2,4953 (36,77); 2,491 (17,71); 2,0848 (0,88); 1,5817 (0,46); 1,5629 (0,83); 1,5439 (0,83); 1,5252 (0,5); 0,9214 (1,97); 0,9032 (3,92); 0,8848 (1,72); 0,008 (0,56); -0,0002 (18,87); -0,0015 (15,77); -0,0086 (0,65);  11.894 (0.52); 7.7305 (1.31); 3,3021 (20,16); 3,2789 (0.6); 2.9697 (5.86); 2,7998 (6); 2.6687 (0.32); 2,646 (0.47); 2.6263 (0.82); 2.6089 (0.51); 2.5547 (0.32); 2,5502 (0.41); 2.5219 (0.61); 2,508 (16.4); 2,5041 (35,23); 2,4998 (50); 2,4953 (36.77); 2,491 (17.71); 2.0848 (0.88); 1.5817 (0.46); 1.5629 (0.83); 1.5439 (0.83); 1.5252 (0.5); 0.9214 (1.97); 0.9032 (3.92); 0.8848 (1.72); 0.008 (0.56); -0,0002 (18,87); -0.0015 (15.77); -0.0086 (0.65);
Verbindung Nr.1049, Lösungsmittel: [CDCI3], 400 MHz Compound No. 1049, solvent: [CDCl3], 400 MHz
8,4693 (3,46); 7,2594 (50); 5,298 (1,51); 4,7897 (10,69); 3,8092 (18,82); 3,7458 (0,59); 2,8934 (0,98); 2,8735 (1,47); 2,8538 (1,07); 1,8524 (0,71); 1,752 (0,9); 1,733 (1,49); 1 ,7134 (1 ,56); 1 ,6946 (1 ,04); 1 ,676 (0,36); 1 ,5739 (0,37); 1 ,4318 (1 ,43); 1 ,0623 (3,97); 1,0441 (8,13); 1,0257 (3,79); 0,008 (0,62); -0,0002 (27,42); -0,0085 (0,92); 8,4693 (3,46); 7,2594 (50); 5,298 (1.51); 4,7897 (10.69); 3,8092 (18,82); 3.7458 (0.59); 2.8934 (0.98); 2.8735 (1.47); 2.8538 (1.07); 1.8524 (0.71); 1,752 (0.9); 1,733 (1.49); 1, 7134 (1, 56); 1, 6946 (1, 04); 1, 676 (0.36); 1, 5739 (0.37); 1, 4318 (1, 43); 1, 0623 (3.97); 1.0441 (8.13); 1.0257 (3.79); 0.008 (0.62); -0.0002 (27.42); -0.0085 (0.92);
Verbindung Nr.1096, Lösungsmittel: [DMSO], 400 MHz Compound No. 1096, solvent: [DMSO], 400 MHz
11 ,8221 (0,58); 7,7137 (1 ,84); 3,4505 (0,51 ); 3,433 (1 ,63); 3,4155 (1 ,64); 3,397711, 8221 (0.58); 7,7137 (1, 84); 3.4505 (0.51); 3,433 (1, 63); 3.4155 (1, 64); 3.3977
(0,54); 3,3037 (13,35); 3,1137 (0,5); 3,0958 (1,47); 3,078 (1,51); 3,0609 (0,49); 2,6317 (1,09); 2,5002 (50); 2,4958 (37,61); 1,5795 (0,59); 1,5604 (1,05); 1,5418 (1,08); 1,5223 (0,64); 1,3554 (0,64); 1,1448 (1,73); 1,1273 (3,71); 1,1098 (1,74); 1,018 (1,65); 1,0005 (3,54); 0,9829 (1,64); 0,9176 (2,33); 0,8995 (4,59); 0,881 (2,05); -0,0002 (17,38); (0.54); 3,3037 (13,35); 3,1137 (0.5); 3.0958 (1.47); 3,078 (1.51); 3.0609 (0.49); 2.6317 (1.09); 2,5002 (50); 2.4958 (37.61); 1.5795 (0.59); 1.5604 (1.05); 1.5418 (1.08); 1.5223 (0.64); 1.3574 (0.64); 1.1448 (1.73); 1.1273 (3.71); 1,1098 (1.74); 1.018 (1.65); 1,0005 (3.54); 0.9829 (1.64); 0.9176 (2.33); 0.8995 (4.59); 0.881 (2.05); -0.0002 (17.38);
Verbindung Nr.991, Lösungsmittel: [DMSO], 400 MHz Compound No.991, solvent: [DMSO], 400 MHz
13,0543 (0,43); 8,2854 (3,8); 3,3201 (3,61); 2,8461 (8,19); 2,8343 (8,32); 2,6597 (0,9); 2,6405 (1,37); 2,5512 (0,7); 2,5103 (15,31); 2,5058 (34,75); 2,5012 (50); 2,4967 (36,48); 2,4921 (17,14); 2,4511 (0,6); 2,3832 (0,39); 2,368 (0,38); 1,5974 (0,77);  13.0543 (0.43); 8.2854 (3.8); 3,3201 (3.61); 2,8461 (8,19); 2,8343 (8,32); 2.6597 (0.9); 2.6405 (1.37); 2.5512 (0.7); 2,5103 (15.31); 2,5058 (34.75); 2.5012 (50); 2,4967 (36,48); 2,4921 (17,14); 2.4511 (0.6); 2.3832 (0.39); 2.368 (0.38); 1.5974 (0.77);
1 ,5781 (1 ,35); 1 ,5592 (1 ,44); 1 ,5405 (0,84); 0,939 (3,67); 0,9207 (7,56); 0,9023 (3,34); -0,0002 (9,28); 1, 5781 (1, 35); 1, 5592 (1, 44); 1, 5405 (0.84); 0.939 (3.67); 0.9207 (7.56); 0.9023 (3.34); -0,0002 (9,28);
Verbindung Nr.992, Lösungsmittel: [DMSO], 400 MHz Compound No. 992, solvent: [DMSO], 400 MHz
13,0808 (0,51); 8,2936 (4,46); 3,3715 (0,99); 3,3534 (2,98); 3,3391 (3,64); 3,3353 (4,12); 3,3211 (5,78); 2,661 (1,01); 2,6413 (1,62); 2,6228 (1,05); 2,5243 (0,6); 2,5109 (15,13); 2,5063 (34,7); 2,5017 (50); 2,4972 (36,67); 2,4926 (17,4); 1,599 (0,92); 1,5803 (1,64); 1,561 (1,69); 1,5423 (1,02); 1,1552 (5,5); 1,1372 (11,98); 1,1191 (5,4); 0,9421 (4,31); 0,9239 (8,96); 0,9055 (3,93); -0,0002 (12,13); Verbindung Nr.993, Lösungsmittel: [DMSO], 400 MHz  13.0808 (0.51); 8,2936 (4:46); 3.3715 (0.99); 3.3534 (2.98); 3,3391 (3.64); 3,3353 (4,12); 3.3211 (5.78); 2,661 (1.01); 2.6413 (1.62); 2.6228 (1.05); 2.5243 (0.6); 2,5109 (15,13); 2.5063 (34.7); 2.5017 (50); 2,4972 (36,67); 2,4926 (17.4); 1,599 (0.92); 1.5803 (1.64); 1.561 (1.69); 1.5423 (1.02); 1.1552 (5.5); 1,1372 (11,98); 1.1191 (5.4); 0.9421 (4.31); 0.9239 (8.96); 0.9055 (3.93); -0.0002 (12.13); Compound No. 993, solvent: [DMSO], 400 MHz
13,0638 (0,3); 8,2871 (1,95); 3,3087 (9,08); 3,2827 (1,55); 3,2675 (1,32); 3,2505 (0,67); 2,6403 (0,7); 2,5097 (14,94); 2,5051 (34,45); 2,5006 (50); 2,496 (36,74); 2,4914 (17,45); 1,5971 (0,42); 1,5774 (0,75); 1,5687(0,88); 1,5503(1,51); 1,5322(1,42); 1,5147 (0,75); 0,9415 (1,9); 0,9234 (4,09); 0,9175 (2,73); 0,9048 (2,09); 0,8991 (5,11); 0,8804 (2,14); -0,0002 (7,98);  13.0638 (0.3); 8,2871 (1.95); 3.3087 (9.08); 3.2827 (1.55); 3.2675 (1.32); 3.2505 (0.67); 2.6403 (0.7); 2.5097 (14.94); 2,5051 (34,45); 2,5006 (50); 2,496 (36,74); 2,4914 (17,45); 1.5971 (0.42); 1.5774 (0.75); 1.5687 (0.88); 1.5503 (1.51); 1.5322 (1.42); 1.5147 (0.75); 0.9415 (1.9); 0.9234 (4.09); 0.9175 (2.73); 0.9048 (2.09); 0.8991 (5.11); 0.8804 (2.14); -0,0002 (7,98);
Verbindung Nr.994, Lösungsmittel: [DMSO], 400 MHz Compound No.994, solvent: [DMSO], 400 MHz
13,0946 (0,42); 8,2966 (3,91); 4,1151 (0,55); 4,0985 (0,86); 4,0804 (0,9); 4,0638 (0,59); 3,3136 (6,17); 3,17 (0,32); 2,6702 (0,38); 2,656 (0,82); 2,6367 (1,36); 2,6186 (0,88); 2,5238 (0,56); 2,5192 (0,78); 2,5104 (14,98); 2,5058 (34,58); 2,5012 (50); 13.0946 (0.42); 8.2966 (3.91); 4.1151 (0.55); 4.0985 (0.86); 4.0804 (0.9); 4.0638 (0.59); 3,3136 (6,17); 3.17 (0.32); 2.6702 (0.38); 2,656 (0.82); 2.6367 (1.36); 2.6186 (0.88); 2.5238 (0.56); 2.5192 (0.78); 2.5104 (14.98); 2,5058 (34.58); 2.5012 (50);
2,4966 (36,75); 2,4921 (17,43); 1,5973 (0,79); 1,5784 (1,39); 1,5591 (1,43); 1,5404 (0,85); 1,1947 (18,13); 1,1782 (17,98); 0,9439 (3,7); 0,9257 (7,68); 0,9073 (3,34); 0,0078 (0,33); -0,0002 (13,26); -0,0084 (0,46); 2.4966 (36.75); 2.4921 (17.43); 1.5973 (0.79); 1.5784 (1.39); 1.5591 (1.43); 1.5404 (0.85); 1,1947 (18:13); 1,1782 (17,98); 0.9439 (3.7); 0.9257 (7.68); 0.9073 (3.34); 0.0078 (0.33); -0,0002 (13,26); -0.0084 (0.46);
Verbindung Nr.995, Lösungsmittel: [DMSO], 400 MHz Compound No.995, solvent: [DMSO], 400 MHz
13,0165 (0,51); 8,2464 (3,96); 3,3195 (2,88); 2,889 (0,54); 2,8797 (0,8); 2,871 (1,18); 2,8611 (1,27); 2,8518 (0,77); 2,8427 (0,63); 2,648 (1); 2,6297 (1,61); 2,6116 (1,05); 2,5104 (15,25); 2,5059 (34,71); 2,5014 (50); 2,4969 (36,85); 2,4925 (17,69); 1,5926 (0,91 ); 1 ,5737 (1 ,59); 1 ,5543 (1 ,65); 1 ,5355 (1 ,01 ); 0,9393 (4,01 ); 0,9211 (8,22);  13.0165 (0.51); 8.2464 (3.96); 3,3195 (2,88); 2,889 (0.54); 2.8797 (0.8); 2,871 (1.18); 2.8611 (1.27); 2.8518 (0.77); 2.8427 (0.63); 2,648 (1); 2.6297 (1.61); 2.6116 (1.05); 2,5104 (15,25); 2,5059 (34,71); 2.504 (50); 2,4969 (36,85); 2.4925 (17.69); 1.5926 (0.91); 1, 5737 (1, 59); 1, 5543 (1, 65); 1, 5355 (1, 01); 0.9393 (4.01); 0.9211 (8.22);
0,9026 (3,62); 0,7777 (0,68); 0,7648 (2,02); 0,7599 (2,77); 0,7473 (2,74); 0,7419 (2,08); 0,73 (0,95); 0,5978 (0,84); 0,5868 (2,43); 0,5804 (2,29); 0,5712 (2,1); 0,559 (0,63); -0,0002 (13,52); Verbindung Nr.996, Lösungsmittel: [DMSO], 400 MHz 0.9026 (3.62); 0.7777 (0.68); 0.7648 (2.02); 0.7599 (2.77); 0.7473 (2.74); 0.7419 (2.08); 0.73 (0.95); 0.5978 (0.84); 0.5868 (2.43); 0.5804 (2.29); 0.5712 (2.1); 0.559 (0.63); -0.0002 (13.52); Compound No.996, solvent: [DMSO], 400 MHz
13,0634 (0,69); 8,2845 (4,88); 3,3368 (2,15); 3,319 (7,02); 3,3055 (6,49); 3,2877 (2,14); 2,6589 (1,11); 2,6386 (1,81); 2,6206 (1,18); 2,523 (0,73); 2,5096 (16,94);  13.0634 (0.69); 8,2845 (4,88); 3.3368 (2.15); 3,319 (7.02); 3,3055 (6,49); 3,2877 (2,14); 2.6589 (1.11); 2.6386 (1.81); 2,6206 (1.18); 2,523 (0.73); 2.5096 (16.94);
2,5053 (35,88); 2,5011 (50); 2,4967 (37,03); 2,4923 (18,13); 2,3278 (0,3); 1,5963 (1,03); 1,5774 (1,82); 1,5582 (1,88); 1,5482 (0,97); 1,539 (1,22); 1,531 (1,93); 1,5128 (2,66); 1 ,4944 (1 ,99); 1 ,4758 (0,84); 1 ,3788 (0,45); 1 ,3603 (1 ,55); 1 ,3411 (2,41 ); 2,5053 (35,88); 2,5011 (50); 2.4967 (37.03); 2,4923 (18,13); 2.3278 (0.3); 1.5963 (1.03); 1.5774 (1.82); 1.5582 (1.88); 1.5482 (0.97); 1,539 (1.22); 1,531 (1.93); 1.5128 (2.66); 1, 4944 (1, 99); 1, 4758 (0.84); 1, 3788 (0.45); 1, 3603 (1, 55); 1, 3411 (2.41);
1,3223 (2,39); 1,3044 (1,37); 1,2866 (0,39); 0,9413 (4,46); 0,9223 (12,04); 0,9031 (13,23); 0,8843 (4,74); 0,0067 (0,4); -0,0002 (11,78); -0,0015 (11,52); -0,0085 (0,5); 1.3223 (2.39); 1.3044 (1.37); 1.2866 (0.39); 0.9413 (4.46); 0.9223 (12.04); 0.9031 (13.23); 0.8843 (4.74); 0.0067 (0.4); -0,0002 (11,78); -0.0015 (11.52); -0.0085 (0.5);
Verbindung Nr.997, Lösungsmittel: [DMSO], 400 MHz Compound No.997, solvent: [DMSO], 400 MHz
13,0434 (0,3); 8,2701 (2,22); 4,4164 (0,49); 4,3964 (0,5); 3,3117 (6,58); 2,6343 (0,77);13.0434 (0.3); 8.2701 (2.22); 4,4164 (0.49); 4.3964 (0.5); 3.3117 (6.58); 2.6343 (0.77);
2,5232 (0,47); 2,5094 (15,05); 2,505 (34,53); 2,5004 (50); 2,4958 (36,59); 2,49132.5232 (0.47); 2.5094 (15.05); 2,505 (34.53); 2,5004 (50); 2.4958 (36.59); 2.4913
(17,32); 2,2509 (0,58); 2,0558 (0,47); 2,0315 (0,64); 2,0016 (0,5); 1,7294 (0,52); (17,32); 2.2509 (0.58); 2.0558 (0.47); 2.0315 (0.64); 2.0016 (0.5); 1.7294 (0.52);
1,7193 (0,61); 1,7095 (0,68); 1,7031 (0,83); 1,6856 (0,45); 1,6772 (0,44); 1,597 (0,44); 1.7193 (0.61); 1.7095 (0.68); 1.7031 (0.83); 1.6856 (0.45); 1.6772 (0.44); 1,597 (0.44);
1,5779 (0,75); 1,5594 (0,79); 1,5396 (0,48); 0,9416 (2); 0,9234 (4,15); 0,905 (1,84); - 0,0002 (12,2); 1.5779 (0.75); 1.5594 (0.79); 1.5396 (0.48); 0.9416 (2); 0.9234 (4.15); 0.905 (1.84); - 0.0002 (12.2);
Verbindung Nr.1005, Lösungsmittel: [DMSO], 400 MHz Compound No.1005, solvent: [DMSO], 400 MHz
13,0546 (0,43); 8,2891 (3,92); 3,3169 (4,48); 3,1669 (4,89); 3,1514 (4,87); 2,6418 (1,47); 2,5109 (14,43); 2,5065 (32,75); 2,5019 (46,9); 2,4974 (34,24); 2,4929 (16,21); 1,5907 (0,85); 1,5721 (1,51); 1,5526 (1,57); 1,5341 (0,92); 0,9414 (3,91); 0,9231 (8,57); 0,913 (50); -0,0002 (8,26); 13.0546 (0.43); 8.2891 (3.92); 3,3169 (4,48); 3,1669 (4,89); 3,1514 (4,87); 2.6418 (1.47); 2,5109 (14.43); 2.5065 (32.75); 2.5019 (46.9); 2,4974 (34,24); 2,4929 (16,21); 1.5907 (0.85); 1.5721 (1.51); 1.5526 (1.57); 1.5341 (0.92); 0.9414 (3.91); 0.9231 (8.57); 0.913 (50); -0,0002 (8,26);
Verbindung Nr.1013, Lösungsmittel: [DMSO], 400 MHz Compound No.1013, solvent: [DMSO], 400 MHz
8,2814 (3,36); 3,3559 (1,35); 3,3218 (8,4); 3,3057 (2,45); 2,6696 (0,41); 2,6596 (0,73); 2,6381 (1,19); 2,619 (0,75); 2,5234 (0,57); 2,5186 (0,77); 2,5097 (15,65); 2,5052 (34,9); 2,5008 (50); 2,4963 (36,65); 2,4918 (17,44); 1,6505 (0,35); 1,6337 (0,74); 8,2814 (3,36); 3.3559 (1.35); 3.3218 (8.4); 3,3057 (2.45); 2.6696 (0.41); 2.6596 (0.73); 2.6381 (1.19); 2,619 (0.75); 2.5234 (0.57); 2.5186 (0.77); 2.5097 (15.65); 2,5052 (34,9); 2,5008 (50); 2,46963 (36,65); 2,4918 (17,44); 1.6505 (0.35); 1.6337 (0.74);
1,6169(1,09); 1,6 (1,15); 1,5771 (1,26); 1,5579(1,26); 1,5391 (0,75); 1,4543 (1,11); 1,4367 (2,19); 1,4179 (2,21); 1,4006 (0,92); 0,941 (3,19); 0,9228 (6,65); 0,9131 (16,57); 0,9044 (3,5); 0,8966 (15,84); 0,008 (0,33); -0,0002 (12,3); -0,0012 (10,71 ); - 0,0086 (0,41); 1.6169 (1.09); 1.6 (1.15); 1.5771 (1.26); 1.5579 (1.26); 1.5391 (0.75); 1.4543 (1.11); 1.4367 (2.19); 1.4179 (2.21); 1.4006 (0.92); 0.941 (3.19); 0.9228 (6.65); 0.9131 (16.57); 0.9044 (3.5); 0.8966 (15.84); 0.008 (0.33); -0.0002 (12.3); -0.0012 (10.71); - 0.0086 (0.41);
Verbindung Nr.1017, Lösungsmittel: [DMSO], 400 MHz Compound No.1017, solvent: [DMSO], 400 MHz
13,0219 (0,32); 8,2898 (2,47); 4,8574 (1,36); 4,8243 (1,36); 3,8927 (1,58); 3,8783 (1 ,62); 3,3167 (5,35); 3,1696 (0,44); 2,6646 (0,74); 2,6439 (0,96); 2,5505 (0,47);  13.0219 (0.32); 8,2898 (2.47); 4,8574 (1.36); 4,8243 (1.36); 3.8927 (1.58); 3,8783 (1, 62); 3,3167 (5.35); 3.1696 (0.44); 2.6646 (0.74); 2.6439 (0.96); 2,5505 (0.47);
2,5096 (15,22); 2,5052 (34,65); 2,5006 (50); 2,4961 (36,83); 2,4916 (17,58); 2,4506 (0,45); 1,7251 (6); 1,597 (0,57); 1,5775 (0,97); 1,5588 (1,02); 1,541 (0,59); 0,9421 (2,5); 0,9238 (5,07); 0,9054 (2,26); -0,0002 (12,99); Verbindung Nr.1018, Lösungsmittel: [DMSO], 400 MHz 2.5096 (15.22); 2,5052 (34,65); 2,5006 (50); 2,4961 (36,83); 2.4916 (17.58); 2.4506 (0.45); 1.7251 (6); 1,597 (0.57); 1.5775 (0.97); 1.5588 (1.02); 1,541 (0.59); 0.9421 (2.5); 0.9238 (5.07); 0.9054 (2.26); -0,0002 (12,99); Compound No.1018, solvent: [DMSO], 400 MHz
8,2858 (1,3); 4,1228 (0,88); 4,1165 (0,95); 4,109 (0,97); 4,1028 (0,93); 3,3138 (2,7); 3,1688 (0,65); 3,1626 (1,32); 3,1564 (0,61); 2,6646 (0,5); 2,6435 (0,53); 2,509 (14,98); 2,5046 (34,39); 2,5 (50); 2,4955 (37,05); 2,4909 (17,83); 1,5737 (0,52); 1,5547 (0,52); 0,9379 (1,26); 0,9197 (2,65); 0,9013 (1,18); -0,0002 (14,68);  8.2858 (1.3); 4.1228 (0.88); 4.1165 (0.95); 4.109 (0.97); 4,1028 (0.93); 3,3138 (2,7); 3.1688 (0.65); 3.1626 (1.32); 3.1564 (0.61); 2.6646 (0.5); 2.6435 (0.53); 2,509 (14.98); 2.5046 (34.39); 2.5 (50); 2.4955 (37.05); 2.4909 (17.83); 1.5737 (0.52); 1.5547 (0.52); 0.9379 (1.26); 0.9197 (2.65); 0.9013 (1.18); -0,0002 (14,68);
Verbindung Nr.1022, Lösungsmittel: [DMSO], 400 MHz Compound No. 1022, solvent: [DMSO], 400 MHz
13,081 (0,51); 8,293 (3,85); 4,0418 (0,58); 4,0255 (0,75); 4,0076 (0,57); 3,3349 (0,6); 2,6388 (1,32); 2,6198 (0,91); 2,5104 (15,3); 2,5059 (34,71); 2,5014 (50); 2,4969 (36,74); 2,4924 (17,54); 2,3283 (0,3); 1,5975 (0,78); 1,5783 (1,36); 1,5598 (1,5);  13.081 (0.51); 8,293 (3.85); 4.0418 (0.58); 4.0255 (0.75); 4.0076 (0.57); 3.3349 (0.6); 2.6388 (1.32); 2,6198 (0.91); 2,5104 (15.3); 2,5059 (34,71); 2.504 (50); 2,4969 (36,74); 2,4924 (17.54); 2.3283 (0.3); 1.5975 (0.78); 1.5783 (1.36); 1.5598 (1.5);
1 ,5407 (1 ,03); 1 ,526 (0,65); 1 ,5029 (0,78); 1 ,4825 (0,86); 1 ,4601 (0,92); 1 ,4441 (0,77); 1,4261 (0,38); 1,3557 (0,75); 1,338 (0,97); 1,3204(1,16); 1,3031 (1,07); 1,2853(0,57); 1,1633 (8,54); 1,1468 (8,49); 0,9452 (3,4); 0,927 (7,1); 0,9085 (3,36); 0,9021 (4,64); 0,8838 (8,83); 0,8656 (3,62); 0,008 (0,63); -0,0002 (24,62); -0,0086 (0,8); Verbindung Nr.1026, Lösungsmittel: [DMSO], 400 MHz 1, 5407 (1, 03); 1, 526 (0.65); 1, 5029 (0.78); 1, 4825 (0.86); 1,4601 (0.92); 1, 4441 (0.77); 1.4261 (0.38); 1.3577 (0.75); 1,338 (0.97); 1.3204 (1,16); 1.3031 (1.07); 1.2853 (0.57); 1.1633 (8.54); 1.1468 (8.49); 0.9452 (3.4); 0.927 (7.1); 0.9085 (3.36); 0.9021 (4.64); 0.8838 (8.83); 0.8656 (3.62); 0.008 (0.63); -0.0002 (24.62); -0.0086 (0.8); Compound No. 1026, solvent: [DMSO], 400 MHz
8,2867 (1,58); 5,7516 (1,13); 3,3207 (2,93); 2,6366 (0,57); 2,5184 (0,69); 2,5096 (15,09); 2,5051 (34,59); 2,5005 (50); 2,496 (36,45); 2,4914 (17,07); 1,5782 (0,59); 1,5585 (0,59); 1,5403 (0,37); 1,4753 (0,33); 1,4538 (0,33); 1,3113 (0,36); 1,291 (0,47); 1,156 (3,11); 1,1396 (3,1); 0,9451 (1,49); 0,927 (3,12); 0,9086 (1,39); 0,8907 (5,84); 0,8743 (5,81); -0,0002 (10,92); -0,0084 (0,44);  8.2867 (1.58); 5.7516 (1.13); 3.3207 (2.93); 2.6366 (0.57); 2.5184 (0.69); 2.5096 (15.09); 2,5051 (34.59); 2,5005 (50); 2,496 (36,45); 2,4914 (17.07); 1.5782 (0.59); 1.5585 (0.59); 1.5403 (0.37); 1.4753 (0.33); 1.4538 (0.33); 1.3113 (0.36); 1,291 (0.47); 1,156 (3,11); 1.1396 (3.1); 0.9451 (1.49); 0.927 (3.12); 0.9086 (1.39); 0.8907 (5.84); 0.8743 (5.81); -0.0002 (10.92); -0.0084 (0.44);
Verbindung Nr.1033, Lösungsmittel: [DMSO], 400 MHz Compound No.1033, solvent: [DMSO], 400 MHz
8,3138 (1,32); 4,5158 (0,42); 4,5026 (0,94); 4,4895 (0,42); 3,4595 (0,78); 3,4453 (1,4); 3,4314 (0,79); 3,3089 (26,55); 2,6646 (0,52); 2,5091 (15,51 ); 2,5046 (34,9); 2,5001 (50); 2,4955 (36,23); 2,491 (16,99); 1,571 (0,49); 1,5514 (0,5); 0,9375 (1,27); 0,9192 (2,59); 0,9009 (1,11); -0,0002 (9,45);  8.3138 (1.32); 4.5158 (0.42); 4.506 (0.94); 4.4895 (0.42); 3.4595 (0.78); 3.4453 (1.4); 3.4314 (0.79); 3,3089 (26,55); 2.6646 (0.52); 2.5091 (15.51); 2.5046 (34.9); 2,5001 (50); 2.4955 (36.23); 2,491 (16.99); 1,571 (0.49); 1.5514 (0.5); 0.9375 (1.27); 0.9192 (2.59); 0.9009 (1.11); -0,0002 (9.45);
Verbindung Nr.1035, Lösungsmittel: [DMSO], 400 MHz Compound No. 1035, solvent: [DMSO], 400 MHz
8,3345 (2,84); 5,7513 (0,59); 3,5417 (1 ,14); 3,5273 (2,85); 3,5131 (1 ,78); 3,4116 (1,07); 3,3977 (2,54); 3,3834 (2,33); 3,3692 (1,12); 3,3227 (1,77); 2,6652 (0,79); 8.3345 (2.84); 5.7513 (0.59); 3.5417 (1, 14); 3.5273 (2.85); 3.5131 (1.78); 3.4116 (1.07); 3.3977 (2.54); 3.3834 (2.33); 3.3692 (1.12); 3,3227 (1.77); 2.6652 (0.79);
2,6454 (1,01); 2,5097 (15,15); 2,5053 (34,66); 2,5007 (50); 2,4962 (36,95); 2,4917 (17,7); 1,5965 (0,59); 1,5782 (1,04); 1,5587 (1,08); 1,5395 (0,62); 0,9405 (2,7); 0,9223 (5,58); 0,9038 (2,44); -0,0002 (10,11); 2.6454 (1.01); 2.5097 (15.15); 2,5053 (34,66); 2,5007 (50); 2.4962 (36.95); 2.4917 (17.7); 1.5965 (0.59); 1.5782 (1.04); 1.5587 (1.08); 1.5395 (0.62); 0.9405 (2.7); 0.9223 (5.58); 0.9038 (2.44); -0.0002 (10.11);
Verbindung Nr.1042, Lösungsmittel: [DMSO], 400 MHz Compound No. 1042, solvent: [DMSO], 400 MHz
13,0901 (0,4); 8,3131 (4,57); 5,7519 (0,6); 4,2077 (0,6); 4,1898 (0,79); 4,172 (0,65); 3,4325 (1,23); 3,4189 (1,23); 3,4084 (2,26); 3,3948 (2,27); 3,3669 (2,69); 3,3541 (3,11); 3,3428 (2,64); 3,3301 (2,64); 3,2856 (24,01); 3,2717 (2,55); 3,2306 (0,42); 2,641 (1 ,71 ); 2,5524 (0,33); 2,5109 (15,31 ); 2,5064 (34,83); 2,5019 (50); 2,4974 (36,68); 2,493 (17,55); 2,3351 (0,31); 1,5932 (0,97); 1,5747 (1,7); 1,5551 (1,79);  13,0901 (0.4); 8,3131 (4,57); 5.7519 (0.6); 4,2077 (0.6); 4,1898 (0.79); 4.172 (0.65); 3.4325 (1.23); 3.4189 (1.23); 3.4084 (2.26); 3.3948 (2.27); 3.3669 (2.69); 3.3541 (3.11); 3.3428 (2.64); 3,3301 (2.64); 3,2856 (24.01); 3.2717 (2.55); 3.2306 (0.42); 2,641 (1, 71); 2.5524 (0.33); 2,5109 (15.31); 2.5064 (34.83); 2.5019 (50); 2.4974 (36.68); 2,493 (17.55); 2.3351 (0.31); 1.5932 (0.97); 1.5747 (1.7); 1.5551 (1.79);
1 ,5364 (1 ,06); 1 ,1736 (8,57); 1 ,1567 (8,5); 1,1019 (0,69); 1 ,0868 (0,65); 0,9417 (4,13); 0,9234 (8,46); 0,905 (3,72); -0,0002 (5,98); Verbindung Nr.1028, Lösungsmittel: [DMSO], 400 MHz 1, 5364 (1, 06); 1, 1736 (8, 57); 1, 1567 (8.5); 1,1019 (0.69); 1, 0868 (0.65); 0.9417 (4.13); 0.9234 (8.46); 0.905 (3.72); -0.0002 (5.98); Compound No. 1028, solvent: [DMSO], 400 MHz
8,2826 (1,85); 3,8881 (0,37); 3,8673 (0,39); 3,3044 (22,59); 2,6696 (0,35); 2,6596 (0,42); 2,6365 (0,66); 2,6184 (0,43); 2,5231 (0,56); 2,5185 (0,77); 2,5097 (15,29); 2,5052 (34,79); 2,5006 (50); 2,496 (36,36); 2,4915 (17,03); 1,7713 (0,48); 1,7555 (0,49); 1,7388 (0,32); 1,5917 (0,39); 1,5726 (0,69); 1,5535 (0,72); 1,5348 (0,43); 1,1156 (4,03); 1,0987 (4,02); 0,9427 (1,81); 0,9245 (3,82); 0,9058 (5,71); 0,9007 (4,45); 0,8887 (4,06); 0,8837 (4,12); 0,0081 (0,65); -0,0002 (25,56); -0,0085 (0,83); 8.2826 (1.85); 3.8881 (0.37); 3.8673 (0.39); 3,3044 (22,59); 2.6696 (0.35); 2.6596 (0.42); 2.6365 (0.66); 2.6184 (0.43); 2.5231 (0.56); 2.5185 (0.77); 2,5097 (15,29); 2,5052 (34.79); 2,5006 (50); 2,496 (36,36); 2,4915 (17.03); 1.7713 (0.48); 1.7555 (0.49); 1.7388 (0.32); 1.5917 (0.39); 1.5726 (0.69); 1.5535 (0.72); 1.5348 (0.43); 1.1156 (4.03); 1.0987 (4.02); 0.9427 (1.81); 0.9245 (3.82); 0.9058 (5.71); 0.9007 (4.45); 0.8888 (4.06); 0.8837 (4.12); 0.0081 (0.65); -0,0002 (25.56); -0.0085 (0.83);
Verbindung Nr.1030, Lösungsmittel: [DMSO], 400 MHz Compound No.1030, solvent: [DMSO], 400 MHz
8,2847 (2,19); 3,8261 (0,42); 3,8058 (0,44); 3,3235 (19,85); 2,6415 (0,8); 2,5103 (14,9); 2,5059 (34,34); 2,5013 (50); 2,4968 (37,48); 2,4924 (18,24); 1,5727 (1,2); 8.2847 (2.19); 3.8261 (0.42); 3.8058 (0.44); 3.3235 (19.85); 2.6415 (0.8); 2.5103 (14.9); 2,5059 (34,34); 2,5013 (50); 2.4968 (37.48); 2,4924 (18,24); 1.5727 (1.2);
1 ,5596 (1 ,49); 1 ,5408 (1 ,2); 1 ,5088 (0,41 ); 1 ,4905 (0,76); 1 ,4716 (1 ,08); 1 ,4522 (0,91 ); 1,4369 (0,68); 1,4176 (0,47); 0,9478 (1,99); 0,9296 (4,1); 0,9196 (0,89); 0,9113 (1,83); 0,9008 (1,48); 0,8869 (4,24); 0,8684 (8,9); 0,8498 (3,74); -0,0002 (15,55); 1, 5596 (1, 49); 1, 5408 (1, 2); 1, 5088 (0.41); 1,4905 (0.76); 1, 4716 (1, 08); 1, 4522 (0.91); 1.4369 (0.68); 1.4176 (0.47); 0.9478 (1.99); 0.9296 (4.1); 0.9196 (0.89); 0.9113 (1.83); 0.9008 (1.48); 0.8869 (4.24); 0.8684 (8.9); 0.8498 (3.74); -0,0002 (15.55);
Verbindung Nr.1027, Lösungsmittel: [DMSO], 400 MHz Compound No. 1027, solvent: [DMSO], 400 MHz
13,0701 (0,32); 8,2918 (4,85); 8,1664 (0,41); 7,7617 (0,5); 3,9238 (1,05); 3,9016 (1,25); 3,8837 (1,08); 3,4342 (0,37); 2,966 (0,46); 2,6381 (2,59); 2,5041 (39,74);  13.0701 (0.32); 8,2918 (4,85); 8.1664 (0.41); 7.7617 (0.5); 3.9238 (1.05); 3.9016 (1.25); 3.8837 (1.08); 3.4342 (0.37); 2,966 (0.46); 2.6381 (2.59); 2.5041 (39.74);
1,5873 (1,26); 1,5684 (2,29); 1,5499 (2,31); 1,5316 (1,37); 1,1349 (3,41); 1,1181 (3,51 ); 1 ,0901 (8,74); 1 ,0731 (8,77); 0,9413 (5,06); 0,9227 (30,86); 0,9091 (50); - 0,0002 (9,65); 1.5873 (1.26); 1.5684 (2.29); 1.5499 (2.31); 1.5316 (1.37); 1.1349 (3.41); 1.1181 (3.51); 1, 0901 (8.74); 1, 0731 (8,77); 0.9413 (5.06); 0.9227 (30.86); 0.9091 (50); - 0.0002 (9.65);
Verbindung Nr.1128, Lösungsmittel: [DMSO], 400 MHz Compound No. 1128, solvent: [DMSO], 400 MHz
12,904 (0,37); 9,0849 (0,41 ); 8,2887 (5,63); 4,1237 (3,29); 4,1174 (3,58); 4,1097 (3,53); 4,1035 (3,39); 3,6042 (0,44); 3,322 (21,37); 3,1755 (2,2); 3,1693 (5,58); 3,163 (2,17); 2,6545 (1,73); 2,5104 (16,03); 2,5059 (35,72); 2,5013 (50); 2,4967 (36,1);  12.904 (0.37); 9.0849 (0.41); 8.2887 (5.63); 4,1237 (3,29); 4,1174 (3,58); 4,1097 (3.53); 4,1035 (3,39); 3.6042 (0.44); 3,322 (21:37); 3.1755 (2.2); 3,1693 (5,58); 3,163 (2,17); 2.6545 (1.73); 2.5104 (16.03); 2,5059 (35.72); 2,5013 (50); 2.4967 (36.1);
2,4922 (16,93); 2,3282 (0,31); 1,6021 (1); 1,5833 (1,75); 1,564 (1,8); 1,5451 (1,09); 0,9491 (4,44); 0,9309 (9,34); 0,9125 (4,04); -0,0002 (6,87); Verbindung Nr.1140, Lösungsmittel: [DMSO], 400 MHz 2.4922 (16.93); 2.3282 (0.31); 1.6021 (1); 1.5833 (1.75); 1,564 (1.8); 1.5451 (1.09); 0.9491 (4.44); 0.9309 (9.34); 0.9125 (4.04); -0,0002 (6,87); Compound No.1140, solvent: [DMSO], 400 MHz
8,2881 (1,53); 3,3056 (50); 2,6695 (0,48); 2,5096 (12,05); 2,505 (26,93); 2,5004 8.2881 (1.53); 3,3056 (50); 2.6695 (0.48); 2.5096 (12.05); 2,505 (26.93); 2.5004
(38,05); 2,4958 (27,02); 2,4912 (12,4); 1,6079 (0,47); 1,5894 (0,72); 1,574 (0,79);(38,05); 2.4958 (27.02); 2,4912 (12.4); 1.6079 (0.47); 1.5894 (0.72); 1,574 (0.79);
1,5611 (0,61); 1,5554 (0,64); 1,5423 (0,5); 1,4928 (0,43); 1,4741 (0,6); 1,4541 (0,53);1.5611 (0.61); 1.5554 (0.64); 1.5423 (0.5); 1.4928 (0.43); 1.4741 (0.6); 1.4541 (0.53);
1,4385 (0,38); 0,9598 (1,23); 0,9416 (2,63); 0,9233 (1,16); 0,9001 (0,4); 0,8897 (2,68); 0,8712 (5,89); 0,8526 (2,4); -0,0002 (5,22); 1.4385 (0.38); 0.9598 (1.23); 0.9416 (2.63); 0.9233 (1.16); 0.9001 (0.4); 0.8897 (2.68); 0.8712 (5.89); 0.8526 (2.4); -0.0002 (5.22);
Verbindung Nr.1129, Lösungsmittel: [DMSO], 400 MHz Compound No. 1129, solvent: [DMSO], 400 MHz
13,0277 (0,39); 8,2973 (3,53); 3,9581 (0,59); 3,9406 (0,63); 3,9214 (0,58); 3,3097 (37,17); 3,1695 (0,58); 2,6694 (0,82); 2,6479 (0,98); 2,51 (15,76); 2,5054 (35,27); 2,5008 (50); 2,4962 (35,75); 2,4916 (16,49); 1,6072 (0,59); 1,5874 (1,03); 1,5686 (1,1); 1,5429 (1,75); 1,5251 (2,21); 1,5071 (1,73); 1,489(0,46); 1,164 (6,56); 1,1474 (6,55); 0,9576 (2,73); 0,9394 (5,75); 0,921 (2,47); 0,9023 (3,17); 0,8839 (6,76); 0,8652 (2,8); - 0,0002 (7,22); 13.0277 (0.39); 8,2973 (3.53); 3.9581 (0.59); 3.9406 (0.63); 3.9214 (0.58); 3,3097 (37,17); 3.1695 (0.58); 2.6694 (0.82); 2.6479 (0.98); 2.51 (15.76); 2,5054 (35,27); 2,5008 (50); 2.4962 (35.75); 2,4916 (16,49); 1.6072 (0.59); 1.5874 (1.03); 1.5686 (1.1); 1.5429 (1.75); 1.5251 (2.21); 1.5071 (1.73); 1.489 (0.46); 1,164 (6.56); 1.1474 (6.55); 0.9576 (2.73); 0.9394 (5.75); 0.921 (2.47); 0.9023 (3.17); 0.8839 (6.76); 0.8652 (2.8); - 0.0002 (7.22);
Verbindung Nr.1105, Lösungsmittel: [DMSO], 400 MHz Compound No. 1105, solvent: [DMSO], 400 MHz
12,9697 (0,48); 8,8126 (0,47); 8,2562 (7,03); 5,7507 (0,38); 3,3148 (50); 3,1703 (1,54); 2,893 (0,82); 2,8832 (1,1); 2,8748 (1,78); 2,8647 (1,85); 2,8564 (1,08); 2,8466 (0,87); 2,8366 (0,32); 2,6583 (1 ,32); 2,639 (2,12); 2,6196 (1 ,41 ); 2,5243 (0,48); 2,511 (15,45); 2,5064 (34,87); 2,5018 (49,64); 2,4972 (35,7); 2,4926 (16,64); 1 ,6196 (0,31 ); 1 ,6017 (1,23); 1,5825 (2,1); 1,5631 (2,16); 1,5443 (1,34); 1,5264 (0,37); 0,9499 (5,65); 0,9316 (11,94); 0,9132 (5,14); 0,7795 (1,06); 0,7672 (2,85); 0,7617 (4,06); 0,7493 (4); 0,7436 (3,03); 0,7318 (1,5); 0,7126 (0,61); 0,7063 (0,56); 0,6887 (1,11); 0,6847 (0,95); 0,6775 (0,92); 0,6738 (0,82); 0,6077 (1,33); 0,5969 (3,49); 0,5906 (3,26); 0,5864 (3,06);  12.9697 (0.48); 8.8126 (0.47); 8.2562 (7.03); 5,7507 (0.38); 3,3148 (50); 3,1703 (1.54); 2,893 (0.82); 2.8832 (1.1); 2.8748 (1.78); 2.8647 (1.85); 2.8564 (1.08); 2.8466 (0.87); 2.8366 (0.32); 2,6583 (1, 32); 2,639 (2,12); 2,6196 (1, 41); 2.5243 (0.48); 2,511 (15,45); 2.5064 (34.87); 2.5018 (49.64); 2.4972 (35.7); 2,4926 (16,64); 1, 6196 (0.31); 1, 6017 (1.23); 1.5825 (2.1); 1.5631 (2.16); 1.5443 (1.34); 1.5264 (0.37); 0.9499 (5.65); 0.9316 (11.94); 0.9132 (5.14); 0.7795 (1.06); 0.7672 (2.85); 0.7617 (4.06); 0.7493 (4); 0.7436 (3.03); 0.7318 (1.5); 0.7126 (0.61); 0.7063 (0.56); 0.6888 (1.11); 0.6847 (0.95); 0.6775 (0.92); 0.6738 (0.82); 0.6077 (1.33); 0.5969 (3.49); 0.5906 (3.26); 0.5864 (3.06);
0,5809 (3,06); 0,5686 (1 ); -0,0002 (6,94); 0.5809 (3.06); 0.5686 (1); -0,0002 (6,94);
Verbindung Nr.2245, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2245, solvent: [CDCl3], 400 MHz
9,2422 (0,61); 8,393 (6,07); 7,26 (50); 5,298 (0,46); 4,0312 (0,45); 3,7153 (0,39);  9.2422 (0.61); 8,393 (6.07); 7.26 (50); 5,298 (0.46); 4.0312 (0.45); 3.7153 (0.39);
2,9852 (0,85); 2,9759 (1,18); 2,9669 (1,95); 2,9572 (1,94); 2,9486 (1,27); 2,939 (0,93); 2,9291 (0,32); 2,3944 (9,85); 2,3832 (10,07); 2,004 (0,84); 1 ,5632 (0,36); 1 ,25622.9852 (0.85); 2.9759 (1.18); 2.9669 (1.95); 2.9572 (1.94); 2,9486 (1.27); 2,939 (0.93); 2.9291 (0.32); 2.3944 (9.85); 2.3832 (10.07); 2.004 (0.84); 1, 5632 (0.36); 1, 2562
(1,18); 0,8868 (1,16); 0,8692 (4,22); 0,8556 (4,25); 0,8513 (3,3); 0,8381 (1,51); 0,8165 (0,31); 0,6448 (1,34); 0,6317 (3,31); 0,6276 (3,38); 0,6218 (3,3); 0,618 (3,27); 0,6044 (1,16); -0,0002 (7,26); Verbindung Nr.2, Lösungsmittel: [DMSO], 400 MHz (1.18); 0.8868 (1.16); 0.8692 (4.22); 0.8556 (4.25); 0.8513 (3.3); 0.8381 (1.51); 0.8165 (0.31); 0.6448 (1.34); 0.6317 (3.31); 0.6276 (3.38); 0.6218 (3.3); 0.618 (3.27); 0.6044 (1.16); -0.0002 (7.26); Compound No. 2, solvent: [DMSO], 400 MHz
9,7378 (0,47); 8,1072 (3,3); 3,4458 (0,35); 3,391 (50); 3,332 (0,76); 3,3135 (1,43); 3,2992 (1,45); 3,2954 (1,51); 3,2812 (1,4); 3,2632 (0,44); 3,1763 (0,76); 2,5168 (9,37); 2,5124 (20,54); 2,5079 (29,03); 2,5033 (20,64); 2,4988 (9,29); 2,2478 (7,94); 2,054 (8,09); 1,127 (3,03); 1,109 (6,35); 1,0909 (2,93); 0,0064 (0,47);  9.7378 (0.47); 8,1072 (3,3); 3.4458 (0.35); 3,391 (50); 3,332 (0.76); 3.3135 (1.43); 3.2992 (1.45); 3,2954 (1.51); 3.2812 (1.4); 3.2632 (0.44); 3,1763 (0.76); 2,5168 (9,37); 2.5124 (20.54); 2.5079 (29.03); 2.5033 (20.64); 2,4988 (9,29); 2.2478 (7.94); 2,054 (8.09); 1,127 (3.03); 1,109 (6,35); 1.0909 (2.93); 0.0064 (0.47);
Verbindung Nr.3, Lösungsmittel: [DMSO], 400 MHz Compound No. 3, solvent: [DMSO], 400 MHz
12,3016 (0,49); 9,8105 (0,53); 9,7967 (0,96); 9,7832 (0,53); 8,1013 (5,7); 7,9524 (0,35); 3,4415 (50); 3,2631 (1,49); 3,246 (2,95); 3,2312 (2,94); 3,2139 (1,53); 3,17 (1,31); 2,9214 (0,34); 2,8915 (2,92); 2,7324 (2,57); 2,5245 (0,47); 2,5197 (0,64); 2,5112 (13,61); 2,5067 (30,05); 2,5021 (42,36); 2,4976 (30,25); 2,4932 (14,29); 2,244 (13,85); 2,0713 (0,52); 2,049 (14,16); 1,5419 (0,33); 1,5236 (1,58); 1,5056 (3,09); 12, 3016 (0.49); 9.8105 (0.53); 9.7967 (0.96); 9.7832 (0.53); 8,1013 (5,7); 7.9524 (0.35); 3,4415 (50); 3.2631 (1.49); 3,246 (2.95); 3,2312 (2,94); 3.2139 (1.53); 3.17 (1.31); 2.9214 (0.34); 2,8915 (2,92); 2,7324 (2.57); 2.5245 (0.47); 2.5197 (0.64); 2.5112 (13.61); 2.5067 (30.05); 2,5021 (42,36); 2,4976 (30,25); 2,4932 (14,29); 2,244 (13.85); 2.0713 (0.52); 2,049 (14,16); 1.5419 (0.33); 1.5236 (1.58); 1.5056 (3.09);
I, 4877 (3,23); 1,4697 (1,76); 1,4516 (0,4); 0,9058 (5,33); 0,8874 (11); 0,8689 (4,79); 0,8387 (0,45); 0,82 (0,89); 0,8015 (0,39); 0,0009 (1,2); -0,0002 (1,21);  I, 4877 (3:23); 1.4697 (1.76); 1.4516 (0.4); 0.9058 (5.33); 0.8874 (11); 0.8689 (4.79); 0.8387 (0.45); 0.82 (0.89); 0.8015 (0.39); 0.0009 (1.2); -0,0002 (1.21);
Verbindung Nr.5, Lösungsmittel: [DMSO], 400 MHz Compound No. 5, solvent: [DMSO], 400 MHz
12,3151 (0,47); 9,7875 (1,1); 9,7771 (1 ,11 ); 8,0972 (5,74); 3,4683 (50); 3,383 (0,51 ); 3,1699 (1,68); 2,8369 (0,56); 2,8269 (0,73); 2,8188 (1,21); 2,8085 (1,28); 2,8003 (0,71); 2,7903 (0,63); 2,5241 (0,46); 2,5195 (0,66); 2,5106 (13,6); 2,5062 (30,78);  12.3151 (0.47); 9.7875 (1.1); 9, 771 (1, 11); 8.0972 (5.74); 3,4683 (50); 3.383 (0.51); 3.1699 (1.68); 2,8369 (0.56); 2.8269 (0.73); 2.8188 (1.21); 2,8085 (1.28); 2,8003 (0.71); 2,7903 (0.63); 2.5241 (0.46); 2.5195 (0.66); 2.5106 (13.6); 2.5062 (30.78);
2,5016 (44,25); 2,497 (32,42); 2,4925 (15,59); 2,3945 (0,36); 2,2393 (14,08); 2,0713 (0,52); 2,0486 (14,43); 0,7415 (0,83); 0,7289 (2,31); 0,7241 (2,94); 0,7113 (2,94); 2.5016 (44.25); 2,497 (32.42); 2.4925 (15.59); 2.3945 (0.36); 2.2393 (14.08); 2.0713 (0.52); 2.0486 (14.43); 0.7415 (0.83); 0.7289 (2.31); 0.7241 (2.94); 0.7113 (2.94);
0,7064 (2,35); 0,6943 (1,08); 0,4885 (1,02); 0,477 (2,73); 0,4718 (2,51); 0,4667 (2,42); 0,4618 (2,56); 0,4495 (0,85); -0,0002 (3,82); Verbindung Nr.108, Lösungsmittel: [DMSO], 400 MHz 0.7064 (2.35); 0.6943 (1.08); 0.4888 (1.02); 0.477 (2.73); 0.4718 (2.51); 0.4667 (2.42); 0.4618 (2.56); 0.4495 (0.85); -0.0002 (3.82); Compound No.108, solvent: [DMSO], 400 MHz
II, 838 (1,63); 7,2251 (7,56); 3,3826 (0,98); 3,3651 (2,9); 3,3474 (3,28); 3,315 (23,35); 3,1755 (0,97); 3,1698 (0,9); 3,158 (2,76); 3,1403 (2,78); 3,1229 (0,97); 2,5105 (8,42); 2,5062 (17,58); 2,5017 (24,22); 2,4973 (17,97); 2,4931 (9,01); 2,3375 (0,39); 2,1487 (16,82); 2,1079 (0,4); 1,9641 (17,1); 1,9083 (50); 1,103 (3,13); 1,0855 (6,59); 1,0679 (3,2); 1 ,0337 (3,18); 1 ,0161 (6,56); 0,9985 (3,03); -0,0002 (4,64);  II, 838 (1.63); 7.2251 (7.56); 3.3826 (0.98); 3,3651 (2.9); 3,3474 (3,28); 3,315 (23,35); 3.1755 (0.97); 3.1698 (0.9); 3.158 (2.76); 3,1403 (2,78); 3,1229 (0.97); 2.5105 (8.42); 2.5062 (17.58); 2,5017 (24,22); 2,4973 (17,97); 2.4931 (9.01); 2.3375 (0.39); 2,1487 (16,82); 2,1079 (0.4); 1.9641 (17.1); 1,9083 (50); 1,103 (3,13); 1.0855 (6.59); 1.0679 (3.2); 1, 0337 (3,18); 1, 0161 (6,56); 0.9985 (3.03); -0,0002 (4,64);
Verbindung Nr.2246, Lösungsmittel: [CDCI3], 400 MHz Compound No. 2246, solvent: [CDCl3], 400 MHz
8,4115 (7,55); 7,2629 (44,63); 7,2618 (50); 5,2995 (1,39); 5,2985 (1,57); 4,2867 (1,21); 4,2709 (1 ,75); 4,2551 (1 ,29); 4,2497 (1 ,02); 4,0504 (1,11); 3,0949 (2,25); 2,3973 (12,81); 2,3861 (13,11); 1,9871 (1,39); 1,9717(1,41); 1,6883(1,34); 1,67(1,74);  8.4115 (7.55); 7.2629 (44.63); 7,2618 (50); 5.2995 (1.39); 5.2985 (1.57); 4.2867 (1.21); 4,2709 (1, 75); 4,2551 (1, 29); 4,2497 (1, 02); 4.0504 (1.11); 3.0949 (2.25); 2.3973 (12.81); 2.3861 (13.11); 1.9871 (1.39); 1.9717 (1.41); 1.6883 (1.34); 1.67 (1.74);
1,6535 (1,66); 1,6369 (1,14); 1,5277 (1,14); 1,5122 (1,08); 1,5061 (1,22); 1,4927 (2,21); 1,478 (1,51); 1,4722 (1,83); 1,4567 (1,47); 1,368 (2,02); 1,3531 (1,96); 1,3476 (1 ,9); 1 ,3335 (2,65); 1 ,319 (1 ,22); 1 ,3137 (1 ,27); 1 ,2988 (1 ,08); 1 ,2617 (2,25); 1 ,2453 (2,12); 1,2261 (14,13); 1,2098 (14,11); 1,1371 (2,26); 1,1311 (2,31); 1,1207 (2,66); 1,115 (2,23); 0,9532 (1,59); 0,9432 (19,63); 0,9314 (16,52); 0,927 (21,05); 0,9149 (18,01); 0,9056 (6,38); 0,8976 (4,18); 0,889 (4,6); 0,001 (18,35); 0 (20,43); Verbindung Nr.7, Lösungsmittel: [DMSO], 400 MHz 1.6535 (1.66); 1.6369 (1.14); 1.5277 (1.14); 1.5122 (1.08); 1.5061 (1.22); 1.4927 (2.21); 1,478 (1.51); 1.4722 (1.83); 1.4567 (1.47); 1,368 (2.02); 1.3531 (1.96); 1,3476 (1, 9); 1, 3335 (2.65); 1, 319 (1, 22); 1, 3137 (1, 27); 1, 2988 (1, 08); 1, 2617 (2.25); 1, 2453 (2,12); 1,2261 (14,13); 1,2098 (14,11); 1.1371 (2.26); 1.1311 (2.31); 1.1207 (2.66); 1,115 (2.23); 0.9532 (1.59); 0.9432 (19.63); 0.9314 (16.52); 0.927 (21.05); 0.9149 (18.01); 0.9056 (6.38); 0.8976 (4.18); 0.889 (4.6); 0.001 (18.35); 0 (20.43); Compound No. 7, solvent: [DMSO], 400 MHz
12,3177 (0,39); 9,9824 (1,56); 9,9628 (1,69); 8,077 (10,85); 4,4017 (0,96); 4,3817 (1,77); 4,3605 (1,84); 4,3411 (1,03); 4,044 (1,28); 4,0235 (3,26); 4,0021 (4,89); 3,9824 (3,64); 3,9609 (1,59); 3,7602 (1,92); 3,1704 (1,69); 2,5123 (14,7); 2,5077 (34,35); 2,5031 (50); 2,4985 (36,44); 2,4939 (17,36); 2,2927 (0,73); 2,2849 (0,96); 2,2742 (1,49); 2,2665 (2,33); 2,2454 (27,28); 2,2264 (1,52); 2,2191 (1,17); 2,1832 (0,4);  12.3177 (0.39); 9.9824 (1.56); 9.9628 (1.69); 8.077 (10.85); 4,4017 (0.96); 4.3817 (1.77); 4.3605 (1.84); 4.3411 (1.03); 4,044 (1.28); 4.0235 (3.26); 4,0021 (4,89); 3.9824 (3.64); 3.9609 (1.59); 3.7602 (1.92); 3,1704 (1.69); 2.5123 (14.7); 2,5077 (34,35); 2.5031 (50); 2.4985 (36.44); 2.4939 (17.36); 2.2927 (0.73); 2.2849 (0.96); 2.2742 (1.49); 2.2665 (2.33); 2,2454 (27,28); 2.2264 (1.52); 2.2191 (1.17); 2,1832 (0.4);
2,1416 (1,87); 2,1348 (2,61); 2,1283 (2,04); 2,1228 (4,3); 2,1158 (6,22); 2,1095 (4,19); 2,1069 (3,54); 2,1039 (3,48); 2,1014 (3,99); 2,0943 (7,14); 2,0881 (5,31); 2,0825 (2,89); 2,0752 (3,3); 2,0724 (2,29); 2,0692 (2,84); 2,0422 (25,74); 1,9543 (0,55); 2.1416 (1.87); 2.1348 (2.61); 2.1283 (2.04); 2,1228 (4,3); 2,1158 (6,22); 2,1095 (4:19); 2,1069 (3,54); 2,1039 (3,48); 2,1014 (3.99); 2,0943 (7,14); 2.0881 (5.31); 2.0825 (2.89); 2.0752 (3.3); 2.0724 (2.29); 2.0692 (2.84); 2.0422 (25.74); 1.9543 (0.55);
1 ,9306 (1 ,78); 1 ,9096 (21 ,9); 1 ,8986 (2,77); 1 ,8826 (2,26); 1 ,8761 (2,37); 1 ,86061, 9306 (1, 78); 1, 9096 (21, 9); 1, 8986 (2,77); 1, 8826 (2.26); 1, 8761 (2.37); 1, 8606
