EP2913063B1 - Therapeutic agent for use in treating amyotrophic lateral sclerosis - Google Patents
Therapeutic agent for use in treating amyotrophic lateral sclerosis Download PDFInfo
- Publication number
- EP2913063B1 EP2913063B1 EP13848825.9A EP13848825A EP2913063B1 EP 2913063 B1 EP2913063 B1 EP 2913063B1 EP 13848825 A EP13848825 A EP 13848825A EP 2913063 B1 EP2913063 B1 EP 2913063B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- amino acid
- therapeutic agent
- ghrelin
- acid residue
- growth hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
Definitions
- the present invention relates to a therapeutic agent for amyotrophic lateral sclerosis comprising a growth hormone secretagogue receptor agonist as an active ingredient, wherein the growth hormone secretagogue receptor agonist is ghrelin, GHRP-6, or anamorelin.
- amino acids with protective groups are condensed by a liquid-phase method and/or a solid-phase method to extend a peptide chain. All of the protective groups are removed with an acid.
- the obtained crude product is purified by a purification method known in the art to obtain the peptide compound for use according to the present invention.
- amino acids with protective groups are condensed by a liquid-phase method and/or a solid-phase method to extend a peptide chain. All of the protective groups are removed with an acid.
- the obtained crude product can be purified by the above purification method to obtain the ghrelin or its derivative for use according to the disclosure herein.
- the side chain of the amino acid located at the position of interest can be selectively acylated with an acylating enzyme or acyltransferase.
- unresponsive in relation to an existing therapeutic agent for amyotrophic lateral sclerosis (therapeutic agent for ALS) refers to a state where the therapeutic effect of the existing therapeutic agent for ALS previously or currently used is not seen or a state where the effect is not maintained, i.e., a state where the pathological progression is not suppressed by the administration of the existing therapeutic agent for ALS.
- the unresponsiveness to treatment with the existing therapeutic agent for ALS is evaluated by the examination of one or more clinical evaluation indexes in ALSFRS-R mentioned above.
- the unresponsiveness to the existing therapeutic agent for ALS can be determined by a clinician skilled in the treatment of ALS.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Marine Sciences & Fisheries (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012234300 | 2012-10-24 | ||
| PCT/JP2013/078743 WO2014065341A1 (ja) | 2012-10-24 | 2013-10-23 | 筋萎縮性側索硬化症治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2913063A1 EP2913063A1 (en) | 2015-09-02 |
| EP2913063A4 EP2913063A4 (en) | 2016-07-20 |
| EP2913063B1 true EP2913063B1 (en) | 2019-09-11 |
Family
ID=50544716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP13848825.9A Active EP2913063B1 (en) | 2012-10-24 | 2013-10-23 | Therapeutic agent for use in treating amyotrophic lateral sclerosis |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150265680A1 (ru) |
| EP (1) | EP2913063B1 (ru) |
| JP (1) | JP6262661B2 (ru) |
| KR (3) | KR20200108494A (ru) |
| CN (2) | CN104853778A (ru) |
| AU (1) | AU2013335678B2 (ru) |
| BR (1) | BR112015009107A2 (ru) |
| CA (1) | CA2889499C (ru) |
| HK (1) | HK1214152A1 (ru) |
| IN (1) | IN2015DN04172A (ru) |
| RU (1) | RU2655811C2 (ru) |
| WO (1) | WO2014065341A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201703884PA (en) | 2014-11-12 | 2017-06-29 | Lyric Pharmaceuticals Inc | Treatment of enteral feeding intolerance |
| WO2017083882A1 (en) * | 2015-11-11 | 2017-05-18 | Lyric Pharmaceuticals Inc. | Treatment of enteral feeding intolerance and other conditions using ulimorelin analogs |
| BR112021010660A2 (pt) * | 2018-12-06 | 2021-08-24 | Biogen Ma Inc. | Proteína de neurofilamento para guiar intervenção terapêutica sobre esclerose lateral amiotrófica |
| US11969416B1 (en) | 2022-11-03 | 2024-04-30 | Lumos Pharma, Inc. | Compactable oral formulations of ibutamoren |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668254A (en) | 1990-05-11 | 1997-09-16 | Romano Deghenghi | D-2-alkyl-tryptophan and peptides containing same |
