EP2993133A1 - Assembly and method for repackaging different medication from their respective original blister packs into filling blister packs - Google Patents

Assembly and method for repackaging different medication from their respective original blister packs into filling blister packs Download PDF

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Publication number
EP2993133A1
EP2993133A1 EP14183954.8A EP14183954A EP2993133A1 EP 2993133 A1 EP2993133 A1 EP 2993133A1 EP 14183954 A EP14183954 A EP 14183954A EP 2993133 A1 EP2993133 A1 EP 2993133A1
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EP
European Patent Office
Prior art keywords
blister
original
carrier
medicaments
blisters
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Granted
Application number
EP14183954.8A
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German (de)
French (fr)
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EP2993133B1 (en
Inventor
Edwin Kohl
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Individual
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Individual
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Publication date
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Priority to ES14183954.8T priority Critical patent/ES2626779T3/en
Priority to EP14183954.8A priority patent/EP2993133B1/en
Priority to CA2960322A priority patent/CA2960322A1/en
Priority to PCT/EP2015/070125 priority patent/WO2016037923A1/en
Priority to US15/509,482 priority patent/US20170253353A1/en
Publication of EP2993133A1 publication Critical patent/EP2993133A1/en
Application granted granted Critical
Publication of EP2993133B1 publication Critical patent/EP2993133B1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
    • B65B35/10—Feeding, e.g. conveying, single articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices

Definitions

  • the invention relates to a system and a method for repackaging of different drugs from their respective Originalblisterverpackungs in Be Shellblister, especially patient-individual Kliblister having arranged in matrix configuration receptacles with rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week.
  • the DE 10 2004 034 024 A2 is an individual blister pack for the weekly drug needs of a patient (weekly blister) known to take the medication in a order by date, day of the week and time of day (morning, noon and evening and / or night) ordered.
  • the receiving compartments of the blister pack for receiving the respective medicaments are arranged in matrix form with seven daily columns, each with at least three time-of-day compartments, which are closed overall by a continuous blister foil.
  • Affixed to the blister pack is a carton-shaped lid, on which the patient-individual the composition of the individual time of day subjects as well as prescription information concerning the respective medicaments is contained.
  • Such weekly blister packs are for patients who regularly need to take several different drugs, a help not only to remember the intake of important medications and on the other hand to keep a reliable overview of what medications are already taken to avoid a potentially harmful over-medication ,
  • WO 2005 102 841 A1 is a system for equipping such patient-specific blister packs with the desired drug composition known.
  • a dispensing station For each drug, a dispensing station is provided which conveys the medicaments from a temporary package in the form of a strip blister into the corresponding receiving compartments of the packaging unit by spatulas associated with the receiving compartments of the blister pack. All patient-specific blister packs cyclically pass through all the dispensing stations of the system, whereby only at those stations medications are taken which correspond to the prescription data associated with the individual blister pack. In this way, patient-specific packaging units can be filled automatically and safely with a selection of several hundred drugs.
  • the EP 2 754 615 describes a system and a method for patient-specific placement of Be colllblistern with medication according to prescribed prescription data, wherein the Be collllblister individually one behind the other in a direction of movement along several successively arranged drug filling stations for loading the Behellblister each with a specific drug and each Be sapllblister is controlled individually so that it only the respective required according to the prescription data required drug filling stations for a filling and the other drug filling stations happens.
  • the object is achieved by a method for repackaging a variety of different drugs from their respective Originalblistem in Be Shellblister comprising the process steps: assignment of the filled with drug blisters to a blister carrier provided for the respective original blister carrier with standardized outer dimensions, packaging the filled with drugs Originalblister in the assigned Blister support, intermediate storage of the blister packs in a blotter, in an interim storage, upon request, removal of the original blister of a selected one of the plurality of drugs from the blotter, and ejection of a defined number of units of the selected drug from the blister to the blister.
  • the object is further achieved by the system for repackaging a plurality of different drugs from their respective original blisters in Be Shellblister, comprising a conveyor for separating and feeding of filled original blisters, a temporary storage with random access to the intermediate storage of the original blister packaged in for a respective original blister type associated blister carrier standardized outer dimensions, and an ejector for ejecting a defined number of units of a selected drug from the respective original blister in the Be colllblister.
  • the invention further proposes a blister carrier for receiving a master blister with medicaments packaged therein, comprising a carrier member having a number of apertures for receiving the blister chambers of the master blister, a lid member having the same number of apertures as ejection apertures for the blister in the original blister packaged medicines, and identification means for identifying the blister carrier.
  • the invention thus allows the operation of a single drug filling station, which is able to fill Be Pavllblister patient-individually controlled with several different drugs.
  • the intermediate storage of the medication in their original blister packs allows a maximum storage time.
  • the blister carriers with standardized outer dimensions assigned to the respective types of medication enable efficient storage, handling and safe deflaking of the original blister packs.
  • the blister carriers each comprise a support member having a number of apertures for receiving the blister chambers of the master blister, a lid member having the same number of apertures as ejection apertures for the medicaments packaged in the master blister.
  • the blister carriers preferably have different opening patterns for receiving different original blisters.
  • the blister carriers may further comprise an identification device such as an RFID chip or a bar code or QR code for identifying the respective blister carrier and thus the type of drug stored therein.
  • an identification device such as an RFID chip or a bar code or QR code for identifying the respective blister carrier and thus the type of drug stored therein.
  • the intermediate storage for storing the blister packs packaged in the original blister packs may for example be designed as a drawer storage that allows space-efficient storage and selective access to the blister carrier.
  • a deblistering device with a plurality of different medicament ejection tappets may preferably be provided which are each adapted to a specific medicament and / or original blister form and / or the openings of the blister carrier.
  • the different drug ejection rams are preferably rotatably mounted on an axis for random access.
  • the Entblistanss Paind arthritis may have a perforation device for perforation of the blister foil in the blister zones of the ejected drugs of the original blister.
  • the original blister remains in the blister carrier during the drug ejection process, the blister being placed in an orientation with blistering stations facing down on the blister carrier, and the drugs ejected from the blisters in reverse orientation with blistering upwardly facing blisters.
  • the drugs are ejected from the original blister in a pre-metering magazine and transported from there in a temporally decoupled second step in the Be Stirllblister.
  • the time-critical process of filling the Be Glallblisters is decoupled from the mechanically difficult process of expelling the drugs from the original blister.
  • optical sensor means are provided for checking the proper discharge of the selected drugs from the original blister into the pre-metering magazine and / or the correct placement of the inflation blisters.
  • Partially filled original blisters are preferably stored together with blister carrier in the intermediate storage and completely emptied blisters are disposed of accordingly.
  • the apparatus and method of the invention serve to repackage a larger number (e.g., 100) of various medicaments, typically supplied in a variety of molded original blister packs.
  • the individual medicines are delivered in their original packaging and the blister packs are manually or mechanically removed and separated from the respective outer packagings (not shown).
  • the individualized original blister packs 10 are then assigned to suitable blister carriers 20, which correspond to the packaging and storage of the different medicaments in their respective original blister packs 10 in the intermediate storage 50 according to the invention.
  • Figures 1A and 1B serve.
  • blister carriers 20 are provided for all desired types of medication, wherein different drugs with similarly shaped original blister packs 10 can be assigned to identical blister carriers 20. It is important that the outer dimensions of all blister carrier 20 standardized, preferably identical.
  • a blister carrier 20 consists of a carrier part 21 and a lid part 22 hinged by means of a hinge connection 24 or the like.
  • Carrier part 21 and cover part 22 both have a hole pattern 23 coordinated with the respective original blister pack 10.
  • the original blister pack 10 with the film side up on the hole pattern 23 of the support member 21 of the blister carrier 20, as shown in FIG FIG. 2 is illustrated.
  • the hole pattern 23 takes on the Blisterhöfe 12 of the original blister 10.
  • the lid member 22 is closed, as in FIG. 3 is illustrated.
  • the outer dimensions of the blister carrier 20 are preferably all identical, so that they can be stored and transported efficiently in the intermediate storage 50.
  • Each blister carrier 20 also has an identification device 27, such as an RFID chip 27 (FIG. FIG. 4 ) for identifying the drug stored in the blister carrier 20.
  • FIG. 1B shows the drawer storage 50 with an extended drawer 52.
  • the drawer storage 50 allows optional access to each of the stored therein blister carrier 20 with it in the respective original blister 10 packaged drugs.
  • the control technique determines the position of the desired medicament packaged in one of the blister carriers 20, which is removed from the drawer bearing 50 by means of the actuator 54 and conveyed on the conveyor line 66 by a carriage 68 the Entblist mecanics owned 80 is fed, which schematically in FIG. 4 is shown.
  • the blister carrier 20 arrives at the deflagration position where the medicaments 15 are successively ejected into the compartments 74 of a pre-metering magazine 70 by means of a suitable ejection ram 82. As in FIG.
  • the shape of the ejection ram 82 is optimized for the smooth ejection of the medicaments 15 from the respective original blister packs 10 and in particular adapted to the shape of the openings 23 of the blister carrier 20 used, the shape of the medicaments 15 and / or the shape of the blister stations 12 of the original blister 10.
  • the deblistering device 70 preferably has a perforation device 95 which is schematically illustrated in FIG FIG. 5 is shown and the film of the original blister 10 perforated at the positions of Blisterhöfe. Such a perforation is schematically designated by the reference numeral 11.
  • the pre-metering magazine 70 of the illustrated embodiment of the invention has seven pre-metering compartments 72 corresponding to the seven weekday columns of the filling blister 40, whereby according to the invention a different number of compartments 72 is also possible.
  • Slits are preferably provided in the lower region of the side walls of the predosing compartments 72 for optically checking whether or not there is a medicament in the respective predosing compartment 72.
  • the medicaments are dispensed from the pre-metering compartments 72 of the pre-metering magazine 70 into the corresponding compartments 42 of the patient-individual filling blister 40, as in FIG FIG. 6 is shown schematically.
  • the pre-metering magazine 70 is positioned above the respective (time of day) line of the filling blister 40 and the medicaments 15 are thrown off into the respective receiving compartments 42 of the filling blister 40 by pushing back the bottom part 74 of the predosing compartments 72.
  • the Be colllblister 40 has arranged in matrix configuration receptacles 42 which are arranged in the illustrated embodiment in four lines corresponding to a number of intake times during a day (morning, noon, evening, night) and seven columns corresponding to the days of a week.
  • the invention is not limited to this particular arrangement of the receiving compartments 42 of the Be colllblisters.
  • Sensor devices 90, 92 such as light barriers, are furthermore preferably provided, which check the transfer of the medicaments from the original blister pack 10 into the predosing magazine 70 and further into the temporary compartments 42 of the filling blister 40 and generate an error message in the event of an error.
  • An embodiment of the method according to the invention for personal placement of Be Pavllblistern is schematically in the flowchart of FIG. 7 fauxgefsst.
  • a first method step S1 the medicaments present in the original blister are assigned to a specific blister carrier, packaged in this blister carrier in method step S3, and temporarily stored in the intermediate storage in the subsequent method step S5.
  • step S7 a selected one of the intermediately stored medicaments is then removed from the intermediate storage facility and fed to the deflaking device, where it is ejected in process step S8 into the pre-metering magazine.
  • the selected medicaments are dispensed from the pre-metering magazine into the corresponding compartments of the filling blister. It should be noted that the use of the pre-metering magazine is advantageous, but the invention is not limited thereto.
  • the invention thus makes it possible, at a single medication filling station, to fill inflation blisters in a patient-controlled manner with a plurality of different medicaments.
  • the storage of the medication in the intermediate storage in the original blisters allows a maximum storage time.
  • the storage of the (partially) filled original blisters takes place with the help of assigned blister carriers with standardized outer dimensions, which allow an efficient storage, handling and blistering of the original blisters.
  • the optional use of the pre-metering magazine 70 in the placement system according to the invention ensures that the ejection process from the original blister 10 and the loading process of the filling blister 40 are decoupled from one another.
  • the time-critical filling process of the filling blister 40 with respect to speed can be optimized for the performance of the overall system, while more time is available for the mechanically difficult ejection process from the original blister 10 without impairing the performance of the overall system.