(0,68); 1,8552 (0,7); 1,7917 (1,02); 1,7839 (0,94); 1,7681 (3,71); 1,7644 (3,47); 1,7613 (3,23); 1,7576 (2,3); 1,7459 (4,58); 1,7421 (5,85); 1,7355 (5,71); 1,7198 (5,54); 1,7129 (5,63); 1,7014 (2,46); 1,6977 (2,69); 1,6898 (2,82); 1,6754 (2,82); 1,6665 (1,26); (0.68); 1.8552 (0.7); 1.7917 (1.02); 1.7839 (0.94); 1.7681 (3.71); 1.7644 (3.47); 1.7613 (3.23); 1.7576 (2.3); 1.7459 (4.58); 1.7421 (5.85); 1.7355 (5.71); 1.7198 (5.54); 1.7129 (5.63); 1.7014 (2.46); 1.6977 (2.69); 1.6898 (2.82); 1.6754 (2.82); 1.6665 (1.26);
1,6559 (1,28); 1,6498 (1,37); 1,6313 (0,68); 1,5888 (0,82); 1,5684 (2,18); 1,564 (2,86); 1 ,5616 (3,11 ); 1 ,5588 (3,29); 1 ,5471 (2,39); 1 ,5401 (6,51 ); 1 ,5344 (3,82); 1 ,5205 (2,53); 1 ,5137 (5,86); 1 ,5067 (2,06); 1 ,4937 (2,11 ); 1 ,4878 (3,66); 1 ,4689 (1 ,66); 1.6559 (1.28); 1.6498 (1.37); 1.6313 (0.68); 1.5888 (0.82); 1.5684 (2.18); 1,564 (2.86); 1, 5616 (3,11); 1, 5588 (3,29); 1, 5471 (2.39); 1, 5401 (6.51); 1, 5344 (3.82); 1, 5205 (2.53); 1, 5137 (5.86); 1, 5067 (2.06); 1, 4937 (2,11); 1, 4878 (3.66); 1, 4689 (1, 66);
1,4613 (0,89); 1,4421 (0,44); 1,3562 (2,41); -0,0002 (5,08); 1.4613 (0.89); 1.4421 (0.44); 1.3562 (2.41); -0.0002 (5.08);
Verbindung Nr.8, Lösungsmittel: [CDCI3], 400 MHz Compound No. 8, solvent: [CDCl3], 400 MHz
9,5162 (1,07); 8,3966 (4,67); 7,2654 (15,89); 3,4883 (22,76); 2,356 (13,32); 2,1341 (13,29); 2,1066 (19,4); 2,0052 (45,5); 1,9928 (0,84); 1,906 (0,31); 1,4488 (50); 1,3498 (0,33); 1,315 (1,88); -0,0002 (2,58); 9.5162 (1.07); 8.3966 (4.67); 7.2654 (15.89); 3,4883 (22.76); 2,356 (13,32); 2,1341 (13,29); 2,1066 (19.4); 2,0052 (45.5); 1.9928 (0.84); 1.906 (0.31); 1.4488 (50); 1.3498 (0.33); 1.315 (1.88); -0,0002 (2.58);
Verbindung Nr.4, Lösungsmittel: [DMSO], 400 MHz Compound No. 4, solvent: [DMSO], 400 MHz
9,6938 (0,55); 9,6746 (0,54); 8,0945 (3,72); 4,0361 (0,49); 4,0191 (0,7); 4,0009 (0,77);9.6938 (0.55); 9.6746 (0.54); 8.0945 (3.72); 4.0361 (0.49); 4.0191 (0.7); 4,0009 (0.77);
3,9842 (0,54); 3,6656 (0,78); 3,6494 (1,61); 3,6333 (2,11); 3,617 (1,74); 3,6006 (1);3.9842 (0.54); 3.6656 (0.78); 3.6494 (1.61); 3.6333 (2.11); 3,617 (1.74); 3,6006 (1);
3,4322 (4,21); 3,1693 (2,13); 2,5104 (15,13); 2,5058 (34,79); 2,5012 (50); 2,49663.4322 (4.21); 3,1693 (2,13); 2,5104 (15,13); 2,5058 (34.79); 2.5012 (50); 2.4966
(36,18); 2,492 (16,82); 2,3283 (0,31); 2,2427 (8,61); 2,0712 (1,48); 2,0454 (8,82);(36,18); 2,492 (16.82); 2.3283 (0.31); 2.2427 (8.61); 2.0712 (1.48); 2.0454 (8.82);
1,9084 (16,91); 1,3556 (0,77); 1,1536 (13,42); 1,1372 (13,34); 1,0096 (29,31); 0,9933 (29,32); -0,0002 (4,88); 1,9084 (16.91); 1.3556 (0.77); 1.1536 (13.42); 1,1372 (13,34); 1,0096 (29.31); 0.9933 (29.32); -0,0002 (4,88);
Verbindung Nr.25, Lösungsmittel: [CDCI3], 400 MHz Compound No. 25, solvent: [CDCl3], 400 MHz
12,8088 (0,94); 9,744 (1,83); 8,4046 (8,45); 7,313 (0,4); 7,2674 (15,84); 7,2627 (50); 6,0119 (0,8); 5,9986 (1 ,71 ); 5,9857 (1 ,57); 5,9728 (2,16); 5,9691 (1,1); 5,9596 (1 ,59); 5,9556 (2,05); 5,9428 (1,79); 5,9298 (2,06); 5,9171 (1,66); 5,9039 (1,79); 5,8916 (1,42); 5,8783 (2,28); 5,8647 (1,68); 5,8611 (2,15); 5,8487 (1,61); 5,8354 (2,15); 12.8088 (0.94); 9.744 (1.83); 8,4046 (8,45); 7,313 (0.4); 7.2674 (15.84); 7,2627 (50); 6.0119 (0.8); 5,986 (1, 71); 5,9857 (1, 57); 5.9728 (2.16); 5.9691 (1.1); 5.9596 (1, 59); 5.9556 (2.05); 5.9428 (1.79); 5.9298 (2.06); 5.9171 (1.66); 5.9039 (1.79); 5.8916 (1.42); 5.8783 (2.28); 5.8647 (1.68); 5.8611 (2.15); 5.8487 (1.61); 5.8354 (2.15);
5,8219 (1,03); 5,3047 (2,17); 5,3006 (3,97); 5,2967 (3,52); 5,2617 (1 ,93); 5,2577 (3,55); 5,2538 (3,11); 5,2372 (4,19); 5,2334 (3,71); 5,1942 (3,71); 5,1905 (3,28); 5.8219 (1.03); 5,3047 (2,17); 5,3006 (3,97); 5.2967 (3.52); 5,2617 (1, 93); 5.2577 (3.55); 5.2538 (3.11); 5,2372 (4,19); 5.2334 (3.71); 5.1942 (3.71); 5,1905 (3,28);
5,1629 (4,23); 5,1592 (3,62); 5,1452 (4,94); 5,1415 (5,6); 5,1373 (4,91); 5,1335 (3,55); 5,1196 (4,2); 5,1161 (3,55); 4,1097 (3,82); 4,1 (5,82); 4,0962 (7,17); 4,0868 (3,37); 4,0828 (3,67); 3,8339 (6,52); 3,83 (8,73); 3,8259 (5,7); 3,8204 (6,9); 3,8164 (8,65); 3,8125 (4,51); 3,489 (0,37); 2,3609 (29,47); 2,3123 (0,36); 2,1994 (0,35); 2,1494 (25,76); 2,0046 (0,38); 1,4318 (1,44); 0,0045 (2,02); -0,0002 (7,16); 5,1629 (4,23); 5.1592 (3.62); 5,1452 (4,94); 5.1415 (5.6); 5.1373 (4.91); 5.1335 (3.55); 5,1196 (4,2); 5.1661 (3.55); 4,1097 (3.82); 4.1 (5.82); 4,0962 (7,17); 4.0868 (3.37); 4.0828 (3.67); 3.8389 (6.52); 3.83 (8.73); 3.8259 (5.7); 3.8204 (6.9); 3.8164 (8.65); 3.8125 (4.51); 3.489 (0.37); 2,3609 (29,47); 2.3123 (0.36); 2,1994 (0.35); 2,1494 (25,76); 2.0046 (0.38); 1.4318 (1.44); 0.0045 (2.02); -0,0002 (7,16);
Verbindung Nr.29, Lösungsmittel: [CDCI3], 400 MHz Compound No.29, solvent: [CDCl3], 400 MHz
13,0704 (0,74); 9,6106 (2,67); 9,5912 (2,74); 8,3941 (16,84); 7,2686 (26,66); 7,2661 13.0704 (0.74); 9,6106 (2.67); 9.5912 (2.74); 8.3941 (16.84); 7.2686 (26.66); 7.2661
(48,06); 4,3314 (0,45); 4,1493 (0,54); 4,1324 (1,55); 4,1159 (3,22); 4,0991 (3,94);(48.06); 4.3314 (0.45); 4.1493 (0.54); 4.1324 (1.55); 4,1159 (3:22); 4.0991 (3.94);
4,0804 (3,11); 4,0638 (1,57); 4,0472 (0,49); 3,7461 (0,52); 3,6971 (0,72); 3,6811 (3,29); 3,6648 (6,66); 3,6485 (6,8); 3,6323 (3,55); 3,6164 (0,84); 3,4883 (0,38); 2,37674.0804 (3.11); 4.0638 (1.57); 4.0472 (0.49); 3.7461 (0.52); 3.6971 (0.72); 3,6811 (3,29); 3.6648 (6.66); 3.6485 (6.8); 3,6323 (3.55); 3.6164 (0.84); 3.4883 (0.38); 2.3767
(47,61); 2,3062 (0,3); 2,1482 (48,49); 1,8535 (0,47); 1,6181 (1,72); 1,5992 (6,14);(47,61); 2.3062 (0.3); 2,1482 (48,49); 1.8535 (0.47); 1.6181 (1.72); 1.5992 (6.14);
1,5802 (9,03); 1,5644 (5,74); 1,5615 (6,09); 1,546 (2,23); 1,5336 (2,38); 1,5277 (2,12);1,5802 (9.03); 1.5644 (5.74); 1.5615 (6.09); 1.546 (2.23); 1.5336 (2.38); 1.5277 (2.12);
1,5149 (6,97); 1,5094 (6,45); 1,4974(10,15); 1,4925 (9,73); 1,4789 (8,1); 1,47481.5149 (6.97); 1.5094 (6.45); 1.4974 (10.15); 1.4925 (9.73); 1.4789 (8.1); 1.4748
(7,82); 1,46 (2,93); 1,4569 (2,9); 1,432 (1,73); 1,3182 (0,34); 1,2322 (30,89); 1,2157 (30,72); 1,1623 (50); 1,146 (49,35); 1,0991 (0,32); 1,0822 (0,33); 1,0028 (0,39); 0,9865(7.82); 1.46 (2.93); 1.4569 (2.9); 1,432 (1.73); 1.3182 (0.34); 1.2322 (30.89); 1.2157 (30.72); 1.1623 (50); 1,146 (49.35); 1.0991 (0.32); 1.0822 (0.33); 1.0028 (0.39); .9865
(15,29); 0,9679 (30,74); 0,9482 (22,43); 0,9457 (25,24); 0,9271 (44,18); 0,9084(15,29); 0.9679 (30.74); 0.9482 (22.43); 0.9457 (25.24); 0.9271 (44.18); 0.9084
(20,17); 0,0022 (4,39); -0,0002 (7,73); (20,17); 0.0022 (4.39); -0.0002 (7.73);
Verbindung Nr.32, Lösungsmittel: [CDCI3], 400 MHz Compound No. 32, solvent: [CDCl3], 400 MHz
13,039 (0,4); 9,5932 (1 ,96); 9,5739 (2,04); 8,3979 (12,41 ); 7,3178 (0,53); 7,267513.039 (0.4); 9, 5932 (1, 96); 9.5739 (2.04); 8,3979 (12,41); 7.3178 (0.53); 7.2675
(35,16); 7,2656 (50); 7,218 (0,53); 5,3012 (1,19); 5,2993 (1,64); 4,8022 (0,31); 4,1957 (0,89); 4,1791 (1,94); 4,1618 (2,45); 4,1441 (2,07); 4,1271 (1,03); 3,7559 (1,93); 3,74 (3,86); 3,7241 (4,09); 3,7079 (2,31); 3,6918 (0,64); 2,4303 (0,45); 2,379 (37,4); 2,3312 (0,39); 2,2014 (0,46); 2,15 (37,81); 2,1025 (0,4); 1,5577 (1,34); 1,5502 (1,59); 1,5418 (3,01 ); 1 ,5334 (4,69); 1 ,525 (3,12); 1 ,5165 (6,68); 1 ,4991 (5,31 ); 1 ,4851 (3,96); 1 ,4683 (4,02); 1,4547 (6,06); 1,4376 (8,32); 1,4212 (6,45); 1,4039 (4,97); 1,3978 (6,94); (35.16); 7,2656 (50); 7.218 (0.53); 5.3012 (1.19); 5.2993 (1.64); 4.8022 (0.31); 4.1957 (0.89); 4,1791 (1.94); 4,1618 (2.45); 4,1441 (2.07); 4.1271 (1.03); 3.7559 (1.93); 3.74 (3.86); 3.7241 (4.09); 3.7079 (2.31); 3.6918 (0.64); 2.4303 (0.45); 2.379 (37.4); 2.3312 (0.39); 2,2014 (0.46); 2.15 (37.81); 2,1025 (0.4); 1.5577 (1.34); 1.5502 (1.59); 1.5418 (3.01); 1, 5334 (4.69); 1, 525 (3.12); 1, 5165 (6,68); 1,4991 (5.31); 1, 4851 (3.96); 1, 4683 (4.02); 1.4547 (6.06); 1.4376 (8.32); 1.4212 (6.45); 1.4039 (4.97); 1.3978 (6.94);
1,3797 (7,28); 1,3715(3,7); 1,3641 (5,48); 1,3481 (3,91); 1,3315(2,33); 1,3151 (0,96); 1,2991 (0,4); 1,2877 (0,41); 1,2718 (0,35); 1,2364 (24,1); 1,22 (23,94); 1,1839 (35,23); 1 ,1677 (34,89); 1 ,1362 (0,63); 1 ,1199 (0,44); 0,986 (0,36); 0,9809 (0,35); 0,9682 (0,59); 0,9476 (12,58); 0,9352 (21,16); 0,9292 (26,46); 0,9171 (35,97); 0,8997 (13,41); 0,8695 (0,45); 0,0017 (6,65); -0,0002 (9,45); 1,3797 (7.28); 1.3715 (3.7); 1.3641 (5.48); 1.3481 (3.91); 1.3315 (2.33); 1.3151 (0.96); 1.2991 (0.4); 1.2877 (0.41); 1.2718 (0.35); 1.2364 (24.1); 1.22 (23.94); 1,1839 (35,23); 1, 1677 (34.89); 1, 1362 (0.63); 1, 1199 (0.44); 0.986 (0.36); 0.9809 (0.35); .9682 (0.59); 0.9476 (12.58); 0.9352 (21.16); 0.9292 (26.46); 0.9171 (35.97); 0.8997 (13.41); 0.8695 (0.45); 0.0017 (6.65); -0,0002 (9.45);
Verbindung Nr.34, Lösungsmittel: [CDCI3], 400 MHz Compound No.34, solvent: [CDCl3], 400 MHz
12,9296 (0,66); 9,5825 (1 ,45); 9,5624 (1 ,51 ); 8,3892 (9,88); 7,264 (50); 5,2986 (2,12); 4,1807 (0,69); 4,1644 (1,44); 4,1478 (1,61); 4,1446 (1,7); 4,128 (1,55); 4,1115 (0,78); 3,7287 (0,32); 3,7103 (1,34); 3,6946 (2,74); 3,6785 (2,93); 3,6621 (1,63); 3,6482 (0,47); 2,3636 (24,2); 2,1439 (25,17); 1,5616 (0,74); 1,5548 (0,83); 1,5451 (1,87); 1,5358 (2,03); 1,5285 (1,61); 1,5191 (3,35); 1,5034 (2,41); 1,4442 (1,07); 1,4318 (2,87); 1 ,4284 (2,57); 1 ,41 (4,61 ); 1 ,394 (5,81 ); 1 ,3847 (3,98); 1 ,3789 (3,93); 1 ,3574 (3); 1 ,3428 (3,98); 1 ,3257 (5,41 ); 1 ,3215 (5,08); 1 ,3079 (10,88); 1 ,29 (13,4); 1 ,284 (15,4); 1,2308 (18,18); 1,2144 (17,72); 1,1955 (0,65); 1,1802 (0,44); 1,1315 (29,71); 1,1153 (29,94); 0,8931 (9,68); 0,8784 (26,35); 0,8608 (12,49); -0,0002 (10,14); -0,0085 (0,49); 12.9296 (0.66); 9.5825 (1, 45); 9.5624 (1, 51); 8,3892 (9,88); 7.264 (50); 5,2986 (2,12); 4,1807 (0.69); 4,1644 (1.44); 4.1478 (1.61); 4,1446 (1.7); 4.128 (1.55); 4.1115 (0.78); 3.7287 (0.32); 3,7103 (1.34); 3.6946 (2.74); 3.6785 (2.93); 3.6621 (1.63); 3.6482 (0.47); 2.3636 (24.2); 2,1439 (25,17); 1.5616 (0.74); 1.5548 (0.83); 1.5451 (1.87); 1.5358 (2.03); 1.5285 (1.61); 1.5191 (3.35); 1.5034 (2.41); 1.4442 (1.07); 1.4318 (2.87); 1, 4284 (2.57); 1, 41 (4.61); 1, 394 (5.81); 1, 3847 (3.98); 1, 3789 (3.93); 1, 3574 (3); 1, 3428 (3.98); 1, 3257 (5.41); 1, 3215 (5.08); 1, 3079 (10.88); 1, 29 (13.4); 1, 284 (15,4); 1,2308 (18:18); 1.2144 (17.72); 1.1955 (0.65); 1.1802 (0.44); 1.1315 (29.71); 1,1153 (29.94); 0.8931 (9.68); 0.8784 (26.35); 0.8608 (12.49); -0.0002 (10.14); -0.0085 (0.49);
Verbindung Nr.13, Lösungsmittel: [CDCI3], 400 MHz Compound No.13, solvent: [CDCl3], 400 MHz
12,9993 (1,15); 9,5691 (3,43); 8,2084 (17,89); 7,0722 (39,47); 3,5957 (0,37); 3,2942 12.9993 (1.15); 9.5691 (3.43); 8,2084 (17,89); 7.0722 (39.47); 3.5957 (0.37); 3.2942
(0,5); 3,1555 (8,49); 3,139 (12,03); 3,125 (8,89); 2,8762 (22,79); 2,8587 (23,36); (0.5); 3,1555 (8,49); 3,139 (12.03); 3.125 (8.89); 2,8762 (22,79); 2,8587 (23,36);
2,2109 (49,29); 2,1169 (0,33); 1,9589 (50); 1,8121 (0,31); 1,7974 (0,3); 1,2376 (1,56); 0,9041 (1,05); 0,892 (2,21); 0,8863 (1,9); 0,8741 (3,33); 0,8622 (2,13); 0,8546 (2,48); 2.2109 (49.29); 2.1169 (0.33); 1,9589 (50); 1.8121 (0.31); 1.7974 (0.3); 1.2376 (1.56); 0.9041 (1.05); 0.892 (2.21); 0.8863 (1.9); 0.8741 (3.33); 0.8622 (2.13); 0.8546 (2.48);
0,8424 (1,3); 0,8209 (0,97); 0,8132 (1,36); 0,801 (2,77); 0,7957 (2,37); 0,7833 (4,13);0.8424 (1.3); 0.8209 (0.97); 0.8132 (1.36); 0,801 (2,77); 0.7957 (2.37); 0.7833 (4.13);
0,7713 (2,63); 0,7637 (3,18); 0,7515 (1,74); 0,7318 (0,73); 0,3572 (2,39); 0,34290.7713 (2.63); 0.7637 (3.18); 0.7515 (1.74); 0.7318 (0.73); 0.3572 (2.39); 0.3429
(10,78); 0,3372 (7,57); 0,3221 (23,01); 0,3104 (7,63); 0,3045 (11,5); 0,3019 (12,95);(10.78); 0.3372 (7.57); 0.3221 (23.01); 0.3104 (7.63); 0.3045 (11.5); 0.3019 (12.95);
0,2903 (4,13); 0,2733 (0,76); 0,2536 (0,42); 0,0991 (2,87); 0,0858 (12,53); 0,0735 (12,47); 0,0615 (2,79); 0,0256 (3,7); 0,0121 (15,64); -0,0002 (15,71 ); -0,0124 (3,25); -0.2903 (4.13); 0.2733 (0.76); 0.2536 (0.42); 0.0991 (2.87); 0.0858 (12.53); 0.0735 (12.47); 0.0615 (2.79); 0.0256 (3.7); 0.0121 (15.64); -0.0002 (15.71); -0.0124 (3.25); -
0,1942 (5,9); 0.1942 (5.9);
Verbindung Nr.15, Lösungsmittel: [CDCI3], 400 MHz Compound No.15, solvent: [CDCl3], 400 MHz
8,4189 (3,59); 7,2647 (13,05); 7,263 (14,52); 3,2913 (3,67); 3,2765 (3,64); 2,9856 (5,37); 2,3763 (9,39); 2,1485 (9,52); 0,9932 (33,21 ); 0,9922 (35,3); 0,9142 (45,96); 0,9128 (50); 0,0017 (1 ,85); 0 (2,21); Verbindung Nr. 21 , Lösungsmittel: [CDCI3], 400 MHz 8.4189 (3.59); 7.2647 (13.05); 7.263 (14.52); 3,2913 (3,67); 3,2765 (3,64); 2,9856 (5.37); 2.3763 (9.39); 2,1485 (9.52); 0.9932 (33.21); 0.9922 (35.3); 0.9142 (45.96); 0.9128 (50); 0.0017 (1, 85); 0 (2.21); Compound No. 21, solvent: [CDCl3], 400 MHz
9,7388 (1 ,04); 8,4032 (6,57); 7,2661 (20,9); 3,3173 (3,46); 3,3022 (5,47); 3,2865 (3,57); 3,042 (13,44); 3,0249 (13,87); 2,381 (18,56); 2,1507 (18,89); 1 ,9217 (0,72); 1 ,905 (1 ,47); 1 ,8883 (1 ,89); 1 ,8716 (1 ,56); 1 ,8551 (0,9); 1 ,8427 (1 ,31 ); 1 ,8259 (2,56); 1 ,8092 (3,25); 1 ,7924 (2,67); 1 ,7756 (1 ,37); 1 ,759 (0,41 ); 1 ,432 (1 ,01 ); 1 ,0013 (26,66); 0,9846 (25,77); 0,9447 (50); 0,928 (48,17); -0,0002 (4,49);  9,7388 (1, 04); 8,4032 (6,57); 7.2661 (20.9); 3,3173 (3.46); 3.3022 (5.47); 3.2865 (3.57); 3,042 (13.44); 3.0249 (13.87); 2,381 (18.56); 2,1507 (18,89); 1, 9217 (0.72); 1, 905 (1, 47); 1, 8883 (1, 89); 1, 8716 (1, 56); 1, 8551 (0.9); 1, 8427 (1, 31); 1, 8259 (2.56); 1, 8092 (3,25); 1, 7924 (2.67); 1, 7756 (1, 37); 1, 759 (0.41); 1, 432 (1, 01); 1, 0013 (26,66); 0.9846 (25.77); 0.9447 (50); 0.928 (48.17); -0,0002 (4,49);
Verbindung Nr. 23, Lösungsmittel: [CDCI3], 400 MHz Compound No. 23, solvent: [CDCl3], 400 MHz
9,6164 (0,9); 8,4008 (5,87); 7,2652 (38,73); 7,2153 (0,48); 5,2991 (2,8); 3,7725 (0,35); 3,7705 (0,35); 3,7662 (0,89); 3,7625 (4,54); 3,7605 (2,77); 3,7562 (2,66); 3,7522 9.6164 (0.9); 8,4008 (5.87); 7.2652 (38.73); 7.2153 (0.48); 5.2991 (2.8); 3.7725 (0.35); 3.7705 (0.35); 3.7662 (0.89); 3.7625 (4.54); 3.7605 (2.77); 3.7562 (2.66); 3.7522
(3,62); 3,7459 (1 1 ,05); 3,7398 (3,86); 3,7377 (2,61 ); 3,7356 (2,69); 3,7309 (3,35);(3.62); 3,7459 (1 1, 05); 3,7398 (3.86); 3.7377 (2.61); 3,7356 (2.69); 3.7309 (3.35);
3,7292 (4,8); 3,7256 (1 ,2); 3,4986 (1 ,33); 3,481 (2,76); 3,4674 (2,77); 3,4497 (1 ,48);3,7292 (4,8); 3,7256 (1, 2); 3.4986 (1, 33); 3,481 (2.76); 3.4674 (2.77); 3,4497 (1, 48);
3,2253 (4,34); 3,2069 (5,71 ); 3,1881 (4,65); 2,3775 (16,95); 2,1525 (17,14); 1 ,88793,2253 (4,34); 3.2069 (5.71); 3,1881 (4,65); 2.3775 (16.95); 2,1525 (17,14); 1, 8879
(0,35); 1 ,8744 (0,83); 1 ,87 (4,62); 1 ,8623 (4,32); 1 ,8534 (13,01 ); 1 ,8485 (3,12); 1 ,8448 (4,22); 1 ,8368 (4,46); 1 ,8203 (0,52); 1 ,7593 (0,59); 1 ,7425 (1 ,21 ); 1 ,7257 (1 ,61 ); (0.35); 1, 8744 (0.83); 1, 87 (4.62); 1, 8623 (4,32); 1, 8534 (13.01); 1, 8485 (3.12); 1, 8448 (4,22); 1, 8368 (4,46); 1, 8203 (0.52); 1, 7593 (0.59); 1, 7425 (1, 21); 1, 7257 (1, 61);
1 ,7088 (1 ,41 ); 1 ,6922 (0,89); 1 ,6784 (1 ,01 ); 1 ,6617 (1 ,9); 1 ,645 (2,49); 1 ,6283 (2,18); 1, 7088 (1, 41); 1, 6922 (0.89); 1, 6784 (1, 01); 1, 6617 (1, 9); 1, 645 (2.49); 1, 6283 (2,18);
1 ,61 16 (1 ,25); 1 ,5951 (0,46); 1 ,5322 (2,05); 1 ,5146 (4,95); 1 ,4966 (4,75); 1 ,47911, 61 16 (1, 25); 1, 5951 (0.46); 1, 5322 (2.05); 1, 5146 (4.95); 1, 4966 (4.75); 1, 4791
(1 ,78); 1 ,4652 (2,76); 1 ,4477 (5,04); 1 ,4317 (3,87); 1 ,4282 (5,1 1 ); 1 ,4109 (2,26); (1, 78); 1, 4652 (2.76); 1, 4477 (5,04); 1, 4317 (3,87); 1, 4282 (5.1 1); 1, 4109 (2.26);
0,9759 (0,35); 0,9572 (32,09); 0,9407 (30,84); 0,9246 (50); 0,9081 (47,57); 0,8909 (0,89); 0,8748 (0,74); 0,8582 (0,64); -0,0002 (7,32);  0.9759 (0.35); 0.9572 (32.09); 0.9407 (30.84); 0.9246 (50); 0.9081 (47.57); 0.8909 (0.89); 0.8748 (0.74); 0.8582 (0.64); -0,0002 (7,32);
Verbindung Nr. 40, Lösungsmittel: [CDCI3], 400 MHz Compound No. 40, solvent: [CDCl3], 400 MHz
13,1285 (0,7); 9,5733 (1 ,15); 9,5517 (1 ,18); 8,398 (8,23); 7,2655 (23,81 ); 7,2649 13.1285 (0.7); 9.5733 (1, 15); 9.5517 (1, 18); 8,398 (8,23); 7.2655 (23.81); 7.2649
(23,5); 4,033 (0,56); 4,0277 (0,68); 4,014 (1 ,22); 3,9935 (1 ,25); 3,9799 (0,7); 3,9743 (0,6); 3,9607 (0,3); 3,5238 (0,55); 3,5053 (1 ,46); 3,4916 (2,42); 3,4778 (1 ,52); 3,4597(23.5); 4.033 (0.56); 4.0277 (0.68); 4.014 (1, 22); 3.9935 (1, 25); 3.9799 (0.7); 3.9743 (0.6); 3.9607 (0.3); 3.5238 (0.55); 3,5053 (1, 46); 3.4916 (2.42); 3,4778 (1, 52); 3.4597
(0,64); 2,3654 (21 ,39); 2,1436 (22,03); 2,0052 (0,33); 1 ,6918 (0,32); 1 ,6732 (1 ,16);(0.64); 2,3654 (21, 39); 2,1436 (22.03); 2,0052 (0.33); 1, 6918 (0.32); 1, 6732 (1, 16);
1 ,6583 (1 ,59); 1 ,655 (1 ,56); 1 ,6392 (2,84); 1 ,625 (2,21 ); 1 ,6203 (2,45); 1 ,6066 (2,06);1, 6583 (1, 59); 1, 655 (1, 56); 1, 6392 (2.84); 1, 625 (2.21); 1, 6203 (2.45); 1, 6066 (2.06);
1 ,5939 (0,82); 1 ,5882 (0,77); 1 ,5752 (2,28); 1 ,5616 (3,06); 1 ,557 (3,05); 1 ,5437 (5,44);1, 5939 (0.82); 1, 5882 (0.77); 1, 5752 (2.28); 1, 5616 (3.06); 1, 557 (3.05); 1, 5437 (5.44);
1 ,5414 (5,39); 1 ,5269 (7,78); 1 ,5226 (4,89); 1 ,5087 (6,98); 1 ,4909 (3,51 ); 1 ,4737 (1 ,67); 1 ,4554 (0,47); 1 ,4319 (1 ,23); 1 ,4303 (1 ,25); 1 ,4098 (4,08); 1 ,3913 (6,69); 1, 5414 (5.39); 1, 5269 (7.78); 1, 5226 (4,89); 1, 5087 (6.98); 1,4909 (3.51); 1, 4737 (1, 67); 1, 4554 (0.47); 1, 4319 (1, 23); 1, 4303 (1, 25); 1, 4098 (4.08); 1, 3913 (6.69);
1 ,3732 (5,85); 1 ,3565 (4,76); 1 ,3381 (3,08); 1 ,3197 (0,86); 0,9677 (13,18); 0,9493 1, 3732 (5.85); 1, 3565 (4.76); 1, 3381 (3.08); 1, 3197 (0.86); 0.9677 (13.18); .9493
(27,32); 0,9308 (36,6); 0,9125 (50); 0,8938 (21 ,92); 0,7538 (0,31 ); 0,0004 (3,01 ); -(27.32); 0.9308 (36.6); 0.9125 (50); 0.8938 (21, 92); 0.7538 (0.31); 0.0004 (3.01); -
0,0002 (3,01 ); -0,0017 (2,38); Verbindung Nr.43, Lösungsmittel: [CDCI3], 400 MHz 0.0002 (3.01); -0.0017 (2.38); Compound No. 43, solvent: [CDCl3], 400 MHz
13,1238 (0,35); 9,7995 (0,36); 9,7859 (0,66); 9,7727 (0,38); 9,7537 (0,74); 8,3893 (4,09); 8,3806 (0,49); 7,261 (42,51); 6,3043 (0,48); 6,2985 (0,45); 6,2654 (0,39);  13.1238 (0.35); 9.7995 (0.36); 9.7859 (0.66); 9.7727 (0.38); 9.7537 (0.74); 8,3893 (4.09); 8.3806 (0.49); 7.261 (42.51); 6.3043 (0.48); 6.2985 (0.45); 6.2654 (0.39);
6,2593 (0,46); 4,5206 (1,32); 4,5164 (0,43); 4,5072 (3,12); 4,5031 (0,88); 4,4939 (1 ,43); 4,49 (0,44); 4,4026 (0,52); 4,3904 (0,51 ); 3,7425 (1 ,27); 3,7292 (1 ,28); 3,6445 (2,53); 3,6306 (4,43); 3,6168 (2,5); 3,4899 (0,31); 3,4194 (13,62); 3,4171 (50); 3,4 (0,34); 3,3922 (0,95); 3,367 (0,35); 2,4348 (0,98); 2,4132 (9,77); 2,1609 (1,16); 2,1501 (10,71); 2,0041 (0,62); 1,6154 (0,48); 1,4319 (1,84); -0,0002 (5,54); Verbindung Nr.52, Lösungsmittel: [CDCI3], 400 MHz 6.2593 (0.46); 4.5206 (1.32); 4.5164 (0.43); 4,5072 (3,12); 4.5031 (0.88); 4,4939 (1, 43); 4.49 (0.44); 4.4026 (0.52); 4.3904 (0.51); 3,7425 (1, 27); 3,7292 (1, 28); 3.6445 (2.53); 3,6306 (4,43); 3.6168 (2.5); 3.4899 (0.31); 3,4194 (13.62); 3,4171 (50); 3.4 (0.34); 3.3922 (0.95); 3,367 (0.35); 2.4348 (0.98); 2.4132 (9.77); 2,1609 (1.16); 2,1501 (10.71); 2.0041 (0.62); 1.6154 (0.48); 1.4319 (1.84); -0,0002 (5.54); Compound No. 52, solvent: [CDCl3], 400 MHz
13,1021 (0,32); 9,6407 (0,83); 9,6216 (0,85); 8,4323 (6,07); 7,2627 (50); 5,3016 (1,06); 4,3793 (0,35); 4,3678 (0,73); 4,3509 (0,87); 4,3481 (0,9); 4,3312 (0,79); 4,3198 (0,39); 3,4636 (7,06); 3,4521 (7); 3,4191 (0,35); 3,3869 (29,76); 2,4129 (15,67); 2,1668 (15,93); 1,2883 (10,92); 1,2715 (10,96); 0,008 (0,44); -0,0002 (18,44); -0,0085 (0,69);  13,1021 (0.32); 9.6407 (0.83); 9.6216 (0.85); 8,4323 (6,07); 7,2627 (50); 5.3016 (1.06); 4,3793 (0.35); 4,3678 (0.73); 4.3509 (0.87); 4.3481 (0.9); 4.3312 (0.79); 4.3198 (0.39); 3.4636 (7.06); 3,4521 (7); 3.4191 (0.35); 3,3869 (29.76); 2.4129 (15.67); 2,1668 (15,93); 1.2883 (10.92); 1.2715 (10.96); 0.008 (0.44); -0,0002 (18,44); -0.0085 (0.69);
Verbindung Nr.54, Lösungsmittel: [CDCI3], 400 MHz Compound No.54, solvent: [CDCl3], 400 MHz
12,7486 (0,39); 9,5584 (1,94); 8,4212 (9,85); 7,2705 (11,68); 7,2674 (23,68); 3,5564 (2,59); 3,5403 (6,31); 3,5251 (6,77); 3,5076 (3,69); 3,5015 (5,71); 3,486 (11,35);  12,7486 (0.39); 9.5584 (1.94); 8,4212 (9,85); 7.2705 (11.68); 7.2674 (23.68); 3.5564 (2.59); 3,5403 (6,31); 3.5251 (6.77); 3.5076 (3.69); 3.5015 (5.71); 3,486 (11.35);
3,4707 (5,61); 3,4494 (0,7); 3,4325 (0,5); 3,4177 (1,26); 3,3847 (4,24); 3,3571 (40,1); 2,394 (0,6); 2,3583 (27,12); 2,2708 (0,31); 2,1954 (0,48); 2,1489 (29,81); 2,111 (50); 1 ,9064 (1 ,42); 1 ,8905 (4,92); 1 ,8744 (7,12); 1 ,8583 (4,61 ); 1 ,8421 (1 ,22); 1 ,2774 (1,77); 1,2604 (1,93); -0,0002 (2,72); 3,4707 (5.61); 3.4494 (0.7); 3.4325 (0.5); 3.4177 (1.26); 3,3847 (4,24); 3,3571 (40,1); 2.344 (0.6); 2,3583 (27,12); 2.2708 (0.31); 2.1954 (0.48); 2,1489 (29.81); 2,111 (50); 1, 9064 (1, 42); 1, 8905 (4.92); 1, 8744 (7.12); 1, 8583 (4.61); 1, 8421 (1, 22); 1, 2774 (1.77); 1.2604 (1.93); -0.0002 (2.72);
Verbindung Nr.36, Lösungsmittel: [CDCI3], 400 MHz Compound No. 36, solvent: [CDCl3], 400 MHz
12,682 (0,3); 9,3598 (1 ,36); 9,3396 (1 ,39); 8,4146 (9,36); 7,2607 (50); 4,2592 (0,54);12,682 (0.3); 9,3598 (1, 36); 9,3396 (1, 39); 8,4146 (9,36); 7.2607 (50); 4.2592 (0.54);
4,2383 (1,15); 4,2227 (1,61); 4,207 (1,14); 4,1862 (0,59); 2,3525 (25,84); 2,142 4,2383 (1.15); 4.2227 (1.61); 4,207 (1,14); 4.1862 (0.59); 2.3525 (25.84); 2,142
(25,58); 2,1135 (29,73); 2,0039 (0,35); 1 ,7339 (0,69); 1 ,7172 (1 ,24); 1 ,6979 (1 ,6);  (25.58); 2,1135 (29.73); 2.0039 (0.35); 1, 7339 (0.69); 1, 7172 (1, 24); 1, 6979 (1, 6);
1 ,6813 (1 ,52); 1 ,6649 (0,98); 1 ,648 (0,42); 1 ,5157 (1 ,21 ); 1 ,5005 (1 ,11 ); 1 ,4942 (1 ,24); 1, 6813 (1, 52); 1, 6649 (0.98); 1, 648 (0.42); 1, 5157 (1, 21); 1, 5005 (1,11); 1, 4942 (1, 24);
1,4805 (2,02); 1,4665(1,57); 1,4601 (1,74); 1,4449(1,44); 1,3511 (1,57); 1,3365 (1,69); 1,3309(1,62); 1,3165(2,46); 1,3024 (1,15); 1,2966 (1,14); 1,2821 (1,01); 1.4805 (2.02); 1.4665 (1.57); 1.4601 (1.74); 1.4449 (1.44); 1.3511 (1.57); 1.3365 (1.69); 1.3309 (1.62); 1.3165 (2.46); 1.3024 (1.15); 1.2966 (1.14); 1.2821 (1.01);
1,2207 (15,14); 1,2045 (15,14); 0,9341 (16,43); 0,9288 (17,72); 0,9178 (16,31); 0,9122 1,2207 (15,14); 1,2045 (15:14); 0.9341 (16.43); 0.9288 (17.72); 0.9178 (16.31); .9122
(16,86); -0,0002 (5,64); Verbindung Nr. 37, Lösungsmittel: [CDCI3], 400 MHz (16,86); -0.0002 (5.64); Compound No. 37, solvent: [CDCl3], 400 MHz
8,4096 (2,36); 7,2605 (31 ,03); 7,2594 (50); 2,365 (6,08); 2,1438 (6,37); 1 ,5424 (2,69); 1 ,1652 (4,24); 1 ,1483 (4,21 ); 0,9751 (24,03); 0,001 1 (3,62); 0 (5,97); Verbindung Nr. 38, Lösungsmittel: [CDCI3], 400 MHz  8.4096 (2.36); 7,2605 (31, 03); 7,2594 (50); 2,365 (6.08); 2,1438 (6,37); 1, 5424 (2.69); 1, 1652 (4,24); 1, 1483 (4,21); 0.9751 (24.03); 0.001 1 (3.62); 0 (5.97); Compound No. 38, solvent: [CDCl3], 400 MHz
9,4461 (0,54); 9,426 (0,56); 8,434 (5,09); 7,264 (15,25); 7,2625 (1 1 ,66); 4,0822 (0,55); 4,0651 (0,73); 4,0606 (0,62); 4,0517 (0,61 ); 4,0472 (0,75); 4,0441 (0,67); 4,0302 (0,56); 2,3524 (14,02); 2,1472 (13,69); 2,1072 (50); 2,106 (39,89); 2,0984 (0,98);  9.4661 (0.54); 9.466 (0.56); 8,434 (5.09); 7,264 (15,25); 7,2625 (1 1, 66); 4.0822 (0.55); 4.0651 (0.73); 4.0606 (0.62); 4.0517 (0.61); 4.0472 (0.75); 4.0441 (0.67); 4.0302 (0.56); 2.3524 (14.02); 2,1472 (13.69); 2,1072 (50); 2,106 (39,89); 2.0984 (0.98);
1 ,8236 (0,62); 1 ,8066 (0,93); 1 ,7928 (0,9); 1 ,7759 (0,66); 1 ,1686 (8,9); 1 ,1519 (8,96); 0,9621 (8,64); 0,9458 (13,41 ); 0,9303 (8,51 ); -0,0002 (2,25); -0,0016 (1 ,66); 1, 8236 (0.62); 1, 8066 (0.93); 1, 7928 (0.9); 1, 7759 (0.66); 1, 1686 (8,9); 1, 1519 (8, 96); 0.9621 (8.64); 0.9458 (13.41); 0.9303 (8.51); -0,0002 (2.25); -0.0016 (1, 66);
Verbindung Nr. 45, Lösungsmittel: [DMSO], 400 MHz Compound No. 45, solvent: [DMSO], 400 MHz
12,2949 (1 ,07); 9,8598 (1 ,82); 8,1067 (9,54); 3,4985 (3,89); 3,484 (8,91 ); 3,4699 (6,29); 3,3829 (50); 3,3539 (14,97); 3,3396 (9,64); 3,3251 (4,19); 3,1707 (1 ,54); 2,5121 (12,08); 2,5077 (27,13); 2,5032 (39,16); 2,4986 (28,67); 2,494 (13,78); 2,2439 (21 ,96); 2,071 1 (0,81 ); 2,0486 (22,52); -0,0002 (2,02);  12, 2949 (1, 07); 9.8598 (1, 82); 8,1067 (9.54); 3.4985 (3.89); 3,484 (8.91); 3.4699 (6.29); 3,3829 (50); 3.3539 (14.97); 3,3396 (9,64); 3,3251 (4,19); 3,1707 (1, 54); 2.5121 (12.08); 2,5077 (27,13); 2.5032 (39.16); 2.4986 (28.67); 2,494 (13.78); 2,2439 (21, 96); 2.071 1 (0.81); 2.0486 (22.52); -0.0002 (2.02);
Verbindung Nr. 46, Lösungsmittel: [CDCI3], 400 MHz Compound No. 46, solvent: [CDCl3], 400 MHz
13,0823 (1 ,02); 9,8798 (1 ,77); 8,3944 (9,57); 7,3098 (0,62); 7,2628 (47,69); 7,2605 (50); 3,6825 (1 ,85); 3,6691 (5,61 ); 3,6562 (6,74); 3,6435 (3,18); 3,6323 (0,33); 3,5855 (6,44); 3,573 (8,08); 3,5597 (3,53); 3,4924 (0,3); 3,4634 (0,4); 3,4364 (0,43); 3,3894 (34,13); 3,3872 (34,6); 3,3595 (1 ,65); 3,3573 (1 ,6); 2,405 (26,14); 2,1979 (0,37);  13.0823 (1, 02); 9.8798 (1, 77); 8.3944 (9.57); 7.3098 (0.62); 7.2628 (47.69); 7.2605 (50); 3.6825 (1, 85); 3,6691 (5.61); 3,6562 (6,74); 3.6435 (3.18); 3,6323 (0.33); 3.5855 (6.44); 3,573 (8.08); 3.5597 (3.53); 3.4924 (0.3); 3.4634 (0.4); 3.4364 (0.43); 3,3894 (34,13); 3.3872 (34.6); 3.3595 (1, 65); 3,3573 (1, 6); 2,405 (26,14); 2.1979 (0.37);
2,1512 (26,89); 2,004 (0,65); 1 ,5872 (2,89); 0,0021 (6,22); -0,0002 (6,64); Verbindung Nr. 59, Lösungsmittel: [DMSO], 400 MHz 2,1512 (26,89); 2.004 (0.65); 1, 5872 (2.89); 0.0021 (6.22); -0.0002 (6.64); Compound No. 59, solvent: [DMSO], 400 MHz
12,4036 (0,93); 10,0757 (0,8); 10,0614 (1 ,66); 10,0469 (0,89); 9,0939 (0,51 ); 8,1033 (7,72); 7,6968 (1 ,15); 7,6937 (1 ,14); 4,1 149 (7,43); 4,1004 (7,51 ); 3,748 (0,33); 3,6936 (0,37); 3,6437 (32,78); 3,4572 (0,48); 3,3683 (48,13); 3,1691 (7,28); 3,0981 (0,66); 3,086 (0,66); 3,0799 (0,68); 3,0679 (0,66); 2,5513 (0,35); 2,524 (0,54); 2,5192 (0,74); 2,5107 (15,78); 2,5061 (35,24); 2,5015 (50); 2,4969 (35,83); 2,4924 (16,86); 2,2596 (17,82); 2,0713 (1 ,15); 2,0554 (19,1 1 ); 1 ,9085 (5,06); 1 ,2046 (1 ,43); 1 ,1864 (2,98); 1 ,1681 (1 ,38); -0,0002 (2,02); Verbindung Nr.67, Lösungsmittel: [CDCI3], 400 MHz 12.4036 (0.93); 10.0757 (0.8); 10.0614 (1, 66); 10.0469 (0.89); 9.0939 (0.51); 8,1033 (7,72); 7, 6968 (1, 15); 7, 6937 (1, 14); 4.1 149 (7.43); 4,1004 (7.51); 3,748 (0.33); 3.6936 (0.37); 3,6437 (32.78); 3.4572 (0.48); 3,3683 (48,13); 3,1691 (7,28); 3.0981 (0.66); 3.086 (0.66); 3.0799 (0.68); 3.0679 (0.66); 2.5513 (0.35); 2,524 (0.54); 2.5192 (0.74); 2,5107 (15,78); 2,5061 (35,24); 2.5015 (50); 2.4969 (35.83); 2,4924 (16,86); 2.2596 (17.82); 2.0713 (1, 15); 2.0554 (19.1 1); 1, 9085 (5.06); 1, 2046 (1, 43); 1, 1864 (2.98); 1, 1681 (1, 38); -0.0002 (2.02); Compound No.67, solvent: [CDCl3], 400 MHz
13,0683 (0,47); 12,5279 (1,36); 8,4287 (6,22); 8,4216 (0,6); 7,2611 (50); 7,2094 (0,41); 5,1639 (0,38); 4,5331 (0,69); 4,5161 (0,4); 4,3687 (11,48); 4,2536 (0,69); 4,1879 (0,53); 4,1791 (0,84); 4,0932 (1,34); 4,0873 (0,5); 3,8932 (0,35); 3,7173 (1,21); 3,666 (0,78); 3,5098 (1 ,86); 3,5042 (29,69); 3,4998 (3,12); 3,4909 (0,78); 3,4807 (1 ,09);  13.0683 (0.47); 12.5279 (1.36); 8,4287 (6,22); 8.4216 (0.6); 7,2611 (50); 7.2094 (0.41); 5.1639 (0.38); 4.5331 (0.69); 4.5161 (0.4); 4,3687 (11,48); 4.2536 (0.69); 4.1879 (0.53); 4.1791 (0.84); 4.0932 (1.34); 4.0873 (0.5); 3.8932 (0.35); 3.7173 (1.21); 3,666 (0.78); 3.5098 (1, 86); 3.5042 (29.69); 3.4998 (3.12); 3.4909 (0.78); 3,4807 (1, 09);
3,4684 (0,75); 3,4355 (0,81); 3,4272 (1,26); 3,3817 (1,31); 3,3687 (0,7); 3,3063 (0,82); 3,1316 (0,46); 3,1132 (0,47); 2,4989 (0,42); 2,4682 (16,41); 2,4254 (0,99); 2,417 (0,71); 2,202 (0,54); 2,1884 (16,9); 2,1634 (1,18); 2,1171 (0,3); 2,0045 (1,35); 1,5731 (0,35); 1,4232 (0,59); 1,4049 (1,12); 1,3865 (0,55); -0,0002 (5,43);  3.4684 (0.75); 3.4355 (0.81); 3.4272 (1.26); 3.3817 (1.31); 3.3687 (0.7); 3.3063 (0.82); 3.1316 (0.46); 3,1132 (0.47); 2.4989 (0.42); 2.4682 (16.41); 2.4254 (0.99); 2,417 (0.71); 2.202 (0.54); 2,1884 (16,9); 2,1634 (1,18); 2.1171 (0.3); 2.0045 (1.35); 1.5731 (0.35); 1.4232 (0.59); 1.4049 (1.12); 1.3865 (0.55); -0,0002 (5.43);
Verbindung Nr.359, Lösungsmittel: [DMSO], 400 MHz Compound No. 359, solvent: [DMSO], 400 MHz
12,9647 (0,77); 8,2528 (8,24); 3,5306 (0,94); 3,5104 (1,82); 3,4937 (1,9); 3,4735 (0,97); 3,3209 (3,11); 2,6758 (0,34); 2,6711 (0,48); 2,6665 (0,35); 2,5246 (1,3); 2,5199 (1,83); 2,5112 (28,79); 2,5067 (62,05); 2,5021 (85,33); 2,4975 (60,2); 2,493 (27,42); 2,3718 (7,82); 2,3384 (0,36); 2,3335 (0,48); 2,329 (0,58); 2,3245 (0,42); 1 ,3569 (1 ,38); 1,232 (16); 1,2153 (15,85); 1,1489 (0,33); 1,0294 (0,35); 1,0172 (0,7); 1,0091 (1,02); 1,0052 (0,58); 0,9968 (1,98); 0,9887 (1,23); 0,9846 (1,27); 0,9765 (2,08); 0,9681 (0,63); 0,9641 (1,15); 0,9561 (0,77); 0,9439 (0,39); 0,502 (0,48); 0,4938 (0,61); 0,4899 (0,68); 0,4812 (1,69); 0,4717 (1 ,56); 0,4682 (1,55); 0,4597 (2,14); 0,4511 (1,07);  12.9647 (0.77); 8,2528 (8,24); 3.5306 (0.94); 3.5104 (1.82); 3.4937 (1.9); 3.4735 (0.97); 3,3209 (3,11); 2.6758 (0.34); 2.6711 (0.48); 2.6665 (0.35); 2.5246 (1.3); 2.5199 (1.83); 2.5112 (28.79); 2.5067 (62.05); 2.5021 (85.33); 2,4975 (60.2); 2,493 (27,42); 2.3718 (7.82); 2.3384 (0.36); 2.3335 (0.48); 2.329 (0.58); 2.3245 (0.42); 1, 3569 (1, 38); 1,232 (16); 1.2153 (15.85); 1.1489 (0.33); 1.0294 (0.35); 1.0172 (0.7); 1,0091 (1.02); 1.0052 (0.58); 0.9968 (1.98); 0.9887 (1.23); 0.9846 (1.27); 0.9765 (2.08); 0.9681 (0.63); 0.9641 (1.15); 0.9561 (0.77); 0.9439 (0.39); 0.502 (0.48); 0.4938 (0.61); 0.4899 (0.68); 0.4812 (1.69); 0.4717 (1, 56); 0.4682 (1.55); 0.4597 (2.14); 0.4511 (1.07);
0,4469 (1 ,21 ); 0,4384 (1,12); 0,4321 (1 ,09); 0,4228 (1 ,29); 0,4197 (1 ,28); 0,4099 (1,76); 0,3999 (1,77); 0,3895 (1,85); 0,3808 (0,67); 0,3773 (0,71); 0,3683 (0,67); 0.4969 (1, 21); 0.4384 (1.12); 0.4321 (1, 09); 0.4228 (1, 29); 0.4197 (1, 28); 0.4099 (1.76); 0.3999 (1.77); 0.3895 (1.85); 0.3808 (0.67); 0.3773 (0.71); 0.3683 (0.67);
0,3193 (0,6); 0,307 (1,05); 0,2971 (1,65); 0,2844 (2,41); 0,2748 (2,3); 0,2655 (1,61); 0,2627 (1,51); 0,2572 (1,53); 0,2535 (2,35); 0,2447 (2,11); 0,2319 (1 ,37); 0,222 (0,94); 0,2186 (0,57); 0,2096 (0,47); 0,0082 (0,79); 0.3193 (0.6); 0.307 (1.05); 0.2971 (1.65); 0.2844 (2.41); 0.2748 (2.3); 0.2655 (1.61); 0.2627 (1.51); 0.2572 (1.53); 0.2535 (2.35); 0.2447 (2.11); 0.2319 (1, 37); 0.222 (0.94); 0.2186 (0.57); 0.2096 (0.47); 0.0082 (0.79);
Verbindung Nr.250, Lösungsmittel: [DMSO], 400 MHz Compound No. 250, solvent: [DMSO], 400 MHz
18,1302 (0,33); 17,8361 (0,38); 17,7326 (0,33); 16,8803 (0,36); 16,8757 (0,32); 8,7145 (0,34); 8,2739 (7,49); 3,8925 (0,32); 3,5322 (1,04); 3,5121 (1,71); 3,4953 (1,83);  18.1302 (0.33); 17.8361 (0.38); 17,7326 (0.33); 16,8803 (0.36); 16.8757 (0.32); 8.7145 (0.34); 8.2739 (7.49); 3.8925 (0.32); 3.5322 (1.04); 3.5121 (1.71); 3.4953 (1.83);
3,4751 (0,87); 3,4583 (0,36); 3,4406 (0,41); 3,3971 (1,38); 3,342 (91,18); 3,198 (0,38); 3,1708 (0,38); 3,1501 (0,36); 3,1457 (0,51); 3,1412 (0,59); 3,1366 (0,56); 3,132 (0,4); 3,1021 (0,33); 3,0547 (0,34); 2,8005 (0,45); 2,7518 (0,35); 2,7199 (0,37); 2,6768 (0,4); 2,6723 (0,52); 2,6677 (0,34); 2,5632 (0,47); 2,5586 (0,65); 2,5539 (0,48); 2,5391 (0,39); 2,5256 (1,89); 2,5209 (2,87); 2,5124 (36,97); 2,5078 (78,21); 2,5032 (105,6); 2,4986 (71,37); 2,494 (29,64); 2,3891 (4,93); 2,3807 (9,32); 2,3719 (4,76); 2,3346 (0,43); 2,3301 (0,64); 2,3255 (0,49); 1,9663 (0,37); 1,3567 (1,08); 1,235 (16); 1,2183 (15,53); 1,0331 (0,35); 1,021 (0,77); 1,0129(1,03); 1,0087(0,53); 1,0007(1,92); 3.4751 (0.87); 3.4583 (0.36); 3.4406 (0.41); 3.3971 (1.38); 3,342 (91.18); 3,198 (0.38); 3.170 (0.38); 3.1501 (0.36); 3.1457 (0.51); 3.1412 (0.59); 3.1366 (0.56); 3,132 (0.4); 3,1021 (0.33); 3.0547 (0.34); 2.8005 (0.45); 2.7518 (0.35); 2,7199 (0.37); 2.6768 (0.4); 2.6723 (0.52); 2.6677 (0.34); 2.5632 (0.47); 2.5586 (0.65); 2.5539 (0.48); 2.5391 (0.39); 2.5256 (1.89); 2,5209 (2,87); 2.5124 (36.97); 2.5078 (78.21); 2.5032 (105.6); 2,4986 (71,37); 2,494 (29.64); 2.3891 (4.93); 2,3807 (9.32); 2.379 (4.76); 2.3346 (0.43); 2.3301 (0.64); 2.3255 (0.49); 1.9663 (0.37); 1.3567 (1.08); 1,235 (16); 1.2183 (15.53); 1.0331 (0.35); 1.021 (0.77); 1.0129 (1.03); 1.0087 (0.53); 1.0007 (1.92);
0,9924 (1,14); 0,9884 (1,18); 0,9803 (2,04); 0,9721 (0,57); 0,968 (1,1); 0,9599 (0,74); 0,9477 (0,33); 0,505 (0,51); 0,497 (0,65); 0,493 (0,69); 0,4843 (1,65); 0,4747 (1,44); 0,471 (1,34); 0,4627 (1,94); 0,4541 (0,94); 0,4499 (1,1); 0,4414 (1,03); 0,4332 (1,02); 0,424 (1,26); 0,4207 (1,21); 0,4109 (1,64); 0,4039 (1,27); 0,401 (1,53); 0,3906 (1,75); 0,382 (0,56); 0,3784 (0,57); 0,3695 (0,61); 0,3217 (0,58); 0,3092 (1,04); 0,2993 (1,6); 0,2865 (2,3); 0,2771 (2,23); 0,2737 (1,28); 0,2682 (1,4); 0,2649 (1,26); 0,2599 (1,33); 0,2561 (2,13); 0,2474 (1,87); 0,2346 (1,16); 0,2245 (0,79); 0,2123 (0,37); 0,0082 (1,29); 0 (36,67); 0.9924 (1.14); 0.9884 (1.18); 0.9803 (2.04); 0.9721 (0.57); 0.968 (1.1); 0.9599 (0.74); 0.9477 (0.33); 0.505 (0.51); 0.497 (0.65); 0.493 (0.69); 0.4843 (1.65); 0.4747 (1.44); 0.471 (1.34); 0.4627 (1.94); 0.4541 (0.94); 0.4499 (1.1); 0.4414 (1.03); 0.4332 (1.02); 0.424 (1.26); 0.4207 (1.21); 0.4109 (1.64); 0.4039 (1.27); 0.401 (1.53); 0.3906 (1.75); 0.382 (0.56); 0.3784 (0.57); 0.3695 (0.61); 0.3217 (0.58); 0.3092 (1.04); 0.2993 (1.6); 0.2865 (2.3); 0.2771 (2.23); 0.2737 (1.28); 0.2682 (1.4); 0.2649 (1.26); 0.2599 (1.33); 0.2561 (2.13); 0.2474 (1.87); 0.2346 (1.16); 0.2245 (0.79); 0.2123 (0.37); 0.0082 (1.29); 0 (36,67);
Verbindung Nr.360, Lösungsmittel: [DMSO], 400 MHz Compound No. 360, solvent: [DMSO], 400 MHz
