EP2985015B1 - Spritzenadapter - Google Patents

Spritzenadapter Download PDF

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Publication number
EP2985015B1
EP2985015B1 EP15178923.7A EP15178923A EP2985015B1 EP 2985015 B1 EP2985015 B1 EP 2985015B1 EP 15178923 A EP15178923 A EP 15178923A EP 2985015 B1 EP2985015 B1 EP 2985015B1
Authority
EP
European Patent Office
Prior art keywords
syringe
valve
container
syringe adapter
ventilation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP15178923.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2985015A1 (de
Inventor
Christoph Merhold
Tobias Festel
Sebastian Maag
Gero Eichelkraut
Bernd Spindler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Raumedic AG
Original Assignee
Raumedic AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raumedic AG filed Critical Raumedic AG
Priority to EP17184242.0A priority Critical patent/EP3260108A1/de
Publication of EP2985015A1 publication Critical patent/EP2985015A1/de
Application granted granted Critical
Publication of EP2985015B1 publication Critical patent/EP2985015B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1493—Containers with shape retaining means, e.g. to support the structure of the container during emptying or filling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting

Definitions

  • the present patent application takes the priority of the German patent application DE 10 2014 215 901.6 to complete.
  • the invention relates to a syringe adapter for connecting a dosing syringe to a container for receiving a liquid. Furthermore, the invention relates to a set with at least one container, with a plurality of dosing syringes and with at least one such syringe adapter.
  • Such syringe adapters are used in the metered delivery, for example, a liquid drug from a reservoir into a metering syringe used.
  • Such syringe adapters are already known in various designs.
  • An adapter for sealingly connecting two fluid-carrying components is known from the WO 2011/091895 A1 , In terms of handling and in terms of providing sufficient dosing accuracy, the known syringe adapters still need to be improved.
  • the WO 2011/087 987 A1 discloses a syringe adapter for connecting a dosing syringe to a container.
  • the DE 20 2013 105 808 U1 discloses a device for the removal of medical fluids from designated reservoirs by syringes.
  • the US 2010/0204670 A1 discloses various embodiments of a syringe adapter.
  • the US 5,425,465 describes a syringe adapter for connecting a dosing syringe to a container containing a medicament.
  • the US 4,303,071 describes a syringe adapter for connecting a syringe to a container.
  • the creation of a defined ventilation leads to an improvement of the handling and in particular to the provision of an improved dosing accuracy when using the syringe adapter.
  • the tensile force during the mounting of the metering syringe during the metering is advantageously reduced due to the pressure equalization produced via the ventilation channel.
  • Dosage inaccuracies due to a deformation of the metering syringe, for example, or due to an undesired, pressure-related displacement of a metering piston of the metering syringe are avoided.
  • the formation of unwanted air bubbles in the dosing syringe is also avoided.
  • the syringe adapter can have exactly one ventilation channel, but can also contain several ventilation channels.
  • An adapter body of the syringe adapter on the one hand and the at least one check valve on the other hand are at least partially made of different plastic materials.
  • Such a design of the syringe adapter allows a specific adaptation of adapter sections to their respective function.
  • the syringe adapter can be manufactured in particular with 2K technology. In this case, a soft component for the construction of sealing elements and / or for the construction of the valve components can be used. This soft component can be formed in one piece, which simplifies production of the 2K component.
  • the at least one check valve is designed as disposed in the liquid discharge channel drip stop valve, which opens upon application of a negative pressure at a syringe-side end of the liquid discharge channel and otherwise close. Such a drip stop valve avoids an undesirable escape of the liquid present in the container.
  • At least one further check valve is designed as arranged in the ventilation duct ventilation valve, which opens upon application of a negative pressure at a container-side end of the ventilation duct and otherwise closes. Such a vent valve prevents unwanted liquid from leaking out of the container via the at least one ventilation channel.
  • the syringe adapter has at least one check valve in the fluid delivery channel and at least one further check valve in the ventilation channel.
  • the at least one ventilation valve may be designed with a check valve in the liquid discharge channel as a common component and in particular in one piece.
  • the at least one check valve can also be designed as a slit valve disposed in the liquid discharge channel, which opens in mechanical contact with a suction tip of the dosing syringe and otherwise closes.
  • a slit valve is a simple design and can also ensure a drip stop function.