| US5663146A (en) | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| US5578593A (en) | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
| TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| ES2237135T3 (es) | 1998-08-20 | 2005-07-16 | Sumitomo Pharmaceuticals Company, Limited | Derivados de oxindol como liberadores de la hormona del crecimiento. |
| DK1795598T3 (da) | 1999-07-23 | 2010-02-01 | Kenji Kangawa | Hidtil ukendte peptider |
| UA73530C2 (ru) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Соединение со свойствами освобождения гормона роста |
| ATE304373T1 (de) | 1999-12-28 | 2005-09-15 | Kaken Pharma Co Ltd | Nervenschutzmittel |
| DE60128494T2 (de) | 2000-06-13 | 2008-01-17 | Zentaris Gmbh | Verbindungen zur Stimulation der Sekretion von Wachstumshormonen |
| EP1493747B1 (en) | 2002-04-11 | 2012-12-19 | Daiichi Sankyo Company, Limited | Process for producing modified peptide |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| JP2005239712A (ja) | 2004-01-30 | 2005-09-08 | Kaken Pharmaceut Co Ltd | 神経突起伸展剤 |
| WO2006079077A2 (en) * | 2005-01-20 | 2006-07-27 | Acadia Pharmaceuticals Inc. | Use of diltiazem or analogs thereof as modulators of ghrelin receptor |
| US7829589B2 (en) | 2005-06-10 | 2010-11-09 | Elixir Pharmaceuticals, Inc. | Sulfonamide compounds and uses thereof |
| CA2625341A1 (en) * | 2005-10-18 | 2007-04-26 | Ono Pharmaceutical Co., Ltd. | Pharmaceutical for protection of motor nerve in patient with amyotrophic lateral sclerosis |
| PL2029742T3 (pl) | 2006-06-07 | 2017-08-31 | Genzyme Corporation | Terapia genowa w stwardnieniu zanikowym bocznym i innych zaburzeniach rdzenia kręgowego |
| JP2008127377A (ja) | 2006-11-24 | 2008-06-05 | Jichi Medical Univ | Ｇｈｓ−ｒ作動薬を含有してなるメタボリックシンドローム又は高血圧症の予防・治療剤。 |
| KR100946084B1 (ko) | 2008-03-27 | 2010-03-10 | 주식회사 하이닉스반도체 | 반도체 소자의 수직형 트랜지스터 및 그 형성방법 |
| AU2009231394B2 (en) * | 2008-04-03 | 2013-09-05 | F. Hoffmann-La Roche Ag | Use of PEGylated IGF-I variants for the treatment of neuromuscular disorders |
-
2013
- 2013-10-23 KR KR1020207026038A patent/KR20200108494A/ko not_active Application Discontinuation
- 2013-10-23 US US14/437,459 patent/US20150265680A1/en not_active Abandoned
- 2013-10-23 KR KR1020227012378A patent/KR102499918B1/ko active IP Right Grant
- 2013-10-23 WO PCT/JP2013/078743 patent/WO2014065341A1/ja active Application Filing
- 2013-10-23 IN IN4172DEN2015 patent/IN2015DN04172A/en unknown
- 2013-10-23 RU RU2015119472A patent/RU2655811C2/ru active
- 2013-10-23 CN CN201380066625.1A patent/CN104853778A/zh active Pending
- 2013-10-23 JP JP2014543332A patent/JP6262661B2/ja active Active
- 2013-10-23 BR BR112015009107A patent/BR112015009107A2/pt not_active Application Discontinuation
- 2013-10-23 AU AU2013335678A patent/AU2013335678B2/en active Active
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- 2013-10-23 CA CA2889499A patent/CA2889499C/en active Active
- 2013-10-23 CN CN201910808882.7A patent/CN110354265A/zh active Pending
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2016
- 2016-02-25 HK HK16102170.0A patent/HK1214152A1/zh unknown
Non-Patent Citations (1)
| Title |
|---|
| None * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2014065341A1 (ja) | 2016-09-08 |
| JP6262661B2 (ja) | 2018-01-17 |
| US20150265680A1 (en) | 2015-09-24 |
| RU2655811C2 (ru) | 2018-05-29 |
| CA2889499A1 (en) | 2014-05-01 |
| BR112015009107A2 (pt) | 2017-11-14 |
| IN2015DN04172A (ru) | 2015-10-16 |
| EP2913063A4 (en) | 2016-07-20 |
| KR20220051418A (ko) | 2022-04-26 |
| EP2913063A1 (en) | 2015-09-02 |
| RU2015119472A (ru) | 2016-12-20 |
| CN104853778A (zh) | 2015-08-19 |
| KR102499918B1 (ko) | 2023-02-14 |
| AU2013335678A1 (en) | 2015-05-21 |
| CN110354265A (zh) | 2019-10-22 |
| KR20150070180A (ko) | 2015-06-24 |
| AU2013335678B2 (en) | 2017-10-26 |
| WO2014065341A1 (ja) | 2014-05-01 |
| CA2889499C (en) | 2019-09-10 |
| HK1214152A1 (zh) | 2016-07-22 |
| KR20200108494A (ko) | 2020-09-18 |
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