12,7674 (0,53); 8,1683 (6,25); 6,5471 (0,56); 6,524 (0,6); 6,509 (0,58); 6,486 (0,54); 4,9013 (0,33); 4,8827 (0,96); 4,8641 (1,5); 4,8453 (1,46); 4,8237 (0,95); 4,8051 (0,36); 4,4416 (0,5); 4,4241 (0,52); 4,4079 (0,47); 3,3066 (6,28); 2,6756 (0,42); 2,6712 (0,57); 2,6666 (0,4); 2,5867 (0,37); 2,5244 (1,41); 2,5193 (2,12); 2,5109 (35,71); 2,5065 (74,62); 2,502 (100); 2,4976 (70,67); 2,4933 (32,78); 2,3769 (6,55); 2,3687 (12,54); 2,3601 (6,87); 2,3335 (0,6); 2,3291 (0,69); 2,3246 (0,5); 1,3564 (16); 1,3387 (14,98); 1,2262 (4,52); 1,2231 (4,37); 1,2085 (4,54); 1,2055 (4,36); 0,0081 (0,95); 0 (31);  12,7674 (0.53); 8,1683 (6,25); 6.5471 (0.56); 6.524 (0.6); 6.509 (0.58); 6,486 (0.54); 4.9013 (0.33); 4,8827 (0.96); 4.8641 (1.5); 4.8483 (1.46); 4,8237 (0.95); 4,8051 (0.36); 4,4416 (0.5); 4,4241 (0.52); 4,4079 (0.47); 3,3066 (6,28); 2.6756 (0.42); 2.6712 (0.57); 2.6666 (0.4); 2.5867 (0.37); 2.5244 (1.41); 2,5193 (2,12); 2.5109 (35.71); 2.5065 (74.62); 2,502 (100); 2.4976 (70.67); 2.4933 (32.78); 2.3769 (6.55); 2.3687 (12.54); 2.3601 (6.87); 2.3335 (0.6); 2.3291 (0.69); 2.3246 (0.5); 1.3564 (16); 1.3387 (14.98); 1.2262 (4.52); 1.2231 (4.37); 1,2085 (4,54); 1,2055 (4,36); 0.0081 (0.95); 0 (31);
Verbindung Nr.1131, Lösungsmittel: [DMSO], 400 MHz Compound No.1131, solvent: [DMSO], 400 MHz
12,7693 (0,37); 9,0635 (0,44); 9,0546 (0,45); 8,2073 (7,59); 4,8855 (0,81); 4,8666 (1,26); 4,8461 (1,24); 4,8265 (0,85); 4,8073 (0,33); 3,3239 (7,1); 2,667 (2,22); 2,6615 (1,85); 2,6482 (3); 2,6354 (1,76); 2,6289 (2,01); 2,5562 (0,33); 2,5515 (0,43); 2,5244 (1 ,33); 2,5196 (1 ,9); 2,511 (35,73); 2,5065 (77,26); 2,502 (106,95); 2,4974 (76,79); 2,4929 (36,28); 2,4584 (0,45); 2,3333 (0,48); 2,3288 (0,66); 2,3243 (0,48); 2,086 (2,19); 1 ,613 (0,44); 1 ,5946 (1 ,72); 1 ,5757 (2,95); 1 ,5564 (3,03); 1 ,5376 (1 ,86); 1 ,5196 (0,53); 1,3617(13,04); 1,3441 (13,01); 0,9511 (7,63); 0,9329 (16); 0,9145 (6,91); 0 (7,62);  12,7693 (0.37); 9.0635 (0.44); 9.0546 (0.45); 8,2073 (7.59); 4.885 (0.81); 4,8666 (1.26); 4,8461 (1.24); 4.8265 (0.85); 4.8073 (0.33); 3,3239 (7.1); 2,667 (2.22); 2.6615 (1.85); 2,6482 (3); 2.6354 (1.76); 2.6289 (2.01); 2.5562 (0.33); 2.5515 (0.43); 2.5244 (1, 33); 2,5196 (1, 9); 2,511 (35.73); 2.5065 (77.26); 2,502 (106,95); 2.4974 (76.79); 2,4929 (36,28); 2.4584 (0.45); 2.3333 (0.48); 2.3288 (0.66); 2.3243 (0.48); 2,086 (2,19); 1, 613 (0.44); 1, 5946 (1, 72); 1, 5757 (2.95); 1, 5564 (3.03); 1, 5376 (1, 86); 1, 5196 (0.53); 1.3617 (13.04); 1.3441 (13.01); 0.9511 (7.63); 0.9329 (16); 0.9145 (6.91); 0 (7.62);
Verbindung Nr.141, Solvent: [DMSO], 400 MHz Compound No. 141, solvent: [DMSO], 400 MHz
9,0978 (0,34); 8,2144 (7,36); 4,9072 (0,42); 4,8886 (1,13); 4,8695 (1,71); 4,8488 (1,64); 4,8294 (1,12); 4,8111 (0,43); 3,325 (7,02); 3,2556 (0,94); 3,2339 (0,57); 3,1982 (0,33); 3,1687 (0,46); 3,0473 (0,35); 2,6763 (0,42); 2,6717 (0,56); 2,6672 (0,41); 2,5413 (0,37); 2,5251 (1 ,84); 2,5201 (2,79); 2,51 17 (35,87); 2,5072 (73,7); 2,5027 (98,89); 2,4982 (70,52); 2,4937 (33); 2,3578 (13,28); 2,3521 (13,35); 2,3467 (5,6); 2,3342 (0,81 ); 2,3297 (0,82); 2,3254 (0,61 ); 2,0863 (1 ,36); 1 ,3615 (16); 1 ,344 (15,87); 0,0081 (0,61 ); 9.0978 (0.34); 8,2144 (7,36); 4.9072 (0.42); 4.8886 (1.13); 4.8695 (1.71); 4.8488 (1.64); 4.8294 (1.12); 4.8111 (0.43); 3,325 (7.02); 3.2556 (0.94); 3.2339 (0.57); 3.1982 (0.33); 3.1687 (0.46); 3.0473 (0.35); 2.6763 (0.42); 2.6717 (0.56); 2.6672 (0.41); 2.5413 (0.37); 2.5251 (1, 84); 2,5201 (2.79); 2.51 17 (35.87); 2.5072 (73.7); 2.5027 (98.89); 2,4982 (70,52); 2,4937 (33); 2,3578 (13,28); 2,3521 (13,35); 2.3467 (5.6); 2.3342 (0.81); 2.3297 (0.82); 2.3254 (0.61); 2,0863 (1, 36); 1, 3615 (16); 1, 344 (15,87); 0.0081 (0.61);
Verbindung Nr. 251 , Lösungsmittel: [DMSO], 400 MHz Compound No. 251, solvent: [DMSO], 400 MHz
12,7416 (0,43); 12,726 (0,42); 9,0169 (0,79); 8,608 (1 ,55); 8,1698 (8,83); 4,9009 (0,42); 4,882 (1 ,17); 4,8628 (1 ,89); 4,8435 (1 ,9); 4,824 (1 ,24); 4,8046 (0,48); 3,696 (4,2); 3,6662 (0,44); 3,6492 (0,5); 3,5101 (2,05); 3,3366 (0,36); 2,6714 (0,54); 2,5562 (1 ,03); 2,5531 (1 ,07); 2,5027 (92,18); 2,466 (1 ,33); 2,3855 (8,3); 2,3775 (15,74); 2,369 (9,12); 2,3302 (0,73); 1 ,3568 (15,88); 1 ,3393 (16); 0,001 1 (16,75); 0 (17,8);  12.7416 (0.43); 12,726 (0.42); 9.0169 (0.79); 8,608 (1, 55); 8,1698 (8,83); 4.9009 (0.42); 4,882 (1,17); 4,8628 (1, 89); 4,8435 (1, 9); 4,824 (1, 24); 4.8046 (0.48); 3,696 (4,2); 3.6662 (0.44); 3.6492 (0.5); 3.5101 (2.05); 3.3366 (0.36); 2.6714 (0.54); 2.5562 (1, 03); 2.5531 (1, 07); 2,5027 (92,18); 2,466 (1, 33); 2.3855 (8.3); 2.3775 (15.74); 2,369 (9,12); 2.3302 (0.73); 1, 3568 (15,88); 1, 3393 (16); 0.001 1 (16.75); 0 (17.8);
Verbindung Nr. 169, Lösungsmittel: [CDCI3], 400 MHz Compound No. 169, solvent: [CDCl3], 400 MHz
9,7704 (0,39); 8,4552 (2,34); 7,5182 (1 ,07); 7,3093 (0,35); 7,2718 (0,34); 7,2675 (0,68); 7,2668 (0,72); 7,2594 (185,1 ); 6,9955 (1 ,04); 4,2454 (4,29); 4,2314 (4,3);  9.7704 (0.39); 8,4552 (2,34); 7,5182 (1, 07); 7.3093 (0.35); 7.2718 (0.34); 7.2675 (0.68); 7.2668 (0.72); 7.2594 (185.1); 6,9955 (1, 04); 4,2454 (4,29); 4,2314 (4,3);
3,7823 (16); 3,491 (0,37); 2,3413 (1 ,61 ); 2,3363 (4,77); 2,331 (4,95); 2,3258 (1 ,83); 1 ,6366 (0,41 ); 1 ,5526 (2,26); 0,0082 (1 ,97); 0 (71 ,54); 3,7823 (16); 3.491 (0.37); 2,3413 (1, 61); 2.3363 (4.77); 2,331 (4.95); 2.3258 (1, 83); 1, 6366 (0.41); 1, 5526 (2.26); 0.0082 (1, 97); 0 (71, 54);
Verbindung Nr. 2251 , Lösungsmittel: [CDCI3], 400 MHz Compound No. 2251, solvent: [CDCl3], 400 MHz
9,7332 (2,06); 9,7107 (2,06); 8,5156 (10,08); 7,5192 (0,55); 7,2627 (56,85); 7,26049.7332 (2.06); 9,7107 (2,06); 8.5156 (10.08); 7.5192 (0.55); 7,2627 (56,85); 7.2604
(101 ,3); 6,9964 (0,54); 4,9462 (0,52); 4,9277 (1 ,37); 4,9096 (2,05); 4,8914 (1 ,87);(101, 3); 6.9964 (0.54); 4.9462 (0.52); 4,9277 (1, 37); 4.9096 (2.05); 4,8914 (1, 87);
4,8867 (1 ,73); 4,869 (1 ,24); 4,8513 (0,52); 4,6822 (0,62); 4,6631 (0,81 ); 4,591 1 (1 ,94);4,8867 (1, 73); 4,869 (1, 24); 4.8513 (0.52); 4.6822 (0.62); 4.6631 (0.81); 4,591 1 (1, 94);
4,5746 (2,15); 4,5569 (2,05); 4,5391 (1 ,36); 4,5336 (1 ,1 ); 4,5158 (0,69); 3,748 (0,37);4.5746 (2.15); 4.5569 (2.05); 4,5391 (1, 36); 4.5336 (1, 1); 4.5158 (0.69); 3,748 (0.37);
2,5652 (0,33); 2,3595 (15,51 ); 2,0054 (0,85); 1 ,8551 (0,48); 1 ,6895 (0,4); 1 ,5785 (2,32); 1 ,4322 (2,33); 1 ,4188 (16); 1 ,4013 (15,76); 1 ,3298 (1 1 ,69); 1 ,3134 (9,68); 2.5652 (0.33); 2.3595 (15.51); 2.0054 (0.85); 1, 8551 (0.48); 1, 6895 (0.4); 1, 5785 (2.32); 1, 4322 (2.33); 1, 4188 (16); 1, 4013 (15, 76); 1, 3298 (1 1, 69); 1, 3134 (9.68);
0,0024 (13,37); 0 (23,26)  0.0024 (13.37); 0 (23,26)
Verbindung Nr. 397, Solvent: [DMSO], 400 MHz Compound No. 397, solvent: [DMSO], 400 MHz
12,9636 (3,26); 8,7957 (0,33); 8,7874 (0,36); 8,7731 (0,35); 8,7685 (0,36); 8,759 (0,35); 8,7446 (0,37); 8,7226 (0,35); 8,2482 (15,56); 5,5334 (0,49); 5,5108 (0,53); 3,2999 (77,15); 3,1678 (1 ,99); 3,1475 (4,73); 3,127 (4,82); 3,1067 (1 ,88); 2,9072 (0,51 ); 2,8845 (0,5); 2,6741 (0,88); 2,6697 (1 ,18); 2,6649 (0,89); 2,5397 (0,94); 2,5228 (2,55); 2,5096 (64,36); 2,5051 (138,28); 2,5006 (193,4); 2,4961 (143,28); 2,4917 (71 ,27); 2,3708 (16); 2,3317 (1 ,14); 2,3276 (1 ,39); 2,3229 (1 ,05); 2,0716 (0,59); 1 ,247 (0,48); 1,1017(1 ,08); 1 ,0893 (2,53); 1 ,0818 (3,64); 1 ,0692 (6,63); 1 ,0625 (4,27); 12,9636 (3,26); 8.7957 (0.33); 8.7874 (0.36); 8.7731 (0.35); 8.7685 (0.36); 8,759 (0.35); 8.7446 (0.37); 8.7226 (0.35); 8.2482 (15.56); 5.5334 (0.49); 5.5108 (0.53); 3,2999 (77.15); 3,1678 (1, 99); 3,1475 (4,73); 3,127 (4,82); 3,1067 (1, 88); 2.9072 (0.51); 2.8845 (0.5); 2.6741 (0.88); 2,6697 (1, 18); 2.6649 (0.89); 2.5397 (0.94); 2.5228 (2.55); 2.5096 (64.36); 2,5051 (138,28); 2,5006 (193.4); 2,4961 (143,28); 2,4917 (71, 27); 2,3708 (16); 2,3317 (1,14); 2,3276 (1, 39); 2,3229 (1, 05); 2.0716 (0.59); 1, 247 (0.48); 1,1017 (1, 08); 1, 0893 (2.53); 1, 0818 (3.64); 1, 0692 (6,63); 1, 0625 (4,27);
I, 0569 (4,87); 1,0491 (7,06); 1,0368 (4,14); 1,0292 (2,97); 1,0166 (1,38); 0,8947 (0,36); 0,8765 (0,85); 0,8584 (1,12); 0,8369 (0,95); 0,8247 (0,52); 0,8188 (0,78);  I, 0569 (4,87); 1.0491 (7.06); 1.0368 (4.14); 1.0292 (2.97); 1.0166 (1.38); 0.8947 (0.36); 0.8765 (0.85); 0.8584 (1.12); 0.8369 (0.95); 0.8247 (0.52); 0.8188 (0.78);
0,8055 (0,43); 0,799 (0,4); 0,5361 (0,32); 0,517 (1,99); 0,5108 (3,12); 0,5067 (3,04); 0,4974 (5,96); 0,4925 (5,12); 0,4851 (5,99); 0,4763 (8,98); 0,464 (3,74); 0,4555 (3,73); 0,4053 (2,75); 0,3967 (3,63); 0,393 (4,65); 0,3845 (8,14); 0,3766 (4,28); 0,372 (6,87); 0,3646 (10,55); 0,3603 (6,35); 0,3476 (7,58); 0,3445 (7,74); 0,3409 (8,81); 0,328 (8,81); 0,3184 (7,94); 0,306 (4,02); 0,2973 (5,69); 0,2882 (5,3); 0,2838 (6,47); 0,2754 (8,57); 0,2623 (7,68); 0,2548 (3,69); 0,2486 (2,82); 0,2393 (0,74); 0,2288 (0,69); 0.8055 (0.43); 0.799 (0.4); 0.5361 (0.32); 0.517 (1.99); 0.5108 (3.12); 0.5067 (3.04); 0.4974 (5.96); 0.4925 (5.12); 0.4851 (5.99); 0.4763 (8.98); 0.464 (3.74); 0.4555 (3.73); 0.4053 (2.75); 0.3967 (3.63); 0.393 (4.65); 0.3845 (8.14); 0.3766 (4.28); 0.372 (6.87); 0.3664 (10.55); 0.3603 (6.35); 0.3476 (7.58); 0.3445 (7.74); 0.3409 (8.81); 0.328 (8.81); 0.3184 (7.94); 0.306 (4.02); 0.2973 (5.69); 0.2882 (5.3); 0.2838 (6.47); 0.2754 (8.57); 0.2623 (7.68); 0.2548 (3.69); 0.2486 (2.82); 0.2393 (0.74); 0.2288 (0.69);
0,2162 (0,66); 0,2039 (1,2); 0,1987 (1,5); 0,1947 (1,37); 0,1862 (1,55); 0,1826 (1,19); 0,17 (0,55); 0,1594 (0,37); 0,1468 (0,37); 0,0081 (1,88); 0.2162 (0.66); 0.2039 (1.2); 0.1987 (1.5); 0.1947 (1.37); 0.1862 (1.55); 0.1826 (1.19); 0.17 (0.55); 0.1594 (0.37); 0.1468 (0.37); 0.0081 (1.88);
Verbindung Nr.219, Lösungsmittel: [DMSO],: 400 MHz Compound No.219, solvent: [DMSO] ,: 400 MHz
II, 6353 (2,84); 7,6671 (5,21); 7,2155 (11,77); 3,3635 (53,54); 3,3401 (25,69); 3,1649 (5,72); 2,6746 (3,58); 2,67 (5,03); 2,6653 (3,65); 2,5381 (1 ,99); 2,5333 (4,78); 2,5235 II, 6353 (2.84); 7.6671 (5.21); 7.2155 (11.77); 3.3635 (53.54); 3,3401 (25,69); 3.1649 (5.72); 2.6746 (3.58); 2.67 (5.03); 2,6653 (3.65); 2.5381 (1, 99); 2.5333 (4.78); 2.5235
(15,86); 2,5188 (21,26); 2,5101 (305,53); 2,5055 (667,42); 2,5009 (930,02); 2,4963 (645,02); 2,4917 (282,72); 2,4663 (2,81); 2,4499 (3,19); 2,3323 (4,72); 2,3275 (6,07); 2,323 (4,74); 2,2028 (16); 2,0732 (1,9); 0,008 (7,46); -0,0002 (299,19); -0,0086 (8,02); Verbindung Nr.204, Lösungsmittel: [DMSO], 400 MHz (15.86); 2,5188 (21,26); 2,5101 (305.53); 2,5055 (667.42); 2,5009 (930.02); 2.4963 (645.02); 2,4917 (282,72); 2.4663 (2.81); 2.4499 (3.19); 2.3323 (4.72); 2.3275 (6.07); 2,323 (4,74); 2,2028 (16); 2.0732 (1.9); 0.008 (7.46); -0,0002 (299,19); -0.0086 (8.02); Compound No. 204, solvent: [DMSO], 400 MHz
11 ,909 (1 ,22); 7,67 (2,17); 7,6179 (1 ,06); 5,2481 (1,12); 5,2371 (1 ); 4,2026 (1 ,47); 4,2004 (1,42); 4,1848 (3,41); 4,1827 (3,4); 4,1669 (3,69); 4,165 (3,39); 4,1537 (0,5); 4,149 (1,32); 4,1359 (1,13); 4,1181 (1,16); 4,1076 (1,15); 4,0898 (1,07); 3,3298 (34,63); 3,2933 (0,74); 3,2784 (0,55); 3,26 (0,81); 3,1656 (1,08); 3,1566 (0,56); 3,1316 (0,77); 3,1246 (0,75); 2,6747 (0,67); 2,6701 (0,92); 2,6656 (0,66); 2,5452 (0,61 );  11, 909 (1, 22); 7:67 (2:17); 7,6179 (1, 06); 5.2481 (1.12); 5,2371 (1); 4,2026 (1,47); 4,2004 (1.42); 4,1848 (3.41); 4,1827 (3,4); 4, 1669 (3.69); 4,165 (3.39); 4.1537 (0.5); 4.149 (1.32); 4.1359 (1.13); 4.1181 (1.16); 4,1076 (1.15); 4.0898 (1.07); 3,3298 (34,63); 3.2933 (0.74); 3,2784 (0.55); 3.26 (0.81); 3.1656 (1.08); 3.1566 (0.56); 3.1316 (0.77); 3.1246 (0.75); 2.6747 (0.67); 2,6701 (0.92); 2.6656 (0.66); 2.5452 (0.61);
2,5404 (1,07); 2,5379 (0,97); 2,5328 (1,3); 2,5236 (3,66); 2,5189 (4,88); 2,5103 (54,44); 2,5057 (116,52); 2,501 (160,76); 2,4964 (110,01); 2,4918 (47,65); 2,455 (0,68); 2,4503 (1,26); 2,4457 (1,18); 2,4412 (0,84); 2,3543 (4,72); 2,349 (4,72); 2,3324 (1,21); 2,3277 (2,01); 2,3225 (2,61); 2,3159 (2,37); 2,1892 (0,67); 2,1529 (0,64); 2.5404 (1.07); 2.5379 (0.97); 2.5328 (1.3); 2.5236 (3.66); 2.5189 (4.88); 2,5103 (54.44); 2,5057 (116,52); 2,501 (160.76); 2.4964 (110.01); 2,4918 (47,65); 2,455 (0.68); 2,4503 (1.26); 2.4457 (1.18); 2.4412 (0.84); 2.3543 (4.72); 2,349 (4.72); 2.3324 (1.21); 2.3277 (2.01); 2.3225 (2.61); 2.3159 (2.37); 2,1892 (0.67); 2.1529 (0.64);
2,0734 (1 ,27); 1 ,7002 (1 ,5); 1 ,6857 (1 ,43); 1 ,6741 (1 ,68); 1 ,6599 (1 ,46); 1 ,6413 (0,63); 1,626 (0,5); 1,5372 (0,74); 1,3954 (0,55); 1,3542 (0,54); 1,3264 (0,51); 1,2708 (0,64); 1 ,253 (7,13); 1 ,2352 (16); 1 ,2174 (6,92); 1,19 (3,24); 1 ,1722 (6,98); 1 ,1545 (3,12); 0,008 (1,37); 0,0057 (0,51); 0,0048 (0,62); 0,004 (0,81); -0,0002 (42,99); -0,0085 (1,07); Verbindung Nr. 220, Lösungsmittel: [DMSO], 400 MHz 2,0734 (1, 27); 1, 7002 (1, 5); 1, 6857 (1, 43); 1, 6741 (1, 68); 1, 6599 (1, 46); 1, 6413 (0.63); 1,626 (0.5); 1.5372 (0.74); 1.3954 (0.55); 1.3542 (0.54); 1.3264 (0.51); 1.2708 (0.64); 1, 253 (7:13); 1, 2352 (16); 1, 2174 (6.92); 1,19 (3,24); 1, 1722 (6.98); 1, 1545 (3.12); 0.008 (1.37); 0.0057 (0.51); 0.0048 (0.62); 0.004 (0.81); -0,0002 (42.99); -0.0085 (1.07); Compound No. 220, solvent: [DMSO], 400 MHz
1 1 ,9778 (0,5); 7,7003 (2,04); 7,6231 (1 ,06); 4,2494 (6,39); 4,0227 (2,92); 3,6922 (16); 3,6812 (0,54); 3,6046 (8,06); 3,3596 (1 ,18); 3,0045 (7,15); 2,8773 (15,21 ); 2,5244 (0,82); 2,5196 (1 ,17); 2,51 1 (17,21 ); 2,5064 (37,74); 2,5018 (52,89); 2,4971 (36,74); 2,4926 (16,22); 2,3583 (3,5); 2,3529 (3,67); 2,3189 (1 ,86); 2,3133 (1 ,81 ); -0,0002 (2,24);  1 1, 9778 (0.5); 7,7003 (2.04); 7, 6231 (1, 06); 4,2494 (6,39); 4.0227 (2.92); 3,6922 (16); 3.6812 (0.54); 3.6046 (8.06); 3.3596 (1, 18); 3.0045 (7.15); 2,8773 (15,21); 2.5244 (0.82); 2,5196 (1, 17); 2.51 1 (17.21); 2.5064 (37.74); 2.5018 (52.89); 2.4971 (36.74); 2,4926 (16,22); 2.3583 (3.5); 2.3529 (3.67); 2.3189 (1, 86); 2,3133 (1, 81); -0,0002 (2.24);
Verbindung Nr. 329, Lösungsmittel: [DMSO], 400 MHz Compound No. 329, solvent: [DMSO], 400 MHz
1 1 ,5835 (4,4); 7,6627 (6,33); 7,4239 (1 ); 7,2468 (9,63); 7,2188 (14,78); 7,1689 (4,88); 3,3446 (24,36); 3,3242 (138,5); 3,3014 (8,54); 3,2652 (0,98); 3,2619 (1 ,01 ); 3,2396 (0,75); 3,177 (0,94); 2,6767 (0,6); 2,6721 (0,84); 2,6674 (0,6); 2,5423 (0,88); 2,5374 (0,57); 2,5326 (0,56); 2,5255 (2,03); 2,5208 (3,18); 2,5122 (45,06); 2,5076 (98,48); 2,503 (137,52); 2,4983 (96,02); 2,4938 (42,71 ); 2,3735 (0,87); 2,3391 (0,9); 2,3344 (1 ,22); 2,3298 (1 ,45); 2,3251 (1 ,2); 2,2153 (16); 2,0739 (0,77); 0,008 (1 ,42); 0,0056 (0,56); -0,0002 (45,6); -0,0085 (1 ,19); 1, 5835 (4,4); 7,6627 (6,33); 7,4239 (1); 7.2468 (9.63); 7.2188 (14.78); 7.1689 (4.88); 3,3446 (24,36); 3,3242 (138.5); 3.3014 (8.54); 3.2652 (0.98); 3,2619 (1, 01); 3,2396 (0.75); 3.177 (0.94); 2.6767 (0.6); 2.6721 (0.84); 2.6674 (0.6); 2.5423 (0.88); 2.5374 (0.57); 2.5326 (0.56); 2.5255 (2.03); 2,5208 (3,18); 2.5122 (45.06); 2.5076 (98.48); 2,503 (137.52); 2.4983 (96.02); 2,4938 (42.71); 2.3735 (0.87); 2.3391 (0.9); 2,3344 (1, 22); 2.3298 (1, 45); 2.3251 (1, 2); 2.2153 (16); 2.0739 (0.77); 0.008 (1, 42); 0.0056 (0.56); -0.0002 (45.6); -0.0085 (1, 19);
Verbindung Nr. 330, Lösungsmittel: [DMSO], 400 MHz Compound No. 330, solvent: [DMSO], 400 MHz
1 1 ,912 (0,51 ); 8,1919 (1 ,03); 7,7006 (2,31 ); 7,6204 (1 ,16); 4,2524 (6,67); 4,0242 (2,91 ); 3,6932 (16); 3,6022 (7,85); 3,5061 (0,73); 3,4438 (0,79); 3,0071 (6,81 ); 2,8778 (15,08); 2,5245 (0,76); 2,5198 (1 ,16); 2,51 1 1 (18,17); 2,5066 (40,02); 2,5019 (56,21 ); 2,4973 (39,58); 2,4927 (17,85); 2,3886 (1 ,23); 2,3805 (3,81 ); 2,3725 (4,77); 2,364 (2,31 ); 2,3404 (1 ,14); 2,3321 (2,14); 2,3237 (1 ,3); -0,0002 (15,03); Verbindung Nr. 2252, Lösungsmittel: [DMSO], 400 MHz  1 1, 912 (0.51); 8, 1919 (1, 03); 7,7006 (2.31); 7,6204 (1, 16); 4,2524 (6,67); 4.0242 (2.91); 3,6932 (16); 3,6022 (7,85); 3.5061 (0.73); 3.4438 (0.79); 3.0071 (6.81); 2.8778 (15.08); 2.5245 (0.76); 2,5198 (1, 16); 2.51 1 1 (18.17); 2.5066 (40.02); 2.5019 (56.21); 2,4973 (39.58); 2,4927 (17,85); 2,3886 (1, 23); 2.3805 (3.81); 2.3725 (4.77); 2,364 (2.31); 2,3404 (1, 14); 2.3321 (2.14); 2,3237 (1, 3); -0,0002 (15.03); Compound No. 2252, solvent: [DMSO], 400 MHz
7,682 (3,24); 7,5992 (1 ,9); 4,148 (7,07); 3,91 15 (3,67); 3,3215 (108,24); 2,9899 (8,76); 2,8594 (16); 2,6705 (0,64); 2,5407 (0,65); 2,524 (1 ,35); 2,5193 (1 ,98); 2,5106 (33,34); 2,506 (73,45); 2,5014 (102,9); 2,4968 (72,2); 2,4922 (32,23); 2,3787 (2,44); 2,3701 (4,84); 2,3612 (2,64); 2,3327 (1 ,9); 2,3237 (3,29); 2,3148 (1 ,54); -0,0002 (10,57);  7,682 (3,24); 7.5992 (1, 9); 4,148 (7.07); 3.91 15 (3.67); 3,3215 (108,24); 2.9899 (8.76); 2,8594 (16); 2.6705 (0.64); 2.5407 (0.65); 2,524 (1, 35); 2,5193 (1, 98); 2,5106 (33,34); 2,506 (73.45); 2.5014 (102.9); 2.4968 (72.2); 2,4922 (32,23); 2.3787 (2.44); 2.3701 (4.84); 2.3612 (2.64); 2,3327 (1, 9); 2,3237 (3,29); 2,3148 (1,54); -0.0002 (10.57);
Verbindung Nr. 2, Lösungsmittel [DMSO], 400 MHz Compound No. 2, solvent [DMSO], 400 MHz
9,738(0,5); 8,107(3,3); 3,446(0,4); 3,391 (50,0); 3,332(0,8); 3,314(1 ,4); 3,299(1 ,5); 3,295(1 ,5); 3,281 (1 ,4); 3,263(0,4); 3,176(0,8); 2,517(9,4); 2,512(20,5); 2,508(29,0); 2,503(20,6); 2,499(9,3); 2,248(7,9); 2,054(8,1); 1,127(3,0); 1,109(6,4); 1,091(2,9); 0,006(0,5) 9.738 (0.5); 8,107 (3.3); 3,446 (0.4); 3,391 (50.0); 3,332 (0.8); 3,314 (1, 4); 3,299 (1, 5); 3,295 (1, 5); 3,281 (1, 4); 3,263 (0.4); 3,176 (0.8); 2,517 (9.4); 2,512 (20.5); 2,508 (29.0); 2,503 (20.6); 2,499 (9.3); 2,248 (7.9); 2.054 (8.1); 1,127 (3.0); 1,109 (6.4); 1,091 (2.9); 0.006 (0.5)
Verbindung Nr.23, Lösungsmittel [CDCI3], 400 MHz Compound No.23, solvent [CDCl3], 400 MHz
9,403(1 ,1 ); 8,426(7,8); 7,2642(16,9); 7,2635(16,2); 3,475(2,1 ); 3,457(3,3); 3,443(3,1 ); 3,439(3,3); 3,425(2,2); 2,351(21,4); 2,148(21,5); 2,108(50,0); 1,722(0,7); 1,706(1,5); 1,689(1,9); 1,672(1,7); 1,655(1,0); 1,639(0,3); 1,522(2,4); 1,504(5,0); 1,486(4,9); 9,403 (1, 1); 8,426 (7.8); 7.2642 (16.9); 7.2635 (16.2); 3,475 (2.1); 3,457 (3.3); 3,443 (3.1); 3,439 (3.3); 3,425 (2.2); 2,351 (21.4); 2,148 (21.5); 2,108 (50.0); 1,722 (0.7); 1,706 (1.5); 1,689 (1.9); 1,672 (1.7); 1,655 (1.0); 1,639 (0.3); 1,522 (2.4); 1,504 (5.0); 1,486 (4.9);
1,468(1,9); 0,979(0,6); 0,962(0,7); 0,949(30,0); 0,932(28,7); 0,922(1,7); 0,906(1,2); 0,000(4,3) 1.468 (1.9); 0.979 (0.6); 0.962 (0.7); 0.949 (30.0); 0.932 (28.7); 0.922 (1.7); 0.906 (1.2); 0.000 (4.3)
Verbindung Nr.59, Lösungsmittel [DMSO], 400 MHz Compound No. 59, solvent [DMSO], 400 MHz
12,414(0,5); 10,063(0,7); 8,104(3,5); 7,670(1,1); 7,667(1,1); 4,115(3,4); 4,100(3,4); 3,643(16,0); 3,324(11,7); 2,523(1,0); 2,519(1,5); 2,510(21,2); 2,506(45,0); 2,501(61,5); 2,496(42,8); 2,492(19,2); 2,259(7,7); 2,055(8,4); 0,008(1,2); 0,000(38,9); -0,009(1,1)  12.414 (0.5); 10,063 (0.7); 8,104 (3.5); 7,670 (1.1); 7,667 (1.1); 4,115 (3.4); 4,100 (3.4); 3,643 (16.0); 3,324 (11.7); 2,523 (1.0); 2,519 (1.5); 2,510 (21.2); 2,506 (45.0); 2,501 (61.5); 2,496 (42.8); 2,492 (19.2); 2,259 (7.7); 2,055 (8.4); 0.008 (1.2); 0,000 (38.9); -0.009 (1.1)
Verbindung Nr.610, Lösungsmittel [DMSO], 400 MHz Compound No.610, solvent [DMSO], 400 MHz
8,339(3,4); 8,221 (1 ,6); 4,137(3,8); 4,123(3,8); 3,664(16,0); 2,711 (1 ,9); 2,693(1 ,9); 2,672(1,0); 2,506(58,3); 2,502(75,3); 2,497(55,0); 2,329(0,5); 1,189(2,8); 1,182(2,0); 8,339 (3.4); 8,221 (1, 6); 4,137 (3.8); 4,123 (3.8); 3,664 (16.0); 2,711 (1, 9); 2,693 (1, 9); 2,672 (1.0); 2,506 (58.3); 2,502 (75.3); 2,497 (55.0); 2,329 (0.5); 1,189 (2.8); 1,182 (2.0);
I, 170(5,9); 1,163(3,8); 1,151(2,9); 1,144(1,7); 0,000(20,5) I, 170 (5.9); 1,163 (3.8); 1,151 (2.9); 1,144 (1.7); 0.000 (20.5)
Verbindung Nr.645, Lösungsmittel [DMSO], 400 MHz Compound No.645, solvent [DMSO], 400 MHz
II, 950(1,0); 7,696(5,8); 7,639(2,9); 5,255(2,5); 5,246(2,4); 4,466(0,9); 4,433(0,9); 4,204(3,0); 4,188(5,6); 4,170(5,3); 4,152(2,5); 4,133(1,9); 4,116(2,2); 4,112(2,2);  II, 950 (1.0); 7,696 (5.8); 7,639 (2.9); 5,255 (2.5); 5,246 (2.4); 4,466 (0.9); 4,433 (0.9); 4,204 (3.0); 4,188 (5.6); 4,170 (5.3); 4,152 (2.5); 4,133 (1.9); 4,116 (2.2); 4,112 (2.2);
4,095(1,8); 4,077(0,6); 4,068(0,6); 3,546(2,9); 3,282(1,1); 3,250(1,8); 3,162(1,1); 4,095 (1.8); 4,077 (0.6); 4,068 (0.6); 3,546 (2.9); 3,282 (1.1); 3,250 (1.8); 3,162 (1.1);
3,131(1,6); 3,104(0,8); 2,765(0,7); 2,706(3,4); 2,688(3,9); 2,672(3,2); 2,508(52,1); 2,503(67,2); 2,499(53,7); 2,191(1,4); 2,157(1,5); 2,087(0,6); 2,061(0,9); 2,029(0,9); 1,669(4,1); 1,571(1,1); 1,539(1,7); 1,433(1,1); 1,399(1,3); 1,359(1,4); 1,331(1,3); 3,131 (1.6); 3,104 (0.8); 2,765 (0.7); 2,706 (3.4); 2,688 (3.9); 2,672 (3.2); 2,508 (52.1) 2,503 (67.2); 2,499 (53.7); 2,191 (1.4); 2.157 (1.5); 2,087 (0.6); 2,061 (0.9); 2,029 (0.9); 1.669 (4.1); 1,571 (1.1); 1.539 (1.7); 1,433 (1.1); 1,399 (1.3); 1,359 (1.4); 1,331 (1.3);
1,275(1,4); 1,256(7,8); 1,239(16,0); 1,221(7,5); 1,192(5,1); 1,174(11,6); 1,159(13,3); 1,146(6,1); 1,141(7,1); 1,128(6,9); 1,109(3,3); 0,000(9,2) 1.275 (1.4); 1,256 (7.8); 1,239 (16.0); 1,221 (7.5); 1.192 (5.1); 1.174 (11.6); 1,159 (13.3); 1,146 (6.1); 1,141 (7.1); 1,128 (6.9); 1,109 (3.3); 0.000 (9.2)
Verbindung Nr.719, Lösungsmittel [DMSO], 400 MHz Compound No. 719, solvent [DMSO], 400 MHz
13,007(1,0); 8,339(3,8); 4,137(3,7); 4,122(3,9); 3,666(16,0); 3,317(13,7); 2,728(1,4); 2,709(1,5); 2,506(43,2); 2,502(58,0); 2,497(47,2); 1,197(2,7); 1,178(5,7); 1,159(2,7); 0,000(17,2) Verbindung Nr.754, Lösungsmittel [DMSO], 400 MHz 13.007 (1.0); 8,339 (3.8); 4,137 (3.7); 4,122 (3.9); 3,666 (16.0); 3,317 (13.7); 2,728 (1.4); 2,709 (1.5); 2,506 (43.2); 2,502 (58.0); 2,497 (47.2); 1,197 (2.7); 1,178 (5.7); 1,159 (2.7); 0.000 (17.2) Compound No.754, solvent [DMSO], 400 MHz
11,863(5,0); 7,702(5,8); 7,640(2,8); 5,253(2,8); 4,462(1,0); 4,428(1,0); 4,203(2,8); 4,186(6,7); 4,169(5,7); 4,151(2,6); 4,133(2,1); 4,115(2,8); 4,099(2,0); 3,336(75,3); 3,271 (1 ,4); 3,235(2,1 ); 3,169(1 ,5); 3,136(1 ,8); 3,109(0,8); 2,771 (0,9); 2,713(3,2);  11.863 (5.0); 7,702 (5.8); 7,640 (2.8); 5,253 (2.8); 4,462 (1.0); 4,428 (1.0); 4,203 (2.8); 4,186 (6.7); 4,169 (5.7); 4,151 (2.6); 4,133 (2.1); 4,115 (2.8); 4,099 (2.0); 3,336 (75.3); 3,271 (1, 4); 3,235 (2,1); 3,169 (1, 5); 3,136 (1, 8); 3,109 (0.8); 2,771 (0.9); 2,713 (3.2);
2,697(3,8); 2,677(3,5); 2,502(164,0); 2,498(137,5); 2,448(1,0); 2,329(1,0); 2,189(1,6); 2,161(1,7); 2,071(0,9); 2,034(0,9); 1,672(4,2); 1,583(1,2); 1,550(1,9); 1,431(1,3);  2,697 (3.8); 2,677 (3.5); 2.502 (164.0); 2.498 (137.5); 2,448 (1.0); 2,329 (1.0); 2,189 (1.6); 2,161 (1.7); 2,071 (0.9); 2,034 (0.9); 1,672 (4.2); 1,583 (1.2); 1,550 (1.9); 1,431 (1.3);
1,400(1,6); 1,358(1,6); 1,336(1,4); 1,310(1,1); 1,257(8,0); 1,239(16,0); 1,221(7,6);1,400 (1.6); 1.358 (1.6); 1.336 (1.4); 1,310 (1.1); 1.257 (8.0); 1,239 (16.0); 1,221 (7.6);
I, 188(4,7); 1,180(6,7); 1,171(10,1); 1,162(12,9); 1,153(7,1); 1,143(8,5); 1,127(6,6); 1,109(3,2); 0,000(33,8) I, 188 (4,7); 1,180 (6.7); 1,171 (10.1); 1,162 (12.9); 1,153 (7.1); 1.143 (8.5); 1,127 (6.6); 1,109 (3.2); 0.000 (33.8)
Verbindung Nr.770, Lösungsmittel [DMSO], 400 MHz Compound No.770, solvent [DMSO], 400 MHz
II, 919(0,7); 7,733(2,9); 7,634(1,6); 4,257(6,8); 4,016(3,4); 3,696(16,0); 3,680(0,6); 3,599(9,1); 3,407(3,9); 3,017(8,1); 2,878(14,9); 2,719(1,0); 2,701(1,2); 2,680(0,8); 2,675(1 ,0); 2,671 (0,8); 2,666(0,6); 2,661 (0,6); 2,656(0,6); 2,524(0,7); 2,520(1 ,0);  II, 919 (0.7); 7,733 (2.9); 7,634 (1.6); 4,257 (6.8); 4,016 (3.4); 3.696 (16.0); 3,680 (0.6); 3,599 (9.1); 3,407 (3.9); 3,017 (8.1); 2,878 (14.9); 2,719 (1.0); 2,701 (1.2); 2,680 (0.8); 2,675 (1, 0); 2,671 (0.8); 2,666 (0.6); 2,661 (0.6); 2,656 (0.6); 2,524 (0.7); 2,520 (1, 0);
2,511(12,9); 2,507(27,9); 2,502(38,9); 2,497(27,0); 2,493(12,0); 1,185(2,5); 1,166(5,5); 1,147(2,5); 1,139(1,6); 1,121(3,2); 1,102(1,4); 0,000(7,0)  2,511 (12.9); 2,507 (27.9); 2,502 (38.9); 2,497 (27.0); 2,493 (12.0); 1,185 (2.5); 1,166 (5.5); 1,147 (2.5); 1,139 (1.6); 1,121 (3.2); 1.102 (1.4); 0.000 (7.0)
Verbindung Nr.1049, Lösungsmittel [DMSO], 400 MHz Compound No. 1049, solvent [DMSO], 400 MHz
8,319(2,6); 4,136(3,0); 4,121(3,0); 3,663(16,0); 3,316(45,4); 2,675(1,0); 2,670(1,2); 2,665(0,9); 2,661(0,8); 2,655(0,9); 2,635(0,5); 2,523(1,7); 2,519(2,5); 2,510(41,4); 2,506(89,0); 2,501(122,2); 2,496(85,2); 2,492(38,3); 2,332(0,5); 2,328(0,7); 2,323(0,5);8,319 (2.6); 4,136 (3.0); 4,121 (3.0); 3,663 (16.0); 3,316 (45.4); 2,675 (1.0); 2,670 (1.2); 2,665 (0.9); 2,661 (0.8); 2,655 (0.9); 2,635 (0.5); 2,523 (1.7); 2,519 (2.5); 2,510 (41.4); 2,506 (89.0); 2.501 (122.2); 2,496 (85.2); 2,492 (38.3); 2,332 (0.5); 2,328 (0.7); 2,323 (0.5);
I, 591(0,5); 1,572(0,9); 1,553(0,9); 1,534(0,6); 0,938(2,6); 0,920(5,5); 0,902(2,3); I, 591 (0.5); 1,572 (0.9); 1,553 (0.9); 1,534 (0.6); 0.938 (2.6); 0.920 (5.5); 0.902 (2.3);
0,008(1,0); 0,000(35,7); -0,009(1,1) 0.008 (1.0); 0,000 (35.7); -0.009 (1.1)
Verbindung Nr.1084, Lösungsmittel [DMSO], 400 MHz Compound No. 1084, solvent [DMSO], 400 MHz
II, 952(0,6); 7,671(4,5); 7,606(2,1); 5,253(1,6); 5,242(1,4); 4,463(0,5); 4,429(0,5); 4,205(1,9); 4,202(2,0); 4,197(1,3); 4,187(4,1); 4,185(4,0); 4,169(4,0); 4,167(3,9);  II, 952 (0.6); 7,671 (4.5); 7,606 (2.1); 5,253 (1.6); 5,242 (1.4); 4,463 (0.5); 4,429 (0.5); 4,205 (1.9); 4,202 (2.0); 4,197 (1.3); 4,187 (4.1); 4.185 (4.0); 4,169 (4.0); 4,167 (3.9);
4,150(1,7); 4,141(0,7); 4,133(0,5); 4,123(2,0); 4,106(3,0); 4,088(2,0); 3,561(1,3); 4,150 (1.7); 4,141 (0.7); 4,133 (0.5); 4,123 (2.0); 4,106 (3.0); 4,088 (2.0); 3,561 (1.3);
3,277(0,7); 3,246(1,0); 3,162(0,6); 3,155(0,7); 3,130(1,0); 3,123(1,0); 3,098(0,5); 3,277 (0.7); 3,246 (1.0); 3,162 (0.6); 3,155 (0.7); 3,130 (1.0); 3.123 (1.0); 3,098 (0.5);
2,668(1,5); 2,648(2,3); 2,633(2,1); 2,618(1,6); 2,597(0,9); 2,526(0,5); 2,521(0,8); 2,668 (1.5); 2,648 (2.3); 2,633 (2.1); 2,618 (1.6); 2,597 (0.9); 2,526 (0.5); 2,521 (0.8);
2,512(15,0); 2,508(32,2); 2,503(44,1); 2,499(31,4); 2,494(14,7); 2,190(0,9); 2,159(0,9); 2,087(0,6); 2,075(0,8); 2,033(0,5); 1,697(1,9); 1,686(2,2); 1,679(2,3); 1,667(2,3); 2,512 (15.0); 2,508 (32.2); 2,503 (44.1); 2,499 (31.4); 2,494 (14.7); 2,190 (0.9); 2.159 (0.9); 2,087 (0.6); 2,075 (0.8); 2,033 (0.5); 1,697 (1.9); 1,686 (2.2); 1,679 (2.3); 1.667 (2.3);
1,653(1,3); 1,644(0,8); 1,638(0,7); 1,580(1,6); 1,562(2,7); 1,542(3,4); 1,524(2,4); 1,507(1,2); 1,489(0,5); 1,426(0,7); 1,417(0,6); 1,404(0,6); 1,394(0,9); 1,386(0,7); 1,653 (1.3); 1,644 (0.8); 1,638 (0.7) 1,580 (1.6); 1,562 (2.7); 1.542 (3.4); 1.524 (2.4); 1,507 (1.2); 1,489 (0.5); 1,426 (0.7); 1,417 (0.6); 1,404 (0.6); 1,394 (0.9); 1,386 (0.7);
1,353(0,9); 1,325(0,7); 1,309(0,5); 1,301(0,5); 1,274(0,9); 1,255(7,6); 1,237(16,0); 1,219(7,2); 1,190(4,1); 1,172(8,6); 1,154(4,0); 0,931(5,2); 0,913(11,0); 0,894(5,7); 0,879(6,2); 0,861(2,7); 0,000(13,2) 1,353 (0.9); 1.325 (0.7); 1,309 (0.5); 1,301 (0.5) 1,274 (0.9); 1,255 (7.6); 1,237 (16.0); 1,219 (7.2); 1,190 (4.1); 1,172 (8.6); 1,154 (4.0); 0.931 (5.2); 0.913 (11.0); 0.894 (5.7); 0.879 (6.2); 0.861 (2.7); 0.000 (13.2)
Verbindung Nr.1100, Lösungsmittel [DMSO], 400 MHz Compound No. 1100, solvent [DMSO], 400 MHz
12,009(0,9); 7,699(1,7); 7,596(0,9); 4,250(6,4); 4,018(3,3); 3,693(16,0); 3,592(9,7); 3,309(183,4); 3,007(8,2); 2,872(14,1); 2,674(1,4); 2,670(1,9); 2,665(1,4); 2,660(1,0); 2,650(1,0); 2,631(1,0); 2,608(0,7); 2,523(3,7); 2,518(5,2); 2,510(68,2); 2,505(148,3); 2,500(206,6); 2,496(143,0); 2,491 (63,5); 2,332(0,9); 2,327(1 ,3); 2,323(0,9); 1 ,583(0,6); 1,564(1,1); 1,544(1,3); 1,525(1,2); 1,504(0,8); 0,932(3,0); 0,914(6,4); 0,895(3,8);  12.009 (0.9); 7,699 (1.7); 7,596 (0.9); 4,250 (6.4); 4,018 (3.3); 3,693 (16.0); 3,592 (9.7); 3,309 (183.4); 3,007 (8.2); 2,872 (14.1); 2,674 (1.4); 2,670 (1.9); 2,665 (1.4); 2,660 (1.0); 2,650 (1.0); 2,631 (1.0); 2,608 (0.7); 2,523 (3.7); 2,518 (5.2); 2,510 (68.2); 2.505 (148.3); 2,500 (206.6); 2.496 (143.0); 2,491 (63.5); 2,332 (0.9); 2,327 (1, 3); 2,323 (0.9); 1, 583 (0.6); 1,564 (1.1); 1.544 (1.3); 1.525 (1.2); 1,504 (0.8); 0.932 (3.0); 0.914 (6.4); 0.895 (3.8);
0,875(3,9); 0,857(1,6); 0,008(1,5); 0,000(55,6); -0,006(0,7); -0,007(0,6); -0,009(1,7) 0.875 (3.9); 0.857 (1.6); 0.008 (1.5); 0,000 (55.6); -0.006 (0.7); -0.007 (0.6); -0.009 (1.7)
Verbindung Nr.1159, Lösungsmittel [DMSO], 400 MHz Compound Nr.1159, solvent [DMSO], 400 MHz
13,014(0,9); 8,324(3,9); 4,136(3,7); 4,122(3,9); 3,666(16,0); 3,322(9,5); 2,663(1,7); 2,507(34,2); 2,502(46,4); 2,498(38,2); 2,074(0,8); 1,598(0,8); 1,578(1,5); 1,560(1,6); 1,541(0,9); 0,949(3,0); 0,931(6,2); 0,912(2,9); 0,000(14,8) 13.014 (0.9); 8,324 (3.9); 4,136 (3.7); 4,122 (3.9); 3,666 (16.0); 3,322 (9.5); 2,663 (1.7); 2,507 (34.2); 2,502 (46.4); 2,498 (38.2); 2,074 (0.8); 1,598 (0.8); 1,578 (1.5); 1,560 (1.6); 1.541 (0.9); 0.949 (3.0); 0.931 (6.2); 0.912 (2.9); 0.000 (14.8)
Verbindung Nr.1194, Lösungsmittel [DMSO], 400 MHz Compound No.1194, solvent [DMSO], 400 MHz
11 ,862(3,8); 7,681 (4,9); 7,612(2,3); 5,254(2,2); 5,243(2,0); 4,463(0,8); 4,430(0,8);11, 862 (3,8); 7,681 (4.9); 7.612 (2.3); 5,254 (2.2); 5,243 (2.0); 4,463 (0.8); 4,430 (0.8);
4,202(2,5); 4,188(5,3); 4,185(5,0); 4,170(4,6); 4,152(1,8); 4,141(0,9); 4,123(1,7); 4,202 (2.5); 4,188 (5.3); 4.185 (5.0); 4,170 (4.6); 4,152 (1.8); 4,141 (0.9); 4,123 (1.7);
4,111(1,9); 4,105(1,9); 4,093(1,7); 4,076(0,6); 3,368(12,7); 3,266(1,0); 3,233(1,5); 4,111 (1.9); 4,105 (1.9); 4,093 (1.7); 4,076 (0.6); 3,368 (12.7); 3,266 (1.0); 3,233 (1.5);
3,162(1,1); 3,136(1,4); 3,105(0,7); 2,763(0,6); 2,671(2,3); 2,653(2,9); 2,507(86,9);3.162 (1.1); 3,136 (1.4); 3,105 (0.7); 2,763 (0.6); 2,671 (2.3); 2,653 (2.9); 2,507 (86.9);
2,502(111,7); 2,498(81,3); 2,451(0,5); 2,329(0,7); 2,191(1,3); 2,157(1,3); 2,086(0,7); 2,074(1 ,2); 2,041 (0,7); 1 ,682(3,2); 1 ,581 (2,4); 1 ,561 (3,5); 1 ,542(4,2); 1 ,523(2,6); 2.502 (111.7); 2,498 (81.3); 2,451 (0.5); 2,329 (0.7); 2,191 (1.3); 2.157 (1.3); 2,086 (0.7); 2.074 (1, 2); 2,041 (0.7); 1, 682 (3,2); 1, 581 (2,4); 1, 561 (3,5); 1, 542 (4,2); 1, 523 (2.6);
1,502(1,4); 1,426(1,0); 1,394(1,3); 1,359(1,3); 1,328(1,0); 1,309(0,8); 1,273(1,3);  1.502 (1.4); 1,426 (1.0); 1,394 (1.3); 1,359 (1.3); 1.328 (1.0); 1,309 (0.8); 1,273 (1.3);
I, 256(7,8); 1,238(16,0); 1,220(7,3); 1,187(4,1); 1,169(8,2); 1,151(3,9); 0,937(5,6); 0,919(11,4); 0,901(7,6); 0,884(6,3); 0,865(2,8); 0,000(33,0) Verbindung Nr.1210, Lösungsmittel [DMSO], 400 MHz  I, 256 (7,8); 1.238 (16.0); 1,220 (7.3); 1,187 (4.1); 1,169 (8.2); 1,151 (3.9); 0.937 (5.6); 0.919 (11.4); 0.901 (7.6); 0.884 (6.3); 0.865 (2.8); 0.000 (33.0) Compound No. 1210, solvent [DMSO], 400 MHz
I I , 935(0,8); 11 ,916(1 ,2); 7,712(2,5); 7,605(1 ,5); 4,255(6,7); 4,020(3,4); 3,695(16,0); 3,591(9,5); 3,313(36,7); 3,011(8,4); 2,873(14,4); 2,675(0,8); 2,671(0,9); 2,666(0,9); 2,655(1,0); 2,636(1,0); 2,616(0,7); 2,524(0,8); 2,519(1,2); 2,511(17,0); 2,506(37,2); 2,501(51,9); 2,497(36,2); 2,492(16,2); 2,086(1,3); 2,073(2,7); 1,585(0,6); 1,566(1,1); 1,547(1,2); 1,528(0,9); 1,522(0,9); 1,502(0,8); 0,939(2,9); 0,921(6,2); 0,902(3,5); 0,882(3,8); 0,864(1,6); 0,000(15,6) II, 935 (0.8); 11, 916 (1, 2); 7,712 (2.5); 7.605 (1, 5); 4,255 (6.7); 4,020 (3.4); 3,695 (16.0); 3,591 (9.5); 3,313 (36.7); 3,011 (8.4); 2,873 (14.4); 2,675 (0.8); 2,671 (0.9); 2,666 (0.9); 2,655 (1.0); 2,636 (1.0); 2,616 (0.7); 2,524 (0.8); 2,519 (1.2); 2,511 (17.0); 2,506 (37.2); 2,501 (51.9); 2,497 (36.2); 2,492 (16.2); 2,086 (1.3); 2,073 (2.7); 1.585 (0.6); 1,566 (1.1); 1,547 (1.2); 1,528 (0.9); 1,522 (0.9); 1.502 (0.8); 0.939 (2.9); 0.921 (6.2); 0.902 (3.5); 0.882 (3.8); 0.864 (1.6); 0.000 (15.6)
Verbindung Nr.2379, Lösungsmittel [CDCI3], 400 MHz Compound No. 2379, solvent [CDCl3], 400 MHz
13,084(0,7); 9,304(1 ,5); 8,663(15,1 ); 8,643(0,6); 7,263(32,2); 3,518(1 ,5); 3,504(1 ,9); 3,500(5,1); 3,486(5,3); 3,482(5,4); 3,468(5,2); 3,464(2,0); 3,450(1,6); 2,621(1,6); 2,528(44,8); 1,671(0,6); 1,428(0,9); 1,260(12,5); 1,242(26,5); 1,224(12,1); 0,008(0,5); 0,000(18,4); -0,002(7,2) Verbindung Nr.2380, Lösungsmittel [CDCI3], 400 MHz 13,084 (0.7); 9,304 (1, 5); 8,663 (15,1); 8,643 (0.6); 7,263 (32.2); 3.518 (1, 5); 3,504 (1, 9); 3,500 (5.1); 3,486 (5.3); 3,482 (5.4); 3,468 (5.2); 3,464 (2.0); 3,450 (1.6); 2,621 (1.6); 2,528 (44.8); 1,671 (0.6); 1,428 (0.9); 1,260 (12.5); 1,242 (26.5); 1,224 (12.1); 0.008 (0.5); 0,000 (18.4); -0.002 (7.2) Compound No. 2380, solvent [CDCl3], 400 MHz
13,239(1,2); 9,364(1,8); 8,669(17,1); 7,264(22,9); 7,263(27,5); 7,260(0,7); 7,259(0,5); 3,451(3,6); 3,434(7,8); 3,420(7,9); 3,402(3,8); 2,525(48,4); 1,676(0,9); 1,658(4,1); 1,640(8,4); 1,622(9,7); 1,604(4,6); 1,586(1,0); 1,058(0,5); 1,019(13,5); 1,000(27,3); 0,982(11,9); 0,000(17,2); -0,008(0,5)  13.239 (1.2); 9,364 (1.8); 8,669 (17.1); 7,264 (22.9); 7,263 (27.5); 7,260 (0.7); 7,259 (0.5); 3,451 (3.6); 3,434 (7.8); 3,420 (7.9); 3,402 (3.8); 2.525 (48.4); 1.676 (0.9); 1,658 (4.1); 1,640 (8.4); 1,622 (9.7); 1,604 (4.6); 1.586 (1.0); 1,058 (0.5); 1,019 (13.5); 1,000 (27.3); 0.982 (11.9); 0,000 (17.2); -0.008 (0.5)
Verbindung Nr.2400, Lösungsmittel [CDCI3], 400 MHz Compound No.2400, solvent [CDCl3], 400 MHz
12,980(0,5); 9,305(1,9); 8,669(1,8); 7,260(4,8); 3,502(0,5); 3,482(1,4); 3,462(1,4); 3,422(0,5); 2,501(5,7); 1,749(0,2); 1,719(0,5); 1,699(0,7); 1,879(0,5); 1,659(0,2); 12.980 (0.5); 9,305 (1.9); 8,669 (1.8); 7,260 (4.8); 3,502 (0.5); 3,482 (1.4); 3,462 (1.4); 3,422 (0.5); 2,501 (5.7); 1,749 (0.2); 1,719 (0.5); 1,699 (0.7); 1,879 (0.5); 1,659 (0.2);
I, 585(4,2); 1,522(0,5); 1,502(1,4); 1,482(1,4); 1,462(0,5); 0,979(6,3); 0,921(6,3); - 0,002(2,5) I, 585 (4,2); 1,522 (0.5); 1.502 (1.4); 1,482 (1.4); 1.462 (0.5); 0.979 (6.3); 0.921 (6.3); - 0,002 (2,5)
Verbindung Nr.2423, Lösungsmittel [DMSO], 400 MHz Compound No. 2423, solvent [DMSO], 400 MHz
