EP2862630B1 - Unité anti-débordement pour un dispositif microfluidique et dispositif microfluidique correspondant - Google Patents

Unité anti-débordement pour un dispositif microfluidique et dispositif microfluidique correspondant Download PDF

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Publication number
EP2862630B1
EP2862630B1 EP14186087.4A EP14186087A EP2862630B1 EP 2862630 B1 EP2862630 B1 EP 2862630B1 EP 14186087 A EP14186087 A EP 14186087A EP 2862630 B1 EP2862630 B1 EP 2862630B1
Authority
EP
European Patent Office
Prior art keywords
channel
resistance
pressure
protection unit
leakage protection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14186087.4A
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German (de)
English (en)
Other versions
EP2862630A1 (fr
Inventor
Thomas BRETTSCHNEIDER
Franz Laermer
Jochen Rupp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
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Publication of EP2862630A1 publication Critical patent/EP2862630A1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure

Definitions

  • the WO 02/41994 A2 discloses a test device for performing chemical testing of a fluid.
  • the testing device has a membrane which is arranged between an upper and a lower cavity and has a through opening.
  • At least a partial section of the resistance channel can have a liquid-absorbing material which is designed to close the resistance channel in a liquid-tight manner when a liquid is absorbed.
  • the liquid-absorbing material can be, for example, a fibrous material that increases in size when the liquid is absorbed in such a way that the resistance channel is closed in a liquid-tight manner. This can further increase the reliability of the leakage protection unit.
  • the liquid-absorbing material can be arranged between the cover recess and the pressure channel. This can prevent the fluid from leaking through the pressure channel if the cover recess overflows.
  • a sealing membrane can be formed between the resistance channel and the pressure channel in order to close the pressure channel in a liquid-tight manner.
  • a flat flexible element such as for example a plastic layer can be understood.
  • the sealing membrane can, for example, be gas-permeable but liquid-impermeable.
  • Fig. 1 shows a schematic representation of a leakage protection unit 100.
  • the leakage protection unit 100 has a cover element 105 and a base element 110.
  • a pressure channel 115 for applying pressure is formed in the cover element 105.
  • a base recess 120 is formed in the base element 110 as a fluid container 125.
  • the bottom recess 120 is arranged opposite the cover element 105.
  • a resistance channel 130 is formed between the cover element 105 and the base element 110 in order to fluidically couple the pressure channel 115 and the fluid container 125.
  • the resistance channel 130 represents a fluidic resistance which is such that a flow rate of a fluid located in the resistance channel 130 is reduced by a predetermined factor and leakage of the fluid via the pressure channel 115 is prevented.
  • the channel 130 can be recessed in either layer 105 or layer 110.
  • the pressure diversion channel 215 is designed to guide the pressure applied to the pressure channel 115 onto the film 200 in the area of the fluid container 125, so that the film 200 is deflected. Is it like in Fig. 2 by an overpressure, the film 200 is arched in the direction of the fluid container 125.
  • Another exemplary embodiment of the present invention provides that a material 305 is incorporated in front of the pneumatic interface 115 which does not impede the flow of gases. If the material 305 comes into contact with liquids, strong swelling leads to the closure of the cover recess channel 210.
  • Fig. 4 shows a schematic representation of a leakage protection unit 100 according to an embodiment of the present invention.
  • the leakage protection unit 100 shown is not formed in the cover element 105, but in the base element 110.
  • the leakage protection unit 100 comprises a sealing membrane 400, which is arranged in a region of the base element 110 between the pressure channel 115 and the cover recess channel 210.
  • the sealing membrane 400 is designed to fluidically separate the pressure channel 115 and the cover recess channel 210.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Claims (8)

