EP2962956B1 - Vorratsbehälter für eine Vorrichtung zum automatisierten Abgeben einzelner Medikamentenportionen - Google Patents

Vorratsbehälter für eine Vorrichtung zum automatisierten Abgeben einzelner Medikamentenportionen Download PDF

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Publication number
EP2962956B1
EP2962956B1 EP14175587.6A EP14175587A EP2962956B1 EP 2962956 B1 EP2962956 B1 EP 2962956B1 EP 14175587 A EP14175587 A EP 14175587A EP 2962956 B1 EP2962956 B1 EP 2962956B1
Authority
EP
European Patent Office
Prior art keywords
rotor
storage container
recess
opening
medication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14175587.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2962956A1 (de
Inventor
Dietmar Gross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson Rowa Germany GmbH
Original Assignee
Becton Dickinson Rowa Germany GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PT141755876T priority Critical patent/PT2962956T/pt
Application filed by Becton Dickinson Rowa Germany GmbH filed Critical Becton Dickinson Rowa Germany GmbH
Priority to ES14175587.6T priority patent/ES2609060T3/es
Priority to EP14175587.6A priority patent/EP2962956B1/de
Priority to DK14175587.6T priority patent/DK2962956T3/en
Priority to CA2953650A priority patent/CA2953650C/en
Priority to PCT/EP2015/063463 priority patent/WO2016000954A1/de
Priority to KR1020177000470A priority patent/KR102423995B1/ko
Priority to AU2015283080A priority patent/AU2015283080B2/en
Priority to BR112016030617-1A priority patent/BR112016030617B1/pt
Priority to JP2017519799A priority patent/JP2017523013A/ja
Priority to MX2016016772A priority patent/MX356673B/es
Publication of EP2962956A1 publication Critical patent/EP2962956A1/de
Application granted granted Critical
Publication of EP2962956B1 publication Critical patent/EP2962956B1/de
Priority to JP2019237783A priority patent/JP6937360B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076Medicament distribution means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B35/00Supplying, feeding, arranging or orientating articles to be packaged
    • B65B35/06Separating single articles from loose masses of articles
    • B65B35/08Separating single articles from loose masses of articles using pocketed conveyors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00Containers or packages with special means for dispensing contents
    • B65D83/04Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
    • B65D83/0409Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills the dispensing means being adapted for delivering one article, or a single dose, upon each actuation