12,873(1,0); 9,650(1,0); 8,252(7,7); 3,482(0,4); 3,473(0,7); 3,464(2,3); 3,453(3,1); 3,450(2,7); 3,441(7,5); 3,431(4,1); 3,419(0,9); 3,413(0,5); 3,317(45,4); 3,305(1,8); 3,268(30,6); 2,525(0,4); 2,511 (8,9); 2,507(19,4); 2,502(27,3); 2,498(19,4); 2,493(8,7); 2,371(19,7); 2,074(0,3); 0,000(1,5)  12.873 (1.0); 9,650 (1.0); 8.252 (7.7); 3,482 (0.4); 3,473 (0.7); 3,464 (2.3); 3,453 (3.1); 3,450 (2.7); 3,441 (7.5); 3,431 (4.1); 3,419 (0.9); 3,413 (0.5); 3,317 (45.4); 3,305 (1.8); 3,268 (30.6); 2,525 (0.4); 2,511 (8.9); 2,507 (19.4); 2,502 (27.3); 2,498 (19.4); 2,493 (8.7); 2,371 (19.7); 2,074 (0.3); 0.000 (1.5)
Verbindung Nr.3915, Lösungsmittel [DMSO], 400 MHz Compound No. 3915, solvent [DMSO], 400 MHz
II, 838(1,6); 7,225(7,6); 3,383(1,0); 3,365(2,9); 3,347(3,3); 3,315(23,4); 3,176(1,0); 3,170(0,9); 3,158(2,8); 3,140(2,8); 3,123(1,0); 2,511(8,4); 2,506(17,6); 2,502(24,2); II, 838 (1.6); 7,225 (7.6); 3,383 (1.0); 3,365 (2.9); 3,347 (3.3); 3,315 (23.4); 3,176 (1.0); 3,170 (0.9); 3,158 (2.8); 3,140 (2.8); 3.123 (1.0); 2,511 (8.4); 2,506 (17.6); 2,502 (24.2);
2,497(18,0); 2,493(9,0); 2,338(0,4); 2,149(16,8); 2,108(0,4); 1,964(17,1); 1,908(50,0); 1,103(3,1); 1,086(6,6); 1,068(3,2); 1,034(3,2); 1,016(6,6); 0,999(3,0); 0,000(4,6) Verbindung Nr.3917, Lösungsmittel [DMSO], 400 MHz 2,497 (18.0); 2,493 (9.0); 2,338 (0.4); 2,149 (16.8); 2,108 (0.4); 1,964 (17.1); 1,908 (50.0); 1,103 (3.1); 1,086 (6.6); 1,068 (3.2); 1,034 (3.2); 1.016 (6.6); 0.999 (3.0); 0.000 (4.6) Compound No. 3917, solvent [DMSO], 400 MHz
8,395(0,6); 7,702(0,7); 7,699(0,7); 7,626(0,7); 7,316(2,6); 7,299(1,8); 7,208(1,6); 4,252(8,8); 4,152(3,3); 4,075(2,8); 3,760(2,2); 3,701(16,0); 3,669(10,7); 3,655(1,6); 3,580(9,6); 3,168(0,8); 3,098(7,2); 2,943(6,4); 2,914(9,8); 2,674(0,6); 2,670(0,9); 2,665(0,6); 2,523(2,5); 2,518(3,8); 2,510(50,5); 2,505(109,6); 2,501 (152,9);  8,395 (0.6); 7,702 (0.7); 7,699 (0.7); 7,626 (0.7); 7,316 (2.6); 7,299 (1.8); 7,208 (1.6); 4,252 (8.8); 4,152 (3.3); 4.075 (2.8); 3,760 (2.2); 3,701 (16.0); 3,669 (10.7); 3,655 (1.6); 3,580 (9.6); 3,168 (0.8); 3,098 (7.2); 2,943 (6.4); 2,914 (9.8); 2,674 (0.6); 2,670 (0.9); 2,665 (0.6); 2,523 (2.5); 2,518 (3.8); 2,510 (50.5); 2.505 (109.6); 2,501 (152.9);
2,496(106,2); 2,491(47,2); 2,332(0,7); 2,327(1,0); 2,323(0,7); 2,173(5,4); 2,159(4,1); 1,987(5,7); 1,958(4,0); 0,008(0,9); 0,000(31,4); -0,009(0,9)  2.496 (106.2); 2,491 (47.2); 2,332 (0.7); 2,327 (1.0); 2,323 (0.7); 2,173 (5.4); 2.159 (4.1); 1,987 (5.7); 1,958 (4.0); 0.008 (0.9); 0,000 (31.4); -0.009 (0.9)
Verbindung Nr.2599, Lösungsmittel [DMSO], 400 MHz Compound No. 2599, solvent [DMSO], 400 MHz
12,289(0,7); 9,730(0,9); 8,132(6,6); 7,918(1,1); 3,710(2,6); 3,431(0,6); 3,317(171,5);12.289 (0.7); 9,730 (0.9); 8,132 (6.6); 7.918 (1.1); 3,710 (2.6); 3,431 (0.6); 3.317 (171.5);
3,309(4,1); 3,295(3,0); 3,291(3,0); 3,277(2,7); 3,259(0,9); 2,670(0,7); 2,524(3,3);3,309 (4.1); 3,295 (3.0); 3,291 (3.0); 3,277 (2.7); 3.259 (0.9); 2,670 (0.7); 2,524 (3.3);
2,519(4,8); 2,510(41,3); 2,506(86,5); 2,501(119,0); 2,497(83,2); 2,492(37,3); 2,519 (4.8); 2,510 (41.3); 2,506 (86.5); 2.501 (119.0); 2,497 (83.2); 2,492 (37.3);
2,448(1,4); 2,429(3,6); 2,410(3,6); 2,391(1,2); 2,370(0,6); 2,333(0,5); 2,328(0,7); 2,448 (1.4); 2,429 (3.6); 2,410 (3.6); 2,391 (1.2); 2,370 (0.6); 2,333 (0.5); 2,328 (0.7);
2,324(0,5); 2,271(16,0); 2,229(1,8); 1,120(5,9); 1,102(13,5); 1,086(6,3); 1,084(7,3); 1 ,068(12,6); 1 ,049(5,5); 1 ,028(0,7); 0,008(1 ,1 ); 0,000(34,3); -0,009(1 ,0) 2,324 (0.5); 2.271 (16.0); 2,229 (1.8); 1,120 (5.9); 1.102 (13.5); 1,086 (6.3); 1,084 (7.3); 1, 068 (12,6); 1, 049 (5.5); 1, 028 (0.7); 0.008 (1, 1); 0,000 (34.3); -0.009 (1, 0)
Verbindung Nr.2620, Lösungsmittel [DMSO], 400 MHz Compound No. 2620, solvent [DMSO], 400 MHz
12,268(0,6); 9,756(0,7); 8,128(4,2); 3,317(71,3); 3,307(1,7); 3,290(1,4); 3,272(0,8); 2,524(2,0); 2,511(20,4); 2,506(42,3); 2,501(58,0); 2,497(40,9); 2,492(18,6);  12.268 (0.6); 9.756 (0.7); 8.128 (4.2); 3,317 (71.3); 3.307 (1.7); 3,290 (1.4); 3,272 (0.8); 2,524 (2.0); 2,511 (20.4); 2,506 (42.3); 2,501 (58.0); 2,497 (40.9); 2,492 (18.6);
2,448(0,8); 2,429(2,2); 2,410(2,2); 2,391 (0,7); 2,272(9,7); 1 ,614(0,6); 1 ,598(0,8); 1,581(0,7); 1,410(1,0); 1,393(1,9); 1,374(1,9); 1,357(0,8); 1,086(3,0); 1,068(7,2); 1,049(2,9); 0,902(16,0); 0,886(15,1); 0,008(0,8); 0,000(21,5); -0,009(0,7) 2,448 (0.8); 2,429 (2.2); 2,410 (2.2); 2.391 (0.7); 2,272 (9.7); 1, 614 (0.6); 1, 598 (0.8); 1,581 (0.7); 1,410 (1.0); 1,393 (1.9); 1,374 (1.9); 1,357 (0.8); 1,086 (3.0); 1,068 (7.2); 1,049 (2.9); 0.902 (16.0); 0.886 (15.1); 0.008 (0.8); 0,000 (21.5); -0.009 (0.7)
Verbindung Nr.2643, Lösungsmittel [DMSO], 400 MHz Compound No. 2643, solvent [DMSO], 400 MHz
12,279(0,9); 9,849(1 ,0); 9,836(0,5); 8,137(6,5); 3,463(0,6); 3,453(2,0); 3,442(2,8); 3,438(2,8); 3,431(6,4); 3,423(3,5); 3,410(0,8); 3,368(0,6); 3,350(0,5); 3,318(138,4); 3,269(1,0); 3,265(35,4); 2,524(2,1); 2,519(3,1); 2,511(25,1); 2,506(51,3); 2,501(69,8); 2,497(49,0); 2,492(21,9); 2,450(1,1); 2,431(3,4); 2,412(3,5); 2,393(1,2); 2,276(16,0);12.279 (0.9); 9,849 (1, 0); 9.836 (0.5); 8.137 (6.5); 3,463 (0.6); 3,453 (2.0); 3,442 (2.8); 3,438 (2.8); 3,431 (6.4); 3,423 (3.5); 3,410 (0.8); 3,368 (0.6); 3,350 (0.5); 3.318 (138.4); 3,269 (1.0); 3,265 (35.4); 2,524 (2.1); 2,519 (3.1); 2,511 (25.1); 2,506 (51.3); 2,501 (69.8); 2,497 (49.0); 2,492 (21.9); 2,450 (1.1); 2,431 (3.4); 2.412 (3.5); 2,393 (1.2); 2,276 (16.0);
I, 087(4,9); 1,068(11,8); 1,049(4,7); 0,008(1,2); 0,000(33,4); -0,009(1,0) I, 087 (4,9); 1,068 (11.8); 1,049 (4.7); 0.008 (1.2); 0,000 (33.4); -0.009 (1.0)
Verbindung Nr.2595, Lösungsmittel [DMSO], 400 MHz Compound No. 2595, solvent [DMSO], 400 MHz
II, 681(0,7); 7,242(6,7); 3,384(0,8); 3,366(2,5); 3,349(2,7); 3,325(21,0); 3,167(0,8); 3,149(2,2); 3,132(2,2); 3,114(0,7); 2,524(1,2); 2,511(11,9); 2,506(24,6); 2,501(33,8); 2,497(23,8); 2,492(10,8); 2,363(1,0); 2,344(3,1); 2,325(3,2); 2,306(1,0); 2,176(16,0); 1,106(2,7); 1,088(5,7); 1,071(2,7); 1,048(4,9); 1,029(12,5); 1,014(6,1); 1,010(5,9); 0,997(2,5); 0,008(0,5); 0,000(13,2) II, 681 (0.7); 7,242 (6.7); 3,384 (0.8); 3,366 (2.5); 3,349 (2.7); 3,325 (21.0); 3,167 (0.8); 3,149 (2.2); 3,132 (2.2); 3,114 (0.7); 2,524 (1.2); 2,511 (11.9); 2,506 (24.6); 2,501 (33.8); 2,497 (23.8); 2,492 (10.8); 2,363 (1.0); 2.344 (3.1); 2,325 (3.2); 2,306 (1.0); 2,176 (16.0); 1,106 (2.7); 1,088 (5.7); 1,071 (2.7); 1,048 (4.9); 1,029 (12.5); 1,014 (6.1); 1,010 (5.9); 0.997 (2.5); 0.008 (0.5); 0.000 (13.2)
Verbindung Nr.2597, Lösungsmittel [DMSO], 400 MHz Compound No. 2597, Solvent [DMSO], 400 MHz
12,388(0,7); 10,055(0,9); 8,132(4,4); 4,114(3,5); 4,100(3,5); 3,643(16,0); 3,317(146,7); 3,205(0,6); 2,670(0,7); 2,523(1,9); 2,510(37,7); 2,506(79,7); 2,501(109,1); 12,388 (0.7); 10,055 (0.9); 8,132 (4.4); 4,114 (3.5); 4,100 (3.5); 3,643 (16.0); 3.317 (146.7); 3,205 (0.6); 2,670 (0.7); 2,523 (1.9); 2,510 (37.7); 2,506 (79.7); 2.501 (109.1);
2,496(76,7); 2,492(34,4); 2,456(0,8); 2,438(2,4); 2,419(2,4); 2,401(0,9); 2,328(0,6); 2,289(10,1); 1,090(3,1); 1,072(7,1); 1,053(3,0); 0,008(1,3); 0,000(39,7); -0,009(1,1) Verbindung Nr.2485, Lösungsmittel [DMSO], 400 MHz 2,496 (76.7); 2,492 (34.4); 2,456 (0.8); 2.438 (2.4); 2,419 (2.4); 2,401 (0.9); 2,328 (0.6); 2,289 (10.1); 1,090 (3.1); 1,072 (7.1); 1,053 (3.0); 0.008 (1.3); 0,000 (39.7); -0.009 (1.1) Compound No. 2485, solvent [DMSO], 400 MHz
12,262(1,1); 7,568(6,4); 3,394(19,8); 3,361(7,6); 3,343(6,9); 3,325(2,3); 3,168(0,9); 12.262 (1.1); 7,568 (6.4); 3,394 (19.8); 3,361 (7.6); 3,343 (6.9); 3,325 (2.3); 3,168 (0.9);
3,162(1,8); 3,144(5,8); 3,126(5,9); 3,109(1,8); 2,675(0,9); 2,670(1,2); 2,665(0,8);3,162 (1.8); 3,144 (5.8); 3,126 (5.9); 3,109 (1.8); 2,675 (0.9); 2,670 (1.2); 2,665 (0.8);
2,523(3,1); 2,519(4,6); 2,510(70,5); 2,506(151,0); 2,501(207,0); 2,496(144,9); 2,523 (3.1); 2,519 (4.6); 2,510 (70.5); 2.506 (151.0); 2.501 (207.0); 2.496 (144.9)
2,492(65,4); 2,325(25,8); 1,100(7,2); 1,082(16,0); 1,065(7,1); 1,041(6,8); 1,024(15,1); 1 ,006(6,5); 0,008(2,2); 0,000(77,3); -0,009(2,3)  2,492 (65.4); 2,325 (25.8); 1,100 (7.2); 1,082 (16.0); 1,065 (7.1); 1,041 (6.8); 1,024 (15.1); 1, 006 (6.5); 0.008 (2.2); 0,000 (77.3); -0.009 (2.3)
Verbindung Nr.2600, Lösungsmittel [DMSO], 400 MHz Compound No. 2600, solvent [DMSO], 400 MHz
3,501(16,0); 2,522(1,3); 2,517(1,8); 2,514(1,4); 2,283(0,6) Verbindung Nr.2471, Lösungsmittel [DMSO], 400 MHz 3,501 (16.0); 2,522 (1.3); 2,517 (1.8); 2,514 (1.4); 2.283 (0.6) Compound No. 2471, solvent [DMSO], 400 MHz
12,359(1,2); 7,467(4,9); 7,451(4,8); 5,153(2,6); 4,373(1,2); 4,307(2,1); 4,185(2,6); 12.359 (1.2); 7,467 (4.9); 7,451 (4.8); 5,153 (2.6); 4,373 (1.2); 4.307 (2.1); 4.185 (2.6);
4,167(7,6); 4,149(7,8); 4,132(3,1); 4,124(2,4); 4,094(1,8); 4,076(1,8); 3,573(9,9); 4,167 (7.6); 4,149 (7.8); 4,132 (3.1); 4,124 (2.4); 4,094 (1.8); 4,076 (1.8); 3,573 (9.9);
3,416(2,0); 3,382(2,2); 3,137(1,2); 3,111(1,9); 2,725(1,4); 2,670(1,8); 2,604(0,8);  3,416 (2.0); 3.382 (2.2); 3,137 (1.2); 3,111 (1.9); 2,725 (1.4); 2,670 (1.8); 2,604 (0.8);
2,505(221,2); 2,501(300,1); 2,497(245,7); 2,445(1,7); 2,301(16,4); 2,284(13,8);  2.505 (221.2); 2.501 (300.1); 2.497 (245.7); 2,445 (1.7); 2,301 (16.4); 2,284 (13.8);
2,151 (1 ,6); 2,120(1 ,8); 2,057(1 ,2); 2,025(1 ,4); 1 ,682(4,6); 1 ,654(5,0); 1 ,525(2,3); 2,151 (1,6); 2,120 (1, 8); 2,057 (1, 2); 2.025 (1, 4); 1, 682 (4,6); 1, 654 (5.0); 1, 525 (2,3);
1,482(1,5); 1,323(1,6); 1,292(2,1); 1,241(8,1); 1,224(16,0); 1,206(8,3); 1,195(6,0); 1,482 (1.5); 1.323 (1.6); 1,292 (2.1); 1,241 (8.1); 1,224 (16.0); 1.206 (8.3); 1,195 (6.0);
1,178(10,4); 1,160(5,1); 0,000(72,6) 1,178 (10.4); 1,160 (5.1); 0.000 (72.6)
Verbindung Nr.2489, Lösungsmittel [DMSO], 400 MHz Compound No. 2489, solvent [DMSO], 400 MHz
14,204(0,9); 12,828(2,5); 9,511 (2,8); 9,022(2,5); 8,382(9,3); 7,672(6,2); 3,323(114,9); 3,280(5,8); 3,236(1,1); 2,670(3,7); 2,505(469,2); 2,501(482,1); 2,403(25,6); 14.204 (0.9); 12,828 (2.5); 9,511 (2.8); 9,022 (2.5); 8,382 (9.3); 7,672 (6.2); 3.323 (114.9); 3,280 (5.8); 3,236 (1.1); 2,670 (3.7); 2.505 (469.2); 2.501 (482.1); 2,403 (25.6);
2,328(3,0); 1,120(8,5); 1,101(16,0); 1,084(7,5); 0,002(67,4); 0,000(86,3) Verbindung Nr.2581, Lösungsmittel [DMSO], 400 MHz 2,328 (3.0); 1,120 (8.5); 1,101 (16.0); 1,084 (7.5); 0.002 (67.4); 0.000 (86.3) Compound No. 2581, solvent [DMSO], 400 MHz
12,329(1,1); 7,539(7,2); 5,145(1,6); 5,133(1,5); 4,370(0,8); 4,335(0,8); 4,302(1,2); 4,291(1,2); 4,184(2,1); 4,166(6,7); 4,148(6,9); 4,142(2,1); 4,130(2,3); 4,124(1,8); 4,107(0,7); 4,092(1,6); 4,074(1,6); 4,065(0,9); 4,056(0,5); 4,047(0,8); 3,466(7,1);  12.329 (1.1); 7,539 (7.2) 5,145 (1.6); 5,133 (1.5); 4,370 (0.8); 4,335 (0.8); 4,302 (1.2); 4,291 (1.2); 4,184 (2.1); 4,166 (6.7); 4,148 (6.9); 4,142 (2.1); 4,130 (2.3); 4,124 (1.8); 4,107 (0.7); 4,092 (1.6); 4,074 (1.6); 4,065 (0.9); 4,056 (0.5); 4,047 (0.8); 3,466 (7.1);
3,413(1,6); 3,374(1,3); 3,120(0,6); 3,096(1,0); 3,090(1,0); 3,065(0,5); 2,715(0,7); 3,413 (1.6); 3,374 (1.3); 3,120 (0.6); 3,096 (1.0); 3,090 (1.0); 3,065 (0.5); 2,715 (0.7);
2,679(0,6); 2,675(0,7); 2,670(0,9); 2,666(0,6); 2,524(2,1); 2,519(3,3); 2,510(50,2); 2,506(106,7); 2,501(145,6); 2,496(102,7); 2,492(47,1); 2,341(15,2); 2,324(12,7); 2,679 (0.6); 2,675 (0.7); 2,670 (0.9); 2,666 (0.6); 2,524 (2.1); 2,519 (3.3); 2,510 (50.2); 2.506 (106.7); 2.501 (145.6); 2.496 (102.7); 2,492 (47.1); 2,341 (15.2); 2,324 (12.7);
2,149(0,9); 2,113(0,9); 2,053(0,7); 2,019(0,8); 1,680(2,7); 1,651(2,9); 1,624(0,7); 2,149 (0.9); 2,113 (0.9); 2,053 (0.7); 2,019 (0.8); 1,680 (2.7); 1,651 (2.9); 1,624 (0.7);
1,608(0,5); 1,558(0,6); 1,526(1,2); 1,480(0,8); 1,448(0,6); 1,319(0,9); 1,289(1,1); 1,608 (0.5); 1.558 (0.6); 1,526 (1.2); 1,480 (0.8); 1,448 (0.6); 1,319 (0.9); 1,289 (1.1);
1,242(7,9); 1,224(16,0); 1,207(7,9); 1,201(5,7); 1,183(10,4); 1,165(4,8); 0,008(1,5); 0,000(51,5); -0,009(1,7) 1,242 (7.9); 1,224 (16.0); 1,207 (7.9); 1,201 (5.7); 1,183 (10.4); 1.165 (4.8); 0.008 (1.5); 0,000 (51.5); -0.009 (1.7)
Verbindung Nr.2375, Lösungsmittel [DMSO], 400 MHz Compound No. 2375, solvent [DMSO], 400 MHz
12,282(0,5); 7,515(4,8); 3,462(3,8); 3,386(1,7); 3,369(4,4); 3,351(4,4); 3,333(1,6); 3,168(1,4); 3,151(4,0); 3,133(4,1); 3,116(1,4); 2,670(0,6); 2,506(82,5); 2,501(107,7); 2,497(78,9); 2,449(0,7); 2,328(0,7); 2,286(16,0); 1,105(4,7); 1,087(10,1); 1,069(4,8); 1,046(4,7); 1,028(9,7); 1,011(4,4); 0,000(30,2)  12.282 (0.5); 7,515 (4.8); 3,462 (3.8); 3,386 (1.7); 3,369 (4.4); 3,351 (4.4); 3.333 (1.6); 3,168 (1.4); 3,151 (4.0); 3,133 (4.1); 3,116 (1.4); 2,670 (0.6); 2,506 (82.5); 2.501 (107.7); 2,497 (78.9); 2,449 (0.7); 2,328 (0.7); 2.286 (16.0); 1,105 (4.7); 1,087 (10.1); 1,069 (4.8); 1,046 (4.7); 1.028 (9.7); 1,011 (4.4); 0.000 (30.2)
Verbindung Nr.2533, Lösungsmittel [DMSO], 400 MHz Compound No. 2533, solvent [DMSO], 400 MHz
14,151(2,1); 12,819(4,2); 9,641(3,9); 8,954(3,0); 8,387(16,0); 7,640(8,5); 3,434(23,1); 3,425(12,0); 3,372(4,3); 3,315(862,0); 3,264(60,7); 2,669(14,3); 2,590(3,3); 14,151 (2.1); 12.819 (4.2); 9.641 (3.9); 8.954 (3.0); 8,387 (16.0); 7,640 (8.5); 3,434 (23.1); 3,425 (12.0); 3,372 (4.3); 3.315 (862.0); 3,264 (60.7); 2,669 (14.3); 2,590 (3.3);
2,555(11,7); 2,505(2167,4); 2,501(2396,5); 2,496(1632,8); 2,407(44,8); 2,327(14,6); 2,073(2,0); 0,146(3,1); 0,000(750,3); -0,009(51,0); -0,150(3,8) Verbindung Nr.2490, Lösungsmittel [DMSO], 400 MHz 2,555 (11.7); 2.505 (2167.4); 2.501 (2396.5); 2.496 (1632.8); 2,407 (44.8); 2,327 (14.6); 2,073 (2.0); 0.146 (3.1); 0.000 (750.3); -0.009 (51.0); -0.150 (3.8) Compound No. 2490, solvent [DMSO], 400 MHz
12,824(2,2); 9,573(2,3); 8,382(9,7); 7,654(1,2); 3,317(99,1); 3,267(2,3); 3,251(5,3); 3,236(5,7); 3,218(2,5); 2,675(1,5); 2,670(1,7); 2,505(253,6); 2,501(277,2);  12.824 (2.2); 9.573 (2.3); 8,382 (9.7); 7,654 (1.2) 3,317 (99.1); 3,267 (2.3); 3,251 (5.3); 3,236 (5.7); 3,218 (2.5); 2,675 (1.5); 2,670 (1.7); 2.505 (253.6); 2.501 (277.2);
2,496(184,9); 2,404(25,2); 2,328(1,8); 1,543(0,6); 1,524(2,5); 1,507(4,9); 1,489(5,1); 1,471(2,8); 1,453(0,7); 0,900(8,0); 0,881(16,0); 0,863(7,2); 0,000(92,4); -0,009(5,9) 2.496 (184.9); 2,404 (25.2); 2,328 (1.8); 1.543 (0.6); 1.524 (2.5); 1,507 (4.9); 1,489 (5.1); 1,471 (2.8); 1,453 (0.7); 0.900 (8.0); 0.881 (16.0); 0.863 (7.2); 0,000 (92.4); -0.009 (5.9)
Verbindung Nr.2510, Lösungsmittel [DMSO], 400 MHz Compound No. 2510, solvent [DMSO], 400 MHz
12,807(0,6); 9,534(0,6); 8,378(4,6); 3,324(1,0); 3,314(22,0); 3,292(1,2); 3,289(1,2); 3,274(0,8); 2,524(0,5); 2,519(0,8); 2,511(12,6); 2,506(27,1); 2,501(37,3); 2,497(26,1); 2,492(11,8); 2,403(10,1); 1,606(0,6); 1,590(0,8); 1,573(0,7); 1,411(0,9); 1,394(1,8); 1,375(1,8); 1,358(0,8); 0,899(16,0); 0,883(15,1); 0,008(0,7); 0,000(22,1); -0,009(0,6) 12.807 (0.6); 9.534 (0.6); 8,378 (4.6); 3,324 (1.0); 3,314 (22.0) 3,292 (1.2); 3,289 (1.2); 3,274 (0.8); 2,524 (0.5); 2,519 (0.8); 2,511 (12.6); 2,506 (27.1); 2,501 (37.3); 2,497 (26.1); 2,492 (11.8); 2,403 (10.1); 1,606 (0.6); 1,590 (0.8); 1,573 (0.7); 1,411 (0.9); 1,394 (1.8); 1.375 (1.8); 1.358 (0.8); 0.899 (16.0); 0.883 (15.1); 0.008 (0.7); 0,000 (22.1); -0.009 (0.6)
Verbindung Nr.2546, Lösungsmittel [DMSO], 400 MHz Compound No. 2546, solvent [DMSO], 400 MHz
9,843(0,7); 8,971(1,2); 8,382(5,2); 7,648(3,5); 7,645(3,4); 4,166(0,5); 4,119(3,1); 9,843 (0.7); 8,971 (1.2); 8,382 (5.2); 7,648 (3.5); 7,645 (3.4); 4,166 (0.5); 4,119 (3.1);
4,105(3,1); 3,795(1,2); 3,780(1,3); 3,723(1,0); 3,673(1,1); 3,646(16,0); 3,615(5,6); 3,413(0,6); 3,369(0,6); 3,351(0,8); 3,317(85,5); 3,267(0,6); 3,131(0,5); 2,679(0,6); 2,674(1,3); 2,670(2,0); 2,665(1,4); 2,660(0,6); 2,604(0,7); 2,599(2,0); 2,595(2,0); 4,105 (3.1); 3,795 (1.2); 3,780 (1.3); 3,723 (1.0); 3,673 (1.1); 3,646 (16.0); 3,615 (5.6); 3,413 (0.6); 3,369 (0.6); 3,351 (0.8); 3,317 (85.5); 3,267 (0.6); 3,131 (0.5); 2,679 (0.6); 2,674 (1.3); 2,670 (2.0); 2,665 (1.4); 2,660 (0.6); 2,604 (0.7); 2,599 (2.0); 2,595 (2.0);
2,590(1,5); 2,561(1,0); 2,556(1,1); 2,552(0,9); 2,534(0,5); 2,523(3,7); 2,518(6,1); 2,590 (1.5); 2,561 (1.0); 2,556 (1.1); 2,552 (0.9); 2,534 (0.5); 2,523 (3.7); 2,518 (6.1);
2,510(110,1); 2,505(239,2); 2,501(330,6); 2,496(230,8); 2,491(104,2); 2,474(2,0); 2,470(1,6); 2,465(1,0); 2,460(0,9); 2,455(1,1); 2,451(1,5); 2,446(1,0); 2,441(0,6); 2,510 (110.1); 2.505 (239.2); 2.501 (330.6); 2.496 (230.8); 2.491 (104.2); 2,474 (2.0); 2,470 (1.6); 2.465 (1.0); 2,460 (0.9); 2.455 (1.1); 2,451 (1.5); 2,446 (1.0); 2,441 (0.6);
2,418(11,0); 2,337(0,7); 2,332(1,4); 2,327(2,0); 2,323(1,4); 2,318(0,6); 2,073(0,5); 1,176(1,0); 0,146(0,6); 0,099(1,3); 0,008(5,5); 0,000(214,5); -0,009(6,6); -0,031(0,7); - 0,050(0,9); -0,150(0,7) 2,418 (11.0); 2,337 (0.7); 2,332 (1.4); 2,327 (2.0); 2,323 (1.4); 2,318 (0.6); 2,073 (0.5); 1,176 (1.0); 0.146 (0.6); 0.099 (1.3); 0.008 (5.5); 0.000 (214.5); -0.009 (6.6); -0.031 (0.7); - 0.050 (0.9); -0.150 (0.7)
Verbindung Nr.2290, Lösungsmittel [DMSO], 400 MHz Compound No. 2290, solvent [DMSO], 400 MHz
12,851(0,5); 9,563(0,6); 8,153(4,1); 3,332(1,2); 3,314(138,1); 3,300(1,8); 3,282(0,9); 2,674(0,7); 2,670(1,1); 2,665(0,7); 2,523(2,4); 2,519(3,5); 2,510(61,6); 2,505(133,0); 2,501(183,0); 2,496(129,0); 2,492(59,2); 2,455(0,6); 2,450(0,7); 2,446(0,6);  12.851 (0.5); 9.563 (0.6); 8,153 (4.1); 3,332 (1.2); 3,314 (138.1); 3,300 (1.8); 3,282 (0.9); 2,674 (0.7); 2,670 (1.1); 2,665 (0.7); 2,523 (2.4); 2,519 (3.5); 2,510 (61.6); 2.505 (133.0); 2.501 (183.0); 2.496 (129.0); 2,492 (59.2); 2.455 (0.6); 2,450 (0.7); 2,446 (0.6);
2,349(10,1 ); 2,337(0,5); 2,332(0,9); 2,328(1 ,1 ); 2,323(0,8); 1 ,611 (0,6); 1 ,594(0,8); 1,577(0,7); 1,418(1,0); 1,400(1,9); 1,382(1,9); 1,364(0,8); 0,902(16,0); 0,885(15,2); 0,008(1,5); 0,000(58,5); -0,009(1,9) 2,349 (10.1); 2,337 (0.5); 2,332 (0.9); 2,328 (1, 1); 2,323 (0.8); 1, 611 (0.6); 1, 594 (0.8); 1,577 (0.7); 1,418 (1.0); 1,400 (1.9); 1,382 (1.9); 1.364 (0.8); 0.902 (16.0); 0.885 (15.2); 0.008 (1.5); 0,000 (58.5); -0.009 (1.9)
Verbindung Nr.2265, Lösungsmittel [DMSO], 400 MHz Compound No. 2265, solvent [DMSO], 400 MHz
7,455(5,5); 3,389(1,7); 3,371(4,3); 3,354(4,5); 3,336(2,0); 3,316(43,2); 3,170(1,3); 3,152(3,8); 3,134(3,9); 3,117(1,4); 2,538(1,8); 2,524(2,5); 2,519(2,8); 2,510(22,4); 2,506(46,4); 2,501(63,5); 2,497(46,9); 2,492(24,3); 2,333(0,5); 2,328(0,6); 2,324(0,5); 2,267(16,0); 1,106(4,7); 1,089(9,8); 1,071(5,0); 1,046(4,6); 1,029(9,2); 1,011(4,4); 0,008(0,5); 0,000(14,9); -0,009(0,8) 7.455 (5.5); 3,389 (1.7); 3,371 (4.3); 3.354 (4.5); 3,336 (2.0); 3,316 (43.2); 3,170 (1.3); 3,152 (3.8); 3,134 (3.9); 3,117 (1.4); 2,538 (1.8); 2,524 (2.5); 2,519 (2.8); 2,510 (22.4); 2,506 (46.4); 2,501 (63.5); 2,497 (46.9); 2,492 (24.3); 2,333 (0.5); 2,328 (0.6); 2,324 (0.5); 2,267 (16.0); 1,106 (4.7); 1,089 (9.8); 1,071 (5.0); 1,046 (4.6); 1,029 (9.2); 1,011 (4.4); 0.008 (0.5); 0,000 (14.9); -0.009 (0.8)
Verbindung Nr.2270, Lösungsmittel [DMSO], 400 MHz Compound No. 2270, solvent [DMSO], 400 MHz
12,865(1,0); 9,601(1,1); 8,157(8,7); 3,315(32,7); 3,276(1,9); 3,259(3,7); 3,244(3,7); 3,227(2,0); 2,524(0,8); 2,519(1 ,4); 2,511 (18,2); 2,506(38,1 ); 2,502(51 ,7); 2,497(37,4); 2,493(18,1); 2,350(23,2); 2,333(0,5); 1,532(2,1); 1,514(3,9); 1,496(3,9); 1,478(2,3); 1,460(0,5); 0,905(7,5); 0,886(16,0); 0,868(6,7); 0,008(0,6); 0,000(17,3); -0,005(0,7); - 0,006(0,6); -0,009(0,8) 12.865 (1.0); 9.601 (1.1); 8,157 (8.7); 3,315 (32.7); 3,276 (1.9); 3,259 (3.7); 3,244 (3.7); 3,227 (2.0); 2,524 (0.8); 2,519 (1, 4); 2,511 (18,2); 2,506 (38.1); 2,502 (51, 7); 2,497 (37.4); 2,493 (18.1); 2,350 (23.2); 2,333 (0.5); 1,532 (2.1); 1,514 (3.9); 1,496 (3.9); 1,478 (2.3); 1,460 (0.5); 0.905 (7.5); 0.886 (16.0); 0.868 (6.7); 0.008 (0.6); 0,000 (17.3); -0.005 (0.7); - 0.006 (0.6); -0.009 (0.8)
Verbindung Nr.2313, Lösungsmittel [DMSO], 400 MHz Compound No. 2313, solvent [DMSO], 400 MHz
12,857(2,1 ); 9,670(2,1 ); 8,163(16,0); 3,484(1 ,4); 3,478(1 ,8); 3,474(2,0); 3,466(5,2); 3,454(6,8); 3,450(6,0); 3,443(14,8); 3,433(9,1); 3,420(2,7); 3,414(1,6); 3,373(1,1); 3,367(1,4); 3,315(68,0); 3,268(72,6); 3,236(0,6); 3,218(0,6); 3,169(0,6); 2,671(0,7); 2,666(0,5); 2,557(3,9); 2,552(4,0); 2,548(3,6); 2,543(3,6); 2,524(5,1); 2,519(5,6); 12,857 (2,1); 9,670 (2.1); 8.163 (16.0); 3.484 (1, 4); 3.478 (1, 8); 3,474 (2.0); 3,466 (5.2); 3,454 (6.8); 3,450 (6.0); 3,443 (14.8); 3,433 (9.1); 3,420 (2.7); 3,414 (1.6); 3,373 (1.1); 3,367 (1.4); 3,315 (68.0); 3,268 (72.6); 3,236 (0.6); 3,218 (0.6); 3,169 (0.6); 2,671 (0.7); 2,666 (0.5); 2,557 (3.9); 2,552 (4.0); 2,548 (3.6); 2,543 (3.6); 2,524 (5.1); 2,519 (5.6);
2,511(39,1); 2,506(81,0); 2,501(111,4); 2,497(82,7); 2,492(43,4); 2,461(1,2); 2,511 (39.1); 2,506 (81.0); 2.501 (111.4); 2,497 (82.7); 2,492 (43.4); 2,461 (1.2);
2,457(1 ,3); 2,452(1 ,2); 2,447(0,6); 2,427(0,8); 2,412(0,7); 2,405(0,7); 2,353(38,1 ); 2,333(1,4); 2,328(1,2); 2,324(0,7); 0,008(0,9); 0,000(26,0); -0,009(1,4) 2,457 (1, 3); 2,452 (1, 2); 2,447 (0.6); 2,427 (0.8); 2.412 (0.7); 2.405 (0.7); 2,353 (38.1); 2,333 (1.4); 2,328 (1.2); 2,324 (0.7); 0.008 (0.9); 0,000 (26.0); -0.009 (1.4)
Verbindung Nr.2269, Lösungsmittel [DMSO], 400 MHz Compound No. 2669, solvent [DMSO], 400 MHz
12,865(1,1); 9,540(1,3); 8,157(8,6); 3,366(0,6); 3,339(1,1); 3,321(6,8); 3,314(55,7); 3,307(7,8); 3,303(5,8); 3,289(4,0); 3,271 (1 ,5); 3,265(1 ,1 ); 2,561 (0,8); 2,557(0,9);  12.865 (1.1); 9.540 (1.3); 8,157 (8.6); 3,366 (0.6); 3,339 (1.1); 3,321 (6.8); 3,314 (55.7); 3.307 (7.8); 3,303 (5.8); 3,289 (4.0); 3,271 (1, 5); 3,265 (1, 1); 2.561 (0.8); 2,557 (0.9);
2,552(0,7); 2,524(0,8); 2,510(30,8); 2,506(63,7); 2,501(85,9); 2,497(64,2); 2,492(32,9); 2,456(1,4); 2,452(1,4); 2,447(0,9); 2,348(23,4); 2,328(0,8); 2,324(0,6); 1,126(7,4); 1,108(16,0); 1,090(7,4); 0,008(0,9); 0,000(21,8); -0,008(1,3) Verbindung Nr.4069, Lösungsmittel [DMSO], 400 MHz  2,552 (0.7); 2,524 (0.8); 2,510 (30.8); 2,506 (63.7); 2,501 (85.9); 2,497 (64.2); 2,492 (32.9); 2,456 (1.4); 2,452 (1.4); 2,447 (0.9); 2,348 (23.4); 2,328 (0.8); 2,324 (0.6); 1,126 (7.4); 1,108 (16.0); 1,090 (7.4); 0.008 (0.9); 0,000 (21.8); -0.008 (1.3) Compound No.4069, solvent [DMSO], 400 MHz
12,004(0,7); 8,182(0,7); 7,724(2,2); 7,630(1,3); 4,252(6,7); 4,013(3,4); 3,694(16,0); 12,004 (0.7); 8,182 (0.7); 7,724 (2.2); 7,630 (1.3); 4,252 (6.7); 4,013 (3.4); 3,694 (16.0);
3,615(0,9); 3,600(9,5); 3,353(5,0); 3,169(1,0); 3,013(8,4); 2,876(14,9); 2,712(1,1);3,615 (0.9); 3,600 (9.5); 3,353 (5.0); 3,169 (1.0); 3,013 (8.4); 2,876 (14.9); 2,712 (1.1);
2,693(1,4); 2,679(1,2); 2,674(1,7); 2,670(2,0); 2,665(1,6); 2,645(0,6); 2,533(0,7); 2,693 (1.4); 2,679 (1.2); 2,674 (1.7); 2,670 (2.0); 2,665 (1.6); 2,645 (0.6); 2,533 (0.7);
2,523(3,5); 2,519(5,0); 2,510(64,7); 2,505(140,6); 2,501(195,7); 2,496(135,4);  2,523 (3.5); 2,519 (5.0); 2,510 (64.7); 2.505 (140.6); 2.501 (195.7); 2.496 (135.4);
2,491(60,1); 2,332(0,9); 2,327(1,2); 2,323(0,8); 1,180(2,6); 1,162(5,7); 1,143(2,7);2,491 (60.1); 2,332 (0.9); 2,327 (1.2); 2,323 (0.8); 1,180 (2.6); 1,162 (5.7); 1.143 (2.7);
1,139(2,6); 1,120(3,3); 1,101(1,4); 0,008(1,6); 0,006(0,5); 0,005(0,6); 0,004(0,8); 1,139 (2.6); 1,120 (3.3); 1,101 (1.4); 0.008 (1.6); 0.006 (0.5); 0,005 (0.6); 0.004 (0.8);
0,000(50,9); -0,009(1,4)  0,000 (50.9); -0.009 (1.4)
Verbindung Nr.3993, Lösungsmittel [DMSO], 400 MHz Compound No. 3993, solvent [DMSO], 400 MHz
7,511 (1 ,7); 7,473(1 ,7); 4,171 (4,3); 4,070(3,3); 3,674(12,9); 3,607(9,4); 3,470(16,0); 3,168(2,2); 2,946(7,8); 2,918(11,7); 2,674(0,9); 2,670(1,2); 2,665(1,0); 2,523(4,0); 2,518(5,8); 2,510(78,8); 2,505(170,8); 2,500(237,1); 2,496(164,0); 2,491(72,4); 7,511 (1, 7); 7,473 (1, 7); 4,171 (4,3); 4,070 (3.3); 3,674 (12.9); 3,607 (9.4); 3,470 (16.0); 3,168 (2.2); 2,946 (7.8); 2,918 (11.7); 2,674 (0.9); 2,670 (1.2); 2,665 (1.0); 2,523 (4.0); 2,518 (5.8); 2,510 (78.8); 2.505 (170.8); 2,500 (237.1); 2.496 (164.0); 2,491 (72.4);
2,332(1,0); 2,327(1,5); 2,322(1,3); 2,309(4,8); 2,288(3,8); 2,072(1,1); 0,008(1,2); 2,332 (1.0); 2,327 (1.5); 2,322 (1.3); 2,309 (4.8); 2,288 (3.8); 2,072 (1.1); 0.008 (1.2);
0,000(42,8); -0,009(1,3) Verbindung Nr.3977, Lösungsmittel [DMSO], 400 MHz 0,000 (42.8); -0.009 (1.3) Compound No. 3977, solvent [DMSO], 400 MHz
12,308(0,9); 7,403(3,8); 7,382(3,7); 5,158(1,7); 5,146(1,5); 4,383(0,8); 4,350(0,8); 4,319(1,2); 4,308(1,2); 4,185(2,2); 4,167(7,0); 4,157(1,1); 4,149(7,3); 4,139(2,1); 4,132(2,5); 4,121(2,0); 4,113(0,6); 4,104(0,7); 4,096(1,6); 4,078(1,6); 4,069(0,8); 4,060(0,6); 4,051(0,8); 3,417(0,9); 3,385(1,1); 3,313(125,6); 3,150(0,6); 3,141(0,7); 3,110(1,1); 3,086(0,6); 2,730(0,7); 2,675(0,7); 2,670(1,0); 2,665(0,7); 2,523(2,7); 2,518(4,1); 2,510(54,3); 2,505(116,1); 2,501(160,8); 2,496(112,8); 2,492(51,2); 2,450(0,5); 2,332(0,8); 2,328(1,1); 2,323(0,8); 2,283(12,2); 2,266(10,2); 2,152(1,0); 2,117(1,0); 2,072(0,6); 2,057(0,7); 2,023(0,9); 1,686(2,9); 1,674(2,4); 1,655(3,1); 1,627(0,7); 1,612(0,6); 1,558(0,6); 1,527(1,4); 1,484(0,8); 1,453(0,7); 1,324(1,0); 1,296(1,3); 1,257(1,2); 1,242(7,6); 1,224(16,0); 1,206(7,5); 1,193(5,2); 1,175(10,1); 1,157(4,7); 0,008(1,9); 0,000(63,2); -0,009(2,0) Verbindung Nr.2840, Lösungsmittel [DMSO], 400 MHz  12.308 (0.9); 7,403 (3.8) 7,382 (3.7); 5.158 (1.7); 5,146 (1.5); 4,383 (0.8); 4,350 (0.8); 4.319 (1.2); 4,308 (1.2); 4.185 (2.2); 4,167 (7.0); 4,157 (1.1); 4,149 (7.3); 4,139 (2.1); 4,132 (2.5); 4,121 (2.0); 4,113 (0.6); 4,104 (0.7); 4.096 (1.6); 4,078 (1.6); 4,069 (0.8); 4,060 (0.6); 4,051 (0.8); 3,417 (0.9); 3,385 (1.1); 3,313 (125.6); 3,150 (0.6); 3,141 (0.7); 3,110 (1.1); 3,086 (0.6); 2,730 (0.7); 2,675 (0.7); 2,670 (1.0); 2,665 (0.7); 2,523 (2.7); 2,518 (4.1); 2,510 (54.3); 2.505 (116.1); 2.501 (160.8); 2.496 (112.8); 2,492 (51.2); 2,450 (0.5); 2,332 (0.8); 2,328 (1.1); 2,323 (0.8); 2,283 (12.2); 2,266 (10.2); 2,152 (1.0); 2,117 (1.0); 2,072 (0.6); 2,057 (0.7); 2,023 (0.9); 1,686 (2.9); 1,674 (2.4); 1,655 (3.1); 1,627 (0.7); 1,612 (0.6); 1.558 (0.6); 1,527 (1.4); 1,484 (0.8); 1,453 (0.7); 1,324 (1.0); 1.296 (1.3); 1.257 (1.2); 1,242 (7.6); 1,224 (16.0); 1.206 (7.5); 1.193 (5.2); 1.175 (10.1); 1,157 (4.7); 0.008 (1.9); 0,000 (63.2); -0.009 (2.0) Compound No. 2840, solvent [DMSO], 400 MHz
12,248(0,5); 9,762(0,6); 8,108(3,6); 3,333(17,4); 3,305(1,5); 3,290(1,3); 3,288(1,3); 12.248 (0.5); 9.762 (0.6); 8,108 (3.6); 3.333 (17.4); 3,305 (1.5); 3,290 (1.3); 3,288 (1.3);
3,272(0,9); 2,588(0,6); 2,569(1,9); 2,550(2,0); 2,531(0,7); 2,524(0,7); 2,519(0,9);3,272 (0.9); 2,588 (0.6); 2,569 (1.9); 2,550 (2.0); 2,531 (0.7); 2,524 (0.7); 2,519 (0.9);
2,510(11,5); 2,506(24,4); 2,501(33,7); 2,497(23,6); 2,492(10,6); 2,086(10,8); 2,510 (11.5); 2,506 (24.4); 2,501 (33.7); 2,497 (23.6); 2,492 (10.6); 2,086 (10.8);
1,615(0,6); 1,598(0,8); 1,581(0,7); 1,408(1,0); 1,391(1,9); 1,372(1,9); 1,355(0,8); 1,129(2,4); 1,111(5,8); 1,092(2,4); 0,902(16,0); 0,885(15,2); 0,000(13,8)  1,615 (0.6); 1,598 (0.8); 1,581 (0.7); 1,408 (1.0); 1,391 (1.9); 1.372 (1.9); 1.355 (0.8); 1.129 (2.4); 1,111 (5.8); 1,092 (2.4); 0.902 (16.0); 0.885 (15.2); 0.000 (13.8)
Verbindung Nr.2911, Lösungsmittel [DMSO], 400 MHz Compound No. 2911, solvent [DMSO], 400 MHz
7,279(3,6); 7,263(6,1); 5,154(1,2); 5,142(1,2); 4,388(0,5); 4,297(0,9); 4,285(0,8); 7,279 (3.6); 7,263 (6.1); 5,154 (1.2); 5,142 (1.2); 4,388 (0.5); 4,297 (0.9); 4,285 (0.8);
4,180(1,5); 4,162(4,9); 4,144(5,4); 4,135(0,7); 4,127(2,2); 4,118(1,3); 4,100(1,4); 4,084(1 ,4); 4,066(1 ,2); 4,057(0,6); 4,039(0,6); 3,792(1 ,3); 3,425(0,7); 3,392(0,9);4,180 (1.5); 4,162 (4.9); 4,144 (5.4); 4,135 (0.7); 4,127 (2.2); 4,118 (1.3); 4,100 (1.4); 4.084 (1, 4); 4.066 (1, 2); 4,057 (0.6); 4,039 (0.6); 3,792 (1, 3); 3,425 (0.7); 3,392 (0.9);
3,169(1,1); 3,091(0,7); 3,083(0,7); 2,761(0,5); 2,524(1,0); 2,511(16,3); 2,506(34,6);3,169 (1.1); 3,091 (0.7); 3,083 (0.7); 2,761 (0.5); 2,524 (1.0); 2,511 (16.3); 2,506 (34.6);
2,501(48,5); 2,497(36,1); 2,492(16,5); 2,479(3,6); 2,469(2,0); 2,461(1,4); 2,449(0,5);2,501 (48.5); 2,497 (36.1); 2,492 (16.5); 2,479 (3.6); 2,469 (2.0); 2,461 (1.4); 2,449 (0.5);
2,150(0,8); 2,113(0,7); 2,047(0,5); 2,031(0,6); 2,017(16,0); 1,993(9,6); 1,681(1,8);2,150 (0.8); 2,113 (0.7) 2,047 (0.5); 2,031 (0.6); 2,017 (16.0); 1,993 (9.6); 1,681 (1.8);
1,666(1,3); 1,651(2,3); 1,526(1,2); 1,302(0,5); 1,280(0,7); 1,241(6,3); 1,223(12,3); 1,206(5,9); 1,173(3,3); 1,155(6,6); 1,138(3,2); 1,125(3,8); 1,114(2,9); 1,106(8,7);1,666 (1.3); 1,651 (2.3); 1,526 (1.2); 1,302 (0.5); 1,280 (0.7); 1,241 (6.3); 1.223 (12.3); 1.206 (5.9); 1,173 (3.3); 1,155 (6.6); 1,138 (3.2); 1.125 (3.8); 1,114 (2.9); 1,106 (8.7);
1,095(5,6); 1,087(4,0); 1,076(2,3); 0,008(0,7); 0,000(22,4); -0,009(0,7) Verbindung Nr.2820, Lösungsmittel [DMSO], 400 MHz 1,095 (5.6); 1,087 (4.0); 1,076 (2.3); 0.008 (0.7); 0,000 (22.4); -0.009 (0.7) Compound No. 2820, solvent [DMSO], 400 MHz
12,262(0,8); 9,816(0,5); 9,802(0,9); 8,113(5,3); 3,311(38,1); 3,266(1,3); 3,248(2,7); 3,234(2,7); 3,216(1,4); 2,589(0,9); 2,570(2,9); 2,551(3,2); 2,532(1,2); 2,524(0,9);  12.262 (0.8); 9.816 (0.5); 9,802 (0.9); 8,113 (5.3); 3,311 (38.1); 3,266 (1.3); 3,248 (2.7); 3,234 (2.7); 3,216 (1.4); 2,589 (0.9); 2,570 (2.9); 2,551 (3.2); 2,532 (1.2); 2,524 (0.9);
2,519(1,2); 2,510(14,6); 2,506(30,8); 2,501(42,3); 2,497(29,9); 2,492(13,5); 2,519 (1.2); 2,510 (14.6); 2,506 (30.8); 2,501 (42.3); 2,497 (29.9); 2,492 (13.5);
2,087(16,0); 1,521(1,5); 1,503(2,8); 1,485(2,8); 1,467(1,6); 1,131(3,7); 1,112(8,8); 1,093(3,6); 0,904(5,2); 0,886(10,8); 0,867(4,5); 0,008(0,6); 0,000(17,8); -0,009(0,6) 2,087 (16.0); 1,521 (1.5); 1,503 (2.8); 1,485 (2.8); 1,467 (1.6); 1,131 (3.7); 1,112 (8.8); 1,093 (3.6); 0.904 (5.2); 0.886 (10.8); 0.867 (4.5); 0.008 (0.6); 0,000 (17.8); -0.009 (0.6)
Verbindung Nr.2819, Lösungsmittel [DMSO], 400 MHz Compound No. 2819, solvent [DMSO], 400 MHz
12,267(0,7); 9,749(0,5); 9,736(0,9); 9,723(0,5); 8,113(5,3); 3,478(3,4); 3,328(0,7); 3,310(2,3); 3,296(2,6); 3,292(2,5); 3,278(2,3); 3,260(0,7); 2,587(0,9); 2,568(3,1);  12.267 (0.7); 9.749 (0.5); 9,736 (0.9); 9,723 (0.5); 8,113 (5.3); 3,478 (3.4); 3,328 (0.7); 3,310 (2.3); 3,296 (2.6); 3,292 (2.5); 3,278 (2.3); 3,260 (0.7); 2,587 (0.9); 2,568 (3.1);
2,550(3,2); 2,531(1,2); 2,524(0,7); 2,511(11,0); 2,506(22,0); 2,502(29,4); 2,497(20,5); 2,493(9,3); 2,087(16,0); 1,130(3,8); 1,119(5,4); 1,111(8,7); 1,100(10,7); 1,092(3,8); 1,082(4,8); 0,000(8,0) Verbindung Nr.2815, Lösungsmittel [DMSO], 400 MHz  2,550 (3.2); 2,531 (1.2); 2,524 (0.7); 2,511 (11.0); 2,506 (22.0); 2,502 (29.4); 2,497 (20.5); 2,493 (9.3); 2,087 (16.0); 1,130 (3.8); 1,119 (5.4); 1,111 (8.7); 1,100 (10.7); 1,092 (3.8); 1,082 (4.8); 0.000 (8.0) Compound No. 2815, solvent [DMSO], 400 MHz
7,229(6,0); 3,385(0,6); 3,367(1,9); 3,350(1,9); 3,332(0,7); 3,174(0,6); 3,169(0,5);  7.229 (6.0); 3,385 (0.6); 3,367 (1.9); 3,350 (1.9); 3,332 (0.7); 3,174 (0.6); 3,169 (0.5);
3,156(1,8); 3,139(1,8); 3,121(0,6); 2,511(6,1); 2,506(13,2); 2,501(18,8); 2,497(13,0); 3,156 (1.8); 3,139 (1.8); 3,121 (0.6); 2,511 (6.1); 2,506 (13.2); 2,501 (18.8); 2,497 (13.0);
2,492(5,9); 2,481(3,0); 2,463(3,0); 2,444(1,0); 1,999(16,0); 1,117(3,8); 1,104(2,7);2,492 (5.9); 2,481 (3.0); 2,463 (3.0); 2,444 (1.0); 1,999 (16.0); 1,117 (3.8); 1,104 (2.7);
1,098(9,5); 1,087(4,7); 1,079(4,4); 1,069(2,2); 1,042(2,1); 1,024(4,2); 1,006(2,0); 1,098 (9.5); 1,087 (4.7); 1,079 (4.4); 1,069 (2.2); 1,042 (2.1); 1,024 (4.2); 1,006 (2.0);
0,000(8,3) 0.000 (8.3)
Verbindung Nr.2817, Lösungsmittel [DMSO], 400 MHz Compound No. 2817, solvent [DMSO], 400 MHz
7,320(4,7); 7,300(3,2); 4,206(0,7); 4,157(6,0); 4,073(4,7); 4,062(0,9); 3,981(0,8);  7,320 (4.7); 7,300 (3.2); 4,206 (0.7); 4,157 (6.0); 4,073 (4.7); 4,062 (0.9); 3,981 (0.8);
3,670(16,0); 3,581(10,7); 3,169(0,8); 2,947(9,8); 2,924(1,7); 2,915(15,8); 2,895(1,8); 2,524(1,6); 2,519(1,6); 2,510(18,4); 2,506(40,5); 2,501(54,4); 2,497(38,1); 2,492(18,1); 2,470(2,2); 2,151(1,4); 2,024(13,5); 1,995(8,6); 1,144(0,9); 1,125(3,5); 1,106(7,9); 1,091(5,2); 1,088(3,9); 1,073(1,9); 0,008(0,7); 0,000(25,9); -0,009(0,8) 3,670 (16.0); 3.581 (10.7); 3,169 (0.8); 2,947 (9.8); 2,924 (1.7); 2,915 (15.8); 2,895 (1.8); 2,524 (1.6); 2,519 (1.6); 2,510 (18.4); 2,506 (40.5); 2,501 (54.4); 2,497 (38.1); 2,492 (18.1); 2,470 (2.2); 2,151 (1.4); 2,024 (13.5); 1,995 (8.6); 1,144 (0.9); 1.125 (3.5); 1,106 (7.9); 1,091 (5.2); 1,088 (3.9); 1,073 (1.9); 0.008 (0.7); 0,000 (25.9); -0.009 (0.8)
Verbindung Nr.2863, Lösungsmittel [DMSO], 400 MHz Compound No. 2863, solvent [DMSO], 400 MHz
12,255(0,6); 9,859(0,9); 8,118(5,3); 3,454(10,3); 3,445(5,8); 3,443(5,7); 3,439(4,7); 3,431 (6,5); 3,429(6,1 ); 3,420(3,9); 3,411 (1 ,0); 3,408(1 ,1 ); 3,401 (0,7); 3,265(31 ,1 ); 2,591(0,9); 2,572(2,9); 2,554(3,0); 2,535(1,0); 2,524(0,7); 2,519(1,0); 2,511(11,1); 2,506(23,4); 2,502(32,3); 2,497(22,6); 2,492(10,1); 2,088(16,0); 1,131(3,7); 1,113(8,8); 1,094(3,5); 0,008(0,5); 0,000(15,5) Verbindung Nr.3853, Lösungsmittel [DMSO], 400 MHz 12.255 (0.6); 9,859 (0.9); 8,118 (5.3); 3,454 (10.3); 3,445 (5.8); 3,443 (5.7); 3,439 (4.7); 3,431 (6.5); 3,429 (6.1); 3,420 (3.9); 3,411 (1, 0); 3.408 (1, 1); 3.401 (0.7); 3,265 (31, 1); 2,591 (0.9); 2,572 (2.9); 2,554 (3.0); 2,535 (1.0); 2,524 (0.7); 2,519 (1.0); 2,511 (11.1); 2,506 (23.4); 2,502 (32.3); 2,497 (22.6); 2,492 (10.1); 2,088 (16.0); 1,131 (3.7); 1,113 (8.8); 1,094 (3.5); 0.008 (0.5); 0.000 (15.5) Compound No. 3853, Solvent [DMSO], 400 MHz
12,758(1,0); 9,642(1,7); 9,629(1,0); 8,401(15,5); 3,476(0,6); 3,471(0,9); 3,466(1,1); 3,458(3,3); 3,446(4,4); 3,444(4,0); 3,432(8,5); 3,423(5,8); 3,414(1,1); 3,410(1,5); 3,404(0,8); 3,307(29,5); 3,264(56,4); 2,676(3,1 ); 2,660(3,1 ); 2,657(3,6); 2,652(2,9); 2,637(3,2); 2,525(0,8); 2,520(1,2); 2,511(14,0); 2,507(29,4); 2,502(40,5); 2,497(28,4); 2,493(12,9); 1,618(1,7); 1,599(2,9); 1,580(2,9); 1,561(1,7); 0,949(7,2); 0,931(16,0); 0,912(6,5); 0,008(0,7); 0,000(21,0); -0,009(0,6) Verbindung Nr.3810, Lösungsmittel [DMSO], 400 MHz  12.758 (1.0); 9,642 (1.7); 9,629 (1.0); 8.401 (15.5); 3,476 (0.6); 3,471 (0.9); 3,466 (1.1); 3,458 (3.3); 3,446 (4.4); 3,444 (4.0); 3,432 (8.5); 3,423 (5.8); 3,414 (1.1); 3,410 (1.5); 3,404 (0.8); 3.307 (29.5); 3,264 (56.4); 2,676 (3.1); 2,660 (3.1); 2,657 (3.6); 2,652 (2.9); 2,637 (3.2); 2,525 (0.8); 2,520 (1.2); 2,511 (14.0); 2.507 (29.4); 2,502 (40.5); 2,497 (28.4); 2,493 (12.9); 1.618 (1.7); 1,599 (2.9); 1,580 (2.9); 1,561 (1.7); 0.949 (7.2); 0.931 (16.0); 0.912 (6.5); 0.008 (0.7); 0,000 (21.0); -0.009 (0.6) Compound No. 3810, solvent [DMSO], 400 MHz
