EP2872500A4 - Procédé perfectionné pour la préparation d'etexilate mésylate de dabigatran et de ses intermédiaires - Google Patents

Procédé perfectionné pour la préparation d'etexilate mésylate de dabigatran et de ses intermédiaires

Info

Publication number
EP2872500A4
EP2872500A4 EP13816563.4A EP13816563A EP2872500A4 EP 2872500 A4 EP2872500 A4 EP 2872500A4 EP 13816563 A EP13816563 A EP 13816563A EP 2872500 A4 EP2872500 A4 EP 2872500A4
Authority
EP
European Patent Office
Prior art keywords
intermediates
preparation
improved process
dabigatran etexilate
etexilate mesylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13816563.4A
Other languages
German (de)
English (en)
Other versions
EP2872500A2 (fr
Inventor
Ravi Ponnaiah
Praveen Kumar Neela
Guruswamy Batthini
Narayana B Veera
Telegareddy Venkata Narasimha Rao
Ravana K Babu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2872500A2 publication Critical patent/EP2872500A2/fr
Publication of EP2872500A4 publication Critical patent/EP2872500A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
EP13816563.4A 2012-07-12 2013-07-05 Procédé perfectionné pour la préparation d'etexilate mésylate de dabigatran et de ses intermédiaires Ceased EP2872500A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2838CH2012 2012-07-12
IN4298CH2012 2012-10-15
PCT/IN2013/000413 WO2014009966A2 (fr) 2012-07-12 2013-07-05 Procédé perfectionné pour la préparation d'etexilate mésylate de dabigatran et de ses intermédiaires

Publications (2)

Publication Number Publication Date
EP2872500A2 EP2872500A2 (fr) 2015-05-20
EP2872500A4 true EP2872500A4 (fr) 2016-03-30

Family

ID=49916616

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13816563.4A Ceased EP2872500A4 (fr) 2012-07-12 2013-07-05 Procédé perfectionné pour la préparation d'etexilate mésylate de dabigatran et de ses intermédiaires

Country Status (2)

Country Link
EP (1) EP2872500A4 (fr)
WO (1) WO2014009966A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104892574A (zh) * 2014-03-04 2015-09-09 浙江海正药业股份有限公司 达比加群酯甲磺酸盐的晶型及其制备方法和用途
WO2015137680A1 (fr) * 2014-03-10 2015-09-17 동아에스티 주식회사 Composition pharmaceutique de traitement ou de prévention d'un accident vasculaire cérébral et de l'embolie systémique
CN108947966A (zh) * 2014-04-04 2018-12-07 江苏天士力帝益药业有限公司 达比加群酯甲磺酸盐新晶型及其制备方法
CN103951654B (zh) * 2014-05-13 2016-08-24 南京生命能科技开发有限公司 甲磺酸达比加群酯的晶体v及其制备方法
CN103965164A (zh) * 2014-05-13 2014-08-06 南京生命能科技开发有限公司 甲磺酸达比加群酯的晶体ⅵ及其制备方法
CN105348263B (zh) * 2015-12-15 2018-03-23 乐普药业股份有限公司 一种达比加群酯中间体的制备方法
CN108727334B (zh) * 2018-07-12 2020-10-30 江西国药有限责任公司 一种甲磺酸达比加群酯的生产工艺
WO2022006007A1 (fr) * 2020-06-29 2022-01-06 The General Hospital Corporation Procédés d'imagerie d'infections bactériennes
CN116041724B (zh) * 2023-02-23 2024-03-01 天津工业大学 一种多孔手性金属-有机框架材料及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100509799C (zh) * 2005-12-16 2009-07-08 复旦大学 一种合成非手性，非肽类的抗凝血酶抑制剂的方法
DE102005061623A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
DE102006054005A1 (de) * 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
WO2012027543A1 (fr) * 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Formes solides de dabigatran étexilate et de dabigatran étexilate mésylate et leurs méthodes de préparation
EP2522662A1 (fr) * 2011-05-11 2012-11-14 Medichem, S.A. Dabigatran etexilate et substances, procédés et compositions correspondants, et utilisation des substances en tant que standards de référence et marqueurs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAUEL N H ET AL: "STRUCTURE-BASED DESIGN OF NOVEL POTENT NONPEPTIDE THROMBIN INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 9, 1 January 2002 (2002-01-01), pages 1757 - 1766, XP001098844, ISSN: 0022-2623, DOI: 10.1021/JM0109513 *

Also Published As

Publication number Publication date
EP2872500A2 (fr) 2015-05-20
WO2014009966A3 (fr) 2014-03-06
WO2014009966A2 (fr) 2014-01-16

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