EP2848307B1 - Dispositif de pipetage doté d'une structure d'accouplement pour une seringue pour pipette séparée et doté d'un corps de verrouillage déformable par le champ magnétique destiné à verrouiller et déverrouiller la seringue pour pipette sur la structure d'accouplement - Google Patents

Dispositif de pipetage doté d'une structure d'accouplement pour une seringue pour pipette séparée et doté d'un corps de verrouillage déformable par le champ magnétique destiné à verrouiller et déverrouiller la seringue pour pipette sur la structure d'accouplement Download PDF

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Publication number
EP2848307B1
EP2848307B1 EP14183427.5A EP14183427A EP2848307B1 EP 2848307 B1 EP2848307 B1 EP 2848307B1 EP 14183427 A EP14183427 A EP 14183427A EP 2848307 B1 EP2848307 B1 EP 2848307B1
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EP
European Patent Office
Prior art keywords
pipetting
yoke
locking
locking body
radially
Prior art date
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Active
Application number
EP14183427.5A
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German (de)
English (en)
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EP2848307A1 (fr
Inventor
Hanspeter Romer
Christoph Blattmann
Urs Lendenmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Bonaduz AG
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Hamilton Bonaduz AG
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Publication of EP2848307A1 publication Critical patent/EP2848307A1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips

Definitions

  • the present invention relates to a pipetting device for aspiration and dispensing of liquids, having a coupling formation for coupling a pipetting tip formed separately from the pipetting device thereon, the coupling formation being penetrated by a pipetting channel which extends through the coupling formation along a channel path, in particular a rectilinear channel axis , wherein the coupling formation cooperates with a deformable locking body which is disposed around the pipetting channel and radially between the coupling formation and the pipetting tip in the coupling state in which a pipetting tip is coupled to the coupling formation, the pipetting device further comprising a locking body actuating device is designed and activated to cause a deformation of the locking body, wherein the locking body depends on different Aktivieru Sgszupartyn the locking body actuating device relative to the channel track has different radial extension states.
  • a generic pipetting device is from the WO-A-0062933 known.
  • a portion of the coupling formation for coupling a pipetting tip is inserted axially into a counter-coupling formation of the pipetting tip.
  • the negative feedback formation surrounds an axial section of the coupling formation radially outward.
  • the O-ring can engage in the circumferential radial recess on the inner peripheral surface of the negative feedback portion of the pipette tip and thus lock the pipetting tip positively to the coupling formation.
  • the O-ring By relaxing the O-ring, it comes out of engagement with the recess on the inner peripheral surface of the negative feedback portion of the pipette tip, so that it can be stripped from the coupling formation.
  • the O-ring In the known pipetting device, the O-ring must be deformed as a locking body for the entire duration of coupling a pipette tip to the coupling formation, ie during the entire coupling period, the squeezing device must hold the O-ring deformed as the known locking body actuator and energized accordingly become.
  • DE 197 08 151 A1 shows a pipetting device for releasably attachable pipette tips with a moving device in which a magnet assembly, latch arrangement or spring arrangement releasably holds the decoupling elements in the connecting position.
  • the locking body can thus be changed in shape by changing a magnetic field acting on it, so that a pipetting tip can be held by means of the locking body on the coupling formation, depending on the strength and / or polarity of the magnetic field acting on the locking body be released from it for release from the coupling formation.
  • the material which can be changed in shape by changing a magnetic field comprises a polymer which can be brought into a desired shape in a particularly simple manner and which, in addition to its locking function, can also seal an annular gap existing in the coupling state between the coupling formation and the pipetting tip.
  • the locking body comprises a material which is form-changeable by magnetic field to a sufficient extent and has further materials next to it. For reasons of ease of manufacture and assembly, however, it is preferred to form the locking body from such a material.
  • the locking body comprises a material changeable by changing a magnetic field passing through it
  • the locking body actuating device is designed to change a magnetic field passing through the locking body. Since the squeezing device of the generic pipetting device of the prior art has an electromotive drive, which due to the system must have a magnetic field source and further device parts, such as gears and the like, the locking body actuating device of the present invention over the known from the prior art simplified , In the prior art, therefore, the locking body is mechanically deformed with an electromagnet in the electric motor as a power source, in the present invention, however, magnetic.
  • the material that can be changed in shape by magnetic field is a polymer filled with permanently magnetizable or / and permanently magnetized particles.
  • a polymer filled with permanently magnetizable or / and permanently magnetized particles owing to the polymer matrix it is possible on the one hand to ensure sufficient deformability and, due to the filling with permanently magnetizable or / and permanently magnetized particles, a sufficient shape change response of the material to an external magnetic field.
  • the permanent magnetizable and / or permanent magnetized particles are iron carbonyl particles, which are also available in small particle size in the micron range at a reasonable cost.
  • the polymer is polyvinyl acetate or silicone proved to be suitable for filling with permanent magnetizable and / or permanent magnetized particles.
  • the average particle diameters are small, for example less than 100 ⁇ m.
  • a polymer filled with permanently magnetizable or / and permanently magnetized particles can be the more homogeneous the smaller the average particle diameter is.
  • the permanent magnetizable and / or permanent magnetized particles have an average particle diameter in the range from 1 to 30 .mu.m, preferably 1 to 20 .mu.m, particularly preferably 1 to 10 microns.
  • the mean particle diameter can be determined by screening with appropriate mesh sizes.
  • the shape change response of the filled polymer may be too low on the change of a magnetic field acting from outside, so that the change in shape achievable by changing the magnetic field of the locking body is insufficient optionally hold a pipetting tip at the coupling formation and release it for release.
  • the particles may interfere with each other in mobility, so that a locking body formed of such a material may be too rigid to cause a sufficient strain response under the influence of a change of an external magnetic field.
  • the locking body may be formed in one piece or several pieces, so it may consist of a single or several separate components.
  • the locking body is a closed ring which, at least in the coupling state, preferably in each state, revolves around the channel path.
  • the locking body as a closed ring or at least a closed ring is a prerequisite that the locking body can not only keep a pipette tip locked to the coupling formation, but also can seal an existing between coupling formation and pipetting tip annular gap.
  • the locking body can then be sufficiently deformed with a particularly low expenditure of energy if it has a fixing portion designed for its attachment to a structure supporting it and a locking portion extending axially and / or radially from it.
  • the locking portion is formed by deformation relative to the fixing portion for locking a pipette tip to the coupling formation and for unlocking the same.
  • the fixing portion can be made relatively massive and with a large volume of material as compared with the locking portion, so that the fixing portion can be securely received on a structure supporting it.
  • the locking portion projecting from the fixing portion may be formed with thinner cross-sectional dimensions as compared with the fixing portion, so that the deformation thereof requires less causing force than the deformation of the locking portion more massive festiegeabitess.