12,770(1,1); 9,586(0,7); 9,572(1,2); 9,558(0,7); 8,396(11,6); 3,307(28,4); 3,270(1,8); 12.770 (1.1); 9,586 (0.7); 9,572 (1.2); 9.558 (0.7); 8,396 (11.6); 3.307 (28.4); 3,270 (1.8);
3,252(3,4); 3,237(3,4); 3,220(1,8); 2,673(2,3); 2,658(2,2); 2,654(2,7); 2,650(2,1);3,252 (3.4); 3.237 (3.4); 3,220 (1.8); 2,673 (2.3); 2,658 (2.2); 2,654 (2.7); 2,650 (2.1);
2,635(2,4); 2,525(0,7); 2,520(0,9); 2,511(11,7); 2,507(25,1); 2,502(34,9); 2,497(24,3);2,635 (2.4); 2,525 (0.7); 2,520 (0.9); 2,511 (11.7); 2,507 (25.1); 2,502 (34.9); 2,497 (24.3);
2,493(10,9); 1,617(1,3); 1,598(2,1); 1,579(2,2); 1,560(1,3); 1,542(0,8); 1,524(2,0); 1,505(3,7); 1,488(3,7); 1,470(2,2); 0,949(5,6); 0,931(12,7); 0,912(5,1); 0,900(7,5);2,493 (10.9); 1,617 (1.3); 1,598 (2.1); 1,579 (2.2); 1,560 (1.3); 1.542 (0.8); 1.524 (2.0); 1,505 (3.7); 1,488 (3.7); 1,470 (2.2); 0.949 (5.6); 0.931 (12.7); 0.912 (5.1); 0.900 (7.5);
0,882(16,0); 0,863(6,5); 0,008(0,6); 0,000(18,0); -0,009(0,5) 0.882 (16.0); 0.863 (6.5); 0.008 (0.6); 0,000 (18.0); -0.009 (0.5)
Verbindung Nr.3830, Lösungsmittel [DMSO], 400 MHz Compound No. 3830, solvent [DMSO], 400 MHz
9,531(0,7); 8,392(6,5); 3,326(1,0); 3,308(19,0); 3,294(1,4); 3,291(1,4); 3,275(0,8); 2,672(1 ,1 ); 2,656(1 ,1 ); 2,653(1 ,3); 2,648(1 ,0); 2,633(1 ,1 ); 2,519(0,6); 2,511 (8,0); 2,506(17,4); 2,502(24,3); 2,497(17,0); 2,492(7,7); 1,615(0,6); 1,607(0,7); 1,596(1,1); 1,591(1,2); 1,577(1,2); 1,574(1,3); 1,558(0,9); 1,410(0,9); 1,392(1,8); 1,374(1,8); 1,356(0,7); 0,948(2,6); 0,930(5,8); 0,911(2,4); 0,899(16,0); 0,882(15,3); 0,863(0,6); 0,846(0,5); 0,000(5,0)  9.531 (0.7); 8,392 (6.5); 3,326 (1.0); 3,308 (19.0); 3,294 (1.4); 3,291 (1.4); 3,275 (0.8); 2,672 (1, 1); 2,656 (1, 1); 2,653 (1, 3); 2,648 (1, 0); 2,633 (1, 1); 2,519 (0.6); 2,511 (8.0); 2,506 (17.4); 2,502 (24.3); 2,497 (17.0); 2,492 (7.7); 1,615 (0.6); 1,607 (0.7); 1,596 (1.1); 1,591 (1.2); 1,577 (1.2); 1.574 (1.3); 1.558 (0.9); 1,410 (0.9); 1,392 (1.8); 1,374 (1.8); 1.356 (0.7); 0.948 (2.6); 0.930 (5.8); 0.911 (2.4); 0.899 (16.0); 0.882 (15.3); 0.863 (0.6); 0.846 (0.5); 0.000 (5.0)
Verbindung Nr.3809, Lösungsmittel [DMSO], 400 MHz Compound No. 3809, solvent [DMSO], 400 MHz
12,765(0,6); 9,524(0,7); 9,509(1,2); 9,496(0,6); 8,396(13,3); 3,332(1,1); 3,309(27,2); 3,300(4,0); 3,296(3,6); 3,282(3,3); 3,279(1,4); 3,264(1,0); 2,671(2,5); 2,652(2,7); 2,648(2,1); 2,633(2,4); 2,525(0,6); 2,520(1,0); 2,511(13,2); 2,507(28,3); 2,502(39,2); 2,498(27,3); 2,493(12,3); 1,616(1,2); 1,597(2,1); 1,578(2,2); 1,559(1,3); 1,118(7,1); 1,100(16,0); 1,082(6,9); 0,947(5,4); 0,929(12,1); 0,910(4,9); 0,000(3,1) Verbindung Nr.3589, Lösungsmittel [DMSO], 400 MHz 12.765 (0.6); 9.524 (0.7); 9,509 (1.2); 9.496 (0.6); 8,396 (13.3); 3,332 (1.1); 3,309 (27.2); 3,300 (4.0); 3,296 (3.6); 3,282 (3.3); 3,279 (1.4); 3,264 (1.0); 2,671 (2.5); 2,652 (2.7); 2,648 (2.1); 2,633 (2.4); 2,525 (0.6); 2,520 (1.0); 2,511 (13.2); 2,507 (28.3); 2,502 (39.2); 2,498 (27.3); 2,493 (12.3); 1,616 (1.2); 1,597 (2.1); 1,578 (2.2); 1.559 (1.3); 1,118 (7.1); 1,100 (16.0); 1,082 (6.9); 0.947 (5.4); 0.929 (12.1); 0.910 (4.9); 0.000 (3.1) Compound No. 3589, solvent [DMSO], 400 MHz
12,823(0,7); 9,538(0,7); 8,165(11,5); 3,444(2,6); 3,342(1,0); 3,328(1,2); 3,324(3,1); 3,310(3,3); 3,306(3,3); 3,292(3,1); 3,288(1,2); 3,274(1,0); 2,667(2,4); 2,648(2,8);  12.823 (0.7) 9.538 (0.7); 8,165 (11.5); 3,444 (2.6); 3,342 (1.0); 3,328 (1.2); 3,324 (3.1); 3,310 (3.3); 3,306 (3.3); 3,292 (3.1); 3,288 (1.2); 3,274 (1.0); 2,667 (2.4); 2,648 (2.8);
2,645(2,2); 2,629(2,5); 2,524(0,7); 2,519(1,0); 2,511(16,3); 2,506(35,9); 2,501(50,4); 2,497(35,0); 2,492(15,7); 1 ,646(1 ,3); 1 ,627(2,3); 1 ,608(2,3); 1 ,589(1 ,4); 1 ,125(7,0); 1,107(16,0); 1,089(6,9); 0,930(5,6); 0,912(12,5); 0,893(5,0); 0,000(13,0) 2,645 (2.2); 2,629 (2.5); 2,524 (0.7); 2,519 (1.0); 2,511 (16.3); 2,506 (35.9); 2,501 (50.4); 2,497 (35.0); 2,492 (15.7); 1, 646 (1, 3); 1, 627 (2, 3); 1, 608 (2,3); 1, 589 (1, 4); 1, 125 (7.0); 1,107 (16.0); 1,089 (6.9); 0.930 (5.6); 0.912 (12.5); 0,893 (5.0); 0.000 (13.0)
Verbindung Nr.3585, Lösungsmittel [DMSO], 400 MHz Compound No. 3585, solvent [DMSO], 400 MHz
7,458(3,5); 3,443(3,5); 3,392(1,6); 3,374(3,9); 3,357(3,8); 3,339(1,3); 3,169(1,3);  7,458 (3.5); 3,443 (3.5); 3,392 (1.6); 3,374 (3.9); 3,357 (3.8); 3,339 (1.3); 3,169 (1.3);
3,151(3,5); 3,133(3,5); 3,115(1,1); 2,591(1,7); 2,573(2,6); 2,553(1,9); 2,523(1,3); 3,151 (3.5); 3,133 (3.5); 3,115 (1.1); 2,591 (1.7); 2,573 (2.6); 2,553 (1.9); 2,523 (1.3);
2,518(1,9); 2,510(23,6); 2,505(51,0); 2,501(71,4); 2,496(49,5); 2,491(21,9); 1,635(1,4); 1,616(2,5); 1,597(2,5); 1,578(1,4); 1,108(4,4); 1,090(9,7); 1,073(4,4); 1,051(4,2);  2,518 (1.9); 2,510 (23.6); 2,505 (51.0); 2,501 (71.4); 2,496 (49.5); 2,491 (21.9); 1,635 (1.4); 1,616 (2.5); 1,597 (2.5); 1,578 (1.4); 1,108 (4.4); 1,090 (9.7); 1,073 (4.4); 1,051 (4.2);
1,034(9,0); 1,016(3,9); 0,930(7,2); 0,911(16,0); 0,893(6,4); 0,008(0,7); 0,002(0,9); 0,000(23,3); -0,009(0,6) 1,034 (9.0); 1.016 (3.9); 0.930 (7.2); 0.911 (16.0); 0,893 (6.4); 0.008 (0.7); 0.002 (0.9); 0,000 (23.3); -0.009 (0.6)
Verbindung Nr.3590, Lösungsmittel [DMSO], 400 MHz Compound No. 3590, solvent [DMSO], 400 MHz
12,818(1,0); 9,598(1,0); 8,165(10,3); 3,304(53,6); 3,278(2,0); 3,261(3,5); 3,246(3,5); 3,229(2,0); 2,668(2,7); 2,650(3,1); 2,630(2,6); 2,523(1,8); 2,518(2,6); 2,510(37,1); 2,505(80,3); 2,501(112,0); 2,496(78,0); 2,491(35,0); 2,327(0,6); 1,647(1,4); 1,628(2,4); 1 ,609(2,5); 1 ,591 (1 ,4); 1 ,531 (2,0); 1 ,513(3,7); 1 ,495(3,8); 1 ,477(2,1 ); 0,932(6,0);  12.818 (1.0); 9,598 (1.0); 8,165 (10.3); 3,304 (53.6); 3,278 (2.0); 3,261 (3.5); 3,246 (3.5); 3,229 (2.0); 2,668 (2.7); 2,650 (3.1); 2,630 (2.6); 2,523 (1.8); 2,518 (2.6); 2,510 (37.1); 2,505 (80.3); 2.501 (112.0); 2,496 (78.0); 2,491 (35.0); 2,327 (0.6); 1,647 (1.4); 1,628 (2.4); 1, 609 (2.5); 1, 591 (1, 4); 1, 531 (2.0); 1, 513 (3,7); 1, 495 (3,8); 1, 477 (2,1); 0.932 (6.0);
0,913(13,5); 0,905(7,9); 0,895(5,8); 0,886(16,0); 0,868(6,6); 0,008(0,9); 0,000(30,1); - 0,009(0,9)  0.913 (13.5); 0.905 (7.9); 0.895 (5.8); 0.886 (16.0); 0.868 (6.6); 0.008 (0.9); 0,000 (30.1); - 0.009 (0.9)
Verbindung Nr.3610, Lösungsmittel [DMSO], 400 MHz Compound No. 3610, solvent [DMSO], 400 MHz
12,807(0,5); 9,562(0,5); 8,161(4,7); 3,335(0,8); 3,317(1,5); 3,306(22,0); 3,285(0,8); 2,666(1,2); 2,648(1,4); 2,629(1,1); 2,523(0,7); 2,519(1,0); 2,510(13,6); 2,506(29,1); 2,501(40,2); 2,496(27,8); 2,492(12,4); 1,645(0,7); 1,627(1,2); 1,612(1,2); 1,607(1,2); 1,595(0,9); 1,589(0,7); 1,579(0,7); 1,417(0,9); 1,400(1,8); 1,381(1,8); 1,364(0,7); 12.807 (0.5); 9,562 (0.5); 8,161 (4.7); 3,335 (0.8); 3,317 (1.5); 3,306 (22.0); 3,285 (0.8); 2,666 (1.2); 2,648 (1.4); 2,629 (1.1); 2,523 (0.7); 2,519 (1.0); 2,510 (13.6); 2,506 (29.1); 2,501 (40.2); 2,496 (27.8); 2,492 (12.4); 1,645 (0.7); 1,627 (1.2); 1,612 (1.2); 1,607 (1.2); 1,595 (0.9); 1,589 (0.7); 1,579 (0.7); 1,417 (0.9); 1,400 (1.8); 1,381 (1.8); 1.364 (0.7);
0,931(2,8); 0,913(6,3); 0,902(16,0); 0,894(3,1); 0,886(15,1); 0,000(11,3) 0.931 (2.8); 0.913 (6.3); 0.902 (16.0); 0.894 (3.1); 0.886 (15.1); 0.000 (11.3)
Verbindung Nr.3681, Lösungsmittel [DMSO], 400 MHz Compound No. 3681, Solvent [DMSO], 400 MHz
7,407(3,6); 7,381(3,3); 5,161(1,5); 5,150(1,4); 4,385(0,7); 4,350(0,7); 4,320(1,1);  7,407 (3.6); 7,381 (3.3); 5,161 (1.5); 5,150 (1.4); 4,385 (0.7); 4,350 (0.7); 4,320 (1.1);
4,308(1,0); 4,186(1,9); 4,168(5,8); 4,150(6,1); 4,139(1,9); 4,133(2,2); 4,121(2,2); 4,308 (1.0); 4,186 (1.9); 4,168 (5.8); 4,150 (6.1); 4,139 (1.9); 4,133 (2.2); 4,121 (2.2);
4,103(2,0); 4,086(1,5); 4,076(0,7); 4,068(0,5); 4,059(0,7); 3,579(2,1); 3,410(0,9); 3,377(1,1); 3,154(0,6); 3,146(0,6); 3,122(1,0); 3,115(1,0); 3,090(0,6); 2,736(0,7); 4,103 (2.0); 4,086 (1.5); 4,076 (0.7); 4,068 (0.5); 4,059 (0.7); 3.579 (2.1) 3,410 (0.9); 3,377 (1.1); 3,154 (0.6); 3,146 (0.6); 3,122 (1.0); 3,115 (1.0); 3,090 (0.6) 2,736 (0.7);
2,670(0,5); 2,606(1,8); 2,588(3,2); 2,568(3,0); 2,552(1,2); 2,524(1,5); 2,519(2,2); 2,670 (0.5); 2,606 (1.8); 2,588 (3.2); 2,568 (3.0); 2,552 (1.2); 2,524 (1.5); 2,519 (2.2);
2,510(26,4); 2,506(56,6); 2,501(79,0); 2,496(55,0); 2,492(24,3); 2,155(0,9); 2,120(0,9); 2,062(0,6); 2,027(0,7); 1,687(2,6); 1,675(2,1); 1,646(3,4); 1,626(3,1); 1,611(3,3); 2,510 (26.4); 2,506 (56.6); 2,501 (79.0); 2,496 (55.0); 2,492 (24.3); 2,155 (0.9); 2,120 (0.9); 2,062 (0.6); 2,027 (0.7); 1,687 (2.6); 1.675 (2.1); 1,646 (3.4); 1,626 (3.1); 1,611 (3.3);
1 ,607(3,3); 1 ,593(2,5); 1 ,575(1 ,6); 1 ,557(0,7); 1 ,537(1 ,2); 1 ,484(0,7); 1 ,452(0,6); 1, 607 (3,3); 1, 593 (2.5); 1, 575 (1, 6); 1, 557 (0.7); 1, 537 (1, 2); 1, 484 (0.7); 1, 452 (0.6);
1,329(0,9); 1,301(1,0); 1,259(1,1); 1,243(7,6); 1,225(16,0); 1,208(7,4); 1,190(4,6); 1,172(9,2); 1,154(4,3); 0,939(5,5); 0,928(4,2); 0,920(11,9); 0,910(7,9); 0,902(5,5); 0,891(3,4); 0,008(0,7); 0,000(26,7); -0,009(0,8) Verbindung Nr.3633, Lösungsmittel [DMSO], 400 MHz 1,329 (0.9); 1,301 (1.0); 1,259 (1.1); 1,243 (7.6); 1,225 (16.0); 1.208 (7.4); 1,190 (4.6); 1,172 (9.2); 1,154 (4.3); 0.939 (5.5); 0.928 (4.2); 0.920 (11.9); 0.910 (7.9); 0.902 (5.5); 0.891 (3.4); 0.008 (0.7); 0,000 (26.7); -0.009 (0.8) Compound No. 3633, solvent [DMSO], 400 MHz
12,816(1,3); 9,670(1,3); 8,172(14,3); 3,486(0,6); 3,480(0,8); 3,475(1,0); 3,468(2,9); 12,816 (1.3); 9,670 (1.3); 8,172 (14.3); 3,486 (0.6); 3,480 (0.8); 3,475 (1.0); 3,468 (2.9);
3,456(3,9); 3,444(5,0); 3,440(7,1); 3,429(5,2); 3,422(1,0); 3,418(1,4); 3,411(0,8); 3,456 (3.9); 3,444 (5.0); 3,440 (7.1); 3,429 (5.2); 3,422 (1.0); 3,418 (1.4); 3,411 (0.8);
3,326(13,5); 3,306(0,8); 3,267(57,4); 2,671(3,1); 2,652(3,7); 2,633(3,0); 2,524(1,0); 3,326 (13.5); 3,306 (0.8); 3,267 (57.4); 2,671 (3.1); 2,652 (3.7); 2,633 (3.0); 2,524 (1.0);
2,519(1,6); 2,511(20,4); 2,506(44,1); 2,501(61,1); 2,497(42,4); 2,492(19,0); 1,648(1,7); 1 ,629(2,9); 1 ,610(3,0); 1 ,591 (1 ,7); 0,932(7,2); 0,914(16,0); 0,895(6,4); 0,008(0,6);2,519 (1.6); 2,511 (20.4); 2,506 (44.1); 2,501 (61.1); 2,497 (42.4); 2,492 (19.0); 1,648 (1.7); 1, 629 (2,9); 1, 610 (3.0); 1, 591 (1, 7); 0.932 (7.2); 0.914 (16.0); 0.895 (6.4); 0.008 (0.6);
0,000(18,0); -0,009(0,5) 0,000 (18.0); -0.009 (0.5)
Verbindung Nr.3901, Lösungsmittel [DMSO], 400 MHz Compound No. 3901, solvent [DMSO], 400 MHz
12,273(1,4); 7,540(4,0); 5,147(2,1); 5,137(1,9); 4,370(0,9); 4,336(1,0); 4,297(1,5); 4,288(1,4); 4,184(2,5); 4,167(7,4); 4,149(7,6); 4,141(2,3); 4,131(2,7); 4,123(2,0);  12.273 (1.4); 7,540 (4.0); 5,147 (2.1); 5,137 (1.9); 4,370 (0.9); 4,336 (1.0); 4,297 (1.5); 4,288 (1.4); 4,184 (2.5); 4,167 (7.4); 4,149 (7.6); 4,141 (2.3); 4,131 (2.7); 4,123 (2.0);
4,100(1,7); 4,083(1,6); 4,073(0,8); 4,065(0,6); 4,056(0,7); 3,422(7,0); 3,368(1,9);  4,100 (1.7); 4,083 (1.6); 4,073 (0.8); 4,065 (0.6); 4,056 (0.7); 3,422 (7.0); 3,368 (1.9);
3,124(0,8); 3,099(1,3); 3,068(0,7); 2,754(0,6); 2,721(0,9); 2,692(0,5); 2,670(0,6);  3,124 (0.8); 3,099 (1.3); 3,068 (0.7); 2,754 (0.6); 2,721 (0.9); 2,692 (0.5); 2,670 (0.6);
2,611(2,2); 2,593(4,5); 2,574(4,3); 2,555(1,9); 2,510(31,2); 2,506(61,5); 2,501(82,5); 2,611 (2.2); 2,593 (4.5); 2,574 (4.3); 2,555 (1.9); 2,510 (31.2); 2,506 (61.5); 2,501 (82.5);
2,497(60,3); 2,492(29,5); 2,328(0,5); 2,151(1,2); 2,116(1,2); 2,056(0,8); 2,024(1,0); 1 ,680(3,6); 1 ,652(4,0); 1 ,613(2,4); 1 ,595(3,5); 1 ,576(4,4); 1 ,562(3,5); 1 ,543(2,6); 2,497 (60.3); 2,492 (29.5); 2,328 (0.5); 2,151 (1.2); 2,116 (1.2); 2,056 (0.8); 2,024 (1.0); 1, 680 (3,6); 1, 652 (4.0); 1, 613 (2,4); 1, 595 (3.5); 1, 576 (4,4); 1, 562 (3, 5); 1, 543 (2.6);
1,478(1,0); 1,447(0,9); 1,357(0,6); 1,323(1,2); 1,295(1,4); 1,243(8,4); 1,226(16,0); 1,478 (1.0); 1,447 (0.9); 1,357 (0.6); 1.323 (1.2); 1,295 (1.4); 1,243 (8.4); 1,226 (16.0);
1,208(8,2); 1,199(5,5); 1,181(9,7); 1,164(4,6); 0,952(6,0); 0,942(5,4); 0,934(12,6);1,208 (8.2); 1,199 (5.5); 1,181 (9.7); 1,164 (4.6); 0,952 (6.0); 0.942 (5.4); 0.934 (12.6);
0,924(9,1); 0,916(6,2); 0,905(3,8); 0,008(0,8); 0,000(16,6); -0,008(0,8) Verbindung Nr.3805, Lösungsmittel [DMSO], 400 MHz 0.924 (9.1); 0.916 (6.2); 0.905 (3.8); 0.008 (0.8); 0,000 (16.6); -0.008 (0.8) Compound No. 3805, solvent [DMSO], 400 MHz
12,210(1,2); 7,572(2,9); 3,380(2,8); 3,356(15,4); 3,328(2,3); 3,169(0,6); 3,159(1,5); 3,142(4,4); 3,124(4,5); 3,106(1,5); 2,670(0,6); 2,598(1,9); 2,579(3,2); 2,559(2,2);  12.210 (1.2); 7,572 (2.9); 3,380 (2.8); 3,356 (15.4); 3,328 (2.3); 3,169 (0.6); 3,159 (1.5); 3.142 (4.4); 3,124 (4.5); 3,106 (1.5); 2,670 (0.6); 2,598 (1.9); 2,579 (3.2); 2,559 (2.2);
2,523(2,8); 2,509(36,4); 2,505(72,2); 2,500(96,4); 2,496(68,3); 2,491(31,7); 2,327(0,6); 1,604(1,6); 1,585(2,9); 1,566(2,9); 1,547(1,7); 1,101(5,6); 1,083(11,8); 1,066(5,6); 1,046(5,4); 1,029(11,1); 1,011(5,0); 0,944(7,5); 0,926(16,0); 0,908(6,7); 0,008(1,0); 0,000(21,8); -0,009(0,8) 2,523 (2.8); 2,509 (36.4); 2,505 (72.2); 2,500 (96.4); 2,496 (68.3); 2,491 (31.7); 2,327 (0.6); 1,604 (1.6); 1.585 (2.9); 1,566 (2.9); 1,547 (1.7); 1,101 (5.6); 1.083 (11.8); 1,066 (5.6); 1,046 (5.4); 1,029 (11.1); 1,011 (5.0); 0.944 (7.5); 0.926 (16.0); 0.908 (6.7); 0.008 (1.0); 0,000 (21.8); -0.009 (0.8)
Verbindung Nr.3700, Lösungsmittel [DMSO], 400 MHz Compound No. 3700, solvent [DMSO], 400 MHz
12,835(1 ,1 ); 9,579(1 ,1 ); 8,255(9,4); 3,304(81 ,1 ); 3,276(1 ,9); 3,259(3,5); 3,244(3,3); 3,227(1,9); 2,672(2,6); 2,653(2,8); 2,634(2,3); 2,523(2,6); 2,518(3,6); 2,510(42,5); 2,505(90,5); 2,501(125,2); 2,496(86,1); 2,491(38,0); 2,327(0,7); 2,323(0,5); 1,642(1,3); 1,623(2,3); 1,604(2,3); 1,585(1,4); 1,529(2,0); 1,511(3,6); 1,493(3,6); 1,475(2,1); 12,835 (1, 1); 9.589 (1, 1); 8.255 (9.4); 3,304 (81, 1); 3,276 (1, 9); 3,259 (3.5); 3,244 (3.3); 3,227 (1.9); 2,672 (2.6); 2,653 (2.8); 2,634 (2.3); 2,523 (2.6); 2,518 (3.6); 2,510 (42.5); 2,505 (90.5); 2.501 (125.2); 2,496 (86.1); 2,491 (38.0); 2.327 (0.7) 2,323 (0.5); 1,642 (1.3); 1,623 (2.3); 1,604 (2.3); 1.585 (1.4) 1,529 (2.0); 1.511 (3.6); 1.493 (3.6); 1.475 (2.1);
0,939(5,9); 0,920(13,2); 0,903(10,8); 0,885(16,0); 0,866(6,5); 0,000(14,6) 0.939 (5.9); 0.920 (13.2); 0.903 (10.8); 0.885 (16.0); 0.866 (6.5); 0.000 (14.6)
Verbindung Nr.3743, Lösungsmittel [DMSO], 400 MHz Compound No. 3743, solvent [DMSO], 400 MHz
12,828(1,3); 9,651(1,3); 8,261(13,8); 3,483(0,6); 3,477(0,9); 3,473(1,0); 3,466(2,9); 3,453(3,8); 3,437(7,1); 3,427(5,2); 3,415(1,4); 3,409(0,7); 3,304(59,5); 3,266(57,0); 2,674(3,3); 2,656(3,5); 2,636(3,0); 2,523(2,2); 2,518(3,2); 2,510(44,0); 2,505(95,3); 2,501 (132,9); 2,496(91 ,7); 2,491 (40,6); 2,332(0,5); 2,327(0,8); 2,323(0,5); 1 ,643(1 ,6); 1,624(2,8); 1,605(2,9); 1,586(1,7); 0,939(7,1); 0,921(16,0); 0,902(6,4); 0,000(16,5); - 0,008(0,5)  12,828 (1.3); 9,651 (1.3); 8,261 (13.8); 3,483 (0.6); 3,477 (0.9); 3,473 (1.0); 3,466 (2.9); 3,453 (3.8); 3,437 (7.1); 3,427 (5.2); 3,415 (1.4); 3,409 (0.7); 3,304 (59.5); 3.266 (57.0); 2,674 (3.3); 2,656 (3.5); 2,636 (3.0); 2,523 (2.2); 2,518 (3.2); 2,510 (44.0); 2,505 (95.3); 2,501 (132.9); 2,496 (91, 7); 2,491 (40.6); 2,332 (0.5); 2,327 (0.8); 2,323 (0.5); 1, 643 (1, 6); 1,624 (2.8); 1,605 (2.9); 1.586 (1.7); 0.939 (7.1); 0.921 (16.0); 0.902 (6.4); 0,000 (16.5); - 0.008 (0.5)
Verbindung Nr.3791, Lösungsmittel [DMSO], 400 MHz Compound No. 3791, solvent [DMSO], 400 MHz
12,294(0,8); 7,467(1 ,8); 7,447(1 ,8); 5,156(1 ,5); 4,374(0,7); 4,344(0,8); 4,316(1 ,1 );12,294 (0.8); 7,467 (1, 8); 7,447 (1, 8); 5,156 (1, 5); 4,374 (0.7); 4,344 (0.8); 4,316 (1, 1);
4,185(2,3); 4,167(7,2); 4,150(7,3); 4,140(2,1); 4,132(2,5); 4,122(2,0); 4,102(1,6); 4.185 (2.3); 4,167 (7.2); 4,150 (7.3); 4,140 (2.1); 4,132 (2.5); 4,122 (2.0); 4,102 (1.6);
4,084(1,5); 4,075(0,7); 4,057(0,8); 3,389(21,6); 3,169(0,7); 3,141(0,7); 3,109(1,0); 4,084 (1.5); 4.075 (0.7); 4,057 (0.8); 3,389 (21.6); 3,169 (0.7); 3,141 (0.7); 3,109 (1.0);
3,084(0,5); 2,731(0,7); 2,674(1,0); 2,669(1,3); 2,665(0,9); 2,590(3,0); 2,571(2,8); 3,084 (0.5); 2,731 (0.7); 2,674 (1.0); 2,669 (1.3); 2,665 (0.9); 2,590 (3.0); 2,571 (2.8);
2,523(4,3); 2,518(5,8); 2,510(77,0); 2,505(166,2); 2,500(231,0); 2,496(158,8);  2,523 (4.3); 2,518 (5.8); 2,510 (77.0); 2.505 (166.2); 2,500 (231.0); 2.496 (158.8);
2,491(69,9); 2,332(1,0); 2,327(1,2); 2,322(1,0); 2,153(0,9); 2,122(0,9); 2,085(1,6);2,491 (69.9); 2,332 (1.0); 2,327 (1.2); 2,322 (1.0); 2,153 (0.9); 2,122 (0.9); 2,085 (1.6);
2,058(0,7); 2,026(0,8); 1,685(2,6); 1,658(3,1); 1,620(2,8); 1,605(3,0); 1,586(2,2); 2,058 (0.7); 2,026 (0.8); 1,685 (2.6); 1,658 (3.1); 1,620 (2.8); 1,605 (3.0); 1.586 (2.2);
1,539(1,2); 1,483(0,7); 1,449(0,7); 1,364(0,5); 1,328(0,9); 1,299(1,1); 1,242(7,8);  1.539 (1.2); 1,483 (0.7); 1,449 (0.7); 1.364 (0.5); 1.328 (0.9); 1,299 (1.1); 1,242 (7.8);
1,225(16,0); 1,207(7,3); 1,193(4,7); 1,175(9,1); 1,157(4,2); 0,944(5,2); 0,934(4,2); 1,225 (16.0); 1,207 (7.3); 1.193 (4.7); 1.175 (9.1); 1,157 (4.2); 0.944 (5.2); 0.934 (4.2);
0,926(11,1); 0,916(7,6); 0,908(5,0); 0,897(3,2); 0,008(1,0); 0,000(34,4); -0,009(0,9) 0.926 (11.1); 0.916 (7.6); 0.908 (5.0); 0.897 (3.2); 0.008 (1.0); 0,000 (34.4); -0.009 (0.9)
Verbindung Nr.3721, Lösungsmittel [DMSO], 400 MHz Compound No. 3721, solvent [DMSO], 400 MHz
9,541(0,5); 8,251(3,9); 3,333(0,8); 3,304(51,6); 3,283(0,8); 2,670(1,3); 2,651(1,2); 2,632(1 ,0); 2,523(1 ,3); 2,518(1 ,9); 2,510(26,6); 2,505(57,1 ); 2,500(79,1 ); 2,496(54,7); 2,491(24,5); 1,641(0,6); 1,621(1,0); 1,610(0,7); 1,602(1,1); 1,594(0,8); 1,584(0,6); 1,577(0,7); 1,415(0,8); 1,398(1,5); 1,379(1,5); 1,362(0,6); 0,938(2,4); 0,920(5,4); 9,541 (0.5); 8,251 (3.9); 3.333 (0.8); 3,304 (51.6); 3,283 (0.8); 2,670 (1.3); 2,651 (1.2); 2,632 (1, 0); 2.523 (1, 3); 2.518 (1, 9); 2,510 (26.6); 2,505 (57.1); 2,500 (79.1); 2,496 (54.7); 2,491 (24.5); 1.641 (0.6); 1,621 (1.0); 1,610 (0.7); 1.602 (1.1); 1,594 (0.8); 1,584 (0.6); 1,577 (0.7); 1.415 (0.8); 1,398 (1.5); 1,379 (1.5); 1,362 (0.6); 0.938 (2.4); 0.920 (5.4);
0,901(16,0); 0,885(13,1); 0,000(9,8) 0.901 (16.0); 0.885 (13.1); 0.000 (9.8)
Verbindung Nr.3697, Lösungsmittel [DMSO], 400 MHz Compound No. 3697, Solvent [DMSO], 400 MHz
12,358(0,7); 7,508(1,3); 7,468(1,2); 4,172(4,2); 4,072(3,0); 3,675(16,0); 3,603(11,3); 3,317(261,6); 2,949(7,1); 2,917(10,1); 2,678(1,1); 2,674(2,3); 2,669(3,3); 2,664(2,4); 2,660(1,1); 2,613(0,8); 2,591(1,6); 2,572(1,5); 2,550(1,7); 2,545(1,5); 2,540(1,2); 12,358 (0.7); 7,508 (1.3); 7,468 (1.2); 4,172 (4.2); 4,072 (3.0); 3,675 (16.0); 3,603 (11.3); 3.317 (261.6); 2.949 (7.1); 2,917 (10.1); 2,678 (1.1); 2,674 (2.3); 2,669 (3.3); 2,664 (2.4); 2,660 (1.1); 2,613 (0.8); 2,591 (1.6); 2,572 (1.5); 2,550 (1.7); 2,545 (1.5); 2,540 (1.2);
2,523(9,2); 2,518(13,5); 2,509(184,5); 2,505(397,6); 2,500(556,4); 2,495(388,7); 2,523 (9.2); 2,518 (13.5); 2.509 (184.5); 2.505 (397.6); 2,500 (556.4); 2.495 (388.7);
2,491(173,7); 2,467(1,7); 2,463(1,4); 2,435(0,6); 2,400(0,6); 2,336(1,2); 2,331(2,4); 2,327(3,4); 2,322(2,3); 2,071 (1 ,4); 1 ,621 (1 ,4); 1 ,601 (1 ,7); 1 ,584(1 ,3); 0,942(2,8); 2.491 (173.7); 2,467 (1.7); 2,463 (1.4); 2,435 (0.6); 2,400 (0.6); 2,336 (1.2); 2.331 (2.4); 2,327 (3.4); 2,322 (2.3); 2.071 (1, 4); 1, 621 (1, 4); 1, 601 (1, 7); 1, 584 (1, 3); 0.942 (2.8);
0,924(6,8); 0,907(5,2); 0,889(1,8); 0,008(2,0); 0,000(65,6); -0,009(2,0) 0.924 (6.8); 0.907 (5.2); 0.889 (1.8); 0.008 (2.0); 0,000 (65.6); -0.009 (2.0)
Verbindung Nr.3695, Lösungsmittel [DMSO], 400 MHz Compound No. 3695, solvent [DMSO], 400 MHz
7,519(4,0); 3,628(1,7); 3,389(1,3); 3,371(3,9); 3,354(4,0); 3,336(1,3); 3,169(1,3);  7,519 (4.0); 3.628 (1.7); 3,389 (1.3); 3,371 (3.9); 3.354 (4.0); 3,336 (1.3); 3,169 (1.3);
3,150(3,7); 3,132(3,7); 3,114(1,2); 2,597(1,9); 2,578(2,8); 2,559(2,1); 2,523(1,2); 3,150 (3.7); 3,132 (3.7); 3,114 (1.2); 2,597 (1.9); 2,578 (2.8); 2,559 (2.1); 2,523 (1.2);
2,519(1,7); 2,510(24,7); 2,505(53,9); 2,501(75,3); 2,496(52,2); 2,491(23,4); 1,630(1,5); 1,611(2,6); 1,592(2,7); 1,574(1,6); 1,106(4,6); 1,089(10,0); 1,071(4,6); 1,051(4,4); 1,034(9,4); 1,016(4,1); 0,936(7,2); 0,918(16,0); 0,899(6,5); 0,000(8,3) Verbindung Nr.3699, Lösungsmittel [DMSO], 400 MHz  2,519 (1.7); 2,510 (24.7); 2,505 (53.9); 2,501 (75.3); 2,496 (52.2); 2,491 (23.4); 1,630 (1,5); 1,611 (2.6); 1,592 (2.7); 1.574 (1.6); 1,106 (4.6); 1,089 (10.0); 1,071 (4.6); 1,051 (4.4); 1,034 (9.4); 1.016 (4.1); 0.936 (7.2); 0.918 (16.0); 0.899 (6.5); 0.000 (8.3) Compound No. 3699, solvent [DMSO], 400 MHz
8,255(8,8); 3,339(3,9); 3,305(707,1); 3,289(4,7); 3,256(2,4); 2,674(5,4); 2,669(8,9); 8.255 (8.8); 3,339 (3.9); 3,305 (707.1); 3,289 (4.7); 3,256 (2.4); 2,674 (5.4); 2,669 (8.9);
2,665(5,1); 2,653(3,0); 2,632(2,6); 2,562(2,5); 2,523(20,0); 2,518(29,2); 2,509(406,4);2,665 (5.1); 2,653 (3.0); 2,632 (2.6); 2,562 (2.5); 2,523 (20.0); 2,518 (29.2); 2.509 (406.4);
2,505(888,3); 2,500(1241,1); 2,495(852,9); 2,491(377,0); 2,450(4,2); 2,445(3,9); 2.505 (888.3); 2.500 (1241.1); 2.495 (852.9); 2.491 (377.0); 2,450 (4.2); 2,445 (3.9);
2,331(4,9); 2,327(6,8); 2,322(4,6); 2,071(4,5); 1,622(2,1); 1,602(1,9); 1,122(6,8);  2.331 (4.9); 2,327 (6.8); 2,322 (4.6); 2,071 (4.5); 1,622 (2.1); 1.602 (1.9); 1,122 (6.8);
1 ,104(16,0); 1 ,086(6,7); 0,937(5,8); 0,918(12,2); 0,900(4,6); 0,008(3,6); 0,000(157,5); -1, 104 (16.0); 1, 086 (6,7); 0.937 (5.8); 0.918 (12.2); 0.900 (4.6); 0.008 (3.6); 0.000 (157.5); -
0,009(4,4) 0.009 (4.4)
Verbindung Nr.3807, Lösungsmittel [DMSO], 400 MHz Compound No. 3807, Solvent [DMSO], 400 MHz
7,594(2,8); 7,576(3,5); 7,559(2,5); 4,164(5,0); 4,060(3,7); 3,674(16,0); 3,603(10,8); 3,381(0,9); 3,363(2,6); 3,345(2,7); 3,328(0,9); 3,169(0,9); 3,160(0,8); 3,142(2,4);  7,594 (2.8); 7,576 (3.5); 7,559 (2.5); 4,164 (5.0); 4,060 (3.7); 3,674 (16.0); 3,603 (10.8); 3,381 (0.9); 3,363 (2.6); 3,345 (2.7); 3,328 (0.9); 3,169 (0.9); 3,160 (0.8); 3.142 (2.4);
3,124(2,4); 3,107(0,8); 2,944(8,8); 2,909(13,5); 2,620(1,0); 2,600(3,3); 2,581(3,7); 2,561(2,3); 2,524(1,1); 2,519(1,6); 2,510(23,5); 2,506(51,2); 2,501(71,6); 2,497(49,9); 2,492(22,3); 1,615(0,8); 1,597(1,7); 1,581(2,4); 1,566(2,3); 1,547(1,3); 1,101(3,0); 1,084(6,7); 1,066(3,0); 1,047(2,9); 1,029(6,4); 1,011(2,7); 0,951(3,1); 0,945(5,0); 0,933(7,8); 0,926(11,1); 0,916(5,7); 0,908(4,5); 0,898(1,9); 0,008(0,6); 0,000(20,7); - 0,009(0,6) 3,124 (2.4); 3,107 (0.8); 2,944 (8.8); 2,909 (13.5); 2,620 (1.0); 2,600 (3.3); 2,581 (3.7); 2,561 (2.3); 2,524 (1.1); 2,519 (1.6); 2,510 (23.5); 2,506 (51.2); 2,501 (71.6); 2,497 (49.9); 2,492 (22.3); 1,615 (0.8); 1,597 (1.7); 1,581 (2.4); 1,566 (2.3) 1,547 (1.3); 1,101 (3.0); 1,084 (6.7); 1,066 (3.0); 1,047 (2.9); 1,029 (6.4); 1,011 (2.7); 0.951 (3.1); 0.945 (5.0); 0.933 (7.8); 0.926 (11.1); 0.916 (5.7); 0.908 (4.5); 0.898 (1.9); 0.008 (0.6); 0,000 (20.7); - 0.009 (0.6)
Verbindung Nr.3170, Lösungsmittel [DMSO], 400 MHz Compound No. 3170, solvent [DMSO], 400 MHz
8,251 (4,5); 3,334(0,8); 3,310(18,8); 3,302(1 ,4); 3,299(1 ,3); 3,284(0,8); 2,704(0,5); 2,685(1,7); 2,666(1,9); 2,647(0,5); 2,520(0,5); 2,511(8,2); 2,506(18,0); 2,502(25,3); 2,497(17,6); 2,493(7,9); 1,610(0,5); 1,593(0,7); 1,577(0,6); 1,416(0,9); 1,398(1,7); 1,380(1,7); 1,362(0,7); 1,171(2,2); 1,152(5,5); 1,133(2,2); 0,901(16,0); 0,885(15,1); 0,000(6,4) 8.251 (4.5); 3,334 (0.8); 3,310 (18.8); 3.302 (1, 4); 3,299 (1, 3); 3,284 (0.8); 2,704 (0.5); 2,685 (1.7); 2,666 (1.9); 2,647 (0.5); 2,520 (0.5) 2,511 (8.2); 2,506 (18.0); 2,502 (25.3); 2,497 (17.6); 2,493 (7.9); 1,610 (0.5); 1,593 (0.7); 1,577 (0.6); 1.416 (0.9); 1,398 (1.7); 1,380 (1.7); 1,362 (0.7); 1,171 (2.2); 1.152 (5.5); 1,133 (2.2); 0.901 (16.0); 0.885 (15.1); 0.000 (6.4)
Verbindung Nr.3060, Lösungsmittel [DMSO], 400 MHz Compound No. 3060, solvent [DMSO], 400 MHz
8,162(5,1); 3,337(0,8); 3,313(5,2); 3,305(1,5); 3,302(1,5); 3,286(0,9); 2,701(0,6);  8.162 (5.1); 3,337 (0.8); 3,313 (5.2); 3,305 (1.5); 3,302 (1.5); 3,286 (0.9); 2,701 (0.6);
2,682(2,0); 2,663(2,1); 2,644(0,6); 2,513(3,8); 2,508(8,3); 2,504(11,5); 2,499(8,1); 2,495(3,8); 1,613(0,6); 1,596(0,8); 1,579(0,7); 1,418(1,0); 1,401(1,9); 1,382(1,9); 2,682 (2.0); 2,663 (2.1); 2,644 (0.6); 2,513 (3.8); 2,508 (8.3); 2,504 (11.5); 2,499 (8.1); 2,495 (3.8); 1,613 (0.6); 1,596 (0.8); 1,579 (0.7); 1,418 (1.0); 1,401 (1.9); 1,382 (1.9);
1,365(0,8); 1,180(2,5); 1,161(6,0); 1,142(2,5); 0,903(16,0); 0,886(15,2); 0,000(3,0) 1,365 (0.8); 1,180 (2.5); 1,161 (6.0); 1,142 (2.5); 0.903 (16.0); 0.886 (15.2); 0.000 (3.0)
Verbindung Nr.3303, Lösungsmittel [DMSO], 400 MHz Compound No. 3303, solvent [DMSO], 400 MHz
12,758(0,9); 9,650(1,9); 8,398(16,0); 3,477(0,7); 3,471(1,1); 3,466(1,3); 3,459(3,8); 3,447(5,2); 3,432(9,9); 3,423(6,7); 3,411(1,8); 3,404(1,0); 3,313(9,8); 3,265(51,4); 2,710(1 ,7); 2,691 (5,7); 2,672(6,0); 2,653(1 ,8); 2,512(13,5); 2,508(27,7); 2,503(37,4); 2,499(27,0); 2,494(12,8); 1,146(6,6); 1,127(15,2); 1,108(6,3); 0,000(6,6)  12.758 (0.9); 9,650 (1.9); 8.398 (16.0); 3,477 (0.7); 3,471 (1.1); 3,466 (1.3); 3,459 (3.8); 3,447 (5.2); 3,432 (9.9); 3,423 (6.7); 3,411 (1.8); 3,404 (1.0); 3,313 (9.8); 3,265 (51.4); 2,710 (1, 7); 2,691 (5.7); 2,672 (6.0); 2,653 (1, 8); 2,512 (13.5); 2,508 (27.7); 2,503 (37.4); 2,499 (27.0); 2,494 (12.8); 1,146 (6.6); 1,127 (15.2); 1,108 (6.3); 0.000 (6.6)
Verbindung Nr.3149, Lösungsmittel [DMSO], 400 MHz Compound No. 3149, solvent [DMSO], 400 MHz
12,856(1,0); 9,523(1,1); 8,253(8,3); 3,359(0,8); 3,339(1,3); 3,321(4,7); 3,308(101,1); 3,289(3,8); 3,271 (1 ,3); 3,259(0,9); 2,702(1 ,2); 2,684(4,0); 2,665(4,6); 2,646(1 ,3);  12,856 (1.0); 9,523 (1.1); 8,253 (8.3); 3,359 (0.8); 3,339 (1.3); 3,321 (4.7); 3.308 (101.1); 3,289 (3.8); 3,271 (1, 3); 3.259 (0.9); 2,702 (1, 2); 2,684 (4.0); 2,665 (4.6); 2,646 (1, 3);
2,550(1,0); 2,523(2,6); 2,510(48,7); 2,505(103,1); 2,501(142,0); 2,496(99,8); 2,550 (1.0); 2,523 (2.6); 2,510 (48.7); 2.505 (103.1); 2.501 (142.0); 2,496 (99.8);
2,492(45,9); 2,457(0,9); 2,327(0,8); 1,170(5,1); 1,151(12,1); 1,132(5,1); 1,122(7,5); 1,104(16,0); 1,086(7,2); 0,008(1,5); 0,000(46,5); -0,009(1,6) Verbindung Nr.3145, Lösungsmittel [DMSO], 400 MHz 2,492 (45.9); 2,457 (0.9); 2,327 (0.8); 1,170 (5.1); 1,151 (12.1); 1,132 (5.1); 1,122 (7.5); 1,104 (16.0); 1,086 (7.2); 0.008 (1.5); 0,000 (46.5); -0.009 (1.6) Compound No. 3145, solvent [DMSO], 400 MHz
7,519(3,4); 3,389(1,7); 3,372(5,2); 3,354(6,0); 3,336(12,5); 3,169(1,5); 3,151(4,7); 3,133(4,7); 3,115(1,5); 2,633(1,1); 2,614(3,0); 2,595(3,1); 2,576(1,2); 2,523(1,3);  7,519 (3.4); 3,389 (1.7); 3,372 (5.2); 3.354 (6.0); 3,336 (12.5); 3,169 (1.5); 3,151 (4.7); 3,133 (4.7); 3,115 (1.5); 2,633 (1.1); 2,614 (3.0); 2,595 (3.1); 2,576 (1.2); 2,523 (1.3);
2,519(1,8); 2,510(25,1); 2,506(54,7); 2,501(76,2); 2,496(53,1); 2,492(23,8); 1,172(0,5); 1,160(6,9); 1,141(16,0); 1,122(7,0); 1,107(6,1); 1,089(12,8); 1,071(5,9); 1,053(5,6); 1,035(11,9); 1,017(5,1); 0,008(1,0); 0,000(34,0); -0,009(1,0) 2,519 (1.8); 2,510 (25.1); 2,506 (54.7); 2,501 (76.2); 2,496 (53.1) 2,492 (23.8); 1,172 (0.5); 1,160 (6.9); 1,141 (16.0); 1,122 (7.0); 1,107 (6.1); 1,089 (12.8); 1,071 (5.9); 1,053 (5.6); 1.035 (11.9); 1,017 (5.1); 0.008 (1.0); 0,000 (34.0); -0.009 (1.0)
Verbindung Nr.3280, Lösungsmittel [DMSO], 400 MHz Compound No. 3280, Solvent [DMSO], 400 MHz
12,781 (0,6); 9,533(0,6); 8,388(5,0); 3,326(1 ,0); 3,308(50,8); 3,293(1 ,3); 3,276(0,8); 3,263(0,5); 2,706(0,5); 2,687(1,7); 2,668(1,9); 2,650(0,5); 2,523(1,3); 2,519(1,8); 12.781 (0.6); 9.533 (0.6); 8,388 (5.0); 3,326 (1, 0); 3,308 (50.8); 3,293 (1, 3); 3,276 (0.8); 3,263 (0.5); 2,706 (0.5); 2,687 (1.7); 2,668 (1.9); 2,650 (0.5); 2,523 (1.3); 2,519 (1.8);
2,510(25,7); 2,505(56,1); 2,501(78,1); 2,496(54,2); 2,492(24,3); 1,606(0,6); 1,589(0,7); 1,572(0,7); 1,409(0,9); 1,392(1,7); 1,373(1,8); 1,354(1,0); 1,143(2,1); 1,124(5,2); 2,510 (25.7); 2,505 (56.1); 2,501 (78.1); 2,496 (54.2); 2,492 (24.3); 1,606 (0.6); 1,589 (0.7); 1,572 (0.7); 1,409 (0.9); 1,392 (1.7); 1.373 (1.8); 1,354 (1.0); 1.143 (2.1); 1,124 (5.2);
1,105(2,1); 0,899(16,0); 0,882(15,4); 0,008(0,6); 0,000(21,4); -0,009(0,6) 1,105 (2.1); 0.899 (16.0); 0.882 (15.4); 0.008 (0.6); 0,000 (21.4); -0.009 (0.6)
Verbindung Nr.3039, Lösungsmittel [DMSO], 400 MHz Compound No. 3039, solvent [DMSO], 400 MHz
12,840(0,7); 9,539(0,8); 8,164(8,4); 3,342(1,0); 3,327(1,4); 3,324(3,5); 3,308(52,1); 3,291(3,4); 3,288(1,3); 3,273(1,1); 2,699(1,0); 2,680(3,5); 2,670(0,8); 2,662(3,6);  12.840 (0.7); 9,539 (0.8); 8,164 (8.4); 3,342 (1.0); 3,327 (1.4); 3,324 (3.5); 3,308 (52.1); 3,291 (3.4); 3,288 (1.3); 3,273 (1.1); 2,699 (1.0); 2,680 (3.5); 2,670 (0.8); 2,662 (3.6);
2,643(1,1); 2,524(1,2); 2,519(1,8); 2,510(26,9); 2,506(59,2); 2,501(83,2); 2,496(57,7); 2,492(25,9); 1,179(4,8); 1,160(11,7); 1,141(4,7); 1,124(7,1); 1,106(16,0); 1,088(6,9); 0,008(1,1); 0,000(35,7); -0,009(1,0) 2,643 (1.1); 2,524 (1.2); 2,519 (1.8); 2,510 (26.9); 2,506 (59.2); 2,501 (83.2); 2,496 (57.7); 2,492 (25.9); 1,179 (4.8); 1,160 (11.7); 1,141 (4.7); 1,124 (7.1); 1,106 (16.0); 1,088 (6.9); 0.008 (1.1); 0,000 (35.7); -0.009 (1.0)
Verbindung Nr.3040, Lösungsmittel [DMSO], 400 MHz Compound No. 3040, solvent [DMSO], 400 MHz
12,230(1,7); 9,813(1,0); 9,799(1,8); 9,785(0,9); 8,124(9,7); 3,311(75,2); 3,267(2,1); 3,250(4,2); 3,235(4,2); 3,218(2,0); 2,670(0,7); 2,666(0,5); 2,595(1 ,4); 2,576(4,4);  12.230 (1.7); 9.813 (1.0); 9,799 (1.8); 9.785 (0.9); 8.124 (9.7); 3,311 (75.2); 3,267 (2.1); 3,250 (4.2); 3,235 (4.2); 3,218 (2.0); 2,670 (0.7); 2,666 (0.5); 2,595 (1, 4); 2,576 (4.4);
2,557(4,6); 2,539(2,0); 2,523(2,8); 2,510(37,0); 2,506(73,5); 2,501(97,7); 2,497(69,9); 2,492(32,9); 2,416(2,9); 2,397(3,9); 2,378(3,0); 2,328(0,6); 1,541(0,5); 1,523(2,6); 1,505(5,8); 1,487(7,2); 1,468(5,0); 1,449(2,0); 1,154(5,1); 1,135(11,9); 1,116(5,2); 0,915(6,7); 0,905(8,4); 0,897(14,2); 0,887(16,0); 0,879(6,4); 0,868(6,8); 0,000(1,5)  2,557 (4.6); 2,539 (2.0); 2,523 (2.8); 2,510 (37.0); 2,506 (73.5); 2,501 (97.7); 2,497 (69.9); 2,492 (32.9); 2,416 (2.9); 2,397 (3.9); 2,378 (3.0); 2,328 (0.6); 1.541 (0.5); 1.523 (2.6); 1,505 (5.8); 1,487 (7.2); 1.468 (5.0); 1,449 (2.0); 1,154 (5.1); 1.135 (11.9); 1,116 (5.2); 0.915 (6.7); 0.905 (8.4); 0.897 (14.2); 0.887 (16.0); 0.879 (6.4); 0.868 (6.8); 0.000 (1.5)
Verbindung Nr.2929, Lösungsmittel [DMSO], 400 MHz Compound No. 2929, solvent [DMSO], 400 MHz
12,236(0,9); 9,750(0,6); 9,736(1,0); 9,722(0,6); 8,153(8,5); 3,331(1,2); 3,315(31,7); 3,299(3,2); 3,295(3,2); 3,281(3,1); 3,277(1,2); 3,263(1,0); 2,599(1,1); 2,580(3,5);  12.236 (0.9); 9,750 (0.6); 9,736 (1.0); 9,722 (0.6); 8,153 (8.5); 3,331 (1.2); 3,315 (31.7); 3,299 (3.2); 3,295 (3.2); 3,281 (3.1); 3,277 (1.2); 3,263 (1.0); 2,599 (1.1); 2,580 (3.5);
2,561(3,6); 2,542(1,3); 2,524(0,9); 2,520(1,3); 2,511(15,2); 2,506(32,6); 2,502(45,1); 2,497(31 ,4); 2,493(13,9); 2,469(1 ,3); 2,451 (4,2); 2,432(4,4); 2,413(1 ,4); 1 ,156(4,4); 1,137(11,1); 1,120(8,7); 1,109(6,0); 1,102(16,0); 1,090(13,8); 1,084(7,2); 1,071(5,4); 0,000(1,1) Verbindung Nr.3060, Lösungsmittel [DMSO], 400 MHz 2,561 (3.6); 2,542 (1.3); 2,524 (0.9); 2,520 (1.3); 2,511 (15.2); 2,506 (32.6); 2,502 (45.1); 2,497 (31, 4); 2,493 (13.9); 2,469 (1, 3); 2,451 (4.2); 2,432 (4.4); 2,413 (1, 4); 1, 156 (4,4); 1,137 (11.1); 1,120 (8.7); 1,109 (6.0); 1.102 (16.0); 1,090 (13.8); 1,084 (7.2); 1,071 (5.4); 0.000 (1.1) Compound No. 3060, solvent [DMSO], 400 MHz
12,214(0,8); 9,760(0,8); 8,121(4,8); 3,376(7,0); 3,324(0,9); 3,307(1,5); 3,290(1,5); 3,274(0,8); 2,594(0,6); 2,575(2,0); 2,557(2,0); 2,538(0,8); 2,524(0,9); 2,511(13,8); 2,506(28,1); 2,502(37,9); 2,497(26,9); 2,493(12,4); 2,415(1,3); 2,396(1,8); 2,376(1,4); 1 ,616(0,6); 1 ,599(0,9); 1 ,583(0,7); 1 ,505(0,8); 1 ,486(1 ,3); 1 ,467(1 ,3); 1 ,449(0,8);  12.214 (0.8); 9,760 (0.8); 8,121 (4.8); 3,376 (7.0); 3,324 (0.9); 3.307 (1.5); 3,290 (1.5); 3,274 (0.8); 2,594 (0.6); 2,575 (2.0); 2,557 (2.0); 2,538 (0.8); 2,524 (0.9); 2,511 (13.8); 2,506 (28.1); 2,502 (37.9); 2,497 (26.9); 2,493 (12.4); 2,415 (1.3); 2,396 (1,8); 2,376 (1.4); 1, 616 (0.6); 1, 599 (0.9); 1, 583 (0.7); 1, 505 (0.8); 1, 486 (1, 3); 1, 467 (1, 3); 1, 449 (0.8);
1,410(1,0); 1,392(2,1); 1,374(2,0); 1,357(0,8); 1,153(2,3); 1,134(5,4); 1,115(2,3); 1,410 (1.0); 1,392 (2.1); 1,374 (2.0); 1,357 (0.8); 1,153 (2.3); 1,134 (5.4); 1,115 (2.3);
0,915(3,3); 0,903(16,0); 0,897(7,5); 0,886(15,1); 0,879(3,1); 0,000(1,5) 0.915 (3.3); 0.903 (16.0); 0.897 (7.5); 0.886 (15.1); 0.879 (3.1); 0.000 (1.5)
Verbindung Nr.2930, Lösungsmittel [DMSO], 400 MHz Compound No. 2930, solvent [DMSO], 400 MHz
12,232(1 ,1 ); 9,815(0,7); 9,801 (1 ,2); 9,787(0,7); 8,153(9,6); 3,313(47,4); 3,270(1 ,9);12.232 (1, 1); 9.815 (0.7); 9,801 (1, 2); 9,787 (0.7); 8,153 (9.6); 3,313 (47.4); 3,270 (1, 9);
3,264(0,5); 3,252(3,5); 3,238(3,5); 3,220(1,9); 2,601(1,2); 2,582(3,9); 2,563(4,0); 3,264 (0.5); 3,252 (3.5); 3,238 (3.5); 3,220 (1.9); 2,601 (1.2); 2,582 (3.9); 2,563 (4.0);
2,544(1,2); 2,524(1,2); 2,519(1,6); 2,511(19,3); 2,506(41,3); 2,502(57,0); 2,497(39,5); 2,544 (1.2); 2,524 (1.2); 2,519 (1.6); 2,511 (19.3); 2,506 (41.3); 2,502 (57.0); 2,497 (39.5);
2,492(17,5); 2,471(1,5); 2,452(4,9); 2,433(4,8); 2,414(1,6); 1,523(2,0); 1,505(3,7);2,492 (17.5); 2,471 (1.5); 2,452 (4.9); 2,433 (4.8); 2,414 (1.6); 1.523 (2.0); 1,505 (3.7);
1,488(3,8); 1,470(2,2); 1,157(4,9); 1,138(12,1); 1,119(4,8); 1,109(6,3); 1,091(15,1); 1 ,072(6,0); 0,905(7,5); 0,887(16,0); 0,868(6,5); 0,000(1 ,4) 1,488 (3.8); 1,470 (2.2); 1,157 (4.9); 1,138 (12.1); 1,119 (4.8); 1,109 (6.3); 1,091 (15.1); 1, 072 (6,0); 0.905 (7.5); 0.887 (16.0); 0.868 (6.5); 0,000 (1, 4)
