EP2858648A4 - Procédés et compositions pour inhiber pin1 - Google Patents
Procédés et compositions pour inhiber pin1Info
- Publication number
- EP2858648A4 EP2858648A4 EP13800857.8A EP13800857A EP2858648A4 EP 2858648 A4 EP2858648 A4 EP 2858648A4 EP 13800857 A EP13800857 A EP 13800857A EP 2858648 A4 EP2858648 A4 EP 2858648A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pin1
- inhibition
- compositions
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 101150037009 pin1 gene Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/4704—2-Quinolinones, e.g. carbostyril
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261656806P | 2012-06-07 | 2012-06-07 | |
PCT/US2013/044747 WO2013185055A1 (fr) | 2012-06-07 | 2013-06-07 | Procédés et compositions pour inhiber pin1 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2858648A1 EP2858648A1 (fr) | 2015-04-15 |
EP2858648A4 true EP2858648A4 (fr) | 2015-12-30 |
EP2858648B1 EP2858648B1 (fr) | 2018-08-22 |
Family
ID=49712688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13800857.8A Active EP2858648B1 (fr) | 2012-06-07 | 2013-06-07 | Procédés et compositions pour inhiber pin1 |
Country Status (6)
Country | Link |
---|---|
US (3) | US9730941B2 (fr) |
EP (1) | EP2858648B1 (fr) |
JP (2) | JP6449764B2 (fr) |
AU (1) | AU2013271378A1 (fr) |
CA (1) | CA2875798A1 (fr) |
WO (1) | WO2013185055A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
US10485780B2 (en) | 2011-03-14 | 2019-11-26 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the treatment of proliferative disorders |
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- 2013-06-07 US US14/406,401 patent/US9730941B2/en active Active
- 2013-06-07 WO PCT/US2013/044747 patent/WO2013185055A1/fr active Application Filing
- 2013-06-07 EP EP13800857.8A patent/EP2858648B1/fr active Active
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- 2013-06-07 CA CA2875798A patent/CA2875798A1/fr not_active Abandoned
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US9730941B2 (en) | 2017-08-15 |
US11129835B2 (en) | 2021-09-28 |
US10413548B2 (en) | 2019-09-17 |
JP6449764B2 (ja) | 2019-01-09 |
US20200093832A1 (en) | 2020-03-26 |
CA2875798A1 (fr) | 2013-12-12 |
EP2858648B1 (fr) | 2018-08-22 |
US20170304310A1 (en) | 2017-10-26 |
US20150133442A1 (en) | 2015-05-14 |
AU2013271378A1 (en) | 2014-12-18 |
JP2015518902A (ja) | 2015-07-06 |
EP2858648A1 (fr) | 2015-04-15 |
WO2013185055A1 (fr) | 2013-12-12 |
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