EP2909166A4 - PROCESS FOR THE PREPARATION OF AGOMALATIN USING NEW INTERMEDIATES - Google Patents

PROCESS FOR THE PREPARATION OF AGOMALATIN USING NEW INTERMEDIATES

Info

Publication number
EP2909166A4
EP2909166A4 EP12887041.7A EP12887041A EP2909166A4 EP 2909166 A4 EP2909166 A4 EP 2909166A4 EP 12887041 A EP12887041 A EP 12887041A EP 2909166 A4 EP2909166 A4 EP 2909166A4
Authority
EP
European Patent Office
Prior art keywords
agomalatin
preparation
new intermediates
intermediates
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12887041.7A
Other languages
German (de)
French (fr)
Other versions
EP2909166A1 (en
Inventor
Rao Dodda Mohan
Reddy Ambati Anna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symed Labs Ltd
Original Assignee
Symed Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symed Labs Ltd filed Critical Symed Labs Ltd
Publication of EP2909166A1 publication Critical patent/EP2909166A1/en
Publication of EP2909166A4 publication Critical patent/EP2909166A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/26—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP12887041.7A 2012-10-22 2012-10-22 PROCESS FOR THE PREPARATION OF AGOMALATIN USING NEW INTERMEDIATES Withdrawn EP2909166A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2012/000694 WO2014064706A1 (en) 2012-10-22 2012-10-22 Processes for the preparation of agomelatine using novel intermediates

Publications (2)

Publication Number Publication Date
EP2909166A1 EP2909166A1 (en) 2015-08-26
EP2909166A4 true EP2909166A4 (en) 2016-10-26

Family

ID=50544131

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12887041.7A Withdrawn EP2909166A4 (en) 2012-10-22 2012-10-22 PROCESS FOR THE PREPARATION OF AGOMALATIN USING NEW INTERMEDIATES

Country Status (3)

Country Link
EP (1) EP2909166A4 (en)
AR (1) AR093245A1 (en)
WO (1) WO2014064706A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016046833A2 (en) * 2014-09-24 2016-03-31 Symed Labs Limited Improved processes for the preparation of agomelatine using novel intermediates
CN107353229B (en) * 2017-08-08 2019-04-30 许昌恒生制药有限公司 A kind of preparation method of agomelatine intermediate body
CN113527139A (en) * 2020-04-17 2021-10-22 上海法默生物科技有限公司 Method for synthesizing 7-methoxy-1-naphthylacetonitrile and intermediate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225442A (en) * 1990-02-27 1993-07-06 Adir Et Compagnie Compounds having a naphthalene structure
US5668180A (en) * 1995-05-31 1997-09-16 Adir Et Compagnie Alkoxyaryl compounds
US20050182276A1 (en) * 2004-02-13 2005-08-18 Jean-Claude Souvie Process for the synthesis and crystalline form of agomelatine
US20100004340A1 (en) * 2007-05-01 2010-01-07 Concert Pharmaceuticals, Inc. Naphthyl(ethyl) acetamides
WO2012093402A1 (en) * 2011-01-04 2012-07-12 Symed Labs Limited Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2680507B1 (en) * 1991-08-23 1993-10-08 Adir Cie NOVEL NAPHTYLETHYLUREES AND NAPHTYLETHYLTHIOURES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2689124A1 (en) * 1992-03-27 1993-10-01 Adir Novel naphthylalkylamines, process for their preparation and pharmaceutical compositions containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225442A (en) * 1990-02-27 1993-07-06 Adir Et Compagnie Compounds having a naphthalene structure
US5668180A (en) * 1995-05-31 1997-09-16 Adir Et Compagnie Alkoxyaryl compounds
US20050182276A1 (en) * 2004-02-13 2005-08-18 Jean-Claude Souvie Process for the synthesis and crystalline form of agomelatine
US20100004340A1 (en) * 2007-05-01 2010-01-07 Concert Pharmaceuticals, Inc. Naphthyl(ethyl) acetamides
WO2012093402A1 (en) * 2011-01-04 2012-07-12 Symed Labs Limited Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEPREUX P ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL NAPHTHALENIC AND BIOISOSTERIC AMIDIC DERIVATIVES AS MELATONIN RECEPTOR LIGANDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37, no. 20, 30 September 1994 (1994-09-30), pages 3231 - 3239, XP002016146, ISSN: 0022-2623, DOI: 10.1021/JM00046A006 *
See also references of WO2014064706A1 *