Abstract

Die Erfindung betrifft eine Anlage und ein Verfahren zur Umverpackung von unterschiedlichen Medikamenten aus deren jeweiligen Originalblisterverpackungen in Befüllblister, insbesondere patientenindividuelle Wochenblister aufweisend in Matrixkonfiguration angeordnete Aufnahmefächer mit Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages und Spalten entsprechend einer Anzahl von Tagen, beispielsweise Wochentagen. Die erfindungsgemäße Anlage weist eine Fördereinrichtung zur Vereinzelung und Zuführung von gefüllten Originalblistern, ein Zwischenlager mit wahlfreiem Zugriff zur Zwischenlagerung der Originalblister verpackt in für einen jeweiligen Originalblistertyp zugeordneten Blisterträgern mit standardisierten Außenabmessungen, und eine Ausstoßeinrichtung zum Ausstoß einer definierten Anzahl von Einheiten eines ausgewählten Medikaments aus dem jeweiligen Originalblister in den Befüllblister auf.The invention relates to a system and a method for repackaging of different drugs from their respective Originalblisterverpackungs in Befüllblister, especially patient-individual Wochenblister having arranged in matrix configuration receptacles with rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week. The apparatus according to the invention comprises a conveyor for singulating and feeding filled original blisters, a temporary storage for intermediate storage of the original blister packaged in blister carriers of standardized outer dimensions associated with each original blister type, and ejector means for ejecting a defined number of units of a selected medicament from the each original blister in the Befüllblister on.

Description

Gebiet der ErfindungField of the invention

Die Erfindung betrifft eine Anlage und ein Verfahren zur Umverpackung von unterschiedlichen Medikamenten aus deren jeweiligen Originalblisterverpackungen in Befüllblister, insbesondere patientenindividuelle Wochenblister aufweisend in Matrixkonfiguration angeordnete Aufnahmefächer mit Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages und Spalten entsprechend einer Anzahl von Tagen, beispielsweise Wochentagen.The invention relates to a system and a method for repackaging of different drugs from their respective Originalblisterverpackungs in Befüllblister, especially patient-individual Wochenblister having arranged in matrix configuration receptacles with rows corresponding to a number of times during a day and columns corresponding to a number of days, such as days of the week.

Verwandter Stand der TechnikRelated prior art

Aus der DE 10 2004 034 024 A2 ist eine individuelle Blisterpackung für den wöchentlichen Medikamentenbedarf eines Patienten (Wochenblister) bekannt, der die Medikamente in einer nach Datum, Wochentag und Tageszeit (Morgen, Mittag und Abend und/oder Nacht) geordneten Folge einnehmen soll. Die Aufnahmefächer der Blisterpackung zur Aufnahme der jeweiligen Medikamente sind in Matrixform angeordnet mit sieben Tagesspalten mit jeweils mindestens drei Tageszeit-Fächern, die insgesamt durch eine zusammenhängende Blisterfolie verschlossen sind. An der Blisterpackung angebracht ist ein kartonförmiger Deckel, auf dem patientenindividuell die Zusammensetzung der einzelnen Tageszeit-Fächer sowie Verschreibungs-Informationen betreffend die jeweiligen Medikamente enthalten ist.From the DE 10 2004 034 024 A2 is an individual blister pack for the weekly drug needs of a patient (weekly blister) known to take the medication in a order by date, day of the week and time of day (morning, noon and evening and / or night) ordered. The receiving compartments of the blister pack for receiving the respective medicaments are arranged in matrix form with seven daily columns, each with at least three time-of-day compartments, which are closed overall by a continuous blister foil. Affixed to the blister pack is a carton-shaped lid, on which the patient-individual the composition of the individual time of day subjects as well as prescription information concerning the respective medicaments is contained.