Definitions

  • the present application relates to a storage container for individual portions of medication, and more particularly to a storage container for a device for the automated dispensing of individual portions of medication.
  • Devices for the automated dispensing of individual portions of medicaments are used in blister machines used in particular in hospitals and blister centers, with which medicament portions are blistered patient-specifically in accordance with the medically prescribed administration times / combinations.
  • Corresponding blister machines contribute to the optimization of drug management and drug logistics. With modern blister machines, the individual medication portions are blistered patient-specifically within a very short time, with a very small number of operators.
  • the different portions of medication blistered with the blister machines are stored in a variety of devices for automatically dispensing individual portions of medication, and a single blister machine may include several hundred of such devices, depending on the site requirements.
  • the devices for the automated dispensing of individual medication portions usually comprise two main components, namely a storage container for storing the individual medication portions, wherein this storage container comprises, inter alia, at least part of a separation device necessary for dispensing individual medication portions, and a container receptacle on which the container is mounted.
  • This container receptacle can also be parts of the separating device (for example, the engine and / or a Control device).
  • the two main components of the device for dispensing individual medication portions are separate components, but it is also conceivable to carry out the device in one piece.
  • the device for dispensing individual medicament portions is usually attached to the blister machine via the container receptacle. If the reservoir needs to be refilled or the medicines are to be changed in the reservoir usually only the reservoir is removed from the container receptacle and it will be filled at a filling station new drugs.
  • the contamination particles impair the mechanics within the reservoir and settle in it.
  • care must be taken to ensure that it is intensively cleaned, so that it is avoided that drug residues of a previously stored in the reservoir drug in another, subsequently stored drug through the singulator from the Reservoir be discharged, and, in extreme cases, be blistered with.
  • US 2013/0292406 describes a reservoir with a singulator.
  • the reservoir according to the invention comprises a housing enclosing a receiving space with a bottom surface, wherein the individual medicament portions are mounted in the receiving space.
  • a separating device is arranged with at least one channel for receiving at least one medication portion, the at least one channel having an opening facing the receiving space and an opening facing the bottom surface, wherein the opening facing the bottom surface is associated with a contact area on the bottom plate which the medication portions are guided during a movement of the separating device.
  • the separating device in the storage container may comprise all components which are necessary for the separation of medicament portions stored in the receiving space.
  • the singulating device of the reservoir according to the invention may also comprise only a part of the components of the singling device, wherein other parts (for example the drive and a control) are arranged in the container receptacle.
  • the term "separating device” encompasses "complete” separating devices and only partial separating devices, ie those separating devices which do not include all the parts necessary for singling.
  • the storage container according to the invention further comprises at least one well disposed in the bottom surface outside the contact surface for receiving impurity particles present in the container.
  • the medication portions During singulation, the medication portions reach the opening of the channel facing the receiving space in the latter and further through the channel to that of the bottom surface Opening the channel where they rest in the contact area on the floor surface. If a single medication portion is requested, the portion of medication in the channel at the opening facing the opening and resting on the contact area of the bottom surface with the singulator is extended over the contact area to an opening (which may also be part of the singler) in the housing (s) Floor surface out over which the medication portion leaves the reservoir.
  • an opening which may also be part of the singler
  • Impurity particles arise firstly during filling of the receiving space with individual medication portions and secondly during the separation itself, for example, when a single portion of medication strikes or is guided over the contact area of the bottom surface during the separation.
