EP3017831A1 - Dispositif biomédical, son procédé de fabrication et son utilisation - Google Patents

Dispositif biomédical, son procédé de fabrication et son utilisation Download PDF

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Publication number
EP3017831A1
EP3017831A1 EP15194631.6A EP15194631A EP3017831A1 EP 3017831 A1 EP3017831 A1 EP 3017831A1 EP 15194631 A EP15194631 A EP 15194631A EP 3017831 A1 EP3017831 A1 EP 3017831A1
Authority
EP
European Patent Office
Prior art keywords
area
biomedical device
powder
micrometers
laser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15194631.6A
Other languages
German (de)
English (en)
Inventor
Didier Nimal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP3017831A1 publication Critical patent/EP3017831A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
    • B22F5/10—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B28—WORKING CEMENT, CLAY, OR STONE
    • B28B—SHAPING CLAY OR OTHER CERAMIC COMPOSITIONS; SHAPING SLAG; SHAPING MIXTURES CONTAINING CEMENTITIOUS MATERIAL, e.g. PLASTER
    • B28B1/00—Producing shaped prefabricated articles from the material
    • B28B1/001—Rapid manufacturing of 3D objects by additive depositing, agglomerating or laminating of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/141—Processes of additive manufacturing using only solid materials
    • B29C64/153—Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/25—Solid
    • B29K2105/251—Particles, powder or granules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7532—Artificial members, protheses

Definitions

  • the present invention avoids the drawbacks of the prior art methods, as it is a one-step method for a direct manufacturing of a tridimensional object from a three-dimensional virtual object through laser technology, without using any mould.
  • Another preferred bioglass has the following composition: 53% SiO 2 , 11% K 2 O and 6%Na 2 O 5% MgO 22%CaO and 2%P 2 O 5 and 1% B 2 O 3 in weight, to the total weight of the bioglass.
  • the biomaterial of the invention includes a first peripheric area which may be hydroapatite, and a second core area, which may be TZP.
  • the first area prior to implantation, is impregnated with a cell growth medium suitable for osteoblasts growth and/or is in contact or impregnated with growth factors. It may then seeded or colonized by tissue forming cells.
  • the particles may have a granulometry of 1 to 500 micrometers, preferably 5 to 100 micrometers, more preferably 10 à 25 micrometers.
  • the trajectory of the laser may have a deviation between the laser beams and the deviation may range from 50 to 150 micrometers, preferably from 70 and 110 micrometers.
  • the full biomedical device is made.
  • the non-processed powder is blown out.
  • a laser YAG 160 Watts is preferably used to locally impact and process the powder.
  • the power of the laser beam may preferably be adjusted to 10% of the total power of the laser in order to avoid vitrification of the ceramic powder; the laser beam may be 10% defocused; the laser deviation may be 80 micrometers; the progression speed of the laser beam may be of 4 mm/s.
  • the trajectory of the laser is defined by the 3D-image.
  • a first area preferably located at the periphery of the structure, may be a matrix-type microstructure colonizable by the patient's osteoblasts.
EP15194631.6A 2009-07-23 2010-06-23 Dispositif biomédical, son procédé de fabrication et son utilisation Withdrawn EP3017831A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2009/054225 WO2011010189A1 (fr) 2009-07-23 2009-07-23 Dispositif médical et procédé de fabrication et d’utilisation associé
EP10730749.8A EP2456474B1 (fr) 2009-07-23 2010-06-23 Procédé de fabrication d'un dispositif biomédical

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP10730749.8A Division-Into EP2456474B1 (fr) 2009-07-23 2010-06-23 Procédé de fabrication d'un dispositif biomédical
EP10730749.8A Division EP2456474B1 (fr) 2009-07-23 2010-06-23 Procédé de fabrication d'un dispositif biomédical

Publications (1)

Publication Number Publication Date
EP3017831A1 true EP3017831A1 (fr) 2016-05-11

Family

ID=41786210

Family Applications (3)

Application Number Title Priority Date Filing Date
EP09736297.4A Not-in-force EP2456473B1 (fr) 2009-07-23 2009-07-23 Dispositif médical et procédé de fabrication et d utilisation associé
EP15194631.6A Withdrawn EP3017831A1 (fr) 2009-07-23 2010-06-23 Dispositif biomédical, son procédé de fabrication et son utilisation
EP10730749.8A Not-in-force EP2456474B1 (fr) 2009-07-23 2010-06-23 Procédé de fabrication d'un dispositif biomédical

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP09736297.4A Not-in-force EP2456473B1 (fr) 2009-07-23 2009-07-23 Dispositif médical et procédé de fabrication et d utilisation associé

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10730749.8A Not-in-force EP2456474B1 (fr) 2009-07-23 2010-06-23 Procédé de fabrication d'un dispositif biomédical

Country Status (5)

Country Link
US (2) US8862258B2 (fr)
EP (3) EP2456473B1 (fr)
CA (1) CA2769032C (fr)
ES (1) ES2571045T3 (fr)
WO (2) WO2011010189A1 (fr)

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Also Published As

Publication number Publication date
EP2456474A2 (fr) 2012-05-30
EP2456473A1 (fr) 2012-05-30
CA2769032A1 (fr) 2011-01-27
EP2456474B1 (fr) 2016-02-10
WO2011009688A3 (fr) 2011-03-31
WO2011009688A2 (fr) 2011-01-27
US8862258B2 (en) 2014-10-14
CA2769032C (fr) 2018-01-23
WO2011010189A1 (fr) 2011-01-27
ES2571045T3 (es) 2016-05-23
US20120165954A1 (en) 2012-06-28
EP2456473B1 (fr) 2016-02-17
US20140377321A1 (en) 2014-12-25

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