  • the locking portion may be in the form of a lip, in particular a lip which completely surrounds the channel path.
  • the fixing portion may be formed to exercise substantially equal forces along the circumferential direction around the channel path as around the channel track circumferential ring.
  • the locking body for this purpose be rotationally symmetrical, in particular with the channel path as the rotational symmetry axis, be formed.
  • At least one outer surface exposed to the atmosphere, particularly preferably the outer surface, of the locking body has a closed polymer skin.
  • a condition in which a pipetting tip to be coupled is completely detached from the coupling formation and in which the locking body has a shape in which it is possible to attach the pipetting tip to the coupling formation and to strip it from the latter is decisive for the assessment of an exposure to the atmosphere is. This means that the locking body protrudes in this state radially less far from the structure carrying it before in the coupling state.
  • the locking body actuating device preferably comprises a magnet, said magnetic field acting on or passing through the locking body. This is preferably rotationally symmetrical with respect to the channel path to always be able to generate a substantially rotationally symmetrical magnetic field and thus a substantially rotationally symmetrical force along a circumferential direction around the channel path as the axis of rotational symmetry.
  • the magnet is for changing a locking body passing through, d. H. formed on this acting, magnetic field to realize different activation states of the locking body actuator.
  • the training for changing the magnetic field for example, in a permanent magnet by its displaceability to the locking body out and away from it, so that said magnet may be a relative to the channel path, preferably along the same, displaceable magnet.
  • this realization of the lock body actuator is less preferred.
  • the pipetting device may further comprise a control device which cooperates with the locking body actuating device for changing the locking body passing through, ie acting on it, magnetic field and thus just to change the activation state of the locking body actuator.
  • the control device may be configured to change the current intensity of the current flowing through the electromagnet.
  • a simple, compact coupling formation which does not differ in its dimensions from the existing coupling formations of the prior art, can be obtained by providing a conductor coil of the electromagnet in the coupling formation surrounding the pipetting channel.
  • the pipetting channel is thus not disturbed by the conductor coil of the electromagnet.
  • the coupling formation which usually has at least one cylindrical and / or conical section, is excellently suited, due to its shape, to receive a conductor coil of an electromagnet.
  • a virtual winding axis of the conductor coil or / and a cylinder axis or cone axis of the cylindrical or / and conical section coincides with the channel track, in particular the channel axis.
  • the outgoing from the conductor coil of the electromagnet magnetic field can be guided and amplified that the conductor coil of the electromagnet - with respect to the channel path - at least one axial axial ends of a ferromagnetic yoke leg is axially opposite. This effect is even greater when the conductor coil axially opposite at each axial longitudinal ends of a ferromagnetic yoke leg so that the conductor coil is located axially between the two yoke legs.
  • yoke base can be used as a winding support of the conductor coil, which facilitates the mounting of the electromagnet and the yoke base on the pipetting device.
  • a radial end of the yoke base facing away from the conductor coil can form a wall radially delimiting the pipetting channel in the coupling formation.
  • the yoke base both serve as a winding carrier, such as with a coil wound radially outward on her, as well as define a yoke passing through the pipetting channel.
  • the yoke base and the yoke leg preferably the yoke base and both yoke legs, are integrally formed.
  • At least one yoke limb, preferably both yoke limbs, and / or the yoke base can be rotationally symmetrical in order to provide a magnetic field which is as rotationally symmetrical as possible.
  • the channel path is preferably the rotational symmetry axis.
  • a radial end face of a yoke leg pointing radially outwards extends over an axial extension area, the locking body extending in this axial extent area End face, but located radially outside of it.
  • the material of the locking body which is changeable by changing the magnetic field, adjoins the end face radially directly, particularly preferably without any air gaps.
  • the locking force achievable by the locking body can be increased by locking the locking body a plurality of partial locking bodies, each of which partial locking body in the axial extension region of another radial End surface of the plurality of radial end surfaces, but located radially outside thereof.
  • the locking body comprises as many part-locking body as radial end surfaces of axially spaced yoke legs are provided.
  • the magnetically deformable material of each partial locking body adjoins the end face radially directly, particularly preferably free of air gaps, in the axial extent of which the partial locking body is located.
  • each partial locking body is just that, only in the axial extension region exactly one radial end surface of a yoke leg. It should not be ruled out that the locking body or the partial locking body, axially has a smaller or larger extent than the respectively associated radially outwardly facing radial end surface of a yoke leg. However, preferably only one such end face is associated with a partial latch body, i. H. the radial extension region of the partial locking body overlaps or overlaps only with the radial extension region of an end surface of a yoke leg.
  • the yoke leg is formed radially shorter than the coupling formation in which the yoke leg is received.
  • a particularly effective deformation of the locking body in particular if this as described above with a fixing section and a protruding therefrom locking portion can be achieved, that a conductor coil of the electromagnet radially inward, opposite to both axial sides and radially outwardly a ferromagnetic yoke, wherein the ferromagnetic yoke in the electromagnet radially outside and / or axially opposite region having the yoke interrupting gap, in which the locking body is arranged.
  • the locking body can be accommodated in the gap in such a way that it closes the gap at a certain energizing state of the electromagnet, ie supplements the ferromagnetic yoke to a yoke completely surrounding the electromagnet orthogonal to its winding direction and does not bridge the gap interrupting the yoke to a predetermined other energizing state , that is not enough from one column end to the other column end of the yoke.
  • the locking body may be provided in the predetermined other BestromungsPark with an air gap to both the yoke gap bounding surfaces.
  • the locking body is provided free of air gap on one of the gap delimiting yoke portions and is provided in a predetermined BestromungsSh to form a gap at a distance from the other of the other gap limiting yoke portion ,
  • the enforcement of the locking body is secured with the prevailing in the yoke gap depending on BestromungsSullivan of the electromagnet magnetic field.
  • the locking body in a predetermined further BestromungsSh at both the yoke gap bounding yoke portions is free of air gap.
  • the coupling formation usually has an insertion end, which is the axial longitudinal end of the coupling formation, which, when a pipetting tip is coupled to the coupling formation in a plug-in direction, is inserted first into a counter coupling formation of the pipetting tip becomes. Accordingly, when the pipetting tip is released from the coupling formation, the insertion end of the coupling formation leaves the counter-coupling formation of the pipetting tip last.
  • the coupling formation may be formed such that an insertion end of the coupling formation closer portion of a yoke portion which is opposite to the electromagnet radially outwardly formed radially thicker than the insertion end remote from the yoke portion.
  • the radially thicker yoke portion thus forms a larger diameter portion, behind which the locking body can be radially deformed back depending on the activation state of the locking body actuator to unlock the pipetting tip for release from the coupling formation.