  • the reservoir In the operation of the blister machine, in particular when singulating, the reservoir is constantly exposed to slight vibrations, which ensure that the contaminant particles are constantly moved on the floor surface.
  • the vibration-induced movements of the contaminant particles they inevitably get to and into the at least one depression in the bottom surface in which they are held.
  • care is taken to ensure that contamination particles, which inevitably arise during operation, are constantly "captured”.
  • the impurity particles trapped in the well can no longer be discharged or disturb the mechanics, effectively reducing the general contamination by contaminant particles.
  • the singulation device can operate according to principles known to the person skilled in the art and can be constructed accordingly.
  • the separating device has only one channel for receiving a single portion of medication, wherein the channel is movable into a receiving position, in which the opening of the channel facing the receiving space, and in a dispensing position, in which the receiving space facing opening of the channel closed and the bottom surface facing opening is open to a discharge opening in the housing / the bottom surface.
  • the separating device comprises a rotor arranged on the bottom surface with a plurality of channels, wherein the rotor is arranged such that between the underside of the rotor and the bottom surface, a gap is provided through which impurity particles can pass through.
  • the arrangement of the channels in the rotor is dependent on the exact structural design of the singulator, but it is preferred that the channels are arranged on the outer circumference of the rotor and open to the outside, d. H. the channels are formed by a plurality of webs on the circumference of the rotor.
  • the housing is then adapted to the rotor, that a special portion of the housing is adapted to receive the rotor and has a corresponding circular cylindrical portion whose diameter is slightly larger than the outer diameter of the rotor.
  • Correspondingly arranged channels are easier to clean. Furthermore, the entry of medication portions into the channels is facilitated by a corresponding formation of the top of the rotor.
  • the particles of contamination due to the vibrations of the Reservoir moves to the at least one recess in the bottom surface.
  • at least a portion of the floor area funnel-shaped, wherein the rotor of the separating device is arranged in the center of the funnel-shaped portion and the at least one formed in the bottom surface recess between the center of the funnel-shaped portion and the contact region is arranged.
  • the at least one recess is thus formed within the annular contact area, so that the impurity particles are moved or directed to the at least one depression not only by the vibration of the reservoir, but also by gravity due to the inclination of the funnel-shaped portion.
  • the at least one recess is formed as a groove coaxial with the rotor axis.
  • the exact configuration of the depression or the depressions is dependent on the special construction of the separating device.
  • the recess may be annular, ie. H. that a groove formed as a groove surrounds the entire center of the funnel-shaped portion and is ensured so that as many impurity particles are absorbed.
  • it may be necessary that the recess is formed only as a ring portion and a certain angular range remains free, in which no recess is arranged.
  • the rotor at its the Bottom surface facing bottom comprises a plurality of cleaning agents that feed contaminant particles of at least one recess.
  • cleaning agents may be designed, for example, as small brushes, which are formed as a function of the direction of rotation of the rotor on the underside of the rotor.
  • the rotor can be mounted, for example, on a rotor axis penetrating the bottom surface.
  • a circular, coaxial to the rotor axis projection is formed on the bottom surface, wherein the at least one recess outside the area enclosed by the projection bottom surface is arranged.
  • the reservoir according to the invention In order to further accelerate the movement of the contaminant particles on the bottom surface towards the depression and to prevent the contamination particles from settling on the bottom surface itself, it is provided in a preferred embodiment of the reservoir according to the invention that at least a portion of the bottom surface is coated with a non-stick coating.
  • the contaminant particles reach the at least one depression, inter alia, due to the vibrations occurring during operation.
  • the reservoir contains a vibration device which actively exposes the reservoir to vibrations to actively contaminate the contaminant particles formed during operation to the at least one recess to move.
