EP2967850A1 - Appareil perfectionné à feuillet et valvule - Google Patents

Appareil perfectionné à feuillet et valvule

Info

Publication number
EP2967850A1
EP2967850A1 EP14708735.7A EP14708735A EP2967850A1 EP 2967850 A1 EP2967850 A1 EP 2967850A1 EP 14708735 A EP14708735 A EP 14708735A EP 2967850 A1 EP2967850 A1 EP 2967850A1
Authority
EP
European Patent Office
Prior art keywords
leaflet
prosthetic valve
guiding element
valve
layers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14708735.7A
Other languages
German (de)
English (en)
Inventor
William C. Bruchman
Cody L. Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WL Gore and Associates Inc
Original Assignee
WL Gore and Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/183,251 external-priority patent/US20140163671A1/en
Application filed by WL Gore and Associates Inc filed Critical WL Gore and Associates Inc
Publication of EP2967850A1 publication Critical patent/EP2967850A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0029—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in bending or flexure capacity

Definitions

  • Valve durability under the repetitive loads of the leaflets opening and closing is dependent, in part, on the dynamic characteristics of the leaflets. Thin leaflets can develop folds that repeatedly form in the central portion of the leaflet during the opening and closing action of the valve, often times resulting in the formation of a hole within the leaflet at a site of repeated bending stress.
  • the present invention comprises apparatus and systems for valve replacement or augmentation, such as cardiac valve replacement.
  • the present invention is directed towards leaflet design or modifications and leaflet-type cardiac valves that not only improve upon conventional prosthetic valve hemodynamics, but also reduce the incidence of premature leaflet failure. Stated otherwise, the leaflet designs contemplated herein demonstrate improved performance and improved longevity in valve leaflets that would otherwise exhibit tight-radius buckling.
  • a prosthetic valve comprises a frame, at least one leaflet, and a guiding element.
  • Each leaflet comprises a plurality of layers of film coupled together.
  • Each leaflet defines a leaflet base, a leaflet edge portion opposite the leaflet base, and a central portion between the leaflet base and the leaflet edge portion.
  • Each leaflet is coupled to the frame along at least a portion of the leaflet base.
  • Each leaflet is pivotable between an open position and a closed position.
  • the central portion has a greater stiffness than at least one of the leaflet edge portion and the leaflet base.
  • the one or more guiding elements have a length which is aligned radiating away from but spaced apart from the leaflet base such that the leaflet pivots substantially from the leaflet base when the leaflet is deployed in the prosthetic valve and the prosthetic valve is operated so as to flex the leaflet.
  • FIG. 1 A is a top view of an embodiment of a valve in a closed
  • FIG. 1B is an axial view of an embodiment of the valve of FIG. 1A in an open configuration, in accordance with an embodiment
  • FIG. 2 is a perspective view of an embodiment of a valve in a closed configuration, in accordance with an embodiment
  • FIG. 5 is an axial view of an embodiment of a valve having leaflets comprising a guiding element, in accordance with an embodiment
  • FIG. 12 is a cross-sectional view of a guiding element between layers of film, in accordance with an embodiment
  • embodiments within the scope of this disclosure can be applied toward any valve or mechanism of similar structure and/or function. Furthermore, embodiments within the scope of this disclosure can be applied in non -cardiac applications.
  • composite material refers to a combination of a membrane, such as, but not limited to, expanded fluoropolymer, and an elastomer, such as, but not limited to, a fluoroelastomer.
  • a membrane such as, but not limited to, expanded fluoropolymer
  • an elastomer such as, but not limited to, a fluoroelastomer.
  • the elastomer can be imbibed within a porous structure of the membrane, coated on one or both sides of the membrane, or a combination of coated on and imbibed within the membrane.
  • T e term laminate refers to multiple layers of membrane, composite material, or other materials, such as elastomer, and combinations thereof.
  • film as used herein generically refers to one or more of the membrane, composite material, or laminate.
  • leaflet window is defined as that space that a frame defines from which a leaflet extends.
  • the leaflet may extend from frame elements or adjacent to frame elements and spaced apart therefrom.
  • native valve orifice and tissue orifice refer to an anatomical structure into which a prosthetic valve may be placed.
  • Such anatomical structure includes, but is not limited to, a location wherein a cardiac valve may or may not have been surgically removed.
  • other anatomical structures that can receive a prosthetic valve include, but are not limited to, veins, arteries, ducts and shunts.
  • a valve orifice or implant site may also refer to a location in a synthetic or biological conduit that may receive a valve.
  • Couple means to join, connect, attach, adhere, affix, or bond, whether directly or indirectly, and whether permanently or temporarily.
  • leaflet embodiments presented herein provide improved leaflet bending, and thereby improved lifetime and improved hemodynamics.