  • the locking body may be deformed radially beyond the thicker yoke portion to lock the pipetting tip to the coupling formation.
  • the two regions of the yoke portion of different radial thickness may be separated by a gap. It may be the gap already described above.
  • the locking body is arranged in the gap.
  • an outer surface portion of the insertion end of the coupling formation further lying radially thinner yoke portion is formed as a contact surface portion for temporarily abutment of a portion of the locking body.
  • the region of the locking body reaching into the abutment surface section in a temporary abutment is the abovementioned locking section protruding from the securing section. The temporary application of a region of the locking body on the abutment surface portion takes place in dependence on the activation states of the locking body actuating device, in particular of the energization states of the electromagnet.
  • the lock body in the de-energized state of the electromagnet on the form which it assumes or assumes in the coupling state.
  • the locking body can be provided on an outer surface area of the radially thicker yoke portion independently of the activation state of the locking body actuating device. Since the radially thicker yoke section is formed on the region of a yoke section closer to the insertion end, the yoke gap on the side of the radially thicker yoke section is generally delimited by a free strin surface pointing in the axial direction, which is a particularly advantageous possibility of the air gap-free arrangement of the locking body offers to her.
  • a desired shape that the lock body or a portion thereof occupies in a predetermined activation state of the lock body operating device may be modeled by a support body to which the lock body is supported to varying degrees depending on activation states of the lock body operation device.
  • a support by surface abutment of the locking body or a portion thereof on the support body is preferred because this reduces the force exerted in the support state of the support body on the locking body load area.
  • the support body is a support ring, which rotates closed around the channel path in the same way as the preferably designed as a closed ring locking body.
  • a support body preferably in the form of a support ring, is provided radially between the coupling formation and a portion of the locking body.
  • the radial dimension of the support body in particular of the support ring, can change in the axial direction to a desired to the designed for temporary abutment against the support body portion of the locking body during its abutment against the support body Shape up the shape.
  • the radial dimension of the support body with progression in the axial direction increases from an end of the support body which is closer to the insertion end of the coupling formation to a end which is farther toward this end.
  • the magnet may comprise as electromagnet a plurality of conductor coils, in particular exactly two conductor coils. These conductor coils can be provided at an axial distance from each other, wherein the locking body can be arranged axially between two axially spaced apart conductor coils.
  • the locking body is preferably arranged between two directly axially adjacent conductor coils. In this case, the interlocking body can be surely penetrated by the magnetic field emanating from two or more conductor coils, which increases the strain work achievable on the interlocking body, so that the same interlocking body deforms more, and in particular changes its radial dimension more in response to the said magnetic field than if only a conductor coil would be present.
  • the locking body is provided on the coupling formation, preferably in a radial groove of the same.
  • the radial groove preferably circumferentially revolves around the channel path to provide an annular latch body receiving space. Since the locking body on the coupling formation is generally intended to frictionally engage the coupling formation in the coupling state in the coupling state of a pipetting tip, the radial groove is preferably formed on a radially outer jacket surface of the coupling formation.
  • the locking body in addition to the frictional force always acting between it and the pipetting tip in the event of a contact with the pipetting tip, the locking body can also bring about a positive engagement with the pipetting tip.
  • the locking body is provided on the pipette tip.
  • the pipetting device may comprise a pipetting tip, with which the locking body is firmly connected. Since, in the coupling state, at least one axial section of the coupling formation is surrounded by a negative feedback formation of the pipetting tip radially outward, the arrangement of the locking element on the negative feedback formation of the pipetting tip is preferred.
  • the locking body is preferably arranged on an inner surface of the negative feedback formation facing radially inward in the coupling state towards the coupling formation.
  • the penetration of the locking body with a magnetic field is used synonymous with an action of the magnetic field on the locking body.
  • said pipetting channel usually extends from the coupling formation into the pipetting device.
  • the portion of the pipetting channel located in the coupling formation should be of interest.
  • the coupling formation which is usually a has cylindrical or / and frusto-conical shape, preferably has the characteristic in their rectilinear shape as the channel axis channel path as a cylinder or cone axis.
  • Fig. 1a a first embodiment of a pipetting device according to the invention in the relevant section of the coupling engagement of a coupling formation of the pipetting device is shown with a negative feedback formation of a pipette tip.
  • FIG Fig. 1a The first embodiment of the pipetting device according to the invention is shown in FIG Fig. 1a generally designated 10.
  • the pipetting device 10 comprises at its coupling-side longitudinal end a coupling formation 12, which is penetrated by a pipetting channel 14.
  • the pipetting channel 14 generally extends along a channel path 16 through the coupling formation 12. This can basically have any, even curved course, but is preferably made for obvious reasons simple production and assembly as a rectilinear channel axis 16.
  • the channel axis or channel path should in principle define an axial direction and orthogonal starting from it, a radial direction for the description of the present application.
  • a circumferential direction is referred to in the present application, this refers to a circumferential direction around the channel axis.
  • the free axial longitudinal end 12a of the coupling formation 12, which is in the in Fig. 1a is shown plugged into a pipetting tip 18 is referred to in the present application as "insertion end”.
  • the axially opposite longitudinal end 12b is referred to as “device side Longitudinal end ".
  • the pipetting channel 14 continues axially beyond the device-side longitudinal end 12b of the coupling formation 12, for example into a cylinder 20 of the pipetting device 10.
  • a pressure change device 22 is connected in a manner not of further interest here. This may be a piston-cylinder arrangement in the cylinder 20 or a rotating pump.
  • the pressure change device 22 can be controlled via a control device 24.
  • the pressure of a working fluid in the pipetting channel 14 can be increased or decreased with respect to the ambient pressure, whereby aspiration or dispensing of liquid into or out of the pipette tip 18 can take place in a manner known per se.
  • a negative feedback formation 26 is shown, which in the in Fig. 1a Coupling state shown surrounding an axial portion of the coupling formation 12 radially outward.
  • the coupling formation 12 may have, in the region of its device-side longitudinal end 12b, a radial projection 12c against which the coupling-side longitudinal end 18a of the pipette tip 18 abuts in the coupling state in order to define the axial position of the pipetting tip 18 relative to the coupling formation 12.
  • the coupling formation 12 has an immersion section 12d, which is immersed axially in the coupling state in the pipetting tip 18 and is surrounded by the negative feedback formation 26 of the pipetting tip 18 radially outward.
  • the immersion section 12d extends axially from the contact surface of the radial projection 12c facing the pipette tip 18 to the insertion end 12a.