  • Figure 1A shows an oblique view of the embodiment of the storage container 1 according to the invention for a device for the automated dispensing of individual medication portions.
  • the storage container shown is merely a part of the aforementioned device, which comprises a container receptacle as a further main component.
  • the container receptacle is not part of the present application and will not be discussed in detail here.
  • the storage container 1 comprises a housing with a plurality of housing sections, namely with an upper storage section 3a, a central circular cylindrical section 3b for receiving a part of the singulator, a lower floor section 3c and a handle section 3d.
  • the upper portion 3a is closed with a cover 5.
  • FIG. 2 shows a further oblique view of the embodiment, wherein in this illustration, the lid for better insight into the reservoir is omitted.
  • a rotor 101 which is part of a separating device 100, can be seen in the circular-cylindrical section 3b of the housing.
  • the rotor 101 comprises (see in particular FIG. 9B ) a plurality of channels 102 which are arranged outwardly open at the periphery of the rotor by webs 108 separated from each other and having an upper opening 103 and a lower opening 104.
  • the rotor 101 itself is how to do this FIG. 9B stored on a rotor axis 106 which extends through the bottom surface 104 (see FIG. 1B ).
  • a further housing portion 3e which is formed obliquely to the rotor 101 out.
  • the housing sections 3a and 3e and the rotor 101 define a receiving space 2, in which individual medication portions are stored in the operating state.
  • FIG. 3 shows a plan view of the housing of the first embodiment of the storage container according to the invention, wherein in this embodiment, parts of the singulator 100 are omitted, including the rotor 101 and the rotor axis 106.
  • the circular cylindrical section 3b of the housing encloses a bottom surface 4 with a central rotor axis opening and a medicament discharge opening 109.
  • the bottom surface can also be seen on a circular arc groove-shaped and coaxial with the rotor axis opening formed recess 7.
  • FIG. 4 shows a sectional view of the embodiment of the reservoir according to the invention.
  • the housing section 3e inclined toward the rotor 101 can be seen.
  • the bottom surface 4 adjoins the circular-cylindrical housing section 3b downwards, which in the embodiment shown is funnel-shaped towards the rotor axis opening.
  • the rotor 101 and the rotor axis 106 are arranged such that between the underside of the rotor and the top of the bottom surface 4, a gap 11 is formed through which impurity particles can move to the recess 7, wherein the recess is formed coaxially to the rotor axis opening in the funnel-shaped bottom surface 4 as a circumferential groove ,
  • a "section" through a channel is shown, on the right side a section through a web 108.
  • the receiving space 2 facing opening 103 and the bottom surface facing opening 104 can be seen wherein the opening 104 is aligned with an opening 109 in the bottom surface 4.
  • the dispensing position is shown, that is, in this position, a sporadic portion of medication via a correspondingly aligned channel of the opening 109 is supplied, via which it leaves the device for the automated dispensing of individual drug portions.
  • the web region covers over a section of the bottom surface 4 which is free in the region of the channels. Relative to any positions of the rotor 101, this results in the embodiment of the rotor shown, an annular area formed at the outer bottom surface 4, which is interrupted only by the opening 109. About this contact area 10 lying in the channels drug portions are moved (when singling) to the opening 109. Among other things, this movement can spew smallest drug particles from the individual portions of medication and contribute to the contamination of the reservoir. These contaminant particles would eventually be moved to the recess 7 and held in place by the constant vibration of the reservoir. In the embodiment shown, however, the bottom surface is funnel-shaped, whereby this formation of the bottom surface contributes to the contamination particles (due to gravity) reaching the depression 7.
  • a retaining means 105 On the left side there is further shown a retaining means 105, wherein a portion of this retaining means penetrates an opening 6 in the housing and engages in part in the channel aligned with the opening 109. In this way it is prevented that in the moment where an isolated portion of medication is dispensed through the opening 109, another portion of medication slips from above and also discharged. It follows that, in the event that two portions of medication should be dispensed, two turning steps of the rotor are necessary.