  1. Unité anti-débordement (100) pour un dispositif microfluidique (600), l'unité anti-débordement (100) présentant les caractéristiques suivantes :
    un élément de couvercle (105) ;
    un élément de fond (110) dans lequel est réalisé au moins un évidement de fond (120) en tant que réservoir de fluide (125), l'évidement de fond (120) étant disposé à l'opposé de l'élément de couvercle (105) ;
    une feuille (200) qui est disposée entre l'élément de couvercle (105) et l'élément de fond (110) et qui ferme de manière étanche aux fluides le récipient de fluide (125) ;
    au moins un canal de pression (115) pour l'application d'une pression pneumatique commutant périodiquement entre une surpression et une dépression pour dévier et comprimer la feuille (200), le canal de pression (115) étant réalisé dans l'élément de fond (110) et/ou dans l'élément de couvercle (105) ; et
    au moins un canal de résistance (130) qui est réalisé entre l'élément de couvercle (105) et l'élément de fond (110) afin d'accoupler fluidiquement le canal de pression (115) et la feuille (200), le canal de résistance (130) représentant une résistance fluidique pour un fluide se trouvant dans le canal de résistance (130) ;
    caractérisée en ce que la feuille (200) présente le canal de résistance (130) et au moins un évidement de couvercle (205) en tant que composant du canal de résistance (130) est réalisé dans l'élément de couvercle (105) afin d'augmenter le un volume du canal de résistance (130), un volume de l'évidement de couvercle (205) étant de 1 µl à 10 ml et étant configuré de telle sorte que dans le cas d'une déchirure de la feuille (200), un front de liquide dans la phase d'aspiration n'avance pas jusqu'au canal de pression (115), et la feuille (200) présentant dans la région de l'évidement de couvercle (205) et/ou l'évidement de couvercle (205) présentant des éléments de résistance (500) pour former une structure servant de butée capillaire et/ou une couche hydrophobe afin d'augmenter la résistance fluidique, la résistance fluidique agissant en tant qu'étranglement pour des gaz.
  2. Unité anti-débordement (100) selon la revendication 1, caractérisée en ce que le canal de pression (115) est réalisé sous forme d'ouverture de passage dans l'élément de fond (110) et/ou l'élément de couvercle (105), l'évidement de fond (120) étant en outre disposé de manière décalée latéralement par rapport à l'ouverture de passage.
  3. Unité anti-débordement (100) selon l'une quelconque des revendications précédentes, caractérisée en ce que la résistance fluidique est prédéfinie par une forme de section transversale et/ou un diamètre et/ou une longueur du canal de résistance (130).
  4. Unité anti-débordement (100) selon l'une quelconque des revendications précédentes, caractérisée en ce qu'au moins un canal de dérivation de pression (215) avec une première ouverture de canal (220) et une deuxième ouverture de canal (225) est réalisé dans l'élément de couvercle (105), la première ouverture de canal (220) étant disposée à l'opposé du récipient de fluide (125) et la deuxième ouverture de canal (225) étant ou pouvant être accouplée fluidiquement au canal de résistance (130).
  5. Unité anti-débordement (100) selon l'une quelconque des revendications précédentes, caractérisée en ce qu'au moins une portion partielle du canal de résistance (130) présente un matériau (305) absorbant les liquides, lequel est réalisé pour fermer le canal de résistance (130) de manière étanche aux liquides en cas d'absorption d'un liquide.
  6. Unité anti-débordement (100) selon la revendication 5, caractérisée en ce que le matériau (305) absorbant les liquides est disposé entre l'évidement de couvercle (205) et le canal de pression (115).
  7. Unité anti-débordement (100) selon l'une quelconque des revendications précédentes, caractérisée en ce qu'une membrane de fermeture (400) est réalisée entre le canal de résistance (130) et le canal de pression (115) afin de fermer le canal de pression (115) de manière étanche aux liquides.
  8. Dispositif microfluidique (600) comprenant les caractéristiques suivantes :
    une unité anti-débordement (100) selon l'une quelconque des revendications précédentes ; et
    un moyen (605) pour appliquer la pression au canal de pression (115) de l'unité anti-débordement (100) .
EP14186087.4A 2013-10-10 2014-09-24 Unité anti-débordement pour un dispositif microfluidique et dispositif microfluidique correspondant Active EP2862630B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102013220445.0A DE102013220445B4 (de) 2013-10-10 2013-10-10 Auslaufschutzeinheit für eine mikrofluidische Vorrichtung, mikrofluidische Vorrichtung, Verfahren zum Betreiben einer solchen Auslaufschutzeinheit und Verfahren zum Herstellen einer solchen Auslaufschutzeinheit

Publications (2)

Publication Number Publication Date
EP2862630A1 EP2862630A1 (fr) 2015-04-22
EP2862630B1 true EP2862630B1 (fr) 2021-02-17

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EP (1) EP2862630B1 (fr)
DE (1) DE102013220445B4 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041994A2 (fr) * 2000-11-24 2002-05-30 Nextgen Sciences Ltd Analyses chimiques

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US20070014695A1 (en) * 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
US7780813B2 (en) * 2005-06-09 2010-08-24 Alcatel-Lucent Usa Inc. Electric field mediated chemical reactors
US20070095407A1 (en) * 2005-10-28 2007-05-03 Academia Sinica Electrically controlled addressable multi-dimensional microfluidic device and method
KR100790881B1 (ko) * 2006-07-06 2008-01-02 삼성전자주식회사 미세유체 반응칩 및 이의 제조방법
DE102009048378B3 (de) * 2009-10-06 2011-02-17 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mikrofluidische Struktur
DE102010028524A1 (de) * 2010-05-04 2011-11-10 Robert Bosch Gmbh Mikrofluidisches Bauteil, insbesondere peristaltische Mikropumpe, und Verfahren zu dessen Herstellung
JP6190822B2 (ja) * 2012-01-09 2017-08-30 マイクロニクス， インコーポレイテッド マイクロ流体リアクタシステム

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041994A2 (fr) * 2000-11-24 2002-05-30 Nextgen Sciences Ltd Analyses chimiques

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EP2862630A1 (fr) 2015-04-22
DE102013220445A1 (de) 2015-04-16
DE102013220445B4 (de) 2016-04-07

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