  • the immersion portion has a cylindrical or / and conical lateral surface, for example a cylindrical or steep-conical lateral surface portion 12d1 and a flat conical Lateral surface portion 12d2, which also serves as an insertion aid cone for inserting the insertion end 12a into the receiving space of the pipetting tip 18 surrounded by the negative feedback formation 26.
  • the cylindrical or steep-conical lateral surface portion 12d1 lies flat in the coupling state to an inner surface 18b of the counter-coupling formation 26 of the pipette tip 18 which points in the coupling state to the channel path 16.
  • a steep-conical formation of the lateral surface portion 12d1 of the coupling formation 12 and a corresponding negative-conical configuration of the inner wall 18b of the pipette tip 18 are preferred because this conical coupling and counter-coupling formation facilitates detachment of the pipette tip 18 from the coupling formation 12 in the axial direction.
  • a magnet 28 is accommodated, which in the example shown has two guide coils 28a and 28b arranged axially spaced from one another.
  • the conductor coils which may also be more than two conductor coils, can be surrounded on their sides by a securing on three sides, ie radially inward and on both axial sides of the material of the coupling formation 12. Radially outside, the conductor coils 28a and 28b can be exposed, thus forming part of the lateral surface portion 12d1.
  • the conductor coils 28a and 28b each extend around the channel track 16, the winding plane of which runs approximately orthogonally to the channel track or channel axis 16.
  • the conductor coils 28a and 28b are connected to the control device 24 via a power supply line, so that the conductor coils 28a and 28b can be energized by control with the control device 24.
  • the energization state of the conductor coils 28a and 28b is consequently variable by the control device 24.
  • the magnetic field emanating from the conductor coils 28a and 28b is in the case of a corresponding current supply changeable and even switched off by switching off an energization of the conductor coils 28a and 28b.
  • a preferably annularly formed locking body 30 is arranged. This is preferably received in a circumferentially around the channel track 16 circumferential radial groove 32 in the coupling formation.
  • Locking body 30 is formed from a polymer filled with iron carbonyl particles which is filled with the iron carbonyl particles having a fill level of about 70% by weight of iron carbonyl particles and 30% by weight of polymer mass (when viewed in the cured state) by the conductor coils 28a and 28b outgoing magnetic field is changeable form.
  • the locking body is designed according to an advantageous development of the present invention such that it locks the pipetting tip on the coupling formation without the influence of an external magnetic field, be it by positive locking and / or by frictional engagement, and that it is deformed under the influence of an external magnetic field such in that it releases the pipette tip for release from the coupling formation.
  • the magnet 28 thus constitutes a locking body actuating device in the sense of the present application.
  • the locking body 30 is in Fig. 1a in its shape unaffected by an external magnetic field.
  • the conductor coils 28a and 28b are thus not energized and they do not emit a magnetic field from them.
  • a radially outer portion 30a of the locking body 30 engage in a circumferential annular groove 34 in the inner surface 18b, so that the pipetting tip 18 is positively held by the locking body 30 to the coupling formation 12.
  • Fig. 1a the provided in the pipette tip 18 annular groove 34 is shown with V-shaped cross-sectional profile in positive engagement with the locking body 30.
  • the circumferential annular groove 34 of the pipette tip 18 may have a contour in which only the flank of the groove 34 located closer to the longitudinal end 18a in the in Fig. 1a illustrated manner is inclined while the axially opposite, the in Fig. 1a Not shown pipetting nearer edge oriented orthogonal to the channel path 16 and / or axially so far away from the beveled edge that the locking body 30 does not come into contact with this.
  • the radially outer portion 30a of the locking body 30 can come into contact contact exclusively with the inclined surface of the annular groove 34, so that in addition to the positive engagement, the pipette tip 18 can be biased by the locking body 30 against the radial projection 12c of the coupling formation 12, which is a unique axial position the pipette tip 18 is ensured relative to the coupling formation 12 and thus relative to the pipetting device 10.
  • flank of the annular groove 34 closer to the longitudinal end 18a can also be curved convexly or concavely or can be polygonal in cross-section, as long as only the contact with the locking body 30 causes an axial force to the radial projection 12c of the coupling formation 12.
  • Fig. 1b in which the cylinder 20, the pressure change device 22 and the control device 24 are not shown, is the coupling formation 12 of Fig. 1a shown with attached pipette tip 18, now the magnet 28, so the two conductor coils 28a and 28b, are energized and the magnetic field emanating from them acts on the locking body 30, so this enforced.
  • the pipetting device 10 For reasons of a safe release of the pipette tip 18 of the coupling formation 12, the pipetting device 10, however, a known per se and in the Fig. 1a and 1b Scraper device not shown for axially stripping the pipette tip 18 of the coupling formation 12 have.
  • the locking body 30 takes back in Fig. 1a shown position and shape.
  • different activation states of the magnet can also be achieved by reversing the same or / and by changing the current of the current flowing through it, but due to the associated higher cost (the magnet must then also in the operating state the Fig. 1a energized) is less preferred.
  • FIG. 2a and 2 B A second embodiment of the present invention is shown, which will be described below only insofar as it differs from the first embodiment described above.
  • Fig. 2a and 2 B Same and functionally identical components and component sections as in the first embodiment of Fig. 1a and 1b are in the Fig. 2a and 2 B denoted by the same reference numerals but increased by the number 100. If the Fig. 2a and 2 B are not expressly described, is to explain their explicit reference to the description of Fig. 1a and 1b directed.
  • the second embodiment of the Fig. 2a and 2 B has an electromagnet 128 with only a single conductor coil, which as in Fig. 1a shown with one in the Fig. 2a and 2 B not shown in detail is coupled energy transfer moderately.
  • the electromagnet 128 is surrounded at its two axial sides and radially inwardly by a ferromagnetic yoke 140.
  • the yoke 140 is preferably formed integrally from ferromagnetic material and comprises the yoke legs 140a and 140b and the yoke legs 140a and 140b axially connecting yoke base 140c.
  • the yoke 140 is preferably rotationally symmetrical with respect to the channel axis 116 as an axis of symmetry and simultaneously serves as a winding body for the conductor coil of the electromagnet 128.
  • a radially inner wall of the Yoke 140b forms a wall of pipetting channel 114. However, this need not be so. Instead, the pipetting channel 114 may be completely defined by material of the coupling device 112 which can axially penetrate the yoke 140.
  • the electromagnet 128 is surrounded radially on the outside by a ferromagnetic yoke ring 140d, so that the electromagnet 128 is surrounded on all sides by ferromagnetic yoke material.
  • the yoke 140 has between the yoke ring 140d and each of the two yoke legs 140a and 140b about the channel axis 116 encircling yoke gaps 132 1 and 132 2 , in which the locking body is arranged as a partial locking body 130 1 and 130 2 .