  • Embodiments provided herein are related to prosthetic heart valve leaflets comprising one or more guiding elements that allow for control of the movement of the leaflets, such as, but not limited to, controlling the bending characteristics of the leaflet.
  • a prosthetic valve comprises a plurality of polymer leaflets.
  • the polymer leaflets comprise a laminate of multiple layers of membrane, composite material, or other materials, such as elastomer, and combinations thereof.
  • One or more guiding elements are coupled to and contained within the laminate lying between two of the multiple layers of membrane or composite material.
  • the guiding element is operable to provide a structural influence on the leaflet such as to control the bending characteristics of the leaflet. Since the guiding element is fully contained within the laminate layers, the guiding element remains permanently coupled to the leaflet. Further, since the guiding element is fully contained within the laminate layers, the guiding element is not exposed to the blood stream.
  • FIG. 1 Another embodiment is directed towards a prosthetic valve comprising a leaflet support member and at least one leaflet as described above wherein the leaflet is connected to the support member along the base portion of the leaflet.
  • the leaflet is movable between a first position and a second position, such that in the first position, the valve is a flow occluder and in the second position, the valve is a flow orifice.
  • the valve further comprises a guiding element, as described herein, connected to at least one leaflet.
  • at least one leaflet 140 may not have a guiding element 150, while at least one leaflet does comprise a guiding element 150.
  • the valve comprises a compressed configuration and an expanded configuration.
  • a valve can be compressible or crushable under the application of a binding or compression force to obtain a compressed configuration.
  • a support member may comprise a shape memory material.
  • a compressible valve may be implanted via endovascular techniques now known or hereinafter derived.
  • FIGS. 1 A and 1 B are axial views of a valve 100 in the closed and open condition, respectively, in accordance with an embodiment.
  • FIG. 2 is a perspective view of the valve 100 in the closed condition.
  • the valve 100 comprises a frame 130 and a film 160 covering the frame 130 forming the leaflets 140 coupled to the frame 130, in accordance with an embodiment.
  • FIG. 3 is a perspective view of the frame 130, in accordance with an embodiment.
  • a film 160 generically refers to one or more of the membrane, composite material, or laminate as previously defined.
  • the leaflets 140 are comprised of the film 160. Details of various types of film 160 are discussed below.
  • the film 160 can be formed from a generally tubular material to couple the frame 130 and to form the leaflets 140.
  • the laminate comprises a number of layers of membrane and/or composite material, with the guiding element 150 being coupled and contained within at least two layers of membrane and/or composite material.
  • the film 160 comprises a biocompatible polymer that is combined with an elastomer, referred to as a composite.
  • a material according to one embodiment includes a composite material comprising an expanded
  • fluoropolymer membrane which comprises a plurality of spaces within a matrix of fibrils, and an elastomeric material.
  • elastomeric material can include multiple elastomers, multiple types of non-elastomeric components, such as inorganic fillers, therapeutic agents, radiopaque materials, and the like while remaining within the scope of the present disclosure.
  • the expanded fluoropolymer membrane can comprise any suitable microstructure for achieving the desired leaflet performance.
  • the expanded fluoropolymer comprises a microstructure of nodes interconnected by fibrils, such as described in U.S. Patent No. 3,953,566 to Gore.
  • the fibrils radiaHy extend from the nodes in a plurality of directions, and the membrane has a generally homogeneous structure.
  • Membranes having this microstructure may typically exhibit a ratio of matrix tensile strength in two orthogonal directions of less than 2, and possibly less than 1.5.
  • the expanded fluoropolymer membrane can be tailored to have any suitable thickness and mass to achieve the desired leaflet performance.
  • the leaflet 140 comprises an expanded
  • the expanded fluoropolymer membrane having a thickness of about 0.1 ⁇ .
  • the expanded fluoropolymer membrane can possess a mass per area of about 1.15 g m 2 .
  • Membranes according to an embodiment of the invention can have matrix tensile strengths of about 411 MPa in the longitudinal direction and 315 MPa in the transverse direction.
  • a method of filling the pores of the expanded fluoropolymer membrane includes the steps of polymerizing the elastomer within the pores of the expanded fluoropolymer membrane by first filling the pores with a prepolymer of the elastomer and then at least partially curing the elastomer.
  • the leaflets constructed from fluoropolymer materials or ePTFE generally performed better with increasing percentages of elastomer resulting in significantly increased cycle lives.
  • the elastomer combined with the ePTFE is a thermoplastic copolymer of tetrafluoroethylene and perfluoromethyl vinyl ether, such as described in U.S. Patent No. 7,462,675 to Chang et al., and other references that would be known to those of skill in the art.
  • FIG. 3 is a perspective view of the frame 130 in the embodiment of FIGS. 1 A and 1 B.