Derartige Wochenblister sind für Patienten, die regelmäßig mehrere verschiedene Medikamente einnehmen müssen, eine Hilfe dafür, einerseits das Einnehmen wichtiger Medikamente nicht zu vergessen und andererseits auch einen zuverlässigen Überblick darüber zu behalten, welche Medikamente schon eingenommen sind, um eine unter Umständen schädliche Übermedikation zu vermeiden.Such weekly blister packs are for patients who regularly need to take several different drugs, a help not only to remember the intake of important medications and on the other hand to keep a reliable overview of what medications are already taken to avoid a potentially harmful over-medication ,

Aus der WO 2005 102 841 A1 ist eine Anlage zur Bestückung von derartigen patientenindividuellen Blisterpackungen mit der gewünschten Medikamentenzusammenstellung bekannt. Für jedes Medikament ist eine Ausgabestation vorgesehen, die mittels den Aufnahmefächern der Blisterpackung räumlich zugeordneten Stösseln die jeweiligen Medikamente aus einer vorübergehenden Verpackung in Form eines Streifenblisters in die entsprechenden Aufnahmefächer der Verpackungseinheit befördert. Alle patientenindividuellen Blisterpackungen durchlaufen taktweise alle Ausgabestationen der Anlage, wobei nur an denjenigen Stationen Medikamente aufgenommen werden, die den der individuellen Blisterpackung zugeordneten Verschreibungsdaten entsprechen. So können patientenindividuelle Verpackungseinheiten mit einer Auswahl aus mehreren hundert Medikamenten vollautomatisch sicher und zuverlässig befüllt werden.From the WO 2005 102 841 A1 is a system for equipping such patient-specific blister packs with the desired drug composition known. For each drug, a dispensing station is provided which conveys the medicaments from a temporary package in the form of a strip blister into the corresponding receiving compartments of the packaging unit by spatulas associated with the receiving compartments of the blister pack. All patient-specific blister packs cyclically pass through all the dispensing stations of the system, whereby only at those stations medications are taken which correspond to the prescription data associated with the individual blister pack. In this way, patient-specific packaging units can be filled automatically and safely with a selection of several hundred drugs.

Die EP 2 754 615 beschreibt eine Anlage und ein Verfahren zur patientenindividuellen Bestückung von Befüllblistern mit Medikamenten entsprechend vorgegebenen Verschreibungsdaten, wobei die Befüllblister einzeln hintereinander in einer Bewegungsrichtung entlang von mehreren hintereinander angeordneten Medikamenten-Befüllstationen zur Bestückung der Befüllblister mit jeweils einem bestimmten Medikament geführt und jeder Befüllblister individuell gesteuert wird, so dass dieser nur die entsprechend den Verschreibungsdaten jeweils erforderlichen Medikamenten-Befüllstationen für einen Befüllvorgang anfährt und die anderen Medikamenten-Befüllstationen passiert.The EP 2 754 615 describes a system and a method for patient-specific placement of Befüllblistern with medication according to prescribed prescription data, wherein the Befüllblister individually one behind the other in a direction of movement along several successively arranged drug filling stations for loading the Befüllblister each with a specific drug and each Befüllblister is controlled individually so that it only the respective required according to the prescription data required drug filling stations for a filling and the other drug filling stations happens.

Bei der in der EP 2 754 615 beschriebenen Anlage tritt das Problem auf, dass die Anzahl der verarbeitbaren Medikamente der Anzahl der Befüllstationen entspricht und daher begrenzt ist. Selten verschriebene Medikamente, die ebenfalls eine eigene Befüllstation erfordern, lassen sich mit dieser Befüllanlage daher schwierig zu wirtschaftlichen Konditionen in den Befüllblistern verpacken.When in the EP 2 754 615 described plant occurs the problem that the number of processable drugs corresponds to the number of filling stations and is therefore limited. Rare prescribed medications, which also require their own filling station, can therefore be difficult to package with this filling system at economic conditions in the Befüllblistern.

Zusammenfassung der ErfindungSummary of the invention

Es ist daher eine Aufgabe der Erfindung, die in der EP 2 754 615 beschriebene Anlage so weiterzuentwickeln, dass die Anzahl der verarbeitbaren Medikamente größer ist als die Anzahl der Befüllstationen, d.h. eine Befüllstation vorzuschlagen, die die Befüllung des Befüllblisters mit mehreren unterschiedlichen Medikamenten erlaubt.It is therefore an object of the invention, in the EP 2 754 615 described plant so that the number of processable drugs is greater than the number of filling stations, ie to propose a filling station, which allows the filling of the Befüllblisters with several different drugs.

Gelöst wird die Aufgabe durch ein Verfahren zur Umverpackung einer Vielzahl unterschiedlicher Medikamente aus deren jeweiligen Originalblistem in Befüllblister aufweisend die Verfahrensschritte: Zuordnung der mit Medikamenten gefüllten Originalblister zu einem für den jeweiligen Originalblistertyp vorgesehenen Blisterträger mit standardisierten Außenabmessungen, Verpackung der mit Medikamenten gefüllten Originalblister in dem zugeordneten Blisterträger, Zwischenlagerung der in den Blisterträgern verpackten Originalblister in einem Zwischenlager, auf Anforderung Entnahme des in dem Blisterträger verpackten Originalblisters eines ausgewählten der Vielzahl von Medikamenten aus dem Zwischenlager, und Ausstoß einer definierten Anzahl von Einheiten des ausgewählten Medikaments aus dem Originalblister in den Befüllblister.The object is achieved by a method for repackaging a variety of different drugs from their respective Originalblistem in Befüllblister comprising the process steps: assignment of the filled with drug blisters to a blister carrier provided for the respective original blister carrier with standardized outer dimensions, packaging the filled with drugs Originalblister in the assigned Blister support, intermediate storage of the blister packs in a blotter, in an interim storage, upon request, removal of the original blister of a selected one of the plurality of drugs from the blotter, and ejection of a defined number of units of the selected drug from the blister to the blister.

Die Aufgabe wird ferner gelöst duch Anlage zur Umverpackung einer Vielzahl unterschiedlicher Medikamente aus deren jeweiligen Originalblistern in Befüllblister, aufweisend eine Fördereinrichtung zur Vereinzelung und Zuführung von gefüllten Originalblistern, ein Zwischenlager mit wahlfreiem Zugriff zur Zwischenlagerung der Originalblister, verpackt in für einen jeweiligen Originalblistertyp zugeordneten Blisterträger mit standardisierten Außenabmessungen, und eine Ausstoßeinrichtung zum Ausstoß einer definierten Anzahl von Einheiten eines ausgewählten Medikaments aus dem jeweiligen Originalblister in den Befüllblister.The object is further achieved by the system for repackaging a plurality of different drugs from their respective original blisters in Befüllblister, comprising a conveyor for separating and feeding of filled original blisters, a temporary storage with random access to the intermediate storage of the original blister packaged in for a respective original blister type associated blister carrier standardized outer dimensions, and an ejector for ejecting a defined number of units of a selected drug from the respective original blister in the Befüllblister.

