EP2872500A4 - Verbessertes verfahren zur herstellung von dabigatranetexilatmesylat und zwischenprodukten davon - Google Patents

Verbessertes verfahren zur herstellung von dabigatranetexilatmesylat und zwischenprodukten davon

Info

Publication number
EP2872500A4
EP2872500A4 EP13816563.4A EP13816563A EP2872500A4 EP 2872500 A4 EP2872500 A4 EP 2872500A4 EP 13816563 A EP13816563 A EP 13816563A EP 2872500 A4 EP2872500 A4 EP 2872500A4
Authority
EP
European Patent Office
Prior art keywords
etexilate
dabigatran
mesylate
intermediates
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13816563.4A
Other languages
English (en)
French (fr)
Other versions
EP2872500A2 (de
Inventor
Ravi Ponnaiah
Praveen Kumar Neela
Guruswamy Batthini
Narayana B Veera
Telegareddy Venkata Narasimha Rao
Ravana K Babu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2872500A2 publication Critical patent/EP2872500A2/de
Publication of EP2872500A4 publication Critical patent/EP2872500A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EP13816563.4A 2012-07-12 2013-07-05 Verbessertes verfahren zur herstellung von dabigatranetexilatmesylat und zwischenprodukten davon Ceased EP2872500A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2838CH2012 2012-07-12
IN4298CH2012 2012-10-15
PCT/IN2013/000413 WO2014009966A2 (en) 2012-07-12 2013-07-05 An improved process for the preparation of dabigatran etexilate mesylate and its intermediates thereof

Publications (2)

Publication Number Publication Date
EP2872500A2 EP2872500A2 (de) 2015-05-20
EP2872500A4 true EP2872500A4 (de) 2016-03-30

Family

ID=49916616

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13816563.4A Ceased EP2872500A4 (de) 2012-07-12 2013-07-05 Verbessertes verfahren zur herstellung von dabigatranetexilatmesylat und zwischenprodukten davon

Country Status (2)

Country Link
EP (1) EP2872500A4 (de)
WO (1) WO2014009966A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104892574A (zh) * 2014-03-04 2015-09-09 浙江海正药业股份有限公司 达比加群酯甲磺酸盐的晶型及其制备方法和用途
WO2015137680A1 (ko) * 2014-03-10 2015-09-17 동아에스티 주식회사 뇌졸중 및 전신색전증 치료 또는 예방용 약학적 조성물
CN104974137A (zh) * 2014-04-04 2015-10-14 江苏天士力帝益药业有限公司 达比加群酯甲磺酸盐新晶型及其制备方法
CN103951654B (zh) * 2014-05-13 2016-08-24 南京生命能科技开发有限公司 甲磺酸达比加群酯的晶体v及其制备方法
CN103965164A (zh) * 2014-05-13 2014-08-06 南京生命能科技开发有限公司 甲磺酸达比加群酯的晶体ⅵ及其制备方法
CN105348263B (zh) * 2015-12-15 2018-03-23 乐普药业股份有限公司 一种达比加群酯中间体的制备方法
CN108727334B (zh) * 2018-07-12 2020-10-30 江西国药有限责任公司 一种甲磺酸达比加群酯的生产工艺
WO2022006007A1 (en) * 2020-06-29 2022-01-06 The General Hospital Corporation Methods for imaging bacterial infections
CN116041724B (zh) * 2023-02-23 2024-03-01 天津工业大学 一种多孔手性金属-有机框架材料及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861596A (zh) * 2005-12-16 2006-11-15 复旦大学 一种合成非手性，非肽类的抗凝血酶抑制剂的方法
WO2007071742A1 (en) * 2005-12-21 2007-06-28 Boehringer Ingelheim International Gmbh Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof
WO2012004396A2 (en) * 2010-07-09 2012-01-12 Esteve Química, S.A. Process of preparing a thrombin specific inhibitor
WO2012027543A1 (en) * 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
EP2522662A1 (de) * 2011-05-11 2012-11-14 Medichem, S.A. Dabigatranetexilat und zugehörige Substanzen, Verfahren und Zusammensetzungen sowie Verwendung der Substanzen als Referenzstandards und Marker

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054005A1 (de) * 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861596A (zh) * 2005-12-16 2006-11-15 复旦大学 一种合成非手性，非肽类的抗凝血酶抑制剂的方法
WO2007071742A1 (en) * 2005-12-21 2007-06-28 Boehringer Ingelheim International Gmbh Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof
WO2012004396A2 (en) * 2010-07-09 2012-01-12 Esteve Química, S.A. Process of preparing a thrombin specific inhibitor
WO2012027543A1 (en) * 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
EP2522662A1 (de) * 2011-05-11 2012-11-14 Medichem, S.A. Dabigatranetexilat und zugehörige Substanzen, Verfahren und Zusammensetzungen sowie Verwendung der Substanzen als Referenzstandards und Marker

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHENG ET AL: "Synthesis of dabigatran etexilate mesylate", ZHONGGUO XIN YAO ZAZHI - CHINESE NEW DRUGS JOU, GAI-KAN BIANJIBU, BEIJING, CN, vol. 21, no. 1, 1 January 2012 (2012-01-01), pages 88 - 91, XP008175968, ISSN: 1003-3734 *
HAUEL N H ET AL: "STRUCTURE-BASED DESIGN OF NOVEL POTENT NONPEPTIDE THROMBIN INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 9, 1 January 2002 (2002-01-01), pages 1757 - 1766, XP001098844, ISSN: 0022-2623, DOI: 10.1021/JM0109513 *
ZHU ET AL: "Improved synthesis of dabigatran etexilate", ZHONGGUO YAOWU HUAXUE ZAZHI - CHINESE JOURNAL OF MEDICINAL CHEMIS, GAI-KAI BIANJIBU, SHENYANG, CN, vol. 22, no. 3, 1 June 2012 (2012-06-01), pages 204 - 208, XP008175937, ISSN: 1005-0108 *

Also Published As

Publication number Publication date
WO2014009966A3 (en) 2014-03-06
WO2014009966A2 (en) 2014-01-16
EP2872500A2 (de) 2015-05-20

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