Verbindung Nr.3083, Lösungsmittel [DMSO], 400 MHz Compound No. 3083, solvent [DMSO], 400 MHz
12,224(1,5); 9,866(0,8); 9,855(1,6); 9,841(0,8); 8,130(12,4); 3,474(0,5); 3,468(0,8); 3,463(0,9); 3,456(3,0); 3,444(3,8); 3,440(3,6); 3,432(7,4); 3,429(7,7); 3,421(5,4);  12.224 (1.5); 9,866 (0.8); 9,855 (1.6); 9.841 (0.8); 8,130 (12.4); 3,474 (0.5); 3,468 (0.8); 3,463 (0.9); 3,456 (3.0); 3,444 (3.8); 3,440 (3.6); 3,432 (7.4); 3,429 (7.7); 3,421 (5.4);
3,420(5,2); 3,411 (1 ,0); 3,408(1 ,4); 3,401 (0,8); 3,359(17,0); 3,264(57,1 ); 2,597(1 ,3); 2,578(4,4); 2,560(4,6); 2,541(1,5); 2,524(1,3); 2,519(1,9); 2,511(23,7); 2,506(51,1); 2,501(71,0); 2,497(49,7); 2,492(22,1); 2,417(2,9); 2,398(3,7); 2,379(3,1); 1,506(1,7);3,420 (5.2); 3,411 (1, 0); 3.408 (1, 4); 3.401 (0.8); 3,359 (17.0); 3,264 (57.1); 2,597 (1, 3); 2,578 (4.4); 2,560 (4.6); 2,541 (1.5); 2,524 (1.3); 2,519 (1.9); 2,511 (23.7); 2,506 (51.1); 2,501 (71.0); 2,497 (49.7); 2,492 (22.1); 2,417 (2.9); 2,398 (3.7); 2,379 (3.1); 1,506 (1.7);
I, 487(2,8); 1,468(2,8); 1,449(1,7); 1,155(5,4); 1,136(13,5); 1,117(5,4); 0,914(7,2); 0,896(16,0); 0,878(6,3); 0,000(1,6) I, 487 (2.8); 1.468 (2.8); 1,449 (1.7); 1,155 (5.4); 1,136 (13.5); 1,117 (5.4); 0.914 (7.2); 0.896 (16.0); 0.878 (6.3); 0.000 (1.6)
Verbindung Nr.3021, Lösungsmittel [DMSO], 400 MHz Compound No. 3021, solvent [DMSO], 400 MHz
II, 706(0,7); 7,287(7,5); 7,284(10,9); 5,159(1,8); 5,147(1,6); 4,393(0,7); 4,358(0,7); 4,286(1,3); 4,275(1,2); 4,182(2,0); 4,164(6,3); 4,146(6,6); 4,128(2,4); 4,123(1,0);  II, 706 (0.7); 7.287 (7.5); 7,284 (10.9); 5,159 (1.8); 5,147 (1.6); 4,393 (0.7); 4,358 (0.7); 4,286 (1.3); 4,275 (1.2); 4,182 (2.0); 4,164 (6.3); 4,146 (6.6); 4,128 (2.4); 4,123 (1.0);
4,114(1,8); 4,103(0,8); 4,096(1,8); 4,085(1,8); 4,078(0,8); 4,067(1,7); 4,058(0,7); 4,114 (1.8); 4,103 (0.8); 4.096 (1.8); 4,085 (1.8); 4,078 (0.8); 4,067 (1.7); 4,058 (0.7);
4,050(0,6); 4,040(0,7); 3,528(3,9); 3,420(1 ,1 ); 3,387(1 ,3); 3,126(0,6); 3,117(0,6); 4,050 (0.6); 4,040 (0.7); 3,528 (3.9); 3,420 (1, 1); 3,387 (1, 3); 3,126 (0.6); 3,117 (0.6);
3,094(1,0); 3,087(1,0); 3,065(0,6); 3,054(0,5); 2,755(0,8); 2,524(2,1); 2,519(3,0); 3,094 (1.0); 3.087 (1.0); 3,065 (0.6); 3,054 (0.5); 2,755 (0.8); 2,524 (2.1); 2,519 (3.0);
2,511(26,0); 2,506(50,3); 2,502(67,6); 2,497(49,1); 2,492(25,2); 2,481(3,1); 2,476(2,9); 2,462(1,4); 2,401(1,3); 2,383(4,2); 2,364(4,7); 2,356(3,0); 2,345(2,1); 2,337(2,8); 2,511 (26.0); 2,506 (50.3); 2,502 (67.6); 2,497 (49.1); 2,492 (25.2); 2,481 (3.1); 2.476 (2.9); 2,462 (1.4); 2,401 (1.3); 2,383 (4.2); 2,364 (4.7); 2,356 (3.0); 2.345 (2.1); 2,337 (2.8);
2,329(1,0); 2,324(0,8); 2,319(1,1); 2,150(1,0); 2,116(1,0); 2,053(0,7); 2,020(0,9); 1,724(0,6); 1,716(0,6); 1,686(2,8); 1,656(3,2); 1,629(0,8); 1,619(0,5); 1,614(0,6); 2,329 (1.0); 2,324 (0.8); 2,319 (1.1); 2,150 (1.0); 2,116 (1.0); 2,053 (0.7); 2,020 (0.9); 1,724 (0.6); 1,716 (0.6); 1,686 (2.8); 1,656 (3.2); 1,629 (0.8); 1,619 (0.5); 1,614 (0.6);
1,530(1,7); 1,508(1,0); 1,476(0,6); 1,326(0,7); 1,307(0,8); 1,282(1,1); 1,243(8,3); 1,530 (1.7); 1,508 (1.0); 1,476 (0.6); 1,326 (0.7); 1,307 (0.8); 1,282 (1.1); 1,243 (8.3);
1,225(16,0); 1,208(7,7); 1,173(4,9); 1,155(11,2); 1,137(9,3); 1,133(12,1); 1,120(8,2); 1,114(5,8); 1,101(3,3); 1,081(5,5); 1,062(12,3); 1,052(4,6); 1,043(6,0); 1,034(8,2); 1,015(3,5); 0,000(1,3) 1,225 (16.0); 1,208 (7.7); 1,173 (4.9); 1,155 (11.2); 1,137 (9.3); 1,133 (12.1); 1,120 (8.2); 1,114 (5.8); 1,101 (3.3); 1,081 (5.5); 1,062 (12.3); 1.052 (4.6); 1.043 (6.0); 1,034 (8.2); 1,015 (3.5); 0.000 (1.3)
Verbindung Nr.2973, Lösungsmittel [DMSO], 400 MHz Compound No. 2973, solvent [DMSO], 400 MHz
12,226(1,3); 9,855(1,5); 9,841(0,8); 8,158(10,7); 3,457(7,3); 3,445(6,4); 3,430(8,2); 3,421(5,8); 3,412(1,4); 3,408(1,7); 3,402(1,0); 3,264(47,5); 2,670(0,7); 2,602(1,3); 2,583(4,5); 2,565(4,7); 2,552(0,6); 2,546(1 ,4); 2,523(1 ,9); 2,519(2,8); 2,510(35,8); 12.226 (1.3); 9,855 (1.5); 9.841 (0.8); 8,158 (10.7); 3,457 (7.3); 3,445 (6,4); 3,430 (8.2); 3,421 (5.8); 3,412 (1.4); 3,408 (1.7); 3,402 (1.0); 3,264 (47.5); 2,670 (0.7); 2,602 (1.3); 2,583 (4.5); 2,565 (4.7); 2,552 (0.6); 2,546 (1, 4); 2.523 (1, 9); 2,519 (2.8); 2,510 (35.8);
2,506(76,3); 2,501(105,4); 2,496(74,4); 2,492(33,8); 2,471(2,0); 2,452(5,6); 2,433(5,4); 2,415(1,8); 2,328(0,7); 1,157(5,3); 1,138(13,0); 1,119(5,3); 1,109(6,9); 1,090(16,0); 1,072(6,5); 0,008(1,5); 0,000(51,1); -0,009(1,6) Verbindung Nr.2925, Lösungsmittel [DMSO], 400 MHz 2,506 (76.3); 2.501 (105.4); 2,496 (74.4); 2,492 (33.8); 2,471 (2.0); 2,452 (5.6); 2,433 (5.4); 2,415 (1.8); 2,328 (0.7); 1,157 (5.3); 1,138 (13.0); 1,119 (5.3); 1,109 (6.9); 1,090 (16.0); 1,072 (6.5); 0.008 (1.5); 0,000 (51.1); -0.009 (1.6) Compound No. 2925, solvent [DMSO], 400 MHz
7,254(11,8); 3,388(0,9); 3,370(2,9); 3,352(3,0); 3,335(1,0); 3,166(0,9); 3,149(2,7); 7,254 (11.8); 3,388 (0.9); 3,370 (2.9); 3,352 (3.0); 3,335 (1.0); 3,166 (0.9); 3,149 (2.7);
3,131(2,8); 3,113(0,9); 2,524(0,9); 2,519(1,4); 2,510(22,0); 2,506(45,9); 2,501(64,3);3,131 (2.8); 3,113 (0.9); 2,524 (0.9); 2,519 (1.4); 2,510 (22.0); 2,506 (45.9); 2,501 (64.3);
2,496(45,8); 2,492(24,4); 2,472(4,7); 2,453(1,5); 2,381(1,4); 2,362(4,7); 2,343(4,8);2,496 (45.8); 2,492 (24.4); 2,472 (4.7); 2,453 (1.5); 2,381 (1.4); 2,362 (4.7); 2,343 (4.8);
2,332(0,6); 2,324(1,8); 1,142(5,2); 1,123(12,9); 1,109(4,0); 1,104(6,2); 1,091(7,0); 1,070(7,8); 1,052(16,0); 1,040(3,7); 1,033(7,2); 1,023(6,9); 1,005(3,1); 0,008(0,7);2,332 (0.6); 2,324 (1.8); 1,142 (5.2); 1,123 (12.9); 1,109 (4.0); 1,104 (6.2); 1,091 (7.0); 1,070 (7.8); 1.052 (16.0); 1,040 (3.7); 1,033 (7.2); 1,023 (6.9); 1.005 (3.1); 0.008 (0.7);
0,000(23,9); -0,009(0,7) 0,000 (23.9); -0.009 (0.7)
Verbindung Nr.3131, Lösungsmittel [DMSO], 400 MHz Compound No. 3131, solvent [DMSO], 400 MHz
11,701(0,7); 7,249(12,3); 5,157(1,5); 5,145(1,4); 4,388(0,7); 4,354(0,6); 4,286(1,2); 11.701 (0.7); 7,249 (12.3); 5,157 (1.5); 5,145 (1.4); 4,388 (0.7); 4,354 (0.6); 4,286 (1.2);
4,274(1,1); 4,180(1,7) 4,162(5,6); 4,145(5,9); 4,127(2,2); 4,120(0,7); 4,111(0,7); 4,274 (1.1); 4.170 (1.7) 4.162 (5.6); 4,145 (5.9); 4,127 (2.2); 4,120 (0.7); 4,111 (0.7);
4,102(1,9); 4,098(0,9) 4,084(2,0); 4,080(2,0); 4,066(0,9); 4,062(1,8); 4,053(0,6); 4,102 (1.9); 4,098 (0.9) 4.084 (2.0); 4,080 (2.0); 4,066 (0.9); 4,062 (1.8); 4,053 (0.6);
4,044(0,6); 4,035(0,6) 3,491(3,5); 3,418(1,1); 3,385(1,1); 3,120(0,5); 3,112(0,6); 4.044 (0.6); 4.035 (0.6) 3.491 (3.5); 3,418 (1.1); 3,385 (1.1); 3,120 (0.5); 3,112 (0.6);
3,089(0,9); 3,082(0,9) 3,058(0,5); 2,747(0,8); 2,524(2,1); 2,520(2,6); 2,511(21,1); 2,506(45,1); 2,502(618); 2,497(42,5); 2,493(20,2); 2,485(4,5); 2,475(2,1); 2,469(2,2);3,089 (0.9); 3.082 (0.9) 3.058 (0.5); 2,747 (0.8); 2,524 (2.1); 2,520 (2.6); 2,511 (21.1); 2,506 (45.1); 2.502 (618); 2,497 (42.5); 2,493 (20.2); 2,485 (4.5); 2,475 (2.1); 2,469 (2.2);
2,455(0,6) 2,451(0,5) 2,346(2,1); 2,328(3,6); 2,324(3,7); 2,307(3,6); 2,284(1,5); 2.455 (0.6) 2.451 (0.5) 2.346 (2.1); 2,328 (3.6); 2,324 (3.7); 2,307 (3.6); 2,284 (1.5);
2,150(0,9) 2,115(0,8) 2,057(0,6); 2,024(0,8); 1,719(0,6); 1,710(0,6); 1,683(2,5); 2.125 (0.9) 2.115 (0.8) 2.057 (0.6); 2,024 (0.8); 1,719 (0.6); 1,710 (0.6); 1,683 (2.5);
1,655(2,8) 1,628(0,7) 1,528(1,5); 1,509(0,7); 1,496(0,9); 1,476(1,7); 1,458(2,8); 1.655 (2.8) 1.628 (0.7) 1.528 (1.5); 1,509 (0.7); 1,496 (0.9); 1,476 (1.7); 1,458 (2.8);
1,438(2,8) 1,426(1,8) 1,420(1,9); 1,415(1,6); 1,408(1,4); 1,395(0,9); 1,325(0,6); 1.438 (2.8) 1.426 (1.8) 1.420 (1.9); 1.415 (1.6); 1,408 (1.4); 1,395 (0.9); 1.325 (0.6);
1,299(0,7) 1,275(0,9) 1,241(8,2); 1,223(16,0); 1,206(7,5); 1,170(5,0); 1,153(11,2); 1,149(5,5); 1,135(8,9); 1,130(10,7); 1,117(7,6); 1,111(5,0); 1,098(3,0); 0,905(5,4); 0,887(11,5); 0,869(7,2); 0,852(7,9); 0,834(3,3); 0,000(1,6) 1.299 (0.7) 1.275 (0.9) 1.241 (8.2); 1.223 (16.0); 1.206 (7.5); 1,170 (5.0); 1,153 (11.2); 1,149 (5.5); 1.135 (8.9); 1,130 (10.7); 1,117 (7.6); 1,111 (5.0); 1,098 (3.0); 0.905 (5.4); 0.887 (11.5); 0.869 (7.2); 0.852 (7.9); 0.834 (3.3); 0.000 (1.6)
Verbindung Nr.3035, Lösungsmittel [DMSO], 400 MHz Compound No. 3035, solvent [DMSO], 400 MHz
7,226(13,2); 3,386(1,0); 3,368(3,0); 3,351(3,1); 3,333(1,0); 3,167(1,0); 3,149(2,8); 3,132(2,8); 3,114(1,0); 2,525(0,6); 2,520(0,8); 2,511(10,0); 2,507(22,0); 2,502(29,2); 2,497(20,4); 2,493(9,7); 2,487(5,0); 2,468(4,6); 2,450(1,5); 2,331(2,9); 2,312(3,7); 2,293(3,0); 1,473(1,6); 1,454(2,8); 1,436(2,8); 1,417(1,7); 1,140(5,5); 1,121(13,7); 1,108(4,2); 1,102(6,6); 1,090(7,1); 1,073(3,4); 1,035(3,4); 1,017(6,7); 0,999(3,1); 7,226 (13.2); 3,386 (1.0); 3,368 (3.0); 3,351 (3.1); 3.333 (1.0); 3,167 (1.0); 3,149 (2.8); 3,132 (2.8); 3,114 (1.0); 2,525 (0.6); 2,520 (0.8); 2,511 (10.0); 2,507 (22.0); 2,502 (29.2); 2,497 (20.4); 2,493 (9.7); 2,487 (5.0); 2,468 (4.6); 2,450 (1.5); 2.331 (2.9); 2,312 (3.7); 2,293 (3.0); 1.473 (1.6); 1,454 (2.8); 1.436 (2.8); 1,417 (1.7); 1,140 (5.5); 1,121 (13.7); 1,108 (4.2); 1.102 (6.6); 1,090 (7.1); 1,073 (3.4); 1.035 (3.4); 1,017 (6.7); 0.999 (3.1);
0,892(7,2); 0,874(16,0); 0,856(6,3); 0,000(0,8) 0.892 (7.2); 0.874 (16.0); 0.856 (6.3); 0.000 (0.8)
Verbindung Nr.2951, Lösungsmittel [DMSO], 400 MHz Compound No. 2151, solvent [DMSO], 400 MHz
12,216(0,6); 9,761(0,7); 8,148(4,6); 3,326(1,4); 3,310(95,3); 3,293(1,5); 3,275(0,8); 2,670(0,6); 2,599(0,6); 2,580(2,0); 2,561(2,0); 2,542(0,8); 2,523(2,2); 2,518(3,2);  12.216 (0.6); 9.761 (0.7); 8,148 (4.6); 3,326 (1.4); 3,310 (95.3); 3,293 (1.5); 3,275 (0.8); 2,670 (0.6); 2,599 (0.6); 2,580 (2.0); 2,561 (2.0); 2,542 (0.8); 2,523 (2.2); 2,518 (3.2);
2,510(35,1); 2,505(73,6); 2,501(100,7); 2,496(70,4); 2,491(31,6); 2,469(0,8); 2,510 (35.1); 2,505 (73.6); 2.501 (100.7); 2,496 (70.4); 2,491 (31.6); 2,469 (0.8);
2,450(2,4); 2,431(2,3); 2,412(0,7); 2,327(0,6); 1,615(0,6); 1,599(0,8); 1,582(0,7);  2,450 (2.4); 2,431 (2.3); 2.412 (0.7); 2,327 (0.6); 1,615 (0.6); 1,599 (0.8); 1,582 (0.7);
1,410(0,9); 1,392(2,0); 1,374(1,9); 1,357(0,8); 1,155(2,3); 1,137(5,7); 1,118(2,4); 1,410 (0.9); 1,392 (2.0); 1,374 (1.9); 1,357 (0.8); 1,155 (2.3); 1,137 (5.7); 1,118 (2.4);
1,108(3,0); 1,090(6,8); 1,071(2,8); 0,903(16,0); 0,886(15,3); 0,000(1,3) Verbindung Nr.2927, Lösungsmittel [DMSO], 400 MHz 1,108 (3.0); 1,090 (6.8); 1,071 (2.8); 0.903 (16.0); 0.886 (15.3); 0.000 (1.3) Compound No. 2927, solvent [DMSO], 400 MHz
14,871(0,6); 11,755(0,6); 8,223(2,9); 7,339(5,6); 7,293(4,0); 4,161(5,2); 4,060(4,5); 14.871 (0.6); 11.755 (0.6); 8,223 (2.9); 7,339 (5.6); 7,293 (4.0); 4,161 (5.2); 4,060 (4.5);
3,673(16,0); 3,578(12,3); 3,311(50,8); 2,954(11,0); 2,915(15,1); 2,675(0,5); 2,667(1,7);3,673 (16.0); 3,578 (12.3); 3,311 (50.8); 2,954 (11.0); 2,915 (15.1); 2,675 (0.5); 2,667 (1.7);
2,648(1,5); 2,537(0,9); 2,533(0,8); 2,523(2,2); 2,518(5,0); 2,510(35,7); 2,506(76,4);2,648 (1.5); 2,537 (0.9); 2,533 (0.8); 2,523 (2.2); 2,518 (5.0); 2,510 (35.7); 2,506 (76.4);
2,501(107,6); 2,496(77,7); 2,492(34,4); 2,478(2,7); 2,458(0,8); 2,390(1,9); 2,371(2,3); 2,353(2,2); 2,334(1,8); 2,328(0,9); 2,323(0,6); 2,316(0,6); 1,189(1,8); 1,170(4,3); 2.501 (107.6); 2,496 (77.7); 2,492 (34.4); 2,478 (2.7); 2,458 (0.8); 2,390 (1.9); 2,371 (2.3); 2,353 (2.2); 2,334 (1.8); 2,328 (0.9); 2,323 (0.6); 2,316 (0.6); 1,189 (1.8); 1,170 (4.3);
1,151(4,0); 1,133(9,9); 1,114(12,0); 1,095(4,1); 1,086(3,1); 1,067(7,1); 1,048(4,9); 1,151 (4.0); 1,133 (9.9); 1,114 (12.0); 1,095 (4.1); 1,086 (3.1); 1.067 (7.1); 1,048 (4.9);
1,030(5,4); 1,011(2,2); 0,000(2,5) 1,030 (5.4); 1,011 (2.2); 0.000 (2.5)
Verbindung Nr.3039, Lösungsmittel [DMSO], 400 MHz Compound No. 3039, solvent [DMSO], 400 MHz
12,237(0,9); 9,749(0,7); 9,735(1 ,2); 9,721 (0,7); 8,127(9,7); 7,642(2,1 ); 7,016(5,4); 7,013(5,4); 3,332(1,9); 3,317(2,6); 3,314(4,4); 3,299(4,0); 3,295(3,9); 3,281(3,4); 12,237 (0.9); 9.749 (0.7); 9,735 (1, 2); 9,721 (0.7); 8,127 (9.7); 7,642 (2.1); 7,016 (5.4); 7,013 (5.4); 3,332 (1.9); 3,317 (2.6); 3,314 (4.4); 3,299 (4.0); 3,295 (3.9); 3,281 (3.4);
3,278(1,5); 3,263(1,1); 3,004(0,5); 3,000(1,4); 2,986(1,4); 2,982(1,5); 2,968(1,4); 3,278 (1.5); 3,263 (1.1); 3,004 (0.5); 3,000 (1.4); 2,986 (1.4); 2,982 (1.5); 2,968 (1.4);
2,964(0,5); 2,595(1,1); 2,576(3,7); 2,557(3,8); 2,538(1,2); 2,526(0,6); 2,521(0,8); 2,964 (0.5); 2,595 (1.1); 2,576 (3.7); 2,557 (3.8); 2,538 (1.2); 2,526 (0.6); 2,521 (0.8);
2,512(9,5); 2,508(20,3); 2,503(28,1); 2,498(19,5); 2,494(8,7); 2,416(2,3); 2,397(2,9); 2,377(2,5); 1 ,506(1 ,3); 1 ,487(2,2); 1 ,468(2,3); 1 ,449(1 ,4); 1 ,154(4,4); 1 ,135(10,8); 1 ,120(7,8); 1 ,1 16(4,8); 1 ,1 10(0,9); 1 ,102(16,0); 1 ,084(6,8); 0,987(2,9); 0,969(6,1 ); 0,951 (2,8); 0,915(5,7); 0,897(12,5); 0,878(5,0); 0,000(0,6) 2,512 (9.5); 2,508 (20.3); 2,503 (28.1); 2,498 (19.5); 2,494 (8.7); 2,416 (2.3); 2,397 (2.9); 2,377 (2.5); 1, 506 (1, 3); 1, 487 (2, 2); 1,468 (2,3); 1, 449 (1, 4); 1, 154 (4,4); 1, 135 (10.8); 1, 120 (7,8); 1, 16 (4.8); 1, 10 (0.9); 1, 102 (16.0); 1, 084 (6,8); 0.987 (2.9); 0.969 (6.1); 0.951 (2.8); 0.915 (5.7); 0.897 (12.5); 0.878 (5.0); 0.000 (0.6)
Gegenstand der vorliegenden Erfindung ist demnach die Verwendung mindestens einer Verbindung, ausgewählt aus der Gruppe, bestehend aus substituierten The present invention accordingly provides for the use of at least one compound selected from the group consisting of substituted
Pyridoncarboxamiden der allgemeinen Formel (I), sowie von beliebigen Mischungen dieser erfindungsgemäß substituierten Pyridoncarboxamide der allgemeinen Formel (I) mit ein oder mehreren agrochemischen Wirkstoffen entsprechend der unten stehenden Definition, zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischem, nicht durch Pestizide, bevorzugt nicht durch Herbizide ausgelösten Stress, insbesondere zur Stärkung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags. Pyridoncarboxamiden of the general formula (I), as well as any mixtures of these inventively substituted pyridone carboxamides of the general formula (I) with one or more agrochemical active substances as defined below, to increase the resistance of plants to abiotic, not by pesticides, preferably not by Herbicidal stress, in particular to enhance plant growth and / or increase plant yield.
Weiterer Gegenstand der vorliegenden Erfindung ist eine Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischem, nicht durch Pestizide, bevorzugt nicht durch Herbizide ausgelösten Stresswirksame Menge von mindestens einer Verbindung, ausgewählt aus der Gruppe, bestehend aus substituierten Pyridoncarboxamiden der allgemeinen Formel (I). Zu den dabei relativierbaren abiotischen Stressbedingungen können zum Beispiel Dürre, Kälte- und Hitzebedingungen, osmotischer Stress, Staunässe, erhöhter Bodensalzgehalt, erhöhtes Ausgesetztsein an Mineralien, Ozonbedingungen, Another object of the present invention is a spraying solution for the treatment of plants, comprising an effective to increase the resistance of plants to abiotic, not by pesticides, preferably not by herbicides induced stress effective amount of at least one compound selected from the group consisting of substituted pyridone carboxamides of general formula (I). For example, drought, cold and heat conditions, osmotic stress, waterlogging, increased soil salt content, increased exposure to minerals, ozone conditions,
Starklichtbedingungen, beschränkte Verfügbarkeit von Stickstoffnährstoffen, beschränkte Verfügbarkeit von Phosphornährstoffen zählen. High light conditions, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients.
In einer Ausführungsform kann beispielsweise vorgesehen sein, dass die For example, in one embodiment, it may be provided that the
erfindungsgemäß genannten substituierten Pyridoncarboxamide der allgemeinen Formel (I), durch eine Sprühapplikation auf entsprechende zu behandelnde Pflanzen oder Pflanzenteile aufgebracht werden. Die erfindungsgemäß vorgesehene Substituted Pyridoncarboxamide according to the invention of the general formula (I), be applied by a spray application to appropriate plants or plant parts to be treated. The inventively provided
Verwendung der erfindungsgemäßen Verbindungen der allgemeinen Formel (I) erfolgt vorzugsweise mit einer Dosierung zwischen 0,0005 und 3 kg/ha, besonders bevorzugt zwischen 0,001 und 2 kg/ha, insbesondere bevorzugt zwischen 0,005 und 1 kg/ha. Wenn im Rahmen der vorliegenden Erfindung Abscisinsäure gleichzeitig mit substituierten Pyridoncarboxamiden der allgemeinen Formel (I), beispielsweise in Rahmen einer gemeinsamen Zubereitung oder Formulierung verwendet wird, so erfolgt die Zumischung von Abscisinsäure dabei vorzugsweise in einer Dosierung zwischen 0,001 und 3 kg/ha, besonders bevorzugt zwischen 0,005 und 2 kg/ha, insbesondere bevorzugt zwischen 0,01 und 1 kg/ha. Use of the compounds of general formula (I) according to the invention is preferably carried out with a dosage between 0.0005 and 3 kg / ha, more preferably between 0.001 and 2 kg / ha, particularly preferably between 0.005 and 1 kg / ha. When in the context of the present invention abscisic acid simultaneously with Substituted Pyridoncarboxamiden of the general formula (I), for example in the context of a common preparation or formulation is used, the addition of abscisic acid is preferably carried out in a dosage between 0.001 and 3 kg / ha, more preferably between 0.005 and 2 kg / ha, in particular preferably between 0.01 and 1 kg / ha.
Unter der Bezeichnung Resistenz bzw. Widerstandsfähigkeit gegenüber abiotischem Stress werden im Rahmen der vorliegenden Erfindung verschiedenartige Vorteile für Pflanzen verstanden. Solche vorteilhaften Eigenschaften äußern sich beispielsweise in den nachfolgend genannten verbesserten Pflanzencharakteristika: verbessertesIn the context of the present invention, the term resistance or resistance to abiotic stress is understood to mean various advantages for plants. Such advantageous properties are manifested, for example, in the following improved plant characteristics: improved
Wurzelwachstum hinsichtlich Oberfläche und Tiefe, vermehrte Ausläuferbildung oder Bestückung, stärkere und produktivere Ausläufer und Bestockungstriebe, Root growth in terms of surface and depth, increased tailing or assembly, stronger and more productive foothills and tillers,
Verbesserung des Sproßwachstums, erhöhte Standfestigkeit, vergrößerte Improvement of shoot growth, increased stability, increased
Sprossbasisdurchmesser, vergrößerte Blattfläche, höhere Erträge an Nähr- und Inhaltsstoffen, wie z.B. Kohlenhydrate, Fette, Öle, Proteine, Vitamine, Mineralstoffe, ätherische Öle, Farbstoffe, Fasern, bessere Faserqualität, früheres Blühen, gesteigerte Blütenanzahl, reduzierter Gehalt an toxischen Produkten wie Mycotoxine, reduzierter Gehalt an Rückständen oder unvorteilhaften Bestandteilen jeglicher Art oder bessere Verdaulichkeit, verbesserte Lagerstabilität des Erntegutes, verbesserter Toleranz gegenüber unvorteilhaften Temperaturen, verbesserter Toleranz gegenüber Dürre und Trockenheit, wie auch Sauerstoffmangel durch Wasserüberschuß, verbesserte Shoot base diameter, increased leaf area, higher yields of nutrients and ingredients, e.g. Carbohydrates, fats, oils, proteins, vitamins, minerals, essential oils, dyes, fibers, better fiber quality, earlier flowering, increased number of flowers, reduced content of toxic products such as mycotoxins, reduced content of residues or unfavorable ingredients of any kind or better digestibility, improved Storage stability of the crop, improved tolerance to unfavorable temperatures, improved tolerance to drought and drought, as well as oxygen deficiency due to excess water, improved
Toleranz gegenüber erhöhten Salzgehalten in Böden und Wasser, gesteigerte Tolerance to increased salt levels in soils and water, increased
Toleranz gegenüber Ozonstress, verbesserte Verträglichkeit gegenüber Herbiziden und anderen Pflanzenbehandlungsmitteln, verbesserte Wasseraufnahme und Tolerance to ozone stress, improved tolerance to herbicides and other plant treatment agents, improved water absorption and
Photosyntheseleistung, vorteilhafte Pflanzeneigenschaften, wie beispielsweise Photosynthesis, beneficial plant properties, such as
Beschleunigung der Reifung, gleichmäßigere Abreife, größere Anziehungskraft für Nützlinge, verbesserte Bestäubung oder andere Vorteile, die einem Fachmann durchaus bekannt sind. Insbesondere zeigt die erfindungsgemäße Verwendung in der Sprühapplikation auf Pflanzen und Pflanzenteilen die beschriebenen Vorteile. Kombinationen der erfindungsmäß substituierten Pydridoncarboxamide der allgemeinen Formel (I) unter anderem mit Insektiziden, Lockstoffen, Akariziden, Fungiziden, Nematiziden, wachstumsregulierenden Stoffen, Safenern, die Pflanzenreife beeinflussenden Stoffen und Bakteriziden können bei der Bekämpfung von Pflanzenkrankheiten im Rahmen der vorliegenden Erfindung ebenfalls Anwendung finden. Die kombinierte Verwendung von entsprechenden substituierten Pydridoncarboxamiden der allgemeinen Formel (I) mit gentechnisch veränderten Sorten in Bezug auf erhöhte abiotische Stresstoleranz ist darüber hinaus ebenfalls möglich. Acceleration of ripening, more uniform ripening, greater attractiveness for beneficials, improved pollination or other benefits well known to those skilled in the art. In particular, the use according to the invention in the spray application to plants and parts of plants shows the advantages described. Combinations of erfindungsmäß substituted Pydridoncarboxamide the general formula (I), inter alia, with insecticides, attractants, acaricides, fungicides, nematicides, growth regulators, safeners, the plant maturity affecting substances and bactericides may also find application in the control of plant diseases in the present invention. The combined use of corresponding substituted Pydridoncarboxamiden the general formula (I) with genetically modified varieties in terms of increased abiotic stress tolerance is also possible.
Die weiter oben genannten verschiedenartigen Vorteile für Pflanzen lassen sich bekannterweise partiell zusammenfassen und mit allgemein gültigen Begriffen belegen. Solche Begriffe sind beispielsweise die nachfolgend aufgeführten The various advantages for plants mentioned above can, as is known, be partially summarized and substantiated by generally valid terms. Such terms are, for example, those listed below
Bezeichnungen: phytotonischer Effekt, Widerstandsfähigkeit gegenüber Terms: phytotonic effect, resistance to
Stressfaktoren, weniger Pflanzenstress, Pflanzengesundheit, gesunde Pflanzen, Pflanzenfitness, („Plant Fitness"),„Plant Wellness",„Plant Concept",„Vigor Effect", „Stress Shield", Schutzschild,„Crop Health",„Crop Health Properties",„Crop Health Products",„Crop Health Management",„Crop Health Therapy",„Plant Health", Plant Health Properties", Plant Health Products",„Plant Health Management",„Plant Health Therapy", Grünungseffekt („Greening Effect" oder„Re-greening Effect"),„Freshness" oder andere Begriffe, die einem Fachmann durchaus bekannt sind.  Stress Factors, Less Plant Stress, Plant Health, Healthy Plants, Plant Fitness, Plant Wellness, Plant Concept, Vigor Effect, Stress Shield, Shield, Crop Health, Crop Health Properties "Crop Health Products", "Crop Health Management", "Crop Health Therapy", "Plant Health", Plant Health Properties, "Plant Health Products", "Plant Health Management", "Plant Health Therapy", Greening Effect (" Greening effect "or" re-greening effect ")," Freshness "or other terms that are well known to a person skilled in the art.
Im Rahmen der vorliegenden Erfindung wird unter einem guten Effekt auf die In the present invention is under a good effect on the
Widerstandsfähigkeit gegenüber abiotischem Stress nicht beschränkend mindestens ein um im Allgemeinen 3 %, insbesondere größer als 5 %, besonders bevorzugt größer als 10 % verbessertes Auflaufen, Resistance to abiotic stress not limited to at least one accumulation, generally improved by 3%, in particular greater than 5%, particularly preferably greater than 10%,
mindestens einen im Allgemeinen 3 %, insbesondere größer als 5 %, besonders bevorzugt größer als 10 % gesteigerten Ertrag,  at least one generally 3%, in particular greater than 5%, particularly preferably greater than 10% increased yield,
mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 %, besonders bevorzugt größer als 10 % verbesserte Wurzelentwicklung, mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 %, besonders bevorzugt größer als 10 % ansteigende Sproßgröße,  at least one root development improved by generally 3%, in particular greater than 5%, particularly preferably greater than 10%, at least one shoot size increasing by generally 3%, in particular greater than 5%, particularly preferably greater than 10%,
· mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 %, · At least one in general 3%, in particular greater than 5%,
besonders bevorzugt größer als 10 % vergrößerte Blattfläche,  more preferably greater than 10% increased leaf area,
mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 %, besonders bevorzugt größer als 10 % verbesserte Photosyntheseleistung und/oder mindestens eine um im Allgemeinen 3 %, insbesondere größer als 5 %, besonders bevorzugt größer als 10 % verbesserte Blütenausbildung verstanden, wobei die Effekte einzeln oder aber in beliebiger Kombination von zwei oder mehreren Effekten auftreten können. at least one in general 3%, in particular greater than 5%, particularly preferably greater than 10% improved photosynthesis and / or at least one flower formation generally improved by 3%, in particular greater than 5%, particularly preferably greater than 10%, the effects being able to occur individually or else in any desired combination of two or more effects.
Weiterer Gegenstand der vorliegenden Erfindung ist eine Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge von mindestens einer A further subject of the present invention is a spray solution for the treatment of plants, comprising an amount of at least one effective for increasing the resistance of plants to abiotic stress factors
Verbindung der allgemeinen Formel (I). Die Sprühlösung kann andere übliche Compound of the general formula (I). The spray solution may be other common
Bestandteile aufweisen, wie Lösungsmittel, Formulierhilfsstoffe, insbesondere Wasser, enthalten. Weitere Bestandteile können unter anderem agrochemische Wirkstoffe sein, welche unten noch weiter beschrieben werden. Weiterer Gegenstand der vorliegenden Erfindung ist die Verwendung von  Have constituents such as solvents, formulation auxiliaries, especially water. Other ingredients may include agrochemical agents, which are further described below. Another object of the present invention is the use of
entsprechenden Sprühlösungen zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren. Die nachfolgenden Ausführungen gelten sowohl für die erfindungsgemäße Verwendung der Verbindungen der allgemeinen Formel (I) an sich als auch für die entsprechenden Sprühlösungen. corresponding spray solutions to increase the resistance of plants to abiotic stress factors. The following statements apply both to the inventive use of the compounds of general formula (I) per se and for the corresponding spray solutions.
Erfindunsgemäß wurde darüber hinaus gefunden, dass die Anwendung der According to the invention, it has also been found that the application of the
Verbindungen der allgemeinen Formel (I) in Kombination mit mindestens einem Compounds of general formula (I) in combination with at least one
Düngemittel wie weiter unten stehend definiert auf Pflanzen oder in deren Umgebung möglich ist. Fertilizers as defined below are possible on plants or in their environment.
Düngemittel, die erfindungsgemäß zusammen mit den oben näher erläuterten Fertilizers according to the invention together with the above explained in more detail
Verbindungen der allgemeinen Formel (I) verwendet werden können, sind im Compounds of the general formula (I) can be used are in
Allgemeinen organische und anorganische Stickstoff-haltige Verbindungen wie beispielsweise Harnstoffe, Harnstoff-Formaldehyd-Kondensationsprodukte, General organic and inorganic nitrogen-containing compounds such as, for example, ureas, urea-formaldehyde condensation products,
Aminosäuren, Ammoniumsalze und -nitrate, Kaliumsalze (bevorzugt Chloride, Sulfate, Nitrate), Phosphorsäuresalze und/oder Salze von Phosphoriger Säure (bevorzugt Kaliumsalze und Ammoniumsalze). Insbesondere zu nennen sind in diesem Amino acids, ammonium salts and nitrates, potassium salts (preferably chlorides, sulfates, nitrates), phosphoric acid salts and / or salts of phosphorous acid (preferably potassium salts and ammonium salts). To name in particular are in this
Zusammenhang die NPK-Dünger, d.h. Düngemittel, die Stickstoff, Phosphor und Kalium enthalten, Kalkammonsalpeter, d.h. Düngemittel, die noch Calcium enthalten, Ammonsulfatsalpeter (Allgemeine Formel (NH4)2SO4 NH4NO3), Ammonphosphat und Ammonsulfat. Diese Düngemittel sind dem Fachmann allgemein bekannt, siehe auch beispielsweise Ullmann's Encyclopedia of Industrial Chennistry, 5. Edition, Vol. A 10, Seiten 323 bis 431 , Verlagsgesellschaft, Weinheim, 1987. Related NPK fertilizers, ie fertilizers containing nitrogen, phosphorus and potassium, calcium ammonium nitrate, ie fertilizers which still contain calcium, Ammonium sulfate nitrate (general formula (NH 4 ) 2SO 4 NH 4 NO 3), ammonium phosphate and ammonium sulfate. These fertilizers are generally known to the person skilled in the art, see also, for example, Ullmann's Encyclopedia of Industrial Chennistry, 5th Edition, Vol. A 10, pages 323 to 431, Verlagsgesellschaft, Weinheim, 1987.
Die Düngemittel können auch Salze aus Mikronährstoffen (bevorzugt Calcium, The fertilizers may also contain salts of micronutrients (preferably calcium,
Schwefel, Bor, Mangan, Magnesium, Eisen, Bor, Kupfer, Zink, Molybdän und Kobalt) und Phytohormonen (z. B. Vitamin B1 und Indol-(lll)essigsäure) oder Gemische davon enthalten. Erfindungsgemäß eingesetzte Düngemittel können auch weitere Salze wie Monoammoniumphosphat (MAP), Diammoniumphosphat (DAP), Kaliumsulfat, Sulfur, boron, manganese, magnesium, iron, boron, copper, zinc, molybdenum and cobalt) and phytohormones (eg, vitamin B1 and indole (III) acetic acid) or mixtures thereof. Fertilizers used according to the invention may also contain other salts such as monoammonium phosphate (MAP), diammonium phosphate (DAP), potassium sulfate,
Kaliumchlorid, Magnesiumsulfat enthalten. Geeignete Mengen für die sekundären Nährstoffe oder Spurenelemente sind Mengen von 0,5 bis 5 Gew.-%, bezogen auf das gesamte Düngemittel. Weitere mögliche Inhaltsstoffe sind Pflanzenschutzmittel, Insektizide oder Fungizide, Wachstumsregulatoren oder Gemische davon. Hierzu folgen weiter unten weitergehende Ausführungen. Containing potassium chloride, magnesium sulfate. Suitable amounts for the secondary nutrients or trace elements are amounts of 0.5 to 5 wt .-%, based on the total fertilizer. Further possible ingredients are crop protection agents, insecticides or fungicides, growth regulators or mixtures thereof. Further explanations follow below.
Die Düngemittel können beispielsweise in Form von Pulvern, Granulaten, Prills oder Kompaktaten eingesetzt werden. Die Düngemittel können jedoch auch in flüssiger Form, gelöst in einem wässrigen Medium, eingesetzt werden. In diesem Fall kann auch verdünnter wässriger Ammoniak als Stickstoffdüngemittel eingesetzt werden. Weitere mögliche Inhaltsstoffe für Düngemittel sind beispielsweise in Ullmann's The fertilizers can be used, for example, in the form of powders, granules, prills or compactates. However, the fertilizers can also be used in liquid form dissolved in an aqueous medium. In this case, dilute aqueous ammonia can be used as nitrogen fertilizer. Further possible ingredients for fertilizers are, for example, in Ullmann's
Encyclopedia of Industrial Chemistry, 5. Auflage, 1987, Band A 10, Seiten 363 bis 401 , DE-A 41 28 828, DE-A 19 05 834 und DE-A 196 31 764 beschrieben. Die allgemeine Zusammensetzung der Düngemittel, bei welchen es sich im Rahmen der vorliegenden Erfindung um Einzelnährstoff- und/oder Mehrnährstoffdünger handeln kann, Encyclopedia of Industrial Chemistry, 5th edition, 1987, Volume A 10, pages 363 to 401, DE-A 41 28 828, DE-A 19 05 834 and DE-A 196 31 764 described. The general composition of the fertilizers, which in the context of the present invention may be single-nutrient and / or complex nutrient fertilizers,
beispielsweise aus Stickstoff, Kalium oder Phosphor, kann innerhalb eines breiten Bereichs variieren. Im Allgemeinen ist ein Gehalt von 1 bis 30 Gew.-% Stickstoff (bevorzugt 5 bis 20 Gew.-%), von 1 bis 20 Gew.-% Kalium (bevorzugt 3 bis 15 Gew.- %) und ein Gehalt von 1 bis 20 Gew.-% Phosphor (bevorzugt 3 bis 10 Gew.-%) vorteilhaft. Der Gehalt von Mikroelementen ist üblicherweise im ppm-Bereich, bevorzugt im Bereich von von 1 bis 1000 ppm. For example, nitrogen, potassium or phosphorus may vary within a wide range. In general, a content of 1 to 30 wt .-% of nitrogen (preferably 5 to 20 wt .-%), from 1 to 20 wt .-% potassium (preferably 3 to 15% by weight) and a content of 1 to 20% by weight of phosphorus (preferably 3 to 10% by weight) is advantageous. The content of microelements is usually in the ppm range, preferably in the range of from 1 to 1000 ppm.