Die Erfindung schlägt weiterhin einen Blisterträger zur Aufnahme eines Originalblisters mit darin verpackten Medikamenten vor, aufweisend ein Trägerteil mit einer Anzahl von Öffnungen zur Aufnahme der Blisterhöfe des Originalblisters, einem Deckelteil mit der gleichen Anzahl von Öffnungen als Ausstoßöffnungen fürdie in dem Originalblister verpackten Medikamente, und einer Identifizierungseinrichtung zur Identifizierung des Blisterträgers.The invention further proposes a blister carrier for receiving a master blister with medicaments packaged therein, comprising a carrier member having a number of apertures for receiving the blister chambers of the master blister, a lid member having the same number of apertures as ejection apertures for the blister in the original blister packaged medicines, and identification means for identifying the blister carrier.

Die Erfindung erlaubt so den Betrieb einer einzigen Medikamenten-Befüllstation, die in der Lage ist, Befüllblister patientenindividuell gesteuert mit mehreren unterschiedlichen Medikamenten zu befüllen. Die Zwischenlagerung der Medikamente in deren Originalblisterverpackungen ermöglicht eine maximale Lagerzeit. Die den jeweiligen Medikamententypen zugeordneten Blisterträger mit standardisierten Außenabmessungen ermöglichen eine effiziente Lagerung, Handhabung und sichere Entblisterung der Originalblisterpackungen.The invention thus allows the operation of a single drug filling station, which is able to fill Befüllblister patient-individually controlled with several different drugs. The intermediate storage of the medication in their original blister packs allows a maximum storage time. The blister carriers with standardized outer dimensions assigned to the respective types of medication enable efficient storage, handling and safe deflaking of the original blister packs.

Vorzugsweise weisen die Blisterträger jeweils ein Trägerteil mit einer Anzahl von Öffnungen zur Aufnahme der Blisterhöfe des Originalblisters, ein Deckelteil mit der gleichen Anzahl von Öffnungen als Ausstoßöffnungen für die in dem Originalblister verpackten Medikamente auf. Zur Lagerung unterschiedlich gestalteter Originalblister weisen die Blisterträger vorzugsweise unterschiedliche Öffnungsmuster zur Aufnahme von unterschiedlichen Originalblistern auf.Preferably, the blister carriers each comprise a support member having a number of apertures for receiving the blister chambers of the master blister, a lid member having the same number of apertures as ejection apertures for the medicaments packaged in the master blister. For storing differently shaped original blisters, the blister carriers preferably have different opening patterns for receiving different original blisters.

Die Blisterträger können ferner eine Identifizierungseinrichtung wie beispielsweise ein RFID-Chip oder einen Barcode oder QR-Code zur Identifizierung des jeweiligen Blisterträgers und damit des darin gelagerten Medikamententyps aufweisen.The blister carriers may further comprise an identification device such as an RFID chip or a bar code or QR code for identifying the respective blister carrier and thus the type of drug stored therein.

Das Zwischenlager zur Lagerung der in den Blisterträgern verpackten Originalblisterpackungen kann beispielsweise als Schubladenlager ausgebildet sein, das eine raumeffiziente Lagerung und wahlweisen Zugriff auf die Blisterträger ermöglicht.The intermediate storage for storing the blister packs packaged in the original blister packs may for example be designed as a drawer storage that allows space-efficient storage and selective access to the blister carrier.

Erfindungsgemäß kann vorzugsweise eine Entblisterungseinrichtung mit einer Mehrzahl von unterschiedlichen Medikamenten-Auswurfstößeln vorgesehen sein, die jeweils an eine bestimmte Medikamenten- und/oder Originalblisterform und/oder die Öffnungen des Blisterträgers angepasst sind. Die unterschiedlichen Medikamenten-Auswurfstößel sind zum wahlfreien Zugriff vorzugsweise auf einer Achse drehbar gelagert.According to the invention, a deblistering device with a plurality of different medicament ejection tappets may preferably be provided which are each adapted to a specific medicament and / or original blister form and / or the openings of the blister carrier. The different drug ejection rams are preferably rotatably mounted on an axis for random access.

Die Entblisterungseinrichtung kann eine Perforationseinrichtung zur Perforation der Blisterfolie im Bereich der Blisterhöfe der auszustoßenden Medikamente des Originalblisters aufweisen.The Entblisterungseinrichtung may have a perforation device for perforation of the blister foil in the blister zones of the ejected drugs of the original blister.

Vorzugsweise verbleibt der Originalblister während des Medikamenten-Ausstoßvorgangs im Blisterträger, wobei der Originalblister in einer Orientierung mit nach unten weisenden Blisterhöfen auf den Blisterträger aufgesetzt und in umgekehrter Orientierung mit nach oben weisenden Blisterhöfen die Medikamente aus den Originalblistern ausgestoßen werden können.Preferably, the original blister remains in the blister carrier during the drug ejection process, the blister being placed in an orientation with blistering stations facing down on the blister carrier, and the drugs ejected from the blisters in reverse orientation with blistering upwardly facing blisters.

Zur Steigerung der Leistungsfähigkeit der Anlage werden die Medikamente aus dem Originalblister in ein Vordosiermagazin ausgestoßen und von dort in einem zeitlich entkoppelten zweiten Arbeitsschritt in den Befüllblister befördert. Dadurch wird der zeitkritische Vorgang der Befüllung des Befüllblisters von dem mechanisch schwierigen Vorgang des Ausstossens der Medikamente aus dem Originalblister entkoppelt.To increase the efficiency of the system, the drugs are ejected from the original blister in a pre-metering magazine and transported from there in a temporally decoupled second step in the Befüllblister. Thus, the time-critical process of filling the Befüllblisters is decoupled from the mechanically difficult process of expelling the drugs from the original blister.

Vorzugsweise sind optische Sensoreinrichtungen zur Überprüfung des ordnungsgemäßen Ausstoßes der ausgewählten Medikamente aus dem Originalblister in das Vordosiermagazin und/oder der korrekten Bestückung der Befüllblister vorgesehen.Preferably, optical sensor means are provided for checking the proper discharge of the selected drugs from the original blister into the pre-metering magazine and / or the correct placement of the inflation blisters.

Teilgefüllte Originalblister werden vorzugsweise mitsamt Blisterträger in das Zwischenlager rückgelagert und vollständig geleerte Originalblister werden entsprechend entsorgt.Partially filled original blisters are preferably stored together with blister carrier in the intermediate storage and completely emptied blisters are disposed of accordingly.

Kurze Beschreibung der ZeichnungenBrief description of the drawings

Die Erfindung wird im Folgenden anhand von Ausführungsbeispielen unter Bezugnahme auf die Zeichnungen im Detail beschrieben.