  • the frame 130 is a generally tubular member defining a valve orifice 102 and providing structural, load-bearing support to the leaflet 140.
  • the frame 130 can be configured to provide positive engagement to the recipient tissue at the implantation site.
  • the frame 130 can comprise any metallic or polymeric biocompatible material.
  • the frame 130 can comprise a material, such as, but not limited to nitinol, cobalt-nickel alloy, stainless steel, and polypropylene, acetyl homopolymer, acetyl copolymer, ePTFE, other alloys or polymers, or any other biocompatible material having adequate physical and mechanical properties to function as described herein.
  • the frame 130 defines a stent having apertures 122.
  • the open framework of the stent can define any number of features, repeatable or otherwise, such as geometric shapes and/or linear or meandering series of sinusoids.
  • An open framework can be etched, cut, laser cut, or stamped into a tube or a sheet of material, with the sheet then formed into a substantially cylindrical structure.
  • the frame 130 can have a solid wall.
  • an elongated material such as a wire, bendable strip, or a series thereof, can be bent or braided and formed into a substantially cylindrical structure.
  • the frame 130 can comprise, such as, but not limited to, an elastically deformable metallic or polymeric biocompatible material.
  • the frame 130 can comprise a shape-memory material, such as nitinol, a nickel-titanium alloy.
  • Other materials suitable for the frame 130 include, but not limited to, other titanium alloys, stainless steel, cobalt-nickel alloy, polypropylene, acetyl homopolymer, acetyl copolymer, other alloys or polymers, or any other biocompatible material having adequate physical and mechanical properties to function as a frame 130 as described herein.
  • the film 160 can be coupled to the frame 130 in many ways suitable for a particular purpose.
  • the frame 130 can be wrapped with overlapping layers of the film 160.
  • the film 160 can be coupled to the frame outside surface 133a or the frame inside surface 133b of the frame 130. In another embodiment, the film 160 can be coupled to either of the frame outside surface 133a or the frame inside surface 133b.
  • the film 160 is fixedly secured or otherwise coupled at a single or a plurality of locations of the frame outside surface 133a and the frame inside surface 133b of the frame 130, for example, using one or more of taping, heat shrinking, adhesion and other processes known in the art.
  • a plurality of membrane composite layers such as, but not limited to a laminate, are used and can be coupled to the frame 130 to form at least a portion of the film 160.
  • Fluid flow is permitted through the valve orifice 102 when the leaflets 140 are in an open position as shown in FIG. 1 B.
  • the leaflets 140 generally flex about the base 134 of the U-shaped portion 132 as the leaflets 140 open and close, as shown in FIG. 3.
  • when the valve 100 is closed generally about half of each leaflet free edge 142 abuts an adjacent half of a leaflet free edge 142 of an adjacent leaflet 140, as shown in FIG. 2.
  • a leaflet thickness may range from about 10 m to about 100 pm but again such thickness may vary from the above stated ranges depending on the size, material, and desired function of the leaflet. As discussed below, improvements in accordance with the present embodiments may provide for leaflet thicknesses outside of conventional thicknesses.
  • FIG. 5 is an axial view of a representation of a valve 101.
  • a leaflet edge portion 113 comprises a coaptation region 146 of the leaflet 140.
  • a central portion 147 comprises an area between a leaflet base 135 and the leaflet edge portion 113.
  • a coaptation region 146 is the area comprising the junction formed between two leaflets 140 in the closed position.
  • the leaflet 140 also comprises a vertical axis X1.
  • the height of the leaflet 140 is the length of the leaflet 140 along a line parallel to the vertical axis X1.
  • the width of the leaflet 140 is the length of the leaflet 140 along a line perpendicular to the vertical axis X1 , which may vary between the leaflet base 135 and the leaflet free edge 142.
  • the guiding element defines a guiding element length and the leaflet defines a leaflet length extending from the leaflet base and the edge portion, the guiding element length being less than the leaflet length.
  • the guiding element improves both the longevity, such as, but not limited to, durability, and the hemodynamic performance of the valve.
  • the motion of the central portion 147 of the leaflet 140 between the first position and the second position substantially follows the guiding element 150.
  • the amplitude or number of sigmoid, or S-shaped, curves formed on the leaflet about the vertical axis X1 during the transition may be reduced, and a majority of such curves are formed closer to the leaflet edge portion 113 and the leaflet base 135 of the leaflet 140 and in a more controlled manner.
  • the motion of a point on the guiding element 150 may exist substantially on a plane, substantially on an arc, and in an embodiment, substantially on an elliptical arc.
  • the motion of the guiding element 150 as a whole tracks a substantially planar pivoting surface while transitioning between the first position and the second position.
  • the guiding element 150 may comprise a plurality of materials, and thereby exhibit a variable resistance to deformation along its length or width.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Manufacturing & Machinery (AREA)