Im Rahmen der vorliegenden Erfindung kann das Düngemittel sowie die Verbindungen der allgemeinen Formel (I) zeitgleich, d.h. synchron, verabreicht werden. Es ist jedoch auch möglich, zunächst das Düngemittel und dann eine Verbindung der Formel (I) oder zunächst eine Verbindung der Formel (I) und dann das Düngemittel anzuwenden. Bei nicht zeitgleicher Anwendung einer Verbindung der allgemeinen Formel (I) und des Düngemittels erfolgt im Rahmen der vorliegenden Erfindung jedoch die Anwendung in funktionellem Zusammenhang, insbesondere innerhalb eines Zeitraums von im In the context of the present invention, the fertilizer and the compounds of the general formula (I) can be administered simultaneously, ie synchronously. However, it is also possible first to use the fertilizer and then a compound of the formula (I) or first to apply a compound of formula (I) and then the fertilizer. In the case of non-simultaneous application of a compound of general formula (I) and of the fertilizer, however, in the context of the present invention the application takes place in a functional connection, in particular within a period of
Allgemeinen 24 Stunden, bevorzugt 18 Stunden, besonders bevorzugt 12 Stunden, speziell 6 Stunden, noch spezieller 4 Stunden, noch weiter spezieller innerhalb 2 Stunden. In ganz besonderen Ausführungsformen der vorliegenden Erfindung erfolgt die Anwendung der erfindungsgemäßen Verbindung der allgemeinen Formel (I) und des Düngemittels in einem zeitlichen Rahmen von weniger als 1 Stunden, Generally 24 hours, preferably 18 hours, more preferably 12 hours, especially 6 hours, even more specifically 4 hours, even more specifically within 2 hours. In very particular embodiments of the present invention, the application of the compound of the general formula (I) and of the fertilizer according to the invention takes place within a time frame of less than 1 hour,
vorzugsweise weniger als 30 Minuten, besonders bevorzugt weniger als 15 Minuten. preferably less than 30 minutes, more preferably less than 15 minutes.
Die erfindungsgemäß zu verwendenden Wirkstoffe können, gegebenenfalls in The active compounds to be used according to the invention can, optionally in
Kombination mit Düngemitteln, bevorzugt an folgenden Pflanzen angewendet werden, wobei die folgende Aufzählung nicht beschränkend ist. Combined with fertilizers, preferably applied to the following plants, the following list is not limiting.
Bevorzugt sind Pflanzen aus der Gruppe der Nutzpflanzen, Zierpflanzen, Rasenarten, allgemein genutzte Bäume, die in öffentlichen und privaten Bereichen als Zierpflanzen Verwendungen finden, und Forstbestand. Der Forstbestand umfasst Bäume für die Herstellung von Holz, Zellstoff, Papier und Produkten die aus Teilen der Bäume hergestellt werden. Der Begriff Nutzpflanzen, wie hier verwendet, bezeichnet Preference is given to plants from the group of crops, ornamental plants, lawn species, generally used trees, which are used as ornamental plants in public and private areas, and forest stands. The forest stock includes trees for the production of wood, pulp, paper and products made from parts of the trees. The term crops as used herein refers to
Kulturpflanzen, die als Pflanzen für die Gewinnung von Nahrungsmitteln, Futtermitteln, Treibstoffe oder für technische Zwecke eingesetzt werden.  Crop plants used as plants for the production of food, feed, fuel or for technical purposes.
Zu den Nutzpflanzen zählen z. B. folgende Pflanzenarten: Triticale, Durum Among the useful plants include z. For example, the following plant species: Triticale, Durum
(Hartweizen), Turf, Reben, Getreide, beispielsweise Weizen, Gerste, Roggen, Hafer, Höpen, Reis, Mais und Hirse; Rüben, beispielsweise Zuckerrüben und Futterrüben; Früchte, beispielsweise Kernobst, Steinobst und Beerenobst, beispielsweise Äpfel, Birnen, Pflaumen, Pfirsiche, Mandeln, Kirschen und Beeren, z. B. Erdbeeren, (Durum wheat), turf, vines, cereals, for example wheat, barley, rye, oats, hops, rice, corn and millet; Beets, for example sugar beets and fodder beets; Fruits, such as pome fruit, stone fruit and soft fruit, such as apples, pears, plums, peaches, almonds, cherries and berries, eg. Strawberries,
Himbeeren, Brombeeren; Hülsenfrüchte, beispielsweise Bohnen, Linsen, Erbsen und Sojabohnen; Ölkulturen, beispielsweise Raps, Senf, Mohn, Oliven, Sonnenblumen, Kokos, Castorölpflanzen, Kakaobohnen und Erdnüsse; Gurkengewächse, Raspberries, blackberries; Legumes, such as beans, lentils, peas and soybeans; Oil crops such as rapeseed, mustard, poppy, olive, sunflower, coconut, castor oil, cocoa beans and peanuts; Cucumber plants,
beispielsweise Kürbis, Gurken und Melonen; Fasergewächse, beispielsweise for example, pumpkin, cucumbers and melons; Fiber plants, for example
Baumwolle, Flachs, Hanf und Jute; Citrusfrüchte, beispielsweise Orangen, Zitronen, Pampelmusen und Mandarinen; Gemüsesorten, beispielsweise Spinat, (Kopf)-Salat, Spargel, Kohlarten, Möhren, Zwiebeln, Tomaten, Kartoffeln und Paprika; Lorbeergewächse, beispielsweise Avocado, Cinnamonum, Kampfer, oder ebenso Pflanzen wie Tabak, Nüsse, Kaffee, Aubergine, Zuckerrohr, Tee, Pfeffer, Weinreben, Hopfen, Bananen, Naturkautschukgewächse sowie Zierpflanzen, beispielsweise Blumen, Sträucher, Laubbäume und Nadelbäume wie Koniferen. Diese Aufzählung stellt keine Limitierung dar. Cotton, flax, hemp and jute; Citrus fruits, such as oranges, lemons, grapefruit and mandarins; Vegetables, such as spinach, (head) salad, Asparagus, cabbages, carrots, onions, tomatoes, potatoes and peppers; Laurel family, such as avocado, cinnamonum, camphor, or as plants such as tobacco, nuts, coffee, eggplant, sugar cane, tea, pepper, vines, hops, bananas, natural rubber plants and ornamental plants, such as flowers, shrubs, deciduous trees and conifers such as conifers. This list is not a limitation.
Als besonders geeignete Zielkulturen für die Anwendung des erfindungsgemäßen Verfahrens sind folgende Pflanzen anzusehen: Hafer, Roggen, Triticale, Durum, Bamwolle, Aubergine, Turf, Kernobst, Steinobst, Beerenobst, Mais, Weizen, Gerste, Gurke, Tabak, Reben, Reis, Getreide, Birne, Pfeffer, Bohnen, Sojabohnen, Raps, Tomate, Paprika, Melonen, Kohl, Kartoffel und Apfel. Oats, rye, triticale, durum, bamboo wool, aubergine, turf, pome fruit, stone fruit, berry fruit, maize, wheat, barley, cucumber, tobacco, vines, rice, cereals are to be regarded as particularly suitable target cultures for the application of the method according to the invention , Pear, pepper, beans, soybeans, rape, tomato, paprika, melons, cabbage, potato and apple.
Als Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, seien beispielhaft genannt: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp., Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.. Examples of trees which can be improved according to the method of the invention are: Abies sp., Eucalyptus sp., Picea sp., Pinus sp., Aesculus sp., Platanus sp., Tilia sp., Acer sp., Tsuga sp , Fraxinus sp., Sorbus sp., Betula sp., Crataegus sp., Ulmus sp., Quercus sp., Fagus sp., Salix sp., Populus sp.
Als bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Aus der Baumart Aesculus: A. hippocastanum, A. pariflora, A. carnea; aus der Baumart Platanus: P. aceriflora, P. occidentalis, P. racemosa; aus der Baumart Picea: P. abies; aus der Baumart Pinus:As preferred trees, which can be improved according to the method of the invention, may be mentioned: From the tree species Aesculus: A. hippocastanum, A. pariflora, A. carnea; from the tree species Platanus: P. aceriflora, P. occidentalis, P. racemosa; from the tree species Picea: P. abies; from the tree species Pinus:
P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P. P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. elliottii, P. montecola, P.
albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P. jeffregi, P. baksiana, P. strobes; aus der Baumart Eucalyptus: E. grandis, E. globulus, E. camadentis, E. albicaulis, P. resinosa, P. palustris, P. taeda, P. flexilis, P. jeffregi, P. baksiana, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus, E. camadentis, E.
nitens, E. obliqua, E. regnans, E. pilularus. nitens, E. obliqua, E. regnans, E. pilularus.
Als besonders bevorzugte Bäume, die entsprechend dem erfindungsgemäßen Verfahren verbessert werden können, können genannt werden: Aus der Baumart Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; aus der Baumart Eucalyptus: E. grandis, E. globulus und E. camadentis. Als besonders bevorzugte Bäume, die entsprechend dem erfindungsgemäßen As particularly preferred trees, which can be improved according to the method of the invention, may be mentioned: From the species Pinus: P. radiate, P. ponderosa, P. contorta, P. sylvestre, P. strobes; from the tree species Eucalyptus: E. grandis, E. globulus and E. camadentis. As particularly preferred trees, according to the invention
Verfahren verbessert werden können, können genannt werden: Rosskastanie, Procedures can be improved: horse chestnut,
Platanengewächs, Linde und Ahornbaum. Die vorliegende Erfindung kann auch an beliebigen Rasenarten („turfgrasses") durchgeführt werden, einschließlich„cool season turfgrasses" und„warm season turfgrasses". Beispiele für Rasenarten für die kalte Jahreszeit sind Blaugräser („blue grasses"; Poa spp.), wie„Kentucky bluegrass" (Poa pratensis L),„rough bluegrass" (Poa trivialis L),„Canada bluegrass" (Poa compressa L),„annual bluegrass" (Poa annua L),„upland bluegrass" (Poa glaucantha Gaudin),„wood bluegrass" (Poa nemoralis L.) und„bulbous bluegrass" (Poa bulbosa L); Straussgräser („Bentgrass", Agrostis spp.), wie„creeping bentgrass" (Agrostis palustris Huds.),„colonial bentgrass" (Agrostis tenuis Sibth.),„velvet bentgrass" (Agrostis canina L),„South German Mixed Bentgrass" (Agrostis spp. einschließlich Agrostis tenius Sibth., Agrostis canina L, und Agrostis palustris Huds.), und„redtop" (Agrostis alba L); Sycamore plant, linden and maple tree. The present invention may also be practiced on any turfgrasses, including "cool season turfgrasses" and "warm season turfgrasses." Examples of cold season turf species are blue grasses (Poa spp.), Such as "Kentucky bluegrass" (Poa pratensis L), "rough bluegrass" (Poa trivialis L), "Canada bluegrass" (Poa compressa L), "annual bluegrass" (Poa annua L), "upland bluegrass" (Poa glaucantha Gaudin), "Wood bluegrass" (Poa nemoralis L.) and "bulbous bluegrass" (Poa bulbosa L); ostrich grasses ("Bentgrass", Agrostis spp.), Such as "creeping bentgrass" (Agrostis palustris Huds.), "Colonial bentgrass" (Agrostis Tenuis Sibth.), "velvet bentgrass" (Agrostis canina L), "South German Mixed Bentgrass" (Agrostis spp., including Agrostis tenius Sibth., Agrostis canina L, and Agrostis palustris Huds.), and "redtop" (Agrostis alba L );
Schwingel („Fescues", Festucu spp.), wie„red fescue" (Festuca rubra L. spp. rubra), „creeping fescue" (Festuca rubra L),„chewings fescue" (Festuca rubra commutata Gaud.),„sheep fescue" (Festuca ovina L),„hard fescue" (Festuca longifolia Thuill.), „hair fescue" (Festucu capillata Lam.),„tall fescue" (Festuca arundinacea Schreb.) und „meadow fescue" (Festuca elanor L.); Fescue ("Fescues", Festucu spp.), Such as "red fescue" (Festuca rubra L. spp. Rubra), "creeping fescue" (Festuca rubra L), "chewings fescue" (Festuca rubra commutata Gaud.), "Sheep fescue "(Festuca ovina L)," hard fescue "(Festuca longifolia Thuill.)," hair fescue "(Festucu capillata Lam.)," tall fescue "(Festuca arundinacea Schreb.) and" meadow fescue "(Festuca elanor L. );
Lolch („ryegrasses", Lolium spp.), wie„annual ryegrass" (Lolium multiflorum Lam.), „perennial ryegrass" (Lolium perenne L.) und„italian ryegrass" (Lolium multiflorum Lam.); und Weizengräser ("wheatgrasses", Agropyron spp..), wie "fairway wheatgrass" (Agropyron cristatum (L.) Gaertn.),„crested wheatgrass" (Agropyron desertorum (Fisch.) Schult.) und "western wheatgrass" (Agropyron smithii Rydb.). Lolium ("ryegrasses", Lolium spp.), Such as "annual ryegrass" (Lolium multiflorum Lam.), "Perennial ryegrass" (Lolium perenne L.) and "Italian ryegrass" (Lolium multiflorum Lam.); and wheat grasses ("wheatgrasses", Agropyron spp.), such as "fairway wheatgrass" (Agropyron cristatum (L.) Gaertn.), "crested wheatgrass" (Agropyron desertorum (fish.) Schult.) and "western wheatgrass" (Agropyron smithii Rydb.).
Beispiele für weitere "cool season turfgrasses" sind "beachgrass" (Ammophila breviligulata Fern.), "smooth bromegrass" (Bromus inermis Leyss.), Schilf ("cattails") wie "Timothy" (Phleum pratense L.), "sand cattail" (Phleum subulatum L.), "orchardgrass" (Dactylis glomerata L), "weeping alkaligrass" (Puccinellia distans (L.) Pari.) und "crested dog's-tail" (Cynosurus cristatus L.). Examples of other "cool season turfgrasses" are "beachgrass" (Ammophila breviligulata Fern.), "Smooth bromegrass" (Bromus inermis leyss.), Reeds ("cattails") such as "Timothy" (Phleum pratense L.), "sand cattail "(Phleum subulatum L.) "orchardgrass" (Dactylis glomerata L), "weeping alkaligrass" (Puccinellia distans (L.) Pari.) and "crested dog's-tail" (Cynosurus cristatus L.).
Beispiele für "warm season turfgrasses" sind„Bermudagrass" (Cynodon spp. L. C. Rieh), "zoysiagrass" (Zoysia spp. Willd.),„St. Augustine grass" (Stenotaphrum secundatum Walt Kuntze),„centipedegrass" (Eremochloa ophiuroides Munro Hack.), „carpetgrass" (Axonopus affinis Chase),„Bahia grass" (Paspalum notatum Flügge), „Kikuyugrass" (Pennisetum clandestinum Höchst, ex Chiov.),„buffalo grass" (Buchloe daetyloids (Nutt.) Engelm.), "Blue gramma" (Bouteloua gracilis (H.B.K.) Lag. ex Examples of "warm season turfgrasses" are "Bermudagrass" (Cynodon spp., LC Rieh), "zoysiagrass" (Zoysia spp. Willd.), "St. Augustine grass" (Stenotaphrum secundatum Walt Kuntze), "centipedegrass" (Eremochloa ophiuroides Munro Hack.), "Carpetgrass" (Axonopus affinis chase), "Bahia grass" (Paspalum notatum flügge), "Kikuyugrass" (Pennisetum clandestinum Höchst, ex Chiov.), "Buffalo grass" (Buchloe daetyloids (Nutt.) Engelm.) , "Blue gramma" (Bouteloua gracilis (HBK) lag. Ex
Griffiths),„seashore paspalum" (Paspalum vaginatum Swartz) und„sideoats grama" (Bouteloua curtipendula (Michx. Torr.). "Cool season turfgrasses" sind für die erfindungsgemäße Verwendung im Allgemeinen bevorzugt. Besonders bevorzugt sind Blaugras, Straussgras und„redtop", Schwingel und Lolch. Straussgras ist Griffiths), seashore paspalum (Paspalum vaginatum Swartz) and sideoats grama (Bouteloua curtipendula (Michx.Torr.). "Cool season turfgrasses" are generally preferred for use in the invention.) Bleach grass, ostrich grass and "redtop ", Schwingel and Lolch
insbesondere bevorzugt. especially preferred.
Besonders bevorzugt werden erfindungsgemäß Pflanzen der jeweils handelsüblichen oder in Gebrauch befindlichen Pflanzensorten behandelt. Unter Pflanzensorten versteht man Pflanzen mit neuen Eigenschaften ("Traits"), die sowohl durch It is particularly preferred according to the invention to treat plants of the respective commercially available or in use plant cultivars. Plant varieties are understood to be plants with new properties ("traits"), both through
konventionelle Züchtung, durch Mutagenese oder mit Hilfe rekombinanter DNA- Techniken, gezüchtet worden sind. Kulturpflanzen können demnach Pflanzen sein, die durch konventionelle Züchtungs- und Optimierungsmethoden oder durch biotechnologische und gentechnologische Methoden oder Kombinationen dieser Methoden erhalten werden können, einschließlich der transgenen Pflanzen und einschließlich der durch Sortenschutzrechte schützbaren oder nicht schützbaren Pflanzensorten. conventional breeding, by mutagenesis or by recombinant DNA techniques. Crop plants can therefore be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant varieties protectable or non-protectable plant varieties.
Das erfindungsgemäße Behandlungsverfahren kann somit auch für die Behandlung von genetisch modifizierten Organismen (GMOs), z. B. Pflanzen oder Samen, verwendet werden. Genetisch modifizierte Pflanzen (oder transgene Pflanzen) sind Pflanzen, bei denen ein heterologes Gen stabil in das Genom integriert worden ist. Der Begriff "heterologes Gen" bedeutet im wesentlichen ein Gen, das außerhalb der Pflanze bereitgestellt oder assembliert wird und das bei Einführung in das The treatment method according to the invention can thus also for the treatment of genetically modified organisms (GMOs), z. As plants or seeds are used. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene has been stably integrated into the genome. The term "heterologous gene" essentially means a gene that is provided or assembled outside the plant and that when introduced into the plant
Zellkerngenom, das Chloroplastengenom oder das Hypochondriengenom der transformierten Pflanze dadurch neue oder verbesserte agronomische oder sonstige Eigenschaften verleiht, dass es ein interessierendes Protein oder Polypeptid exprimiert oder dasses ein anderes Gen, das in der Pflanze vorliegt bzw. andere Gene, die in der Pflanze vorliegen, herunterreguliert oder abschaltet (zum Beispiel mittels Antisense- Technologie, Co-suppressionstechnologie oder RNAi-Technologie [RNA Interference]). Ein heterologes Gen, das im Genom vorliegt, wird ebenfalls als Transgen bezeichnet. Ein Transgen, das durch sein spezifisches Vorliegen im Pflanzengenom definiert ist, wird als Transformations- bzw. transgenes Event bezeichnet. Nuclear genome, the chloroplast genome or the hypochondrial genome of the transformed plant thereby conferring new or improved agronomic or other properties by expressing a protein or polypeptide of interest or that it downregulates or shuts down another gene present in the plant or other genes present in the plant (for example, by antisense technology, co-suppression technology or RNAi technology [RNA Interference]). A heterologous gene present in the genome is also referred to as a transgene. A transgene defined by its specific presence in the plant genome is referred to as a transformation or transgenic event.
Zu Pflanzen und Pflanzensorten, die vorzugsweise erfindungsgemäß behandelt werden, zählen alle Pflanzen, die über Erbgut verfügen, das diesen Pflanzen Plants and plant varieties that are preferably treated according to the invention include all plants which have genetic material that these plants
besonders vorteilhafte, nützliche Merkmale verleiht (egal, ob dies durch Züchtung und/oder Biotechnologie erzielt wurde). gives particularly advantageous, useful features (regardless of whether this was achieved through breeding and / or biotechnology).
Pflanzen und Pflanzensorten, die ebenfalls erfindungsgemäß behandelt werden können, sind solche Pflanzen, die gegen einen oder mehrere abiotische Stressfaktoren resistent sind. Zu den abiotischen Stressbedingungen können zum Beispiel Dürre, Kälte- und Hitzebedingungen, osmotischer Stress, Staunässe, erhöhter Plants and plant varieties which can also be treated according to the invention are those plants which are resistant to one or more abiotic stress factors. For example, drought, cold and heat conditions, osmotic stress, waterlogging, elevated water levels, etc. can all contribute to abiotic stress
Bodensalzgehalt, erhöhtes Ausgesetztsein an Mineralien, Ozonbedingungen, Soil salt content, increased exposure to minerals, ozone conditions,
Starklichtbedingungen, beschränkte Verfügbarkeit von Stickstoffnährstoffen, High light conditions, limited availability of nitrogen nutrients,
beschränkte Verfügbarkeit von Phosphornährstoffen oder Vermeidung von Schatten zählen. limited availability of phosphorous nutrients or avoidance of shadows.
Pflanzen und Pflanzensorten, die ebenfalls erfindungsgemäß behandelt werden können, sind solche Pflanzen, die durch erhöhte Ertragseigenschaften gekennzeichnet sind. Ein erhöhter Ertrag kann bei diesen Pflanzen z. B. auf verbesserter Plants and plant varieties which can also be treated according to the invention are those plants which are characterized by increased yield properties. An increased yield can in these plants z. B. on improved
Pflanzenphysiologie, verbessertem Pflanzenwuchs und verbesserter Plant physiology, improved plant growth and improved
Pflanzenentwicklung, wie Wasserverwertungseffizienz, Wasserhalteeffizienz, verbesserter Stickstoffverwertung, erhöhter Kohlenstoffassimilation, verbesserter Photosynthese, verstärkter Keimkraft und beschleunigter Abreife beruhen. Der Ertrag kann weiterhin durch eine verbesserte Pflanzenarchitektur (unter Stress- und nicht- Stress-Bedingungen) beeinflußt werden, darunter frühe Blüte, Kontrolle der Blüte für die Produktion von Hybridsaatgut, Keimpflanzenwüchsigkeit, Pflanzengröße,  Plant development, such as water utilization efficiency, water retention efficiency, improved nitrogen utilization, increased carbon assimilation, improved photosynthesis, increased germination power and accelerated Abreife based. The yield may be further influenced by improved plant architecture (under stress and non-stress conditions), including early flowering, control of flowering for hybrid seed production, seedling vigor, plant size,
Internodienzahl und -abstand, Wurzelwachstum, Samengröße, Fruchtgröße, Internode number and distance, root growth, seed size, fruit size,
Schotengröße, Schoten- oder Ährenzahl, Anzahl der Samen pro Schote oder Ähre, Samenmasse, verstärkte Samenfüllung, verringerter Samenausfall, verringertes Schotenplatzen sowie Standfestigkeit. Zu weiteren Ertragsmerkmalen zählen Pod size, pod or ear number, number of seeds per pod or ear, seed mass, increased seed filling, decreased seed drop, decreased Pod popping and stability. Other income characteristics include
Samenzusammensetzung wie Kohlenhydratgehalt, Proteingehalt, Ölgehalt und Seed composition such as carbohydrate content, protein content, oil content and
Ölzusammensetzung, Nährwert, Verringerung der nährwidrigen Verbindungen, verbesserte Verarbeitbarkeit und verbesserte Lagerfähigkeit. Oil composition, nutritional value, reduction of nontoxic compounds, improved processability and improved shelf life.
Pflanzen, die erfindungsgemäß ebenfalls behandelt werden können, sind Plants which can also be treated according to the invention are
Hybridpflanzen, die bereits die Eigenschaften der Heterosis bzw. des Hybrideffekts exprimieren, was im allgemeinen zu höherem Ertrag, höherer Wüchsigkeit, besserer Gesundheit und besserer Resistenz gegen biotische und abiotische Stressfaktoren führt. Solche Pflanzen werden typischerweise dadurch erzeugt, dass man eine ingezüchtete pollensterile Elternlinie (den weiblichen Kreuzungspartner) mit einer anderen ingezüchteten pollenfertilen Elternlinie (dem männlichen Kreuzungspartner) kreuzt. Das Hybridsaatgut wird typischerweise von den pollensterilen Pflanzen geerntet und an Vermehrer verkauft. Pollensterile Pflanzen können manchmal (z. B. beim Mais) durch Entfahnen (d. h. mechanischem Entfernen der männlichen Hybrid plants that already express the properties of the heterosis or the hybrid effect, which generally leads to higher yield, higher vigor, better health and better resistance to biotic and abiotic stress factors. Such plants are typically produced by crossing an inbred male sterile parental line (the female crossover partner) with another inbred male fertile parent line (the male crossbred partner). The hybrid seed is typically harvested from the male sterile plants and sold to propagators. Pollen sterile plants can sometimes be removed (eg in maize) by delaving (i.e., mechanical removal of the males)
Geschlechtsorgane bzw. der männlichen Blüten), produziert werden; es ist jedoch üblicher, dass die Pollensterilität auf genetischen Determinanten im Pflanzengenom beruht. In diesem Fall, insbesondere dann, wenn es sich bei dem gewünschten Produkt, da man von den Hybridpflanzen ernten will, um die Samen handelt, ist es üblicherweise günstig, sicherzustellen, dass die Pollenfertilität in Hybridpflanzen, die die für die Pollensterilität verantwortlichen genetischen Determinanten enthalten, völlig restoriert wird. Dies kann erreicht werden, indem sichergestellt wird, dass die männlichen Kreuzungspartner entsprechende Fertilitätsrestorergene besitzen, die in der Lage sind, die Pollenfertilität in Hybridpflanzen, die die genetischen  Sex organs or the male flowers) are produced; however, it is more common for male sterility to be due to genetic determinants in the plant genome. In this case, especially when the desired product, as one wants to harvest from the hybrid plants, is the seeds, it is usually beneficial to ensure that the pollen fertility in hybrid plants containing the genetic determinants responsible for male sterility , completely restored. This can be achieved by ensuring that the male cross-breeding partners possess appropriate fertility restorer genes capable of controlling the pollen fertility in hybrid plants that are the genetic source
Determinanten, die für die Pollensterilität verantwortlich sind, enthalten, zu restorieren. Genetische Determinanten für Pollensterilität können im Cytoplasma lokalisiert sein. Beispiele für cytoplasmatische Pollensterilität (CMS) wurden zum Beispiel für Determinants responsible for the pollensity of the poll include restorative. Genetic determinants of pollen sterility may be localized in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have been reported, for example
Brassica-Arten beschrieben (WO 1992/005251 , WO 1995/009910, WO 1998/27806, WO 2005/002324, WO 2006/021972 und US 6,229,072). Genetische Determinanten für Pollensterilität können jedoch auch im Zellkerngenom lokalisiert sein. Pollensterile Pflanzen können auch mit Methoden der pflanzlichen Biotechnologie, wie Gentechnik, erhalten werden. Ein besonders günstiges Mittel zur Erzeugung von pollensterilen Pflanzen ist in WO 89/10396 beschrieben, wobei zum Beispiel eine Ribonuklease wie eine Barnase selektiv in den Tapetumzellen in den Staubblättern exprimiert wird. Die Fertilität kann dann durch Expression eines Ribonukleasehemmers wie Barstar in den Tapetumzellen restoriert werden (z. B. WO 1991/002069). Brassica species (WO 1992/005251, WO 1995/009910, WO 1998/27806, WO 2005/002324, WO 2006/021972 and US 6,229,072). However, genetic determinants of pollen sterility may also be localized in the nuclear genome. Pollen sterile plants can also be obtained using plant biotechnology methods such as genetic engineering. A particularly convenient means of producing male-sterile plants is described in WO 89/10396, wherein, for example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. The Fertility can then be restorated by expression of a ribonuclease inhibitor such as barstar in the tapetum cells (eg, WO 1991/002069).
Pflanzen oder Pflanzensorten (die mit Methoden der Pflanzenbiotechnologie, wie der Gentechnik, erhalten werden), die erfindungsgemäß ebenfalls behandelt werden können, sind herbizidtolerante Pflanzen, d. h. Pflanzen, die gegenüber einem oder mehreren vorgegebenen Herbiziden tolerant gemacht worden sind. Solche Pflanzen können entweder durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Herbizidtoleranz verleiht, erhalten werden. Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering) which can also be treated according to the invention are herbicide-tolerant plants, i. H. Plants tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation or by selection of plants containing a mutation conferring such herbicide tolerance.
Herbizidtolerante Pflanzen sind zum Beispiel glyphosatetolerante Pflanzen, d. h. Herbicide-tolerant plants are, for example, glyphosate-tolerant plants, i. H.
Pflanzen, die gegenüber dem Herbizid Glyphosate oder dessen Salzen tolerant gemacht worden sind. So können zum Beispiel glyphosatetolerante Pflanzen durch Transformation der Pflanze mit einem Gen, das für das Enzym 5-Enolpyruvylshikimat- 3-phosphatsynthase (EPSPS) kodiert, erhalten werden. Beispiele für solche EPSPS- Gene sind das AroA-Gen (Mutante CT7) des Bakteriums Salmonella typhimurium (Comai et al., Science (1983), 221 , 370-371 ), das CP4-Gen des Bakteriums Plants tolerant to the herbicide glyphosate or its salts. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium
Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), die Gene, die für eine EPSPS aus der Petunie (Shah et al., Science (1986), 233, 478- 481 ), für eine EPSPS aus der Tomate (Gasser et al., J. Biol. Chem. (1988), 263, 4280- 4289) oder für eine EPSPS aus Eleusine (WO 2001/66704) kodieren. Es kann sich auch um eine mutierte EPSPS handeln, wie sie zum Beispiel in EP-A 0837944, WO 2000/066746, WO 2000/066747 oder WO 2002/026995 beschrieben ist. Agrobacterium sp. (Barry et al., Curr Topics Plant Physiol. (1992), 7, 139-145), the genes responsible for petunia EPSPS (Shah et al., Science (1986), 233, 478-481). , for an EPSPS from the tomato (Gasser et al., J. Biol. Chem. (1988), 263, 4280- 4289) or for an EPSPS from Eleusine (WO 2001/66704) encode. It can also be a mutated EPSPS, as described, for example, in EP-A 0837944, WO 2000/066746, WO 2000/066747 or WO 2002/026995.
Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man ein Gen exprimiert, das für ein Glyphosate-Oxidoreduktase-Enzym, wie es in US Glyphosate-tolerant plants can also be obtained by expressing a gene encoding a glyphosate oxidoreductase enzyme as described in US Pat
5,776,760 und US 5,463,175 beschrieben ist, kodiert. Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass man ein Gen exprimiert, das für ein Glyphosate-acetyltransferase-Enzym, wie es in z. B. WO 2002/036782, WO  5,776,760 and US 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene encoding a glyphosate acetyltransferase enzyme as described in e.g. WO 2002/036782, WO
2003/092360, WO 2005/012515 und WO 2007/024782 beschrieben ist, kodiert. 2003/092360, WO 2005/012515 and WO 2007/024782.
Glyphosatetolerante Pflanzen können auch dadurch erhalten werden, dass manGlyphosate-tolerant plants can also be obtained by
Pflanzen, die natürlich vorkommende Mutationen der oben erwähnten Gene, wie sie zum Beispiel in WO 2001/024615 oder WO 2003/013226 beschrieben sind, enthalten, selektiert. Sonstige herbizidresistente Pflanzen sind zum Beispiel Pflanzen, die gegenüber Herbiziden, die das Enzym Glutaminsynthase hemmen, wie Bialaphos, Phosphinotricin oder Glufosinate, tolerant gemacht worden sind. Solche Pflanzen können dadurch erhalten werden, dass man ein Enzym exprimiert, das das Herbizid oder eine Mutante des Enzyms Glutaminsynthase, das gegenüber Hemmung resistent ist, entgiftet. Solch ein wirksames entgiftendes Enzym ist zum Beispiel ein Enzym, das für ein Plants which comprise naturally occurring mutations of the abovementioned genes, as described, for example, in WO 2001/024615 or WO 2003/013226. Other herbicide-resistant plants are, for example, plants which have been tolerated to herbicides which inhibit the enzyme glutamine synthase, such as bialaphos, phosphinotricin or glufosinate. Such plants can be obtained by expressing an enzyme which detoxifies the herbicide or a mutant of the enzyme glutamine synthase, which is resistant to inhibition. Such an effective detoxifying enzyme is, for example, an enzyme suitable for
Phosphinotricin-acetyltransferase kodiert (wie zum Beispiel das bar- oder pat-Protein aus Streptomyces-Arten). Pflanzen, die eine exogene Phosphinotricin- acetyltransferase exprimieren, sind zum Beispiel in US 5,561 ,236; US 5,648,477; US 5,646,024; US 5,273,894; US 5,637,489; US 5,276,268; US 5,739,082; US 5,908,810 und US 7,1 12,665 beschrieben. Phosphinotricin acetyltransferase encoded (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinotricin acetyltransferase are described, for example, in US 5,561,236; US 5,648,477; US 5,646,024; US 5,273,894; US 5,637,489; US 5,276,268; US 5,739,082; US 5,908,810 and US 7,112,665.
Weitere herbizidtolerante Pflanzen sind auch Pflanzen, die gegenüber den Herbiziden, die das Enzym Hydroxyphenylpyruvatdioxygenase (HPPD) hemmen, tolerant gemacht worden sind. Bei den Hydroxyphenylpyruvatdioxygenasen handelt es sich um Enzyme, die die Reaktion, in der para-Hydroxyphenylpyruvat (HPP) zu Homogentisat umgesetzt wird, katalysieren. Pflanzen, die gegenüber HPPD-Hemmern tolerant sind, können mit einem Gen, das für ein natürlich vorkommendes resistentes HPPD-Enzym kodiert, oder einem Gen, das für ein mutiertes HPPD-Enzym gemäß WO 1996/038567, WO 1999/024585 und WO 1999/024586 kodiert, transformiert werden. Eine Toleranz gegenüber HPPD-Hemmern kann auch dadurch erzielt werden, dass man Pflanzen mit Genen transformiert, die für gewisse Enzyme kodieren, die die Bildung von Further herbicide-tolerant plants are also plants tolerant to the herbicides which inhibit the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). The hydroxyphenylpyruvate dioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is converted to homogentisate. Plants tolerant to HPPD inhibitors may be treated with a gene encoding a naturally occurring resistant HPPD enzyme or a gene encoding a mutant HPPD enzyme according to WO 1996/038567, WO 1999/024585 and WO 1999 / 024586, are transformed. Tolerance to HPPD inhibitors can also be achieved by transforming plants with genes encoding certain enzymes that promote the formation of HPPD inhibitors
Homogentisat trotz Hemmung des nativen HPPD-Enzyms durch den HPPD-Hemmer ermöglichen. Solche Pflanzen und Gene sind in WO 1999/034008 und WO Allow homogentisate despite inhibition of the native HPPD enzyme by the HPPD inhibitor. Such plants and genes are described in WO 1999/034008 and WO
2002/36787 beschrieben. Die Toleranz von Pflanzen gegenüber HPPD-Hemmern kann auch dadurch verbessert werden, dass man Pflanzen zusätzlich zu einem Gen, das für ein HPPD-tolerantes Enzym kodiert, mit einem Gen transformiert, das für ein Prephenatdehydrogenase-Enzym kodiert, wie dies in WO 2004/024928 beschrieben ist. 2002/36787 described. The tolerance of plants to HPPD inhibitors can also be improved by transforming plants in addition to a gene coding for an HPPD-tolerant enzyme with a gene coding for a prephenate dehydrogenase enzyme, as described in WO 2004 / 024928 is described.
Weitere herbizidresistente Pflanzen sind Pflanzen, die gegenüber Acetolactatsynthase (ALS)-Hemmern tolerant gemacht worden sind. Zu bekannten ALS-Hemmern zählen zum Beispiel Sulfonylharnstoff, Imidazolinon, Triazolopyrimidine, Other herbicide-resistant plants are plants that have been tolerated to acetolactate synthase (ALS) inhibitors. Examples of known ALS inhibitors include sulfonylurea, imidazolinone, triazolopyrimidines,
Pyrimidinyloxy(thio)benzoate und/oder Sulfonylaminocarbonyltriazolinon-Herbizide. Es ist bekannt, dass verschiedene Mutationen im Enzym ALS (auch als Pyrimidinyloxy (thio) benzoates and / or sulfonylaminocarbonyltriazolinone herbicides. It It is known that various mutations in the enzyme ALS (also known as
Acetohydroxysäure-Synthase, AHAS, bekannt) eine Toleranz gegenüber Acetohydroxy acid synthase, AHAS, known) a tolerance to
unterschiedlichen Herbiziden bzw. Gruppen von Herbiziden verleihen, wie dies zum Beispiel bei Tranel und Wright, Weed Science (2002), 50, 700-712, jedoch auch in US 5,605,01 1 , US 5,378,824, US 5,141 ,870 und US 5,013,659, beschrieben ist. Die Herstellung von sulfonylharnstofftoleranten Pflanzen und imidazolinontoleranten Pflanzen ist in US 5,605,01 1 ; US 5,013,659; US 5,141 ,870; US 5,767,361 ; different herbicides or groups of herbicides, as described, for example, by Tranel and Wright, Weed Science (2002), 50, 700-712, but also in US Pat. Nos. 5,605,011, 5,378,824, 5,141,870 and 5,013,659. is described. The preparation of sulfonylurea tolerant plants and imidazolinone tolerant plants is described in US 5,605,011 1; US 5,013,659; US 5,141,870; US 5,767,361;
US 5,731 ,180; US 5,304,732; US 4,761 ,373; US 5,331 ,107; US 5,928,937; und US 5,731,180; US 5,304,732; US 4,761,373; US 5,331, 107; US 5,928,937; and
US 5,378,824; sowie in der internationalen Veröffentlichung WO 1996/033270 beschrieben. Weitere imidazolinontolerante Pflanzen sind auch in z. B. US 5,378,824; as well as in international publication WO 1996/033270. Other imidazolinontolerante plants are also in z. B.
WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093,  WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093,
WO 2006/007373, WO 2006/015376, WO 2006/024351 und WO 2006/060634 beschrieben. Weitere Sulfonylharnstoff- und imidazolinontolerante Pflanzen sind auch in z.B. WO 2007/024782 beschrieben. WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO 2006/060634. Other sulfonylurea and imidazolinone tolerant plants are also disclosed in e.g. WO 2007/024782 described.
Weitere Pflanzen, die gegenüber Imidazolinon und/oder Sulfonylharnstoff tolerant sind, können durch induzierte Mutagenese, Selektion in Zellkulturen in Gegenwart des Herbizids oder durch Mutationszüchtung erhalten werden, wie dies zum Beispiel für die Sojabohne in US 5,084,082, für Reis in WO 1997/41218, für die Zuckerrübe in US 5,773,702 und WO 1999/057965, für Salat in US 5,198,599 oder für die Sonnenblume in WO 2001/065922 beschrieben ist. Other plants which are tolerant to imidazolinone and / or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or by mutation breeding, as for example for the soybean in US 5,084,082, for rice in WO 1997/41218, for the sugar beet in US 5,773,702 and WO 1999/057965, for salad in US 5,198,599 or for the sunflower in WO 2001/065922.
Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls erfindungsgemäß behandelt werden können, sind insektenresistente transgene Pflanzen, d.h. Pflanzen, die gegen Befall mit gewissen Zielinsekten resistent gemacht wurden. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Insektenresistenz verleiht, erhalten werden. Der Begriff "insektenresistente transgene Pflanze" umfaßt im vorliegenden Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are insect-resistant transgenic plants, i. Plants that have been made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation or by selection of plants containing a mutation conferring such insect resistance. The term "insect-resistant transgenic plant" as used herein
Zusammenhang jegliche Pflanze, die mindestens ein Transgen enthält, das eine Kodiersequenz umfaßt, die für folgendes kodiert: 1 ) ein Insektizides Kristallprotein aus Bacillus thuringiensis oder einen Insektiziden Teil davon, wie die Insektiziden Kristallproteine, die von Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, zusammengestellt wurden, von Crickmore et al. (2005) in der Bacillus thuringiensis-Toxinnomenklatur aktualisiert (online bei: Relates to any plant containing at least one transgene comprising a coding sequence coding for: 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins collected by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature (online at:
http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), oder Insektizide Teile davon, z.B. Proteine der Cry-Proteinklassen CrylAb, CrylAc, Cryl F, Cry2Ab, Cry3Ae oder Cry3Bb oder Insektizide Teile davon; oder 2) ein Kristallprotein aus Bacillus thuringiensis oder einen Teil davon, der inhttp://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal parts thereof, e.g. Proteins of Cry protein classes CrylAb, CrylAc, Cryl F, Cry2Ab, Cry3Ae or Cry3Bb or insecticidal parts thereof; or 2) a crystal protein from Bacillus thuringiensis or a part thereof which is present in
Gegenwart eines zweiten, anderen Kristallproteins als Bacillus thuringiensis oder eines Teils davon insektizid wirkt, wie das binäre Toxin, das aus den Kristallproteinen Cy34 und Cy35 besteht (Moellenbeck et al., Nat. Biotechnol. (2001 ), 19, 668-72; Schnepf et al., Applied Environm. Microb. (2006), 71 , 1765-1774); oder Presence of a second, different crystal protein than Bacillus thuringiensis or a part thereof is insecticidal, such as the binary toxin consisting of the crystal proteins Cy34 and Cy35 (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environment Microb. (2006) 71, 1765-1774); or
3) ein Insektizides Hybridprotein, das Teile von zwei unterschiedlichen Insektiziden Kristallproteinen aus Bacillus thuringiensis umfaßt, wie zum Beispiel ein Hybrid aus den Proteinen von 1 ) oben oder ein Hybrid aus den Proteinen von 2) oben, z. B. das Protein Cry1A.105, das von dem Mais-Event MON98034 produziert wird (WO 3) an insecticidal hybrid protein comprising parts of two different insecticides of Bacillus thuringiensis crystal proteins, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g. For example, the protein Cry1A.105 produced by the corn event MON98034 (WO
2007/027777); oder 2007/027777); or
4) ein Protein gemäß einem der Punkte 1 ) bis 3) oben, in dem einige, 4) a protein according to any one of items 1) to 3) above, in which some,
insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere Insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier- DNA während der Klonierung oder Transformation induziert wurden, wie das Protein Cry3Bb1 in Mais-Events MON863 oder MON88017 oder das Protein Cry3A im Mais-Event MIR 604; oder 5) ein Insektizides sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus oder einen Insektiziden Teil davon, wie die vegetativ wirkenden In particular, 1 to 10, amino acids have been replaced by another amino acid to achieve higher insecticidal activity against a target insect species and / or to broaden the spectrum of the corresponding target insect species and / or due to changes in the coding DNA during cloning or Transformation were induced, such as the protein Cry3Bb1 in maize events MON863 or MON88017 or the protein Cry3A in the maize event MIR 604; or 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus or an insecticidal part thereof, such as the vegetative
insektentoxischen Proteine (vegetative insecticidal proteins, VIP), die unter folgendem Link angeführt sind, z. B. Proteine der Proteinklasse VIP3Aa: insecticidal proteins (VIP) listed under the following link, e.g. B. Proteins of protein class VIP3Aa:
http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html oder 6) ein sezerniertes Protein aus Bacillus thuringiensis oder Bacillus cereus, das in Gegenwart eines zweiten sezernierten Proteins aus Bacillus thuringiensis oder B. cereus insektizid wirkt, wie das binäre Toxin, das aus den Proteinen VIP1A und VIP2A besteht (WO 1994/21795); oder http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/vip.html or 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin consisting of the proteins VIP1A and VIP2A (WO 1994/21795); or
7) ein Insektizides Hybridprotein, das Teile von verschiedenen sezernierten Proteinen von Bacillus thuringiensis oder Bacillus cereus umfaßt, wie ein Hybrid der Proteine von 1 ) oder ein Hybrid der Proteine von 2) oben; oder 7) an insecticidal hybrid protein comprising parts of various secreted proteins of Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins of 1) or a hybrid of the proteins of 2) above; or
8) ein Protein gemäß einem der Punkte 1 ) bis 3) oben, in dem einige, 8) a protein according to any one of items 1) to 3) above, in which some,
insbesondere 1 bis 10, Aminosäuren durch eine andere Aminosäure ersetzt wurden, um eine höhere Insektizide Wirksamkeit gegenüber einer Zielinsektenart zu erzielen und/oder um das Spektrum der entsprechenden Zielinsektenarten zu erweitern und/oder wegen Veränderungen, die in die Kodier- DNA während der Klonierung oder Transformation induziert wurden (wobei die Kodierung für ein Insektizides Protein erhalten bleibt), wie das Protein VIP3Aa im Baumwoll-Event COT 102. In particular, 1 to 10, amino acids have been replaced by another amino acid to achieve higher insecticidal activity against a target insect species and / or to broaden the spectrum of the corresponding target insect species and / or due to changes in the coding DNA during cloning or Transformation (retaining coding for an insecticidal protein) such as protein VIP3Aa in cotton event COT 102.
Natürlich zählt zu den insektenresistenten transgenen Pflanzen im vorliegenden Zusammenhang auch jegliche Pflanze, die eine Kombination von Genen umfaßt, die für die Proteine von einer der oben genannten Klassen 1 bis 8 kodieren. In einer Ausführungsform enthält eine insektenresistente Pflanze mehr als ein Transgen, das für ein Protein nach einer der oben genannten 1 bis 8 kodiert, um das Spektrum der entsprechenden Zielinsektenarten zu erweitern oder um die Entwicklung einer Of course, insect-resistant transgenic plants in the present context also include any plant comprising a combination of genes encoding the proteins of any of the above classes 1 to 8. In one embodiment, an insect resistant plant contains more than one transgene encoding a protein of any one of the above 1 to 8 in order to extend the spectrum of the corresponding target insect species or to develop a protein
Resistenz der Insekten gegen die Pflanzen dadurch hinauszuzögern, dass man verschiedene Proteine einsetzt, die für dieselbe Zielinsektenart insektizid sind, jedoch eine unterschiedliche Wirkungsweise, wie Bindung an unterschiedliche To delay insect resistance to plants by using different proteins which are insecticidal for the same target insect species, but a different mode of action, such as binding to different ones
Rezeptorbindungsstellen im Insekt, aufweisen. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls erfindungsgemäß behandelt werden können, sind gegenüber abiotischen Stressfaktoren tolerant. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solch eine Stressresistenz verleiht, erhalten werden. Zu besonders nützlichen Pflanzen mit Stresstoleranz zählen folgende: a. Pflanzen, die ein Transgen enthalten, das die Expression und/oder Aktivität des Gens für die Poly(ADP-ribose)polymerase (PARP) in den Pflanzenzellen oder Receptor binding sites in the insect. Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering), which can also be treated according to the invention, are tolerant to abiotic stressors. Such plants can be transformed by genetic transformation or by selection of plants that have a mutation containing such a stress resistance can be obtained. Particularly useful plants with stress tolerance include the following: a. Plants which contain a transgene which have the expression and / or activity of the gene for the poly (ADP-ribose) polymerase (PARP) in the plant cells or
Pflanzen zu reduzieren vermag, wie dies in WO 2000/004173 oder EP 04077984.5 oder EP 06009836.5 beschrieben ist. b. Pflanzen, die ein stresstoleranzförderndes Transgen enthalten, das die  To reduce plants, as described in WO 2000/004173 or EP 04077984.5 or EP 06009836.5. b. Plants that contain a stress tolerance enhancing transgene that the
Expression und/oder Aktivität der für PARG kodierenden Gene der Pflanzen oder Pflanzenzellen zu reduzieren vermag, wie dies z.B. in WO 2004/090140 beschrieben ist; c. Pflanzen, die ein stresstoleranzförderndes Transgen enthalten, das für ein in Pflanzen funktionelles Enzym des Nicotinamidadenindinukleotid-Salvage-To reduce expression and / or activity of PARG-encoding genes of plants or plant cells, as described e.g. in WO 2004/090140 is described; c. Plants containing a stress tolerance enhancing transgene which is useful for a plant functional enzyme of the nicotinamide adenine dinucleotide salvage
Biosynthesewegs kodiert, darunter Nicotinamidase, Biosynthetic pathway, including nicotinamidase,
Nicotinatphosphoribosyltransferase, Nicotinsäuremononukleotid-adenyltransferase, Nicotinamidadenindinukleotidsynthetase oder Nicotinamidphosphoribosyl-transferase, wie dies z. B. in EP 04077624.7 oder WO 2006/133827 oder PCT/EP07/002433 beschrieben ist.  Nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyltransferase, nicotinamide adenine dinucleotide synthetase or nicotinamide phosphoribosyltransferase, as described e.g. As described in EP 04077624.7 or WO 2006/133827 or PCT / EP07 / 002433.
Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls erfindungsgemäß behandelt werden können, weisen eine veränderte Menge, Qualität und/oder Lagerfähigkeit des Plants or plant varieties (obtained by methods of plant biotechnology, such as genetic engineering), which can also be treated according to the invention, have a modified amount, quality and / or shelf life of the
Ernteprodukts und/oder veränderte Eigenschaften von bestimmten Bestandteilen des Ernteprodukts auf, wie zum Beispiel: Crop product and / or altered characteristics of certain components of the crop, such as:
1 ) Transgene Pflanzen, die eine modifizierte Stärke synthetisieren, die bezüglich ihrer chemisch-physikalischen Eigenschaften, insbesondere des Amylosegehalts oder des Amylose/Amylopektin-Verhältnisses, des Verzweigungsgrads, der 1) Transgenic plants that synthesize a modified starch, with respect to their chemical-physical properties, in particular the amylose content or the amylose / amylopectin ratio, the degree of branching, the
durchschnittlichen Kettenlänge, der Verteilung der Seitenketten, des average chain length, the distribution of side chains, the
Viskositätsverhaltens, der Gelfestigkeit, der Stärkekorngröße und/oder Viscosity behavior, the gel strength, the starch grain size and / or
Stärkekornmorphologie im Vergleich mit der synthetisierten Stärke in Starch grain morphology in comparison with the synthesized starch in
Wildtyppflanzenzellen oder -pflanzen verändert ist, so dass sich diese modifizierte Stärke besser für bestimmte Anwendungen eignet. Diese transgenen Pflanzen, die eine modifizierte Stärke synthetisieren, sind zum Beispiel in EP 0571427, Wild-type plant cells or plants is altered so that these modified Strength better suited for specific applications. These transgenic plants which synthesize a modified starch are described, for example, in EP 0571427,
WO 1995/004826, EP 0719338, WO 1996/15248, WO 1996/19581 , WO 1996/27674, WO 1997/1 1 188, WO 1997/26362, WO 1997/32985, WO 1997/42328, WO WO 1995/004826, EP 0719338, WO 1996/15248, WO 1996/19581, WO 1996/27674, WO 1997/1 1 188, WO 1997/26362, WO 1997/32985, WO 1997/42328, WO
1997/44472, WO 1997/45545, WO 1998/27212, WO 1998/40503, WO 99/58688, WO 1999/58690, WO 1999/58654, WO 2000/008184, WO 2000/008185, WO 2000/28052, WO 2000/77229, WO 2001/12782, WO 2001/12826, WO 2002/101059, WO 1997/44472, WO 1997/45545, WO 1998/27212, WO 1998/40503, WO 99/58688, WO 1999/58690, WO 1999/58654, WO 2000/008184, WO 2000/008185, WO 2000/28052, WO 2000/77229, WO 2001/12782, WO 2001/12826, WO 2002/101059, WO
2003/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941 , WO 2003/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO
2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO
2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO
2007/009823, WO 2000/22140, WO 2006/063862, WO 2006/072603, WO 2007/009823, WO 2000/22140, WO 2006/063862, WO 2006/072603, WO
2002/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1 , EP 07090009.7, WO 2001/14569, WO 2002/79410, WO 2003/33540, WO 2004/078983, WO 2001/19975, WO 1995/26407, WO 1996/34968, WO 1998/20145, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 2001/14569, WO 2002/79410, WO 2003/33540, WO 2004/078983, WO 2001/19975, WO 1995/26407, WO 1996/34968, WO 1998/20145,
WO 1999/12950, WO 1999/66050, WO 1999/53072, US 6,734,341 , WO 2000/1 1 192, WO 1998/22604, WO 1998/32326, WO 2001/98509, WO 2001/98509, WO WO 1999/12950, WO 1999/66050, WO 1999/53072, US Pat. No. 6,734,341, WO 2000/1 1 192, WO 1998/22604, WO 1998/32326, WO 2001/98509, WO 2001/98509, WO
2005/002359, US 5,824,790, US 6,013,861 , WO 1994/004693, WO 1994/009144, WO 1994/1 1520, WO 1995/35026 bzw. WO 1997/20936 beschrieben. 2) Transgene Pflanzen, die Nichtstärkekohlenhydratpolymere synthetisieren, oder Nichtstärkekohlenhydratpolymere, deren Eigenschaften im Vergleich zu 2005/002359, US 5,824,790, US 6,013,861, WO 1994/004693, WO 1994/009144, WO 1994/1 1520, WO 1995/35026 and WO 1997/20936, respectively. 2) Transgenic plants that synthesize non-starch carbohydrate polymers, or non-starch carbohydrate polymers whose properties are compared to
Wildtyppflanzen ohne genetische Modifikation verändert sind. Beispiele sind Pflanzen, die Polyfructose, insbesondere des Inulin- und Levantyps, produzieren, wie dies in EP 0663956, WO 1996/001904, Wo 1996/021023, WO 1998/039460 und WO Wildtype plants are modified without genetic modification. Examples are plants which produce polyfructose, in particular of the inulin and levan type, as described in EP 0663956, WO 1996/001904, WO 1996/021023, WO 1998/039460 and WO
1999/024593 beschrieben ist, Pflanzen, die alpha-1 ,4-Glucane produzieren, wie dies in WO 1995/031553, US 2002/031826, US 6,284,479, US 5,712,107, WO 1997/047806, WO 1997/047807, WO 1997/047808 und WO 2000/14249 beschrieben ist, Pflanzen, die alpha-1 ,6-verzweigte alpha-1 ,4-Glucane produzieren, wie dies in WO 2000/73422 beschrieben ist, und Pflanzen, die Alternan produzieren, wie dies in WO 2000/047727, EP 06077301 .7, US 5,908,975 und EP 0728213 beschrieben ist. 1999/024593, plants which produce alpha-1, 4-glucans, as described in WO 1995/031553, US 2002/031826, US 6,284,479, US 5,712,107, WO 1997/047806, WO 1997/047807, WO 1997 / 047808 and WO 2000/14249, plants producing alpha-1, 6-branched alpha-1, 4-glucans as described in WO 2000/73422 and plants producing alternan, as described in WO 2000 / 047727, EP 06077301 .7, US 5,908,975 and EP 0728213.