  • a slit of the slit valve may arise over a predetermined breaking point upon initial mechanical contact with the aspiration tip of the dosing syringe.
  • the slit of the slit valve may be designed as a continuous slit from the beginning.
  • An embodiment as a beak valve according to claim 2 is reliable.
  • Embodiments of the ventilation valve according to claims 3 and 4 have been found to be particularly suitable.
  • a syringe adapter according to claim 5 is particularly simple.
  • the kit may provide syringe adapters for different container sizes and / or may provide different sizes of dosing syringes.
  • a syringe adapter 1 is used to connect a dosing syringe 2 with a container 3 for receiving a liquid, for example for receiving a medical treatment liquid.
  • the container 3 may be a commercially available plastic bottle.
  • the syringe adapter 1 is inserted in the manner of a plug closure in a container neck 4 of the container 3.
  • the syringe adapter 1 is designed as a plastic component.
  • the execution after Fig. 1 shows the syringe adapter 1 executed as a two-component (2K) injection-molded component.
  • a hard component of the syringe adapter 1 comprises a radially projecting support ring 5 with a central opening 6, the edge on a End wall 7 of the container neck 4 rests. From the support ring 5 into the container 3, an inner support structure section 8 of the hard component, in which the opening 6 continues, and an outer support structure section 9 of the hard component extend.
  • the support structure sections 8 and 9 are integrally formed on the support ring 5.
  • the hard component is formed from a polyolefin material, for example polypropylene (PP) or polyethylene (PE).
  • the continuation of the opening 6 in the inner support structure section 8 represents an axially extending liquid discharge channel 6a. This serves to establish a flow connection between an interior of the container 3 and an interior of the dosing syringe 2 as soon as the latter is brought into a connection position relative to the syringe adapter 1.
  • a soft component 10 of the syringe adapter 1 is sprayed onto the holding structure 8, 9.
  • the soft component 10 is embodied as a silicone component.
  • Component of the soft component 10 is a sealing portion surrounding the holding structure 8, 9 radially outside with three circumferential and axially spaced sealing rings 11, which seal the syringe adapter 1 against an inner wall of the container neck 4.
  • the ventilation channels 12, 13 are formed on both sides of the liquid discharge channel 6a.
  • the ventilation channels 12, 13 each serve to create an air connection between the interior of the container 3 and a container environment 14.
  • a check valve 15 is arranged, which in an open position a medium passage, namely a liquid passage, allows, and closes the liquid discharge channel 6a in a closed position.
  • the check valve 15 is designed as a slit valve.
  • the check valve 15 is an integral part of the soft component 10.
  • check valves 16, 17 are executed in the ventilation channels 12, 13.
  • the check valves 16, 17 are each designed as beak valves.
  • the check valves 16, 17 again represent integral portions of the soft component 10 of the syringe adapter 1.
  • the check valves 16, 17 are arranged so that they upon application of a negative pressure at a container-side end of the ventilation channels 12, 13, so when applying a negative pressure inside the Container 3, open and close otherwise.
  • a support base 5 and the support structure 8, 9 comprehensive adapter base body on the one hand and the check valves 15 to 17 on the other hand are thus at least partially made of different plastic materials.
  • the syringe adapter 1 is used as follows:
  • the container 3 is filled with the liquid to be dispensed later.
  • the syringe adapter 1 is placed on the container neck 4 and pressed into this until the support ring 5 rests on the end wall 7 of the container neck 4.
  • the check valves 15 to 17 are all closed.
  • the slit valve 15 may be designed with a first not completely continuous slot, which specifies a desired opening point of the slit valve 15. To fill the metering syringe 2, this is introduced with its suction tip 18 through the opening 6 in the tip adapter 1 until the suction tip 18, the slot valve 15 passes, wherein it opens the slot completely.
  • the liquid present in the container 3 is sucked out of the container 3 into the metering syringe 2 through the liquid discharge channel 6a.
  • the soft component 10 surrounding the slit valve 15 seals the liquid discharge channel 6a against an outer jacket wall of the suction tip 18.
  • the ventilation channels 12, 13 provide for a pressure equalization between the interior of the container 3 and the container environment 14.
  • the non-return arrangement of the beak valves 16, 17 prevents undesired liquid from passing through the ventilation channels 12, 13 to the outside.
  • the dosing syringe 2 After the desired filling of the dosing syringe 2, which can be controlled via a scale on the syringe 2, the dosing syringe 2 is pulled out of the liquid discharge channel 6a, wherein the slit valve 15 closes the liquid discharge channel 6a tightly after pulling out the syringe 2. Undesirable from the liquid discharge channel 6a leaking liquid is thereby avoided. As a result, a drip stop function of the slit valve 15 is given.
