EP2909166A4 - Processes for the preparation of agomelatine using novel intermediates - Google Patents

Processes for the preparation of agomelatine using novel intermediates

Info

Publication number
EP2909166A4
EP2909166A4 EP12887041.7A EP12887041A EP2909166A4 EP 2909166 A4 EP2909166 A4 EP 2909166A4 EP 12887041 A EP12887041 A EP 12887041A EP 2909166 A4 EP2909166 A4 EP 2909166A4
Authority
EP
European Patent Office
Prior art keywords
agomelatine
processes
preparation
novel intermediates
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12887041.7A
Other languages
German (de)
French (fr)
Other versions
EP2909166A1 (en
Inventor
Rao Dodda Mohan
Reddy Ambati Anna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symed Labs Ltd
Original Assignee
Symed Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symed Labs Ltd filed Critical Symed Labs Ltd
Publication of EP2909166A1 publication Critical patent/EP2909166A1/en
Publication of EP2909166A4 publication Critical patent/EP2909166A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/26—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
EP12887041.7A 2012-10-22 2012-10-22 Processes for the preparation of agomelatine using novel intermediates Withdrawn EP2909166A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2012/000694 WO2014064706A1 (en) 2012-10-22 2012-10-22 Processes for the preparation of agomelatine using novel intermediates

Publications (2)

Publication Number Publication Date
EP2909166A1 EP2909166A1 (en) 2015-08-26
EP2909166A4 true EP2909166A4 (en) 2016-10-26

Family

ID=50544131

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12887041.7A Withdrawn EP2909166A4 (en) 2012-10-22 2012-10-22 Processes for the preparation of agomelatine using novel intermediates

Country Status (3)

Country Link
EP (1) EP2909166A4 (en)
AR (1) AR093245A1 (en)
WO (1) WO2014064706A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016046833A2 (en) * 2014-09-24 2016-03-31 Symed Labs Limited Improved processes for the preparation of agomelatine using novel intermediates
CN107353229B (en) * 2017-08-08 2019-04-30 许昌恒生制药有限公司 A kind of preparation method of agomelatine intermediate body
CN113527139A (en) * 2020-04-17 2021-10-22 上海法默生物科技有限公司 Method for synthesizing 7-methoxy-1-naphthylacetonitrile and intermediate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225442A (en) * 1990-02-27 1993-07-06 Adir Et Compagnie Compounds having a naphthalene structure
US5668180A (en) * 1995-05-31 1997-09-16 Adir Et Compagnie Alkoxyaryl compounds
US20050182276A1 (en) * 2004-02-13 2005-08-18 Jean-Claude Souvie Process for the synthesis and crystalline form of agomelatine
US20100004340A1 (en) * 2007-05-01 2010-01-07 Concert Pharmaceuticals, Inc. Naphthyl(ethyl) acetamides
WO2012093402A1 (en) * 2011-01-04 2012-07-12 Symed Labs Limited Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2680507B1 (en) * 1991-08-23 1993-10-08 Adir Cie NOVEL NAPHTYLETHYLUREES AND NAPHTYLETHYLTHIOURES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2689124A1 (en) * 1992-03-27 1993-10-01 Adir Novel naphthylalkylamines, process for their preparation and pharmaceutical compositions containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225442A (en) * 1990-02-27 1993-07-06 Adir Et Compagnie Compounds having a naphthalene structure
US5668180A (en) * 1995-05-31 1997-09-16 Adir Et Compagnie Alkoxyaryl compounds
US20050182276A1 (en) * 2004-02-13 2005-08-18 Jean-Claude Souvie Process for the synthesis and crystalline form of agomelatine
US20100004340A1 (en) * 2007-05-01 2010-01-07 Concert Pharmaceuticals, Inc. Naphthyl(ethyl) acetamides
WO2012093402A1 (en) * 2011-01-04 2012-07-12 Symed Labs Limited Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEPREUX P ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL NAPHTHALENIC AND BIOISOSTERIC AMIDIC DERIVATIVES AS MELATONIN RECEPTOR LIGANDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37, no. 20, 30 September 1994 (1994-09-30), pages 3231 - 3239, XP002016146, ISSN: 0022-2623, DOI: 10.1021/JM00046A006 *
See also references of WO2014064706A1 *

Also Published As

Publication number Publication date
WO2014064706A1 (en) 2014-05-01
EP2909166A1 (en) 2015-08-26
AR093245A1 (en) 2015-05-27

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