  • the insertion latching end 112a of the coupling formation 112 closer partial locking body 130 1 is located in the insertion end 112a closer yoke gap 132 1 .
  • the spigot 112 a further preferred partial locking body is located 1302 in the spigot 112a also located further yoke gap 132. 2
  • each partial locking body 130 1 and 1302 preferably closes air gap free to a radially outwardly facing radial end surface 140a1 or 140a2 of the respective yoke gap 132 1 and 132 2 radially inwardly limiting yoke leg 140a for the best possible coupling to the magnetic field generated by the electromagnet 128 or 140b.
  • energized state of the electromagnet 128 are the part-locking body 130 1 and 130 2 with respect to the state of Fig. 2a radially compressed and axially expanded.
  • the yoke gaps 132 1 and 132 2 are preferably completely or at least largely filled by the respective associated partial locking bodies 130 1 and 130 2 .
  • the partial locking bodies 130 1 and 130 2 radially withdrawn behind the outer diameter of the immersion portion 112 d of the coupling formation 112, so that the pipette tip 118 is unlocked for release from the coupling formation 112 and can be axially stripped off this or even can fall off axially.
  • FIG. 3a and 3b A third embodiment of the present invention is shown. This embodiment is described below only insofar as it differs from the first two, to the description of which otherwise expressly referred.
  • the third embodiment like the first, has only one locking body 230. This is arranged in a yoke gap 232 of the yoke 240. The yoke gap 232 again runs around the channel axis 216.
  • the yoke 240 is formed in two parts as in the second embodiment, wherein the separation of the different yoke components is different than in the second embodiment.
  • the radially inner yoke base 240c and the yoke leg 240b further away from the insertion end 212a form a common yoke component.
  • the yoke leg 240a closer to the insertion end 212a and a yoke portion 240d1 surrounding the electromagnet 228 radially outside form an integral further yoke component.
  • another yoke portion 240d2 surrounding the electromagnet 228 radially outwardly may be formed.
  • the parting plane between the yoke sections or yoke legs can also be different than in the Fig. 3a and 3b shown. For example, there may be a separation gap between each yoke leg and a yoke portion adjacent thereto, such as the yoke base.
  • the radially outer yoke portion 240d1 closer to the insertion end 212a is formed radially thicker than the radially outer yoke portion 240d2 farther from the insertion end 212a, preferably with the yoke portion 240d1 forming the largest diameter of the coupling formation 212 such that the negative coupling portion 226 of the pipetting tip 218 in the in-dash the Fig. 3a and 3b shown coupling state preferably in contact only with the lateral surface 212d1 of the yoke portion 240d1 stands.
  • the locking portion 230 has in the third embodiment, a fixing portion 231, with which it is preferably arranged on an axially facing end face 241 of the radially thicker, the insertion end 212a closer yoke portion 240d1 free of air gap.
  • Fig. 3a an activation state of the electromagnet 228 is shown, in which this is preferably energized.
  • the locking body 230 is with its locking portion 233 in form-locking engagement with the annular groove 234 on the inner wall 218 b of the negative feedback portion 226 of the pipette tip 218th
  • the locking body 230 is dimensioned for reasons of ease of deformability so that it is arranged in the yoke gap 232 that at least in the in Fig. 3a shown de-energized activation state of the electromagnet 228 is a gap 242 between the locking body 230 and the axial direction of the insertion end 212a facing end face of the radially thinner yoke portion 240d2.
  • activation state of energization of the electromagnet 228 is the locking portion 233, which was previously in positive engagement with the annular groove 234 of the pipette tip 218, on the radially outer lateral surface portion 244 of the yoke 240d2.
  • the locking body 230 more precisely locking portion 233, is completely retracted from the annular groove 234, so that the pipetting tip 218, as in FIG Fig. 3b is shown, is axially strippable from the coupling formation 212 or even gravity driven from this can fall off axially.
  • FIG. 4a and 4b A fourth embodiment of the present invention is shown, which will be described below only insofar as it differs from the preceding embodiments, the description of which is otherwise also referred to the explanation of the fourth embodiment.
  • first, second and third embodiments are in the fourth embodiment with provided with the same reference numerals, but increased by the number 300, 200 and 100, respectively.
  • the fourth embodiment is essentially a modification of the third embodiment.
  • the fourth embodiment substantially corresponds to the third embodiment, wherein the yoke 340 is shown in one piece, for example as a forged part.
  • the lock body 330 has a different shape than the lock body 230 of the third embodiment. Again, this has a fixing portion 331, which is preferably free of air gaps connected to an axially facing away from the insertion end 312a end face of the radially thicker yoke portion 340d1. From this fixing portion 331, the locking portion 333 protrudes.
  • a state of the pipetting device 310 is shown with the energized activation state of the electromagnet 328, while in Fig. 4b an energization state of energizing the electromagnet 328 is shown.
  • the essential difference between the fourth embodiment and the third embodiment presented before is a support body in the form of a circumferential about the Pipettierkanalachse 316 support ring 346, which is on a portion of the locking body 330 in abutment.
  • the surface of the support ring 346 contacting the latch body 330 may be fixedly connected to the latch body 330, such as by gluing.
  • the support ring may be made of non-magnetizable, permanently magnetisable or even permanently magnetized material.
  • it since it has only shape modeling function, it can also be inexpensively formed from advantageously non-magnetizable plastic.
  • the support ring has a radial thickness increasing away from the insertion end 312a.
  • the support ring 346 is designed in such a way that it projects radially increasingly from the pipetting channel axis 316 with increasing distance from the insertion end 312a.
  • the locking portion 333 of the locking body 330 is attracted to the radially outer surface 344 of the yoke portion 340d2, so that the locking portion 333 is completely deformed out of the circumferential annular groove 334 of the pipetting tip 318 and the pipetting tip 318 for axially stripping off or falling off the coupling formation 312 is enabled.
  • activation state of energization of the electromagnet 328 surrounds the locking body 330 partially the support ring 346 in the axial and radial directions.
  • the lock body 330 bridges the yoke gap 332 in which it is disposed completely, that is, in the fourth embodiment. H. the locking body 230 or 330 then extends from the yoke gap 232 or 332 bounding yoke portion 240d1 and 340d1 to the other yoke gap 232 and 332 delimiting yoke portion 240d2 and 340d2.
  • a fifth embodiment is shown in which the locking body is provided on the pipetting tip and fixedly connected thereto.
  • the fifth embodiment will be described below only insofar as it differs from the preceding embodiments 1 to 4, whose description is otherwise expressly referenced. Same and functionally identical components and component sections as in the embodiments 1 to 4 are provided in the fifth embodiment with the same reference numerals, but increased by the number 400, 300, 200 and 100, respectively.