  • a vibration device 12 is arranged on the housing, with which impurity particles can be moved to the recess 7 by exposing the housing to vibrations.
  • FIG. 5 shows a further sectional view of the embodiment of the storage container according to the invention, wherein in this figure, the rotor is omitted.
  • the annular contact region 10 is illustrated on the bottom surface.
  • the opening 6 in the housing section 3b is also illustrated.
  • the rotor axis 106 is omitted, and it can be seen that a projection 9 is formed coaxially with the central rotor axis opening in the bottom surface 4, between the rotor axis opening and the recess 7. This projection prevents, should Pollution particles pass over the depression, they pass into the mechanically sensitive area at the rotor axis 106.
  • FIG. 7 shows the in FIG. 6 shown rotated by 180 °, and in this view, the channel engaging portion 105b of the retaining means 105 is shown.
  • the channel engaging portion 105b is either elastically deformed so as to be deformed by a land (eg, brush-like configuration of the engaging portion 105b), or the retaining means 105 includes an elastic portion such that the channel engaging portion 105b can be pressed out of the channel during a movement of the rotor.
  • the coaxial to the central opening in the bottom surface recess 7 is not completely annular, ie formed without interruption, but a part of the bottom surface 4 has no recess. This is due to the fact that in this area a cooperating with the rotor axis 106 stop mechanism 107 is formed, from the in FIG. 7 only a stop means 107b is shown, which engages in the region where usually the rotor axis is arranged.
  • FIG. 8 illustrates the aforementioned details in a detail enlargement.
  • the Figures 9A and 9B show detailed views of a part of the separating device and with this cooperating components.
  • the separating device comprises inter alia the rotor 101 with a plurality of channels 102, which are separated from one another by webs 108.
  • a plurality of cleaning means 110 are arranged, which help to move the resting on the bottom surface between the annular contact portion 10 and the recess 7 on the bottom surface 4 impurity particles to the recess, the orientation of the cleaning agent 110th depends on the direction of rotation of the rotor.
  • the Figure 9A further shows the stop mechanism 107 which cooperates with the rotor axis 106.
  • the stop mechanism 107 includes, inter alia, an at least partially elastic arm 107c, which in depressions of a toothing 106b formed in the rotor axis 106 (see FIG. 9B ) can intervene.
  • This stop mechanism is used to set the rotor at certain operating conditions, so that unintentional rotation of the rotor is avoided. This can prevent unintentionally dispensing a portion of medication.
  • the stop mechanism may lock the rotor when the reservoir is removed from the container receptacle.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Basic Packing Technique (AREA)
EP14175587.6A 2014-07-03 2014-07-03 Vorratsbehälter für eine Vorrichtung zum automatisierten Abgeben einzelner Medikamentenportionen Active EP2962956B1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES14175587.6T ES2609060T3 (es) 2014-07-03 2014-07-03 Recipiente de almacenamiento para un dispositivo de dispensación automatizada de porciones individuales de medicamento
EP14175587.6A EP2962956B1 (de) 2014-07-03 2014-07-03 Vorratsbehälter für eine Vorrichtung zum automatisierten Abgeben einzelner Medikamentenportionen
DK14175587.6T DK2962956T3 (en) 2014-07-03 2014-07-03 Storage container for a device for the automated dispensing of individual drug portions
PT141755876T PT2962956T (pt) 2014-07-03 2014-07-03 Recipiente de armazenamento para um dispositivo destinado à distribuição automática de doses individuais de medicamentos
PCT/EP2015/063463 WO2016000954A1 (de) 2014-07-03 2015-06-16 Vorratsbehälter für eine vorrichtung zum automatisierten abgeben einzelner medikamentenportionen
KR1020177000470A KR102423995B1 (ko) 2014-07-03 2015-06-16 의약품을 낱개로 자동 분배하는 장치의 저장 용기
CA2953650A CA2953650C (en) 2014-07-03 2015-06-16 Storage container for an apparatus for automated dispensing of individual medicament portions
AU2015283080A AU2015283080B2 (en) 2014-07-03 2015-06-16 Storage container for a device for automated dispensing of individual portions of medication
BR112016030617-1A BR112016030617B1 (pt) 2014-07-03 2015-06-16 Recipiente de armazenamento para um aparelho de distribuição automatizada de doses individuais de medicamentos
JP2017519799A JP2017523013A (ja) 2014-07-03 2015-06-16 個別薬部分を自動調合する装置のための保存容器
MX2016016772A MX356673B (es) 2014-07-03 2015-06-16 Recipiente de almacenamiento para un aparato para la dispensación automatizada de porciones de medicamento individuales.
JP2019237783A JP6937360B2 (ja) 2014-07-03 2019-12-27 個別薬部分を自動調合する装置のための保存容器

