IT1398522B1 - Nuovi derivati furossanici idrosolubili aventi attivita' antitumorale. - Google Patents

Nuovi derivati furossanici idrosolubili aventi attivita' antitumorale.

Info

Publication number
IT1398522B1
IT1398522B1 ITMI2010A000287A ITMI20100287A IT1398522B1 IT 1398522 B1 IT1398522 B1 IT 1398522B1 IT MI2010A000287 A ITMI2010A000287 A IT MI2010A000287A IT MI20100287 A ITMI20100287 A IT MI20100287A IT 1398522 B1 IT1398522 B1 IT 1398522B1
Authority
IT
Italy
Prior art keywords
furossan
hydro
new
soluble derivatives
antitumoral activity
Prior art date
Application number
ITMI2010A000287A
Other languages
English (en)
Inventor
Alberto Gasco
Roberta Fruttero
Loretta Lazzarato
Marco Crosetti
Enzo Bronte
Antonella Viola
Original Assignee
Istituto Oncologico Veneto Irccs
Humanitas Mirasole Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Oncologico Veneto Irccs, Humanitas Mirasole Spa filed Critical Istituto Oncologico Veneto Irccs
Priority to ITMI2010A000287A priority Critical patent/IT1398522B1/it
Priority to PCT/IB2011/050743 priority patent/WO2011104671A1/en
Priority to PT117116665T priority patent/PT2539328E/pt
Priority to US13/522,026 priority patent/US8946271B2/en
Priority to DK11711666.5T priority patent/DK2539328T3/da
Priority to ES11711666.5T priority patent/ES2522841T3/es
Priority to EP11711666.5A priority patent/EP2539328B1/en
Publication of ITMI20100287A1 publication Critical patent/ITMI20100287A1/it
Application granted granted Critical
Publication of IT1398522B1 publication Critical patent/IT1398522B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ITMI2010A000287A 2010-02-23 2010-02-23 Nuovi derivati furossanici idrosolubili aventi attivita' antitumorale. IT1398522B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI2010A000287A IT1398522B1 (it) 2010-02-23 2010-02-23 Nuovi derivati furossanici idrosolubili aventi attivita' antitumorale.
PCT/IB2011/050743 WO2011104671A1 (en) 2010-02-23 2011-02-23 Novel water soluble furoxan derivatives having antitumor activity
PT117116665T PT2539328E (pt) 2010-02-23 2011-02-23 Derivados de furoxano solúveis em água com uma atividade antitumoral
US13/522,026 US8946271B2 (en) 2010-02-23 2011-02-23 Water soluble furoxan derivatives having antitumor activity
DK11711666.5T DK2539328T3 (da) 2010-02-23 2011-02-23 Vandopløselige furoxanderivater med antitumoraktivitet
ES11711666.5T ES2522841T3 (es) 2010-02-23 2011-02-23 Derivados de furoxano solubles en agua que tienen actividad antitumoral
EP11711666.5A EP2539328B1 (en) 2010-02-23 2011-02-23 Water soluble furoxan derivatives having antitumor activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A000287A IT1398522B1 (it) 2010-02-23 2010-02-23 Nuovi derivati furossanici idrosolubili aventi attivita' antitumorale.

Publications (2)

Publication Number Publication Date
ITMI20100287A1 ITMI20100287A1 (it) 2011-08-24
IT1398522B1 true IT1398522B1 (it) 2013-03-01

Family

ID=42676615

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A000287A IT1398522B1 (it) 2010-02-23 2010-02-23 Nuovi derivati furossanici idrosolubili aventi attivita' antitumorale.

Country Status (7)

Country Link
US (1) US8946271B2 (it)
EP (1) EP2539328B1 (it)
DK (1) DK2539328T3 (it)
ES (1) ES2522841T3 (it)
IT (1) IT1398522B1 (it)
PT (1) PT2539328E (it)
WO (1) WO2011104671A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013271378A1 (en) 2012-06-07 2014-12-18 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the inhibition of Pin1
US10351914B2 (en) 2014-07-17 2019-07-16 Beth Israel Deaconess Medical Center, Inc. Biomarkers for Pin1-associated disorders
WO2016145186A1 (en) 2015-03-12 2016-09-15 Beth Israel Deaconess Medical Center, Inc. Enhanced atra-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080293781A1 (en) * 2005-11-23 2008-11-27 Alberto Gasco Salicylic Acid Derivatives
WO2010081488A1 (en) * 2009-01-15 2010-07-22 Humanitas Mirasole S.P.A. Nitric oxide furoxan derivative compounds endowed with antitumoral activity

Also Published As

Publication number Publication date
ES2522841T3 (es) 2014-11-18
DK2539328T3 (da) 2014-11-03
PT2539328E (pt) 2014-11-05
US8946271B2 (en) 2015-02-03
ITMI20100287A1 (it) 2011-08-24
US20130035360A1 (en) 2013-02-07
EP2539328B1 (en) 2014-07-30
WO2011104671A1 (en) 2011-09-01
EP2539328A1 (en) 2013-01-02

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