Abstract

La présente invention concerne un feuillet (140) destiné à être utilisé dans une valvule prothétique (100) qui stabilise le mouvement du feuillet lorsqu'elle se déplace entre une position fermée et une position ouverte. Selon des modes de réalisation, une valvule prothétique comprend un feuillet (140) qui contient un élément de renforcement (150) entre des couches de film à partir duquel est réalisé le feuillet.
EP14708735.7A 2013-03-15 2014-02-19 Appareil perfectionné à feuillet et valvule Withdrawn EP2967850A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361800402P 2013-03-15 2013-03-15
US14/183,251 US20140163671A1 (en) 2011-04-01 2014-02-18 Leaflet and valve apparatus
PCT/US2014/017118 WO2014149319A1 (fr) 2013-03-15 2014-02-19 Appareil perfectionné à feuillet et valvule

Publications (1)

Publication Number Publication Date
EP2967850A1 true EP2967850A1 (fr) 2016-01-20

Family

ID=50238472

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14708735.7A Withdrawn EP2967850A1 (fr) 2013-03-15 2014-02-19 Appareil perfectionné à feuillet et valvule

Country Status (8)

Country Link
EP (1) EP2967850A1 (fr)
JP (1) JP2016510645A (fr)
KR (1) KR20150130300A (fr)
CN (1) CN105050544A (fr)
AU (1) AU2014238323B2 (fr)
CA (1) CA2900676A1 (fr)
HK (1) HK1215999A1 (fr)
WO (1) WO2014149319A1 (fr)

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Publication number Priority date Publication date Assignee Title
EP2866847B1 (fr) 2012-07-02 2018-08-22 Boston Scientific Scimed, Inc. Formation de prothèse valvulaire cardiaque
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US10299915B2 (en) 2015-04-09 2019-05-28 Boston Scientific Scimed, Inc. Synthetic heart valves composed of zwitterionic polymers
US10426609B2 (en) 2015-04-09 2019-10-01 Boston Scientific Scimed, Inc. Fiber reinforced prosthetic heart valve having undulating fibers
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
US10413403B2 (en) 2015-07-14 2019-09-17 Boston Scientific Scimed, Inc. Prosthetic heart valve including self-reinforced composite leaflets
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US10022223B2 (en) 2015-10-06 2018-07-17 W. L. Gore & Associates, Inc. Leaflet support devices and methods of making and using the same
CN109475409B (zh) 2016-05-19 2021-02-19 波士顿科学国际有限公司 人工瓣膜、瓣膜小叶和相关方法
US10925998B2 (en) 2017-04-25 2021-02-23 Boston Scientific Scimed, Inc. Method of manufacturing a biocompatible composite material
CA3155761A1 (fr) 2017-09-27 2019-04-04 W.L. Gore & Associates, Inc. Valves prothetiques a lames valvulaires mecaniquement accouplees
JP7068444B2 (ja) 2017-09-27 2022-05-16 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 拡張可能なフレームを備えた人工弁、並びに関連するシステム及び方法
JP7381601B2 (ja) * 2019-04-12 2023-11-15 エドワーズ ライフサイエンシーズ コーポレイション マルチパートフレーム及び関連するレジリエントブリッジ特徴部を備えた弁
WO2023133724A1 (fr) * 2022-01-12 2023-07-20 金仕生物科技（常熟）有限公司 Valve d'intervention pouvant être implantée sous guidage d'imagerie ultrasonore

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US6283994B1 (en) * 1999-04-16 2001-09-04 Sulzer Carbomedics Inc. Heart valve leaflet
DE60124930T2 (de) * 2000-09-21 2007-09-20 St. Jude Medical, Inc., St. Paul Ventilprothesen mit blattelementen aus verstärktem kunststoff
US6602286B1 (en) * 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US20120116496A1 (en) * 2010-11-05 2012-05-10 Chuter Timothy A Stent structures for use with valve replacements
EP2522308B1 (fr) * 2011-05-10 2015-02-25 Biotronik AG Prothèse de valvule mécanique à transcathéter

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Also Published As

Publication number Publication date
AU2014238323A1 (en) 2015-08-20
JP2016510645A (ja) 2016-04-11
CN105050544A (zh) 2015-11-11
WO2014149319A1 (fr) 2014-09-25
AU2014238323B2 (en) 2017-03-09
CA2900676A1 (fr) 2014-09-25
HK1215999A1 (zh) 2016-10-07
KR20150130300A (ko) 2015-11-23

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