  • the liquid discharge channel 6a is designed with respect to the channel diameter and the dimensions of the slit valve 15 exactly matching an outer contour of the metering syringe 2 in the region of the suction syringe 18. Dead volumes in the liquid discharge channel 6a, in which liquid can settle without passing from the interior of the container 3 into the interior of the metering syringe 2, are thereby avoided.
  • the check valves 15 to 17 also prevent leakage of the liquid from the interior of the container 3 in a possibly necessary shaking the liquid in the container 3 before the liquid is dispensed into the metering syringe. 2
  • Fig. 2 shows a further embodiment of a syringe adapter 19, which can be used in place of the syringe adapter 1.
  • the check valve 15 in the liquid discharge channel 6a of the syringe adapter 19 is designed as a beak valve.
  • the beak valve 15 is made of silicone.
  • the beak valve 15 is arranged so that it opens when a negative pressure at a syringe-side end of the liquid discharge channel 6a, ie when sucking on the metering syringe 2, and otherwise closes.
  • the two further non-return valves 16, 17 in the ventilation channels 12, 13 are designed as umbrella valves, each having a valve body 20 and a valve seat 21. In the presence of a container side Vacuum lifts the respective valve seat 21 from the valve body 20 of the umbrella valve 16 or 17 and thus enables a pressure equalization between the interior of the container 3 and the container environment.
  • the umbrella valves 16, 17 are also made of silicone.
  • the beak valve 15 and the two umbrella valves 16, 17 may be integral portions of a soft component of the syringe adapter 19.
  • Fig. 3 shows a further embodiment of a syringe adapter 24, which can be used in place of the syringe adapter 1.
  • a syringe adapter 24 which can be used in place of the syringe adapter 1.
  • the liquid discharge channel 6a is not centrally in the syringe adapter 24 before, but decentred.
  • the syringe adapter 24 has only one ventilation channel 12, so no two ventilation channels as the syringe adapter versions of the Fig. 1 and 2 ,
  • the beak valve 16 In the ventilation channel 12 of the syringe adapter 24 is again a check valve in the manner of the beak valve 16 of the embodiment as a check valve Fig. 1 arranged. Unlike the syringe adapter 1, the beak valve 16 is arranged at the height of the support ring 5 at the syringe adapter 24. The function of the beak valve 16 remains the same.
  • Fig. 4 shows a further embodiment of a syringe adapter 25, which can be used in place of the syringe adapter 1.
  • the ventilation channels 12, 13 run in steps and, in addition to axially extending sections, also each have a radially extending section 12a, 13a. Via these radially extending ventilation channel sections 12a, 13a and adjoining axial end sections 12b, 13b, the ventilation channels 12, 13 open when the syringe adapter 25 is inserted into the interior of the container 3.
  • the channel sections 12b, 13b extend radially adjacent to the liquid discharge channel 6a. In this area, a hybrid valve 26 is arranged.
  • the hybrid valve 26 has as one-piece component on the one hand the function of the beak valve 15th in the liquid discharge channel 6a and on the other hand, the function of the check valves 16, 17 in the ventilation channels 12, 13, as described above with reference to the embodiments of the Fig. 1 and 2 already explained.
  • the hybrid valve 26 has a valve seat 27, which stands in the presence of a negative pressure inside the container 3 in comparison to the container environment 14 from the discharge openings of the channel sections 12b, 13b and thus a pressure equalization between the interior of the container 3 and the container environment fourteenth allows.
  • Fig. 5 shows another example of a syringe adapter 29, which can be used in place of the syringe adapter 1.
  • a ventilation channel is performed by a radially extending channel portion 12c between the liquid discharge channel 6a and a radially outer jacket wall of the syringe adapter 29, the channel portion 12c axially between two of the sealing rings 11 opens.
  • Another portion of the ventilation channel is formed by an axially extending channel portion 12d, which is performed through the support ring 5 therethrough.
  • the sealing ring 11 between the channel portion 12b and the channel portion 12c may have a ventilation recess.
  • syringe adapter 29 is a hybrid valve according to the hybrid valve 26 of the embodiment Fig. 4 in front.
  • To ensure the ventilation function lifts a valve seat 27 of the hybrid valve 26 of the syringe adapter 29 for releasing an edge-side ventilation path between the liquid discharge channel 6 a and the interior of the container 3 from.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP15178923.7A 2014-08-11 2015-07-29 Spritzenadapter Active EP2985015B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP17184242.0A EP3260108A1 (de) 2014-08-11 2015-07-29 Spritzenadapter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102014215901.6A DE102014215901A1 (de) 2014-08-11 2014-08-11 Spritzenadapter