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14175587.6A EP2962956B1 (de) 2014-07-03 2014-07-03 Vorratsbehälter für eine Vorrichtung zum automatisierten Abgeben einzelner Medikamentenportionen

Publications (2)

Publication Number Publication Date
EP2962956A1 EP2962956A1 (de) 2016-01-06
EP2962956B1 true EP2962956B1 (de) 2016-11-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP14175587.6A Active EP2962956B1 (de) 2014-07-03 2014-07-03 Vorratsbehälter für eine Vorrichtung zum automatisierten Abgeben einzelner Medikamentenportionen

Country Status (11)

Country Link
EP (1) EP2962956B1 (es)
JP (2) JP2017523013A (es)
KR (1) KR102423995B1 (es)
AU (1) AU2015283080B2 (es)
BR (1) BR112016030617B1 (es)
CA (1) CA2953650C (es)
DK (1) DK2962956T3 (es)
ES (1) ES2609060T3 (es)
MX (1) MX356673B (es)
PT (1) PT2962956T (es)
WO (1) WO2016000954A1 (es)

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Publication number Priority date Publication date Assignee Title
EP3343521A1 (de) * 2016-12-29 2018-07-04 Becton Dickinson Rowa Germany GmbH Vorratsbehälter für eine vorrats- und abgabestation für arzneimittelportionen
EP4044136A1 (de) * 2017-02-03 2022-08-17 Becton Dickinson Rowa Germany GmbH Vorrats- und abgabestation für einen blisterautomaten
US10380824B2 (en) 2017-02-03 2019-08-13 Becton Dickinson Rowa Germany Gmbh Storage and dispensing station for blister packaging machine
EP3389022A1 (de) * 2017-04-11 2018-10-17 Becton Dickinson Rowa Germany GmbH Vorratsbehälter für eine vorrats- und abgabestation
JP7141004B2 (ja) 2019-02-14 2022-09-22 株式会社湯山製作所 錠剤払出システム、錠剤払出制御プログラム
US11352194B2 (en) 2020-06-16 2022-06-07 Becton Dickinson Rowa Germany Gmbh Storage container for a storage and dispensing station
EP3925590A1 (de) 2020-06-16 2021-12-22 Becton Dickinson Rowa Germany GmbH Vorratsbehälter für eine vorrats- und abgabestation
EP3991712A1 (de) * 2020-10-27 2022-05-04 Becton Dickinson Rowa Germany GmbH Vorratsbehälter für eine vorrats- und abgabestation und vorrats- und abgabestation
EP4067245A1 (de) * 2021-03-31 2022-10-05 Becton Dickinson Rowa Germany GmbH Vorrats- und abgabestation für einen blisterautomaten

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US4273254A (en) * 1979-01-23 1981-06-16 Brian Cuppleditch Device for containing and dispensing particles such as tablets
JP4298834B2 (ja) * 1999-01-14 2009-07-22 株式会社湯山製作所 錠剤フィーダ
US6234343B1 (en) * 1999-03-26 2001-05-22 Papp Enterprises, Llc Automated portable medication radial dispensing apparatus and method
JP2005059903A (ja) * 2003-08-13 2005-03-10 Yuyama Manufacturing Co Ltd 錠剤フィーダ
US7080755B2 (en) * 2004-09-13 2006-07-25 Michael Handfield Smart tray for dispensing medicaments
JP4473170B2 (ja) * 2005-04-27 2010-06-02 高園産業株式会社 錠剤カセッタ
JP4473174B2 (ja) * 2005-05-09 2010-06-02 高園産業株式会社 錠剤カセッタ
JP2007284087A (ja) * 2006-04-14 2007-11-01 Ckd Corp 錠剤供給用ボウルフィーダ
US20110192863A1 (en) * 2009-12-31 2011-08-11 Paul Leslie Barrass Ingestible Tablet Dispensers And Methods Of Dispensing Tablets
CA2701396A1 (en) 2010-04-22 2011-10-22 Leon Saltsov Medication dispensing and control unit
KR101183427B1 (ko) * 2011-01-20 2012-09-14 김광식 식품 또는 약품용 디스펜서

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Also Published As

Publication number Publication date
KR102423995B1 (ko) 2022-07-22
AU2015283080B2 (en) 2019-05-16
AU2015283080A1 (en) 2017-01-12
MX2016016772A (es) 2017-07-27
KR20170029493A (ko) 2017-03-15
WO2016000954A1 (de) 2016-01-07
JP6937360B2 (ja) 2021-09-22
PT2962956T (pt) 2016-12-30
EP2962956A1 (de) 2016-01-06
BR112016030617A2 (es) 2017-08-22
ES2609060T3 (es) 2017-04-18
BR112016030617B1 (pt) 2022-02-15
JP2017523013A (ja) 2017-08-17
CA2953650A1 (en) 2016-01-07
DK2962956T3 (en) 2017-01-23
MX356673B (es) 2018-06-08
CA2953650C (en) 2022-10-18
JP2020058854A (ja) 2020-04-16

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