  • Figur 1A ist eine schematische perspektivische Ansicht des Zwischenlagers eines Ausführungsbeispiels der erfindungsgemäßen Anlage zur Umverpackung von Medikamenten.
  • Figur 1B ist eine Detailansicht des in Fig. 1A gezeigten Zwischenlagers, wobei eine Schublade des Lagers herausgezogen ist.
  • Figur 2 ist eine schematische perspektivische Ansicht dreier Ausführungsbeispiele erfindungsgemäßer Blisterträger in geöffneter Position.
  • Figur 3 ist eine schematische perspektivische Ansicht der drei in Figur 2 gezeigten Ausführungsbeispiele erfindungsgemäßer Blisterträger in geschlossener Position.
  • Figur 4 ist eine schematische perspektivische Ansicht eines Ausführungsbeispiels einer Entblisterungseinrichtung sowie eines Vordosiermagazins der erfindungsgemäßen Anlage zur Umverpackung von Medikamenten.
  • Figur 5 ist eine schematische perspektivische Ansicht eines Ausführungsbeispiels einer der Entblisterungseinrichtung vorgeschalteten Perfomtionseinrichtung der erfindungsgemäßen Anlage zur Umverpackung von Medikamenten.
  • Figur 6 ist eine schematische perspektivische Darstellung des Vorgangs der Übergabe der Medikamente aus dem Vordosiermagazin in den Befüllblister gemäß einem Ausführungsbeispiel des erfindungsgemäßen Verfahrens zur Umverpackung von Medikamenten.
  • Figur 7 ist ein schamatisches Flussdiagramm zur Erläuterung der Verfahrensschritte eines Ausführungsbeispiels des erfindungsgemäßen Verfahrens zur Umverpackung von Medikamenten.
The invention will be described below in detail with reference to exemplary embodiments with reference to the drawings.
  • Figure 1A is a schematic perspective view of the intermediate storage of an embodiment of the inventive system for repackaging of drugs.
  • FIG. 1B is a detailed view of the in Fig. 1A shown intermediate bearing, wherein a drawer of the bearing is pulled out.
  • FIG. 2 is a schematic perspective view of three embodiments of inventive blister carrier in the open position.
  • FIG. 3 is a schematic perspective view of the three in FIG. 2 shown embodiments of inventive blister carrier in the closed position.
  • FIG. 4 is a schematic perspective view of an embodiment of a Entblisterungseinrichtung and a Vordosiermagazins the plant according to the invention for repackaging of drugs.
  • FIG. 5 is a schematic perspective view of an embodiment of the Entblisterungseinrichtung upstream Perfomtionseinrichtung the inventive system for repackaging of drugs.
  • FIG. 6 is a schematic perspective view of the process of transferring the medication from the pre-metering in the Befüllblister according to an embodiment of the inventive method for repackaging of drugs.
  • FIG. 7 is a shamatic flowchart for explaining the method steps of an embodiment of the method according to the invention for repackaging of drugs.

Detaillierte Beschreibung der ErfindungDetailed description of the invention

Im Folgenden wird ein Ausführungsbeispiel der erfindungsgemäßen Anlage und des erfindungsgemäßen Verfahrens zur Umverpackung von Medikamenten aus deren jeweiligen Originalblisterverpackungen in patientenindividuelle Befüllblister anhand der Figuren 1-7 im Detail erläutert.In the following, an embodiment of the system according to the invention and of the method according to the invention for repackaging medicaments from their respective original blister packs into patient-specific filling blisters on the basis of FIG Figures 1-7 explained in detail.

Die erfindungsgemäße Anlage und das erfindungsgemäße Verfahren dienen der Umverpackung einer größeren Anzahl (beispielsweise 100) von verschiedenen Medikamenten, die typischerweise in verschiedenen geformten Originalblisterpackungen geliefert werden. Die einzelnen Medikamente werden in der Originalverpackung angeliefert und die Blisterpackungen aus den jeweiligen (nicht dargestellten) Umverpackungen manuell oder maschinell entnommen und vereinzelt. Die vereinzelten Originalblisterpackungen 10 werden dann geeigneten Blisterträgern 20 zugeordnet, welche der Verpackung und Lagerung der unterschiedlichen Medikamente in deren jeweiligen Originalblisterpackungen 10 in dem erfindungsgemäßen Zwischenlager 50 (Figuren 1A und 1B) dienen. Erfindungsgemäß werden Blisterträger 20 für alle gewünschten Medikamententypen bereitgestellt, wobei unterschiedliche Medikamente mit ähnlich geformten Originalblisterpackungen 10 identischen Blisterträgern 20 zugeordnet werden können. Wichtig ist, dass Außenabmessungen aller Blisterträger 20 standardisiert, vorzugsweise identisch sind.The apparatus and method of the invention serve to repackage a larger number (e.g., 100) of various medicaments, typically supplied in a variety of molded original blister packs. The individual medicines are delivered in their original packaging and the blister packs are manually or mechanically removed and separated from the respective outer packagings (not shown). The individualized original blister packs 10 are then assigned to suitable blister carriers 20, which correspond to the packaging and storage of the different medicaments in their respective original blister packs 10 in the intermediate storage 50 according to the invention. Figures 1A and 1B ) serve. According to the invention, blister carriers 20 are provided for all desired types of medication, wherein different drugs with similarly shaped original blister packs 10 can be assigned to identical blister carriers 20. It is important that the outer dimensions of all blister carrier 20 standardized, preferably identical.

Drei Ausführungsbeispiele erfindungsgemäßer Blisterträger 20 sind schematisch in den Figuren 2 und 3 dargestellt. Ein Blisterträger 20 besteht aus einem Trägerteil 21 und einem mittels einer Schamierverbindung 24 oder dergleichen angelenkten Deckelteil 22. Trägerteil 21 und Deckelteil 22 weisen beide ein auf die jeweilige Originalblisterpackung 10 abgestimmtes Lochmuster 23 auf. Die Originalblisterpackung 10 wird mit der Folienseite nach oben auf das Lochmuster 23 des Trägerteils 21 des Blisterträgers 20 gelegt, wie in Figur 2 illustriert ist. Das Lochmuster 23 nimmt dabei die Blisterhöfe 12 des Originalblisters 10 auf. Dann wird das Deckelteil 22 geschlossen, wie in Figur 3 illustriert ist. Die Außenabmessungen der Blisterträger 20 sind vorzugsweise alle identisch, so dass diese effizient im Zwischenlager 50 gelagert und transportiert werden können. Jeder Blisterträger 20 weist außerdem eine Identifizierungseinrichtungen 27 wie etwa ein RFID-Chip 27 (Figur 4) zur Identifizierung des in dem Blisterträger 20 gelagerten Medikaments auf.Three embodiments of blister carrier 20 according to the invention are shown schematically in FIGS Figures 2 and 3 shown. A blister carrier 20 consists of a carrier part 21 and a lid part 22 hinged by means of a hinge connection 24 or the like. Carrier part 21 and cover part 22 both have a hole pattern 23 coordinated with the respective original blister pack 10. The original blister pack 10 with the film side up on the hole pattern 23 of the support member 21 of the blister carrier 20, as shown in FIG FIG. 2 is illustrated. The hole pattern 23 takes on the Blisterhöfe 12 of the original blister 10. Then, the lid member 22 is closed, as in FIG. 3 is illustrated. The outer dimensions of the blister carrier 20 are preferably all identical, so that they can be stored and transported efficiently in the intermediate storage 50. Each blister carrier 20 also has an identification device 27, such as an RFID chip 27 (FIG. FIG. 4 ) for identifying the drug stored in the blister carrier 20.

Die in den Blisterträgern 20 verpackten Medikamente werden, wie in Figur 1A illusltriert ist, durch an sich bekannte Förderwagen 62 auf einem Förderweg 60 einem ebenfalls an sich bekannten Schubladenlager 50 zugeführt, in welchem die Blisterträger 20 auf effiziente Art und Weise in Schubladen 52 gelagert werden, die durch eine Betätigungseinrichtung 54 ein- und ausfahrbar sind. Figur 1B zeigt das Schubladenlager 50 mit einer ausgefahrenen Schublade 52. Das Schubladenlager 50 ermöglicht wahlweisen Zugriff auf jeden einzelnen der darin gelagerten Blisterträger 20 mit darin im jeweiligen Originalblister 10 verpackten Medikamenten.The medicaments packaged in the blister carriers 20, as in Figure 1A illusltriert is fed by known trolleys 62 on a conveyor 60 to a likewise known per se drawer storage 50, in which the blister carrier 20 are stored in an efficient manner in drawers 52 which are retracted by an actuator 54 and extendable. FIG. 1B shows the drawer storage 50 with an extended drawer 52. The drawer storage 50 allows optional access to each of the stored therein blister carrier 20 with it in the respective original blister 10 packaged drugs.

