EP2909166A4 - Prozesse zur herstellung von agomelatin mithilfe neuartiger zwischenstoffe - Google Patents
Prozesse zur herstellung von agomelatin mithilfe neuartiger zwischenstoffeInfo
- Publication number
- EP2909166A4 EP2909166A4 EP12887041.7A EP12887041A EP2909166A4 EP 2909166 A4 EP2909166 A4 EP 2909166A4 EP 12887041 A EP12887041 A EP 12887041A EP 2909166 A4 EP2909166 A4 EP 2909166A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- agomelatine
- processes
- preparation
- novel intermediates
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/26—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2012/000694 WO2014064706A1 (en) | 2012-10-22 | 2012-10-22 | Processes for the preparation of agomelatine using novel intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2909166A1 EP2909166A1 (de) | 2015-08-26 |
EP2909166A4 true EP2909166A4 (de) | 2016-10-26 |
Family
ID=50544131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12887041.7A Withdrawn EP2909166A4 (de) | 2012-10-22 | 2012-10-22 | Prozesse zur herstellung von agomelatin mithilfe neuartiger zwischenstoffe |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2909166A4 (de) |
AR (1) | AR093245A1 (de) |
WO (1) | WO2014064706A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016046833A2 (en) * | 2014-09-24 | 2016-03-31 | Symed Labs Limited | Improved processes for the preparation of agomelatine using novel intermediates |
CN107353229B (zh) * | 2017-08-08 | 2019-04-30 | 许昌恒生制药有限公司 | 一种阿戈美拉汀中间体的制备方法 |
CN113527139A (zh) * | 2020-04-17 | 2021-10-22 | 上海法默生物科技有限公司 | 合成7-甲氧基-1-萘乙腈的方法及中间体 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225442A (en) * | 1990-02-27 | 1993-07-06 | Adir Et Compagnie | Compounds having a naphthalene structure |
US5668180A (en) * | 1995-05-31 | 1997-09-16 | Adir Et Compagnie | Alkoxyaryl compounds |
US20050182276A1 (en) * | 2004-02-13 | 2005-08-18 | Jean-Claude Souvie | Process for the synthesis and crystalline form of agomelatine |
US20100004340A1 (en) * | 2007-05-01 | 2010-01-07 | Concert Pharmaceuticals, Inc. | Naphthyl(ethyl) acetamides |
WO2012093402A1 (en) * | 2011-01-04 | 2012-07-12 | Symed Labs Limited | Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071875A (en) * | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
FR2680507B1 (fr) * | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2689124A1 (fr) * | 1992-03-27 | 1993-10-01 | Adir | Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
2012
- 2012-10-22 EP EP12887041.7A patent/EP2909166A4/de not_active Withdrawn
- 2012-10-22 WO PCT/IN2012/000694 patent/WO2014064706A1/en active Application Filing
-
2013
- 2013-10-22 AR ARP130103817A patent/AR093245A1/es unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225442A (en) * | 1990-02-27 | 1993-07-06 | Adir Et Compagnie | Compounds having a naphthalene structure |
US5668180A (en) * | 1995-05-31 | 1997-09-16 | Adir Et Compagnie | Alkoxyaryl compounds |
US20050182276A1 (en) * | 2004-02-13 | 2005-08-18 | Jean-Claude Souvie | Process for the synthesis and crystalline form of agomelatine |
US20100004340A1 (en) * | 2007-05-01 | 2010-01-07 | Concert Pharmaceuticals, Inc. | Naphthyl(ethyl) acetamides |
WO2012093402A1 (en) * | 2011-01-04 | 2012-07-12 | Symed Labs Limited | Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide |
Non-Patent Citations (2)
Title |
---|
DEPREUX P ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL NAPHTHALENIC AND BIOISOSTERIC AMIDIC DERIVATIVES AS MELATONIN RECEPTOR LIGANDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37, no. 20, 30 September 1994 (1994-09-30), pages 3231 - 3239, XP002016146, ISSN: 0022-2623, DOI: 10.1021/JM00046A006 * |
See also references of WO2014064706A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2014064706A1 (en) | 2014-05-01 |
AR093245A1 (es) | 2015-05-27 |
EP2909166A1 (de) | 2015-08-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20150520 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 231/02 20060101ALI20160518BHEP Ipc: C07C 215/26 20060101ALI20160518BHEP Ipc: C07C 213/10 20060101ALI20160518BHEP Ipc: C07C 233/22 20060101ALI20160518BHEP Ipc: C07C 255/36 20060101ALI20160518BHEP Ipc: C07C 253/30 20060101ALI20160518BHEP Ipc: C07C 213/02 20060101AFI20160518BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20160921 |
|
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20160922 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 231/02 20060101ALI20160916BHEP Ipc: C07C 213/02 20060101AFI20160916BHEP Ipc: C07C 233/22 20060101ALI20160916BHEP Ipc: C07C 255/36 20060101ALI20160916BHEP Ipc: C07C 213/10 20060101ALI20160916BHEP Ipc: C07C 215/26 20060101ALI20160916BHEP Ipc: C07C 253/30 20060101ALI20160916BHEP |