3) Transgene Pflanzen, die Hyaluronan produzieren, wie dies zum Beispiel in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, 3) Transgenic plants which produce hyaluronan, as described, for example, in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316,
JP 2006/304779 und WO 2005/012529 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls erfindungsgemäß behandelt werden können, sind Pflanzen wie Baumwollpflanzen mit veränderten Fasereigenschaften. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solche veränderten Fasereigenschaften verleiht, erhalten werden; dazu zählen: a) Pflanzen wie Baumwollpflanzen, die eine veränderte Form von JP 2006/304779 and WO 2005/012529. Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering), which can also be treated according to the invention, are plants such as cotton plants with altered fiber properties. Such plants can be obtained by genetic transformation or by selection of plants containing a mutation conferring such altered fiber properties; These include: a) plants, such as cotton plants, which have an altered form of
Cellulosesynthasegenen enthalten, wie dies in WO 1998/000549 beschrieben ist, b) Pflanzen wie Baumwollpflanzen, die eine veränderte Form von rsw2- oder rsw3- homologen Nukleinsäuren enthalten, wie dies in WO 2004/053219 beschrieben ist; c) Pflanzen wie Baumwollpflanzen mit einer erhöhten Expression der Cellulosesynthasegenen contain, as described in WO 1998/000549, b) plants such as cotton plants containing an altered form of rsw2 or rsw3 homologous nucleic acids, as described in WO 2004/053219; c) plants such as cotton plants with an increased expression of the
Saccharosephosphatsynthase, wie dies in WO 2001/017333 beschrieben ist; d) Pflanzen wie Baumwollpflanzen mit einer erhöhten Expression der Sucrose phosphate synthase as described in WO 2001/017333; d) plants such as cotton plants with an increased expression of
Saccharosesynthase, wie dies in WO 02/45485 beschrieben ist; e) Pflanzen wie Baumwollpflanzen bei denen der Zeitpunkt der Durchlaßsteuerung der Plasmodesmen an der Basis der Faserzelle verändert ist, z.B. durch Sucrose synthase as described in WO 02/45485; e) plants, such as cotton plants, where the timing of transmission control of the plasmodesms at the base of the fiber cell is changed, e.g. by
Herunterregulieren der faserselektiven ß-1 ,3-Glucanase, wie dies in WO 2005/017157 beschrieben ist; f) Pflanzen wie Baumwollpflanzen mit Fasern mit veränderter Reaktivität, z.B. durch Expression des N-Acetylglucosamintransferasegens, darunter auch nodC, und von Chitinsynthasegenen, wie dies in WO 2006/136351 beschrieben ist. Pflanzen oder Pflanzensorten (die nach Methoden der pflanzlichen Biotechnologie, wie der Gentechnik, erhalten wurden), die ebenfalls erfindungsgemäß behandelt werden können, sind Pflanzen wie Raps oder verwandte Brassica-Pflanzen mit veränderten Eigenschaften der Ölzusammensetzung. Solche Pflanzen können durch genetische Transformation oder durch Selektion von Pflanzen, die eine Mutation enthalten, die solche veränderten Öleigenschaften verleiht, erhalten werden; dazu zählen: a) Pflanzen wie Rapspflanzen, die Öl mit einem hohen Ölsäuregehalt produzieren, wie dies zum Beispiel in US 5,969,169, US 5,840,946 oder US 6,323,392 oder USDown-regulating the fiber-selective β-1,3-glucanase as described in WO 2005/017157; f) plants such as cotton plants with fibers with altered reactivity, for example by expression of the N-acetylglucosamine transferase gene, including nodC, and of chitin synthase genes, as described in WO 2006/136351. Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are plants such as oilseed rape or related Brassica plants with altered oil composition properties. Such plants can be caused by genetic Transformation or selection of plants containing a mutation conferring such altered oil properties; These include: a) plants such as rape plants that produce high oleic acid oil, as described, for example, in US 5,969,169, US 5,840,946 or US 6,323,392 or US
6,063, 947 beschrieben ist; b) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen Linolensäuregehalt produzieren, wie dies in US 6,270828, US 6,169,190 oder US 5,965,755 beschrieben ist. c) Pflanzen wie Rapspflanzen, die Öl mit einem niedrigen gesättigten 6,063,947; b) plants such as oilseed rape plants which produce low linolenic acid oil, as described in US 6,270,828, US 6,169,190 or US 5,965,755. c) plants such as rape plants, the oil with a low saturated
Fettsäuregehalt produzieren, wie dies z. B. in US 5,434,283 beschrieben ist. Besonders nützliche transgene Pflanzen, die erfindungsgemäß behandelt werden können, sind Pflanzen mit einem oder mehreren Genen, die für ein oder mehrere Toxine kodieren, sind die transgenen Pflanzen, die unter den folgenden Produce fatty acid content, as z. As described in US 5,434,283. Particularly useful transgenic plants which can be treated according to the invention are plants having one or more genes coding for one or more toxins, the transgenic plants being one of the following
Handelsbezeichnungen angeboten werden: YIELD GARD® (zum Beispiel Mais, Baumwolle, Sojabohnen), KnockOut® (zum Beispiel Mais), BiteGard® (zum Beispiel Mais), BT-Xtra® (zum Beispiel Mais), StarLink® (zum Beispiel Mais), Bollgard®Commercial names: YIELD GARD® (for example, corn, cotton, soybeans), KnockOut® (for example, corn), BiteGard® (for example, corn), BT-Xtra® (for example, corn), StarLink® (for example, corn) , Bollgard®
(Baumwolle), Nucotn® (Baumwolle), Nucotn 33B® (Baumwolle), NatureGard® (zum Beispiel Mais), Protecta® und NewLeaf® (Kartoffel). Herbizidtolerante Pflanzen, die zu erwähnen sind, sind zum Beispiel Maissorten, Baumwollsorten und Sojabohnensorten, die unter den folgenden Handelsbezeichnungen angeboten werden: Roundup Ready® (Glyphosatetoleranz, zum Beispiel Mais, Baumwolle, Sojabohne), Liberty Link® (Cotton), Nucotn® (cotton), Nucotn 33B® (cotton), NatureGard® (for example corn), Protecta® and NewLeaf® (potato). Herbicide-tolerant crops to be mentioned include, for example, corn, cotton and soybean varieties sold under the following tradenames: Roundup Ready® (glyphosate tolerance, for example corn, cotton, soybean), Liberty Link®
(Phosphinotricintoleranz, zum Beispiel Raps), IMI® (Imidazolinontoleranz) und SCS® (Sylfonylharnstofftoleranz), zum Beispiel Mais. Zu den herbizidresistenten Pflanzen (traditionell auf Herbizidtoleranz gezüchtete Pflanzen), die zu erwähnen sind, zählen die unter der Bezeichnung Clearfield® angebotenen Sorten (zum Beispiel Mais).  (Phosphinotricin tolerance, for example rapeseed), IMI® (imidazolinone tolerance) and SCS® (Sylfonylurea tolerance), for example maize. Herbicide-resistant plants (plants traditionally grown for herbicide tolerance) to be mentioned include the varieties sold under the name Clearfield® (for example corn).
Besonders nützliche transgene Pflanzen, die erfindungsgemäß behandelt werden können, sind Pflanzen, die Transformations-Events, oder eine Kombination von Transformations-Events, enthalten und die zum Beispiel in den Dateien von Particularly useful transgenic plants which can be treated according to the invention are plants, the transformation events, or a combination of Transformation events, included and which, for example, in the files of
verschiedenen nationalen oder regionalen Behörden angeführt sind. various national or regional authorities.
Die erfindungsgemäß zu verwendenden Verbindungen der allgemeinen Formel (I) können in üblichen Formulierungen überführt werden, wie Lösungen, Emulsionen, Spritzpulver, wasser- und ölbasierte Suspensionen, Pulver, Stäubemittel, Pasten, lösliche Pulver, lösliche Granulate, Streugranulate, Suspensions-Emulsions- Konzentrate, Wirkstoff-imprägnierte Naturstoffe, Wirkstoff-imprägnierte synthetische Stoffe, Düngemittel sowie Feinstverkapselungen in polymeren Stoffen. Im Rahmen der vorliegenden Erfindung ist es insbesondere bevorzugt, wenn die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) in der Form einer Sprühformulieruing verwendet werden. The compounds of the general formula (I) to be used according to the invention can be converted into customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, scattering granules, suspension emulsion concentrates , Active ingredient-impregnated natural substances, active substance-impregnated synthetic substances, fertilizers and ultrafine encapsulations in polymeric substances. In the context of the present invention, it is particularly preferred if the compounds of the general formula (I) according to the invention are used in the form of a spray formulation.
Die vorliegende Erfindung betrifft daher darüber hinaus auch eine Sprühformulierung zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischem Stress. Im Folgenden wird eine Sprühformulierung näher beschrieben: The present invention therefore further relates to a spray formulation for increasing the resistance of plants to abiotic stress. In the following, a spray formulation is described in more detail:
Die Formulierungen zur Sprühapplikation werden in bekannter Weise hergestellt, z.B. durch Vermischen der erfindungsgemäß zu verwendenden Verbindungen der allgemeinen Formel (I) mit Streckmitteln, also flüssigen Lösungsmitteln und/oder festen Trägerstoffen, gegebenenfalls unter Verwendung von oberflächenaktiven Mitteln, also Emulgiermitteln und/oder Dispergiermitteln und/oder schaumerzeugenden Mitteln. Weitere übliche Zusatzstoffe, wie zum Beispiel übliche Streckmittel sowie Lösungs- oder Verdünnungsmittel, Farbstoffe, Netzmittel, Dispergiermittel, The formulations for spray application are prepared in a known manner, e.g. by mixing the compounds of the general formula (I) to be used according to the invention with extenders, ie liquid solvents and / or solid carriers, if appropriate using surface-active agents, ie emulsifiers and / or dispersants and / or foam-forming agents. Further customary additives, such as, for example, customary extenders and solvents or diluents, dyes, wetting agents, dispersants,
Emulgatoren, Entschäumer, Konservierungsmittel, sekundäre Verdickungsmittel, Kleber, Gibberelline und auch Wasser, können gegebenenfalls auch verwendet werden. Die Herstellung der Formulierungen erfolgt entweder in geeigneten Anlagen oder auch vor oder während der Anwendung. Als Hilfsstoffe können solche Stoffe Verwendung finden, die geeignet sind, dem Mittel selbst oder und/oder davon abgeleitete Zubereitungen (z.B. Spritzbrühen) besondere Eigenschaften zu verleihen, wie bestimmte technische Eigenschaften und/oder auch besondere biologische Eigenschaften. Als typische Hilfsmittel kommen in Frage: Emulsifiers, defoamers, preservatives, secondary thickeners, adhesives, gibberellins, and also water may optionally be used. The preparation of the formulations is carried out either in suitable systems or before or during use. Excipients which can be used are those which are suitable for imparting special properties to the composition itself or to preparations derived therefrom (for example spray mixtures), such as certain technical properties and / or special biological properties. As typical aids are:
Streckmittel, Lösemittel und Trägerstoffe. Als Streckmittel eignen sich z.B. Wasser, polare und unpolare organische chemische Flüssigkeiten z.B. aus den Klassen der aromatischen und nicht-aromatischen Extenders, solvents and carriers. Suitable extenders include, for example, water, polar and non-polar organic chemical liquids, for example from the classes of aromatic and non-aromatic
Kohlenwasserstoffe (wie Paraffine, Alkylbenzole, Alkylnaphthaline, Chlorbenzole), der Alkohole und Polyole (die ggf. auch substituiert, verethert und/oder verestert sein können), der Ketone (wie Aceton, Cyclohexanon), Ester (auch Fette und Öle) und (Poly-)Ether, der einfachen und substituierten Amine, Amide, Lactame (wie N- Alkylpyrrolidone) und Lactone, der Sulfone und Sulfoxide (wie Dimethylsysulfoxid). Im Falle der Benutzung von Wasser als Streckmittel können z.B. auch organische Lösemittel als Hilfslösungsmittel verwendet werden. Als flüssige Lösemittel kommen im wesentlichen in Frage: Aromaten, wie Xylol, Toluol, oder Alkylnaphthaline, chlorierte Aromaten und chlorierte aliphatische Kohlenwasserstoffe, wie Chlorbenzole, Chlorethylene oder Methylenchlorid, aliphatische Kohlenwasserstoffe, wie Cyclohexan oder Paraffine, z.B. Erdölfraktionen, mineralische und pflanzliche Öle, Alkohole, wie Butanol oder Glykol sowie deren Ether und Ester, Ketone wie Aceton, Hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), alcohols and polyols (which may also be substituted, etherified and / or esterified), ketones (such as acetone, cyclohexanone), esters (including fats and oils) and ( Poly) ethers, simple and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, sulfones and sulfoxides (such as dimethyl sulfoxide). In the case of using water as an extender, e.g. also organic solvents can be used as auxiliary solvent. Suitable liquid solvents are essentially: aromatics, such as xylene, toluene, or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, e.g. Petroleum fractions, mineral and vegetable oils, alcohols, such as butanol or glycol, and their ethers and esters, ketones, such as acetone,
Methylethylketon, Methyl isobutylketon oder Cyclohexanon, stark polare Lösungsmittel, wie Dimethylsulfoxid, sowie Wasser. Es können Farbstoffe wie anorganische Pigmente, z.B. Eisenoxid, Titanoxid, Ferro- cyanblau und organische Farbstoffe, wie Alizarin-, Azo- und Metallphthalocyanin- farbstoffe und Spurennährstoffe wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink verwendet werden. Als Netzmittel, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle zur Formulierung von agrochemischen Wirkstoffen üblichen, die Benetzung fördernden Stoffe in Frage. Vorzugsweise verwendbar sind Alkylnaphthalin-Sulfonate, wie Diisopropyl- oder Diisobutylnaphthalin-Sulfonate. Als Dispergiermittel und/oder Emulgatoren, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle zur Formulierung von Methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strong polar solvents such as dimethyl sulfoxide, and water. Dyes such as inorganic pigments, e.g. Iron oxide, titanium oxide, ferrocyan blue and organic dyes such as alizarin, azo and metal phthalocyanine dyes and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc. Suitable wetting agents which may be present in the formulations which can be used according to the invention are all wetting-promoting substances customary for the formulation of agrochemical active compounds. Preferably usable are alkylnaphthalene sulfonates such as diisopropyl or diisobutylnaphthalene sulfonates. As dispersants and / or emulsifiers, which may be contained in the formulations usable according to the invention, all come to the formulation of
agrochemischen Wirkstoffen üblichen nichtionischen, anionischen und kationischen Dispergiermittel in Betracht. Vorzugsweise verwendbar sind nichtionische oder anionische Dispergiermittel oder Gemische von nichtionischen oder anionischen Dispergiermitteln. Als geeignete nichtionische Dispergiermittel sind insbesondere Ethylenoxid-Propylenoxid-Blockpolymere, Alkylphenolpolyglykolether sowie agrochemical active ingredients conventional nonionic, anionic and cationic dispersants into consideration. Preferably used are nonionic or anionic dispersants or mixtures of nonionic or anionic Dispersants. Suitable nonionic dispersants are in particular ethylene oxide-propylene oxide block polymers, alkylphenol polyglycol ethers and
Tristryrylphenolpolyglykolether und deren phosphatierte oder sulfatierte Derivate zu nennen. Geeignete anionische Dispergiermittel sind insbesondere Ligninsulfonate, Polyacrylsäuresalze und Arylsulfonat-Formaldehydkondensate. Tristryrylphenolpolyglykolether and their phosphated or sulfated derivatives. Suitable anionic dispersants are in particular lignosulfonates, polyacrylic acid salts and arylsulfonate-formaldehyde condensates.
Als Entschäumer können in den erfindungsgemäß verwendbaren Formulierungen alle zur Formulierung von agrochemischen Wirkstoffen üblichen schaumhemmenden Stoffe enthalten sein. Vorzugsweise verwendbar sind Silikonentschäumer und Defoamers which may be present in the formulations which can be used according to the invention are all foam-inhibiting substances customary for the formulation of agrochemical active compounds. Preferably usable are silicone defoamers and
Magnesiumstearat. Magnesium stearate.
Als Konservierungsmittel können in den erfindungsgemäß verwendbaren As preservatives can be used in the invention
Formulierungen alle für derartige Zwecke in agrochemischen Mitteln einsetzbaren Stoffe vorhanden sein. Beispielhaft genannt seien Dichlorophen und Formulations all substances that can be used for such purposes in agrochemical agents be present. Examples include dichlorophen and
Benzylalkoholhemiformal. Benzyl alcohol.
Als sekundäre Verdickungsmittel, die in den erfindungsgemäß verwendbaren As secondary thickening agents, which can be used in the invention
Formulierungen enthalten sein können, kommen alle für derartige Zwecke in agrochemischen Mitteln einsetzbaren Stoffe in Frage. Vorzugsweise in Betracht kommen Cellulosederivate, Acrylsäurederivate, Xanthan, modifizierte Tone und hochdisperse Kieselsäure. Formulations may be included, are all usable for such purposes in agrochemical agents substances. Preference is given to cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and finely divided silica.
Als Kleber, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen alle üblichen in Beizmitteln einsetzbaren Bindemittel in Frage. Suitable adhesives which may be present in the formulations which can be used according to the invention are all customary binders which can be used in pickling agents.
Vorzugsweise genannt seien Polyvinylpyrrolidon, Polyvinylacetat, Polyvinylalkohol und Tylose. Als Gibberelline, die in den erfindungsgemäß verwendbaren Formulierungen enthalten sein können, kommen vorzugsweise die Gibberelline A1 , A3 (= Preferably mentioned are polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and Tylose. As gibberellins which may be present in the formulations which can be used according to the invention, the gibberellins A1, A3 (=
Gibberellinsäure), A4 und A7 infrage, besonders bevorzugt verwendet man die Gibberellinsäure. Die Gibberelline sind bekannt (vgl. R. Wegler„Chemie der Gibberellic acid), A4 and A7, most preferably using gibberellic acid. The gibberellins are known (see R. Wegler "Chemie der
Pflanzenschutz- und Schädlingsbekämpfungsmittel", Bd. 2, Springer Verlag, 1970, S. 401 -412). Phytosanitary and Pesticides ", Vol. 2, Springer Verlag, 1970, pp. 401-412).
Weitere Additive können Duftstoffe, mineralische oder vegetabilische gegebenenfalls modifizierte Öle, Wachse und Nährstoffe (auch Spurennährstoffe), wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink sein. Weiterhin enthalten sein können Stabilisatoren wie Kältestabilisatoren, Oxidationsschutzmittel, Lichtschutzmittel oder andere die chemische und / oder physikalische Stabilität verbessernde Mittel. Die Formulierungen enthalten im Allgemeinen zwischen 0,01 und 98 Gew.-%, vorzugsweise zwischen 0,5 und 90 %, der Verbindung der allgemeinen Formel (I). Other additives may be fragrances, mineral or vegetable optionally modified oils, waxes and nutrients (including micronutrients), such as salts of Iron, manganese, boron, copper, cobalt, molybdenum and zinc. Stabilizers such as cold stabilizers, antioxidants, light stabilizers or other chemical and / or physical stability improving agents may also be included. The formulations generally contain between 0.01 and 98% by weight, preferably between 0.5 and 90%, of the compound of general formula (I).
Der erfindungsgemäße Wirkstoff kann in seinen handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischung mit anderen Wirkstoffen wie Insektiziden, Lockstoffen, Sterilantien, Bakteriziden, Akari- ziden, Nematiziden, Fungiziden, wachstumsregulierenden Stoffen, Herbiziden, The active substance according to the invention can be used in its commercially available formulations as well as in the formulations prepared from these formulations in admixture with other active ingredients such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth-regulating substances, herbicides,
Safenern, Düngemitteln oder Semiochemicals vorliegen. Safeners, fertilizers or semiochemicals.
Ferner lässt sich die beschriebene positive Wirkung der Verbindungen der Furthermore, the described positive effect of the compounds of the
allgemeinden Formel (I) auf die pflanzeneigenen Abwehrkräfte durch eine zusätzliche Behandlung mit insektziden, fungiziden oder bakteriziden Wirkstoffen unterstützen. general formula (I) to support the plant's own defenses by additional treatment with insecticidal, fungicidal or bactericidal agents.
Bevorzugte Zeitpunkte für die Applikation von Verbindungen der allgemeinen Formel (I) zur Seigerung der Resistanz gegenüber abiotischem Stress sind Boden-, Stamm- und/oder Blattbehandlungen mit den zugelassenen Aufwandmengen. Preferred times for the application of compounds of the general formula (I) for the seizure of the resistance to abiotic stress are soil, stem and / or leaf treatments with the permitted application rates.
Die erfindungsgemäßen Verbindungen der allgemeinen Formel (I) können im The compounds of general formula (I) according to the invention can be described in
Allgemeinen darüber hinaus in ihren handelsüblichen Formulierungen sowie in den aus diesen Formulierungen bereiteten Anwendungsformen in Mischungen mit ein oder mehreren Wirkstoffen aus der Gruppe bestehend aus Insektiziden, Lockstoffen,Moreover, in their commercial formulations and in the forms of use prepared from these formulations in mixtures with one or more active substances selected from the group consisting of insecticides, attractants,
Sterilantien, Akariziden, Nematiziden, Fungiziden, wachstumsregulierenden Stoffen, die Pflanzenreife beeinflussenden Stoffe, oder Safenern vorliegen. Sterilants, acaricides, nematicides, fungicides, growth regulators, the plant maturity affecting substances, or safeners are present.
Biologische Beispiele: Biological examples:
Samen von mono- bzw. dikotylen Kulturpflanzen werden in Plastik- oder Seeds of monocotyledonous or dicotyledonous crops are in plastic or
Holzfasertöpfen in sandigem Lehmboden ausgesät, mit Erde oder Sand abgedeckt und im Gewächshaus unter guten Wachstumsbedingungen angezogen. Die Behandlung der Versuchspflanzen erfolgt im frühen Laubblattstadium (BBCH10 - BBCH13). Zur Gewährleistung einer uniformen Wasserversorgung vor Stressbeginn werden die bepflanzten Töpfe vor Substanzapplikation durch Anstaubewässerung mit Wasser versorgt. Wood fiber pots seeded in sandy loam soil, covered with soil or sand and grown in the greenhouse under good growth conditions. The Treatment of the test plants takes place in the early leaves leaf stage (BBCH10 - BBCH13). To ensure a uniform supply of water before the onset of stress, the planted pots are supplied with water by means of dewatering prior to substance application.
Die in Form von benetzbaren Pulvern (WP) formulierten erfindungsgemäßen The formulated according to the invention in the form of wettable powders (WP)
Verbindungen werden als wässrige Suspension mit einer Wasseraufwandmenge von umgerechnet 600 l/ha unter Zusatz von 0,2% Netzmittel (z.B. Agrotin) auf die grünen Pflanzenteile gesprüht. Unmittelbar nach Substanzapplikation erfolgt die Compounds are sprayed onto the green parts of plants as an aqueous suspension at a rate of 600 l / ha, with the addition of 0.2% wetting agent (for example, agrotin). Immediately after substance application is the
Stressbehandlung der Pflanzen. Die Holzfasertöpfe werden dazu in Plastikeinsätze transferiert, um anschließendes, zu schnelles Abtrocknen zu verhindern. Stress treatment of the plants. The wood fiber pots are transferred to plastic inserts to prevent subsequent, too fast drying.
Der Trockenstress wird durch langsames Abtrocknen unter folgenden Bedingungen induziert: „Tag": 14 Stunden beleuchtet bei ~ 26-30°C Dry stress is induced by slow drying under the following conditions: "day": 14 hours light at ~ 26-30 ° C
„Nacht": 10 Stunden ohne Beleuchtung bei ~ 18-20°C.  "Night": 10 hours without lighting at ~ 18-20 ° C.
Die Dauer der jeweiligen Stressphasen richtet sich hauptsächlich nach dem Zustand der gestressten Kontrollpflanzen. Sie wird (durch Wiederbewässerung und Transfer in ein Gewächshaus mit guten Wachstumsbedingungen) beendet, sobald irreversible Schäden an den gestressten Kontrollpflanzen zu beobachten sind. The duration of the respective stress phases depends mainly on the condition of the stressed control plants. It is terminated (by irrigation and transfer to a greenhouse with good growth conditions) as soon as irreversible damage to the stressed control plants is observed.
Nach Beendigung der Stressphase folgt eine ca. 4-14 tägige Erholungsphase, während der die Pflanzen abermals unter guten Wachstumsbedingungen im After completion of the stress phase follows a 4-14 day recovery period, during which the plants again under good growing conditions in the
Gewächshaus gehalten werden. Die Dauer der Erholungsphase richtet sich hauptsächlich danach, wann die Versuchspflanzen einen Zustand erreicht haben, der eine visuelle Bonitur potenzieller Effekte ermöglicht, und ist daher variabel. Greenhouse are kept. The duration of the recovery phase depends mainly on when the test plants have reached a state that allows a visual assessment of potential effects, and is therefore variable.
Wenn dieser Zeitpunkt erreicht ist, werden die Schadintensitäten visuell im Vergleich zu unbehandelten, ungestressten Kontrollen gleichen Alters bonitiert. Die Erfassung der Schadintensität erfolgt zunächst in Prozent. Aus diesen Werten wird sodann der Wirkungsgrad der Testverbindungen nach folgender Formel ermittelt: When this time is reached, the damage intensities are scored visually compared to untreated, unstressed controls of the same age. The detection of the damage intensity is initially in percent. From these values, the efficiency of the test compounds is then determined according to the following formula:
WG: Wirkungsgrad (Efficacy) = Reduktion der Schadintensität durch Behandlung mit Testsubstanz WG: Efficacy = Reduction of the damage intensity by treatment with test substance
SU: Schadintensität der gestressten Kontrollpflanzen  SU: damage intensity of the stressed control plants
S : Schadintensität der mit Testverbindung behandelten Pflanzen Bei den in unten stehender Tabelle 1 - 4 angegebenen Werten handelt es sich um Mittelwerte aus mindestens einem Versuch mit mindestens zwei Replikaten.  S: Detrimental intensity of test compound treated plants The values given in Table 1 - 4 below are averages of at least one test involving at least two replicates.
Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) Effects of Selected Compounds of General Formula (I)
unter Kältestress (Tablle 1 ): under cold stress (Table 1):
Tabelle 1 Table 1
Wirkungen ausgewählter Verbindungen der allgemeinen Formel (I) unter Effects of selected compounds of general formula (I) under
Trockenstress (Tabellen 2 bis 4): Drought stress (Tables 2 to 4):
Tabelle 2 Table 2
No. Bsp. Dosierung Einheit WG (ZEAMX) No. Ex. Unit dosage WG (ZEAMX)
1 1212 25 g/ha > 5 1 1212 25 g / ha> 5
2 2223 250 g/ha > 5  2 2223 250 g / ha> 5
3 1578 250 g/ha > 5  3 1578 250 g / ha> 5
4 221 250 g/ha > 5  4 221 250 g / ha> 5
5 777 25 g/ha > 5  5 777 25 g / ha> 5
6 222 250 g/ha > 5 No. Bsp. Dosierung Einheit WG (ZEAMX)6 222 250 g / ha> 5 No. Ex. Unit dosage WG (ZEAMX)
7 223 25 g/ha > 57 223 25 g / ha> 5
8 664 25 g/ha > 58 664 25 g / ha> 5
9 696 25 g/ha > 59,696 25 g / ha> 5
10 2085 250 g/ha > 510 2085 250 g / ha> 5
1 1 2128 25 g/ha > 51 1 2128 25 g / ha> 5
12 170 250 g/ha > 512 170 250 g / ha> 5
13 3 250 g/ha > 513 3 250 g / ha> 5
14 36 250 g/ha > 514 36 250 g / ha> 5
15 219 250 g/ha > 515 219 250 g / ha> 5
16 46 25 g/ha > 516 46 25 g / ha> 5
17 266 25 g/ha > 517 266 25 g / ha> 5
18 1 159 250 g/ha > 518 1 159 250 g / ha> 5
19 2270 25 g/ha > 519 2270 25 g / ha> 5
20 2817 25 g/ha > 520 2817 25 g / ha> 5
21 3920 25 g/ha > 521 3920 25 g / ha> 5
22 3940 25 g/ha > 522 3940 25 g / ha> 5
23 610 25 g/ha > 523 610 25 g / ha> 5
24 2423 2,5 g/ha > 524 2423 2.5 g / ha> 5
25 59 25 g/ha > 525 59 25 g / ha> 5
26 2290 250 g/ha > 5 26 2290 250 g / ha> 5
Tabelle 3 Table 3
WG  WG
No. Bsp. Dosierung Einheit  No. Ex. Dosage unit
(BRSNS) (BRSNS)
1 1785 50 g/ha > 51 1785 50 g / ha> 5
2 1565 250 g/ha > 52 1565 250 g / ha> 5
3 2225 250 g/ha > 53 2225 250 g / ha> 5
4 1688 250 g/ha > 54 1688 250 g / ha> 5
5 225 25 g/ha > 55 225 25 g / ha> 5
6 233 25 g/ha > 56 233 25 g / ha> 5
7 247 25 g/ha > 5 WG7 247 25 g / ha> 5 WG
No. Bsp. Dosierung Einheit No. Ex. Dosage unit
(BRSNS) (BRSNS)
8 256 25 g/ha > 58 256 25 g / ha> 5
9 258 25 g/ha > 59 258 25 g / ha> 5
10 665 250 g/ha > 510 665 250 g / ha> 5
1 1 2016 25 g/ha > 51 1 2016 25 g / ha> 5
12 2020 25 g/ha > 512 2020 25 g / ha> 5
13 813 25 g/ha > 513,813 25 g / ha> 5
14 2220 25 g/ha > 514 2220 25 g / ha> 5
15 2233 25 g/ha > 515 2233 25 g / ha> 5
16 1 154 250 g/ha > 516 1 154 250 g / ha> 5
17 2246 25 g/ha > 517 2246 25 g / ha> 5
18 29 250 g/ha > 518 29 250 g / ha> 5
19 32 250 g/ha > 519 32 250 g / ha> 5
20 13 250 g/ha > 520 13 250 g / ha> 5
21 2251 250 g/ha > 521 2251 250 g / ha> 5
22 204 25 g/ha > 522 204 25 g / ha> 5
23 1744 25 g/ha > 523 1744 25 g / ha> 5
24 46 250 g/ha > 524 46 250 g / ha> 5
25 266 25 g/ha > 525 266 25 g / ha> 5
26 933 25 g/ha > 5 26 933 25 g / ha> 5
Tabelle 4 Table 4
No. Bsp. Dosierung Einheit WG (TRZAS) No. Eg dosage unit WG (TRZAS)
1 243 250 g/ha > 51 243 250 g / ha> 5
2 272 25 g/ha > 52 272 25 g / ha> 5
3 274 250 g/ha > 53 274 250 g / ha> 5
4 265 250 g/ha > 54 265 250 g / ha> 5
5 266 25 g/ha > 55 266 25 g / ha> 5
6 933 250 g/ha > 56 933 250 g / ha> 5
7 4027 250 g/ha > 5 No. Bsp. Dosierung Einheit WG (TRZAS)7 4027 250 g / ha> 5 No. Eg dosage unit WG (TRZAS)
8 1084 250 g/ha > 58 1084 250 g / ha> 5
9 770 25 g/ha > 59 770 25 g / ha> 5
10 2840 250 g/ha > 510 2840 250 g / ha> 5
1 1 3639 25 g/ha > 51 1 3639 25 g / ha> 5
12 3920 25 g/ha > 512 3920 25 g / ha> 5
13 3940 25 g/ha > 513 3940 25 g / ha> 5
14 3699 25 g/ha > 514 3699 25 g / ha> 5
15 3807 25 g/ha > 515 3807 25 g / ha> 5
16 3917 25 g/ha > 516 3917 25 g / ha> 5
17 3170 25 g/ha > 517 3170 25 g / ha> 5
18 3149 25 g/ha > 518 3149 25 g / ha> 5
19 2581 250 g/ha > 5 19 2581 250 g / ha> 5
In den zuvor genannten Tabellen bedeuten: In the aforementioned tables mean:
Bsp. = Verbindung entsprechend dem Bsp. aus Tabelle 1 Example = compound corresponding to the Ex. From Table 1
BRSNS = Brassica napus BRSNS = Brassica napus
TRZAS = Triticum aestivum  TRZAS = Triticum aestivum
ZEAMX = Zea mays  ZEAMX = Zea mays
Ahnliche Ergebnisse konnten auch noch mit weiteren Verbindungen der allgemei Formel (I) auch bei Applikation auf andere Pflanzenarten erzielt werden. Similar results could also be achieved with other compounds of the general formula (I) even when applied to other plant species.

Claims

Patentansprüche BCS13-1009 Claims BCS13-1009
Verwendung substituierter Pyridoncarboxamide der allgemeinen Formel deren Salze Use of substituted Pyridoncarboxamide the general formula whose salts
zur Toleranzerhöhung gegenüber abiotischem Stress in Pflanzen, wobei to increase tolerance to abiotic stress in plants, wherein
R1 (Ci-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (Ci-C6)-Haloalkyl, (C2-C6)- Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl- (Ci-C6)-alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy, (Ci- C6)-Haloalkoxy, (C2-C6)-Haloalkenyloxy, (C2-C6)-Haloalkinyloxy, Cyano, Halogen oder gegebenenfalls ein oder mehrfach substituiertes Phenyl bedeutet, R 1 is (Ci-C 6) -alkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) -alkynyl, (Ci-C 6) -haloalkyl, (C 2 -C 6) - haloalkenyl, (C 2 -C 6 ) -haloalkynyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -cycloalkyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxy, (C 2 -C 6 ) Alkenyloxy, (C 2 -C 6 ) -alkynyloxy, (C 1 -C 6 ) -haloalkoxy, (C 2 -C 6 ) -haloalkenyloxy, (C 2 -C 6 ) -haloalkynyloxy, cyano, halogen or optionally mono- or polysubstituted phenyl,
R2 (Ci-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (Ci-C6)-Haloalkyl, (C2-C6)- Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl- (Ci-C6)-alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy, (Ci- C6)-Haloalkoxy, (C2-C6)-Haloalkenyloxy, (C2-C6)-Haloalkinyloxy, Cyano, Halogen oder gegebenenfalls ein oder mehrfach substituiertes Phenyl bedeutet, R 2 is (Ci-C 6) -alkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) -alkynyl, (Ci-C 6) -haloalkyl, (C 2 -C 6) - haloalkenyl, (C 2 -C 6 ) -haloalkynyl, (C 3 -C 6 ) -cycloalkyl, (C 3 -C 6 ) -cycloalkyl- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkoxy, (C 2 -C 6 ) Alkenyloxy, (C 2 -C 6 ) -alkynyloxy, (C 1 -C 6 ) -haloalkoxy, (C 2 -C 6 ) -haloalkenyloxy, (C 2 -C 6 ) -haloalkynyloxy, cyano, halogen or optionally mono- or polysubstituted phenyl,
R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C4)- Alkylthio, (Ci-C4)-Alkylamino, Di[(Ci-C4)-alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)- Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, R 3 and R 4 independently of one another are hydrogen, (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or halogen by one or more radicals , hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (Ci-C4) - alkylthio, (Ci-C 4) alkylamino, di [(Ci-C 4) - alkyl] -amino, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl which is unsubstituted or substituted, phenyl which unsubstituted or substituted, heteroaryl which is unsubstituted or substituted is substituted or substituted heterocyclyl which is unsubstituted or substituted,
oder  or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) cycloalkyl which is saturated at a side of the ring with a 4 to 6-membered or
ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)- Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-unsaturated carbocyclic ring, or (C 4 -C 6) cycloalkenyl fused on one side of the ring with a 4- to 6-membered saturated or unsaturated carbocyclic ring, each of the last-mentioned 4 unsubstituted or by one or more radicals from the group halogen, hydroxy, cyano, (Ci-C 4 ) -
Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )- Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oderAlkyl, (Ci-C) -haloalkyl, (Ci-C) -alkoxy, (Ci-C) -haloalkoxy, (Ci-C) -alkylthio, (Ci-C) -alkylamino, Di [(Ci-C) - alkyl] amino, [(C 1 -C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted is heteroaryl which is unsubstituted or substituted or
Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, Heterocyclyl which is unsubstituted or substituted is substituted,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder R3 Wasserstoff oder (Ci-C6)-Alkyl bedeutet und Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or R 3 is hydrogen or (C 1 -C 6 ) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-C6)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)-Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 4 is (Ci-C 6) -alkyl, (Ci-C 6) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) -haloalkoxy or ( Ci-C 6 ) -alkyl-SO2, or R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere  form eight-membered heterocyclic ring, in addition to the N-atom and other hetero ring atoms, preferably up to two more
Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio substituiert ist, oder Hetero ring atoms from the group N, O and S may contain and unsubstituted or by one or more radicals from the group halogen, cyano, nitro, (Ci-C) alkyl, (Ci-C) haloalkyl, (Ci-C) Alkoxy, (C 1 -C 4 ) -haloalkoxy, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten, wobei -N = CR 5 -NR 6 R 7 , where
R5 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 5 is hydrogen or (C 1 -C 6) -alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-Ce)-Alkyl bedeuten, oder R6, R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bis siebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl. R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6 ) -alkyl, or R 6 , R 7 together with the directly bonded nitrogen atom form a five to seven-membered, preferably saturated heterocyclic ring, such as piperidinyl, pyrrolidinyl or morpholinyl.
2. Verwendung gemäß Anspruch 1 , wobei in Formel (I) 2. Use according to claim 1, wherein in formula (I)
R1 (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (Ci-Ce)-Alkoxy oder (Ci-C6)-Haloalkoxy bedeutet, R 1 is (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -haloalkyl, (C 3 -C 6 ) -cycloalkyl, (C 1 -C 6 ) -alkoxy or (C 1 -C 6 ) -haloalkoxy,
R2 (Ci-C6)-Alkyl, (Ci-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (Ci-C6)-Alkoxy, (Ci- C6)-Haloalkoxy oder Halogen bedeutet und R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste R 2 is (Ci-C 6) -alkyl, (Ci-C 6) -haloalkyl, (C 3 -C 6) cycloalkyl, (Ci-C 6) alkoxy, (Ci- C6) haloalkoxy or halogen and R 3 and R 4 independently of one another are hydrogen, (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-named 3 radicals
unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C4)- Alkylthio, (Ci-C4)-Alkylamino, Di[(Ci-C4)-alkyl]-amino, Hydroxycarbonyl,unsubstituted or substituted by one or more radicals from the group halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (Ci-C4) - alkylthio, (Ci-C 4) - Alkylamino, di [(C 1 -C 4 ) alkyl] amino, hydroxycarbonyl,
[(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)- Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) -cycloalkyl which is unsubstituted or substituted, phenyl,
unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten,  is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted,
oder  or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) cycloalkyl which is saturated at a side of the ring with a 4 to 6-membered or
ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)- Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (C1-C4)- Alkyl, (Ci-C4)-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, (C1-C4)- Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, unsaturated carbocyclic ring, or (C 4 -C 6) cycloalkenyl fused on one side of the ring with a 4- to 6-membered saturated or unsaturated carbocyclic ring, each of the last-mentioned 4 unsubstituted or by one or more radicals from the group halogen, hydroxy, cyano, (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -haloalkyl, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4) -alkylamino, di [(C 1 -C 4) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) ) Cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder  Phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, or
Wasserstoff oder (Ci-Ce)-Alkyl bedeutet R4 (Ci-C6)-Alkyl, (Ci-C6)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)-Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder Is hydrogen or (C 1 -C 6) -alkyl R 4 is (Ci-C 6) -alkyl, (Ci-C 6) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) -haloalkoxy or ( Ci-C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere  form eight-membered heterocyclic ring, in addition to the N-atom and other hetero ring atoms, preferably up to two more
Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio substituiert ist oder Hetero ring atoms from the group N, O and S may contain and unsubstituted or by one or more radicals from the group halogen, cyano, nitro, (Ci-C) alkyl, (Ci-C) haloalkyl, (Ci-C) Alkoxy, (C 1 -C 4 ) -haloalkoxy, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten und wobei -N = CR 5 -NR 6 R 7 and wherein
R5 für Wasserstoff oder (Ci-Ce)-Alkylsteht und R 5 is hydrogen or (C 1 -C 6) -alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-Ce)-Alkyl bedeuten, oder R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6) -alkyl, or
R6 und R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bissiebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl . Verwendung gemäß Anspruch 1 , wobei in Formel (I) R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R2 (Ci-C6)-Alkyl oder Halogen bedeutet, R 6 and R 7 together with the directly bonded N atom form a five-bissiebengliedrigen, preferably saturated heterocyclic ring, such as piperidinyl, pyrrolidinyl or morpholinyl. Use according to claim 1, wherein in formula (I) R 1 is (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl, R 2 is (C 1 -C 6 ) -alkyl or halogen,
R3 und R4 unabhängig voneinander Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste R 3 and R 4 independently of one another are hydrogen, (C 1 -C 16) -alkyl, (C 2 -C 16) -alkenyl or (C 2 -C 16) -alkynyl, where each of the last-named 3 radicals
unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, (Ci-C4)- Alkylthio, (Ci-C4)-Alkylamino, Di[(Ci-C4)-alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)- Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituted or substituted by one or more radicals from the group halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C 4) haloalkoxy, (Ci-C4) - alkylthio, (Ci-C 4) - alkylamino, di [(Ci-C 4) -alkyl] amino, hydroxycarbonyl, [(Ci-C 4) -alkoxy] carbonyl, [(Ci-C4) -haloalkoxy] carbonyl, (C3-C6) - Cycloalkyl which is unsubstituted or substituted, phenyl which
unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten,  is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or substituted heterocyclyl which is unsubstituted or substituted,
oder  or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) cycloalkyl which is saturated at a side of the ring with a 4 to 6-membered or
ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)- Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, wobei jeder der letztgenannten 4 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)- Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )- Alkylthio, (Ci-C )-Alkylamino, Di[(Ci-C )-alkyl]-amino, [(Ci-C )-Alkoxy]- carbonyl, [(Ci-C4)-Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, das unsubstituiert oder substituiert ist, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeuten, unsaturated carbocyclic ring, or (C 4 -C 6) cycloalkenyl fused on one side of the ring with a 4- to 6-membered saturated or unsaturated carbocyclic ring, each of the last-mentioned 4 unsubstituted or by one or more radicals from the group halogen, hydroxy, cyano, (C 1 -C 4 ) -alkyl, (C 1 -C 4 ) -haloalkyl, (C 1 -C 4 ) -alkoxy, (C 1 -C 4) -haloalkoxy, (C 1 -C 4) -alkylthio, (C 1 -C 4) -alkylamino, di [(C 1 -C 4) -alkyl] -amino, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -haloalkoxy] -carbonyl, (C 3 -C 6) ) Cycloalkyl which is unsubstituted or substituted, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted,
oder Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das or Phenyl which is unsubstituted or substituted, heteroaryl,
unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, bedeuten, oder  is unsubstituted or substituted and is heterocyclyl which is unsubstituted or substituted, or
R3 für Wasserstoff oder (Ci-C6)-Alkyl steht R 3 is hydrogen or (Ci-C 6 ) alkyl
und and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)-Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) -haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis R 3 and R 4 together with the directly attached N atom form a four-bis
achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere  form eight-membered heterocyclic ring, in addition to the N-atom and other hetero ring atoms, preferably up to two more
Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C )-Alkyl, (Ci-C )-Haloalkyl, (Ci-C )-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl und (Ci- C4)-Alkylthio substituiert ist, oder Hetero ring atoms from the group N, O and S may contain and unsubstituted or by one or more radicals from the group halogen, cyano, nitro, (Ci-C) alkyl, (Ci-C) haloalkyl, (Ci-C) Alkoxy, (C 1 -C 4 ) -haloalkoxy, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten und wobei -N = CR 5 -NR 6 R 7 and wherein
R5 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-C6)-Alkyl bedeuten, oder R6, R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bis siebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl. R 5 is hydrogen or (C 1 -C 6) -alkyl and R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6 ) -alkyl, or R 6 , R 7 together with the directly bonded nitrogen atom form a five- to seven-membered, preferably saturated heterocyclic ring, such as piperidinyl, pyrrolidinyl or morpholinyl.
Behandlung von Pflanzen, umfassend die Applikation einer zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksamen, nicht-toxischen Menge einer oder mehrerer der Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3. Treatment of plants comprising the application of a non-toxic amount of one or more of the compounds of the formula (I) which is effective for increasing the resistance of plants to abiotic stress factors, or in each case their salts according to one of Claims 1 to 3.
Behandlung gemäß Anspruch 4, wobei die abiotischen Stressbedingungen einer oder mehrerer Bedingungen ausgewählt aus der Gruppe bestehend aus Dürre, Kältestress, Hitzestress, Trockenstress, osmotischem Stress, Staunässe, erhöhtem Bodensalzgehalt, erhöhtem Ausgesetztsein an Mineralien, The treatment of claim 4, wherein the abiotic stress conditions include one or more conditions selected from the group consisting of drought, cold stress, heat stress, drought stress, osmotic stress, waterlogging, increased soil salt content, increased exposure to minerals,
Ozonbedingungen, Starklichtbedingungen, beschränkter Verfügbarkeit von Stickstoffnährstoffen und beschränkter Verfügbarkeit von Phosphornährstoffen entsprechen.  Ozone conditions, high light conditions, limited availability of nitrogen nutrients and limited availability of phosphorus nutrients.
Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 in der Sprühapplikation auf Pflanzen und Pflanzenteilen in Kombinationen mit einem oder mehrer Use of one or more compounds of the formula (I), or in each case their salts according to one of Claims 1 to 3, in the spray application to plants and plant parts in combinations with one or more
Wirkstoffen ausgewählt aud der Gruppe der Insektizide, Lockstoffe, Akarizide, Fungizide, Nematizide, wachstumsregulatorische Stoffe, Safener, die  Active ingredients selected from the group of insecticides, attractants, acaricides, fungicides, nematicides, growth regulators, safeners
Pflanzenreife beeinflussende Stoffe und Bakterizide.  Plant-maturing substances and bactericides.
Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 in der Sprühapplikation auf Pflanzen und Pflanzenteilen in Kombinationen mit Düngemitteln. Use of one or more compounds of the formula (I), or in each case their salts according to one of Claims 1 to 3, in the spray application to plants and plant parts in combinations with fertilizers.
Verwendung einer oder mehrerer Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 zur Applikation auf Use of one or more compounds of the formula (I), or in each case their salts according to one of Claims 1 to 3 for application
gentechnisch veränderten Sorten, deren Saatgut, oder auf Anbauflächen auf denen diese Sorten wachsen. 9 Verwendung von Sprühlösungen, die eine oder mehrere Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 enthalten, zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren. genetically modified varieties, their seed, or on arable land on which these varieties grow. Use of spray solutions which comprise one or more compounds of the formula (I), or in each case their salts according to one of Claims 1 to 3, for increasing the resistance of plants to abiotic stress factors.
10. Verfahren zur Erhöhung der Stresstoleranz bei Pflanzen ausgewählt aus der Gruppe der Nutzpflanzen, Zierpflanzen, Rasenarten, oder Bäumen, dadurch gekennzeichnet, dass die Applikation einer ausreichenden, nicht-toxischen Menge einer oder mehrere Verbindungen der Formel (I), oder jeweils deren Salze gemäß einem der Ansprüche 1 bis 3 auf die Fläche, wo die 10. A method for increasing the stress tolerance in plants selected from the group of crops, ornamental plants, lawn species, or trees, characterized in that the application of a sufficient, non-toxic amount of one or more compounds of formula (I), or in each case their salts according to one of claims 1 to 3 on the area where the
entsprechende Wirkung gewünscht wird, umfassend die Anwendung auf die Pflanzen, deren Saatgut oder auf die Fläche auf der die Pflanzen wachsen, erfolgt.  corresponding effect is desired, comprising the application to the plants whose seeds or on the surface on which the plants grow takes place.
1 1 . Verfahren gemäß Anspruch 10, wobei die Widerstandsfähigkeit der so 1 1. A method according to claim 10, wherein the resistance of the
behandelten Pflanzen gegenüber abiotischem Stress gegenüber nicht behandelten Pflanzen unter ansonsten gleichen physiologischen Bedingungen um mindestens 3% erhöht ist.  treated plants is increased by at least 3% against abiotic stress compared to untreated plants under otherwise identical physiological conditions.
12. Substituierte Pyridoncarboxamide der allgemeinen Formel (I) oder deren Salze, 12. Substituted pyridone carboxamides of the general formula (I) or salts thereof,
worin  wherein
R1 (Ci-C6)-Alkyl oder (Ci-C6)-Haloalkyl bedeutet, R 1 is (C 1 -C 6 ) -alkyl or (C 1 -C 6 ) -haloalkyl,
(Ci-C6)-Alkyl oder Halogen bedeutet, R3 Wasserstoff, (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)- Alkoxy, (Ci-C )-Haloalkoxy, (Ci-C )-Alkylthio, (Ci-C )-Alkylamino, Di[(Ci- C4)-alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-(C 1 -C 6) -alkyl or halogen, R 3 is hydrogen, (C 1 -C 6 ) -alkyl, (C 2 -C 6) -alkenyl or (C 2 -C 6) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more radicals from the group consisting of halogen, hydroxy , Cyano, (C 1 -C 4 ) -alkoxy, (C 1 -C 4 ) -haloalkoxy, (C 1 -C 4 ) -alkylthio, (C 1 -C 4 ) -alkylamino, di [(C 1 -C 4 ) -alkyl] -amino, Hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl, [(C 1 -C 4 ) -
Haloalkoxy]-carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeutet, Haloalkoxy] -carbonyl, (C3-C6) -cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted,
oder  or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) cycloalkyl which is saturated at a side of the ring with a 4 to 6-membered or
ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)- Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist bedeutet, is condensed unsaturated carbocyclic ring, or (C 4 -C 6) -cycloalkenyl which is fused on one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das  Phenyl which is unsubstituted or substituted, heteroaryl,
unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet und  is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted, and
R4 (Ci-Ci6)-Alkyl, (C2-Ci6)-Alkenyl oder (C2-Ci6)-Alkinyl, wobei jeder der letztgenannten 3 Reste unsubstituiert oder durch einen oder mehrereR 4 is (C 1 -C 6 ) -alkyl, (C 2 -C 6 ) -alkenyl or (C 2 -C 6) -alkynyl, where each of the last-mentioned 3 radicals is unsubstituted or substituted by one or more
Reste aus der Gruppe Halogen, Hydroxy, Cyano, (Ci-C4)-Alkoxy, (Ci-C4)- Haloalkoxy, (Ci-C4)-Alkylthio, (Ci-C4)-Alkylamino, Di[(Ci-C4)-alkyl]-amino, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]-carbonyl, [(Ci-C4)-Haloalkoxy]- carbonyl, (C3-C6)-Cycloalkyl, Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das unsubstituiert oder substituiert ist und Heterocyclyl, das unsubstituiert oder substituiert ist, substituiert ist bedeutet, Radicals from the group halogen, hydroxy, cyano, (Ci-C 4) alkoxy, (Ci-C4) - haloalkoxy, (Ci-C 4) alkylthio, (Ci-C 4) alkylamino, di [(C C 4 ) alkyl] amino, hydroxycarbonyl, [(C 1 -C 4 ) alkoxy] carbonyl, [(C 1 -C 4 ) haloalkoxy] carbonyl, (C 3 -C 6) cycloalkyl, phenyl which is unsubstituted or substituted, heteroaryl which is unsubstituted or substituted and heterocyclyl which is unsubstituted or substituted, is substituted,
oder  or
(C3-C6)-Cycloalkyl, (C4-C6)Cycloalkenyl, (C3-C6)-Cycloalkyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist, oder (C4-C6)- Cycloalkenyl, das an einer Seite des Rings mit einem 4 bis 6-gliedrigen gesättigten oder ungesättigten carbocyclischen Ring kondensiert ist bedeutet, (C3-C6) -cycloalkyl, (C 4 -C 6) cycloalkenyl, (C3-C6) cycloalkyl which is saturated at a side of the ring with a 4 to 6-membered or is condensed unsaturated carbocyclic ring, or (C 4 -C 6) -cycloalkenyl which is fused on one side of the ring with a 4 to 6-membered saturated or unsaturated carbocyclic ring,
oder  or
Phenyl, das unsubstituiert oder substituiert ist, Heteroaryl, das  Phenyl which is unsubstituted or substituted, heteroaryl,
unsubstituiert oder substituiert ist oder Heterocyclyl, das unsubstituiert oder substituiert ist, bedeutet oder  is unsubstituted or substituted or heterocyclyl which is unsubstituted or substituted, or
R3 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 3 is hydrogen or (C 1 -C 6) -alkyl and
R4 (Ci-C6)-Alkyl, (Ci-Ce)-Alkoxy, (C2-C6)-Alkenyloxy, (C2-C6)-Alkinyloxy oder (C2-C6)-Haloalkoxy oder (Ci-C6)-Alkyl-SO2 bedeutet, oder R 4 is (Ci-C 6) -alkyl, (Ci-Ce) alkoxy, (C2-C6) alkenyloxy, (C 2 -C 6) alkynyloxy or (C 2 -C 6) -haloalkoxy or (C -C 6 ) -alkyl-SO 2 , or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen Aminosäurerest und zwar die natürlich vorkommenden in ihrer racemischen und in ihrer jeweiligen D- und L-Form bedeuten, oder R 3 and R 4 together with the directly bound N atom represent an amino acid residue, namely the naturally occurring in their racemic and in their respective D and L form, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom einen vier - bis achtgliedrigen heterocyclischen Ring bilden, der neben dem N-Atom auch weitere Heteroringatome, vorzugsweise bis zu zwei weitere Heteroringatome aus der Gruppe N, O und S enthalten kann und der unsubstituiert oder durch einen oder mehrere Reste aus der Gruppe Halogen, Cyano, Nitro, (Ci-C4)-Alkyl, (Ci-C4)- Haloalkyl, (Ci-C4)-Alkoxy, (Ci-C4)-Haloalkoxy, Hydroxycarbonyl, [(Ci-C4)-Alkoxy]- carbonyl und (Ci-C4)-Alkylthio bedeuten, oder R 3 and R 4 together with the directly bonded N atom form a four- to eight-membered heterocyclic ring which, in addition to the N atom, may also contain further hetero ring atoms, preferably up to two further hetero ring atoms from the group consisting of N, O and S, and unsubstituted or substituted by one or more radicals from the group halogen, cyano, nitro, (Ci-C 4) alkyl, (Ci-C4) - haloalkyl, (Ci-C 4) alkoxy, (Ci-C 4) - Haloalkoxy, hydroxycarbonyl, [(C 1 -C 4 ) -alkoxy] -carbonyl and (C 1 -C 4 ) -alkylthio, or
R3 und R4 zusammen mit dem direkt gebundenen N-Atom die Gruppe R 3 and R 4 together with the directly attached N atom, the group
-N=CR5-NR6R7 bedeuten, Mean -N = CR 5 -NR 6 R 7 ,
R5 für Wasserstoff oder (Ci-Ce)-Alkyl steht und R 5 is hydrogen or (C 1 -C 6) -alkyl and
R6 und R7 unabhängig voneinander Wasserstoff oder (Ci-Ce)-Alkyl bedeuten, oder R 6 and R 7 independently of one another denote hydrogen or (C 1 -C 6) -alkyl, or
R6 und R7 bilden zusammen mit dem direkt gebundenen N-Atom einen fünf- bis siebengliedrigen, vorzugsweise gesättigten heterocyclischen Ring, wie beispielsweise Piperidinyl, Pyrrolidinyl oder Morpholinyl bedeuten, ausgenommen Verbindungen der allgemeinen Formel (I), in denen R 6 and R 7 together with the directly bonded N atom represent a five to seven membered, preferably saturated heterocyclic ring, such as piperidinyl, pyrrolidinyl or morpholinyl, with the exception of compounds of general formula (I) in which
(a) R1 und R2 für Methyl, R3 für Wasserstoff und R4 für Benzyl steht, oder(a) R 1 and R 2 are methyl, R 3 is hydrogen and R 4 is benzyl, or
(b) wenn R1 für (Ci-C6)-Haloalkyl und R2 gleichzeitig für Halogen steht. (b) when R 1 is (C 1 -C 6) haloalkyl and R 2 is simultaneously halogen.
Sprühlösung zur Behandlung von Pflanzen, enthaltend eine zur Steigerung der Widerstandsfähigkeit von Pflanzen gegenüber abiotischen Stressfaktoren wirksame Menge einer oder mehrerer der substituierten Pyridoncarboxamide gemäß einem der Ansprüche 12. A spray solution for the treatment of plants, comprising an amount of one or more of the substituted pyridone carboxamides effective to increase the resistance of plants to abiotic stresses, according to any one of claims 12.
EP14737209.8A 2013-07-09 2014-07-07 Use of selected pyridone carboxamides or salts thereof as active substances against abiotic plant stress Withdrawn EP3019012A1 (en)

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