Wenn ein bestimmtes Medikament zur Befüllung eines Befüllblisters 40 benötigt wird, ermittelt die (nicht dargestellte) Steuertechnik die Position des in einem der Blisterträger 20 verpackten gewünschten Medikaments, welches mithilfe der Betätigungseinrichtung 54 aus dem Schubladenlager 50 entnommen und mittels eines Förderwagens 68 auf der Förderstrecke 66 der Entblisterungseinrichtung 80 zugeführt wird, die schematisch in Figur 4 gezeigt ist. Der Blisterträger 20 gelangt zur Entblisterungsposition, wo die Medikamente 15 mithilfe eines geeigneten Auswurfstößels 82 nacheinander in die Fächer 74 eines Vordosiermagazins 70 ausgeworfen werden. Wie in Figur 4 gezeigt ist, weist die Entblisterungseinrichtung 80 des gezeigten Ausführungsbeispiels eine Mehrzahl von Auswurfstößeln 82 auf, die beispielsweise drehbar um eine Achse angeordnet sind. Die Form der Auswurfstößel 82 ist zum reibungslosen Ausstoß der Medikamente 15 aus den jeweiligen Originalblisterverpackungen 10 optimiert und insbesondere an die Form der Öffnungen 23 der verwendeten Blisterträger 20, der Form der Medikamente 15 und/oder der Form der Blisterhöfe 12 der Originalblister 10 angepasst. Zur Optimierung des Entblisterungsvorgangs weist die Entblisterungseinrichtung 70 außerdem vorzugsweise eine Perforationseinrichtung 95 auf, die schematisch in Figur 5 gezeigt ist und die Folie des Originalblisters 10 an den Positionen der Blisterhöfe perforiert. Eine derartige Perforation ist schematisch mit der Bezugsziffer 11 bezeichnet.When a particular medicament is needed to fill a fill blister 40, the control technique (not shown) determines the position of the desired medicament packaged in one of the blister carriers 20, which is removed from the drawer bearing 50 by means of the actuator 54 and conveyed on the conveyor line 66 by a carriage 68 the Entblisterungseinrichtung 80 is fed, which schematically in FIG. 4 is shown. The blister carrier 20 arrives at the deflagration position where the medicaments 15 are successively ejected into the compartments 74 of a pre-metering magazine 70 by means of a suitable ejection ram 82. As in FIG. 4 is shown, the Entblisterungseinrichtung 80 of the embodiment shown a plurality of ejector rams 82, which are arranged for example rotatably about an axis. The shape of the ejection ram 82 is optimized for the smooth ejection of the medicaments 15 from the respective original blister packs 10 and in particular adapted to the shape of the openings 23 of the blister carrier 20 used, the shape of the medicaments 15 and / or the shape of the blister stations 12 of the original blister 10. to In addition, in order to optimize the deblistering process, the deblistering device 70 preferably has a perforation device 95 which is schematically illustrated in FIG FIG. 5 is shown and the film of the original blister 10 perforated at the positions of Blisterhöfe. Such a perforation is schematically designated by the reference numeral 11.

Das Vordosiermagazin 70 des gezeigten Ausführungsbeispiels der Erfindung weist sieben Vordosierfächer 72 entsprechend den sieben Wochentagsspalten des Befüllblisters 40 auf, wobei erfindungsgemäß auch eine andere Anzahl an Fächern 72 möglich ist. Im unteren Bereich der Seitenwände der Vordosierfächer 72 sind vorzugsweise Schlitze vorgesehen zur optischen Überprüfung, ob sich in dem jeweiligen Vordosierfach 72 ein Medikament befindet oder nicht.The pre-metering magazine 70 of the illustrated embodiment of the invention has seven pre-metering compartments 72 corresponding to the seven weekday columns of the filling blister 40, whereby according to the invention a different number of compartments 72 is also possible. Slits are preferably provided in the lower region of the side walls of the predosing compartments 72 for optically checking whether or not there is a medicament in the respective predosing compartment 72.

Schließlich werden die Medikamente aus den Vordosierfächem 72 des Vordosiermagazins 70 in die entsprechenden Fächer 42 des patientenindividuellen Befüllblisters 40 abgegeben, wie in Figur 6 schematisch dargestellt ist. Dazu wird das Vordosiermagazin 70 über der jeweiligen (Tageszeit-) Zeile des Befüllblisters 40 positioniert und durch Zurückschieben des Bodenteils 74 der Vordosierfächer 72 die Medikamente 15 in die jeweiligen Aufnahmefächer 42 des Befüllblisters 40 abgeworfen. Der Befüllblister 40 weist in Matrixkonfiguration angeordnete Aufnahmefächer 42 auf, welche im gezeigten Ausführungsbeispiel in vier Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages (morgens, mittags, abends, nachts) und sieben Spalten entsprechend den Tagen einer Woche angeordnet sind. Die Erfindung ist jedoch nicht auf diese spezielle Anordnung der Aufnahmefächer 42 des Befüllblisters beschränkt.Finally, the medicaments are dispensed from the pre-metering compartments 72 of the pre-metering magazine 70 into the corresponding compartments 42 of the patient-individual filling blister 40, as in FIG FIG. 6 is shown schematically. For this purpose, the pre-metering magazine 70 is positioned above the respective (time of day) line of the filling blister 40 and the medicaments 15 are thrown off into the respective receiving compartments 42 of the filling blister 40 by pushing back the bottom part 74 of the predosing compartments 72. The Befüllblister 40 has arranged in matrix configuration receptacles 42 which are arranged in the illustrated embodiment in four lines corresponding to a number of intake times during a day (morning, noon, evening, night) and seven columns corresponding to the days of a week. However, the invention is not limited to this particular arrangement of the receiving compartments 42 of the Befüllblisters.

Vorzugsweise sind weiterhin Sensoreinrichtungen 90,92 wie etwa Lichtschranken vorgesehen, die die Übergabe der Medikamente aus der Originalblisterpackung 10 in das Vordosiermagazin 70 und weiter in die jweiligen Fächer 42 des Befüllblisters 40 überprüfen und im Falle eines Fehlers eine Fehlermeldung erzeugen.Sensor devices 90, 92, such as light barriers, are furthermore preferably provided, which check the transfer of the medicaments from the original blister pack 10 into the predosing magazine 70 and further into the temporary compartments 42 of the filling blister 40 and generate an error message in the event of an error.

Ein Ausführungsbeispiel des erfindungsgemäßen Verfahrens zur personenindividuellen Bestückung von Befüllblistern ist schematisch im Flussdiagramm der Figur 7 zusammengefsst. In einem ersten Verfahrensschritt S1 werden die im Originalblisterbefindlichen Medikamente einem bestimmten Blisterträger zugeordnet, in Verfahrensschritt S3 in diesem Blisterträger verpackt und im anschließenden Verfahrensschritt S5 im Zwischenlager zwischengelagert. In Schritt S7 wird dann ein ausgewähltes der zwischengelagerten Medikamente aus dem Zwischenlager entnommen und der Entblisterungseinrichtung zugeführt und dort im Verfahrensschritt S8 in das Vordosiermagazin ausgestoßen. Im letzten Verfahrensschritt S9 werden die ausgewählten Medikamente aus dem Vordosiermagazin in die entsprechenden Fächer des Befüllblisters abgegeben. Es sei angemerkt das die Verwendung des Vordosiermagazins vorteilhaft ist, die Erfindung jedoch nicht darauf beschränkt ist.An embodiment of the method according to the invention for personal placement of Befüllblistern is schematically in the flowchart of FIG. 7 zusammengefsst. In a first method step S1, the medicaments present in the original blister are assigned to a specific blister carrier, packaged in this blister carrier in method step S3, and temporarily stored in the intermediate storage in the subsequent method step S5. In step S7, a selected one of the intermediately stored medicaments is then removed from the intermediate storage facility and fed to the deflaking device, where it is ejected in process step S8 into the pre-metering magazine. In the last method step S9, the selected medicaments are dispensed from the pre-metering magazine into the corresponding compartments of the filling blister. It should be noted that the use of the pre-metering magazine is advantageous, but the invention is not limited thereto.