  • the fifth embodiment has, like the second embodiment, two partial locking bodies 430 1 and 430 2 . These are essentially identical.
  • Each of the sub-locking bodies 430 1 and 4302 has a fixing portion 431 1 and 431 2 fixedly connected to the pipetting tip 418, from which a locking portion 433 1 and 433 2 projects.
  • the locking portions 433 1 and 433 2 radially inward and in the axial direction of the insertion end 412a away from the fixing portion 431 1 and 431 2 from.
  • the electromagnet 428 surrounds the pipetting tip 418 coupled to the coupling formation 412 radially outward. However, this does not have to be the case.
  • the electromagnet 428 may also be provided in the section of the coupling formation 412 projecting into the pipette tip 418, as is the case in the previously described embodiments 1 to 4.
  • Fig. 5a the pipetting tip 418 is held by friction engagement of the respective locking sections 433 1 and 4332 with the lateral surface of the part of the coupling formation 412 protruding into the pipette tip 418 on the pipetting device exclusively by frictional engagement.
  • the locking sections 433 1 and 433 2 may also alternatively or additionally engage in circumferential radial grooves on the portion of the coupling formation 412 projecting into the pipette tip 418.
  • Fig. 5b an activation state of a current supply of the electromagnet 428 is shown. Due to the magnetic field emanating from the electromagnet 428, the locking portions 433 1 and 433 2 in the radial direction are deformed away from the protruding into the pipette tip 418 portion of the coupling formation 412, so that the in Fig. 5a recognizable frictional lock is eliminated.
  • the pipetting tip 418 is thus unlocked and can be stripped in the axial direction of the coupling formation 412 or can fall from this axially due to gravity.
  • the pipetting tip 418 may be lined with a ferromagnetic shell 450.
  • the locking body is preferably at least in its exposed to the atmosphere and possibly applied to the pipette tip outer surface area formed by an uninterrupted polymer skin so that it can lock not only the pipette tip on the coupling formation, but also one between the pipette tip and the coupling formation can seal existing annular gap.
  • the portions of the locking body which are exposed to the atmosphere and are optionally exposed to the portion of the coupling formation projecting into the pipetting tip are preferably formed by a continuous polymer skin.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Quick-Acting Or Multi-Walled Pipe Joints (AREA)
  • Electromagnets (AREA)

Claims (26)

  1. Dispositif de pipetage pour l'aspiration et la dispensation de liquides, avec une structure d'accouplement (12 ; 112 ; 212 ; 312 ; 412) pour l'accouplement d'une pointe de pipetage (18 ; 118 ; 218 ; 318 ; 418) formée séparément du dispositif de pipetage, un canal de pipetage (14 ; 114 ; 214 ; 314 ; 414) passant à travers la structure d'accouplement (12 ; 112 ; 212 ; 312 ; 412), le canal s'étendant à travers la structure d'accouplement (12 ; 112 ; 212 ; 312 ; 412) le long d'une voie de canal (16 ; 116 ; 216 ; 316 ; 416), où un corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) déformable coopère avec la structure d'accouplement qui dans l'état d'accouplement où une pointe de pipetage (18 ; 118 ; 218 ; 318 ; 418) est accouplée à la structure d'accouplement (12 ; 112 ; 212 ; 312 ; 412) est arrangée entourant le canal de pipetage (14 ; 114 ; 214 ; 314 ; 414) et radialement entre la structure d'accouplement (12 ; 112 ; 212 ; 312 ; 412) et la pointe de pipetage (18 ; 118 ; 218 ; 318 ; 418), le dispositif de pipetage comprenant en outre un dispositif d'actuation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428) adapté et activable pour entraîner une déformation du corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430), le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) ayant des états d'extension radiale différents en fonction de différents états d'activation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428) par rapport à la voie de canal (16 ; 116 ; 216 ; 316 ; 416),
    caractérisé en ce que le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) comprend un matériau dont la forme peut être modifiée en modifiant un champ magnétique s'étendant à travers le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) et en ce que le dispositif d'actuation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428) est adapté pour modifier un champ magnétique s'étendant à travers le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430), où le matériau dont la forme peut être modifiée par le champ magnétique est un polymère rempli de particules magnétisés ou/et magnétisables de manière permanente.
  2. Dispositif de pipetage selon la revendication 1,
    caractérisé en ce que le matériau dont la forme peut être modifiée par le champ magnétique est un polymère rempli de particules fer-carbonyle magnétisés ou/et magnétisables de manière permanente, en particulier de l'APV ou de la silicone.
  3. Dispositif de pipetage selon la revendication 1 ou 2,
    caractérisé en ce que les particules magnétisés ou/et magnétisables de manière permanente ont un diamètre de particule moyen dans la gamme comprise entre 1 et 30 µm, de préférence 1 à 20 µm, de manière particulièrement préférée 1 à 10 µm.
  4. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce que le polymère rempli de particules fer-carbonyle magnétisés ou/et magnétisables de manière permanente comprend dans l'état durci et opérationnel 80 à 60% en poids de particules magnétisés ou/et magnétisables de manière permanente et 20 à 40% en poids de masse polymère.
  5. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce que le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) comprend un anneau fermé, et est en particulier un anneau fermé.
  6. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce que le corps de verrouillage (230 ; 330 ; 430) comprend une section de fixation (231 ; 331 ; 431) pour sa fixation à une structure qui le supporte et une section de verrouillage (233 ; 333 ; 433) en saillie axiale ou/et radiale de celle-ci, en particulier en forme de lèvre, qui est adaptée par déformation par rapport à la section de fixation (231 ; 331 ; 431) pour le verrouillage d'une pointe de pipetage (218 ; 318 ; 418) à la structure d'accouplement (212 ; 312 ; 412) et pour le déverrouillage de celle-ci.
  7. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce qu'au moins une surface externe du corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) exposée à l'atmosphère comprend une peau en polymère fermée.
  8. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce que le dispositif d'actuation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428) comprend un aimant (28 ; 128 ; 228 ; 328 ; 428), de préférence un aimant (28 ; 128 ; 228 ; 328 ; 428) à symétrie de rotation par rapport à la voie de canal (16 ; 116 ; 216 ; 316 ; 416) adapté pour modifier un champ magnétique s'étendant à travers le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) pour réaliser des états d'activation différents du dispositif d'actuation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428), le dispositif de pipetage comprenant en outre un dispositif de commande (24) qui coopère avec le dispositif d'actuation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428) pour modifier le champ magnétique s'étendant à travers le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430) et pour modifier ainsi l'état d'activation du dispositif d'actuation du corps de verrouillage (28 ; 128 ; 228 ; 328 ; 428).