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP17184242.0A Division EP3260108A1 (de) 2014-08-11 2015-07-29 Spritzenadapter
EP17184242.0A Division-Into EP3260108A1 (de) 2014-08-11 2015-07-29 Spritzenadapter

Publications (2)

Publication Number Publication Date
EP2985015A1 EP2985015A1 (de) 2016-02-17
EP2985015B1 true EP2985015B1 (de) 2017-09-27

Family

ID=53783089

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15178923.7A Active EP2985015B1 (de) 2014-08-11 2015-07-29 Spritzenadapter
EP17184242.0A Withdrawn EP3260108A1 (de) 2014-08-11 2015-07-29 Spritzenadapter

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17184242.0A Withdrawn EP3260108A1 (de) 2014-08-11 2015-07-29 Spritzenadapter

Country Status (6)

Country Link
US (1) US10363199B2 (es)
EP (2) EP2985015B1 (es)
DE (1) DE102014215901A1 (es)
DK (1) DK2985015T3 (es)
ES (1) ES2647364T3 (es)
NO (1) NO3164632T3 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021204338A1 (de) 2021-04-30 2022-11-03 Raumedic Ag Dosiersystem zur Einstellung eines Dosiervolumens eines fließfähigen Mediums sowie Spritzenadapter als Bestandteil eines derartigen Dosiersystems

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US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
EP2459146B1 (en) 2009-07-29 2020-04-29 ICU Medical, Inc. Fluid transfer methods
AU2012296495B2 (en) 2011-08-18 2016-03-10 Icu Medical, Inc. Pressure-regulating vial adaptors
MX352988B (es) 2012-01-13 2017-12-15 Icu Medical Inc Adaptadores de frasco reguladores de presión y métodos.
AU2013204180B2 (en) 2012-03-22 2016-07-21 Icu Medical, Inc. Pressure-regulating vial adaptors
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
ES2966008T3 (es) 2013-01-23 2024-04-17 Icu Medical Inc Adaptadores de vial de regulación de presión
CA3179530A1 (en) 2013-07-19 2015-01-22 Icu Medical, Inc. Pressure-regulating fluid transfer systems and methods
AU2014353184B2 (en) 2013-11-25 2017-08-17 Icu Medical, Inc. Methods and system for filling IV bags with therapeutic fluid
EP3157491B1 (en) 2014-06-20 2022-06-22 ICU Medical, Inc. Pressure-regulating vial adaptors
EP3383343A4 (en) 2015-12-04 2019-07-10 ICU Medical, Inc. SYSTEMS, METHODS AND COMPONENTS FOR TRANSFERRING MEDICAL LIQUIDS
DK3397231T3 (da) 2016-01-29 2022-05-16 Icu Medical Inc Trykregulerende hætteglasadaptere
EP3419582B1 (en) 2016-02-24 2022-07-13 Avent, Inc. Fluid transfer connector
USD851745S1 (en) 2016-07-19 2019-06-18 Icu Medical, Inc. Medical fluid transfer system
JP7046051B2 (ja) 2016-07-25 2022-04-01 アイシーユー・メディカル・インコーポレーテッド 医療用流体移送モジュールおよびシステムの中の空気バブルをトラップするためのシステムおよびコンポーネント
EP3518860A4 (en) 2016-09-30 2020-06-10 ICU Medical, Inc. DEVICES AND METHODS FOR ACCESSING PRESSURE REGULATING VIALS
IT201700032091A1 (it) * 2017-03-23 2018-09-23 Bormioli Pharma S R L Riduttore per siringa
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
WO2022271578A1 (en) * 2021-06-21 2022-12-29 Vertice Pharma Llc Adapter for clinical, medical and laboratory containers

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US4303071A (en) * 1978-08-07 1981-12-01 Baxa Corporation Syringe-type liquid container dispenser adapter

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US5425468A (en) 1993-02-26 1995-06-20 Birkel; Dianne B. Multi-purpose secretion receptacle
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US9296531B2 (en) 2010-01-12 2016-03-29 Medela Holding Ag Container with sealed cap and venting system
DE102010001225A1 (de) 2010-01-26 2011-07-28 Raumedic Ag, 95213 Dicht-Hülsenkörper
DE202013105808U1 (de) * 2013-12-19 2014-01-23 Rowemed Ag Medical 4 Life Vorrichtung zur Entnahme von medizinischen Flüssigkeiten aus dafür vorgesehenen Vorratsbehältern mittels Spritzen

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Publication number Priority date Publication date Assignee Title
US4303071A (en) * 1978-08-07 1981-12-01 Baxa Corporation Syringe-type liquid container dispenser adapter

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021204338A1 (de) 2021-04-30 2022-11-03 Raumedic Ag Dosiersystem zur Einstellung eines Dosiervolumens eines fließfähigen Mediums sowie Spritzenadapter als Bestandteil eines derartigen Dosiersystems

Also Published As

Publication number Publication date
EP3260108A1 (de) 2017-12-27
US20160038374A1 (en) 2016-02-11
NO3164632T3 (es) 2018-07-14
US10363199B2 (en) 2019-07-30
DE102014215901A1 (de) 2016-02-11
ES2647364T3 (es) 2017-12-21
EP2985015A1 (de) 2016-02-17
DK2985015T3 (en) 2018-01-08

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