Die Erfindung ermöglicht so, an einer einzigen Medikamenten-Befüllstation Befüllblister patientenindividuell gesteuert mit mehreren unterschiedlichen Medikamenten zu befüllen. Die Lagerung der Medikamente im Zwischenlager in den Originalblistern erlaubt eine maximale Lagerzeit. Die Lagerung der (teil-) gefüllten Originalblister erfolgt mit Hilfe von zugeordneten Blisterträgern mit standardisierten Außenabmessungen, die eine effiziente Lagerung, Handhabung und Entblisterung der Originalblister ermöglichen.The invention thus makes it possible, at a single medication filling station, to fill inflation blisters in a patient-controlled manner with a plurality of different medicaments. The storage of the medication in the intermediate storage in the original blisters allows a maximum storage time. The storage of the (partially) filled original blisters takes place with the help of assigned blister carriers with standardized outer dimensions, which allow an efficient storage, handling and blistering of the original blisters.

Die optionale Verwendung des Vordosiermagazins 70 bei der erfindungsgemäßen Bestückungsanlage sorgt dafür, dass der Ausstoßvorgang aus dem Originalblister 10 und der Bestückungsvorgang des Befüllblisters 40 voneinander entkoppelt werden. Dadurch kann der für die Leistungsfähigkeit der Gesamtanlage zeitkritische Befüllvorgang des Befüllblisters 40 in Bezug auf Schnelligkeit optimiert werden, während für den mechanisch schwierig auszuführenden Ausstoßvorgang aus dem Originalblister 10 mehr Zeit zur Verfügung steht, ohne die Leistungsfähigkeit der Gesamtanlage zu beeinträchtigen.The optional use of the pre-metering magazine 70 in the placement system according to the invention ensures that the ejection process from the original blister 10 and the loading process of the filling blister 40 are decoupled from one another. As a result, the time-critical filling process of the filling blister 40 with respect to speed can be optimized for the performance of the overall system, while more time is available for the mechanically difficult ejection process from the original blister 10 without impairing the performance of the overall system.

Claims (21)