  9. Dispositif de pipetage selon la revendication 8,
    caractérisé en ce que l'aimant (28 ; 128 ; 228 ; 328 ; 428) est un électroaimant (28 ; 128 ; 228 ; 328 ; 428) et en ce que le dispositif de commande (24) est adapté pour modifier l'intensité électrique du courant passant à travers l'électro-aimant (28 ; 128 ; 228 ; 328 ; 428).
  10. Dispositif de pipetage selon la revendication 9,
    caractérisé en ce qu'une bobine conductrice de l'électro-aimant (28 ; 128 ; 228 ; 328 ; 428) dans la structure d'accouplement (12 ; 112 ; 212 ; 312 ; 412) est prévue en entourant le canal de pipetage (14 ; 114 ; 214 ; 314 ; 414).
  11. Dispositif de pipetage selon la revendication 9 ou 10,
    caractérisé en ce qu'une branche de joug ferromagnétique (140a, 140b ;
    240a, 240b ; 340a, 340b) est axialement opposée à la bobine conductrice de l'électro-aimant (28 ; 128 ; 228 ; 328 ; 428) - par rapport à la voie de canal (16 ; 116 ; 216 ; 316 ; 416) - à au moins une de ses extrémités longitudinales axiales, que de préférence une joug ferromagnétique (140a, 140b ; 240a, 240b ; 340a, 340b) respective est axialement opposée à ses deux extrémités longitudinales axiales de sorte que la bobine conductrice est située axialement entre les deux jougs ferromagnétique (140a, 140b ; 240a, 240b ; 340a, 340b).
  12. Dispositif de pipetage selon une des revendications 9 à 11,
    caractérisé en ce qu'une base de joug (140c ; 240c ; 340c) est radialement opposée dans le sens radial - par rapport à la voie de canal (16 ; 116 ; 216 ; 316 ; 416) - à une bobine conductrice de l'électro-aimant (28 ; 128 ; 228 ; 328 ; 428), de préférence au côté radialement plus proche de la voie de canal (16 ; 116 ; 216 ; 316 ; 416), où de manière particulièrement préférée la base de joug (140c ; 240c ; 340c) est un support d'enroulement de la bobine conductrice.
  13. Dispositif de pipetage selon la revendications 11 et 12,
    caractérisé en ce que la base de joug (140c ; 240c ; 340c) et la branche de joug (140a, 140b ; 240a, 240b ; 340a, 340b), de préférence la base de joug (140c ; 240c ; 340c) et les deux branches de joug (140a, 140b ; 240a, 240b ; 340a, 340b) sont adaptées en une seule pièce.
  14. Dispositif de pipetage selon une des revendications 11 à 13,
    caractérisé en ce qu'une face d'extrémité radiale (140a1, 140b1) orientée radialement vers l'extérieur, d'une branche de joug (140a, 140b) s'étend sur une région d'extension axiale, où le corps de verrouillage (130) est situé dans cette région d'extension axiale de la face d'extrémité radiale (140a1, 140b1), mais radialement à l'extérieur de celle-ci, en particulier radialement directement adjacent à la face d'extrémité radiale (140a1, 140b1 ), où de préférence une pluralité de branches de joug (140a, 140b), en particulier deux branches de joug (140a, 140b), sont prévues avec une distance axiale mutuelle, dont chacune comprend une face d'extrémité radiale (140a1, 140b1) orientée radialement vers l'extérieur qui s'étend sur une région d'extension axiale, où le corps de verrouillage (130) comprend une pluralité de corps de verrouillage partiels (1301, 1302), en particulier deux corps de verrouillage partiels (1301, 1302) dont chaque corps de verrouillage partiel (1301, 1302) est situé dans la région d'extension axiale d'une autre face d'extrémité radiale (140a1, 140b1) de la pluralité de faces d'extrémité radiales (140a1, 140b1), mais radialement à l'extérieur de celle-ci.
  15. Dispositif de pipetage selon une des revendications 11 à 14,
    caractérisé en ce que la branche de joug (140a, 140b ; 240a, 240b ; 340a, 340b), ou dans le cas de plusieurs branches de joug (140a, 140b ; 240a, 240b ; 340a, 340b) au moins une branche de joug (140a, 140b ; 240a, 240b ; 340a, 340b), de préférence toutes les branches de joug (140a, 140b ; 240a, 240b ; 340a, 340b), est/sont radialement plus courtes que la structure d'accouplement (112 ; 212 ; 312 ; 412) dans laquelle ladite ou lesdites branches de joug (140a, 140b ; 240a, 240b ; 340a, 340b) est/sont reçues.
  16. Dispositif de pipetage selon une des revendications 9 à 15,
    caractérisé en ce qu'une joug ferromagnétique (140; 240 ; 340) est opposée à une bobine conductrice de l'électro-aimant (128 ; 228 ; 328) radialement à l'intérieur, aux deux côtés axiaux et radialement à l'extérieur, où la joug ferromagnétique (140; 240 ; 340) comprend dans une région radialement à l'extérieur de ou/et axialement opposée à l'électro-aimant (128 ; 228 ; 328) une fente (132 ; 232 ; 332) interrompant la joug (140; 240 ; 340), dans laquelle le corps de verrouillage (130 ; 230 ; 330) est arrangé.
  17. Dispositif de pipetage selon la revendication 16,
    caractérisé en ce que le corps de verrouillage (130 ; 230 ; 330) est arrangé dans la fente (132 ; 232 ; 332) interrompant la joug (140; 240 ; 340) de telle sorte qu'il est, dans un état d'activation prédéterminé du dispositif d'actuation du corps de verrouillage (128 ; 228 ; 328), en particulier dans un état de passage de courant prédéterminé de l'électro-aimant (28 ; 128 ; 228 ; 328 ; 428), prévu en formant un écart (242 ; 342) avec une distance à au moins une des sections de joug (140a, 140b, 140d ; 240d1, 240d2 ; 340d1, 340d2) délimitant la fente (132 ; 232 ; 332).
  18. Dispositif de pipetage selon la revendication 16 ou 17,
    caractérisé en ce qu'une région (240d1, 340d1) d'une section de joug (240d ; 340d) plus proche d'une extrémité d'insertion (212a ; 312a) de la structure d'accouplement (212 ; 312) qui est radialement à l'extérieur opposée à l'électro-aimant (228 ; 328), est radialement plus épaisse qu'une région (240d2, 340d2) de la section de joug (240d ; 340d) plus loin de l'extrémité d'insertion (212a ; 312a), où de préférence les deux régions (240d1, 240d2 ; 340d1, 340d2) de la section de joug (240d ; 340d) sont séparées par la fente (232 ; 332).