Also Published As

Publication number Publication date
AR093245A1 (en) 2015-05-27
EP2909166A1 (en) 2015-08-26
WO2014064706A1 (en) 2014-05-01

Similar Documents

Publication Publication Date Title
EP2780307A4 (en) PROCESS FOR THE PREPARATION OF HYDROFLUOROOLEFINS
EP2831082A4 (en) SYNTHESIS PROCESS FOR THE PREPARATION OF MACROCYCLIC C1-KEY ANALOGS OF HALICHONDRIN B AND INTERMEDIATES THEREFOR
EP2939260A4 (en) METHOD FOR PREPARING SAMPLES FOR IMAGING
EP2846901A4 (en) METHOD FOR ADJUSTING THE SIZE OF NANOPORES IN THE SOLID STATE
EP2907836A4 (en) PROCESS FOR THE CONTINUOUS PRODUCTION OF POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER
FR2991320B1 (en) PROCESS FOR THE PREPARATION OF METHYL AMINES
EP2852967A4 (en) PREPARATION OF LAMELLES FOR MET OBSERVATION
EP2552873A4 (en) PROCESS FOR THE PRODUCTION OF HEXAFLUORO-2-BUTENE
EP2603611A4 (en) METHOD FOR REMOVAL OF RETROVIRUS
EP2717857A4 (en) PROCESS FOR THE SYNTHESIS OF PORPHYRINE-PHOSPHOLIPID CONJUGATES
EP2938616A4 (en) PROCESS FOR THE PREPARATION OF TOFACITINIB AND INTERMEDIATES
EP2894147A4 (en) CLEAN PROCESS FOR THE PREPARATION OF D, L-METHIONINE
EP2687588A4 (en) PROCESS FOR THE PREPARATION OF BIODIESEL
EP2683306A4 (en) SLEEVE FOR REMOVABLE LANCETTE OF AUTOPIQUEUR
EP2550269A4 (en) PROCESS AND INTERMEDIATES FOR THE PREPARATION OF LAPATINIB
EP2479304A4 (en) PROCESS FOR THE PREPARATION OF ALUMINUM-ZIRCONIUM-TITANIUM-CARBON INTERMEDIATE ALLOY
EP2663288A4 (en) PROCESS FOR THE PREPARATION OF VESICLES AND FORMULATIONS PRODUCED THEREFROM
EP2922820A4 (en) PROCESS FOR THE PREPARATION OF CRYSTALLINE SORAFENIB TOSYLATE
EP2951191A4 (en) PROCESS FOR THE PREPARATION OF OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS
EP2940196A4 (en) PROCESS FOR THE PRODUCTION OF SiC MONOCRYSTAL OF TYPE n
EP2874980A4 (en) IMPROVED PROCESS FOR THE PREPARATION OF 2,3-DIHYDROXYBENZONITRILE
EP2521712A4 (en) PROCESS FOR THE PREPARATION OF PERFLUOROALKYLSULFENYL CHLORIDE
EP2881196A4 (en) PROCESS FOR CONTINUOUS CASTING OF STEEL
EP2831036A4 (en) PROCESS FOR THE PREPARATION OF ALKYL ESTERS OF FLUOROLEUCIN
EP2545941A4 (en) METHOD FOR THE PROLIFERATION OF CARDIOMYOCYTES USING A MICRO-RNA

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20150520

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 231/02 20060101ALI20160518BHEP

Ipc: C07C 215/26 20060101ALI20160518BHEP

Ipc: C07C 213/10 20060101ALI20160518BHEP

Ipc: C07C 233/22 20060101ALI20160518BHEP

Ipc: C07C 255/36 20060101ALI20160518BHEP

Ipc: C07C 253/30 20060101ALI20160518BHEP

Ipc: C07C 213/02 20060101AFI20160518BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20160921

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20160922

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 231/02 20060101ALI20160916BHEP

Ipc: C07C 213/02 20060101AFI20160916BHEP

Ipc: C07C 233/22 20060101ALI20160916BHEP

Ipc: C07C 255/36 20060101ALI20160916BHEP

Ipc: C07C 213/10 20060101ALI20160916BHEP

Ipc: C07C 215/26 20060101ALI20160916BHEP

Ipc: C07C 253/30 20060101ALI20160916BHEP