Verfahren zur Umverpackung einer Vielzahl unterschiedlicher Medikamente aus deren jeweiligen Originaibiistern (10) in Befüllblister (40), welches Verfahren die folgenden Verfahrensschritte aufweist: - Zuordnung der mit Medikamenten gefüllten Originalblister (10) zu einem für den jeweiligen Originalblistertyp vorgesehenen Blisterträger (20) mit standardisierten Außenabmessungen, - Verpackung der mit Medikamenten gefüllten Originalblister (10) in dem zugeordneten Blisterträger (20), - Zwischenlagerung der in den Blisterträgern (20) verpackten Originalblister in einem Zwischenlager (50), - auf Anforderung Entnahme des in dem Blisterträger (20) verpackten Originalblisters (10) eines ausgewählten der Vielzahl von Medikamenten aus dem Zwischenlager (50), und - Ausstoß einer definierten Anzahl von Einheiten des ausgewählten Medikaments aus dem Originalblister in den Befüllblister (40). A method for repackaging a plurality of different medicaments from their respective original containers (10) into filling blisters (40), which method comprises the following method steps: Assignment of the original blister (10) filled with medicaments to a blister carrier (20) with standardized outer dimensions intended for the respective original blister type, Packaging of the drug-filled master blister (10) in the associated blister carrier (20), Intermediate storage of the original blisters packed in the blister carriers (20) in an intermediate store (50), upon request, removing the original blister (10) of a selected one of the plurality of medicaments from the intermediate storage (50) packed in the blister carrier (20), and Ejection of a defined number of units of the selected drug from the original blister into the inflation blister (40). Verfahren nach Anspruch 1, wobei die Blisterträger (20) jeweils ein Trägerteil (21) mit einer Anzahl von Öffnungen (23) zur Aufnahme der Blisterhöfe (12) des Originalblisters (10), ein Deckelteil (22) mit der gleichen Anzahl von Öffnungen (23) als Ausstoßöffnungen für die in dem Originalblister verpackten Medikamente, und eine Identifizierungseinrichtung (27) zur Identifizierung des jeweiligen Blisterträgers (20) aufweisen.Method according to claim 1, wherein the blister carriers (20) each have a carrier part (21) with a number of openings (23) for receiving the blister stations (12) of the original blister (10), a lid part (22) with the same number of openings ( 23) as ejection openings for the medicament packaged in the original blister, and identification means (27) for identifying the respective blister carrier (20). Verfahren nach Anspruch 2, wobei die Blisterträger (20) unterschiedliche Öffnungsmuster (23) zur Aufnahme von unterschiedlichen Originalblistern (10) aufweisen.Method according to claim 2, wherein the blister carriers (20) have different opening patterns (23) for receiving different original blisters (10). Verfahren nach einem der Ansprüche 1 bis 3, wobei während des Medikamenten-Ausstoßvorgangs der Originalblister (10) im Blisterträger (20) verbleibt.The method of any one of claims 1 to 3, wherein during the medicament ejection process, the master blister (10) remains in the blister carrier (20). Verfahren nach Anspruch 4, wobei der Originalblister (10) in einer Orientierung mit nach unten weisenden Blisterhöfen (12) auf den Blisterträger (20) aufgesetzt wird und in umgekehrter Orientierung mit nach oben weisenden Blisterhöfen (12) die Medikamente aus den Originalblistern (10) ausgestoßen werden.Method according to claim 4, wherein the original blister (10) is placed on the blister carrier (20) in an orientation with downwardly facing blister stations (12) and in reverse orientation with upwardly facing blister stations (12) the medication from the original blister (10). be ejected. Verfahren nach einem der Ansprüche 1 bis 5, wobei die Medikamente aus dem Originalblister (10) in ein Vordosiermagazin (70) ausgestoßen und von dort in einem zeitlich entkoppelten zweiten Arbeitsschritt in den Befüllblister (40) befördert werden.Method according to one of claims 1 to 5, wherein the medicaments are ejected from the original blister (10) in a pre-metering magazine (70) and from there in a temporally decoupled second step in the Befüllblister (40) are conveyed. Verfahren nach einem der Ansprüche 1 bis 6, umfassend den Verfahrensschritt der Rücklagerung noch teilgefüllter Originalblister (10) mitsamt Blisterträger (20) in das Zwischenlager (50), während vollständig geleerte Originalblister (10) entsorgt werden.Method according to one of claims 1 to 6, comprising the process step of the return of partially filled Originalblister (10) together with Blisterträger (20) in the intermediate storage (50), while completely emptied Originalblister (10) are disposed of. Verfahren nach einem der Ansprüche 1 bis 7, wobei die Befüllblister (40) mit Medikamenten entsprechend vorgegebenen patientenindividuellen Verschreibungsdaten befüllt werden und die Befüllblister (40) in einer Matrixkonfiguration in Zeilen entsprechend einer Anzahl von Einnahmezeiten während eines Tages und Spalten entsprechend einer Anzahl von Tagen, beispielsweise Wochentagen, angeordnete Aufnahmefächer (42) für jeweilige Medikamenten-Verabreichungseinheiten aufweisen.Method according to one of claims 1 to 7, wherein the Befüllblister (40) are filled with drugs according to predetermined patient-specific prescription data and the Befüllblister (40) in a matrix configuration in rows corresponding to a number of intake times during a day and columns corresponding to a number of days, For example, weekdays, have arranged receiving compartments (42) for respective drug administration units. Anlage zur Umverpackung einer Vielzahl unterschiedlicher Medikamente aus deren jeweiligen Originalblistern (10) in Befüllblister (40), aufweisend eine Fördereinrichtung (60) zur Vereinzelung und Zuführung von gefüllten Originalblistern (10), ein Zwischenlager (50) mit wahlfreiem Zugriff zur Zwischenlagerung der in für einen jeweiligen Originalblistertyp zugeordneten Blisterträgern (20) verpackten Originalblister (10) mit standardisierten Außenabmessungen, und eine Ausstoßeinrichtung (80) zum Ausstoß einer definierten Anzahl von Einheiten eines ausgewählten Medikaments aus dem jeweiligen Originalblister (10) in den Befüllblister (40).Plant for repackaging a plurality of different medicaments from their respective original blisters (10) in Befüllblister (40), comprising a conveyor (60) for singulating and feeding of filled original blisters (10), a temporary storage (50) with random access to the intermediate storage of in original blister packs (20) associated with respective blister types (20) having standardized outer dimensions, and ejector means (80) for ejecting a defined number of units of a selected medicament from the respective blister (10) into the blister (40). Anlage nach Anspruch 9, wobei das Zwischenlager (50) als Schubladenlager ausgebildet ist.Installation according to claim 9, wherein the intermediate storage (50) is designed as a drawer storage. Anlage nach Anspruch 9 oder 10, wobei die Blisterträger (20) jeweils ein Trägerteil (21) mit einer Anzahl von Öffnungen (23) zur Aufnahme der Blisterhöfe des Originalblisters (20), ein Deckelteil (22) mit der gleichen Anzahl von Öffnungen (23) als Ausstoßöffnungen für die in dem Originalblister (10) verpackten Medikamente, und eine Identifizierungseinrichtung (27) zur Identifizierung des jeweiligen Blisterträgers (20) aufweisen.Installation according to claim 9 or 10, wherein the blister carriers (20) each have a carrier part (21) with a number of openings (23) for receiving the blister stations of the original blister (20), a lid part (22) with the same number of openings (23 ) as ejection openings for the medicaments packaged in the original blister (10), and identification means (27) for identifying the respective blister carrier (20). Anlage nach Anspruch 11, wobei die Blisterträger (20) unterschiedliche Öffnungsmuster (23) zur Aufnahme von unterschiedlichen Originalblistern (10) aufweisen.Plant according to claim 11, wherein the blister carriers (20) have different opening patterns (23) for receiving different original blisters (10). Anlage nach Anspruch 12, aufweisend eine Entblisterungseinrichtung (80) mit einer Mehrzahl von unterschiedlichen Medikamenten-Auswurfstößeln (82), die jeweils an eine bestimmte Medikamenten- und/oder Originalblisterform und/oder die Öffnungen (23) des Blisterträgers (20) angepasst sind.An apparatus according to claim 12, comprising a deflagration means (80) having a plurality of different medicament ejection plungers (82) each adapted to a particular medicament and / or original blister form and / or the apertures (23) of the blister carrier (20). Anlage nach Anspruch 13, wobei die Mehrzahl von unterschiedlichen Medikamenten-Auswurfstößeln (82) zum wahlfreien Zugriff auf einer Achse drehbar gelagert ist.The system of claim 13, wherein the plurality of different drug ejection plungers (82) are rotatably mounted for random access on an axis. Anlage nach einem der Ansprüche 10 bis 14, aufweisend eine Perforationseinrichtung (95) zur Perforation der Blisterfolie im Bereich der Blisterhöfe (12) der auszustoßenden Medikamente des Originalblisters (10).Plant according to one of Claims 10 to 14, comprising perforation means (95) for perforating the blister foil in the area of the blister stalls (12) of the medicaments of the original blister (10) to be ejected. Anlage nach einem der Ansprüche 10 bis 15, wobei die Medikamente aus dem Originalblister in ein Vordosiermagazin ausgestoßen und von dort in einem zeitlich entkoppelten zweiten Arbeitsschritt in den Befüllblister (40) befördert werden.Plant according to one of claims 10 to 15, wherein the drugs are ejected from the original blister in a pre-metering magazine and from there in a temporally decoupled second step in the Befüllblister (40) are transported. Anlage nach Anspruch 16, aufweisend optische Sensoreinrichtungen (90, 92) zur Überprüfung des ordnungsgemäßen Ausstoßes der ausgewählten Medikamente aus dem Originalblister (10) in das Vordosiermagazin (70) und/oder der korrekten Bestückung der Befüllblister (40).Plant according to claim 16, comprising optical sensor means (90, 92) for checking the proper discharge of the selected ones Drugs from the original blister (10) into the pre-metering magazine (70) and / or the correct loading of the Befüllblister (40). Blisterträger (20) zur Aufnahme eines Originalblisters (10) mit darin verpackten Medikamenten, aufweisend ein Trägerteil (21) mit einer Anzahl von Öffnungen (23) zur Aufnahme der Blisterhöfe (12) des Originalblisters (10), einem Deckelteil (22) mit der gleichen Anzahl von Öffnungen (23) als Ausstoßöffnungen für die in dem Originalblister verpackten Medikamente, und einer Identifizierungseinrichtung (27) zur Identifizierung des Blisterträgers (20).A blister carrier (20) for receiving a master blister (10) having medicaments packaged therein, comprising a support member (21) having a plurality of apertures (23) for receiving the blister stacks (12) of the master blister (10), a lid member (22) the same number of openings (23) as ejection openings for the drugs packaged in the original blister, and identifying means (27) for identifying the blister carrier (20). Blisterträger (20) nach Anspruch 18, aufweisend unterschiedliche Öffnungsmuster (23) zur Aufnahme von unterschiedlich geformten Originalblistern (10).Blister carrier (20) according to claim 18, comprising different opening patterns (23) for receiving differently shaped original blisters (10). Blisterträger (20) nach Anspruch 19 oder 20, wobei das Deckelteil (22) mit einem Scharnier (24) an dem Trägerteil (21) angebracht ist.The blister carrier (20) according to claim 19 or 20, wherein the lid member (22) is attached to the support member (21) with a hinge (24). Blisterträger (20) nach Anspruch 19, 20 oder 21, wobei die Identifizierungseinrichtung (27) ein RFID-Chip ist.The blister carrier (20) according to claim 19, 20 or 21, wherein the identification means (27) is an RFID chip.
EP14183954.8A 2014-09-08 2014-09-08 Assembly and method for repackaging different medication from their respective original blister packs into filling blister packs Not-in-force EP2993133B1 (en)

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Application Number Priority Date Filing Date Title
ES14183954.8T ES2626779T3 (en) 2014-09-08 2014-09-08 Installation and procedure for repackaging different medicines from their respective original blisters to filling blisters
EP14183954.8A EP2993133B1 (en) 2014-09-08 2014-09-08 Assembly and method for repackaging different medication from their respective original blister packs into filling blister packs
CA2960322A CA2960322A1 (en) 2014-09-08 2015-09-03 Installation and method for repackaging different medicines from their respective original blister packs into organiser blister packs
PCT/EP2015/070125 WO2016037923A1 (en) 2014-09-08 2015-09-03 System and method for repackaging different medications from the respective original blisters thereof into filling blisters
US15/509,482 US20170253353A1 (en) 2014-09-08 2015-09-03 Installation and method for repackaging different medicines from their respective original blister packs into organiser blister packs

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US20170253353A1 (en) 2017-09-07
EP2993133B1 (en) 2017-03-29
ES2626779T3 (en) 2017-07-26
WO2016037923A1 (en) 2016-03-17

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