  19. Dispositif de pipetage selon la revendication 18,
    caractérisé en ce que les deux régions (240d1, 240d2 ; 340d1, 340d2) de la section de joug (240d ; 340d) d'épaisseur radiale différente sont séparées par la fente (232 ; 332), une section de surface externe (244 ; 344) de la section de joug (240d2, 340d2) plus éloignée de l'extrémité d'insertion (212a ; 312a) de la structure d'accouplement (212 ; 312) et radialement moins épaisse étant adaptée en tant que section de surface d'appui (244 ; 344) pour un appui temporaire d'une région du corps de verrouillage (230 ; 330) à celle-ci, où l'appui temporaire est réalisé en fonction des états d'activation du dispositif d'actuation de corps de verrouillage (228 ; 328).
  20. Dispositif de pipetage selon une des revendications 18 ou 19,
    caractérisé en ce que le corps de verrouillage (230 ; 330) est prévu à une région de surface extérieure (241 ; 341) de la section de joug radialement plus épaisse (240d1 ; 340d1) indépendamment de l'état d'activation du dispositif d'actuation de corps de verrouillage (228 ; 328), de préférence à une surface frontale (241 ; 341) libre de celle-ci, orientée dans une direction axiale.
  21. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce qu'un anneau de support (346) est prévu radialement entre la structure d'accouplement (312) et une section du corps de verrouillage (330), auquel le corps de verrouillage (330) est supporté en fonction d'états d'activation du dispositif d'actuation de corps de verrouillage (328), de préférence supporté en appui.
  22. Dispositif de pipetage selon la revendication 21,
    caractérisé en ce que la dimension radiale de l'anneau de support (346) change dans la direction axiale, de préférence avec la progression dans la direction axiale d'une extrémité plus proche de l'extrémité d'insertion (312a) de la structure d'accouplement (312) vers une extrémité plus loin de celle-ci.
  23. Dispositif de pipetage selon une des revendications 9 à 22,
    caractérisé en ce que l'aimant (28) comprend une pluralité de bobines conductrices (28a, 28b), en particulier deux bobines conductrices (28a, 28b) prévues avec une distance mutuelle axiale, le corps de verrouillage (30) étant arrangé axialement entre deux bobines conductrices (28a, 28b) prévues avec une distance mutuelle axiale, de préférence entre deux bobines conductrices (28a, 28b) axialement directement adjacentes.
  24. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce que le corps de verrouillage (30 ; 130) est prévu à la structure d'accouplement (12 ; 112), de préférence dans une rainure radiale (32 ; 132) de celle-ci.
  25. Dispositif de pipetage selon une des revendications précédentes,
    caractérisé en ce qu'il comprend une pointe de pipetage (18 ; 118 ; 218 ; 318 ; 418) et en ce que dans l'état d'accouplement le corps de verrouillage (30 ; 130 ; 230 ; 330 ; 430)
    a) vient en prise par derrière d'une projection radiale de la pointe de pipetage (18 ; 118 ; 218 ; 318 ; 418) projetant vers le canal de pipetage (14 ; 114 ; 214 ; 314 ; 414), ou
    b) s'étend dans une encoche radiale (34 ; 134a, 134b ; 234 ; 334) de la pointe de pipetage (18 ; 118 ; 218 ; 318 ; 418) qui s'éloigne radialement de l'axe de canal (16 ; 116 ; 216 ; 316 ; 416).
  26. Dispositif de pipetage selon une des revendications 1 à 24,
    caractérisé en ce qu'il comprend une pointe de pipetage (418) et en ce que le corps de verrouillage (430) est prévu à la pointe de pipetage (418) et est fixement connecté avec celle-ci, le corps de verrouillage (430) étant de préférence prévu à une contre-structure d'accouplement (426) entourant la structure d'accouplement (412) du dispositif de pipetage radialement à l'extérieur dans l'état d'accouplement de la pointe de pipetage (418).
EP14183427.5A 2013-09-09 2014-09-03 Dispositif de pipetage doté d'une structure d'accouplement pour une seringue pour pipette séparée et doté d'un corps de verrouillage déformable par le champ magnétique destiné à verrouiller et déverrouiller la seringue pour pipette sur la structure d'accouplement Active EP2848307B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201310218002 DE102013218002A1 (de) 2013-09-09 2013-09-09 Pipettiervorrichtung mit einer Kopplungsformation zur Ankopplung einer gesondert ausgebildeten Pipettierspitze und mit einem durch Magnetfeld formveränderbarem Verriegelungskörper zur Verriegelung und Entriegelung der Pipettierspitze an der Kopplungsformation

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EP2848307B1 true EP2848307B1 (fr) 2019-06-12

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EP14183427.5A Active EP2848307B1 (fr) 2013-09-09 2014-09-03 Dispositif de pipetage doté d'une structure d'accouplement pour une seringue pour pipette séparée et doté d'un corps de verrouillage déformable par le champ magnétique destiné à verrouiller et déverrouiller la seringue pour pipette sur la structure d'accouplement

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DE102015213005A1 (de) * 2015-07-10 2017-01-12 Hamilton Bonaduz Ag Pipettiervorrichtung mit ausstülpbarer Kopplungsformation zur Ankopplung einer Pipettierspitze sowie hierfür ausgebildete Pipettierspitze
DE102017220042A1 (de) * 2017-11-10 2019-05-16 Hamilton Bonaduz Ag Pipettiervorrichtung mit elektromagnetisch antreibbarem Verriegelungsaktuator zur Verriegelung von lösbar angekuppelten Pipettierspitzen
DE102017220892A1 (de) * 2017-11-22 2019-05-23 Hamilton Bonaduz Ag Pipettiervorrichtung mit doppelseitig nutzbarer Stator-Magnetanordnung als Teil eines linearmotorischen Antriebs einer Pipettiereinheit

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HU213215B (en) * 1995-07-06 1997-03-28 Gacs Magnetic polymer gels, process for producing thereof and use thereof
US5906795A (en) * 1996-04-08 1999-05-25 Sanyo Electric Co., Ltd. Pipetting apparatus
DE19708151C2 (de) * 1997-02-28 1999-05-27 Eppendorf Geraetebau Netheler Pipettiervorrichtung
DE19917375C2 (de) 1999-04-16 2001-09-27 Hamilton Bonaduz Ag Bonaduz Pipettiereinheit
US8337782B2 (en) * 2007-10-16 2012-12-25 Ivek Corporation Coupling system for use with fluid displacement apparatus
FI123648B (fi) * 2010-11-15 2013-08-30 Thermo Fisher Scientific Oy Monikanavapipetti
DE102011006581A1 (de) * 2011-03-31 2012-10-04 Hamilton Bonaduz Ag Zustandsüberwachung einer Pipettenspitze mit von innen angekoppelten piezoelektrischen Elementen

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